João Paulo Tavanez, Rafael Caetano, Cristina Branco, Inês Margarida Brito, Ana Miragaia-Pereira, Tatiana Vassilevskaia, Ana Sofia Quina, Celso Cunha
Hepatitis delta virus (HDV) is the agent responsible for the most severe form of human viral hepatitis. The HDV genome consists of a single-stranded circular RNA molecule that encodes for one single protein, the delta antigen. Given its simplicity, HDV must make use of several host cellular proteins to accomplish its life cycle processes, including transcription, replication, post-transcriptional, and post-translational modifications. Consequently, identification of the interactions established between HDV components and host proteins assumes a pivotal interest in the search of novel therapeutic targets...
September 2020: FEBS Journal