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https://www.readbyqxmd.com/read/28422927/the-relationship-between-specialty-certification-of-individual-nurses-and-outcomes-developing-a-standardized-taxonomy-for-research
#1
Simon Kitto, Rachel Grant, Kathy Chappell, Vicki Lundmark
Specialty certification is an important method to demonstrate that RNs possess advanced training, knowledge, and competencies required to provide safe, high-quality care for specific populations.
May 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28415795/renal-sympathetic-denervation-guided-by-renal-nerve-stimulation-to-treat-ventricular-arrhythmia-in-ckd-patients-with-icd
#2
Márcio Galindo Kiuchi, Shaojie Chen, Luis Marcelo Rodrigues Paz, Helmut Pürerfellner
Chronic kidney disease (CKD) patients on stage 4 present greater risk rates for malignant ventricular arrhythmia events. This study examined patients with CKD in stages 1, 2, 3 and 4, left ventricular dysfunction and automatic implantable cardioverter-defibrillator (ICD). Our goal was to record the appropriate therapies, "Anti-tachycardia Therapy Pacing" (ATP) and shock events during the 18 months of follow-up and compare the incidence and severity of these at different stages of CKD, mainly in patients with CKD stage 4 underwent renal sympathetic denervation (RSD) guided by renal nerve stimulation (RNS)...
March 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414922/three-new-active-members-of-the-i-onui-family-of-homing-endonucleases
#3
Iman M Bilto, Tuhin Kumar Guha, Alvan Wai, Georg Hausner
In vitro characterization of three LAGLIDADG-type homing endonucleases (I-CcaI, I-CcaII and I-AstI) that belong to the I-OnuI family showed that they are functional homing endonucleases that cleave their respective cognate target sites. These endonucleases are encoded within group ID introns and appear to be orthologs that have inserted into three different mitochondrial genes, rns, rnl and cox3, respectively. The endonuclease activity of I-CcaI was tested using various substrates and its minimum DNA recognition sequence was estimated to be 26 nt...
April 17, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28411298/detecting-sepsis-are-two-opinions-better-than-one
#4
Poushali Bhattacharjee, Matthew M Churpek, Ashley Snyder, Michael D Howell, Dana P Edelson
The diagnosis of sepsis requires that objective criteria be met with a corresponding subjective suspicion of infection. We conducted a study to characterize the agreement between different providers' suspicion of infection and the correlation with patient outcomes using prospective data from a general medicine ward. Registered nurse (RN) suspicion of infection was collected every 12 hours and compared with medical doctor or advanced practice professional (MD/APP) suspicion, defined as an existing order for antibiotics or a new order for blood or urine cultures within the 12 hours before nursing screen time...
April 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28398072/the-reactive-species-interactome-evolutionary-emergence-biological-significance-and-opportunities-for-redox-metabolomics-and-personalized-medicine
#5
Miriam Margherita Cortese-Krott, Anne Koning, Gunter Georg Kuhnle, Peter Nagy, Christopher Bianco, Andreas Pasch, David A Wink, Jon Fukuto, Alan A Jackson, Harry van Goor, Kenneth R Olson, Martin Feelisch
SIGNIFICANCE: Oxidative stress is thought to account for aberrant redox homeostasis and contribute to aging and disease. However, more often than not administration of antioxidants is ineffective, suggesting our current understanding of the underlying regulatory processes is incomplete. Recent Advances. Similar to reactive oxygen and nitrogen species (ROS, RNS), reactive sulfur species (RSS) are now emerging as important signaling molecules, targeting regulatory cysteine redox switches in proteins, affecting gene regulation, ion transport, intermediary metabolism and mitochondrial function...
April 11, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28398014/brain-responsive-neurostimulation-in-patients-with-medically-intractable-mesial-temporal-lobe-epilepsy
#6
Eric B Geller, Tara L Skarpaas, Robert E Gross, Robert R Goodman, Gregory L Barkley, Carl W Bazil, Michael J Berg, Gregory K Bergey, Sydney S Cash, Andrew J Cole, Robert B Duckrow, Jonathan C Edwards, Stephan Eisenschenk, James Fessler, Nathan B Fountain, Alicia M Goldman, Ryder P Gwinn, Christianne Heck, Aamar Herekar, Lawrence J Hirsch, Barbara C Jobst, David King-Stephens, Douglas R Labar, James W Leiphart, W Richard Marsh, Kimford J Meador, Eli M Mizrahi, Anthony M Murro, Dileep R Nair, Katherine H Noe, Yong D Park, Paul A Rutecki, Vicenta Salanova, Raj D Sheth, Donald C Shields, Christopher Skidmore, Michael C Smith, David C Spencer, Shraddha Srinivasan, William Tatum, Paul C Van Ness, David G Vossler, Robert E Wharen, Gregory A Worrell, Daniel Yoshor, Richard S Zimmerman, Kathy Cicora, Felice T Sun, Martha J Morrell
OBJECTIVE: Evaluate the seizure-reduction response and safety of mesial temporal lobe (MTL) brain-responsive stimulation in adults with medically intractable partial-onset seizures of mesial temporal lobe origin. METHODS: Subjects with mesial temporal lobe epilepsy (MTLE) were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline...
April 11, 2017: Epilepsia
https://www.readbyqxmd.com/read/28396294/chronic-ambulatory-electrocorticography-from-human-speech-cortex
#7
Vikram R Rao, Matthew K Leonard, Jonathan K Kleen, Ben A Lucas, Emily A Mirro, Edward F Chang
Direct intracranial recording of human brain activity is an important approach for deciphering neural mechanisms of cognition. Such recordings, usually made in patients with epilepsy undergoing inpatient monitoring for seizure localization, are limited in duration and depend on patients' tolerance for the challenges associated with recovering from brain surgery. Thus, typical intracranial recordings, similar to most non-invasive approaches in humans, provide snapshots of brain activity in acute, highly constrained settings, limiting opportunities to understand long timescale and natural, real-world phenomena...
April 7, 2017: NeuroImage
https://www.readbyqxmd.com/read/28395819/evaluation-of-the-release-profile-stability-and-antioxidant-activity-of-a-proanthocyanidin-rich-cinnamon-cinnamomum-zeylanicum-extract-co-encapsulated-with-%C3%AE-tocopherol-by-spray-chilling
#8
Fabrício L Tulini, Volnei B Souza, Marcelo Thomazini, Marluci P Silva, Adna P Massarioli, Severino M Alencar, Eliria M J A Pallone, Maria I Genovese, Carmen S Favaro-Trindade
Cinnamon has many health improving compounds such as proanthocyanidins, which also have potential for the prevention of damages caused by diabetes. Similarly, α-tocopherol is a natural antioxidant with important role on protection of fatty acids in membranes and lipoproteins. However, the addition of antioxidants in food may result in interaction with food matrix, low stability and unpleasant taste. In the present study, a proanthocyanidin-rich cinnamon extract (PRCE) (Cinnamomum zeylanicum) was co-encapsulated with α-tocopherol into solid lipid microparticles (SLMs) by spray chilling...
May 2017: Food Research International
https://www.readbyqxmd.com/read/28394410/nanotechnology-for-electroanalytical-biosensors-of-reactive-oxygen-and-nitrogen-species
#9
REVIEW
Rajesh Seenivasan, Charles Kolodziej, Chandran Karunakaran, Clemens Burda
Over the past several decades, nanotechnology has contributed to the progress of biomedicine, biomarker discovery, and the development of highly sensitive electroanalytical / electrochemical biosensors for in vitro and in vivo monitoring, and quantification of oxidative and nitrosative stress markers like reactive oxygen species (ROS) and reactive nitrogen species (RNS). A major source of ROS and RNS is oxidative stress in cells, which can cause many human diseases, including cancer. Therefore, the detection of local concentrations of ROS (e...
April 10, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/28393947/production-of-doubly-charged-highly-reactive-species-from-the-long-chain-amino-acid-gaba-initiated-by-ar-9-ionization
#10
Dariusz Grzegorz Piekarski, Rudy Delaunay, Arkadiusz Mika, Sylvain Maclot, Lamri Adoui, Fernando Martín, Manuel Alcamí, Bernd A Huber, Patrick Rousseau, Sergio Díaz-Tendero, Alicja Domaracka
We present a combined experimental and theoretical study of the fragmentation of multiply-charged γ-aminobutyric acid molecules (GABA(z+), z = 2, 3) in the gas phase. The combination of ab initio molecular dynamics simulations with multiple-coincidence mass spectrometry techniques allows us to observe and identify doubly-charged fragments in coincidence with another charged moiety. The present results indicate that double and triple electron capture lead to the formation of doubly-charged reactive nitrogen and oxygen species (RNS and ROS) with different probabilities due to the different charge localisation and fragmentation behaviour of GABA(2+) and GABA(3+)...
April 10, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28391021/implantation-of-responsive-neurostimulation-for-epilepsy-using-intraoperative-ct-technical-nuances-and-accuracy-assessment
#11
Mena G Kerolus, Ryan B Kochanski, Marvin Rossi, Michael Stein, Richard W Byrne, Sepehr Sani
INTRODUCTION: Implantation of responsive neurostimulation (RNS) system has been previously discussed in the literature but there is a paucity of data on target accuracy and the use of intraoperative imaging. We describe our experience with eight patients using intraoperative computed tomography (iCT) during implantation of the NeuroPace(®) RNS system. METHODS: A frame based system was used. CT images were obtained and merged with preoperative MRI and metabolic imaging studies to calculate target coordinates...
April 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28389918/quantitative-analysis-of-the-cysteine-redoxome-by-iodoacetyl-tandem-mass-tags
#12
Shakir Shakir, Joelle Vinh, Giovanni Chiappetta
The redox conditions that reign inside a cell have a determining effect on a number of biological processes. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are key redox players and have been linked to a number of pathologies. They have also been shown to play an important regulating role in cell signaling events. On the proteome level, thiol groups of cysteinyl side chains constitute the major targets of ROS and RNS. A number of analytical techniques based on mass spectrometry have been developed to characterize the cysteine redoxome, often facing a number of technical challenges, mostly related to the lability, heterogeneity, and low abundance of the oxidized forms...
April 7, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28387951/brain-responsive-neurostimulation-in-patients-with-medically-intractable-seizures-arising-from-eloquent-and-other-neocortical-areas
#13
Barbara C Jobst, Ritu Kapur, Gregory L Barkley, Carl W Bazil, Michel J Berg, Gregory K Bergey, Jane G Boggs, Sydney S Cash, Andrew J Cole, Michael S Duchowny, Robert B Duckrow, Jonathan C Edwards, Stephan Eisenschenk, A James Fessler, Nathan B Fountain, Eric B Geller, Alica M Goldman, Robert R Goodman, Robert E Gross, Ryder P Gwinn, Christianne Heck, Aamr A Herekar, Lawrence J Hirsch, David King-Stephens, Douglas R Labar, W R Marsh, Kimford J Meador, Ian Miller, Eli M Mizrahi, Anthony M Murro, Dileep R Nair, Katherine H Noe, Piotr W Olejniczak, Yong D Park, Paul Rutecki, Vicenta Salanova, Raj D Sheth, Christopher Skidmore, Michael C Smith, David C Spencer, Shraddha Srinivasan, William Tatum, Paul Van Ness, David G Vossler, Robert E Wharen, Gregory A Worrell, Daniel Yoshor, Richard S Zimmerman, Tara L Skarpaas, Martha J Morrell
OBJECTIVE: Evaluate the seizure-reduction response and safety of brain-responsive stimulation in adults with medically intractable partial-onset seizures of neocortical origin. METHODS: Patients with partial seizures of neocortical origin were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline...
April 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/28385846/complete-genome-sequence-of-a-sub-subgenotype-2-1i-isolate-of-classical-swine-fever-virus-from-china
#14
Bikai Zhang, Shijiang Mi, Fei Bao, Huancheng Guo, Changchun Tu, Jishu Shi, Wenjie Gong
The complete genome sequence of a sub-subgenotype 2.1i isolate of classical swine fever virus (CSFV), GD317/2011, was determined. Notably, GD317/2011 is distant from the sub-subgenotype 2.1b isolate HEBZ at genes of E(rns), E1, E2, P7, NS2, NS5A and the 3'-nontranslated region (3'-NTR) but is closely related to that at genes of N(pro), Core, NS3, NS4A, NS4B, and NS5B.
April 6, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28366231/feasibility-of-the-translating-innovations-into-practice-toolbox-tip-toolbox-a-mixed-methods-study-for-implementing-activity-innovations-in-nursing-homes
#15
Nienke O Kuk, Gerrie J J W Bours, Jan P H Hamers, Gertrudis I J M Kempen, G A Rixt Zijlstra
This mixed-methods study evaluated the feasibility of the Translating Innovations into Practice (TIP)-toolbox. This toolbox guided nursing staff in 6 practical steps in developing a structured and tailored implementation plan to sustainably implement an innovation. For 9 weeks, 12 registered nurses (RNs) at 3 nursing homes in the Netherlands used the TIP-toolbox to develop an implementation plan related to promoting functional activity among nursing home residents. Data were collected by questionnaires, telephone interviews, participant observations, and focus group interviews...
March 30, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28364332/repetitive-nerve-stimulation-as-a-diagnostic-aid-for-distinguishing-cervical-spondylotic-amyotrophy-from-amyotrophic-lateral-sclerosis
#16
Chaojun Zheng, Xiang Jin, Yu Zhu, Feizhou Lu, Jianyuan Jiang, Xinlei Xia
PURPOSE: To identify and compare the features of compound muscle action potential (CMAP) decrements in repetitive nerve stimulation (RNS) in patients with cervical spondylotic amyotrophy (CSA) and in patients with amyotrophic lateral sclerosis (ALS). METHODS: The cohort consisted of 43 CSA (distal-type to proximal-type ratio: 27-16) and 35 ALS patients. Five muscles, including abductor pollicis brevis (APB), abductor digiti minimi (ADM), biceps brachii (BB), middle deltoid (Del), and upper trapezius (Trap), were tested by 3-Hz RNS...
March 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28362462/impact-of-accreditation-standards-on-the-quality-of-continuing-nursing-education-activities-as-perceived-by-the-learner
#17
Elaine M Novakovich
BACKGROUND: Continuing nursing education (CNE) activities are increasingly becoming a requirement for RNs to maintain licensure or certification and to remain competent in practice in the fast-changing health care environment. Regardless of the health care profession, continuing education should be a quality educational experience to positively influence practice and patient outcomes. METHOD: A 15-item matrix based on the 2013 American Nurses Credentialing Center Primary Accreditation criteria was used to evaluate CNE activities...
April 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28362454/bodipy-blocked-anthroxyl-radicals-the-substituent-effect-on-reactivity-and-fluorescence-turn-on-detection-of-a-hydroxyl-radical
#18
Fang Miao, Zheng Long Lim, Pan Hu, Shaoqiang Dong, Qingbiao Qi, Xiaojie Zhang, Jishan Wu
Two BODIPY-substituted anthroxyl radicals were investigated. The one with two ethyl substituents (2Et-BO-An-O) is sensitive to air and silica gel due to the lack of sufficient kinetic blocking, while another one with four methyl substituents (4Me-BO-An-O) shows high stability. The structure of the latter was fully characterized by X-ray crystallographic analysis and electron-spin resonance spectra. 4Me-BO-An-O was subjected to react with various reactive oxygen/nitrogen species (ROS/RNS) and selective fluorescence turn-on detection of a hydroxyl radical was achieved, validating the concept of "using stable radicals to detect ROS/RNS"...
April 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28358581/mechanism-of-the-antitumor-and-radiosensitizing-effects-of-a-manganese-porphyrin-mnhex-2-pyp
#19
Sung-Won Shin, Changhoon Choi, Ga-Haeng Lee, Arang Son, Su-Hyeon Kim, Hee Chul Park, Ines Batinic-Haberle, Won Park
AIMS: Cationic manganese (Mn)-substituted N-pyridylporphyrin-based potent mimics of the family of superoxide dismutases (SODs) protect normal tissues from injury related to ionizing radiation (IR) by reducing levels of reactive oxygen and nitrogen species (ROS/RNS). Furthermore, Mn-porphyrins have demonstrated antitumor and radiosensitizing effects on cancer cells by promoting IR-induced tumor vasculature damage and apoptotic processes. In this study, we explored the underlying mechanisms of Mn-porphyrin-mediated tumor radiosensitization using murine mammary carcinoma 4T1 and melanoma B16 cells in vitro and in vivo...
March 30, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28353470/the-impact-of-nursing-leader-s-behavioral-integrity-and-intragroup-relationship-conflict-on-staff-nurses-intention-to-remain
#20
Seung-Wan Kang, Soojin Lee, Suk Bong Choi
OBJECTIVE: This study tested a multilevel model examining the effect of nursing leader's behavioral integrity and intragroup relationship conflict on staff nurses' intent to remain. BACKGROUND: In the challenging situation of nursing shortage, nurse executives are required to focus on the retention of nurses. No previous studies have examined the impact of nursing leader's behavioral integrity and intragroup relationship conflict on nurses' intention to remain. METHODS: A cross-sectional survey of 480 RNs in 34 nursing units of a large public hospital in South Korea was conducted to test the hypothesized multilevel model...
May 2017: Journal of Nursing Administration
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