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Early childhood neurodevelopment

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https://www.readbyqxmd.com/read/28471442/an-antenatal-marker-of-neurodevelopmental-outcomes-in-infants-with-congenital-heart-disease
#1
S Siddiqui, W P Fifer, M Ordonez-Retamar, J D Nugent, I A Williams
OBJECTIVE: Prenatal exposures are known to alter fetal neurodevelopment and autonomic control. We aimed to explore the correlation between fetal autonomic activity, measured by fetal heart rate variability, and 18-month developmental outcome in subjects with congenital heart disease. STUDY DESIGN: From 2010 to 2013, 5 fetuses with hypoplastic left heart syndrome, 9 with transposition of the great arteries and 9 with tetralogy of Fallot were included in this prospective cohort study...
May 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28470384/first-60-fetal-in-utero-myelomeningocele-repairs-at-saint-louis-fetal-care-institute-in-the-post-moms-trial-era-hydrocephalus-treatment-outcomes-endoscopic-third-ventriculostomy-versus-ventriculo-peritoneal-shunt
#2
Samer K Elbabaa, Anne M Gildehaus, Matthew J Pierson, J Andrew Albers, Emanuel J Vlastos
INTRODUCTION: The published results of the Management of Myelomeningocele Study (MOMS) trial in 2011 showed improved outcomes (reduced need for shunting, decreased incidence of Chiari II malformation, and improved scores of mental development and motor function) in the fetal prenatal repair group compared to the postnatal group. Historically, endoscopic third ventriculostomy (ETV) remains as a controversial hydrocephalus treatment option with high failure rates in pediatric patients with a history of myelomeningocele (MMC)...
May 3, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28459271/maternal-posttraumatic-stress-disorder-and-infant-developmental-outcomes-in-a-south-african-birth-cohort-study
#3
Nastassja Koen, Kirsty Brittain, Kirsten A Donald, Whitney Barnett, Sheri Koopowitz, Karen Maré, Heather J Zar, Dan J Stein
OBJECTIVE: To investigate the association between maternal posttraumatic stress disorder (PTSD) and infant development in a South African birth cohort. METHOD: Data from the Drakenstein Child Health Study were analyzed. Maternal psychopathology was assessed using self-report and clinician-administered interviews; and 6-month infant development using the Bayley III Scales of Infant Development. Linear regression analyses explored associations between predictor and outcome variables...
May 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28444113/prenatal-exposure-to-fever-and-infections-and-academic-performance-a-multilevel-analysis
#4
Julie Werenberg Dreier, Gabriele Berg-Beckhoff, Per Kragh Andersen, Anne-Marie Nybo Andersen
Prenatal exposure to fever and infections has been linked to various neurodevelopmental disorders, but it is not yet known whether more subtle effects on neurodevelopment may exist as well. Therefore, we aimed to investigate whether these early-life exposures were associated with academic performance in childhood and early adolescence. Children and mothers who were enrolled in the Danish National Birth Cohort during 1996-2002 were included in this study. Information on fever and infections common in pregnancy was prospectively collected in 2 pregnancy interviews and linked with assessments of academic performance from the 2010-2013 Danish National Tests...
April 24, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28434427/prenatal-fish-oil-supplementation-and-early-childhood-development-in-the-upstate-kids-study
#5
K Vollet, A Ghassabian, R Sundaram, N Chahal, E H Yeung
Fish oil contains omega-3 fatty acids, which play a vital role in fetal growth and development. In utero exposure to omega-3 fatty acids is exclusively dependent on maternal nutrition. Previous studies have suggested that prenatal fish oil supplementation has positive impacts on child neurodevelopment later in life. This study examines the associations between fish oil supplementation both before pregnancy and throughout pregnancy and subsequent child development. Mother-child pairs from the Upstate KIDS Study, a birth cohort consisting of children born between 2008 and 2010, were included...
April 24, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28412445/methylphenidate-effects-in-the-young-brain-friend-or-foe
#6
REVIEW
Sara Loureiro-Vieira, Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. Despite the proven therapeutic efficacy, concerns have been raised regarding the possible consequences of chronic MPH exposure during childhood and adolescence. Disturbances in the neurodevelopment at these crucial stages are major concerns given the unknown future life consequences...
April 13, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28384542/gene-expression-in-blood-of-children-and-adolescents-mediation-between-childhood-maltreatment-and-major-depressive-disorder
#7
Leticia Maria Spindola, Pedro Mario Pan, Patricia Natalia Moretti, Vanessa Kiyomi Ota, Marcos Leite Santoro, Hugo Cogo-Moreira, Ary Gadelha, Giovanni Salum, Gisele Gus Manfro, Jair Jesus Mari, Helena Brentani, Rodrigo Grassi-Oliveira, Elisa Brietzke, Euripedes Constantino Miguel, Luis Augusto Rohde, João Ricardo Sato, Rodrigo Affonseca Bressan, Sintia Iole Belangero
Investigating major depressive disorder (MDD) in childhood and adolescence can help reveal the relative contributions of genetic and environmental factors to MDD, since early stages of disease have less influence of illness exposure. Thus, we investigated the mRNA expression of 12 genes related to the hypothalamic-pituitary-adrenal (HPA) axis, inflammation, neurodevelopment and neurotransmission in the blood of children and adolescents with MDD and tested whether a history of childhood maltreatment (CM) affects MDD through gene expression...
March 22, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28337648/diagnosis-and-treatment-of-alternating-hemiplegia-of-childhood
#8
REVIEW
Melanie Masoud, Lyndsey Prange, Jeffrey Wuchich, Arsen Hunanyan, Mohamad A Mikati
The diagnosis and treatment of patients with Alternating Hemiplegia of Childhood (AHC) and related disorders should be provided by a multidisciplinary team experienced with the spectrum of presentations of this disease, with its related disorders, with its complex and fluctuating manifestations, and with cutting edge advances occurring in the field. Involvement in research to advance the understanding of this disease and partnership with international collaborators and family organizations are also important...
February 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28327185/economic-evaluation-of-interventions-delivered-by-primary-care-providers-to-improve-neurodevelopment-in-children-aged-under-5%C3%A2-years-protocol-for-a-scoping-review
#9
Karen M Edmond, Natalie A Strobel, Kimberley McAuley, Elizabeth Geelhoed, Lisa Hurt
BACKGROUND: Frequently cited benefit-cost ratios suggest that interventions to improve neurodevelopment have high economic returns when implemented during pregnancy and early childhood. However, there are many challenges when primary care providers implement these interventions at scale, and it is unclear how many research studies or programmes have examined cost-effectiveness and which methods were used. There are no current scoping or systematic reviews which have assessed economic evaluations of interventions delivered by primary care providers to improve child neurodevelopment...
March 21, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28321847/antenatal-corticosteroids-for-accelerating-fetal-lung-maturation-for-women-at-risk-of-preterm-birth
#10
REVIEW
Devender Roberts, Julie Brown, Nancy Medley, Stuart R Dalziel
BACKGROUND: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28191550/mapping-lifetime-brain-volumetry-with-covariate-adjusted-restricted-cubic-spline-regression-from-cross-sectional-multi-site-mri
#11
Yuankai Huo, Katherine Aboud, Hakmook Kang, Laurie E Cutting, Bennett A Landman
Understanding brain volumetry is essential to understand neurodevelopment and disease. Historically, age-related changes have been studied in detail for specific age ranges (e.g., early childhood, teen, young adults, elderly, etc.) or more sparsely sampled for wider considerations of lifetime aging. Recent advancements in data sharing and robust processing have made available considerable quantities of brain images from normal, healthy volunteers. However, existing analysis approaches have had difficulty addressing (1) complex volumetric developments on the large cohort across the life time (e...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28109652/epilepsy-in-patients-with-grin2a-alterations-genetics-neurodevelopment-epileptic-phenotype-and-response-to-anticonvulsive-drugs
#12
C von Stülpnagel, M Ensslen, R S Møller, D K Pal, S Masnada, P Veggiotti, E Piazza, M Dreesmann, T Hartlieb, T Herberhold, E Hughes, M Koch, C Kutzer, K Hoertnagel, J Nitanda, M Pohl, K Rostásy, T B Haack, K Stöhr, G Kluger, I Borggraefe
OBJECTIVE: To delineate the genetic, neurodevelopmental and epileptic spectrum associated with GRIN2A alterations with emphasis on epilepsy treatment. METHODS: Retrospective study of 19 patients (7 females; age: 1-38 years; mean 10.1 years) with epilepsy and GRIN2A alteration. Genetic variants were classified according to the guidelines and recommendations of the American College of Medical Genetics (ACMG). Clinical findings including epilepsy classification, treatment, EEG findings, early childhood development and neurodevelopmental outcome were collected with an electronic questionnaire...
May 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28107388/factors-moderating-the-relationship-between-childhood-trauma-and-premorbid-adjustment-in-first-episode-schizophrenia
#13
S Kilian, J K Burns, S Seedat, L Asmal, B Chiliza, S Du Plessis, M R Olivier, M Kidd, R Emsley
Childhood trauma is a recognised risk factor for schizophrenia. It has been proposed that childhood trauma interferes with normal neurodevelopment, thereby establishing a biological vulnerability to schizophrenia. Poor premorbid adjustment is frequently a precursor to schizophrenia, and may be a manifestation of neurodevelopmental compromise. We investigated the relationship between childhood trauma and premorbid adjustment in 77 patients with first-episode schizophrenia spectrum disorders. We also investigated possible mediating roles for other selected risk factors in the relationship...
2017: PloS One
https://www.readbyqxmd.com/read/28100255/early-life-exposure-to-air-pollution-and-greater-use-of-academic-support-services-in-childhood-a-population-based-cohort-study-of-urban-children
#14
Jeanette A Stingone, Katharine H McVeigh, Luz Claudio
BACKGROUND: There is a growing literature showing associations between prenatal and early-life exposure to air pollution and children's neurodevelopment. However, it is unclear if decrements in neurodevelopment observed in epidemiologic research translate into observable functional outcomes in the broader pediatric population. The objective of this study was to examine the association between early-life exposures to common urban air toxics and the use of academic support services, such as early intervention and special education within a population-based cohort of urban children...
January 18, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28044047/parental-obesity-and-early-childhood-development
#15
Edwina H Yeung, Rajeshwari Sundaram, Akhgar Ghassabian, Yunlong Xie, Germaine Buck Louis
BACKGROUND: Previous studies identified associations between maternal obesity and childhood neurodevelopment, but few examined paternal obesity despite potentially distinct genetic/epigenetic effects related to developmental programming. METHODS: Upstate KIDS (2008-2010) recruited mothers from New York State (excluding New York City) at ∼4 months postpartum. Parents completed the Ages and Stages Questionnaire (ASQ) when their children were 4, 8, 12, 18, 24, 30, and 36 months of age corrected for gestation...
February 2017: Pediatrics
https://www.readbyqxmd.com/read/27882772/mirnas-differentially-expressed-by-next-generation-sequencing-in-cord-blood-buffy-coat-samples-of-boys-and-girls
#16
Daneida Lizarraga, Karen Huen, Mary Combs, Maria Escudero-Fung, Brenda Eskenazi, Nina Holland
AIM: Differences in children's development and susceptibility to diseases and exposures have been observed by sex, yet human studies of sex differences in miRNAs are limited. MATERIALS & METHODS: The genome-wide miRNA expression was characterized by sequencing-based EdgeSeq assay in cord blood buffy coats from 89 newborns, and 564 miRNAs were further analyzed. RESULTS: Differential expression of most miRNAs was higher in boys. Neurodevelopment, RNA metabolism and metabolic ontology terms were enriched among miRNA targets...
December 2016: Epigenomics
https://www.readbyqxmd.com/read/27873045/the-interplay-between-early-father-involvement-and-neonatal-medical-risk-in-the-prediction-of-infant-neurodevelopment
#17
Dylan B Jackson
The current study examines the association between early father involvement and infant neurodevelopment, and whether neonatal medical risk moderates this association. Data from approximately 6000 fathers and their children were obtained from the Early Childhood Longitudinal Study: Birth Cohort (ECLS-B). Hierarchical regression was employed to analyze the data. The findings reveal that the association between early father involvement and infant neurodevelopment is contingent on both the timing of involvement (i...
November 22, 2016: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/27857130/early-life-exposure-to-edcs-role-in-childhood-obesity-and-neurodevelopment
#18
REVIEW
Joseph M Braun
Endocrine-disrupting chemicals (EDCs) might increase the risk of childhood diseases by disrupting hormone-mediated processes that are critical for growth and development during gestation, infancy and childhood. The fetus, infant and child might have enhanced sensitivity to environmental stressors such as EDCs due to their rapid development and increased exposure to some EDCs as a consequence of development-specific behaviour, anatomy and physiology. In this Review, I discuss epidemiological studies examining the relationship between early-life exposure to bisphenol A (BPA), phthalates, triclosan and perfluoroalkyl substances (PFAS) with childhood neurobehavioural disorders and obesity...
March 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27809911/stunting-is-associated-with-blood-lead-concentration-among-bangladeshi-children-aged-2-3-years
#19
Kelsey M Gleason, Linda Valeri, A H Shankar, Md Omar Sharif Ibne Hasan, Quazi Quamruzzaman, Ema G Rodrigues, David C Christiani, Robert O Wright, David C Bellinger, Maitreyi Mazumdar
BACKGROUND: Lead toxicity is of particular public health concern given its near ubiquitous distribution in nature and established neurotoxicant properties. Similar in its ubiquity and ability to inhibit neurodevelopment, early childhood stunting affects an estimated 34 % of children under 5 in low- and middle-income countries. Both lead and stunting have been shown to be associated with decreased neurodevelopment, although the relationship between these childhood burdens is underexplored...
November 4, 2016: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/27798752/structural-brain-alterations-of-down-s-syndrome-in-early-childhood-evaluation-by-dti-and-volumetric-analyses
#20
Hediye Pınar Gunbey, Meltem Ceyhan Bilgici, Kerim Aslan, Arzu Ceylan Has, Methiye Gonul Ogur, Aslıhan Alhan, Lutfi Incesu
OBJECTIVES: To provide an initial assessment of white matter (WM) integrity with diffusion tensor imaging (DTI) and the accompanying volumetric changes in WM and grey matter (GM) through volumetric analyses of young children with Down's syndrome (DS). METHODS: Ten children with DS and eight healthy control subjects were included in the study. Tract-based spatial statistics (TBSS) were used in the DTI study for whole-brain voxelwise analysis of fractional anisotropy (FA) and mean diffusivity (MD) of WM...
October 31, 2016: European Radiology
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