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magnesium neuropathic pain

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https://www.readbyqxmd.com/read/27884758/magnesium-enhances-opioid-induced-analgesia-what-we-have-learnt-in-the-past-decades
#1
REVIEW
Magdalena Bujalska-Zadrożny, Jan Tatarkiewicz, Kamila Kulik, Małgorzata Filip, Marek Naruszewicz
Opioids are increasingly used in alleviating pain, including cancer-related pain and postoperative pain. Unfortunately, the development of tolerance, the resistance of neuropathic pain on opioid analgesia or other undesirable effects may limit their utility. In order to reduce opioid doses, and thereby to avoid the risk of side effects and sudden deaths due to overdosing, attempts have been made to introduce co-analgesics. Due to an increasing amount of data concerning a potential enhance of opioid analgesia by the physiological antagonist of N-methyl-d-aspartate receptors, magnesium ions (Mg(2+)), a concomitant use of such a combination seems to be interesting from a clinical point of view...
November 21, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27723172/antinociceptive-effect-of-systemically-administered-dipyrone-metamizol-magnesium-chloride-or-both-in-a-murine-model-of-cancer
#2
B E Brito, E Vazquez, P Taylor, Y Alvarado, H Vanegas, A Millan, V Tortorici
BACKGROUND: Opioid effectiveness to treat cancer pain is often compromised by the development of tolerance and the occurrence of undesirable side effects, particularly during long-term treatment. Hence, the search for more efficient analgesics remains a necessity. The main goal of this study was to relieve neuropathic symptoms associated with tumour growth by administering the non-opioid analgesic dipyrone (DIP) alone or in combination with magnesium chloride (MgCl2 ), an adjuvant that blocks the NMDA receptor channel...
October 10, 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/26674497/magnesium-oral-supplementation-to-reduce-pain-in-patients-with-severe-peripheral-arterial-occlusive-disease-the-mag-paper-randomised-clinical-trial-protocol
#3
RANDOMIZED CONTROLLED TRIAL
Monica Aida Venturini, Sergio Zappa, Cosetta Minelli, Stefano Bonardelli, Laura Lamberti, Luca Bisighini, Marta Zangrandi, Maddalena Turin, Francesco Rizzo, Andrea Rizzolo, Nicola Latronico
INTRODUCTION: Magnesium exerts analgaesic effects in several animal pain models, as well as in patients affected by acute postoperative pain and neuropathic chronic pain. There is no evidence that magnesium can modulate pain in patients with peripheral arterial occlusive disease (PAOD). We describe the protocol of a single-centre randomised double-blind clinical trial aimed at assessing the efficacy of oral magnesium supplementation in controlling severe pain in patients with advanced PAOD...
2015: BMJ Open
https://www.readbyqxmd.com/read/26485261/targeting-neuropathic-pain-consider-these-alternatives
#4
REVIEW
Mary Onysko, Presley Legerski, Jessica Potthoff, Michael Erlandson
When patients with painful peripheral neuropathy fail to respond to--or are unable to tolerate--standard therapies, consider these lesser-known treatments.
August 2015: Journal of Family Practice
https://www.readbyqxmd.com/read/25796020/effects-of-combining-methylprednisolone-with-magnesium-sulfate-on-neuropathic-pain-and-functional-recovery-following-spinal-cord-injury-in-male-rats
#5
COMPARATIVE STUDY
Leila Farsi, Maryam Naghib Zadeh, Khashayar Afshari, Abbas Norouzi-Javidan, Mahsa Ghajarzadeh, Zeinab Naghshband, Mansoor Keshavarz
Methylprednisolone (MP) has been widely used as a standard therapeutic agent for the treatment of spinal cord injury (SCI). Because of its controversial useful effects, the combination of MP and other pharmacological agents to enhance neuroprotective effects is desirable. Magnesium sulfate (MgSO4) has been shown to have neuroprotective and antihyperalgesic effects. In the present study, we sought to determine the effect of combining MP and MgSO4, on neuropathic pain and functional recovery following spinal cord injury (SCI) in male rats...
2015: Acta Medica Iranica
https://www.readbyqxmd.com/read/25723604/-perioperative-management-of-patients-with-opioid-tolerance-and-misuse
#6
REVIEW
Carsten Stoetzer, Andreas Leffler, Jörg Filitz
Patients with opioid pretreatment can be divided into different groups.While patients after successful drug addiction treatment with or without drug replacement therapy usually not require an extensive perioperative pain therapy, patients with persistent chronic pain and patients with an existing opioid addiction regularly are challenging for the anesthetist. Important pathophysiological issues among the patients include opioid tolerance, opioid-induced hyperalgesia (OIH) as well as acute withdrawal symptomes...
February 2015: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/25450160/preventive-analgesia-in-hip-or-knee-arthroplasty-a-systematic-review
#7
J Díaz-Heredia, E Loza, I Cebreiro, M Á Ruiz Iban
OBJECTIVE: To analyze the efficacy and safety of preventive analgesia in patients undergoing hip or knee arthroplasty due to osteoarthritis. METHODS: A systematic literature review was performed, using a defined a sensitive strategy on Medline, Embase and Cochrane Library up to May 2013. The inclusion criteria were: patients undergoing knee and/or hip arthroplasty, adults with moderate or severe pain (≥4 on a Visual Analog Scale). The intervention, the use (efficacy and safety) of pharmacological treatment (preventive) close to surgery was recorded...
March 2015: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/25369748/postinjury-treatment-with-magnesium-sulfate-attenuates-neuropathic-pains-following-spinal-cord-injury-in-male-rats
#8
Leila Farsi, Khashayar Afshari, Mansoor Keshavarz, Maryam NaghibZadeh, Fereidoon Memari, Abbas Norouzi-Javidan
Spinal cord injury (SCI) has a number of severe and disabling consequences including chronic pain. Approximately 40% of patients experience neuropathic pain, which appears to be persistent. Previous studies have demonstrated the neuroprotective effects of magnesium sulfate (MgSO4). We aimed to investigate the effect of MgSO4 on neuropathic pains following SCI in male rats. Thirty-two adult male rats (weight 300-350 g) were used. After laminectomy, a complete SCI was induced by compression of the spinal cord for 1 min with an aneurysm clip...
April 2015: Behavioural Pharmacology
https://www.readbyqxmd.com/read/24577345/additive-effect-of-combined-application-of-magnesium-and-mk-801-on-analgesic-action-of-morphine
#9
Magdalena Bujalska-Zadrożny, Kamila Duda
As previously reported, magnesium ions (Mg(2+)) administered in relatively low doses markedly potentiated opioid analgesia in neuropathic pain, in which the effectiveness of opioids is limited. Considering that Mg(2+) behaves like an N-methyl-D-aspartate receptor antagonist, the effect of this ion on the analgesic action of morphine was compared with that of MK-801. Acute pain was evoked by mechanical or thermal stimuli, whereas neuropathic hyperalgesia was induced by streptozotocin (STZ) administration. Magnesium sulphate (40 mg/kg i...
2014: Pharmacology
https://www.readbyqxmd.com/read/24077207/magnesium-l-threonate-prevents-and-restores-memory-deficits-associated-with-neuropathic-pain-by-inhibition-of-tnf-%C3%AE
#10
Jun Wang, Yong Liu, Li-Jun Zhou, Ying Wu, Fei Li, Ka-Feng Shen, Rui-Ping Pang, Xu-Hong Wei, Yong-Yong Li, Xian-Guo Liu
BACKGROUND: Clinical studies have shown that about two-thirds of patients with chronic pain suffer from short-term memory (STM) deficits and an effective drug for treatment of the neurological disorder is lacking at present. OBJECTIVE: We tested whether chronic oral application of magnesium L-threonate (MgT), which has been shown to improve memory in normal and aging animals by elevating Mg2+ in the brain, could prevent or restore the STM deficits induced by spared nerve injury (SNI), an animal model of chronic neuropathic pain...
September 2013: Pain Physician
https://www.readbyqxmd.com/read/23712613/intravenous-lidocaine-and-magnesium-for-management-of-intractable-trigeminal-neuralgia-a-case-series-of-nine-patients
#11
Young-Chang P Arai, Noboru Hatakeyama, Makoto Nishihara, Masahiko Ikeuchi, Makoto Kurisuno, Tatsunori Ikemoto
Most patients suffering from trigeminal neuralgia (TN) benefit from medical therapy, for example carbamazepin, gabapentin, and pregabalin, individually or in combination. Nonetheless, some patients experience severe and intractable pain despite such medication, or the medication eliminates their pain but they experience intolerable side effects sufficient to warrant discontinuation. Intravenous magnesium and lidocaine have been used for management of intractable neuropathic pain. We treated nine patients with TN by using an intravenous infusion of a combination of 1...
December 2013: Journal of Anesthesia
https://www.readbyqxmd.com/read/23384256/a-double-blinded-randomised-controlled-study-of-the-value-of-sequential-intravenous-and-oral-magnesium-therapy-in-patients-with-chronic-low-back-pain-with-a-neuropathic-component
#12
RANDOMIZED CONTROLLED TRIAL
A A Yousef, A E Al-deeb
Persistent mechanical irritation of the nerve root sets up a series of events mediating sensitisation of the dorsal roots and dorsal horns in the spinal cord. Current evidence supports the role of magnesium in blocking central sensitisation through its effect on N-methyl-d-aspartate receptors. We studied the role of sequential intravenous and oral magnesium infusion in patients with chronic low back pain with a neuropathic component. We recruited a cohort of 80 patients with chronic low back pain with a Leeds Assessment of Neuropathic Signs and Symptoms pain scale score ≥ 12, who were receiving a physical therapy programme...
March 2013: Anaesthesia
https://www.readbyqxmd.com/read/21659058/oral-magnesium-treatment-in-patients-with-neuropathic-pain-a-randomized-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Gisèle Pickering, Véronique Morel, Estelle Simen, Jean-Michel Cardot, Fares Moustafa, Noémie Delage, Pascale Picard, Sylvie Eschalier, Sylvia Boulliau, Claude Dubray
Studies in animals and in patients have suggested that magnesium (Mg), a physiological blocker of N-methyl-D-aspartate receptor, could have an antinociceptive effect in painful situations. This randomised, double-blind, controlled trial in two parallel groups aims at studying oral Mg effects in patients with neuropathic pain. It explores the impact of Mg (6x419 mg Mg chloride/capsule per day for a month), versus placebo (lactose) on pain [Neuropathic Pain Symptom Inventory (NPSI) and numerical scale (NS)], and on quality of life indicators after 4 weeks treatment, in 45 patients suffering from neuropathic pain...
June 2011: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/20837644/magnesium-attenuates-chronic-hypersensitivity-and-spinal-cord-nmda-receptor-phosphorylation-in-a-rat-model-of-diabetic-neuropathic-pain
#14
L J Rondón, A M Privat, L Daulhac, N Davin, A Mazur, J Fialip, A Eschalier, C Courteix
Neuropathic pain is a common diabetic complication affecting 8-16% of diabetic patients. It is characterized by aberrant symptoms of spontaneous and stimulus-evoked pain including hyperalgesia and allodynia. Magnesium (Mg) deficiency has been proposed as a factor in the pathogenesis of diabetes-related complications, including neuropathy. In the central nervous system, Mg is also a voltage-dependent blocker of the N-methyl-d-aspartate receptor channels involved in abnormal processing of sensory information...
November 1, 2010: Journal of Physiology
https://www.readbyqxmd.com/read/20478123/coadjuvant-analgesics-for-cancer-pain-using-the-clinical-queries-pubmed-tool
#15
REVIEW
Luis Enrique Chaparro Gómez, José Andrés Calvache España, Lina Marcela Arbeláez León
Coadjuvants for cancer pain are medications that, when added to opioids, can potentially decrease narcotic request and opioid-related side effects. Our goal was to review not only the evidence that supports the effectiveness, but also the mechanisms of action of these drugs. We performed a qualitative review using the PubMed database applying the clinical queries tool to identify therapeutic clinical trials or systematic reviews evaluating cancer pain--oral or transdermal--analgesia. We excluded studies using anti-inflammatories, steroids or narcotics as primary analgesia and studies focused on perioperative cancer pain...
March 2010: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/20081245/magnesium-ions-and-opioid-agonists-in-vincristine-induced-neuropathy
#16
Magdalena Bujalska, Helena Makulska-Nowak, Stanisław W Gumułka
Neuropathic pain is difficult to treat. Classic analgesics (i.e., opioid receptor agonists) usually possess low activity. Therefore other agents such as antidepressants, anticonvulsants, and corticosteroids are used. It is commonly known that NMDA antagonists increase analgesic activity of opioids. Unfortunately, clinical use of NMDA antagonists is limited because of the relatively frequent occurrence of adverse effects e.g., memory impairment, psychomimetic effects, ataxia and motor in-coordination. Magnesium ions (Mg(2+)) are NMDA receptor blockers in physiological conditions...
November 2009: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/18971294/omega-conotoxin-gvia-alters-gating-charge-movement-of-n-type-cav2-2-calcium-channels
#17
Viktor Yarotskyy, Keith S Elmslie
omega-conotoxin GVIA (omegaCTX) is a specific blocker of N-type calcium (CaV2.2) channels that inhibits neuropathic pain. While the toxin appears to be an open channel blocker, we show that N-channel gating charge movement is modulated. Gating currents were recorded from N-channels expressed along with beta2a and alpha2delta subunits in HEK293 cells in external solutions containing either lanthanum and magnesium (La-Mg) or 5 mM Ca2+ plus omegaCTX (omegaCTX-Ca). A comparison showed that omegaCTX induced a 10-mV right shift in the gating charge versus voltage (Q-V) relationship, smaller off-gating current time constant (tau Q(Off)), a lower tau Q(Off) voltage dependence, and smaller on-gating current (Q(On)) tau...
January 2009: Journal of Neurophysiology
https://www.readbyqxmd.com/read/18701828/magnesium-ions-and-opioid-agonist-activity-in-streptozotocin-induced-hyperalgesia
#18
Magdalena Bujalska, Ewelina Malinowska, Helena Makulska-Nowak, Stanisław Witold Gumułka
Streptozotocin-induced hyperglycemia accompanied by a chronic decrease in the nociceptive threshold is considered a useful model of experimental hyperalgesia. We examined (1) the effect of the opioid receptor agonists and (2) the effect of the magnesium ions (Mg(2+)) on the antinociceptive action of opioid agonists in a diabetic neuropathic pain model. When administered alone, opioid agonists like morphine (5 mg/kg i.p.) and fentanyl (0.0625 mg/kg i.p.), as well as the partial agonist buprenorphine (0.075 mg/kg) had only little effect on streptozotocin-induced hyperalgesia...
2008: Pharmacology
https://www.readbyqxmd.com/read/17410641/markedly-attenuated-acute-and-chronic-pain-responses-in-mice-lacking-adenylyl-cyclase-5
#19
K-S Kim, J Kim, S K Back, J-Y Im, H S Na, P-L Han
Chronic inflammatory and neuropathic pain is often difficult to manage using conventional remedies. The underlying mechanisms and therapeutic strategies required for the management of chronic pain need to be urgently established. The cyclic AMP (cAMP) second messenger system has been implicated in the mechanism of nociception, and the inhibition of the cAMP pathway by blocking the activities of adenylyl cyclase (AC) and protein kinase A has been found to prevent chronic pain in animal models. However, little is known regarding which of the 10 known isoforms of AC are involved in nociceptive pathways...
March 2007: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/17410603/effects-of-polyethylene-glycol-and-magnesium-sulfate-administration-on-clinically-relevant-neurological-outcomes-after-spinal-cord-injury-in-the-rat
#20
David S Ditor, Sunil M John, Josee Roy, Jeffrey C Marx, Colin Kittmer, Lynne C Weaver
The purpose of this study was to determine the long-term effects of polyethylene glycol (PEG) and magnesium sulfate (MgSO(4)) on clinically relevant motor, sensory, and autonomic outcomes after spinal cord injury (SCI). Rats were injured by clip compression (50 g; T4) and treated 15 min and 6 hr postinjury intravenously (tail vein) with PEG (1 g/kg, 30% w/w in saline; n = 11), MgSO(4) (300 mg/kg; n = 5), PEG + MgSO(4) (n = 6), or saline (n = 10). Behavioral testing lasted for 6 weeks, followed by histological analysis of the spinal cord...
May 15, 2007: Journal of Neuroscience Research
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