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Diabetes and inflammation

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https://www.readbyqxmd.com/read/29166590/interleukin-33-activated-islet-resident-innate-lymphoid-cells-promote-insulin-secretion-through-myeloid-cell-retinoic-acid-production
#1
Elise Dalmas, Frank M Lehmann, Erez Dror, Stephan Wueest, Constanze Thienel, Marcela Borsigova, Marc Stawiski, Emmanuel Traunecker, Fabrizio C Lucchini, Dianne H Dapito, Sandra M Kallert, Bruno Guigas, Francois Pattou, Julie Kerr-Conte, Pierre Maechler, Jean-Philippe Girard, Daniel Konrad, Christian Wolfrum, Marianne Böni-Schnetzler, Daniela Finke, Marc Y Donath
Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retinoic acid (RA)-producing capacities in macrophages and dendritic cells via the secretion of IL-13 and colony-stimulating factor 2...
November 21, 2017: Immunity
https://www.readbyqxmd.com/read/29166392/intestinal-ralstonia-pickettii-augments-glucose-intolerance-in-obesity
#2
Shanthadevi D Udayappan, Petia Kovatcheva-Datchary, Guido J Bakker, Stefan R Havik, Hilde Herrema, Patrice D Cani, Kristien E Bouter, Clara Belzer, Julia J Witjes, Anne Vrieze, Noor de Sonnaville, Alice Chaplin, Daniel H van Raalte, Steven Aalvink, Geesje M Dallinga-Thie, Hans G H J Heilig, Göran Bergström, Suzan van der Meij, Bart A van Wagensveld, Joost B L Hoekstra, Frits Holleman, Erik S G Stroes, Albert K Groen, Fredrik Bäckhed, Willem M de Vos, Max Nieuwdorp
An altered intestinal microbiota composition has been implicated in the pathogenesis of metabolic disease including obesity and type 2 diabetes mellitus (T2DM). Low grade inflammation, potentially initiated by the intestinal microbiota, has been suggested to be a driving force in the development of insulin resistance in obesity. Here, we report that bacterial DNA is present in mesenteric adipose tissue of obese but otherwise healthy human subjects. Pyrosequencing of bacterial 16S rRNA genes revealed that DNA from the Gram-negative species Ralstonia was most prevalent...
2017: PloS One
https://www.readbyqxmd.com/read/29166372/placental-lipid-processing-in-response-to-a-maternal-high-fat-diet-and-diabetes-in-rats
#3
Eli J Louwagie, Tricia D Larsen, Angela L Wachal, Michelle L Baack
BACKGROUND: Diabetes and obesity during pregnancy impact the health of both mothers and developing babies. Prevention focuses on glycemic control, but increasing evidence implicates a role for lipids. Using a rat model, we showed that a maternal high-fat (HF) diet, increased perinatal morbidity and mortality, but lipid processing across the maternal-placental-fetal triad remained unstudied. We hypothesized that HF diet would disrupt placental lipid processing to exaggerate fuel-mediated consequences of diabetic pregnancy...
November 22, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29165404/benefits-of-nut-consumption-on-insulin-resistance-and-cardiovascular-risk-factors-multiple-potential-mechanisms-of-actions
#4
REVIEW
Yoona Kim, Jennifer B Keogh, Peter M Clifton
Epidemiological and clinical studies have indicated that nut consumption could be a healthy dietary strategy to prevent and treat type 2 diabetes (T2DM) and related cardiovascular disease (CVD). The objective of this review is to examine the potential mechanisms of action of nuts addressing effects on glycemic control, weight management, energy balance, appetite, gut microbiota modification, lipid metabolism, oxidative stress, inflammation, endothelial function and blood pressure with a focus on data from both animal and human studies...
November 22, 2017: Nutrients
https://www.readbyqxmd.com/read/29165098/effects-of-olive-oil-on-tnf-%C3%AE-and-il-6-in-humans-implication-in-obesity-and-frailty
#5
Nagendra Sastry Yarla, Angela Polito, Ilaria Peluso
BACKGROUND AND OBJECTIVE: Tumor necrosis factor-alpha (TNF)-α and interleukin (IL)-6 are important mediators of chronic low-grade systemic inflammation. The latter plays a central role in several obesity-related pathologies, such as diabetes, metabolic syndrome and cardiovascular diseases. Besides, these cytokines have been also implicated in geriatric and cancer-induced anorexia, cachexia, sarcopenia and frailty. Potential interventions for both obesity and frailty include dietary advice and nutraceuticals...
November 20, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29164155/new-insights-into-the-mechanisms-of-chinese-herbal-products-on-diabetes-a-focus-on-the-bacteria-mucosal-immunity-inflammation-diabetes-axis
#6
REVIEW
Zezheng Gao, Qingwei Li, Xuemin Wu, Xuemin Zhao, Linhua Zhao, Xiaolin Tong
Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29164153/sirt1-regulates-cognitive-performance-and-ability-of-learning-and-memory-in-diabetic-and-nondiabetic-models
#7
REVIEW
Yue Cao, Zi Yan, Tong Zhou, Guixia Wang
Type 2 diabetes mellitus is a complex age-related metabolic disease. Cognitive dysfunction and learning and memory deficits are main characteristics of age-related metabolic diseases in the central nervous system. The underlying mechanisms contributing to cognitive decline are complex, especially cognitive dysfunction associated with type 2 diabetes mellitus. SIRT1, as one of the modulators in insulin resistance, is indispensable for learning and memory. In the present study, deacetylation, oxidative stress, mitochondrial dysfunction, inflammation, microRNA, and tau phosphorylation are considered in the context of mechanism and significance of SIRT1 in learning and memory in diabetic and nondiabetic murine models...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29164116/potential-of-metformin-to-improve-cardiac-risk-in-postpartum-women-with-gestational-diabetes
#8
Oscar A Viteri, Mary Alice Sallman, Pauline M Berens, Pamela D Berens, Farah H Amro, Maria S Hutchinson, Susan M Ramin, Sean C Blackwell, Jerrie S Refuerzo, Judith A Smith
Objective: Pregnancy is associated with an increase in total cholesterol, high density lipoproteins (HDL), and low-density lipoproteins (LDL). Postpartum, HDL and LDL decrease over the first 12 weeks postpartum. Oxidized LDL (ox-LDL) is a marker of oxidative stress-related inflammation, which is associated with obesity and also with development of cardiovascular disease. Cardiovascular protection and weight loss are benefits from metformin, especially in women with diabetes. The objective of this study was to compare changes in lipid profiles and biomarkers for obesity during the initial 6 weeks postpartum between women with gestational diabetes mellitus (GDM) treated with metformin versus placebo...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29163354/diabetes-and-sepsis-risk-recurrence-and-ruination
#9
REVIEW
Lynn M Frydrych, Fatemeh Fattahi, Katherine He, Peter A Ward, Matthew J Delano
Sepsis develops when an infection surpasses local tissue containment. A series of dysregulated physiological responses are generated, leading to organ dysfunction and a 10% mortality risk. When patients with sepsis demonstrate elevated serum lactates and require vasopressor therapy to maintain adequate blood pressure in the absence of hypovolemia, they are in septic shock with an in-hospital mortality rate >40%. With improvements in intensive care treatment strategies, overall sepsis mortality has diminished to ~20% at 30 days; however, mortality continues to steadily climb after recovery from the acute event...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163027/mechanisms-of-osteoarthritic-pain-studies-in-humans-and-experimental-models
#10
REVIEW
Annett Eitner, Gunther O Hofmann, Hans-Georg Schaible
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However, the mechanisms of OA pain are poorly understood. This review addresses the mechanisms which are thought to be involved in OA pain, derived from studies on pain mechanisms in humans and in experimental models of OA. Three areas will be considered, namely local processes in the joint associated with OA pain, neuronal mechanisms involved in OA pain, and general factors which influence OA pain. Except the cartilage all structures of the joints are innervated by nociceptors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29162792/association-of-skin-autofluorescence-with-periodontal-inflammation-in-adults-with-type-1-diabetes
#11
Anna Duda-Sobczak, Jakub Lipski, Mateusz Tarnowski, Anna Surdacka, Dorota Zozulińska-Ziółkiewicz, Marzena Wyganowska-Świątkowska
No abstract text is available yet for this article.
October 31, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29162603/exogenous-insulin-infusion-can-decrease-atherosclerosis-in-diabetic-rodents-by-improving-lipids-inflammation-and-endothelial-function
#12
Kyoungmin Park, Qian Li, Net Daş Evcimen, Christian Rask-Madsen, Yasutaka Maeda, Ernesto Maddaloni, Hisashi Yokomizo, Takanori Shinjo, Ronald St-Louis, Jialin Fu, Daniel Gordin, Mogher Khamaisi, David Pober, Hillary Keenan, George L King
OBJECTIVE: The objective of this study is to evaluate whether exogenously induced hyperinsulinemia may increase the development of atherosclerosis. APPROACH AND RESULTS: Hyperinsulinemia, induced by exogenous insulin implantation in high-fat fed (60% fat HFD) apolipoprotein E-deficient mice (ApoE(-/-)) mice, exhibited insulin resistance, hyperglycemia, and hyperinsulinemia. Atherosclerosis was measured by the accumulation of fat, macrophage, and extracellular matrix in the aorta...
November 21, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29161661/chlorogenic-acid-prevents-diabetic-nephropathy-by-inhibiting-oxidative-stress-and-inflammation-through-modulation-of-the-nrf2-ho-1-and-nf-%C3%A4-b-pathways
#13
Liping Bao, Jushuang Li, Dongqing Zha, Lian Zhang, Ping Gao, Tao Yao, Xiaoyan Wu
Oxidative and inflammatory damage have been suggested to play important roles in the pathogenesis of diabetic nephropathy (DN). Chlorogenic acid (CGA) is one of the most abundant polyphenols and has known immunoprotective, antioxidant and anti-inflammatory properties. In the present study, animal experiments were designed to examine the protective effects of CGA in DN, and cellular experiments were designed to explore the underlying mechanisms. CGA significantly attenuated diabetic renal damage based on histological pathology and molecular biological methods...
November 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29161229/sex-and-dose-specific-effects-of-maternal-bisphenol-a-exposure-on-pancreatic-islets-of-first-and-second-generation-adult-mice-offspring
#14
Amita Bansal, Cetewayo Rashid, Frances Xin, Changhong Li, Erzsebet Polyak, Anna Duemler, Tom van der Meer, Martha Stefaniak, Sana Wajid, Nicolai Doliba, Marisa S Bartolomei, Rebecca A Simmons
BACKGROUND: Exposure to the environmental endocrine disruptor bisphenol A (BPA) is ubiquitous and associated with the increased risk of diabetes and obesity. However, the underlying mechanisms remain unknown. We recently demonstrated that perinatal BPA exposure is associated with higher body fat, impaired glucose tolerance, and reduced insulin secretion in first- (F1) and second-generation (F2) C57BL/6J male mice offspring. OBJECTIVE: We sought to determine the multigenerational effects of maternal bisphenol A exposure on mouse pancreatic islets...
September 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29160108/effects-of-hepato-preferential-basal-insulin-peglispro-on-nuclear-magnetic-resonance-biomarkers-lipoprotein-insulin-resistance-index-and-glyca-in-patients-with-diabetes
#15
Margery A Connelly, James D Otvos, Qianyi Zhang, Shuyu Zhang, Caryl J Antalis, Annette M Chang, Byron J Hoogwerf
AIM: To characterize the effects of hepato-preferential basal insulin peglispro (BIL) and insulin glargine on insulin resistance (lipoprotein insulin resistance index [LP-IR]) and inflammation (GlycA), and to explore the biological implications. METHODS: This substudy included 847 patients with Type 1 diabetes (T1D) or Type 2 diabetes (T2D) in four cohorts of the BIL development program. LP-IR and GlycA were measured before and after insulin treatment. Correlations between LP-IR, GlycA, clinical parameters and liver biomarkers were assessed...
November 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29160087/glyoxalase-1-modulation-in-obesity-and-diabetes
#16
Naila Rabbani, Paul J Thornalley
SIGNIFICANCE: Obesity and type 2 diabetes mellitus are increasing globally. There is also increasing associated complications, such as non-alcoholic fatty liver disease (NAFLD) and vascular complications of diabetes. There is currently no licensed treatment for NAFLD and no recent treatments for diabetic complications. New approaches are required, particularly addressing mechanism-based risk factors for health decline and disease progression. Recent advances: Dicarbonyl stress is the abnormal accumulation of reactive dicarbonyl metabolites such as methylglyoxal leading to cell and tissue dysfunction...
November 21, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29159964/blocking-antibodies-induced-by-allergen-specific-immunotherapy-ameliorate-allergic-airway-disease-in-a-human-mouse-chimeric-model
#17
Caterina Vizzardelli, Miriam Gindl, Simone Roos, Christian Möbs, Birgit Nagl, Felix Zimmann, Veronika Sexl, Lukas Kenner, Alina Neunkirchner, Gerhard J Zlabinger, Winfried F Pickl, Wolfgang Pfützner, Barbara Bohle
BACKGROUND: Allergen-specific immunotherapy (AIT) induces specific blocking antibodies (Ab) which are claimed to prevent IgE-mediated reactions to allergens. Additionally, AIT modulates cellular responses to allergens, e.g. by desensitizing effector cells, inducing regulatory T and B lymphocytes and immune deviation. It is still enigmatic which of these mechanisms mediate(s) clinical tolerance. We sought to address the role of AIT-induced blocking Ab separately from cellular responses in a chimeric human/mouse model of respiratory allergy...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29158465/tonicity-responsive-enhancer-binding-protein-mediates-hyperglycemia-induced-inflammation-and-vascular-and-renal-injury
#18
Soo Youn Choi, Sun Woo Lim, Shabnam Salimi, Eun Jin Yoo, Whaseon Lee-Kwon, Hwan Hee Lee, Jun Ho Lee, Braxton D Mitchell, Satoru Sanada, Afshin Parsa, Hyug Moo Kwon
Diabetic nephropathy (DN) has become the single leading cause of ESRD in developed nations. Bearing in mind the paucity of effective treatment for DN and progressive CKD, novel targets for treatment are sorely needed. We previously reported that increased activity of tonicity-responsive enhancer-binding protein (TonEBP) in monocytes was associated with early DN in humans. We now extend these findings by testing the hypotheses that TonEBP in macrophages promotes hyperglycemia-mediated proinflammatory activation and chronic renal inflammation leading to DN and CKD, and TonEBP genetic variability in humans is associated with inflammatory, renal, and vascular function-related phenotypes...
November 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29158420/superoxide-production-by-nadph-oxidase-intensifies-macrophage-antiviral-responses-during-diabetogenic-coxsackievirus-infection
#19
Ashley R Burg, Shaonli Das, Lindsey E Padgett, Zachary E Koenig, Hubert M Tse
Coxsackievirus B infections are suspected environmental triggers of type 1 diabetes (T1D) and macrophage antiviral responses may provide a link to virus-induced T1D. We previously demonstrated an important role for NADPH oxidase (NOX)-derived superoxide production during T1D pathogenesis, as NOX-deficient NOD mice (NOD.Ncf1(m1J) ) were protected against T1D due, in part, to impaired proinflammatory TLR signaling in NOD.Ncf1(m1J) macrophages. Therefore, we hypothesized that loss of NOX-derived superoxide would dampen diabetogenic antiviral macrophage responses and protect from virus-induced diabetes...
November 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29158134/the-inflammasome-pathway-is-amplified-and-perpetuated-in-an-autocrine-manner-through-connexin43-hemichannel-mediated-atp-release
#20
Odunayo O Mugisho, Colin R Green, Dan T Kho, Jie Zhang, E Scott Graham, Monica L Acosta, Ilva D Rupenthal
BACKGROUND: Connexin43 hemichannels have been implicated in many inflammatory diseases including diabetic retinopathy (DR). Particularly, hemichannel-mediated ATP release has been associated with inflammasome pathway activation. Using an in vitro cell culture model, we evaluated hemichannel roles in response to inflammatory cytokines under high glucose (HG) conditions and propose a mechanism by which a connexin43 hemichannel-mediated autocrine ATP feedback loop augments chronic inflammatory disease...
November 17, 2017: Biochimica et Biophysica Acta
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