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https://www.readbyqxmd.com/read/29138593/intrathecal-pain-management-a-team-based-approach
#1
REVIEW
Jeremy A Adler, Neona M Lotz
Objective: Physician assistants (PAs), nurse practitioners (NPs), and registered nurses (RNs) provide professional services on pain management teams. This review provides an overview of the practical management of chronic pain with intrathecal (IT) therapy using an interprofessional approach (eg, physicians and other health care professionals), with a focus on the contributions of PAs, NPs, and RNs. Methods: Narrative review based on literature searches of the Medline database and treatment guidelines on the use of IT therapy in the management of patients with chronic pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29137940/autoamplificatory-singlet-oxygen-generation-sensitizes-tumor-cells-for-intercellular-apoptosis-inducing-signaling
#2
Georg Bauer
Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. TREATMENT: of tumor cells with high concentrations of H2O2, peroxnitrite, HOCl, or increasing the concentration of cell-derived NO causes initial generation of singlet oxygen and local inactivation of membrane-associated catalase. As a result, free peroxynitrite and H2O2 interact and generate secondary singlet oxygen...
November 11, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29123138/chemical-and-cellular-oxidant-production-induced-by-naphthalene-secondary-organic-aerosol-soa-effect-of-redox-active-metals-and-photochemical-aging
#3
Wing Y Tuet, Yunle Chen, Shierly Fok, Dong Gao, Rodney J Weber, Julie A Champion, Nga L Ng
Exposure to air pollution is a leading global health risk. Secondary organic aerosol (SOA) constitute a large portion of ambient particulate matter (PM). In this study, the water-soluble oxidative potential (OP) determined by dithiothreitol (DTT) consumption and intracellular reactive oxygen and nitrogen species (ROS/RNS) production was measured for SOA generated from the photooxidation of naphthalene in the presence of iron sulfate and ammonium sulfate seed particles. The measured intrinsic OP varied for aerosol formed using different initial naphthalene concentrations, however, no trends were observed between OP and bulk aerosol composition or seed type...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29118452/magnesium-homeostasis-protects-salmonella-against-nitrooxidative-stress
#4
Travis J Bourret, Lin Liu, Jeff A Shaw, Maroof Husain, Andrés Vázquez-Torres
The PhoPQ two-component regulatory system coordinates the response of Salmonella enterica serovar Typhimurium to diverse environmental challenges encountered during infection of hosts, including changes in Mg(2+) concentrations, pH, and antimicrobial peptides. Moreover, PhoPQ-dependent regulation of gene expression promotes intracellular survival of Salmonella in macrophages, and contributes to the resistance of this pathogen to reactive nitrogen species (RNS) generated from the nitric oxide produced by the inducible nitric oxide (NO) synthase of macrophages...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117451/factors-predicting-registered-nurses-intentions-to-leave-their-organisation-and-profession-a-job-demands-resources-framework
#5
Willoughby Moloney, Peter Boxall, Matthew Parsons, Gordon Cheung
AIMS: To develop a comprehensive model of nursing turnover intention by examining the effects of job demands, job resources, personal demands and personal resources on burnout and work engagement and subsequently on the intention to leave the organisation and profession. BACKGROUND: The ageing population and a growing prevalence of multimorbidity are placing increasing strain on an ageing nursing workforce. Solutions that address the anticipated nursing shortage should focus on reducing burnout and enhancing the engagement of Registered Nurses (RNs) to improve retention...
November 8, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29117446/challenging-rules-creating-values-park-s-sweet-spot-theory-driven-central-optimum-nurse-staffing-zone
#6
EDITORIAL
Claire Su-Yeon Park
The nursing shortage is a serious global issue. Low birth rates and a rapidly aging population are accelerating the demands of nursing professionals. However, the challenging aspects of nurses' work environment-e.g., a poor salary, long shift length, heavy workload, temporary staffing, or bullying-are still ongoing, leading to compromised patient care, more care left undone, adverse events, poor care quality, inequity in access to healthcare, longer waiting times, burnout and illness among nurses, and even unexpected yet preventable patient deaths (Ball et al...
November 8, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29117055/improving-patient-experience-through-nursing-satisfaction
#7
Amanda McNicholas, Abby McCall, Alanna Werner, Ronda Wounderly, Erin Marinchak, Pamela Jones
Patient experience is a vital component of quality health care. In our institution we sought to improve both nursing satisfaction and collaboration, in conjunction with improving patient experience, predicting the two are directly proportional. We hypothesized that a more satisfied nursing team would result in an overall improvement in patient experience. To explore this hypothesis, we implemented multiple process changes to create an advanced practitioner-directed floor (APDF) on our 28-bed trauma, medical-surgical unit...
November 2017: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
https://www.readbyqxmd.com/read/29116683/nursing-gender-pay-differentials-in-the-new-millennium
#8
Barbara L Wilson, Matthew J Butler, Richard J Butler, William G Johnson
BACKGROUND: The gender pay gap in the United States is an ongoing issue, affecting women in nearly all occupations. Jobs traditionally associated with men tend to pay better than traditionally female-dominated jobs, and there is evidence to suggest within-occupation gender pay differences as well. PURPOSE: We compared and contrasted gender wage disparities for registered nurses (RNs), relative to gender wage disparities for another female-dominated occupation, teachers, while controlling for sociodemographic factors...
November 8, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/29115748/an-integrative-review-of-absenteeism-in-newly-graduated-nurses
#9
Judy Craft, Martin Christensen, Lisa Wirihana, Shannon Bakon, Jennie Barr, Lily Tsai
Managing sickness and absenteeism in the workplace is challenging, and nurse managers must consider their various causes so they can implement effective management strategies. It is also vital to consider the factors that influence absenteeism and turnover among newly graduated registered nurses (RNs), whose retention can help to address staff shortages. This article describes a literature review that aimed to identify the potential causes of sickness absence in newly graduated RNs. It also discusses strategies that nurse managers can use to retain and maintain their workforce...
October 30, 2017: Nursing Management (Harrow)
https://www.readbyqxmd.com/read/29114232/re-evaluation-of-imaging-methods-of-reactive-oxygen-and-nitrogen-species-in-plants-and-fungi-influence-of-cell-wall-composition
#10
REVIEW
Michaela Sedlářová, Lenka Luhová
Developmental transitions and stress reactions in both eukaryotes and prokaryotes are tightly linked with fast and localized modifications in concentrations of reactive oxygen and nitrogen species (ROS and RNS). Fluorescent microscopic analyses are widely applied to detect localized production of ROS and RNS in vivo. In this mini-review we discuss the biological characteristics of studied material (cell wall, extracellular matrix, and tissue complexity) and its handling (concentration of probes, effect of pressure, and higher temperature) which influence results of histochemical staining with "classical" fluorochromes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29112580/the-role-of-the-registered-nurse-in-the-insertion-of-nontunneled-central-vascular-access-devices
#11
Ann Plohal, Cheryl Dumont, Cathy Perry, Velda Biddix, Diedre B Bird, Teresa Darst, Candee J Eisenhart, Melanie Pugh
As the result of requests from several state boards of nursing, the Infusion Nurses Society (INS) convened a task force to determine whether insertion of central vascular access devices by appropriately trained registered nurses (RNs) should be recommended. The task force consisted of RNs and advanced practice registered nurses with infusion therapy experience in various practice settings. The results are presented in INS' newest position paper, adopted by the INS Board of Directors, September 2017.
November 2017: Journal of Infusion Nursing: the Official Publication of the Infusion Nurses Society
https://www.readbyqxmd.com/read/29108086/anti-degenerative-effect-of-apigenin-luteolin-and-quercetin-on-human-keratinocyte-and-chondrocyte-cultures-sar-evaluation
#12
Lucia Crascì, Venera Cardile, Giusy Longhitano, Francesco Nanfitò, Annamaria Panico
Background Inflammation is a dynamic process that occur on vascularized tissue in response to different stimuli causing cell injury and tissue degeneration. Reactive oxygen and nitrogen species (ROS and RNS) and advanced glycation end products (AGEs) have a key mediatory role in the development and progression of degenerative tissue process. The bioflavonoids possess a broad-spectrum of pharmacological activities. Their capability is related to their chemical structure. Methods In this study we evaluated and compare antioxidant, anti-glycative and anti-degenerative actions of two flavones apigenin and luteolin and a flavonol quercetin, in function of their hydroxyl groups arrangement...
November 6, 2017: Drug Research
https://www.readbyqxmd.com/read/29107263/clinical-issues-november-2017
#13
Esther M Johnstone
Heating, ventilation, and air-conditioning (HVAC) systems in the OR Key words: airborne contaminants, HVAC system, air pressure, air quality, temperature and humidity. Air changes and positive pressure Key words: air changes, positive pressure airflow, unidirectional airflow, outdoor air, recirculated air. Product selection Key word: product evaluation, product selection, selection committee. Entry into practice Key words: associate degree in nursing, bachelor of science in nursing, entry-level position, advanced education, BSN-prepared RNs...
November 2017: AORN Journal
https://www.readbyqxmd.com/read/29107257/translating-evidence-into-practice-how-advanced-practice-rns-can-guide-nurses-in-challenging-established-practice-to-arrive-at-best%C3%A2-practice
#14
Jennifer L Fencl, Candace Matthews
Nursing is an information-intensive profession, requiring nurses to have high information literacy and the skills to find, understand, evaluate, and use information from a multitude of sources. The advanced practice RN (APRN) is a valuable resource to support and guide nurses in this effort. The APRN's skills encompass understanding and implementing evidence-based practice, evaluating the organizational structure (eg, units, facilities, multisystem organizations) across the continuum of care, and facilitating collaboration between perioperative nurses and other interprofessional team members to sustain practice changes in the clinical setting...
November 2017: AORN Journal
https://www.readbyqxmd.com/read/29104732/the-role-of-nrf2-in-cardiovascular-function-and-disease
#15
REVIEW
Sandro Satta, Ayman M Mahmoud, Fiona L Wilkinson, M Yvonne Alexander, Stephen J White
Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and hydrogen peroxide play an important role in both intracellular and intercellular signaling; however, their production and quenching need to be closely regulated to prevent cellular damage. An imbalance, due to exogenous sources of free radicals and chronic upregulation of endogenous production, contributes to many pathological conditions including cardiovascular disease and also more general processes involved in aging. Nuclear factor erythroid 2-like 2 (NFE2L2; commonly known as Nrf2) is a transcription factor that plays a major role in the dynamic regulation of a network of antioxidant and cytoprotective genes, through binding to and activating expression of promoters containing the antioxidant response element (ARE)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29091732/a-six-coordinate-peroxynitrite-low-spin-iron-iii-porphyrinate-complex-the-product-of-the-reaction-of-nitrogen-monoxide-%C3%A2-no-g-with-a-ferric-superoxide-species
#16
Savita K Sharma, Andrew W Schaefer, Hyeongtaek Lim, Hirotoshi Matsumura, Pierre Moënne-Loccoz, Britt Hedman, Keith O Hodgson, Edward I Solomon, Kenneth D Karlin
Peroxynitrite (-OON=O, PN) is a reactive nitrogen species (RNS) which can effect deleterious nitrative or oxidative (bio)chemistry. It may derive from reaction of superoxide anion (O2•-) with nitric oxide (•NO) and has been suggested to form an as-yet unobserved bound heme-iron-PN intermediate in the catalytic cycle of Nitric Oxide Dioxygenase (NOD) enzymes, which facilitate a •NO homeostatic process, i.e., its oxidation to the nitrate anion. Here, a discrete six-coordinate low-spin porphyrinate-FeIII complex [(PIm)FeIII(-OON=O)] (3) (PIm; a porphyrin moiety with a covalently tethered imidazole axial 'base' donor ligand) has been identified and characterized by various spectroscopies (UV-Vis, NMR, EPR, XAS, resonance Raman) and DFT calculations, following its formation at -80 °C by addition of •NO(g) to the heme-superoxo species, [(PIm)FeIII(O2•-)] (2)...
November 1, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29091239/effects-of-didactic-instruction-and-test-enhanced-learning-in-a-nursing-review-course
#17
Yu-Ching Tu, Yi-Jung Lin, Jonathan W Lee, Lir-Wan Fan
BACKGROUND: Determining the most effective approach for students' successful academic performance and achievement on the national licensure examination for RNs is important to nursing education and practice. METHOD: A quasi-experimental design was used to compare didactic instruction and test-enhanced learning among nursing students divided into two fundamental nursing review courses in their final semester. Students in each course were subdivided into low-, intermediate-, and high-score groups based on their first examination scores...
November 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/29091236/demographic-and-academic-factors-associated-with-enrollment-in-online-msn-programs
#18
Daisha J Cipher, Sachin Shrestha, Mary E Mancini
BACKGROUND: There is a need to better understand the demographic and academic characteristics of individuals enrolled in online Master of Science in Nursing (MSN) programs. METHOD: This article reports a retrospective analysis of 4,079 students enrolled in one of three MSN programs: family nurse practitioner (FNP), nurse educator, and nursing administration. Demographic characteristics (i.e., gender, race, age) and academic variables (i.e., academic load, past undergraduate/graduate enrollment at the university) were examined for all enrollees...
November 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/29083458/key-elements-to-developing-a-preceptor-program
#19
Denise Duffy Nash, Monica Flowers
BACKGROUND: With competition from so many nursing programs seeking clinical sites and numerous nurses entering the health care industry, it is imperative to have a nurse preceptor program in health care institutions. METHOD: This article attempts to identify the essential components of a preceptor program by reviewing the literature, surveying RNs to identify curriculum, and suggesting an evidence-based preceptor program of value. RESULTS: Although there is much in the published literature and books about preceptors' roles and responsibilities, few references are available about how to start a preceptor program and program components...
November 1, 2017: Journal of Continuing Education in Nursing
https://www.readbyqxmd.com/read/29076262/registered-nurses-own-experience-of-using-a-nurse-initiated-pain-protocol-based-on-their-working-experience
#20
L Sturesson, A-C Falk, J Ulfvarson, V Lindström
AIMS & OBJECTIVES: The aim of the study was to explore registered nurses' (RN) own experience of using the nurse-initiated pain protocol (NIPP) in the emergency department (ED) based on their working experience. BACKGROUND: Pain is known to be one of the most common symptoms among adult patients seeking care at the ED. Several strategies aiming to improve pain management have been developed. Despite some improvements in pain management by using NIPP, a large number of patients continue to have inadequate pain treatment when cared for in EDs...
October 27, 2017: Journal of Clinical Nursing
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