Sanem P Uysal, Yadi Li, Nicolas R Thompson, Alex Milinovich, Justin R Abbatemarco, Jeffrey A Cohen, Devon S Conway, Daniel Ontaneda, John A Morren, Amy Kunchok
BACKGROUND: We aimed to investigate the prognostic factors associated with clinical outcomes in CV2/Collapsin response-mediator protein 5 (CRMP5)-IgG paraneoplastic neurologic disorders (PND). METHODS: This is a retrospective study of patients with CV2/CRMP5-IgG PND evaluated between 2002-2022. We examined the association of clinical variables (including age, clinical phenotype [autoimmune encephalopathy, myelopathy, polyneuropathy/radiculopathy, MG, cerebellar ataxia, chorea, optic neuropathy], cancer) with three clinical outcomes (wheelchair dependence, modified Rankin Scale [mRS], mortality) using univariate logistic regression and Cox proportional hazards modeling...
January 22, 2024: Annals of Clinical and Translational Neurology