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Early childhood neurodevelopment

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https://www.readbyqxmd.com/read/29128679/early-onset-epileptic-encephalopathy-with-de-novo-scn8a-mutation
#1
Yangyang Xiao, Jie Xiong, Ding'an Mao, Lingjuan Liu, Jian Li, Xingfang Li, Haiyan Luo, Liqun Liu
Early-onset epileptic encephalopathies (EOEEs) are clinically and genetically heterogeneous disorders characterized by intractable seizures and unremitting interictal paroxysmal epileptiform activity. Consequently, these syndromes impair neurodevelopment during the first year of life. Currently, the etiology of these disorders is largely unknown. In this study, Childhood-Onset Epilepsy Gene Panel Testing (containing 511 epilepsy-related genes) was performed in a parent-offspring trio. In this family, the son had refractory seizures, intellectual disability, and motor abnormalities, and he was diagnosed with EOEE...
October 28, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29105061/annual-research-review-not-just-a-small-adult-brain-understanding-later-neurodevelopment-through-imaging-the-neonatal-brain
#2
REVIEW
Dafnis Batalle, A David Edwards, Jonathan O'Muircheartaigh
BACKGROUND: There has been a recent proliferation in neuroimaging research focusing on brain development in the prenatal, neonatal and very early childhood brain. Early brain injury and preterm birth are associated with increased risk of neurodevelopmental disorders, indicating the importance of this early period for later outcome. SCOPE AND METHODOLOGY: Although using a wide range of different methodologies and investigating diverse samples, the common aim of many of these studies has been to both track normative development and investigate deviations in this development to predict behavioural, cognitive and neurological function in childhood...
November 3, 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29072589/the-combined-influence-of-air-pollution-and-home-learning-environment-on-early-cognitive-skills-in-children
#3
Lanair A Lett, Jeanette A Stingone, Luz Claudio
Cognitive skills are one component of school readiness that reflect a child's neurodevelopment and are influenced by environmental and social factors. Most studies assess the impact of these factors individually, without taking into consideration the complex interactions of multiple factors. The objective of this study was to examine the joint association of markers of environmental pollution and of social factors on early cognitive skills in an urban cohort of children. For this, we chose isophorone in ambient air as a marker of industrial air pollution...
October 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28991146/effect-of-caregiver-training-on-the-neurodevelopment-of-hiv-exposed-uninfected-children-and-caregiver-mental-health-a-ugandan-cluster-randomized-controlled-trial
#4
Michael J Boivin, Noeline Nakasujja, Itziar Familiar-Lopez, Sarah M Murray, Alla Sikorskii, Jorem Awadu, Cilly Shohet, Deborah Givon, Horacio Ruiseñor-Escudero, Elizabeth E Schut, Robert O Opoka, Judith K Bass
OBJECTIVE: Early childhood development programs typically combine healthy nutrition and cognitive stimulation in an integrated model. We separately delivered these 2 components in a cluster-randomized controlled trial to evaluate their comparative effectiveness in promoting healthy child development and caregiver mental health. This is the first study to do so for HIV-affected children and their infected mothers. METHODS: Two hundred twenty-one HIV-exposed but uninfected child (2-3 years old) and caregiver dyads in 18 geographic clusters in Eastern Uganda were randomized by cluster to receive biweekly individualized sessions of either (1) Mediational Intervention for Sensitizing Caregivers (MISC) training emphasizing cognitive stimulation or (2) Uganda Community Based Association for Child Welfare (UCOBAC) program that delivered health and nutrition training...
November 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28981842/30-years-on-how-the-neurodevelopmental-hypothesis-of-schizophrenia-morphed-into-the-developmental-risk-factor-model-of-psychosis
#5
Robin M Murray, Vishal Bhavsar, Giada Tripoli, Oliver Howes
At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on aberrant genes and early neural hazards, but then it grew to include ideas concerning aberrant synaptic pruning in adolescence. The hypothesis had its own stormy development and it endured some difficult teenage years when a resurgence of interest in neurodegeneration threatened its survival. In early adult life, it over-reached itself with some reductionists claiming that schizophrenia was simply a neurodevelopmental disease...
October 21, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28969309/duration-of-general-anaesthetic-exposure-in-early-childhood-and-long-term-language-and-cognitive-ability
#6
C Ing, M K Hegarty, J W Perkins, A J O Whitehouse, C J DiMaggio, M Sun, H Andrews, G Li, L S Sun, B S von Ungern-Sternberg
Background: The anaesthetic dose causing neurotoxicity in animals has been evaluated, but the relationship between duration of volatile anaesthetic (VA) exposure and neurodevelopment in children remains unclear. Methods: Data were obtained from the Western Australian Pregnancy Cohort (Raine) Study, with language (Clinical Evaluation of Language Fundamentals: Receptive [CELF-R] and Expressive [CELF-E] and Total [CELF-T]) and cognition (Coloured Progressive Matrices [CPM]) assessed at age 10 yr...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28946583/cognitive-rehabilitation-with-neurodevelopmental-disorder-a-systematic-review
#7
Sinae Ahn, Sujin Hwang
BACKGROUND: A variety of cognitive rehabilitation has gained popularity in early childhood with neurodevelopmental disorder at clinical rehabilitation settings. OBJECTIVES: The purpose of this review was to analyze the cognitive therapies used and to analyze the methods applied in children with neurodevelopmental disorders. METHODS: This study searched for experimental studies published between 2006 and 2016 using two databases including EBSCOhost and PubMed...
September 16, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28923060/vitamin-d-status-and-neurodevelopment-and-growth-in-young-north-indian-children-a-secondary-data-analysis
#8
Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Ingrid Kvestad, Tor A Strand, Maharaj Kishan Bhan
BACKGROUND: Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children. METHODS: We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India...
September 18, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28918504/autism-spectrum-disorders-and-disease-modeling-using-stem-cells
#9
REVIEW
Anita Brito, Fabiele Baldino Russo, Alysson Renato Muotri, Patricia Cristina Baleeiro Beltrão-Braga
Autism spectrum disorders (ASD) represent a variety of disorders characterized as complex lifelong neurodevelopment disabilities, which may affect the ability of communication and socialization, including typical comportments like repetitive and stereotyped behavior. Other comorbidities are usually present, such as echolalia, hypotonia, intellectual disability and difficulties in processing figured speech. Furthermore, some ASD individuals may present certain abilities, such as eidetic memory, outstanding musical or painting talents and special mathematical skills, among others...
September 16, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28917719/polymorphisms-in-manganese-transporters-show-developmental-stage-and-sex-specific-associations-with-manganese-concentrations-in-primary-teeth
#10
Karin Wahlberg, Manish Arora, Austen Curtin, Paul Curtin, Robert O Wright, Donald R Smith, Roberto G Lucchini, Karin Broberg, Christine Austin
BACKGROUND: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. METHODS: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry...
September 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28917084/evaluation-of-neurodevelopment-of-children-with-congenital-hypothyroidism-by-the-denver-developmental-screening-test
#11
Ayşe Derya Buluş, Esra Tiftik
BACKGROUND: Thyroid hormones are essential for growth and brain development in childhood. Although congenital hypothyroidism (CH) is the most common reason for mental retardation, normal neurological development can be achieved through early and effective treatment. The aim of the present study was to evaluate the neurological development of CH patients aged 24-56 months. METHODS: The study included a total of 116 healthy control subjects and 112 patients aged 24-56 months who were diagnosed with CH during the neonatal period and were being followed up at the Pediatric Endocrinology Department, Keçiören Training and Research Hospital, between 2012 and 2015...
October 26, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28901887/microcytosis-is-associated-with-low-cognitive-outcomes-in-healthy-2-year-olds-in-a-high-resource-setting
#12
Elaine K McCarthy, Mairead E Kiely, Geraldine Hannon, Caroline Ahearne, Louise C Kenny, Jonathan O'B Hourihane, Alan D Irvine, Deirdre M Murray
Fe deficiency in early childhood is associated with long-term consequences for cognitive, motor and behavioural development; however explorations in healthy children from low risk, high-resource settings have been limited. We aimed to explore associations between Fe status and neurodevelopmental outcomes in low risk, healthy 2-year-olds. This study was a secondary analysis of a nested case-control subgroup from the prospective, maternal-infant Cork Babies after Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact using Neurological and Nutritional Endpoints (BASELINE) Birth Cohort Study...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28886240/a-review-of-diffusion-mri-of-typical-white-matter-development-from-early-childhood-to-young-adulthood
#13
Catherine Lebel, Sarah Treit, Christian Beaulieu
Understanding typical, healthy brain development provides a baseline from which to detect and characterize brain anomalies associated with various neurological or psychiatric disorders and diseases. Diffusion MRI is well suited to study white matter development, as it can virtually extract individual tracts and yield parameters that may reflect alterations in the underlying neural micro-structure (e.g. myelination, axon density, fiber coherence), though it is limited by its lack of specificity and other methodological concerns...
September 8, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28864240/global-motion-perception-is-associated-with-motor-function-in-2-year-old-children
#14
Benjamin Thompson, Christopher J D McKinlay, Arijit Chakraborty, Nicola S Anstice, Robert J Jacobs, Nabin Paudel, Tzu-Ying Yu, Judith M Ansell, Trecia A Wouldes, Jane E Harding
The dorsal visual processing stream that includes V1, motion sensitive area V5 and the posterior parietal lobe, supports visually guided motor function. Two recent studies have reported associations between global motion perception, a behavioural measure of processing in V5, and motor function in pre-school and school aged children. This indicates a relationship between visual and motor development and also supports the use of global motion perception to assess overall dorsal stream function in studies of human neurodevelopment...
September 29, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28858760/sex-differences-in-sensitivity-to-prenatal-and-early-childhood-manganese-exposure-on-neuromotor-function-in-adolescents
#15
Yueh-Hsiu Mathilda Chiu, Birgit Claus Henn, Hsiao-Hsien Leon Hsu, Mathew P Pendo, Brent A Coull, Christine Austin, Giuseppa Cagna, Chiara Fedrighi, Donatella Placidi, Donald R Smith, Robert O Wright, Roberto G Lucchini, Manish Arora
INTRODUCTION: While studies have suggested that exposure to manganese (Mn) may be associated with neurodevelopment in school-age children, there is limited information on prenatal and postnatal Mn exposures and tremor or motor function in children. METHODS: We measured Mn levels in dentine of shed teeth, representing prenatal, early postnatal, and cumulative childhood exposure windows, from 195 children (predominantly right-handed, 92%) in Italy. Pursuit Aiming, Luria Nebraska Motor Battery, as well as Tremor and Sway system from Computerized Adaptive Testing System (CATSYS) were administered at 11-14 years old...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28851784/the-effects-of-vitamin-b12-supplementation-in-pregnancy-and-postpartum-on-growth-and-neurodevelopment-in-early-childhood-study-protocol-for-a-randomized-placebo-controlled-trial
#16
Ram K Chandyo, Manjeswori Ulak, Ingrid Kvestad, Merina Shrestha, Suman Ranjitkar, Sudha Basnet, Mari Hysing, Laxman Shrestha, Tor A Strand
INTRODUCTION: Vitamin B12 is crucial for normal cell division and differentiation, and necessary for the development and myelination of the central nervous system. Pregnant mothers in resource poor settings are at risk for poor vitamin B12 status. Poor vitamin B12 status in infancy is linked to poor growth and neurodevelopment. Brain development starts from conception, and pregnancy is a period of rapid growth and development for the brain. METHODS AND ANALYSIS: The study is an individually randomised double-blind placebo controlled trial in 800 pregnant Nepalese women randomised in a 1:1 ratio...
August 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28827895/the-drosophila-foraging-gene-human-orthologue-prkg1-predicts-individual-differences-in-the-effects-of-early-adversity-on-maternal-sensitivity
#17
H Moriah Sokolowski, Oscar E Vasquez, Eva Unternaehrer, Dustin J Sokolowski, Stephanie D Biergans, Leslie Atkinson, Andrea Gonzalez, Patricia P Silveira, Robert Levitan, Kieran J O'Donnell, Meir Steiner, James Kennedy, Michael J Meaney, Alison S Fleming, Marla B Sokolowski
There is variation in the extent to which childhood adverse experience affects adult individual differences in maternal behavior. Genetic variation in the animal foraging gene, which encodes a cGMP-dependent protein kinase, contributes to variation in the responses of adult fruit flies, Drosophila melanogaster, to early life adversity and is also known to play a role in maternal behavior in social insects. Here we investigate genetic variation in the human foraging gene (PRKG1) as a predictor of individual differences in the effects of early adversity on maternal behavior in two cohorts...
April 2017: Cognitive Development
https://www.readbyqxmd.com/read/28822941/selenium-status-during-pregnancy-influential-factors-and-effects-on-neuropsychological-development-among-spanish-infants
#18
Rubén Amorós, Mario Murcia, Ferran Ballester, Karin Broberg, Carmen Iñiguez, Marisa Rebagliato, Helena Skröder, Llúcia González, Maria-Jose Lopez-Espinosa, Sabrina Llop
Selenium (Se) has been positively associated with neurodevelopment in early life. However, its margin of safety is rather narrow, and few prospective studies have evaluated its potential neurotoxic effects at intermediate levels. We aimed to explore the association between maternal Se concentrations and child neuropsychological development, including the genetic effect modification of the Se metabolizing gene INMT. Study subjects were 650 mother-child pairs from the Spanish Childhood and Environment Project (INMA, 2003-2005)...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28814550/changing-neurodevelopment-at-8-years-in-children-born-extremely-preterm-since-the-1990s
#19
Jeanie L Y Cheong, Peter J Anderson, Alice C Burnett, Gehan Roberts, Noni Davis, Leah Hickey, Elizabeth Carse, Lex W Doyle
BACKGROUND AND OBJECTIVE: Survival of extremely preterm (EP; <28 weeks' gestation) infants has increased over the last 2 decades. Equivalent reductions in developmental morbidity in early childhood have not been consistently reported. The aim of this study was to determine trends in neurodevelopmental outcomes at 8 years of age of children born EP (22-27 completed weeks' gestation) over the past 2 decades. METHODS: Population-based cohorts of all EP survivors born in the state of Victoria, Australia in 1991-1992, 1997, and 2005 were recruited at birth...
June 2017: Pediatrics
https://www.readbyqxmd.com/read/28750755/evening-salivary-cortisol-and-alpha-amylase-at-14months-and-neurodevelopment-at-4years-sex-differences
#20
Ainara Andiarena, Nekane Balluerka, Mario Murcia, Jesús Ibarluzea, Vivette Glover, Oscar Vegas
Stress system activity in early life can have long-term effects on neurodevelopment. The main aim of this study was to assess the association of child evening salivary cortisol and alpha-amylase basal levels at 14months of age with longer-term neuropsychological development at 4years in a low-risk population-based birth cohort derived from the INMA (Environment and Childhood) project in Spain. We included 186 parent-children pairs with information on both stress system activity and neurodevelopment. Both stress markers at 14months of age showed an association with neuropsychological development at 4years...
July 26, 2017: Hormones and Behavior
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