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Lactate AND Pain

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https://www.readbyqxmd.com/read/28910416/lateralized-behaviour-as-indicator-of-affective-state-in-dairy-cows
#1
Sarah Kappel, Michael T Mendl, David C Barrett, Joanna C Murrell, Helen R Whay
In humans, there is evidence that sensory processing of novel or threatening stimuli is right hemisphere dominated, especially in people experiencing negative affective states. There is also evidence for similar lateralization in a number of non-human animal species. Here we investigate whether this is also the case in domestic cattle that may experience long-term negative states due to commonly occurring conditions such as lameness. Health and welfare implications associated with pain in lame cows are a major concern in dairy farming...
2017: PloS One
https://www.readbyqxmd.com/read/28899466/-clinical-features-and-etfdh-mutations-of-children-with-late-onset-glutaric-aciduria-type-ii-a-report-of-two-cases
#2
Yan-Yang Cheng, Yue Tang, Ao-Jie Liu, Li Wei, Lan Lin, Jing Zhang, Liang Zhi
OBJECTIVE: To investigate the clinical and genetic features of two families with late-onset glutaric aciduria type II caused by ETFDH mutations. METHODS: Target gene sequence capture and next generation sequencing were used for sequencing of suspected patients and their family members. The patients' clinical features were retrospectively analyzed and literature review was performed. RESULTS: The probands of the two families had a clinical onset at the ages of 10 years and 5...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28891830/comparison-of-postoperative-pain-and-residual-gas-between-restrictive-and-liberal-fluid-therapy-in-patients-undergoing-laparoscopic-cholecystectomy
#3
Lei Yao, Yulan Wang, Boxiang Du, Jie Song, Fuhai Ji
BACKGROUND: Different fluid regimens are used in the clinical management of perioperative fluid therapy, but there still is the argument about which fluid regimen is better for patients. This study was mainly designed to compare different fluid regimens on postoperative pain and residual gas in patients undergoing laparoscopic cholecystectomy. METHODS: A total of 100 patients were equally randomized to receive restrictive fluid infusion (n=50) with lactated Ringer (LR) solution 5 mL/kg/h or liberal fluid infusion (n=50), with 30 mL/kg/h lactated Ringer solution...
September 7, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28889225/effects-of-blood-flow-restriction-during-moderate-intensity-eccentric-knee-extensions
#4
Michael Behringer, Lars Heinke, Jannik Leyendecker, Joachim Mester
We investigated if blood flow restriction (BFR, cuff pressure 20 mmHG below individual occlusion pressure) increases metabolic stress, hormonal response, release of muscle damage markers, and muscle swelling induced by moderate-intensity eccentric contractions. In a randomized, matched-pair design, 20 male subjects (25.3 ± 3.3 years) performed four sets of unilateral eccentric knee extensions (75% 1RM) to volitional failure with (IG) or without (CG) femoral BFR. Despite significant differences of performed repetitions between IG (85...
September 9, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28879617/high-but-not-moderate-intensity-endurance-training-increases-pain-tolerance-a-randomised-trial
#5
Thomas J O'Leary, Johnny Collett, Ken Howells, Martyn G Morris
PURPOSE: To examine the effect of high-intensity interval training (HIIT) compared to volume-matched moderate-intensity continuous training (CONT) on muscle pain tolerance and high-intensity exercise tolerance. METHODS: Twenty healthy adults were randomly assigned (1:1) to either 6 weeks of HIIT [6-8 × 5 min at halfway between lactate threshold and maximal oxygen uptake (50%Δ)] or volume-matched CONT (~60-80 min at 90% lactate threshold) on a cycle ergometer...
September 6, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28843693/leukocyte-profile-gene-expression-acute-phase-response-and-metabolite-status-of-cows-with-sole-hemorrhages
#6
Keelin O'Driscoll, Matthew McCabe, Bernadette Earley
Sole hemorrhages result from disruption to normal claw horn formation and are caused by a variety of internal and external factors. Evidence suggests that they are painful, although they do not usually cause clinical lameness and are difficult to detect by observing cow gait. Little is known about how or whether sole hemorrhages affect the cow systemically. This study compared hematology profile, leukocyte gene expression, and physiological responses of cows with no/mild hemorrhages (category 1; n = 17), moderate hemorrhages (category 2; n = 18), and severe hemorrhages (category 3; n = 12)...
August 23, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28817412/effect-of-physical-methods-of-lymphatic-drainage-on-postexercise-recovery-of-mixed-martial-arts-athletes
#7
Aleksandra Zebrowska, Robert Trybulski, Robert Roczniok, Wieslaw Marcol
OBJECTIVE: Physical methods are reported to be important for accelerating skeletal muscle regeneration, decreasing muscle soreness, and shortening of the recovery time. The aim of the study was to assess the effect of the physical methods of lymphatic drainage (PMLD) such as manual lymphatic drainage (MLD), the Bodyflow (BF) therapy, and lymphatic drainage by deep oscillation (DO) on postexercise regeneration of the forearm muscles of mixed martial arts (MMA) athletes. DESIGN AND METHODS: Eighty MMA athletes aged 27...
August 16, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28804587/primary-hepatic-lymphoma-mimicking-cholangiocarcinoma
#8
Foroogh Forghani, Mohsen Masoodi, Maryam Kadivar
Primary hepatic lymphoma (PHL) presenting with obstructive jaundice is rare and can mimic a preoperative diagnosis of cholangiocarcinoma. We should consider PHL in patients with radiological hepatic disease with normal serum alpha-fetoprotein and carcinoembryonic antigen levels, and elevated lactate dehydrogenase. We present the case of a 67-year-old male with no significant medical history presented with abdominal pain, jaundice, fever, and abnormal liver function tests. Abdominal sonography and computed tomography scan suggested a diagnosis of obstructive jaundice and cholangitis due to cholangiocarcinoma (Klatskin tumor)...
July 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28800730/genotypes-of-hepatitis-a-virus-in-turkey-first-report-and-clinical-profile-of-children-infected-with-sub-genotypes-ia-and-iiia
#9
Huseyin Yilmaz, Asiye Karakullukcu, Nuri Turan, Utku Y Cizmecigil, Aysun Yilmaz, Ayse A Ozkul, Ozge Aydin, Alper Gunduz, Mahmut Mete, Fadile Y Zeyrek, Taner T Kirazoglu, Juergen A Richt, Bekir Kocazeybek
BACKGROUND: Hepatitis A virus (HAV) is a food and water-borne virus causing clinical (mainly hepatitis) and subclinical disease in humans. It is important to characterize circulating strains of HAV in order to prevent HAV infections using efficacious vaccines. The aim of this study was the detection and characterization of the circulating strains of HAV in Turkey by performing serology, RT-PCR, sequencing and phylogenetic analysis. METHODS: In this study, 355 HAV suspected cases were analysed by ELISA for the presence of antibodies to HAV...
August 11, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28790267/-a-case-of-recurrent-colorectal-cancer-with-bilateral-ovarian-metastases-that-were-reduced-with-regorafenib-therapy
#10
Shiro Nakae, Yuya Nogi, Jun Arima, Daiki Okamoto, Naoki Urakawa, Masataka Fujikawa, Hidetoshi Gon, Atsushi Takebe, Makoto Shinzeki, Kenichi Tanaka, Hideto Senzaki
A 63-year-old woman had recurrences of metastatic rectal cancer in the lung, peritoneum, and ovary. Regorafenib was administered at 160mg/day as third-line chemotherapy. The patient developed Grade(Gr)3 hand-foot syndrome(HFS) and Gr 2 rash, but the abdominal distension and pain were relieved by the 1st course. Analgesics could be reduced and regorafenib was administrated at reduced dosage. The patient received keishi-bukuryo-gan(EK-25)and sai-rei-tou(TJ-114) for HFS. At the beginning of therapy, ovarian metastases were not reduced and showed poor contrast enhancement on CT...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28752645/effect-of-pumping-pressure-on-onset-of-lactation-after-caesarean-section-a-randomized-controlled-study
#11
Feng Zhang, Yahui Yang, Ting Bai, Lele Sun, Mingzhu Sun, Xueling Shi, Meng Zhu, Meijuan Ge, Haiou Xia
Caesarean section is associated with weaker newborn suction pressure. This nonblinded, randomized trial explored the effect of suction pressures generating by a breast pump on mothers' onset of lactation and milk supply after caesarean section. A high pressure group (-150 mmHg), a low pressure group (-100 mmHg), and a control group (none) were generated under computer random assignment with concealed allocation in 2 tertiary hospitals. The breast pumping began within 2 hr after caesarean operation (6 times a day and 30 min per time) until onset of lactation...
July 27, 2017: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/28751057/the-role-of-surgical-management-in-primary-small-bowel-lymphoma-a-single-center-experience
#12
Y-W Hong, I-M Kuo, Y-Y Liu, T-S Yeh
INTRODUCTION: Information on primary small intestinal lymphoma is more limited than for gastric lymphoma because most of the previous studies did not focus on the former. Few prognostic indicators in primary intestinal lymphoma have been reliably established because of limited patient numbers and variations in criteria for patient selection. In this study, we retrospectively reviewed the clinical and pathological characteristics of small intestinal lymphoma cases from our hospital, to determine prognostic factors and to clarify the effect of surgical resection on prognosis...
July 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28747414/muscular-sarcocystosis-an-index-case-in-a-native-malaysian
#13
Nurashikin Mohammad, Alwi Muhd Besari, Pradeep Kumar Nair, Wan Syamimee Wan Ghazali
A previously healthy 20-year-old man presented with prolonged intermittent low grade fever and cough for 6months. He had bilateral calf pain and lower limb weakness 2days prior to admission. Physical examination revealed multiple enlarged lymph nodes with hepatomegaly. There was bilateral calf tenderness with evidence of proximal myopathy. Full blood picture showed lymphocytosis with reactive lymphocytes and eosinophilia. Creatine kinase and lactate dehydrogenase were markedly elevated. Over 2 weeks of admission, patient was treated symptomatically until the muscle biopsy of right calf revealed eosinophilic myositis with muscular sarcocystosis...
July 26, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28740418/comparison-of-patient-controlled-intravenous-analgesia-with-sufentanil-versus-tramadol-in-post-cesarean-section-pain-management-and-lactation-after-general-anesthesia-a-prospective-randomized-double-blind-controlled-study
#14
Xiaohui Chi, Man Li, Wei Mei, Mingfeng Liao
INTRODUCTION: Acute pain is a common complication following cesarean section under general anesthesia. Post-cesarean section pain management is important for both the mother and the newborn. This study compared the effects of patient-controlled intravenous analgesia (PCIA) using sufentanil or tramadol on postoperative pain control and initiation time of lactation in patients who underwent cesarean section under general anesthesia. METHODS: Primiparas (n=146) scheduled for cesarean section under general anesthesia were randomized to receive PCIA with sufentanil or tramadol...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28736511/effects-of-methylsulfonylmethane-msm-on-exercise-induced-oxidative-stress-muscle-damage-and-pain-following-a-half-marathon-a-double-blind-randomized-placebo-controlled-trial
#15
Eric D Withee, Kimberly M Tippens, Regina Dehen, Deanne Tibbitts, Douglas Hanes, Heather Zwickey
BACKGROUND: Oxidative stress and muscle damage occur during exhaustive bouts of exercise, and many runners report pain and soreness as major influences on changes or breaks in training regimens, creating a barrier to training persistence. Methylsulfonylmethane (MSM) is a sulfur-based nutritional supplement that is purported to have pain and inflammation-reducing effects. To investigate the effects of MSM in attenuating damage associated with physical exertion, this randomized, double-blind, placebo-controlled study evaluated the effects of MSM supplementation on exercise-induced pain, oxidative stress and muscle damage...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28733534/low-dose-of-dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-cesarean-surgery-provides-better-intraoperative-somato-visceral-sensory-block-characteristcs-and-postoperative-analgesia
#16
Yong-Hong Bi, Xiao-Guang Cui, Rui-Qin Zhang, Chun-Yu Song, Yan-Zhuo Zhang
OBJECT: In this study, we aimed to investigate the beneficial effects of dexmedetomidine on somato-visceral sensory block characteristcs, postoperative analgesia and stress response of intrathecal bupivacaine administration in women undergoing cesarean section, and to find out which dose is better. METHODS: Sixty parturients with the American Society of Anesthesiologists (ASA) physical status I or II were anesthetized with intrathecal bupivacaine(10mg) alone or in combination with dexmedetomidine (3 μg and 5 μg) to undergo cesarean section...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28704470/mammary-candidiasis-a-medical-condition-without-scientific-evidence
#17
Esther Jiménez, Rebeca Arroyo, Nivia Cárdenas, María Marín, Pilar Serrano, Leonides Fernández, Juan M Rodríguez
Many physicians, midwives and lactation consultants still believe that yeasts (particularly Candida spp.) play an important role as an agent of nipple and breast pain despite the absolute absence of scientific proofs to establish such association. In this context, the objective of this study was to investigate the microorganisms involved in sore nipples and/or painful "shooting" breastfeeding by using a variety of microscopy techniques, as well as culture-dependent and-independent identification methods. Initially, 60 women (30 diagnosed as suffering "mammary candidiasis" and 30 with no painful breastfeeding) were recruited to elucidate the role of their pumps on the milk microbial profiles...
2017: PloS One
https://www.readbyqxmd.com/read/28674366/m-protein-negative-myeloma-mimicking-lumbar-disc-herniation
#18
Yusuke Hirota, Shingo Suzuki, Yota Katsuyama, Tohru Iseki, Masatomi Ikusaka
A 60-year-old man was referred to us with high levels of aspartate aminotransferase and lactate dehydrogenase (LDH). He did not complain of any symptoms; however, he had been diagnosed with lumbar disc herniation, even though his back pain improved only to half of its previous level with pregabalin. Thus, we asked about the red flag of back pain and confirmed that he had involuntary body weight loss, which led us to diagnose truly non-secretory multiple myeloma, a variant of multiple myeloma that is associated with M-protein negativity and a normal serum free light chain level...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28673715/muscle-pain-induced-by-static-contraction-in-rats-is-modulated-by-peripheral-inflammatory-mechanisms
#19
Diogo Francisco da Silva Dos Santos, Bruna de Melo Aquino, Carolina Ocanha Jorge, Graciana de Azambuja, Jalile Garcia Schiavuzzo, Suzy Krimon, Juliana Dos Santos Neves, Carlos Amilcar Parada, Maria Claudia Gonçalves Oliveira-Fusaro
Muscle pain is an important health issue and frequently related to static force exertion. The aim of this study is to evaluate whether peripheral inflammatory mechanisms are involved with static contraction-induced muscle pain in rats. To this end, we developed a model of muscle pain induced by static contraction performed by applying electrical pulses through electrodes inserted into muscle. We also evaluated the involvement of neutrophil migration, bradykinin, sympathetic amines and prostanoids. A single session of sustained static contraction of gastrocnemius muscle induced acute mechanical muscle hyperalgesia without affecting locomotor activity and with no evidence of structural damage in muscle tissue...
June 30, 2017: Neuroscience
https://www.readbyqxmd.com/read/28671869/prognostic-value-of-neutrophil-to-lymphocyte-ratio-and-risk-factors-for-mortality-in-patients-with-stanford-type-a-aortic-dissection
#20
Kursad Oz, Taner Iyigun, Zeynep Karaman, Ömer Çelik, Ertan Akbay, Okan Akınc, Okan Akınc, Korhan Erkanli
BACKGROUND: Neutrophil to lymphocyte ratio (NLR) is a prognostic predictor in a wide range of cardiovascular disease. Acute aortic dissection (AD) is an uncommon but fatal cardiovascular disease. In this study, we investigated both prognostic factors in patients with AD and whether NLR can be a predictor for mortality. Methods: We analyzed retrospectively the data of 57 patients with AD who had undergone emergent surgery in our hospital and included 128 consecutive patients with chest pain admitted to the emergency room as a control group...
June 30, 2017: Heart Surgery Forum
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