keyword
https://read.qxmd.com/read/37378842/nidus-compacity-determined-by-semi-automated-segmentation-is-a%C3%A2-strong-quantitative-predictor-of-brain-arterio-venous-malformation-cure
#21
JOURNAL ARTICLE
Aurélien Pacini, Eimad Shotar, Benjamin Granger, Franck Maizeroi-Eugène, Mariette Delaitre, Atika Talbi, Anne-Laure Boch, Charles-Ambroise Valéry, Kévin Premat, Mehdi Drir, Stéphanie Lenck, Charbel Mounayer, Nader-Antoine Sourour, Frédéric Clarençon
BACKGROUND AND OBJECTIVE: A compact nidus is a well-known feature of good outcome after treatment in brain arteriovenous malformations (bAVM). This item, included in the "Supplementary AVM grading system" by Lawton, is subjectively evaluated on DSA. The present study aimed to assess whether quantitative nidus compacity along with other angio-architectural bAVM features were predictive of angiographic cure or the occurrence of procedure-related complications. MATERIALS AND METHODS: Retrospective analysis of 83 patients prospectively collected data base between 2003 to 2018 having underwent digital subtraction 3D rotation angiography (3D-RA) for pre-therapeutic assessment of bAVM...
June 28, 2023: Clinical Neuroradiology
https://read.qxmd.com/read/37158139/deficiency-in-hht-associated-endoglin-elicits-hypoxia-driven-congestive-heart-failure-in-zebrafish
#22
JOURNAL ARTICLE
Etienne Lelièvre, Charlotte Bureau, Yann Bordat, Maxence Frétaud, Christelle Langevin, Chris Jopling, Karima Kissa
Hereditary hemorrhagic Telangiectasia (HHT) is a rare genetic disease caused by mutations affecting components of Bone Morphogenetic Protein and Transforming Growth Factor-β (BMP/TGF-β) signaling in endothelial cells. This disorder is characterized by arterio-venous malformations which are prone to rupture and the ensuing hemorrhages are responsible for iron deficiency anemia. Along with Activin receptor-like kinase ALK1, mutations in ENDOGLIN are associated with the vast majority of HHT cases. In this report, we characterized zebrafish endoglin locus and demonstrated that it produces two phylogenetically conserved protein isoforms using a distinctive alternative splicing mechanism...
May 9, 2023: Disease Models & Mechanisms
https://read.qxmd.com/read/37120743/-radiation-induced-tumor-developing-after-radiosurgery-what-are-the-odds
#23
JOURNAL ARTICLE
Roberto Spiegelmann
Stereotactic radiosurgery is a disruptive therapeutic technique that has transformed neurosurgery and the treatment of intracranial tumors in the last few decades. Achieving tumor control rates over 90%, it is performed mostly in a single session, as an outpatient procedure involving no skin cuts, head shaving, or anesthesia, Radiosurgery stands out as a treatment modality with few and mostly transient side effects. Even though ionizing radiation (the energy used in radiosurgery) is known to be cancerogenic, radiosurgery-induced tumors have been exceedingly rare...
April 2023: Harefuah
https://read.qxmd.com/read/37120742/-glioblastoma-multiforme-after-stereotactic-radiosurgery-treatment-for-arterio-venous-malformation
#24
JOURNAL ARTICLE
Saadit Sarah Houri, Marc Vigoda, Jose E Cohen, Yigal Shoshan
Stereotactic radiosurgery (SRS) is a minimally invasive option commissioned in the treatment of intracranial arteriovenous malformations (AVMs). As long-term follow-up data became available, some late adverse effects have been reported, including SRS-induced neoplasia. However, the exact incidence of this adverse effect is unknown. In this article we present and discuss the topic with an unusual case of a young patient who was treated with SRS for AVM and developed a malignant brain tumor.
April 2023: Harefuah
https://read.qxmd.com/read/37094738/isolated-pulmonary-arteriovenous-malformations-associated-with-bmpr2-pathogenic-variants
#25
Mithum Kularatne, Mélanie Eyries, Laurent Savale, Marc Humbert, David Montani
Heritable pulmonary arterial hypertension (PAH) is an uncommon cause of PAH and is associated most frequently with pathogenic variants of BMPR2. Prior studies have described abnormalities in pulmonary arterial, venous, and bronchial artery vessels associated with these pathogenic variants. In this series, we describe two patients who demonstrated pulmonary arteriovenous malformations (AVMs) and incidentally were identified by a next generation sequencing gene panel to carry variants of BMPR2 in the absence of PAH...
August 2023: Chest
https://read.qxmd.com/read/37078175/intracerebral-de-novo-arterio-venous-malformations-as-a-side-effect-of-bevacizumab
#26
JOURNAL ARTICLE
Aysenur Elmali, Rahsan Gocmen, Saadettin Kilickap, Gozde Yazici
INTRODUCTION: Bevacizumab is a monoclonal antibody for the vascular endothelial growth factor receptor and is utilized in the treatment of various tumors. Gastrointestinal perforation/fistula, heart failure, hemorrhage, hypertension, proteinuria/nephrotic syndrome, thromboembolism, posterior reversible encephalopathy syndrome, and necrotizing fasciitis are serious side effects of bevacizumab. Bevacizumab associated de novo brain arterio-venous malformation formation has not been documented in the literature...
April 20, 2023: Journal of Oncology Pharmacy Practice
https://read.qxmd.com/read/37065525/a-report-of-a-rare-case-of-multiple-fibro-adipose-venous-anomaly
#27
L Dhruva Kumar, Anto Gopurathingal, Pramod Chinder, Suraj Hindiskere
INTRODUCTION: Although not described more than a decade ago, fibro adipose vascular anomaly has grown of increasing importance as conventional management of arterio venous malformation with interventional radiology measures carry little success and cause significant morbidity in pediatric age groups like the case report we present here. Surgical resection, even though requiring significant loss of muscle bulk, is the mainstay of the treatment. CASE REPORT: An 11-year-old patient presented with equinus deformity and intensely tender calf and foot swellings in the right leg...
June 2022: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/37063011/wide-ranging-clinical-spectrum-of-paradoxical-embolism
#28
REVIEW
Oscar Jolobe
The purpose of this review is to raise the index of suspicion for paradoxical embolism among generalists. The review is based solely on anecdotal reports compiled from EMBASE, MEDLINE, Googlescholar and Pubmed. Search terms were 'paradoxical embolism', 'pulmonary embolism' and 'pulmonary arteriovenous malformations'. What emerged was that right-to-left paradoxical embolism could occur with or without concurrent pulmonary embolism, and also with and without proof of the presence of an 'embolus-in-transit'. Potential sites of single or multiple systemic involvement included the central nervous system, the coronary circulation, renal arterial circulation, splenic circulation, the mesenteric circulation and the limbs...
December 1, 2022: Postgraduate Medical Journal
https://read.qxmd.com/read/36993588/genetic-dysregulation-of-an-endothelial-ras-signaling-network-in-vein-of-galen-malformations
#29
Shujuan Zhao, Kedous Y Mekbib, Martijn A van der Ent, Garrett Allington, Andrew Prendergast, Jocelyn E Chau, Hannah Smith, John Shohfi, Jack Ocken, Daniel Duran, Charuta G Furey, Hao Thi Le, Phan Q Duy, Benjamin C Reeves, Junhui Zhang, Carol Nelson-Williams, Di Chen, Boyang Li, Timothy Nottoli, Suxia Bai, Myron Rolle, Xue Zeng, Weilai Dong, Po-Ying Fu, Yung-Chun Wang, Shrikant Mane, Paulina Piwowarczyk, Katie Pricola Fehnel, Alfred Pokmeng See, Bermans J Iskandar, Beverly Aagaard-Kienitz, Adam J Kundishora, Tyrone DeSpenza, Ana B W Greenberg, Seblewengel M Kidanemariam, Andrew T Hale, James M Johnston, Eric M Jackson, Phillip B Storm, Shih-Shan Lang, William E Butler, Bob S Carter, Paul Chapman, Christopher J Stapleton, Aman B Patel, Georges Rodesch, Stanislas Smajda, Alejandro Berenstein, Tanyeri Barak, E Zeynep Erson-Omay, Hongyu Zhao, Andres Moreno-De-Luca, Mark R Proctor, Edward R Smith, Darren B Orbach, Seth L Alper, Stefania Nicoli, Titus J Boggon, Richard P Lifton, Murat Gunel, Philip D King, Sheng Chih Jin, Kristopher T Kahle
To elucidate the pathogenesis of vein of Galen malformations (VOGMs), the most common and severe congenital brain arteriovenous malformation, we performed an integrated analysis of 310 VOGM proband-family exomes and 336,326 human cerebrovasculature single-cell transcriptomes. We found the Ras suppressor p120 RasGAP ( RASA1 ) harbored a genome-wide significant burden of loss-of-function de novo variants (p=4.79×10 -7 ). Rare, damaging transmitted variants were enriched in Ephrin receptor-B4 ( EPHB4 ) (p=1...
March 21, 2023: bioRxiv
https://read.qxmd.com/read/36864993/mandibular-arteriovenous-malformation-with-unusual-radiographic-appearance
#30
Nafiseh Shamloo, Fatemeh Mashhadiabbas, Roohallah Safarpour
Arteriovenous malformation of head and neck is a rare vascular anomaly but when present, it is persistent and progressive in nature. It can also represent a lethal benign disease due to massive hemorrhage. There are several indications for treatment including age, location, extension and type of vascular malformation. Endovascular therapy can effectively cure most lesions with limited tissue involvement. Surgery can be used in selected cases in combination with embolization. Here, we present a rare case of arteriovenous malformation of mandible with floating tooth appearance in an 11-year-old boy patient...
March 2023: Journal of Dentistry
https://read.qxmd.com/read/36824547/management-of-brain-arteriovenous-malformations-a-review
#31
REVIEW
Nitesh Naranbhai, Raúl Pérez
Brain arteriovenous malformations (bAVM) are vascular malformations of the brain affecting all ages. The optimum management strategy is essentially devoid of high-quality evidence and is highly nuanced and embedded in local customs. This study summarizes the frequently employed management strategies, drawing conclusions on the utility of each method of treatment and delving into controversies surrounding them. A literature search on PubMed and Medline was done on January 3rd , 2022. 11,767 articles were found, and abstracts were reviewed...
January 2023: Curēus
https://read.qxmd.com/read/36635031/pulmonary-arterio-venous-malformation-on-endobronchial-ultrasound-bronchoscopy
#32
JOURNAL ARTICLE
Nishant Kumar Chauhan, Rengarajan Rajagopal, Benhur Joel Shadrach, Naveen Dutt
No abstract text is available yet for this article.
February 2023: Thorax
https://read.qxmd.com/read/36565106/development-of-hemodynamically-relevant-acquired-arterio-venous-fistulae-in-patients-with-venous-malformations
#33
JOURNAL ARTICLE
D Schramm, W A Wohlgemuth, M Guntau, M Wieprecht, A Deistung, O Bidakov, M Wildgruber, R Brill, B Cucuruz
BACKGROUND: Venous malformations tend to retain their slow-flow behavior, even in progressive disease or regression following therapy. OBJECTIVE: The aim of this study is to analyze the development of acquired hemodynamic relevant arterio-venous fistulae in patients with slow-flow malformations. METHODS: This study is a retrospective analysis based on a consecutive local registry at a tertiary care Interdisciplinary Center for Vascular Anomalies...
December 23, 2022: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/36562626/commentary-microsurgical-resection-of-a-t8-spinal-cord-arterio-venous-malformation-2-dimensional-operative-video
#34
JOURNAL ARTICLE
Nasser M F El-Ghandour
No abstract text is available yet for this article.
December 23, 2022: Operative Neurosurgery (Hagerstown, Md.)
https://read.qxmd.com/read/36552966/hereditary-hemorrhagic-telangiectasia-a-case-series-experience-from-a-liver-transplant-center-in-romania
#35
Christopher Pavel, Teodor Cabel, Dragoș Dinuță, Alexandru Zaharia, Simona Olimpia Dima, Vasile Sandru, Mugur Cristian Grasu, Mariana Mihaila
Hereditary hemorrhagic telangiectasia (HHT) has significant morbidity due to multiorgan involvement and an unpredictable disease course. We analyzed the data of 14 patients diagnosed with HHT. The case series comprised 14 patients with a median age at presentation of 48 years old (41-74 years). In twelve patients (85.7%), the diagnosis was confirmed by using the Curacao Criteria. The most common reason for admission was epistaxis, with 9 patients (57%) presenting with nosebleed refractory to prolonged self-tamponade...
November 26, 2022: Diagnostics
https://read.qxmd.com/read/36411595/susceptibility-weighted-imaging-for-qualitative-grading-of-persistent-arteriovenous-shunting-in-deep-seated-arteriovenous-malformations-after-stereotactic-radiation-surgery
#36
JOURNAL ARTICLE
Charlie Chia-Tsong Hsu, Igor Fomin, Bradley Wray, Adam Brideaux, Duncan Lyons, Mahendrah Jaya Kumar, Trevor Watkins, E Mark Haacke, Timo Krings
BACKGROUND AND PURPOSE: To investigate Susceptibility Weighted Imaging (SWI) signal changes in the draining vein of deep-seated arterio-venous malformations (AVMs) following stereotactic radiosurgery (SRS). METHODS AND MATERIALS: This is a retrospective study of 32 patients with deep-seated AVMs who were treated with SRS. Pre-SRS treatment and post-SRS treatment MRI were performed at 6, 12, and 24-month intervals. Deep-seated AVMs were classified based on their anatomical location and venous drainage pattern...
November 21, 2022: Neuroradiology Journal
https://read.qxmd.com/read/36259024/orbital-venolymphatic-malformation-treated-with-sodium-tetradecyl-sulfate-a-case-report
#37
Sucharita Das, Ajai Agrawal, Sandeep K Burathoki, Khanak K Nandolia, Aarzoo Juneja, Ramanuj Samanta
Orbital and periorbital venolymphatic malformations (VLMs) are benign congenital vascular lesions and constitute 1%-3% of all orbital masses. Widespread facial venous malformations have a high incidence of associated intracranial developmental venous anomalies (DVAs). In such cases, there can be a sudden increase in proptosis following upper respiratory infection or minor trauma. Numerous percutaneous intralesional sclerosing agents like sodium tetradecyl sulfate (STS), bleomycin, doxycycline, ethanol, and OK-432 (Picibanil) have been used for treating VLMs...
September 2022: Curēus
https://read.qxmd.com/read/36203916/spinal-arteriovenous-malformation-a-case-report-and-review-of-literature
#38
Frank Nketiah Boakye, Raphael Kofi Vowotor, Ronald Awoonor-Williams, Paa Kwesi Baidoo, Dickson Bandoh, Hadi Dodi Abdullah
Spinal arteriovenous malformations are rare vascular anomalies within the paediatric age group. These anomalies are associated with devastating consequences and require prompt management to prevent the long-term neurological sequelae. We report a case of a 10-year-old boy with tetraparesis secondary to spinal arterio- venous malformation type III (Juvenile AVM) with rapidly deteriorating neurological signs who had to be managed conservatively due to lack of advanced neurosurgical facilities and interventional radiological services in our facility and sub region...
January 2022: Journal of the West African College of Surgeons
https://read.qxmd.com/read/36147015/efficacy-and-safety-of-venous-sac-embolization-with-or-without-feeding-artery-embolization-versus-feeding-artery-embolization-alone-in-the-management-of-pulmonary-arteriovenous-malformations-a-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Avichala Taxak, Mansi Verma, Niraj Nirmal Pandey, Vishwajeet Singh, Sanjeev Kumar, Priya Jagia
PURPOSE: To evaluate by meta-analysis the safety and efficacy of venous sac embolization (VSE) with or without feeding artery embolization versus feeding artery embolization (FAE) alone in the management of pulmonary arteriovenous malformations (PAVMs). METHODS: This systematic review and meta-analysis was performed and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic literature search was performed in MEDLINE, Embase, and Scopus till August 31, 2021 to identify studies comparing the safety and efficacy of VSE with or without FAE versus FAE alone in PAVMs...
September 22, 2022: Journal of Endovascular Therapy
https://read.qxmd.com/read/36089478/diagnosis-and-management-of-persistent-pulmonary-arterio-venous-malformations-following-embolotherapy
#40
REVIEW
Chinmay Bhimaji Kulkarni, Patrik Sutphin, Shams Iqbal, Sanjeeva P Kalva
Embolotherapy is the primary treatment for pulmonary arterio-venous malformations (PAVMs). Approximately, 2-25% of PAVMs demonstrate persistence following embolization. Early identification and treatment of persistent PAVMs are critical to mitigating life threatening complications. The presence of prior embolic devices and complex angioarchitecture of persistent PAVMs pose technical challenges during repeat embolotherapy. In this article, we review patterns of persistence, factors affecting the persistence, endovascular treatment techniques, and outcomes...
September 8, 2022: Academic Radiology
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