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https://www.readbyqxmd.com/read/28742370/a-community-grows-around-the-geysering-world-of-enceladus
#1
Carolyn C Porco
The discovery by NASA's Cassini mission at Saturn in 2005 of a large plume of material erupting from the south polar terrain of Enceladus, sourced within a subsurface ocean of salty liquid water laced with organic compounds, has brought together scientists from a diverse range of disciplines over the last decade to evaluate this small moon's potential for extraterrestrial life. The collection of papers published today in Astrobiology, as the mission draws to a close, is the outcome of our most recent meeting at UC Berkeley in June 2016...
July 25, 2017: Astrobiology
https://www.readbyqxmd.com/read/28727859/space-flight-associated-neuro-ocular-syndrome
#2
Andrew G Lee, Thomas H Mader, C Robert Gibson, William Tarver
New and unique physiologic and pathologic systemic and neuro-ocular responses have been documented in astronauts during and after long-duration space flight. Although the precise cause remains unknown, space flight-associated neuro-ocular syndrome (SANS) has been adopted as an appropriate descriptive term. The Space Medicine Operations Division of the US National Aeronautics and Space Administration (NASA) has documented the variable occurrence of SANS in astronauts returning from long-duration space flight on the International Space Station...
July 20, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28726816/nasa-no-cost-crisis-for-space-telescope
#3
Thomas H Zurbuchen
No abstract text is available yet for this article.
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28720189/enhancing-the-meaningfulness-of-work-for-astronauts-on-long-duration-space-exploration-missions
#4
Thomas W Britt, Anton Sytine, Ashley Brady, Russ Wilkes, Rebecca Pittman, Kristen Jennings, Kandice Goguen
INTRODUCTION: Numerous authors have identified the stressors likely to be encountered on long duration space exploration missions (e.g., to Mars), including the possibility of significant crises, separation from family, boredom/monotony, and interpersonal conflict. Although many authors have noted that meaningful work may be beneficial for astronauts on these missions, none have detailed the sources of meaningful work for astronauts and how these sources may differ between astronauts...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28720182/ground-reaction-forces-during-reduced-gravity-running-in-parabolic-flight
#5
Peter Cavanagh, Andrea Rice, Molly Glauberman, Amanda Sudduth, Arien Cherones, Shane Davis, Michael Lewis, Andrea Hanson, Grier Wilt
BACKGROUND: Treadmills have been employed as both a form of exercise and a countermeasure to prevent changes in the musculoskeletal system on almost all NASA missions and many Russian missions since the early Space Shuttle flights. It is possible that treadmills may also be part of exercise programs on future Mars missions and that they may be a component of exercise facilities in lunar or Martian habitats. METHODS: In order to determine if the ambient gravity on these destinations will provide osteogenic effects while performing exercise on a treadmill, ground reactions forces (GRFs) were measured on eight subjects (six women and two men) running at 6 mph during parabolic flight in Martian and lunar gravity conditions...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28702783/origins-of-life-research-a-bibliometric-approach
#6
Arsev Umur Aydinoglu, Zehra Taşkın
This study explores the collaborative nature and interdisciplinarity of the origin(s) of life (OoL) research community. Although OoL research is one of the oldest topics in philosophy, religion, and science; to date there has been no review of the field utilizing bibliometric measures. A dataset of 5647 publications that are tagged as OoL, astrobiology, exobiology, and prebiotic chemistry is analyzed. The most prolific authors (Raulin, Ehrenfreund, McKay, Cleaves, Cockell, Lazcano, etc.), most cited scholars and their articles (Miller 1953, Gilbert 1986, Chyba & Sagan 1992, Wȁchtershȁuser 1988, etc...
July 13, 2017: Origins of Life and Evolution of the Biosphere
https://www.readbyqxmd.com/read/28686681/kir-and-their-hla-class-i-ligands-two-more-pieces-towards-completing-the-puzzle-of-chronic-rejection-and-graft-loss-in-kidney-transplantation
#7
Roberto Littera, Gianbenedetto Piredda, Davide Argiolas, Sara Lai, Elena Congeddu, Paola Ragatzu, Maurizio Melis, Elisabetta Carta, Maria Benigna Michittu, Donatella Valentini, Luisella Cappai, Rita Porcella, Francesco Alba, Maria Serra, Valentina Loi, Roberta Maddi, Sandro Orrù, Giorgio La Nasa, Giovanni Caocci, Roberto Cusano, Marcella Arras, Mauro Frongia, Antonello Pani, Carlo Carcassi
BACKGROUND: Kidney transplantation is a life-saving treatment for patients with end-stage renal disease. However, despite progress in surgical techniques and patient management, immunological rejection continues to have a negative impact on graft function and overall survival. Incompatibility between donors and recipients for human leukocyte antigens (HLA) of the major histocompatibility complex (MHC) generates a series of complex cellular and humoral immune response mechanisms that are largely responsible for rejection and loss of graft function...
2017: PloS One
https://www.readbyqxmd.com/read/28684476/nasa-armada-targets-thaw-in-arctic-soil
#8
Paul Voosen
No abstract text is available yet for this article.
July 7, 2017: Science
https://www.readbyqxmd.com/read/28679260/stability-of-sonic-boom-metrics-regarding-signature-distortions-from-atmospheric-turbulence
#9
William J Doebler, Victor W Sparrow
The degree of insensitivity to atmospheric turbulence was evaluated for five metrics (A-, B-, E-weighted sound exposure level, Stevens Mark VII Perceived Level, and NASA's Indoor Sonic Boom Annoyance Predictor) that correlate to human annoyance from sonic booms. Eight N-wave shaped sonic booms from NASA's FaINT experiment and five simulated "low-boom" sonic booms were turbulized by Locey's ten atmospheric filter functions. The B-weighted sound exposure level value changed the least due to the turbulence filters for twelve of thirteen booms...
June 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28678223/spatial-and-spectral-resolution-of-carbonaceous-material-from-hematite-%C3%AE-fe2o3-using-multivariate-curve-resolution-alternating-least-squares-mcr-als-with-raman-microspectroscopic-mapping-implications-for-the-search-for-life-on-mars
#10
Joseph P Smith, Frank C Smith, Karl S Booksh
The search for evidence of extant or past life on Mars is a primary objective of both the upcoming Mars 2020 rover (NASA) and ExoMars 2020 rover (ESA/Roscosmos) missions. This search will involve the detection and identification of organic molecules and/or carbonaceous material within the Martian surface environment. For the first time on a mission to Mars, the scientific payload for each rover will include a Raman spectrometer, an instrument well-suited for this search. Hematite (α-Fe2O3) is a widespread mineral on the Martian surface...
July 5, 2017: Analyst
https://www.readbyqxmd.com/read/28649632/three-dimensional-organotypic-co-culture-model-of-intestinal-epithelial-cells-and-macrophages-to-study-salmonella-enterica-colonization-patterns
#11
Jennifer Barrila, Jiseon Yang, Aurélie Crabbé, Shameema F Sarker, Yulong Liu, C Mark Ott, Mayra A Nelman-Gonzalez, Simon J Clemett, Seth D Nydam, Rebecca J Forsyth, Richard R Davis, Brian E Crucian, Heather Quiriarte, Kenneth L Roland, Karen Brenneman, Clarence Sams, Christine Loscher, Cheryl A Nickerson
Three-dimensional models of human intestinal epithelium mimic the differentiated form and function of parental tissues often not exhibited by two-dimensional monolayers and respond to Salmonella in key ways that reflect in vivo infections. To further enhance the physiological relevance of three-dimensional models to more closely approximate in vivo intestinal microenvironments encountered by Salmonella, we developed and validated a novel three-dimensional co-culture infection model of colonic epithelial cells and macrophages using the NASA Rotating Wall Vessel bioreactor...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649629/rhogtpase-stimulation-is-associated-with-strontium-chloride-treatment-to-counter-simulated-microgravity-induced-changes-in-multipotent-cell-commitment
#12
Fiona Louis, Wafa Bouleftour, Aline Rattner, Marie-Thérèse Linossier, Laurence Vico, Alain Guignandon
Microgravity-related cytoskeletal disorganization is associated with an altered balance between osteoblastogenesis and adipogenesis of multipotent cells. Strontium chloride is known to increase osteoblastogenesis and repress adipogenesis, but its effects in microgravity-related conditions have not been established. Our goal was to investigate early events in this process, focusing on RhoGTPases as controllers of cytoskeletal organization leading to stem cell commitment. We cultivated C3H10T1/2 on microspheres using a rotating wall vessel bioreactor (NASA) in order to simulate microgravity-related conditions in adipogenesis and osteoblastogenesis conditions independently...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28649627/from-the-bench-to-exploration-medicine-nasa-life-sciences-translational-research-for-human-exploration-and-habitation-missions
#13
Joshua S Alwood, April E Ronca, Richard C Mains, Mark J Shelhamer, Jeffrey D Smith, Thomas J Goodwin
NASA's Space Biology and Human Research Program entities have recently spearheaded communications both internally and externally to coordinate the agency's translational research efforts. In this paper, we strongly advocate for translational research at NASA, provide recent examples of NASA sponsored early-stage translational research, and discuss options for a path forward. Our overall objective is to help in stimulating a collaborative research across multiple disciplines and entities that, working together, will more effectively and more rapidly achieve NASA's goals for human spaceflight...
2017: NPJ Microgravity
https://www.readbyqxmd.com/read/28641885/remote-sensing-and-water-quality-indicators-in-the-korean-west-coast-spatio-temporal-structures-of-modis-derived-chlorophyll-a-and-total-suspended-solids
#14
Hae-Cheol Kim, Seunghyun Son, Yong Hoon Kim, Jong Seong Khim, Jungho Nam, Won Keun Chang, Jung-Ho Lee, Chang-Hee Lee, Jongseong Ryu
The Yellow Sea is a shallow marginal sea with a large tidal range. In this study, ten areas located along the western coast of the Korean Peninsula are investigated with respect to remotely sensed water quality indicators derived from NASA MODIS aboard of the satellite Aqua. We found that there was a strong seasonal trend with spatial heterogeneity. In specific, a strong six-month phase-lag was found between chlorophyll-a and total suspended solid owing to their inversed seasonality, which could be explained by different dynamics and environmental settings...
June 19, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28641680/ophthalmological-evaluation-of-integrated-resistance-and-aerobic-training-during-70-day-bed-rest
#15
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28637602/perceived-task-complexity-of-trunk-stability-exercises
#16
Megan McPhee, Kylie J Tucker, Alan Wan, David A MacDonald
BACKGROUND: Perceived task complexity can impact participation in an exercise programme and the level of skill acquisition resulting from participation. Although trunk stability exercises are commonly included in the management of people with low back pain, potential differences in perceived task complexity between those exercises have not been investigated previously. OBJECTIVE: To investigate the perceived task complexity following first time instruction of two common stability exercises: the abdominal brace and abdominal hollow...
February 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28627727/development-of-hgf-binding-aptamers-with-the-combination-of-g4-promoter-derived-aptamer-selection-and-in-silico-maturation
#17
Tomomi Yokoyama, Kaori Tsukakoshi, Wataru Yoshida, Taiki Saito, Kentaro Teramoto, Nasa Savory, Koichi Abe, Kazunori Ikebukuro
We describe the selection of aptamers based on bioinformatics-based approaches without Systematic Evolution of Ligands by EXponential enrichment (SELEX). SELEX is a potent method; however, it is time intensive and the PCR-amplification step, which is essential step for SELEX, leads to the loss of good aptamers. We have developed an aptamer-screening method, G4 promoter-derived aptamer selection (G4PAS), and an aptamer-improving method, in silico maturation (ISM). They are based on in silico sequence selection and computer assisted directed evolution, respectively...
June 19, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28625820/the-effect-of-economic-downturn-on-the-volume-of-surgical-procedures-a-systematic-review
#18
REVIEW
Nasa Fujihara, Meghan E Lark, Yuki Fujihara, Kevin C Chung
BACKGROUND: Economic downturn can have a wide range of effects on medicine at both individual and national levels. We aim to describe these effects in relation to surgical volume to guide future planning for physician specialization, patient expectations in the face of economic crises, or estimating healthcare expenditure. We hypothesized that because of high out-of-pocket costs, cosmetic procedure volumes would be most affected by economic decline. METHODS: A systematic review was conducted using MEDLINE, Embase, and ABI/INFORMS...
June 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28624991/a-new-global-and-comprehensive-model-for-icu-ventilator-performances-evaluation
#19
Nicolas S Marjanovic, Agathe De Simone, Guillaume Jegou, Erwan L'Her
BACKGROUND: This study aimed to provide a new global and comprehensive evaluation of recent ICU ventilators taking into account both technical performances and ergonomics. METHODS: Six recent ICU ventilators were evaluated. Technical performances were assessed under two FIO2 levels (100%, 50%), three respiratory mechanics combinations (Normal: compliance [C] = 70 mL cmH2O(-1)/resistance [R] = 5 cmH2O L(-1) s(-1); Restrictive: C = 30/R = 10; Obstructive: C = 120/R = 20), four exponential levels of leaks (from 0 to 12...
December 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28601115/modeling-change-in-project-duration-and-completion-scheduling-dynamics-of-nasa-s-exploration-flight-test-1-eft-1-activities
#20
Travis J Wiltshire, Jonathan E Butner, Zachary Pirtle
In complex work domains and organizations, understanding schedule-ing dynamics can ensure objectives are reached and delays are mitigated. In the current paper, we examine the scheduling dynamics for NASA's Exploration Flight Test 1 (EFT-1) activities. For this examination, we specifically modeled simultaneous change in percent complete and estimated duration for a given project as they were included in monthly reports over time. In short, we utilized latent change score mixture modeling to extract the attractor dynamics within the scheduling data...
July 2017: Nonlinear Dynamics, Psychology, and Life Sciences
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