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https://www.readbyqxmd.com/read/28817986/formation-of-artifactual-dmpo-oh-spin-adduct-in-acid-solutions-containing-nitrite-ions
#1
Tetsuya Takayanagi, Hirokazu Kimiya, Tatsushi Ohyama
We investigated aqueous solutions containing nitrite ions and DMPO (5,5-dimethyl-1-pyrroline-N-oxide) by ESR (Electron Spin Resonance) in the pH range from 1 to 6. A DMPO -OH signal was observed below pH 3.0 in the presence of nitrite ions, whereas in the absence of nitrite ion, an extremely weak signal was observed below pH 1.5. Addition of methanol, a hydroxyl radical scavenger, to this system did not lead to the appearance of a detectable DMPO-CH2OH signal. The possibility of this DMPO-OH signal being due to a genuine spin trapping process with hydroxyl radical was therefore ruled out...
August 17, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28817952/professional-socialization-a-grounded-theory-of-the-clinical-reasoning-processes-that-rns-and-lpns-use-to-recognize-delirium
#2
Mohamed El Hussein, Sandra Hirst, Joseph Osuji
Delirium is an acute disorder of attention and cognition. It affects half of older adults in acute care settings and is a cause of increasing mortality and costs. Registered nurses (RNs) and licensed practical nurses (LPNs) frequently fail to recognize delirium. The goals of this research were to identify the reasoning processes that RNs and LPNs use to recognize delirium, to compare their reasoning processes, and to generate a theory that explains their clinical reasoning processes. Theoretical sampling was employed to elicit data from 28 participants using grounded theory methodology...
August 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/28817520/renew-wyoming-s-answer-to-academic-progression-in-nursing
#3
Jennifer Anderson, Kathy Wells, Charlotte Mather, Mary E Burman
AIM: The aim of the study was to describe Wyoming's approach to academic progression and its projected impact. The collaborative process used to develop the shared statewide BSN curriculum is described along with recommendations. BACKGROUND: Successful educational models that address the Institute of Medicine's recommendation that 80 percent of RNs have a baccalaureate degree by 2020 face numerous challenges, especially in rural states. METHOD: ReNEW (Revolutionizing Nursing Education in Wyoming) is a creative solution designed to decrease barriers to BSN education and increase motivation through a streamlined shared curriculum building on a strong community college system and the state's one BSN program...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28817519/maryland-action-coalition-academic-progression-takes-several-pathways
#4
Rebecca Wiseman, Nina M Trocky, Patricia T Travis, Jane Marie Kirschling
AIM: The purpose of this article is to provide an overview of the Maryland Action Coalition academic progression activities. BACKGROUND: Maryland is predicted to be one of four states that will experience a shortage of 10,000 or more registered nurses in 2025. The Maryland Action Coalition has committed to the Institute of Medicine's Future of Nursing recommendation that 80 percent of nurses be educated at the baccalaureate (or higher) level. METHOD: Various approaches to seamless academic progression are described...
September 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28816712/nurses-knowledge-and-teaching-of-possible-postpartum-complications
#5
Patricia D Suplee, Debra Bingham, Lisa Kleppel
PURPOSE: The purpose of this study was to assess postpartum nurses' knowledge of maternal morbidity and mortality, and information they shared with women before discharge about identifying potential warning signs of postpartum complications. STUDY DESIGN & METHODS: Registered nurses (RNs) who care for women during postpartum (N = 372) completed an electronic survey. Descriptive statistics and bivariate analyses were used for data analysis. RESULTS: Fifteen percent of nurse participants were aware of the current rate of maternal mortality in the United States and 12% accurately reported the correct percentage of deaths that occurred during the postpartum period...
August 15, 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28812844/clinician-perspectives-of-barriers-to-effective-implementation-of-a-rapid-response-system-in-an-academic-health-centre-a-focus-group-study
#6
John Rihari-Thomas, Michelle DiGiacomo, Jane Phillips, Phillip Newton, Patricia M Davidson
BACKGROUND: Systemic and structural issues of rapid response system (RRS) models can hinder implementation. This study sought to understand the ways in which acute care clinicians (physicians and nurses) experience and negotiate care for deteriorating patients within the RRS. METHODS: Physicians and nurses working within an Australian academic health centre within a jurisdictional-based model of clinical governance participated in focus group interviews. Verbatim transcripts were analysed using thematic content analysis...
January 1, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28809456/real-time-intracellular-measurements-of-ros-and-rns-in-living-cells-with-single-core-shell-nanowire-electrodes
#7
Xin-Wei Zhang, Quan-Fa Qiu, Hong Jiang, Fu-Li Zhang, Yan-Ling Liu, Christian Amatore, Wei-Hua Huang
Nanoelectrodes allow precise and quantitative measurements of important biological processes at the single living cell level in real time. Cylindrical nanowires electrodes (NWEs) required for intracellular measurements create a great challenge for keeping excellent electrochemical and mechanical performances. Herein, we disclose a facile and robust solution to this problem based on a SiC-core-shell unique design to produce cylindrical NWEs with superior mechanical toughness provided by the SiC nano-core and excellent electrochemical performances brought by the ultrathin carbon shell that can be used as such or platinized...
August 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28808388/caesalpinia-crista-linn-induces-protection-against-dna-and-membrane-damage
#8
R Sunil Kumar, Ramesh Balenahalli Narasingappa, Chandrashekhar G Joshi, Talakatta K Girish, Ananda Danagoudar
BACKGROUND: Caesalpinia crista is a medicinal herb used to cure various ailments in subtropical and tropical regions of Southeast Asia. OBJECTIVE: The objective of this evaluation of C. crista against free radical induced DNA and erythrocyte damage. MATERIALS AND METHODS: The profiles of polyphenol and flavonoid were quantified through reversed-phase high-performance liquid chromatography. Free radical induced DNA and membrane damage were performed using H2O2 as oxidative agent...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28795608/focus-small-to-find-big-the-microbeam-story
#9
Jinhua Wu, Tom K Hei
PURPOSE: Even though the first ultraviolet microbeam was described by S. Tschachotin back in 1912, the development of sophisticated micro-irradiation facilities only began to flourish in the late 1980s. In this article, we highlight significant microbeam experiments, describe the latest microbeam irradiator configurations and critical discoveries made by using the microbeam apparatus. MATERIALS AND METHODS: Modern radiological microbeams facilities are capable of producing a beam size of a few micrometers, or even tens of nanometers in size, and can deposit radiation with high precision within a cellular target...
August 10, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28795583/regulation-of-cell-survival-apoptosis-and-epithelial-to-mesenchymal-transition-by-nitric-oxide-dependent-post-translational-modifications
#10
Raul González, Francisco J Molina-Ruiz, Jose Antonio Barcena Ruiz, C Alicia Padilla, Jordi Muntané
SIGNIFICANCE: Nitric oxide (NO) is a physiopathological messenger generating different reactive nitrogen species (RNS) according to hypoxic, acidic and redox conditions. Recent Advances: RNS and reactive oxygen species (ROS) promote relevant post-translational modifications, such as nitrosation, nitration and oxidation, in critical components of cell proliferation and death, epithelial to mesenchymal transition and metastasis. CRITICAL ISSUES: The pro- or antitumoral properties of NO are dependent on local concentration, redox state, cellular status, duration of exposure and compartmentalization of NO generation...
August 10, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28794554/mucocutaneous-manifestations-in-patients-with-rheumatoid-arthritis-a-cross-sectional-study-from-eastern-india
#11
Sudip Kumar Ghosh, Debabrata Bandyopadhyay, Surajit Kumar Biswas, Ivoreen Darung
BACKGROUND: Cutaneous manifestations are fairly common in rheumatoid arthritis (RA) and they can help in early diagnosis, prompt treatment, and hence reduced morbidity from the disease. AIMS: The objective of the present study was to find out the different patterns of dermatoses in a group of patients with RA from Eastern India. METHODOLOGY: Consecutive patients fulfilling the American Rheumatism Association 1987 revised criteria for the classification of RA and who had different dermatoses were included in this cross-sectional study done over a period of 8 years in a tertiary care hospital in Eastern India...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28794220/is-behavioural-plasticity-consistent-across-different-environmental-gradients-and-through-time
#12
David J Mitchell, Peter A Biro
Despite accumulating evidence for individual variation in behavioural plasticity, there is currently little understanding of the causes and consequences of this variation. An outstanding question is whether individual reaction norm (RN) slopes are consistent across different environmental variables-that is, whether an individual that is highly responsive to one environmental variable will be equally responsive to a second variable. Another important and related question is whether RNs are themselves consistently expressed through time or whether they are simply state dependent...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28780847/-characteristics-of-repetitive-nerve-stimulation-in-53-cases-of-amyotrophic-lateral-sclerosis
#13
W X Liu, Z H Chen, L Ling, Y T Ren, B Sun, F Yang, F Cui, X S Huang
Objective: To investigate the feature of repetitive nerve stimulation (RNS) in patients with amyotrophic lateral sclerosis (ALS) and correlation between RNS and clinical features and electromyography (EMG) findings of the corresponding muscle. Methods: Needle EMG and RNS were performed in 53 patients with ALS, who were recruited into Department of Neurology of Chinese PLA general hospital during April to December in 2016. Decrement of the compond muscle action potential (CMAP) in response to RNS of different nerves and stimulus frequencies was compared...
August 1, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28776104/heat-or-cold-priming-induced-cross-tolerance-to-abiotic-stresses-in-plants-key-regulators-and-possible-mechanisms
#14
REVIEW
Mohammad Anwar Hossain, Zhong-Guang Li, Tahsina Sharmin Hoque, David J Burritt, Masayuki Fujita, Sergi Munné-Bosch
Plants growing under field conditions are constantly exposed, either simultaneously or sequentially, to more than one abiotic stress factor. Plants have evolved sophisticated sensory systems to perceive a number of stress signals that allow them to activate the most adequate response to grow and survive in a given environment. Recently, cross-stress tolerance (i.e. tolerance to a second, strong stress after a different type of mild primary stress) has gained attention as a potential means of producing stress-resistant crops to aid with global food security...
August 4, 2017: Protoplasma
https://www.readbyqxmd.com/read/28771947/roles-and-functions-of-enrolled-nurses-in-australia-perspectives-of-enrolled-nurses-and-registered-nurses
#15
Ruth Endacott, Margaret O'Connor, Allison Williams, Pamela Wood, Lisa McKenna, Debra Griffiths, Cheryle Moss, Phillip Della, Wendy Cross
AIMS: The aims of the study were: To determine, from the perspectives of Enrolled Nurses (ENs) and Registered Nurses (RNs), the current scope of EN practice and To identify the activities that most ENs frequently performed in their workplace. BACKGROUND: Enrolled Nurse scope of practice in Australia has evolved and expanded over the past decade. However, the unclear role, function and competency differentiation between EN and RN leads to role confusion and ongoing professional debate...
August 3, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28770542/process-based-treatment-of-diabetes-in-kaiser-permanente-southern-california-how-to-make-diabetes-care-complete
#16
REVIEW
John P Martin, Natalie Aboubechara
PURPOSE OF REVIEW: The purpose of this review was to provide an overview of the Kaiser Permanente Southern California (KPSC) Complete Care management strategy. RECENT FINDINGS: The KPSC Complete Care program allows members of care management teams to coordinate the administration of care for patients with diabetes. This program encompasses teams of physicians, physician assistants, pharmacists, nurse practitioners, registered nurse (RN) care managers, office-based RNs, health educators, and many others to contribute to the glycemic and overall health outcomes for our patients with diabetes...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28766385/paracetamol-overdose-induced-oxidative-stress-toxicity-metabolism-and-protective-effects-of-various-compounds-in-vivo-and-in-vitro
#17
Xu Wang, Qinghua Wu, Aimei Liu, Arturo Anadón, José-Luis Rodríguez, María-Rosa Martínez-Larrañaga, Zonghui Yuan, María-Aránzazu Martínez
Paracetamol (APAP) is one of the most widely used and popular over-the-counter analgesic and antipyretic drugs in the world when used at therapeutic doses. APAP overdose can cause severe liver injury, liver necrosis and kidney damage in human beings and animals. Many studies indicate that oxidative stress is involved in the various toxicities associated with APAP, and various antioxidants were evaluated to investigate their protective roles against APAP-induced liver and kidney toxicities. To date, almost no review has addressed the APAP toxicity in relation to oxidative stress...
August 16, 2017: Drug Metabolism Reviews
https://www.readbyqxmd.com/read/28761559/toxicity-and-apoptosis-related-effects-of-benzimidazo-3-2-%C3%AE-quinolinium-salts-upon-human-lymphoma-cells
#18
Christian Vélez, Jessica Soto, Karoline Ríos, Luz Silva, Wigberto Hernandez, Luis A Rivera, Ana I Ortiz-Colón, Osvaldo Cox, Beatriz Zayas
OBJECTIVES: The present study evaluates novel cationic quinoline derivatives known as benzimidazo[3,2-a]quinolinium salts (BQS) named NBQ-48 and ABQ-48 that have structural similarities to known anti-cancer substances such as ellipticine and berberine. METHODS: Toledo human lymphoma (ATCC CRL2631) cells were treated for 24 to 48 hours. Apoptosis related endpoints such as cell cycle arrest, mitochondrial damage, RNS and ROS generation and the activity of several apoptosis related proteins such as caspases and apoptosis inducing factor (AIF) were studied using fluorescence staining and western blot respectively...
2017: Open Medicinal Chemistry Journal
https://www.readbyqxmd.com/read/28759691/educational-intervention-for-clinical-judgment-skills
#19
May Lan Foo, Li Yoong Tang, Ramoo Vimala, Ping Lei Chui, Mei Chan Chong
BACKGROUND: Because nurses need to handle a broad range of issues related to patients' health status, it is necessary to make reliable and sound clinical judgments for professional accountability and the patients' safety. METHOD: A quasi-experimental pre- and posttest design with a control group was used to study the effectiveness of an educational intervention on the clinical judgment skills of 80 RNs from two district hospitals. The change in clinical judgment skills during a 6-week period was evaluated using a complex case-based scenario after the completion of the educational intervention...
August 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/28759688/the-nursing-professional-development-practitioner-and-rn-retention
#20
Jean Shinners
Nursing professional development practitioners spend time and energy on the education and career development of RNs, but are there strategies that can be used to support the retention of experienced staff? This article examines the use of a professional development assessment tool as a discussion for career pathway support and RN retention. J Contin Educ Nurs. 2017;48(8):340-342.
August 1, 2017: Journal of Continuing Education in Nursing
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