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https://www.readbyqxmd.com/read/28727627/associations-of-organizational-safety-practices-and-culture-with-physical-workload-perceptions-about-work-and-work-related-injury-and-symptoms-among-hospital-nurses
#1
Soo-Jeong Lee, Joung Hee Lee
OBJECTIVE: The study aim was to examine the relationships of organizational safety practices with nurses' perceptions about job and risk and experiences of work-related injury and symptoms. BACKGROUND: Nursing professions report high rates of work-related injuries. Organizational safety practices have been linked to workers' safety outcomes and perceptions about work. METHODS: This study analyzed data from a random sample of 280 California RNs in a cross-sectional statewide survey...
July 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28727622/an-innovative-academic-service-partnership-to-increase-bsn-prepared-rns-in-a-rural-hospital
#2
Michelle H Cheshire, Cassandra D Ford, Yvette Daidone
Developing innovative ways to increase BSN-prepared nurses in hospitals in rural regions is a struggle. A partnership between 1 hospital and a local university to support the associate-degree new graduates to progress toward their BSN is proving to be a success.
July 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28725108/identification-of-the-linear-ligand-epitope-on-classical-swine-fever-virus-that-interacts-with-porcine-kidney-15-cells
#3
Yin Mei, Feng Yue, Hong-Mei Ning, Juan-Juan Zhou, Xuan-Nian Wang
Binding of the viral ligand to a specific receptor is the first step of virus entry into target cells. The envelope proteins E(rns), E1, and E2 of classical swine fever virus (CSFV) are involved in the interaction with host cell receptors to mediate CSFV infection. The aim of this investigation was to identify epitopes that bind to porcine kidney (PK)-15 cells to prevent CSFV infection. Ten peptides representing E(rns), E1, and E2 were synthesized. Immunohistochemical study showed that the SE24 peptide, which is derived from the E2 amino acid sequence, could effectively bind to PK-15 cells...
July 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28720229/perioperative-registered-nurses-knowledge-attitudes-behaviors-and-barriers-regarding-pressure-ulcer-prevention-in-perioperative-patients
#4
Peggy C Tallier, Patricia R Reineke, Kathy Asadoorian, John G Choonoo, Marc Campo, Christine Malmgreen-Wallen
BACKGROUND: Hospital acquired pressure ulcers have a detrimental effect on patient quality of life, morbidity, mortality, and cost to the healthcare industry. Little is known about pressure ulcer prevention in perioperative services. OBJECTIVES: The objectives of this study were to describe perioperative registered nurses (RNs) knowledge, attitudes, behaviors, and barriers about pressure ulcer prevention and to determine if knowledge and the availability of a pressure ulcer staging tool are predictors of pressure ulcer prevention behavior...
August 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28717275/initial-experience-of-robotic-nephron-sparing-surgery-in-cases-of-high-renal-nephrometry-scores
#5
Girdhar S Bora, Ravimohan S Mavuduru, Aditya P Sharma, Sudheer K Devana, Nandita Kakkar, Anupam Lal, Shrawan K Singh, Arup K Mandal
INTRODUCTION: The renal nephrometry scoring (RNS) system enables prediction the feasibility of nephron-sparing surgery (NSS) in renal masses. There is insufficient data regarding the outcome of robot-assisted NSS in tumors with RNS ≥10. We reviewed the trifecta outcomes of patients undergoing robotic NSS with high RNS and compare it with tumors of low and intermediate RNS. MATERIALS AND METHODS: Our prospectively maintained data of all robot-assisted NSS were reviewed, and those with RNS of ≥10 were identified...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28715730/redox-regulation-of-proteasome-function
#6
Maria Lefaki, Nikoletta Papaevgeniou, Niki Chondrogianni
Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations...
July 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28713400/overexpression-of-e3-ubiquitin-ligase-gene-adbil-contributes-to-resistance-against-chilling-stress-and-leaf-mold-disease-in-tomato
#7
Shuangchen Chen, Hongjiao Zhao, Mengmeng Wang, Jidi Li, Zhonghong Wang, Fenghua Wang, Airong Liu, Golam J Ahammed
Ubiquitination is a common regulatory mechanism, playing a critical role in diverse cellular and developmental processes in eukaryotes. However, a few reports on the functional correlation between E3 ubiquitin ligases and reactive oxygen species (ROS) or reactive nitrogen species (RNS) metabolism in response to stress are currently available in plants. In the present study, the E3 ubiquitin ligase gene AdBiL (Adi3 Binding E3 Ligase) was introduced into tomato line Ailsa Craig via Agrobacterium-mediated method...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28712526/occupational-disappointment-why-did-i-even-become-a-nurse
#8
Rebekah J Howerton Child, Elizabeth J Sussman
INTRODUCTION: The aim of this study was to identify patterns of feelings and behavior of ED RNs who have experienced verbal workplace violence. METHODS: Twenty-eight registered nurses from across the state of California were recruited. Data were collected, using in-depth interviews, and were recorded. The tapes were transcribed and analyzed using Glaserian grounded-theory methodology. RESULTS: The main experiences of participants included occupational disappointment, peer support, lack of preparation by mandatory violence prevention classes, and unrealistic patient expectations...
July 13, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/28704501/reduced-susceptibility-of-clinical-strains-of-mycobacterium-tuberculosis-to-reactive-nitrogen-species-promotes-survival-in-activated-macrophages
#9
Jonna Idh, Blanka Andersson, Maria Lerm, Johanna Raffetseder, Daniel Eklund, Hanna Woksepp, Jim Werngren, Mikael Mansjö, Tommy Sundqvist, Olle Stendahl, Thomas Schön
BACKGROUND: Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical strains of M. tuberculosis. METHOD: Luciferase-expressing clinical M. tuberculosis strains with or without INH resistance were exposed to RNS donors (DETA/NO and SIN-1) in broth cultures and bacterial survival was analysed by luminometry...
2017: PloS One
https://www.readbyqxmd.com/read/28702859/spirulina-platensis-prevents-high-glucose-induced-oxidative-stress-mitochondrial-damage-mediated-apoptosis-in-cardiomyoblasts
#10
Pratiksha Jadaun, Dhananjay Yadav, Prakash Singh Bisen
The current study was undertaken to study the effect of Spirulina platensis (Spirulina) extract on enhanced oxidative stress during high glucose induced cell death in H9c2 cells. H9c2 cultured under high glucose (33 mM) conditions resulted in a noteworthy increase in oxidative stress (free radical species) accompanied by loss of mitochondrial membrane potential, release of cytochrome c, increase in caspase activity and pro-apoptotic protein (Bax). Spirulina extract (1 μg/mL), considerably inhibited increased ROS and RNS levels, reduction in cytochrome c release, raise in mitochondrial membrane potential, decreased the over expression of proapoptotic protein Bax and suppressed the Bax/Bcl2 ratio with induced apoptosis without affecting cell viability...
July 12, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28700075/south-korean-family-caregiver-involvement-in-delirium-care-a-qualitative-descriptive-study
#11
Yun Kang, Wendy Moyle, Marie Cooke, Siobhan O'Dwyer
The current study aimed to describe the effect of an educational program on RN-initiated efforts to involve family caregivers in delirium care. A descriptive qualitative study was performed. A purposive sample of 12 RNs who participated in a one group, pre-post evaluation of a delirium educational program, and a nominated sample of six family caregivers of patients who had been cared for by RNs in the program participated in individual, in-depth interviews. The qualitative findings indicated that the inclusion of a delirium brochure in ward orientation on admission, with reinforcement during shift changes, and RN-initiated engagement with family caregivers promoted family caregiver involvement in delirium prevention...
July 12, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28698499/molecular-mechanisms-behind-free-radical-scavengers-function-against-oxidative-stress
#12
REVIEW
Fereshteh Ahmadinejad, Simon Geir Møller, Morteza Hashemzadeh-Chaleshtori, Gholamreza Bidkhori, Mohammad-Saeid Jami
Accumulating evidence shows that oxidative stress is involved in a wide variety of human diseases: rheumatoid arthritis, Alzheimer's disease, Parkinson's disease, cancers, etc. Here, we discuss the significance of oxidative conditions in different disease, with the focus on neurodegenerative disease including Parkinson's disease, which is mainly caused by oxidative stress. Reactive oxygen and nitrogen species (ROS and RNS, respectively), collectively known as RONS, are produced by cellular enzymes such as myeloperoxidase, NADPH-oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) and nitric oxide synthase (NOS)...
July 10, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28696480/a-picture-is-worth-1-000-words-the-use-of-clinical-images-in-electronic-medical-records
#13
Angela C Ai, Francine L Maloney, Thu-Trang Hickman, Allison R Wilcox, Harley Ramelson, Adam Wright
OBJECTIVE: To understand how clinicians utilize image uploading tools in a home grown electronic health records (EHR) system. METHODS: A content analysis of patient notes containing non-radiological images from the EHR was conducted. Images from 4,000 random notes from July 1, 2009 - June 30, 2010 were reviewed and manually coded. Codes were assigned to four properties of the image: (1) image type, (2) role of image uploader (e.g. MD, NP, PA, RN), (3) practice type (e...
July 12, 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/28688989/involvement-of-oxidative-stress-and-calcium-signaling-in-airborne-particulate-matter-induced-damages-in-human-pulmonary-artery-endothelial-cells
#14
J Deweirdt, J F Quignard, B Crobeddu, A Baeza-Squiban, J Sciare, A Courtois, S Lacomme, E Gontier, B Muller, J P Savineau, R Marthan, C Guibert, I Baudrimont
Recent studies have revealed that particulate matter (PM) exert deleterious effects on vascular function. Pulmonary artery endothelial cells (HPAEC), which are involved in the vasomotricity regulation, can be a direct target of inhaled particles. Modifications in calcium homeostasis and oxidative stress are critical events involved in the physiopathology of vascular diseases. The objectives of this study were to assess the effects of PM2.5 on oxidative stress and calcium signaling in HPAEC. Different endpoints were studied, (i) intrinsic and intracellular production of reactive oxygen species (ROS) by the H2DCF-DA probe, (ii) intrinsic, intracellular and mitochondrial production of superoxide anion (O2(-)) by electronic paramagnetic resonance spectroscopy and MitoSOX probe, (iii) reactive nitrosative species (RNS) production by Griess reaction, and (vi) calcium signaling by the Fluo-4 probe...
July 5, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28688346/improved-detection-of-bovine-viral-diarrhea-virus-in-bovine-lymphoid-cell-lines-using-primeflow-rna-assay
#15
Shollie M Falkenberg, Rohana P Dassanayake, John D Neill, Julia F Ridpath
Bovine viral diarrhea virus (BVDV) infections, whether as acute, persistent or contributing to co-infections, result in significant losses for cattle producers. Although, BVDV can be identified readily by real-time PCR and ELISA, detection and quantification of viral infection at the single cell level is extremely difficult. Detection at the single lymphoid cell level is important due to the immunomodulation that accompanies BVDV infection. A novel PrimeFlow RNA assay using in-situ detection of BVDV was evaluated...
September 2017: Virology
https://www.readbyqxmd.com/read/28685789/orchestration-of-dynamic-copper-navigation-new-and-missing-pieces
#16
REVIEW
Helena Öhrvik, Jan Aaseth, Nina Horn
A general principle in all cells in the body is that an essential metal - here copper - is taken up at the plasma membrane, directed through cellular compartments for use in specific enzymes and pathways, stored in specific scavenging molecules if in surplus, and finally expelled from the cells. Here we attempt to provide a critical view on key concepts involved in copper transfer across membranes and through compartments in the human body. The focus of this review is on the influence of bioinorganic and thermodynamic rules on the flow in cellular copper networks...
July 7, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28685524/colorectal-cancer-an-update-on-the-effects-of-lycopene-on-tumor-progression-and-cell-proliferation
#17
F Carini, S David, G Tomasello, M Mazzola, P Damiani, F Rappa, L Battaglia, A Gerges Geagea, R Jurjus, A Leone
Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways...
September 30, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28684719/reactive-oxygen-and-nitrogen-species-in-the-development-of-pulmonary-hypertension
#18
REVIEW
David J R Fulton, Xueyi Li, Zsuzsanna Bordan, Stephen Haigh, Austin Bentley, Feng Chen, Scott A Barman
Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that involves the loss of endothelial function together with inappropriate smooth muscle cell growth, inflammation, and fibrosis. These changes underlie a progressive remodeling of blood vessels that alters flow and increases pulmonary blood pressure. Elevated pressures in the pulmonary artery imparts a chronic stress on the right ventricle which undergoes compensatory hypertrophy but eventually fails. How PAH develops remains incompletely understood and evidence for the altered production of reactive oxygen and nitrogen species (ROS, RNS respectively) in the pulmonary circulation has been well documented...
July 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28677495/strategies-to-reduce-oxidative-stress-in-glaucoma-patients
#19
M D Pinazo-Durán, K Shoaie-Nia, V Zanón-Moreno, S M Sanz-González, Benítez Del Castillo J, J J García-Medina
Primary open-angle glaucoma (POAG) is a multifactorial pathology involving a variety of pathogenic mechanisms, including oxidative/nitrosative stress. This latter is the consequence of the imbalance between excessive formation and insufficient protection against reactive oxygen/nitrogen species (ROS/RNS). Our main goal is to gather molecular information to better managing variants that may determine the individual susceptibility to oxidative/nitrosative stress and POAG. We also review the experimental glaucoma models as well as the clinical trials that may help understanding the role of antioxidants, essential fatty acids, natural compounds and other similar strategies for counteracting oxidative/nitrosative stress in glaucoma that may modulate disease susceptibility or attenuate its progression...
July 5, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28676723/analysis-of-reactive-oxygen-and-nitrogen-species-generated-in-three-liquid-media-by-low-temperature-helium-plasma-jet
#20
Julie Chauvin, Florian Judée, Mohammed Yousfi, Patricia Vicendo, Nofel Merbahi
In order to identify aqueous species formed in Plasma activated media (PAM), quantitative investigations of reactive oxygen and nitrogen species (ROS, RNS) were performed and compared to Milli-Q water and culture media without and with Fetal Calf Serum. Electron paramagnetic resonance, fluorometric and colorimetric analysis were used to identify and quantify free radicals generated by helium plasma jet in these liquids. Results clearly show the formation of ROS such as hydroxyl radical, superoxide anion radical and singlet oxygen in order of the micromolar range of concentrations...
July 4, 2017: Scientific Reports
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