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https://www.readbyqxmd.com/read/28632245/development-of-an-instrument-to-examine-nursing-attitudes-toward-fertility-preservation-in-oncology
#1
Maria C Grabowski, Deborah A Spitzer, Sonja E Stutzman, DaiWai M Olson
PURPOSE/OBJECTIVES: To develop an instrument to measure staff nurse perceptions of the barriers to and benefits of addressing fertility preservation (FP) with patients newly diagnosed with cancer. 
. DESIGN: A prospective, nonrandomized instrument development approach. 
. SETTING: Harold C. Simmons Comprehensive Cancer Center at the University of Texas Southwestern Medical Center in Dallas. 
. SAMPLE: 224 RNs who care for patients with cancer...
July 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28630313/targeting-reactive-nitrogen-species-suppresses-hereditary-pancreatic-cancer
#2
Mo Li, Qian Chen, Teng Ma, Xiaochun Yu
Germline mutation of BRCA2 induces hereditary pancreatic cancer. However, how BRCA2 mutation specifically induces pancreatic tumorigenesis remains elusive. Here, we have examined a mouse model of Brca2-deficiency-induced pancreatic tumors and found that excessive reactive nitrogen species (RNS), such as nitrite, are generated in precancerous pancreases, which induce massive DNA damage, including DNA double-strand breaks. RNS-induced DNA lesions cause genomic instability in the absence of Brca2. Moreover, with the treatment of antioxidant tempol to suppress RNS, not only are DNA lesions significantly reduced, but also the onset of pancreatic cancer is delayed...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28629723/microbial-antioxidant-defense-enzymes
#3
REVIEW
Cindy Staerck, Amandine Gastebois, Patrick Vandeputte, Alphonse Calenda, Gérald Larcher, Louiza Gillmann, Nicolas Papon, Jean-Philippe Bouchara, Maxime J J Fleury
Free radicals are often described as chemical compounds characterized by unpaired electrons in their outer orbital rendering them highly reactive species. In mammalians, studies on free radicals were focused on reactive oxygen species (ROS) or reactive nitrogen species (RNS) due to their relative importance in physiological as well as in pathological processes. These cellular compounds are produced by different physiological systems such as the aerobic metabolism and play a major role in cell signaling pathways but also in the host immune defenses against pathogenic microorganisms...
June 16, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28628524/experiences-of-non-specialist-nurses-caring-for-patients-and-their-significant-others-undergoing-transitions-during-palliative-end-of-life-cancer-care-a-systematic-review
#4
Hrønn Thorn, Lisbeth Uhrenfeldt
BACKGROUND: Non-specialist nurses, who are providing palliative end-of-life cancer care to patients and significant others undergoing psychosocial and existential transitions, may experience dissatisfaction, frustration and sorrow. On the other hand, they may also experience happiness, increased knowledge and personal growth. OBJECTIVE/QUESTION: What are non-specialist nurses' experiences when providing palliative end-of-life cancer care that involves the psychosocial and existential transitions of their patients and significant others? INCLUSION CRITERIA TYPES OF PARTICIPANTS: The current review considered studies that included a description of the experiences of non-specialist trained registered nurses (RNs) working in non-specialist wards...
June 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28622140/reactive-nitrogen-species-rns-resistant-microbes-adaptation-and-medical-implications
#5
Sujeenthar Tharmalingam, Azhar Alhasawi, Varun P Appanna, Joe Lemire, Vasu D Appanna
Nitrosative stress results from an increase in reactive nitrogen species (RNS) within the cell. Though the RNS - nitric oxide (NO) and peroxynitrite (ONOO-) - play pivotal physiological roles, at elevated concentrations, these moieties can be poisonous to both prokaryotic and eukaryotic cells alike due to their capacity to disrupt a variety of essential biological processes. Numerous microbes are known to adapt to nitrosative stress by elaborating intricate strategies aimed at neutralizing RNS. In this review, we will discuss both the enzymatic systems dedicated to the elimination of RNS as well as the metabolic networks that are tailored to generate RNS-detoxifying metabolites - α-keto-acids...
June 15, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28620142/magnetic-resonance-imaging-of-rrx-001-pharmacodynamics-in-preclinical-tumors
#6
Natarajan Raghunand, Jan Scicinski, Gerald P Guntle, Bhumasamudram Jagadish, Eugene A Mash, Elizabeth Bruckheimer, Bryan Oronsky, Ronald L Korn
RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing's Sarcoma, HT-29 colorectal carcinoma, and PANC-1 pancreatic carcinoma xenografts in SCID mice. Binding of Gd-LC7-SH to the Cys34 residue on plasma albumin prolongs retention in the tumor microenvironment and increases tumor enhancement on MRI. Mice were imaged by MRI and in vivo T1 maps acquired 50 min (T150 min) after injection of 0...
June 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28613231/melatonin-scavenger-properties-against-oxidative-and-nitrosative-stress-impact-on-gamete-handling-and-in-vitro-embryo-production-in-humans-and-other-mammals
#7
REVIEW
Pía Loren, Raúl Sánchez, María-Elena Arias, Ricardo Felmer, Jennie Risopatrón, Carolina Cheuquemán
Oxidative and nitrosative stress are common problems when handling gametes in vitro. In vitro development in mammalian embryos is highly affected by culture conditions, especially by reactive oxygen species (ROS) and reactive nitrogen species (RNS), because their absence or overproduction causes embryo arrest and changes in gene expression. Melatonin in gamete co-incubation during in vitro fertilization (IVF) has deleterious or positive effects, depending on the concentration used in the culture medium, demonstrating the delicate balance between antioxidant and pro-oxidant activity...
June 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28604507/visits-to-registered-nurses-an-opportunity-to-increase-contraceptive-access-in-california
#8
Emese C Parker, Kevin Kong, Leslie A Watts, Eleanor B Schwarz, Philip D Darney, Heike Thiel de Bocanegra
BACKGROUND: In 2013, California passed Assembly Bill (A.B.) 2348, approving registered nurses (RNs) to dispense patient self-administered hormonal contraceptives and administer injections of hormonal contraceptives. The Family Planning, Access, Care and Treatment (Family PACT) program, which came into effect in 1997 to expand low-income, uninsured California resident access to contraceptives at no cost, is one program in which qualified RNs can dispense and administer contraceptives. AIMS: The aims of this study were to (a) describe utilization of RN visits within California's Family PACT program and (b) evaluate the impact of RN visits on client birth control acquisition during the first 18 months after implementation of A...
June 10, 2017: Nursing Research
https://www.readbyqxmd.com/read/28596679/oxidative-stress-induced-mitochondrial-dysfunction-in-a-normal-colon-epithelial-cell-line
#9
Nandakumar Packiriswamy, Kari F Coulson, Susan J Holcombe, Lorraine M Sordillo
AIM: To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease. METHODS: Normal human colon epithelial cells (ATCC(®) CRL.1790™) were stimulated with either heat killed E. coli or heat killed murine cecal contents (HKC) and examined for several relevant biomarkers associated with inflammation and oxidative stress including cytokine production, mitochondrial autophagy and oxidant status...
May 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28596380/identification-of-oxidative-modifications-of-hemopexin-and-their-predicted-physiological-relevance
#10
Peter Hahl, Rachel Hunt, Edward S Bjes, Andrew Skaff, J Andrew Keightley, Ann Smith
Hemopexin protects against heme toxicity in hemolytic diseases and conditions, sepsis and sickle cell disease. This protection is sustained by heme-hemopexin complexes present in biological fluids that resist oxidative damage during heme-driven inflammation. However, apo-hemopexin is vulnerable to inactivation by reactive nitrogen and oxygen species that covalently modify amino acids. The consequent nitration of amino acids is considered a selective and specific effect reflecting biological events. Using liquid chromatography-tandem mass spectrometry, we discovered low endogenous levels of tyrosine nitration in the peptide YYCFQGNQFLR of human hemopexin, which was similarly nitrated in rabbit and rat hemopexins...
June 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28595110/utilization-of-registered-nurses-in-primary-care-teams-a-systematic-review
#11
REVIEW
Allison Norful, Grant Martsolf, Krystyna de Jacq, Lusine Poghosyan
BACKGROUND: Registered nurses are increasingly becoming embedded in primary care teams yet there is a wide variability in nursing roles and responsibilities across organizations. Policy makers are calling for a closer look at how to best utilize registered nurses in primary care teams. Lack of knowledge about effective primary care nursing roles and responsibilities challenges policy makers' abilities to develop recommendations to effectively deploy registered nurses in primary care needed to assure efficient, evidence-based, and quality health care...
May 20, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28592749/dynamics-of-oxidative-stress-evoked-by-myocardial-ischemia-reperfusion-after-off-pump-coronary-artery-bypass-grafting-elucidated-by-bilirubin-oxidation
#12
Masaki Yamamoto, Hideaki Nishimori, Takashi Fukutomi, Tokio Yamaguchi, Kazumasa Orihashi
BACKGROUND: Revascularization therapy relieves myocardial ischemia, but can also result in ischemia-reperfusion injury caused by oxidative stress. However, the biokinetics of oxidative stress after myocardial ischemia-reperfusion are uncertain. This study aimed to evaluate the dynamics of oxidative stress after off-pump coronary artery bypass grafting (OPCAB) by measuring urinary biopyrrin levels. Biopyrrin is an oxidative metabolite of bilirubin thought to reflect oxidative stress, along with reactive nitrogen species (RNS)...
June 8, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28591677/a-highly-sensitive-and-selective-fluorimetric-probe-for-intracellular-peroxynitrite-based-on-photoinduced-electron-transfer-from-ferrocene-to-carbon-dots
#13
Jiali Zhu, Shan Sun, Kai Jiang, Yuhui Wang, Wenqing Liu, Hengwei Lin
Herein, a highly sensitive and selective fluorimetric nanoprobe for peroxynitrite (ONOO(-)) detection based on photoinduced electron transfer (PET) from ferrocene (Fc) to carbon dots (CDs) is reported. The nanoprobe (named CDs-Fc) can be facilely constructed through covalently conjugating CDs and ferrocenecarboxylic acid. Further studies reveal that the energy level of highest occupied molecular orbital (HOMO) of the CDs is lowered with the addition of ONOO(-) due to its oxidation and nitration capabilities...
May 31, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28591612/role-of-ambient-gas-composition-on-cold-physical-plasma-elicited-cell-signaling-in-keratinocytes
#14
Anke Schmidt, Sander Bekeschus, Helena Jablonowski, Annemarie Barton, Klaus-Dieter Weltmann, Kristian Wende
A particularly promising medical application of cold physical plasma is the support of wound healing. This is presumably achieved by modulating inflammation as well as skin cell signaling and migration. Plasma-derived reactive oxygen and nitrogen species (ROS/RNS) are assumed the central biologically active plasma components. We hypothesized that modulating the environmental plasma conditions from pure nitrogen (N2) to pure oxygen (O2) in an atmospheric pressure argon plasma jet (kINPen) will change type and concentration of ROS/RNS and effectively tune the behavior of human skin cells...
June 6, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28585985/investigating-interrater-reliability-in-an-online-rn-to-bsn-program-disparate-conclusions
#15
Jill F Kilanowski, Miriam Bowers Abbott
BACKGROUND: Interrater reliability of student-written assignments within a nursing education program is a desirable characteristic to ensure uniform quality of academic work. As online programs that advance RNs to baccalaureate-prepared nurses (i.e., RN-to-BSN programs) grow in popularity, the challenges of quality control increase. METHOD: Grading data representing mean, median, mode, and range from 19 course sections in an online RN-to-BSN program were submitted...
June 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28578514/the-beneficial-effects-of-hmg-coa-reductase-inhibitors-in-the-processes-of-neurodegeneration
#16
REVIEW
Seyed Soheil Saeedi Saravi, Seyed Sobhan Saeedi Saravi, Alireza Arefidoust, Ahmad Reza Dehpour
Statins, cholesterol lowering drugs, have been demonstrated to exert beneficial effects in other conditions such as primary and progressing neurodegenerative diseases beyond their original role. Observation that statins ameliorate the neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS) and cerebral ischemic stroke, the neuroprotective effects of these drugs are thought to be linked to their anti-inflammatory, anti-oxidative, and anti-excitotoxic properties...
June 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28571751/plasma-induced-selectivity-in-bone-cancer-cells-death
#17
Cristina Canal, Raul Fontelo, Ines Hamouda, Jordi Guillem-Marti, Uros Cvelbar, Maria-Pau Ginebra
BACKGROUND: Current therapies for bone cancers - either primary or metastatic - are difficult to implement and unfortunately not completely effective. An alternative therapy could be found in cold plasmas generated at atmospheric pressure which have already demonstrated selective anti-tumor action in a number of carcinomas and in more relatively rare brain tumors. However, its effects on bone cancer are still unknown. METHODS: Herein, we employed an atmospheric pressure plasma jet (APPJ) to validate its selectivity towards osteosarcoma cell line vs...
May 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28570379/promoting-evidence-based-practice-at-a-primary-stroke-center-a-nurse-education-strategy
#18
Christina Anne Case
BACKGROUND: Promoting a culture of evidence-based practice within a health care facility is a priority for health care leaders and nursing professionals; however, tangible methods to promote translation of evidence to bedside practice are lacking. OBJECTIVES: The purpose of this quality improvement project was to design and implement a nursing education intervention demonstrating to the bedside nurse how current evidence-based guidelines are used when creating standardized stroke order sets at a primary stroke center, thereby increasing confidence in the use of standardized order sets at the point of care and supporting evidence-based culture within the health care facility...
July 2017: Dimensions of Critical Care Nursing: DCCN
https://www.readbyqxmd.com/read/28556871/nursing-work-in-long-term-care-an-integrative-review
#19
Jed Montayre, Jasmine Montayre
Evidence suggests that delivery of good nursing care in long-term care (LTC) facilities is reflected in nurses' descriptions of the factors and structures that affect their work. Understanding the contemporary nature of nursing work in aged care will influence policies for improving current work structures in this practice setting. The current review aims to present a contemporary perspective of RNs' work in LTC facilities. A comprehensive search and purposeful selection of the literature was conducted using CINAHL, PubMed, Medline, Scopus, and Google Scholar databases...
May 30, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/28554165/network-modeling-of-resting-state-connectivity-points-towards-the-bottom-up-theories-of-schizophrenia
#20
François Orliac, Pascal Delamillieure, Nicolas Delcroix, Mikael Naveau, Perrine Brazo, Annick Razafimandimby, Sonia Dollfus, Marc Joliot
The dysconnectivity theory of schizophrenia proposes that schizophrenia symptoms arise from abnormalities in neuronal synchrony. Resting-state Functional Connectivity (FC) techniques allow us to highlight synchronization of large-scale networks, the Resting-state Networks (RNs). A large body of work suggests that disruption of RN synchronization could give rise to specific schizophrenia symptoms. The present study aimed to explore within- and between-network FC strength of 34 RNs in 29 patients suffering from schizophrenia, and their relationships with schizophrenia symptoms...
April 12, 2017: Psychiatry Research
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