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https://www.readbyqxmd.com/read/27913033/nurse-practitioner-prescribing-in-australia-a-comprehensive-literature-review
#1
REVIEW
Jacqueline Fong, Thomas Buckley, Andrew Cashin, Lisa Pont
BACKGROUND: In Australia, the nurse practitioner (NP) obtained prescriptive authority in some jurisdictions in 2001. One of the key aspects in which the scope of NPs differs from Registered Nurses (RNs) relates to the legal privilege to prescribe medications. Although NPs have had prescriptive authority in Australia since 2001, with access to the Commonwealth subsidy scheme (PBS) since 2010, little is known about NPs prescriptive patterns or outcomes of prescriptive practice. AIM: The aim of this scoping review was to examine the extent, range and nature of research conducted in relation to NP prescribing in the Australian health context as well as identify gaps in the existing literature...
November 29, 2016: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/27906479/knowledge-and-practice-in-cardiovascular-disease-prevention-among-hospital-registered-nurses-a-cross-sectional-study
#2
Shu Ding, Ying Deng, Sai Lu, Karen V Lamb, Ying Zhang, Ying Wu
AIMS AND OBJECTIVES: To investigate the knowledge and clinical practices of cardiovascular disease (CVD) prevention among registered nurses (RNs) who worked on three major clinical units in Beijing hospitals. BACKGROUND: Health education on CVD prevention is an important component of nursing practice, however, Chinese RNs' knowledge and practice patterns have been poorly explored in previous studies. DESIGN: A cross-sectional study. METHODS: A stratified random sample of three hundred RNs was recruited from two tertiary hospitals in Beijing, China...
December 1, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27903582/threshold-levels-of-extracellular-l-arginine-that-trigger-nos-mediated-ros-rns-production-in-cardiac-ventricular-myocytes
#3
Jayalakshmi Ramachandran, R Daniel Peluffo
L-arginine (L-Arg) is the substrate for nitric oxide synthase (NOS) to produce nitric oxide (NO), a signaling molecule that is key in cardiovascular physiology and pathology. In cardiac myocytes, L-Arg is incorporated from the circulation through the functioning of system-y(+) cationic amino acid transporters. Depletion of L-Arg leads to NOS uncoupling, with O2 rather than L-Arg as terminal electron acceptor, resulting in superoxide formation. The reactive oxygen species (ROS) superoxide (O2•(-)), combined with NO, may lead to the production of the reactive nitrogen species (RNS) peroxynitrite (ONOO-), which is recognized as a major contributor to myocardial depression...
November 30, 2016: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/27902438/dna-double-strand-break-repair-is-involved-in-desiccation-resistance-of-sinorhizobium-meliloti-but-is-not-essential-for-its-symbiotic-interaction-with-medicago-truncatula
#4
Pierre Dupuy, Benjamin Gourion, Laurent Sauviac, Claude Bruand
The soil bacterium Sinorhizobium meliloti, a nitrogen-fixing symbiont of legume plants, is exposed to numerous stress conditions in nature, some of which cause the formation of harmful DNA double strand breaks (DSB). In particular, the reactive oxygen (ROS) and nitrogen (RNS) species produced during symbiosis, and the desiccation occurring in dry soils, are conditions which induce DSB. Two major systems of DSB repair are known in S. meliloti: homologous recombination (HR) and non-homologous end-joining (NHEJ)...
November 23, 2016: Microbiology
https://www.readbyqxmd.com/read/27900598/oxidative-stress-mediated-hippocampal-neuron-apoptosis-participated-in-carbon-disulfide-induced-rats-cognitive-dysfunction
#5
Shuo Wang, Gleniece Irving, Lulu Jiang, Hui Wang, Ming Li, Xujing Wang, Wenting Han, Yongpeng Xu, Yilin Yang, Tao Zeng, Fuyong Song, Xiulan Zhao, Keqin Xie
Occupational exposure to carbon disulfide (CS2) exhibits central nervous systems toxicity. But the mechanism is unclear. The present study was designed to investigate the relationship between the CNS damage and cognitive dysfunction caused by CS2, and eventually reveal the possible oxidative-related mechanism of hippocampus pathological changes in CS2 exposed rats. Male Wistar rats were administrated with CS2 at dosage of 200, 400 and 600 mg/kg for consecutive 20 days, respectively. Cognitive performances were evaluated by Morris water maze tests...
November 29, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27899116/the-correlation-between-antimutagenic-activity-and-total-phenolic-content-of-extracts-of-31-plant-species-with-high-antioxidant-activity
#6
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Antimutagenic activity of plant extracts is important in the discovery of new, effective cancer preventing agents. There is increasing evidence that cancer and other mutation-related diseases can be prevented by intake of DNA protective agents. The identification of antimutagenic agents present in plants presents an effective strategy to inhibit pathogenic processes resulting from exposure to mutagenic and/or carcinogenic substances present in the environment. There are no reports on the antimutagenic activities of the plant species investigated in this study...
November 29, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27899008/jordanian-nursing-work-environments-intent-to-stay-and-job-satisfaction
#7
Zaid Al-Hamdan, Milisa Manojlovich, Banerjee Tanima
PURPOSE: The purpose of this study was to examine associations among the nursing work environment, nurse job satisfaction, and intent to stay for nurses who practice in hospitals in Jordan. DESIGN: A quantitative descriptive cross-sectional survey design was used. METHODS: Data were collected through survey questionnaires distributed to 650 registered nurses (RNs) who worked in three hospitals in Jordan. The self-report questionnaire consisted of three instruments and demographic questions...
November 4, 2016: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/27895655/protein-tyrosine-nitration-during-development-and-abiotic-stress-response-in-plants
#8
REVIEW
Capilla Mata-Pérez, Juan C Begara-Morales, Mounira Chaki, Beatriz Sánchez-Calvo, Raquel Valderrama, María N Padilla, Francisco J Corpas, Juan B Barroso
In recent years, the study of nitric oxide (NO) in plant systems has attracted the attention of many researchers. A growing number of investigations have shown the significance of NO as a signal molecule or as a molecule involved in the response against (a)biotic processes. NO can be responsible of the post-translational modifications (NO-PTM) of target proteins by mechanisms such as the nitration of tyrosine residues. The study of protein tyrosine nitration during development and under biotic and adverse environmental conditions has increased in the last decade; nevertheless, there is also an endogenous nitration which seems to have regulatory functions...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27893919/health-literacy-competencies-for-registered-nurses-an-e-delphi-study
#9
Coleen E Toronto
BACKGROUND: The Institute of Medicine's landmark report, Health Literacy: A Prescription to End Confusion, recommends that health professionals be trained to effectively communicate with patients with limited health literacy. Nurse-specific competencies that explicitly address the needs of patients with low health literacy are lacking. METHOD: A national group of nurse health literacy experts (N = 41) participated in a three-round e-Delphi study to identify essential health literacy competencies for RNs in any work setting...
December 1, 2016: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/27893496/do-leadership-style-unit-climate-and-safety-climate-contribute-to-safe-medication-practices
#10
Amany Farag, Susan Tullai-McGuinness, Mary K Anthony, Christopher Burant
OBJECTIVES: This study aims at: examining if leadership style and unit climate predict safety climate; and testing the direct, indirect, and total effect of leadership style, unit climate, and safety climate on nurses' safe medication practices. BACKGROUND: The Institute of Medicine and nursing scholars propose that safety climate is a prerequisite to safety practices. However, there is limited empirical evidence about factors contributing to the development of safety climate and about the association with nurses' safe medication practices...
November 23, 2016: Journal of Nursing Administration
https://www.readbyqxmd.com/read/27890063/guideline-implementation-patient-information-management
#11
Jennifer L Fencl
Clinical documentation captured in a patient's record provides health care personnel with information that can be used to guide patient care. Data collected in electronic health records can be accessed and aggregated across the health care delivery system to enhance the safety, quality, and efficacy of care. The updated AORN "Guideline for patient information management" provides guidance to perioperative personnel on documenting and managing patient information. This article focuses on key points of the guideline, which address data capture that supports the clinical workflow, incorporation of professional guidelines and standards as well as regulatory and mandatory reporting elements, use of standardized clinical terminologies, data aggregation for use in research and analytics, considerations for patient care orders, and safeguards for the patient's security and confidentiality...
December 2016: AORN Journal
https://www.readbyqxmd.com/read/27888966/implementation-of-a-recovery-oriented-training-program-for-psychiatric-nurses-in-the-inpatient-setting-a-mixed-methods-hospital-quality-improvement-study
#12
Renee John R Repique, Peter M Vernig, John Lowe, Julie A Thompson, Tracey L Yap
This mixed-methods hospital quality improvement (QI) study primarily aimed to reduce the use of mechanical restraints in a short-stay inpatient psychiatric setting by facilitating change in care delivery through recovery-oriented nursing practice. The implementation of an evidence-based education for psychiatric-mental health registered nurses (PMH-RNs) intended to improve their knowledge of, and attitudes toward, recovery-focused mental health treatment principles. Findings suggest that recovery-oriented training programs for PMH-RNs can be a potentially useful hospital strategy for restraint reduction...
December 2016: Archives of Psychiatric Nursing
https://www.readbyqxmd.com/read/27888001/antioxidants-and-hne-in-redox-homeostasis
#13
REVIEW
Wojciech Łuczaj, Agnieszka Gęgotek, Elżbieta Skrzydlewska
Under physiological conditions, cells are in a stable state known as redox homeostasis, which is maintained by the balance between continuous ROS/RNS generation and several mechanisms involved in antioxidant activity. ROS overproduction results in alterations in the redox homeostasis that promote oxidative damage to major components of the cell, including the biomembrane phospholipids. Lipid peroxidation subsequently generates a diverse set of products, including α,β-unsaturated aldehydes. Of these products, 4-hydroxy-2-nonenal (HNE) is the most studied aldehyde on the basis of its involvement in cellular physiology and pathology...
November 22, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27885867/protein-corona-modulation-of-hepatocyte-uptake-and-molecular-mechanisms-of-gold-nanoparticle-toxicity
#14
Kyoungju Choi, Jim E Riviere, Nancy A Monteiro-Riviere
Protein corona formation over gold nanoparticles (AuNP) can modulate cellular responses by altering AuNP physicochemical properties. The liver plays an essential role in metabolism, detoxification and elimination of xenobiotics and drugs as well as circulating NP clearance. We investigated human hepatic uptake of 40 and 80nm AuNP with branched polyethylenimine (BPEI), lipoic acid (LA) and polyethylene glycol (PEG) coatings as well as human plasma protein (HP) and human serum albumin (HSA) coronas. AuNP-mediated cytotoxicity, reactive oxygen/reactive nitrogen species (ROS/RNS), and CYP activity in human hepatocytes as well as molecular mechanisms with 40nm bare and HP BPEI-AuNP were investigated...
November 25, 2016: Nanotoxicology
https://www.readbyqxmd.com/read/27879983/delirium-a-survey-of-healthcare-professionals-knowledge-beliefs-and-practices
#15
Liron Sinvani, Andrzej Kozikowski, Renee Pekmezaris, Meredith Akerman, Gisele Wolf-Klein
OBJECTIVES: To evaluate knowledge, beliefs, and practices regarding delirium of physicians, nurse practitioners (NPs), and registered nurses (RNs). DESIGN: Anonymous cross-sectional paper survey. SETTING: New York metropolitan area tertiary care hospital. PARTICIPANTS: RNs, NPs, and physicians (N = 164). MEASUREMENTS: The survey assessed knowledge, beliefs, and practices regarding delirium and prior delirium or geriatric training...
November 23, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27875451/developing-a-framework-to-help-bedside-nurses-bring-about-change
#16
Jordan S Porter, Kelley A Strout
: Nurses across all care settings and experience levels are being called upon to lead. In a 2011 report, The Future of Nursing: Leading Change, Advancing Health, the Institute of Medicine examined the ways nurses could more fully apply their knowledge of direct patient care to address the increasing demands placed on the health care system since the passage of the Affordable Care Act. The report asked: "What roles can nursing assume to address the increasing demand for safe, high-quality, and effective health care services?"Multiple variables influence a nurse's ability to assume a leadership role, and multiple barriers to these roles continue to exist...
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27867187/crosstalk-of-ros-rns-and-autophagy-in-silibinin-induced-apoptosis-of-mcf-7-human-breast-cancer-cells-in-vitro
#17
Nan Zheng, Lu Liu, Wei-Wei Liu, Fei Li, Toshihiko Hayashi, Shin-Ichi Tashiro, Satoshi Onodera, Takashi Ikejima
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles in regulating cell survival and death. Silibinin is a natural polyphenolic flavonoid isolated from milk thistle with anti-tumor activities, but it was found to induce cytoprotective ROS/RNS in human breast cancer MCF-7 cells. Furthermore, treatment with silibinin down-regulates ERα expression in MCF-7 cells, and inducing both autophagy and apoptosis. In this study we explored the relationship between ER-associated pathways and RNS/ROS in MCF-7 cells...
November 21, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27865000/improving-the-quality-of-registered-nurses-rns-working-time-use-data
#18
Tuula Antinaho, Tuula Kivinen, Hannele Turunen, Pirjo Partanen
AIMS AND OBJECTIVES: The aim of this study was to examine the advantages and disadvantages of external observation and self-reporting methods in investigating registered nurses' (RNs') working time use in order to improve the quality of working time use data. BACKGROUND: External observation and self-reporting methods are the most widely used approaches for studying nurses' working time use in observational work sampling studies, but there is scarce information of the data collection procedures and results in the same research context and in the same study...
November 16, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27864827/biomarkers-of-oxidative-and-nitro-oxidative-stress-conventional-and-novel-approaches
#19
REVIEW
Ana Cipak Gasparovic, Neven Zarkovic, Kamelija Zarkovic, Khrystyna Semen, Danylo Kaminskyy, Olha Yelisyeyeva, Serge P Bottari
The concept of oxidative stress (OS) which associates altered redox biology with various diseases was introduced thirty years ago and has generated intensive research over the past two decades. Whereas it is now commonly accepted that macromolecule oxidation in response to reactive oxygen species (ROS) is associated with a variety of pathologies, the emergence of NO as a key regulator of redox signalling has led to the discovery of the pathophysiological significance of reactive nitrogen species (RNS). RNS can elicit various modifications of macromolecules and lead to nitrative or nitro-OS...
November 19, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27863045/substituent-effects-in-bodipy-in-live-cell-imaging
#20
Sandip V Mulay, Tesla Yudhistira, Minsuk Choi, Youngsam Kim, Jinjoo Kim, Yoon Jeong Jang, Sangyong Jon, David G Churchill
Small molecule organoselenium-based fluorescent probes possess great capacity in understanding biological processes through detection of various analytes such as reactive oxygen/nitrogen species (ROS/RNS), biothiols (cysteine, homocysteine, and glutathione), and lipid droplets etc. Herein, we present how substituents in the BODIPY system play a significant part in the detection of biological important analytes for in vitro conditions and live cell imaging studies. The fluorescence of the probe was quenched by 2-chloro and 6-phenyl selenium groups; the probe shows high selectivity with NaOCl among other ROS/RNS, and gives a turn-on response...
November 11, 2016: Chemistry, An Asian Journal
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