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Sang Bum Kim, John M Rhee, Byung Hak Oh, You Gun Won, Yousun Jung, Kun Young Park, William C Hutton, Chulmin Kim
STUDY DESIGN: Cadaveric OBJECTIVE.: Determine optimal fluoroscopic views for detecting cervical lateral mass screw (LMS) violations SUMMARY OF BACKGROUND DATA.: Single plane intraoperative xrays are commonly used but frequently inadequate due to its complex trajectory. Fluoroscopy can be taken in multiple planes, but the ideal fluoroscopic view to assess malposition is not known: depending on the view, any given screw may look "in" or "out". METHODS: C3-6 LMS were inserted in 3 cadavers...
December 2, 2016: Spine
Alexis Gerber, Catriona Moynihan, Sharon Klim, Peter Ritchie, Anne-Maree Kelly
INTRODUCTION: Bundles of care are gaining popularity for treating acute severe illness. OBJECTIVE: To describe compliance with bundle of care elements (individually and as a 'bundle') for patients treated for chronic obstructive pulmonary disease (COPD) exacerbations in the emergency department (ED). METHODS: Retrospective observational study of patients presenting in the 2014 calendar year with an ED diagnosis of COPD. The primary outcomes of interest were compliance with key bundle of care elements (individually and as a 'bundle')...
November 18, 2016: Clinical Respiratory Journal
Mario Castro, Marcos Goycoolea, Verónica Silva-Pinto
CONCLUSIONS: External ear canal exostosis is more prevalent in northern coastal groups than in the highlands, suggesting that ocean activities facilitate the appearance of exostosis. However, southern coastal groups exposed to colder ocean water have a lesser incidence of exostosis, possibly due to less duration of exposure. There was a high incidence of otitis media in all groups of native population in Chile. One coastal group had a higher incidence, presumably due to racial factors...
November 11, 2016: Acta Oto-laryngologica
Paul L Aparicio, Elias Issa, James J DiCarlo
: While early cortical visual areas contain fine scale spatial organization of neuronal properties such as orientation preference, the spatial organization of higher-level visual areas is less well understood. The fMRI demonstration of face preferring regions in human ventral cortex (FFA, OFA) and monkey inferior temporal cortex ("face patches") raises the question of how neural selectivity for faces is organized. Here, we targeted hundreds of spatially registered neural recordings to the largest fMRI-identified face selective region in monkeys, the middle face patch (MFP) and show that the MFP contains a graded enrichment of face preferring neurons...
November 3, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Maddibande Ramachar Sreevathsa, Khyati Melanta
INTRODUCTION: The most common cause of gas under diaphragm is hollow viscous perforation. In 10% of cases it can be due to rare causes, both abdominal and extra-abdominal, one of them being intra abdominal infection by gas forming organisms. PRESENTATION OF THE CASE: A 51 year old male patient, a poorly controlled diabetic, presented with a second episode of severe pain abdomen and abdominal distention, with lower abdominal tenderness. Plain Xray of the abdomen in erect posture showed gas under the right dome of diaphragm and ultrasound abdomen confirmed gross pneumoperitoneum...
October 14, 2016: International Journal of Surgery Case Reports
M Telegrafo, T Introna, L Coi, I Cornacchia, L Rella, A A Stabile Ianora, G Angelelli, M Moschetta
AIM: To assess the role of breast US in diagnosing and classifying gynecomastia as the primary imaging modality and to compare US findings and classification system with the mammographic ones. PATIENTS AND METHODS: 48 patients suspected of having gynecomastia underwent mammography and US. Two radiologists in consensus retrospectively evaluated mammograms and sonograms. Both US and mammographic images were evaluated categorizing gynecomastia into non-mass, nodular and flame shaped patterns...
May 2016: Il Giornale di Chirurgia
Narges Labibzadeh, Mohsen Emadedin, Roghayeh Fazeli, Fatemeh Mohseni, Seyedeh Esmat Hosseini, Reza Moghadasali, Soura Mardpour, Vajiheh Azimian, Maede Ghorbani Liastani, Ali Mirazimi Bafghi, Mohamadreza Baghaban Eslaminejad, Nasser Aghdami
OBJECTIVE: Nonunion is defined as a minimum of 9 months since injury without any visible progressive signs of healing for 3 months. Recent literature has shown that the application of mesenchymal stromal cells is safe, in vitro and in vivo, for treating long bone nonunion. The present study was performed to investigate the safety of mesenchymal stromal cell (MSC) implantation in combination with platelet lysate (PL) product for treating human long bone nonunion. MATERIALS AND METHODS: In this case series clinical trial, orthopedic surgeons visited eighteen patients with long bone nonunion, of whom 7 complied with the eligibility criteria...
2016: Cell Journal
Guangli Wang, Yuan Liu
Diazinon is a widely used organophosphorus insecticide often detected in the environment. A highly effective diazinon-degrading Ralstonia sp. strain DI-3 was isolated from agricultural soil. Strain DI-3 can utilize dimethoate as its sole carbon source for growth and degrade an initial concentration of 100 mg L-1 diazinon to non-detectable levels within 60 h in liquid culture. A small amount of second carbon source as co-substrate could slightly enhance the biodegradation of diazinon. In addition, a less toxic metabolic intermediate formed during the degradation of diazinon mediated by strain DI-3 was purified using thin-layer chromatography (TLC) and identified based on single-crystal Xray diffraction analysis, allowing a degradation pathway for diazinon by pure culture to be proposed...
September 2016: Journal of Biosciences
Richard Bostelmann, Tamara Bostelmann, Adrian Nasaca, Hans Jakob Steiger, Frank Zaucke, Christoph Schleich
BACKGROUND CONTEXT: On a molecular level, maturation or degeneration of human intervertebral disc is among others expressed by the content of glycosaminoglycans (GAGs). According to the degenerative status, the disc content can differ in nucleus pulposus (NP) and annulus fibrosus (AF), respectively. Research in this area was conducted mostly on postmortem samples. Although several radiological classification systems exist, none includes biochemical features. Therefore, we focused our in vivo study on a widely spread and less expensive imaging technique for the cervical spine and the correlation of radiological patterns to biochemical equivalents in the intervertebral discs...
August 25, 2016: Spine Journal: Official Journal of the North American Spine Society
Benjamin M Mervak, Matthew S Davenport, Kelsey A Flynt, Ella A Kazerooni, William J Weadock
PURPOSE: With the development of patient portals, the opportunity exists to identify gaps in practice by analyzing priorities patients place on the receipt and comprehension of radiology reports. Our purpose was to describe the nature of radiology-specific patient information requests by analysis of patient-initiated messages submitted through a web-based electronic patient portal. METHODS: Institutional review board approval was obtained and informed consent waived for this HIPAA-compliant retrospective cross-sectional study...
July 19, 2016: Journal of the American College of Radiology: JACR
Quentin Vallet, Nicolas Bochud, Christine Chappard, Pascal Laugier, Jean-Gabriel Minonzio
Cortical bone loss is not fully assessed by current Xray methods, and there is an unmet need in identifying women at risk of osteoporotic fracture who should receive a treatment. The last decade has seen the emergence of ultrasound axial transmission techniques to assess cortical bone. Recent axial transmission techniques exploit the multimode waveguide response of long bones such as the radius. A recent ex vivo study by our group evidenced that a multimode axial transmission approach can yield simultaneous estimates of cortical thickness and stiffness...
July 7, 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Maryam Mobini, Leyla Dehghan, Gholamali Yosefi, Alireza Mohammadpour, Rohollah Abdi
BACKGROUND: Bisphosphonates (BPs) are used extensively for managing the osteoporosis. There are some controversies on atypical fractures of femur that associated with increase in cortical thickness (CT) and BPs' use. In this study, the effects of alendronate consumption were studied on femoral CT as a predictor for atypical fracture. METHODS: Forty nine post-menopausal women aged 50-70 years with osteopenia-osteoporosis who were treated with alendronate 70 mg/week for at least one year were compared to 49 controls for CT in subtrochanteric region of femur by hip dual-energy X-ray absorptiometry (DXA) scans and hip Xray...
2016: Medical Journal of the Islamic Republic of Iran
Zahra Ouaray, Karim M ElSawy, David P Lane, Jonathan W Essex, Chandra Verma
Most p53 mutations associated with cancer are located in its DNA binding domain (DBD). Many structures (X-ray and NMR) of this domain are available in the protein data bank (PDB) and a vast conformational heterogeneity characterizes the various free and complexed states. The major difference between the apo and the holo-complexed states appears to lie in the L1 loop. In particular, the conformations of this loop appear to depend intimately on the sequence of DNA to which it binds. This conclusion builds upon recent observations that implicate the tetramerization and the C-terminal domains (respectively TD and Cter) in DNA binding specificity...
October 2016: Proteins
Iris Mangas, Jorge Estevez, Eugenio Vilanova, Tanos Celmar Costa França
Organophosphorus compounds (OPs) are a large and diverse class of chemicals mainly used as pesticides and chemical weapons. People may be exposed to OPs in several occasions, which can produce several distinct neurotoxic effects depending on the dose, frequency of exposure, type of OP, and the host factors that influence susceptibility and sensitivity. These neurotoxic effects are mainly due to the interaction with enzyme targets involved in toxicological or detoxication pathways. In this work, the toxicological relevance of known OPs targets is reviewed...
June 13, 2016: Toxicology
Andrew J Inglis, Marek Nalos, Kwan-Hing Sue, Jan Hruby, Daniel M Campbell, Rachel M Braham, Sam R Orde
OBJECTIVE: To compare lung ultrasonography (LUS), chest xray (CXR) and physical examination (Ex) for the detection of pathological abnormalities in the lungs of critically ill patients. DESIGN, SETTING AND PARTICIPANTS: A prospective cohort study of 145 patients in the intensive care unit of a tertiary teaching hospital who were undergoing echocardiography for a clinical indication. MAIN OUTCOME MEASURES: Each patient was independently assessed by Ex, CXR and LUS on the same day...
June 2016: Critical Care and Resuscitation: Journal of the Australasian Academy of Critical Care Medicine
Manolo Piccirilli, Chiara Liberati, Giorgio Santoro, Antonio Santoro
STUDY DESIGN: Radiographic and clinical analysis. OBJECTIVE: Review author's experience with anterior discectomy, interbody fusion, and anterior cervical plating in 33 patients with posttraumatic unilateral cervical locked facets. SUMMARY OF BACKGROUND DATA: Unilateral cervical locked facet syndrome is a relatively uncommon injury that often is misdiagnosed and therefore subject to a dangerous delay in surgery. Management of this trauma is controversial...
July 2016: Clinical Spine Surgery
Surjit Singh, Dhrubajyoti Sharma, Deepti Suri, Anju Gupta, Amit Rawat, Manoj Kumar Rohit
This was a single-centre study to evaluate the usefulness of tumour necrosis factor-α (TNF-α) blocker, infliximab (IFX), for treatment of Kawasaki disease (KD) in children in Northern Indian. The study was carried out in the Paediatric Allergy-Immunology Unit, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh. The study period was January 2007 to March 2015. Review of records of 23 children with KD who had received IFX was carried out. Median age at presentation was 2 years (range 2 months to 12 years)...
May 2016: Clinical and Experimental Rheumatology
Caroline Mahon, Wendy Walker, Alan Drage, Emma Best
AIM: To document rising incidence rates of childhood empyema and parapneumonic effusion (PPE) in South Auckland, New Zealand between 1998 and 2012; to compare epidemiology, pathogens and outcomes of children with empyema and PPE; and to ascertain whether primary care antibiotic prescribing, delayed presentation, or bacterial epidemiology might account for the rising incident rates. METHODS: Children aged 0 to14 years hospitalised with pleural empyema or PPE were retrospectively identified...
June 2016: Journal of Paediatrics and Child Health
Simel Ayyıldız, Elif Hilal Soylu, Jülide Özen, Semra İde, Kıvanç Kamburoğlu
OBJECTIVES: This study aimed to compare a number of new nano-composites capable of protecting the jaw from ionizing radiation. MATERIALS AND METHODS: Four different types of nano-powders [Ti, Zr (IV) oxide, Ag and Co] were mixed in a polymer matrix to create nano-composites with doping values of 8% in weight. Small-angle X-ray scattering (SAXS) analysis was performed using a HECUSSAXS system with 50 kV- 50 mA. Co nano-composites (Co-pnm) yielded the most promising values of the four nanocomposites tested in terms of X-ray absorption...
May 2015: Journal of Dentistry of Tehran University of Medical Sciences
Chunxia Gao, Ivana Uzelac, Johan Gottfries, Leif A Eriksson
Methicillin resistant Staphylococcus aureus (MRSA) has become a major health concern which has brought about an urgent need for new therapeutic agents. As the S. aureus Sortase A (SrtA) enzyme contributes to the adherence of the bacteria to the host cells, inhibition thereof by small molecules could be employed as potential antivirulence agents, also towards resistant strains. Albeit several virtual docking SrtA campaigns have been reported, no strongly inhibitatory non-covalent binders have as yet emerged therefrom...
2016: Scientific Reports
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