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https://www.readbyqxmd.com/read/28512561/bone-marrow-homing-and-engraftment-defects-of-human-hematopoietic-stem-and-progenitor-cells
#1
REVIEW
Giovanni Caocci, Marianna Greco, Giorgio La Nasa
Homing of hematopoietic stem cells (HSC) to their microenvironment niches in the bone marrow is a complex process with a critical role in repopulation of the bone marrow after transplantation. This active process allows for migration of HSC from peripheral blood and their successful anchoring in bone marrow before proliferation. The process of engraftment starts with the onset of proliferation and must, therefore, be functionally dissociated from the former process. In this overview, we analyze the characteristics of stem cells (SCs) with particular emphasis on their plasticity and ability to find their way home to the bone marrow...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28473544/nasa-pushes-for-diversity-in-planetary-science
#2
Paul Voosen
No abstract text is available yet for this article.
May 5, 2017: Science
https://www.readbyqxmd.com/read/28467513/relationship-between-workload-and-mind-wandering-in-simulated-driving
#3
Yuyu Zhang, Takatsune Kumada
Mental workload and mind-wandering are highly related to driving safety. This study investigated the relationship between mental workload and mind-wandering while driving. Participants (N = 40) were asked to perform a car following task in driving simulator, and report whether they had experienced mind-wandering upon hearing a tone. After driving, participants reported their workload using the NASA-Task Load Index (TLX). Results revealed an interaction between workload and mind-wandering in two different perspectives...
2017: PloS One
https://www.readbyqxmd.com/read/28462896/improving-radiation-oncology-providers-workload-and-performance-can-simulation-based-training-help
#4
Lukasz M Mazur, Prithima R Mosaly, Gregg Tracton, Marjorie P Stiegler, Robert D Adams, Bhishamjit S Chera, Lawrence B Marks
PURPOSE: To help with ongoing safety challenges in radiation therapy (RT), the objective of this research was to develop and assess the impact of a simulation-based training intervention on radiation oncology providers' workload and performance during treatment planning and quality assurance (QA) tasks. METHODS AND MATERIALS: Eighteen radiation oncology professionals completed routine treatment planning and QA tasks on 2 clinical scenarios in a simulation laboratory as part of a prospective institutional review board-approved study...
February 17, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28457047/plummer-vinson-syndrome-with-simultaneous-mid-esophageal-growth
#5
Mukesh Nasa, Gaurav Patil, Zubin Sharma, Rajesh Puri
Patterson Brown Kelly or Plummer-Vinson syndrome is characterized by dysphagia, iron deficiency anemia and post-cricoidal esophageal web. Waldenstorm introduced the term 'sideropenic dysphagia' because of absence of stainable iron in the bone marrow. There is increased incidence of upper aero-digestive tract carcinoma in patients with Plummer-Vinson syndrome has been well established. The reported rates range from 4% to 16%, with almost all cases occurring at the postcricoid location.We have reported here a case of a 48-year-old woman with dysphagia , upper esophageal web and iron deficiency anemia ...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28457046/gastrointestinal-histoplasmosis-and-cmv-co-infection-in-an-immunocompetent-host
#6
Mukesh Nasa, Nisharg Patel, Lipika Lipi, Randhir Sud
A middle aged male with no known comorbidities presented with history of colicky abdominal pain, low grade fever and weight loss. Laboratory parameters were normal except low albumin. Imaging showed multiple areas of mural thickening with enhancement in jejunum & ileum. On Colonoscopy there was a thickened and deformed ileum with multiple ulcers. The biopsy showed co-infection of CMV and histoplasma, urine antigen for histoplasma was positive and CMV DNA detected in blood. He was successfully treated with combination of Valgancyclovir and Amphotericin-B followed by itraconazole...
February 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28447482/quantitative-potassium-measurements-with-laser-induced-breakdown-spectroscopy-using-low-energy-lasers-application-to-in-situ-k-ar-geochronology-for-planetary-exploration
#7
Yuichiro Cho, Misa Horiuchi, Kazuo Shibasaki, Shingo Kameda, Seiji Sugita
In situ radiogenic isotope measurements to obtain the absolute age of geologic events on planets are of great scientific value. In particular, K-Ar isochrons are useful because of their relatively high technical readiness and high accuracy. Because this isochron method involves spot-by-spot K measurements using laser-induced breakdown spectroscopy (LIBS) and simultaneous Ar measurements with mass spectrometry, LIBS measurements are conducted under a high vacuum condition in which emission intensity decreases significantly...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28437992/a-large-airborne-survey-of-earth-s-visible-infrared-spectral-dimensionality
#8
David R Thompson, Joseph W Boardman, Michael L Eastwood, Robert O Green
The intrinsic spectral dimensionality indicates the observable degrees of freedom in Earth's solar-reflected light field, quantifying the diversity of spectral content accessible by visible and infrared remote sensing. The solar-reflected regime spans the 0.38 - 2.5 μm interval, and is captured by a wide range of current and planned instruments on both airborne and orbital platforms. To date there has been no systematic study of its spectral dimensionality as a function of space, time, and land cover. Here we report a multi-site, multi-year statistical survey by NASA's "Classic" Airborne Visible Near InfraRed Spectrometer (AVIRIS-C)...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437922/from-toes-to-top-of-atmosphere-fowler-s-sneaker-depth-index-of-water-clarity-for-the-chesapeake-bay
#9
Benjamin Crooke, Lachlan I W McKinna, Ivona Cetinić
Fowler's Sneaker Depth (FSD), analogous to the well known Secchi disk depth (Zsd), is a visually discerned citizen scientist metric used to assess water clarity in the Patuxent River estuary. In this study, a simple remote sensing algorithm was developed to derive FSD from space-borne spectroradiometric imagery. An empirical model was formed that estimates FSD from red-end remote sensing reflectances at 645 nm, Rrs(645). The model is based on a hyperbolic function relating water clarity to Rrs(645) that was established using radiative transfer modeling and fine tuned using in-water FSD measurements and coincident Rrs(645) data observed by NASA's Moderate Resolution Imaging Spectroradiometer aboard the Aqua spacecraft (MODISA)...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28417839/mortality-due-to-cardiovascular-disease-among-apollo-lunar-astronauts
#10
Robert J Reynolds, Steven M Day
INTRODUCTION: Recent research has postulated increased cardiovascular mortality for astronauts who participated in the Apollo lunar missions. The conclusions, however, are based on small numbers of astronauts, are derived from methods with known weaknesses, and are not consistent with prior research. METHODS: Records for NASA astronauts and U.S. Air Force astronauts were analyzed to produce standardized mortality ratios. Lunar astronauts were compared to astronauts who have never flown in space (nonflight astronauts), those who have only flown missions in low Earth orbit (LEO astronauts), and the U...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28417837/flight-crew-workload-evaluation-based-on-the-workload-function-distribution-method
#11
Yiyuan Zheng, Yanyu Lu, Yuwen Jie, Shan Fu
BACKGROUND: The minimum flight crew on the flight deck should be established according to the workload for individual crewmembers. Typical workload measures consist of three types: subjective rating scale, task performance, and psychophysiological measures. However, all these measures have their own limitations. To reflect flight crew workload more specifically and comprehensively within the flight environment, and more directly comply with airworthiness regulations, the Workload Function Distribution Method, which combined the basic six workload functions, was proposed...
May 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28412874/effects-of-regulatory-support-services-on-institutional-review-board-turnaround-times
#12
Pankaja Desai, Priyanka Nasa, Jackie Soo, Cunhui Jia, Michael L Berbaum, James H Fischer, Timothy P Johnson
We evaluated how regulatory support services provided by University of Illinois at Chicago's Center for Clinical and Translational Science may reduce Institutional Review Board (IRB) turnaround times. IRB applications were categorized by receipt of any regulatory support and amount of support received. Turnaround time included total turnaround time, time for IRB review, and time for investigators to modify protocols. There were no differences in any turnaround times for supported versus nonsupported applications...
April 1, 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28411723/fatigue-of-chinese-railway-employees-and-its-influential-factors-structural-equation-modelling
#13
Liuxing Tsao, Jing Chang, Liang Ma
Fatigue is an identifiable and preventable cause of accidents in transport operations. Regarding the railway sector, incident logs and simulation studies show that employee fatigue leads to lack of alertness, impaired performance, and occurrence of incidents. China has one of the largest rail systems in the world, and Chinese railway employees work under high fatigue risks; therefore, it is important to assess their fatigue level and find the major factors leading to fatigue. We designed a questionnaire that uses Multidimensional Fatigue Instrument (MFI-20), NASA-TLX and subjective rating of work overtime feelings to assess employee fatigue...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28410696/isolated-splenic-tuberculosis-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration
#14
Mukesh Nasa, Narendra S Choudhary, Mridula Guleria, Rajesh Puri
Our patient was a 48-year-old female, who presented with history of persistent low-grade fever and weight loss. The CT scan of the abdomen revealed multiple hypodense lesions in spleen. No primary focus of infection was detected in any other organs. Endoscopic ultrasound-guided fine needle aspiration of splenic lesion revealed granulomatous inflammation. The patient was started on anti-tuberculous therapy. There is a diagnostic possibility of splenic tuberculosis even in immunocompetent individuals and we chose a combination anti-tuberculous therapy as the first line treatment with consideration of splenectomy depending on the response...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28402154/glucose-6-phosphate-dehydrogenase-deficiency-and-risk-of-invasive-fungal-disease-in-patients-with-acute-myeloid-leukemia
#15
Marco Sanna, Giovanni Caocci, Antonio Ledda, Federica Orrù, Claudio Fozza, Paola Deias, Gianni Tidore, Fausto Dore, Giorgio La Nasa
Invasive fungal diseases (IFD) are still a leading cause of morbidity and mortality in patients with acute myeloid leukemia (AML). Glucose-6-phosphate dehydrogenase is an enzyme that leads to the production of NADPH, required to destroy microorganisms in the respiratory burst reaction of white blood cells. We evaluated the role of G6PD deficiency in susceptibility of IFD in 108 AML patients undergoing intensive chemotherapy. In all, 28 patients harbored G6PD deficiency (G6PD-), whereas 80 were normal (G6PD +)...
April 12, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28399040/a-new-enzyme-linked-immunosorbent-assay-for-a-total-anti-t-lymphocyte-globulin-determination-development-analytical-validation-and-clinical-applications
#16
Michela Montagna, Giorgio La Nasa, Maria E Bernardo, Eugenia Piras, Maria A Avanzini, Mario Regazzi, Franco Locatelli
BACKGROUND: Anti-T lymphocyte globulin (ATLG) modulates the alloreactivity of T lymphocytes, reducing the risk of immunological posttransplant complications, in particular rejection and graft-versus-host disease, after allogeneic hematopoietic stem cell transplantation (HSCT). We developed and validated a new enzyme-linked immunosorbent assay (ELISA) method to measure serum levels of total ATLG and evaluate the pharmacokinetics (PK) of the drug in children with β-Thalassemia, receiving allogeneic HSCT...
June 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28397781/measurement-of-the-cosmic-optical-background-using-the-long-range-reconnaissance-imager-on-new-horizons
#17
Michael Zemcov, Poppy Immel, Chi Nguyen, Asantha Cooray, Carey M Lisse, Andrew R Poppe
The cosmic optical background is an important observable that constrains energy production in stars and more exotic physical processes in the universe, and provides a crucial cosmological benchmark against which to judge theories of structure formation. Measurement of the absolute brightness of this background is complicated by local foregrounds like the Earth's atmosphere and sunlight reflected from local interplanetary dust, and large discrepancies in the inferred brightness of the optical background have resulted...
April 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/28383903/pressure-dependent-rate-rules-for-intramolecular-h-migration-reactions-of-hydroperoxyalkylperoxy-radicals-in-low-temperature
#18
Qian Yao, Xiao-Hui Sun, Ze-Rong Li, Fang-Fang Chen, Xiang-Yuan Li
Intramolecular H-migration reaction of hydroperoxyalkylperoxy radicals ((•)O2QOOH) is one of the most important reaction families in the low-temperature oxidation of hydrocarbon fuels. This reaction family is first divided into classes depending upon H atom transfer from -OOH bonded carbon or non-OOH bonded carbon, and then the two classes are further divided depending upon the ring size of the transition states and the types of the carbons from which the H atom is transferred. High pressure limit rate rules and pressure-dependent rate rules for each class are derived from the rate constants of a representative set of reactions within each class using electronic structure calculations performed at the CBS-QB3 level of theory...
April 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28380959/revisiting-short-wave-infrared-swir-bands-for-atmospheric-correction-in-coastal-waters
#19
Nima Pahlevan, Jean-Claude Roger, Ziauddin Ahmad
The shortwave infrared (SWIR) bands on the existing Earth Observing missions like MODIS have been designed to meet land and atmospheric science requirements. The future geostationary and polar-orbiting ocean color missions, however, require highly sensitive SWIR bands (> 1550nm) to allow for a precise removal of aerosol contributions. This will allow for reasonable retrievals of the remote sensing reflectance (R<sub>rs</sub>) using standard NASA atmospheric corrections over turbid coastal waters...
March 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28380263/estimating-the-probability-of-human-error-by-incorporating-component-failure-data-from-user-induced-defects-in-the-development-of-complex-electrical-systems
#20
Peter J Majewicz, Paul Blessner, Bill Olson, Timothy Blackburn
This article proposes a methodology for incorporating electrical component failure data into the human error assessment and reduction technique (HEART) for estimating human error probabilities (HEPs). The existing HEART method contains factors known as error-producing conditions (EPCs) that adjust a generic HEP to a more specific situation being assessed. The selection and proportioning of these EPCs are at the discretion of an assessor, and are therefore subject to the assessor's experience and potential bias...
April 5, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
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