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https://www.readbyqxmd.com/read/29783268/lipidomic-components-alterations-of-human-follicular-fluid-reveal-the-relevance-of-improving-clinical-outcomes-in-women-using-progestin-primed-ovarian-stimulation-compared-to-short-term-protocol
#1
Xiaowei Wen, Yanping Kuang, Lixia Zhou, Baofeng Yu, Qiuju Chen, Yonglun Fu, Zheng Yan, Haiyan Guo, Qifeng Lyu, Jun Xie, Weiran Chai
BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes...
May 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29783242/specific-nature-of-changes-in-main-immunohistochemical-parameters-of-neoangiogenesis-in-patients-with-psoriasis
#2
Iryna Ya Voznyak, Оrysya О Syzon, Marianna O Dashko
OBJECTIVE: Introduction: Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. Taking into consideration the data of scientific investigation, at present psoriasis is explained as genetically determined chronic multi factor polysystemic dermatosis. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization, depending on psoriasis form and severity of the course of pathological processes...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783238/clinical-efficiency-of-dynamic-observation-of-patients-with-epidermal-dysplasia-of-the-skin
#3
Oleg L Ziukov, Оlena O Oshyvalova
OBJECTIVE: Introduction: Non-melanoma skin cancer is the most common type of cancer among the population of Ukraine. The aim: The study of clinical efficacy of dynamic observation of patients with epidermal dysplasia of the skin. PATIENTS AND METHODS: Materials and methods: To study epidermal dysplasia of the skin there was used identifying information of patients, who were under dynamic observation of dermatologists of the State Scientific Institution "Research and Practical Centre of Preventive and Clinical Medicine" of the State Administration in 2013-2017...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783236/clinical-aspects-of-gastropathy-development-in-patients-with-chronic-obstructive-pulmonary-disease
#4
Anna V Chetaikina, Helen Ye Sklyarova, Iryna V Shalko, Roman Ya Dutka
OBJECTIVE: Introduction: Chronic obstructive pulmonary disease (COPD) is a one of the main reasons of disability and mortality in the world. The essential attention is dedicated to the combination of COPD and erosive/ulcer defects with the haemorrhage risk factor. The aim was to compare gastric acidity and mucoid secretion in patients with chronic obstructive pulmonary disease of gastropathy development. PATIENTS AND METHODS: Materials and methods: 94 patients with gastroduodenal erosive and ulcerous defects combined with COPD were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783225/-features-of-exchange-of-calcium-saliva-in-patients-with-gastroesophageal-reflux-disease
#5
Mykola А Bychkov, Maryana М Yakhnitska
OBJECTIVE: Introduction: The pathogenesis of gastroesophageal reflux disease (GERD) is a topical issue of modern gastroenterology. There are a number of scientific papers on changes in the qualitative and quantitative composition of saliva, which triggers a cascade of biochemical reactions, the consequence of which is the destruction of the resistance of the mucous membrane of the esophagus. Calcium is a macro element that provides the normal functioning of cells. Parathormone also regulates the metabolism of calcium in the body...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783221/hygienic-assessment-of-different-forms-of-physical-education-lessons-organization-in-primary-school
#6
Oleksandra S Kondratiuk, Maria M Korshun, Sergii I Garkavyi, Sergii S Garkavyi, Liudmyla A Stasiuk, Olena V Dema, Olga O Sokolovska
OBJECTIVE: Introduction: Different forms of physical education lessons organization, including swimming classes were introduced in education process without studying of its healthsaving effectiveness. The aim of this study was hygienic assessment of different forms of physical education lessons organization in primary school. PATIENTS AND METHODS: Materials and methods: Cross-sectional study was conducted in two schools with different organization of physical education lessons...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783216/-complex-of-psycho-hygienic-correction-measures-of-personality-features-of-hiv-infected-men-and-evaluation-of-their-efficiency
#7
Ihor V Serheta, Oksana B Dudarenko, Olha P Mostova, Tetiana V Lobastova, Vitalii M Andriichuk, Larysa M Vakolyuk, Olha M Yakubovska
OBJECTIVE: Introduction: In addition to adequate diagnosis and treatment of HIV-infected individuals, development, scientific substantiation and implementation of psycho-hygienic measures aimed at correcting the processes of forming personality traits and improving the psycho-emotional state of HIV-infected individuals are of particular importance. The aim: The purpose of the scientific research was to determine the most significant changes of situational and personal anxiety indicators, the degree of gravity of the asthenic state and depressive manifestations that were recorded in the context of the introduction of a number of measures for psycho-hygienic correction...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783215/the-changes-of-some-bioregulators-and-gas-transmitters-in-patients-with-hypertonic-disease-under-the-influence-of-physical-loading
#8
Iryna S Dronyk, Ostap H Yavorsky, Olexandr Y Sklyarov
OBJECTIVE: Introduction: Nowadays arterial hypertension is supposed to be a pathogenetic factor of numerous cardiovascular diseases (CVD) and 18% cases of the preterm death. Due to the data of the American Heart Association in 77% of patients, who had stroke, the arterial pressure overexceeded 140/90 mm Hg. In Ukraine, according to the epidemiologic study more than 1/3 of the population have increased arterial pressure. One of the extremely important aspects of struggle with CVD is diagnosis and prevention of hypertonic disease...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783205/individual-approach-to-the-treatment-of-obese-copd-patients-can-reduce-anthropometric-indicators-the-level-of-systemic-inflammation-and-improve-the-quality-of-life
#9
Lesia V Savchenko, Igor P Kaidashev
OBJECTIVE: Introduction: Chronic obstructive pulmonary disease (COPD) and obesity are major causes of morbidity and mortality worldwide, and according to current estimates, the global burden of these conditions will be even greater. The basis for COPD treatment is bronchodilator therapy and non-pharmacotherapy approaches, such as respiratory rehabilitation and dietary counseling. The aim of this study was to assess the impact of lifestyle modification on anthropometric indices, markers of systemic inflammation, quality of life in patients with COPD and obesity...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783200/blood-lead-and-cadmium-levels-in-preschool-children-and-associated-risk-factors-in-s%C3%A3-o-paulo-brazil
#10
Kelly Polido Kaneshiro Olympio, Júlia Prestes da Rocha Silva, Agnes Soares da Silva, Vanessa Cristina de Oliveira Souza, Marília Afonso Rabelo Buzalaf, Fernando Barbosa, Maria Regina Alves Cardoso
In Brazil, there are scarce data on lead (Pb) and cadmium (Cd) contamination, especially for more vulnerable populations such as preschool children. In this paper, we answer two questions: (1) What are the exposure levels of lead and cadmium in preschool children, in Sao Paulo, Brazil? and (2) What are the risk factors associated with this exposure? This cross-sectional study included 50 day care centers (DCCs), totaling 2463 children aged 1-4 years. Venous blood samples were analyzed by ICP-MS. Questionnaires were administered to the parents...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29783198/toxicity-assessment-of-metal-oxide-nano-pollutants-on-tomato-solanum-lycopersicon-a-study-on-growth-dynamics-and-plant-cell-death
#11
Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat
The present study for the first time demonstrated the interactions of metal oxide (MO) nano-pollutants (CuO and Al2 O3 -NPs) with tissues and cellular DNA of tomato plants grown in soil sand: silt: clay (667:190:143) and Hoagland-hydroponic system and assessed the hazardous effects of NPs on cell physiology and biochemistry. Results of SEM equipped with EDX revealed attachment of variably shaped CuO-NPs (18 nm) and Al2 O3 -NPs (21 nm) on roots, and internalization followed by translocation in plants by ICP-MS and TEM...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29783189/sall2-knockdown-exacerbates-palmitic-acid-induced-dysfunction-and-apoptosis-of-pancreatic-nit-1-beta-cells
#12
Ye Wang, Jie Liu, Zheng Liu, Jing Chen, Xuemei Hu, Yimeng Hu, Yin Yuan, Guijun Wu, Zhe Dai, Yancheng Xu
Spalt-like (Sall) proteins are a class of transcription factors. The role of Sall2 in beta cells remain poorly understood. Here, we aimed to explore whether Sall2 involved in lipotoxicity-mediated dysfunction and apoptosis in pancreatic NIT-1 beta cells. Our results showed that high concentrations of palmitic acid (PA) led to impaired cell viability and decreased Sall2 expression in NIT-1 cells. Knocking down of Sall2 in NIT-1 cells resulted in increased sensitivity to lipotoxicity and caused higher rates of cell apoptosis following PA treatment...
May 18, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29783182/effects-of-overproduced-ethylene-on-the-contents-of-other-phytohormones-and-expression-of-their-key-biosynthetic-genes
#13
Weiqiang Li, Rie Nishiyama, Yasuko Watanabe, Chien Van Ha, Mikiko Kojima, Ping An, Lei Tian, Chunjie Tian, Hitoshi Sakakibara, Lam-Son Phan Tran
Ethylene is involved in regulation of various aspects of plant growth and development. Physiological and genetic analyses have indicated the existence of crosstalk between ethylene and other phytohormones, including auxin, cytokinin (CK), abscisic acid (ABA), gibberellin (GA), salicylic acid (SA), jasmonic acid (JA), brassinosteroid (BR) and strigolactone (SL) in regulation of different developmental processes. However, the effects of ethylene on the biosynthesis and contents of these hormones are not fully understood...
May 10, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29783173/development-and-validation-of-an-analytical-method-for-regorafenib-and-its-metabolites-in-mouse-plasma
#14
Qiang Fu, Mingqing Chen, Shuiying Hu, Craig A McElroy, Ron H Mathijssen, Alex Sparreboom, Sharyn D Baker
An analytical method was developed for measuring the effect of OATP1B2 deficiency on plasma levels of the kinase inhibitor regorafenib and its metabolites regorafenib-N-oxide, N-desmethyl-regorafenib-N-oxide, and regorafenib-N-β-glucuronide (RG) in mice. Compounds were separated by liquid chromatography and monitored by a triple quadrupole mass spectrometer in the selected reaction monitoring mode after positive electrospray ionization. All calibration curves were linear in the selected concentration range (R2  ≥ 0...
May 5, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29783163/maternal-hypothalamus-pituitary-adrenal-hpa-system-activity-and-stress-during-pregnancy-effects-on-gestational-age-and-infant-s-anthropometric-measures-at-birth
#15
Maria Gilles, Henrike Otto, Isabell A C Wolf, Barbara Scharnholz, Verena Peus, Michael Schredl, Marc W Sütterlin, Stephanie H Witt, Marcella Rietschel, Manfred Laucht, Michael Deuschle
BACKGROUND: Prenatal maternal stress might be a risk for the developing fetus and may have long-lasting effects on child and adult vulnerability to somatic and psychiatric disease. Over-exposure of the unborn to excess glucocorticoids and subsequent alteration of fetal development is hypothesized to be one of the key mechanisms linking prenatal stress with negative child outcome. METHODS: In this prospective longitudinal study, mothers-to-be (n = 405) in late pregnancy (36...
April 22, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29783158/pirfenidone-ameliorates-lipopolysaccharide-induced-pulmonary-inflammation-and-fibrosis-by-blocking-nlrp3-inflammasome-activation
#16
Yi Li, Haitao Li, Shuai Liu, Pinhua Pan, Xiaoli Su, Hongyi Tan, Dongdong Wu, Lemeng Zhang, Chao Song, Minhui Dai, Qian Li, Zhi Mao, Yuan Long, Yongbin Hu, Chengping Hu
Acute respiratory distress syndrome(ARDS)is a severe clinical disorder characterized by its acute onset, diffuse alveolar damage, intractable hypoxemia, and non-cardiogenic pulmonary edema. Acute lung injury(ALI) can trigger persistent lung inflammation and fibrosis through activation of the NLRP3 inflammasome and subsequent secretion of mature IL-1β, suggesting that the NLRP3 inflammasome is a potential therapeutic target for ALI, for which new therapeutic approaches are needed. Our present study aims to assess whether pirfenidone,with anti-fibrotic and anti-inflammatory properties, can improve LPS-induced inflammation and fibrosis by inhibiting NLRP3 inflammasome activation...
May 18, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29783156/transient-impairment-of-olfactory-threshold-in-acute-multiple-sclerosis-relapse
#17
Gabriel Bsteh, Harald Hegen, Felix Ladstätter, Klaus Berek, Matthias Amprosi, Sebastian Wurth, Michael Auer, Franziska Di Pauli, Florian Deisenhammer, Andreas Lutterotti, Thomas Berger
BACKGROUND: Impairment of olfactory threshold is a feature of early and active relapsing remitting multiple sclerosis (RRMS). It predicts inflammatory disease activity and was reported to be transient. However, the timing of onset and resolve of olfactory threshold impairment remains unclear. OBJECTIVE: To prospectively assess the development of olfactory threshold in acute MS relapse over time in comparison to stable MS patients. METHODS: In a prospective observational design, we measured olfactory threshold by performing the Sniffin' Sticks test (minimum score 0, maximum score 16 reflecting optimal olfactory function) at baseline and after 4, 12 and 24 weeks...
May 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29783136/occurrence-and-estrogenic-activity-of-steroid-hormones-in-chinese-streams-a-nationwide-study-based-on-a-combination-of-chemical-and-biological-tools
#18
Bo Yao, Rui Li, Shuwen Yan, Shen-An Chan, Weihua Song
Steroid hormones (SHs) are continuously released into the aquatic environment through various pathways after being excreted by humans and animals, interfere with the normal function of the endocrine system and may affect the physiology and reproduction of exposed aquatic life. To conduct a nationwide investigation of the occurrence and biological effects of SHs in surface river/steam water in China, we quantitated 27 selected SHs in 217 surface water samples by solid-phase extraction (SPE) tandem LC-MS/MS and used a recombinant yeast estrogen assay to screen extracts of the water samples for estrogenic activities...
May 18, 2018: Environment International
https://www.readbyqxmd.com/read/29783119/in-vivo-imaging-of-neuronal-calcium-during-electrode-implantation-spatial-and-temporal-mapping-of-damage-and-recovery
#19
James R Eles, Alberto L Vazquez, Takashi D Y Kozai, X Tracy Cui
Implantable electrode devices enable long-term electrophysiological recordings for brain-machine interfaces and basic neuroscience research. Implantation of these devices, however, leads to neuronal damage and progressive neural degeneration that can lead to device failure. The present study uses in vivo two-photon microscopy to study the calcium activity and morphology of neurons before, during, and one month after electrode implantation to determine how implantation trauma injures neurons. We show that implantation leads to prolonged, elevated calcium levels in neurons within 150 μm of the electrode interface...
May 7, 2018: Biomaterials
https://www.readbyqxmd.com/read/29783090/inter-and-intra-disciplinary-collaboration-and-patient-safety-outcomes-in-u-s-acute-care-hospital-units-a-cross-sectional-study
#20
Chenjuan Ma, Shin Hye Park, Jingjing Shang
BACKGROUND: Collaboration among healthcare providers has been considered a promising strategy for improving care quality and patient outcomes. Despite mounting evidence demonstrating the impact of collaboration on outcomes of healthcare providers, there is little empirical evidence on the relationship between collaboration and patient safety outcomes, particularly at the patient care unit level. OBJECTIVES: The purpose of this study is to identify the extent to which interdisciplinary collaboration between nurses and physicians and intradisciplinary collaboration among nurses on patient care units are associated with patient safety outcomes...
May 2, 2018: International Journal of Nursing Studies
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