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https://www.readbyqxmd.com/read/27795625/a-prospective-audit-of-complications-in-100-consecutive-pediatric-percutaneous-renal-biopsies-done-under-real-time-ultrasound-guidance
#1
R Sinha, B Maji, B Sarkar, S Meur
Despite being a common procedure, percutaneous renal biopsy (PRB) carries the potential for complications. The British Association of Paediatric Nephrologist (BAPN) has published standards for pediatric PRB. As Indian data are scarce, we conducted a prospective audit of 100 consecutive pediatric renal biopsies (60% males) under real-time ultrasound guidance. Nephrotic syndrome was the most common indication for PRB (68%) with minimal change disease (30%) and focal segmental glomerulosclerosis (25%) being the most common histopathological lesions...
September 2016: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/27623226/-increased-lipoprotein-a-in-a-paediatric-patient-associated-with-nephrotic-syndrome
#2
Paloma Menéndez Valladares, Teresa Arrobas Velilla, José Antonio Bermúdez de la Vega, María Del Mar Romero Pérez, Fernando Fabiani Romero, Concepción González Rodríguez
A common complication in paediatric patients with nephrotic syndrome (NS) is hyperlipidaemia. About 20% of children do not respond to treatment with corticosteroids, presenting with a cortico-resistant NS (CRNS), which can progress to kidney failure. It has been observed that paediatric patients with CRNS have an elevated low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), and triglycerides levels, as well as elevated Lipoprotein-a [Lp (a)] levels. The case is presented of a 5 year old boy, diagnosed with CRNS, presenting with dyslipidaemia with increased LDL-c, Apo-B100, and Lp(a) levels...
September 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27566421/progress-in-pediatrics-in-2015-choices-in-allergy-endocrinology-gastroenterology-genetics-haematology-infectious-diseases-neonatology-nephrology-neurology-nutrition-oncology-and-pulmonology
#3
EDITORIAL
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Virginia Mirra, Sergio Bernasconi
This review focuses key advances in different pediatric fields that were published in Italian Journal of Pediatrics and in international journals in 2015. Weaning studies continue to show promise for preventing food allergy. New diagnostic tools are available for identifying the allergic origin of allergic-like symptoms. Advances have been reported in obesity, short stature and autoimmune endocrine disorders. New molecules are offered to reduce weight gain and insulin-resistance in obese children. Regional investigations may provide suggestions for preventing short stature...
August 27, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27540239/long-course-oral-corticosteroid-toxicity-in-children
#4
Fahad Aljebab, Imti Choonara, Sharon Conroy
BACKGROUND: Long courses of oral corticosteroids are commonly used in children in the management of conditions such as nephrotic syndrome, leukaemia, asthma and others. Various adverse drug reactions (ADRs) are known to occur with their use. This systematic review aimed to identify the most common and serious ADRs and to determine their relative risk levels. METHODS: A literature search of several databases; Embase, Medline, International Pharmaceutical Abstracts, CINAHL, the Cochrane Library and PubMed was performed to identify all studies where corticosteroids had been administered to paediatric patients ranging from 28 days to 18 years of age for at least 15 days of treatment...
September 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/27504551/comparison-of-efficacy-of-tacrolimus-versus-cyclosporine-in-childhood-steroid-resistant-nephrotic-syndrome
#5
Syed Sajid Hussain Shah, Farkhanda Hafeez
OBJECTIVE: To compare the efficacy of tacrolimus versus cyclosporine (Calcineurin Inhibitors) in the management of childhood steroid-resistant nephritic syndrome (SRNS). STUDY DESIGN: Quasi-experimental study. PLACE AND DURATION OF STUDY: Department of Paediatric Nephrology at The Children's Hospital and Institute of Child Health, Lahore, from August 2014 to September 2015. METHODOLOGY: Patients of either gender aged 1 - 12 years, with the diagnosis of mesangioproliferative glomerulonephritis (MesangioPGN), focal segmental glomerulosclerosis (FSGS) or minimal-change disease (MCD) were included...
July 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27504374/spectrum-of-renal-and-urinary-tract-diseases-in-kashmiri-children
#6
Mohd Ashraf, Virender Kumar, Rifat Ara Bano, Khursheed Ahmed Wani, Javed Ahmed, Kaisar Ahmed
INTRODUCTION: Definite paucity of data pertaining to spectrum of renal and urinary tract diseases in our state and in various parts of India forms the basis of this study. Available data has emphasized more on specific clinical syndromes and chronic renal diseases rather than over all spectrums of renal and urinary tract diseases, that too in adult population. AIM: The present study a retrospective analysis, forms one of the basic data of paediatric nephrology and urology related disorders in our state...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27134858/paraoxonase-activity-and-lipid-profile-in-paediatric-nephrotic-syndrome-a-cross-sectional-study
#7
Vijayetha P Patil, Anuradha B Patil, Vidya S Patil, Deepti G Ingleshwar
INTRODUCTION: Dyslipidaemia of Nephrotic Syndrome (NS) is known to be linked to oxidative reactions and atherosclerosis. Paraoxonase (PON1) has been implicated in the prevention of Low Density Lipoprotein (LDL) lipid peroxidation and also degrades biologically active oxidised lipids in lipoprotein. AIM: The present study was taken up to assess PON1 levels in paediatric nephrotic syndrome and also to see if any correlation exists between lipid parameters and PON1...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27121656/body-composition-estimation-using-skinfolds-in-children-with-and-without-health-conditions-affecting-growth-and-body-composition
#8
Danielle Wendel, David Weber, Mary B Leonard, Sheela N Magge, Andrea Kelly, Virginia A Stallings, Mary Pipan, Nicolas Stettler, Babette S Zemel
BACKGROUND: Body composition prediction equations using skinfolds are useful alternatives to advanced techniques, but their utility across diverse paediatric populations is unknown. AIM: To evaluate published and new prediction equations across diverse samples of children with health conditions affecting growth and body composition. SUBJECTS AND METHODS: Anthropometric and dual-energy X-ray absorptiometry (DXA) body composition measures were obtained in children with Down syndrome (n = 59), Crohn disease (n = 128), steroid-sensitive nephrotic syndrome (n = 67) and a healthy reference group (n = 835)...
April 27, 2016: Annals of Human Biology
https://www.readbyqxmd.com/read/27004322/tacrolimus-drug-level-and-response-to-treatment-in-idiopathic-childhood-steroid-resistant-nephrotic-syndrome
#9
Syed Sajid Hussain Shah, Farkhanda Hafeez, Naureen Akhtar
BACKGROUND: The management of Steroid Resistant Nephrotic Syndrome (SRNS) is an uphill task for paediatric nephrologists as immunosuppressive agents are the mainstay of treatment in these patients. Tacrolimus is used along with steroids. This study is conducted to see the relationship between the tacrolimus dose, drug level and response in the management of SRNS. METHODS: This quasi experimental study was conducted at The Children's Hospital Lahore over a period of one year...
October 2015: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/26862624/audit-of-blood-transfusion-practices-in-the-paediatric-medical-ward-of-a-tertiary-hospital-in-southeast-nigeria
#10
M D Ughasoro, A N Ikefuna, I J Emodi, S N Ibeziako, S O Nwose
OBJECTIVES: To determine the indications, practices and outcomes of transfusion on children. DESIGN: A descriptive retrospective study. SETTING: Paediatric wards of University of Nigeria Teaching Hospital, Enugu, Nigeria. SUBJECTS: Children one month to 18 years that received blood transfusion. MAIN OUTCOME MEASURES: Indications for the transfusion, haemoglobin rise, vital signs, duration of transfusion and adverse events...
January 2013: East African Medical Journal
https://www.readbyqxmd.com/read/26721026/histopathological-patterns-in-paediatric-idiopathic-steroid-resistant-nephrotic-syndrome
#11
Syed Sajid Hussain Shah, Naureen Akhtar, Faiza Sunbleen, Mohammad Fahim ur Rehman, Tausif Ahmed
BACKGROUND: Steroid-resistant nephrotic syndrome (SRNS) is a common problem but difficult to treat for pediatric nephrologists. Due to paucity of studies done in few centres in southern Pakistan regarding the histopathological aspects in paediatric patients with SRNS, this study was conducted to determine the histopathological spectrum in children with SRNS at our centre. METHODS: This descriptive study has been conducted at the Nephrology department, The Children's Hospital Lahore from February 2014 to January 2015...
July 2015: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/26613028/plasma-exchange-for-paediatric-kidney-disease-indications-and-outcomes-a-single-centre-experience
#12
Sudheer Kumar Reddy, Afsana Jahan, Swasti Chaturvedi, Indira Agarwal
BACKGROUND: Outcome data in paediatrics regarding the use of plasmapheresis for immunological kidney disease are scarce. OBJECTIVES: We aimed to evaluate the role of plasmapheresis in children presenting with severe renal impairment secondary to immunological kidney diseases. METHODS: A retrospective chart review of children admitted between January 2009 and August 2013 to the Paediatric Nephrology Unit, Christian Medical College, Vellore, India, and requiring plasma exchange was undertaken...
December 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26608393/renal-involvement-in-a-french-paediatric-cohort-of-patients-with-lysinuric-protein-intolerance
#13
C Nicolas, N Bednarek, V Vuiblet, O Boyer, A Brassier, P De Lonlay, L Galmiche, P Krug, V Baudouin, S Pichard, M Schiff, C Pietrement
Lysinuric protein intolerance (LPI) is a rare autosomal recessive metabolic disorder, caused by defective transport of cationic amino acids at the basolateral membrane of epithelial cells, typically in intestines and kidneys. The SLC7A7 gene, mutated in LPI patients, encodes the light subunit (y+LAT1) of a member of the heterodimeric amino acid transporter family.The diagnosis of LPI is difficult due to unspecific clinical features: protein intolerance, failure to thrive and vomiting after weaning. Later on, patients may present delayed growth osteoporosis, hepatosplenomegaly, muscle hypotonia and life-threatening complications such as alveolar proteinosis, haemophagocytic lymphohistiocytosis and macrophage activation syndrome...
2016: JIMD Reports
https://www.readbyqxmd.com/read/26556028/the-non-immunosuppressive-management-of-childhood-nephrotic-syndrome
#14
REVIEW
James McCaffrey, Rachel Lennon, Nicholas J A Webb
Idiopathic nephrotic syndrome (INS) is one of the most common renal diseases found in the paediatric population and is associated with significant complications, including infection and thrombosis. A high proportion of children enter sustained remission before adulthood, and therapy must therefore mitigate the childhood complications, while minimising the long-term risk to health. Here we address the main complications of INS and summarise the available evidence and guidance to aid the clinician in determining the appropriate treatment for children with INS under their care...
September 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26357562/posterior-reversible-encephalopathy-syndrome-in-two-omani-children-with-underlying-renal-diseases
#15
Mohamed A El-Naggari, Dana Al-Nabhani, Ibtisam El-Nour, Alaa El-Manzalawy, Anas-Alwogud A Abdelmogheth
Posterior reversible encephalopathy syndrome (PRES) is a neurological condition with a combination of clinical and radiological features. Clinical symptoms include headaches, confusion, seizures, disturbed vision or an altered level of consciousness. Classic magnetic resonance imaging (MRI) findings indicate subcortical and cortical oedema, affecting mainly the posterior cerebral region. We report two paediatric cases of PRES with underlying renal diseases presenting at the Sultan Qaboos University Hospital in Muscat, Oman, in April 2010 and August 2011...
August 2015: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/26289063/steroid-sensitive-nephrotic-syndrome-an-evidence-based-update-of-immunosuppressive-treatment-in-children
#16
REVIEW
Nicholas Larkins, Siah Kim, Jonathan Craig, Elisabeth Hodson
Nephrotic syndrome is one of the most common paediatric glomerular diseases, with an incidence of around two per 100,000 children per year. Corticosteroids are the mainstay of treatment, with 85%-90% of children going into remission with an 8-week course of treatment. Unfortunately, nephrotic syndrome follows a relapsing and remitting course in the majority, with 90% relapsing at least once. About half will progress to frequently relapsing nephrotic syndrome (FRNS) or steroid-dependent nephrotic syndrome (SDNS)...
April 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26248471/domiciliary-administration-of-intravenous-albumin-in-congenital-nephrotic-syndrome
#17
Ben Christopher Reynolds, Charles William Pickles, Heather Joan Lambert, Milos Ognjanovic, Jean Crosier, Sally Ann Johnson, Yincent Tse
BACKGROUND: Early management of congenital nephrotic syndrome invariably includes the frequent administration of intravenous human albumin solution. The safety and feasibility of intravenous administration of albumin in the patients' home setting has not previously been reported. CASE-DIAGNOSIS/TREATMENT: We report a series of seven paediatric patients whose parents were trained in the administration of albumin via a central venous catheter at home, with the aim of minimising hospital admission or attendances...
November 2015: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/26231174/a-retrospective-review-of-telehealth-services-for-children-referred-to-a-paediatric-nephrologist
#18
Peter Trnka, Megan M White, William D Renton, Steven J McTaggart, John R Burke, Anthony C Smith
BACKGROUND: Telemedicine has emerged as an alternative mode of health care delivery over the last decade. To date, there is very limited published information in the field of telehealth and paediatric nephrology. The aim of this study was to review our experience with paediatric telenephrology in Queensland, Australia. METHODS: A retrospective audit of paediatric nephrology telehealth consultations to determine the nature of the telehealth activity, reasons for referral to telehealth, and to compare costs and potential savings of the telehealth service...
August 1, 2015: BMC Nephrology
https://www.readbyqxmd.com/read/26194981/antibodies-to-m-type-phospholipase-a2-receptor-in-children-with-idiopathic-membranous-nephropathy
#19
Vinod Kumar, Raja Ramachandran, Ashwani Kumar, Ritambhra Nada, Deepti Suri, Anju Gupta, Harbir Singh Kohli, Krishan Lal Gupta, Vivekanand Jha
Idiopathic membranous nephropathy (IMN), the commonest cause of adult nephrotic syndrome (NS), accounts for only a minority of paediatric NS. Antibodies to m-type phospholipase A2 receptor (PLA2R) are seen in two-thirds of adult IMN cases. PLA2R staining in glomerular deposits is observed in 74% and 45% of adult and paediatric IMN cases, respectively. However, there are no reports of anti-PLA2R in paediatric IMN. We evaluated anti-PLA2R levels and PLA2R in gloemrular deposits in paediatric IMN seen at our center...
August 2015: Nephrology
https://www.readbyqxmd.com/read/25984092/novel-mutation-in-wilms-tumour-1-gene-associated-with-steroid-resistant-nephrotic-syndrome
#20
Olga Beltcheva, Anelia Boueva, Ekaterina Morgunova, Emilia Boiadjieva, Svetlana Marinova, Radka Kaneva, Vanio Mitev
We report the case of a paediatric patient with steroid-resistant nephrotic syndrome due to a novel dominant Wilms' tumour 1 mutation. The nucleotide change C1184A, identified in exon 9, results in amino acid substitution Ser395Tyr. Genotyping of parents and healthy controls indicated that this is a de novo mutation not present in healthy individuals. The affected amino acid is evolutionarily conserved and is located in a functionally important domain of the protein involved in DNA binding. Molecular modelling based on crystallography data indicated that the substitution would have a deleterious effect on the protein function...
February 2011: NDT Plus
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