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https://www.readbyqxmd.com/read/29123034/the-virulence-associated-protein-hsva-from-the-fire-blight-pathogen-erwinia-amylovora-is-a-polyamine-amidinotransferase
#1
Sreejesh Shanker, Grace K Schaefer, Benjamin K Barnhart, Vicki L Wallace-Kneale, Dorsin Chang, Thomas J Coyle, David A Metzler, Jeffrey Huang, Jeffrey A Lawton
Studies of virulence determinants in the bacterial phytopathogen Erwinia amylovora, the cause of devastating fire blight disease in apple and pear, have shown that HsvA, a putative amidinotransferase enzyme located in the Hrp pathogenicity island, is required for systemic infection in apple. However, the mechanism by which HsvA contributes to virulence is unclear. To investigate the role of HsvA in virulence, we carried out a series of biochemical and structural studies to characterize the amidinotransferase activity of HsvA...
November 9, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29098883/solid-dispersion-adsorbate-technique-for-improved-dissolution-and-flow-properties-of-lurasidone-hydrochloride-characterization-using-3-2-factorial-design
#2
Ashok Mahajan, Naazneen Surti, Pooja Koladiya
The aim of the present investigation was to improve the dissolution and flow properties of Lurasidone hydrochloride by solid dispersion adsorbate technique. Solid dispersions of Lurasidone hydrochloride were prepared by fusion method using Poloxamer P188. The melt dispersion was adsorbed onto the porous carrier Florite (calcium silicate). A 3(2) factorial design was employed to quantify the effect of two independent variables, namely ratio of carrier (Poloxamer 188) and Lurasidone hydrochloride in solid dispersion and ratio of adsorbent (Florite) to solid dispersion...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28956616/xrays-examining-relevance-of-articles-to-young-survivors-program-survey-of-information-needs-and-media-use-by-young-breast-cancer-survivors-and-young-women-at-high-risk-for-breast-cancer
#3
Robin H Pugh Yi, Lisa F Rezende, Julie Huynh, Karen Kramer, Melissa Cranmer, Lisa Schlager, Craig T Dearfield, Susan J Friedman
Women age 45 years or younger with breast cancer, or who are at high-risk for breast cancer due to previously having the disease or to genetic risk, have distinct health risks and needs from their older counterparts. Young women frequently seek health information through the Internet and mainstream media, but often find it does not address their particular concerns, that it is difficult to evaluate or interpret, or even misleading. To help women better understand media coverage about new research, Facing Our Risk of Cancer Empowered (FORCE) developed the CDC-funded XRAYS (eXamining Relevance of Articles to Young Survivors) program...
September 28, 2017: Health Communication
https://www.readbyqxmd.com/read/28866486/estimation-of-basis-line-integrals-in-a-spectral-distortion-modeled-photon-counting-detector-using-low-rank-approximation-based-x-ray-transmittance-modeling-k-edge-imaging-application
#4
Okkyun Lee, Steffen Kappler, Christoph Polster, Katsuyuki Taguchi
Photon counting detectors (PCD) provide multiple energy-dependent measurements for estimating basis lineintegrals. However, the measured spectrum is distorted from the spectral response effect (SRE) via charge sharing, K-fluorescence emission, etc. Thus, in order to avoid bias and artifacts in images, the SRE needs to be compensated. For this purpose, we recently developed a computationally efficient three-step algorithm for PCD-CT without contrast agents by approximating smooth x-ray transmittance using low-order polynomial bases...
August 29, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28860193/structural-and-functional-insights-into-the-interaction-between-the-cas-family-scaffolding-protein-p130cas-and-the-focal-adhesion-associated-protein-paxillin
#5
Chi Zhang, Darcie J Miller, Cristina D Guibao, Dominique M Donato, Steven K Hanks, Jie J Zheng
The Cas family scaffolding protein p130Cas is a Src substrate localized in focal adhesions (FAs) and functions in integrin signaling to promote cell motility, invasion, proliferation, and survival. p130Cas targeting to FAs is essential for its tyrosine phosphorylation and downstream signaling. Although the N-terminal SH3 domain is important for p130Cas localization, it has also been reported that the C-terminal region is involved in p130Cas FA targeting. The C-terminal region of p130Cas or Cas family homology domain (CCHD) has been reported to adopt a structure similar to that of the focal adhesion kinase C-terminal focal adhesion-targeting domain...
November 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28774434/automatic-measurement-of-the-sinus-of-valsalva-by-image-analysis
#6
Fabrice Mairesse, Cédric Blanchard, Arnaud Boucher, Tadeusz Sliwa, Alain Lalande, Yvon Voisin
BACKGROUND AND OBJECTIVES: Despite the importance of the morphology of the sinus of Valsalva in the behavior of heart valves and the proper irrigation of coronary arteries, the study of these sinuses from medical imaging is still limited to manual radii measurements. This paper aims to present an automatic method to measure the sinuses of Valsalva on medical images, more specifically on cine MRI and Xray CT. METHODS: This paper introduces an enhanced method to automatically localize and extract each sinus of Valsalva edge and its relevant points...
September 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28682254/multiscale-shannon-s-entropy-modelling-of-orientation-and-distance-in-steel-fiber-micro-tomography-data
#7
John P Chiverton, Olubisi Ige, Stephanie J Barnett, Tony Parry
This work is concerned with the modelling and analysis of the orientation and distance between steel fibers in Xray Micro-Tomography (XCT) data. The advantage of combining both orientation and separation in a model is that it helps provide a detailed understanding of how the steel fibers are arranged, which is easy to compare. The developed models are designed to summarise the randomness of the orientation distribution of the steel fibers both locally and across an entire volume based on multiscale entropy...
June 30, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28629466/intra-articular-injection-in-the-knee-of-adipose-derived-stromal-cells-stromal-vascular-fraction-and-platelet-rich-plasma-for-osteoarthritis
#8
Himanshu Bansal, Kristin Comella, Jerry Leon, Poonam Verma, Diwaker Agrawal, Prasad Koka, Thomas Ichim
BACKGROUND: Stromal vascular fraction (SVF) can easily be obtained from a mini-lipoaspirate procedure of fat tissue and platelet rich plasma (PRP) can be obtained from peripheral blood. We evaluated the safety and preliminary efficacy of administering SVF and PRP intra-articularly into patients with osteoarthritis grade 1 and 2. METHODS: A total of ten patients underwent a local tumescent liposuction procedure to remove approximately 100 ml of fat tissue from the abdomen...
June 19, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28435645/angiofibrolipoma-of-posterior-mediastinum-with-transforaminal-extension
#9
Monia Attia, Imen Megdiche, Henda Neji, Ameur Belhadj, Ines Baccouche, Soussen Hantous Zannad, Khaoula Ben Miled M'rad
Angiofibrolipoma is a histological variant of lipoma, which commonly occurs in subcutaneous tissues. In the present report we illustrate the case of an angiofibrolipoma of the posterior upper mediastinum in a 75-year-old man presented with progressive chest pain. Xray chest showed a homogeneous opacity vertically oriented along the right lateral aspect of thoracic vertebrae with an obtuse angle to the mediastinum. The upper extremity of the mass extended above the superior clavicle, suggestive of a posterior mediastinal lesion...
March 24, 2017: Rare Tumors
https://www.readbyqxmd.com/read/28367426/percutaneous-autologous-bone-marrow-derived-mesenchymal-stromal-cell-implantation-is-safe-for-reconstruction-of-human-lower-limb-long-bone-atrophic-nonunion
#10
Mohsen Emadedin, Narges Labibzadeh, Roghayeh Fazeli, Fatemeh Mohseni, Seyedeh Esmat Hosseini, Reza Moghadasali, Soura Mardpour, Vajiheh Azimian, Alireza Goodarzi, Maede Ghorbani Liastani, Ali Mirazimi Bafghi, Mohamadreza Baghaban Eslaminejad, Nasser Aghdami
OBJECTIVE: Nonunion is defined as a minimum of a 9-month period of time since an injury with no visibly progressive signs of healing for 3 months. Recent studies show that application of mesenchymal stromal cells (MSCs) in the laboratory setting is effective for bone regeneration. Animal studies have shown that MSCs can be used to treat nonunions. For the first time in an Iranian population, the present study investigated the safety of MSC implantation to treat human lower limb long bone nonunion...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28306639/defining-the-role-of-the-lower-limbs-in-compensating-for-sagittal-malalignment
#11
Renaud Lafage, Barthelemy Liabaud, Bassel G Diebo, Jonathan H Oren, Shaleen Vira, Sébastien Pesenti, Themistocles S Protopsaltis, Thomas J Errico, Frank J Schwab, Virginie Lafage
MINI: Despite differences in sagittal malalignment, antero-posterior pelvic translation maintained the position of T9 in line with the ankles, independently of sagittal vertical axis. Pelvic tilt was directly predicted by lower limb compensatory mechanisms. Therefore, these adaptation mechanisms being included in pelvic tilt analysis, it does not need additional consideration in the surgical planning. STUDY DESIGN: Retrospective review. OBJECTIVE: To investigate the role of lower limbs compensation with progressive sagittal malalignment...
November 15, 2017: Spine
https://www.readbyqxmd.com/read/28242159/-hydrothorax-as-a-complication-of-a-ventricle-peritoneal-shunt-a-case-report
#12
Raúl M Yéboles, Lorena Vázquez, Marta Seoane, Susana Castro, Beatriz Ruiz
The ventricle peritoneal (VP) shunt is commonly used in the treatment of hydrocephalus. It is a relatively simple and effective technique, but around 70% of the patients with a VP shunt have a complication in their lifetime. Most of these complications are due to infection or mechanical dysfunction. The thoracic complications are rare. The present case is one of the small number of them found in the literature, describing hydrothorax as a complication of a VP shunt without catheter migration and without ascites...
July 2017: Neurocirugía
https://www.readbyqxmd.com/read/28151509/-evaluation-of-tip-location-reliability-of-intraprocedural-ecg-vs-chest-xrays-in-picc-placement
#13
Stefano Elli, Luigi Cannizzo, Alessia Marini, Silvia Porcarelli, Filippo Azzarone, Roberto Fumagalli, Giuseppe Foti, Alberto Lucchini
. Evaluation of tip location reliability of intraprocedural ECG vs. chest Xrays in PICC placement. INTRODUCTION: Among the methods to assess the correct positioning of the tip of central venous catheters, the ECG method is safe and reliable. AIM: To compare the reliability of tip location by intraprocedural ECG and post-procedural radiological examination as implemented in routine care in a tertiary hospital PICC Team. METHODS: 119 PICCs positioned by the Monza hospital PICC Team were examined positioned by either ECG technique or post procedural x-rays technique...
October 2016: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/28150915/multicenter-retrospective-study-on-management-and-outcome-of-newborns-affected-by-surgical-necrotizing-enterocolitis
#14
Silvana Federici, Lorenzo DE Biagi, Simona Straziuso, Ernesto Leva, Giulia Brisighelli, Girolamo Mattioli, Luca Pio, Pietro Bagolan, Giorgia Totonelli, Bruno Noccioli, Elisa Severi, Pierluigi Lelli Chiesa, Gabriele Lisi, Antonino Tramontano, Carolina DE Chiara, Carmine Del Rossi, Giovanni Casadio, Mario Messina, Rossella Angotti, Antonino Appignani, Mirko Bertozzi, Fabio Rossi, Valeria Gabriele, Andrea Franchella, Veronica Zocca
BACKGROUND: Necrotizing enterocolitis (NEC) is the most common surgical emergency in newborns and it is still a leading cause of death despite the improvements reached in the management of the critically ill neonate. The purpose of this study was to evaluate risk factors, surgical treatments and outcome of surgical NEC. METHODS: We retrospectively evaluated a multicentric group of 184 patients with surgical NEC over a period of 5 years (2008-2012). Indications to operation were modified NEC Bell stages IIIA or IIIB...
June 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/28068107/effect-of-pressure-on-dielectric-and-frank-elastic-constants-of-a-material-exhibiting-the-twist-bend-nematic-phase
#15
Srividhya Parthasarathi, D S Shankar Rao, Nani Babu Palakurthy, C V Yelamaggad, S Krishna Prasad
We report the first investigation on the effect of applied pressure on the now well-known dimer α,ω bis(4,4'-cyanobiphenyl)heptane (CB7CB) that exhibits two types of nematic: the regular uniaxial nematic (N) and the recently discovered twist-bend nematic (NTB) phase. At atmospheric pressure, the thermal behavior of ε⊥, the permittivity normal to the director in the N phase decreases on entering the NTB wherein the value represents permittivity orthogonal to the helical axis. Application of pressure initially decreases the magnitude of the change in ε⊥ and with further increase in pressure exhibits an increase in the value...
January 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28058100/non-mucinous-lepidic-predominant-adenocarcinoma-presenting-with-extensive-aerogenous-spread
#16
Yusuke Takanashi, Shogo Tajima, Masaru Tsukui, Kazuya Shinmura, Takamitsu Hayakawa, Tsuyoshi Takahashi, Hiroshi Neyatani, Kazuhito Funai
An extremely rare case of non-mucinous lepidic-predominant invasive adenocarcinoma (LPA) showing extensive aerogenous spread with a pneumonic presentation is reported. A 73-year-old woman was referred to our hospital because of an infiltrative shadow on chest xray. Chest computed tomography revealed extensive ground glass opacities in the right lower lobe, which was accompanied by infiltrative shadow with a pneumonic presentation. Invasive mucinous adenocarcinoma was presumed, and a partial resection of the right lower lobe was done...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28046487/th-a-204-00-key-dosimetry-data-impact-of-new-icru-recommendations
#17
Ronald Tosh
The ICRU is currently finalizing a report on key data for radiation dosimetry. This multi-year review has resulted in a number of recommendations regarding "fundamental" data that are used in dosimetry related to radiation therapy. This educational session will explain the background for the ICRU committee's work, the content and conclusions of the report and the impact on outputs, including NIST primary standards, ADCL calibration coefficients and clinical reference dosimetry. Parameters and beam modalities potentially affected by this report include: The mean excitation energy, I, for graphite, air, and water, The average energy required to create an ion pair in dry air (commonly referred to as W/e), The uncertainty in the determination of air kerma in kV xrays The absolute value of Co-60 and Cs-137 primary standards and the dissemination of calibration coefficients, The determination of air kerma strength for Ir-192 HDR brachytherapy sources Ion chamber kQ factors for linac MV beams Ion chamber kQ factors for proton beams...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27977416/novel-fluorescent-cdte-quantum-dot-thymine-conjugate-synthesis-properties-and-possible-application
#18
Łucja Rodzik, Joanna Lewandowska-Łańcucka, Michał Szuwarzyński, Krzysztof Szczubiałka, Maria Nowakowska
Novel, highly fluorescent cadmium telluride quantum dots conjugated with thymine and stabilized with thioglycolic acid were obtained and characterized. Successful formation of the conjugate was confirmed by elemental analysis, and UV-vis, fluorescence and Fourier transform infrared spectroscopies. Crystal structure and composition of the conjugates were characterized with xray diffraction and x-ray photoelectron spectroscopy. The size of the conjugates was 4-6 nm as demonstrated using atomic force microscopy and high resolution transmission electron microscopy imaging...
January 27, 2017: Nanotechnology
https://www.readbyqxmd.com/read/27922577/is-it-in-or-out-the-optimal-fluoroscopic-views-for-intraoperative-determination-of-proper-lateral-mass-screw-placement
#19
Sang Bum Kim, John M Rhee, Byung Hak Oh, You Gun Won, Yousun Jung, Kun Young Park, William C Hutton, Chulmin Kim
STUDY DESIGN: Cadaveric. OBJECTIVE: Determine optimal fluoroscopic views for detecting cervical lateral mass screw (LMS) violations. SUMMARY OF BACKGROUND DATA: Single plane intraoperative x-rays are commonly used but frequently inadequate due to its complex trajectory. Fluoroscopy can be taken in multiple planes, but the ideal fluoroscopic view to assess malposition is not known: depending on the view, any given screw may look "in" or "out...
July 15, 2017: Spine
https://www.readbyqxmd.com/read/27860342/compliance-with-a-copd-bundle-of-care-in-an-australian-emergency-department-a-cohort-study
#20
Alexis Gerber, Catriona Moynihan, Sharon Klim, Peter Ritchie, Anne-Maree Kelly
INTRODUCTION: Bundles of care are gaining popularity for treating acute severe illness. OBJECTIVE: To describe compliance with bundle of care elements (individually and as a "bundle") for patients treated for chronic obstructive pulmonary disease (COPD) exacerbations in the emergency department (ED). METHODS: Retrospective observational study of patients presenting in the 2014 calendar year with an ED diagnosis of COPD. The primary outcomes of interest were compliance with key bundle of care elements (individually and as a "bundle")...
November 18, 2016: Clinical Respiratory Journal
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