Gisèle Pickering, Véronique Morel, Estelle Simen, Jean-Michel Cardot, Fares Moustafa, Noémie Delage, Pascale Picard, Sylvie Eschalier, Sylvia Boulliau, Claude Dubray
Studies in animals and in patients have suggested that magnesium (Mg), a physiological blocker of N-methyl-D-aspartate receptor, could have an antinociceptive effect in painful situations. This randomised, double-blind, controlled trial in two parallel groups aims at studying oral Mg effects in patients with neuropathic pain. It explores the impact of Mg (6x419 mg Mg chloride/capsule per day for a month), versus placebo (lactose) on pain [Neuropathic Pain Symptom Inventory (NPSI) and numerical scale (NS)], and on quality of life indicators after 4 weeks treatment, in 45 patients suffering from neuropathic pain...
June 2011: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium