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cervical priming

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https://www.readbyqxmd.com/read/28255768/different-routes-of-misoprostol-for-cervical-priming-in-first-trimester-surgical-abortions-a-randomized-blind-trial
#1
Hadas Ganer Herman, Ram Kerner, Ohad Gluck, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
PURPOSE: To compare effectiveness and patient satisfaction of different routes of misoprostol for short-term (same day) cervical priming in first trimester surgical abortions. METHODS: In a blind randomized trial, patients undergoing surgical abortion at a gestational age of 6 + 0-14 + 6 were administered oral, vaginal, or sub-lingual 400 mcg misoprostol, 1.5 to 4 h prior to procedure. Surgeons blinded to patient allocation evaluated cervical priming. The primary outcome was initial cervical dilatation...
March 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28216674/ccr7-deficient-inflammatory-dendritic-cells-are-retained-in-the-central-nervous-system
#2
Benjamin D Clarkson, Alec Walker, Melissa G Harris, Aditya Rayasam, Martin Hsu, Matyas Sandor, Zsuzsanna Fabry
Dendritic cells (DC) accumulate in the CNS during neuroinflammation, yet, how these cells contribute to CNS antigen drainage is still unknown. We have previously shown that after intracerebral injection, antigen-loaded bone marrow DC migrate to deep cervical lymph nodes where they prime antigen-specific T cells and exacerbate experimental autoimmune encephalomyelitis (EAE) in mice. Here, we report that DC migration from brain parenchyma is dependent upon the chemokine receptor CCR7. During EAE, both wild type and CCR7-/- CD11c-eYFP cells infiltrated into the CNS but cells that lacked CCR7 were retained in brain and spinal cord while wild type DC migrated to cervical lymph nodes...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28166180/therapeutic-vaccine-against-primate-papillomavirus-infections-of-the-cervix
#3
Emeline Ragonnaud, Anne-Marie C Andersson, Silmi Mariya, Anders G Pedersen, Robert D Burk, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Joko Pamungkas, Diah Iskandriati, Peter J Holst
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillomavirus (HPVs) infections, do not target all oncogenic HPVs and are insufficient to eliminate the burden of HPV induced cancer. We aim to develop an alternative HPV vaccine which is broadly effective and capable of clearing preexisting infection. In an initial attempt to develop a broadly reactive therapeutic vaccine, we designed a putative papillomavirus (PV) ancestor antigen (circulating sequence derived antigenic sequences E1E2-CDSE1E2) based on the conserved E1 and E2 protein sequences from existing oncogenic HPV strains...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#4
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28069480/different-routes-of-misoprostol-for-same-day-cervical-priming-prior-to-operative-hysteroscopy-a-randomized-blind-trial
#5
Hadas Ganer Herman, Ram Kerner, Ohad Gluk, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
STUDY OBJECTIVE: To compare the effectiveness and patient satisfaction of different routes of misoprostol for short term cervical priming prior to operative hysteroscopy. DESIGN: randomized blind trial DESIGN: classification: Canadian Task Force classification I SETTING: University hospital PATIENTS: 120 patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomly assigned to receive 400 μg misoprostol administered orally (n=40), vaginally (n=40) and sub-lingual (n=40) for cervical priming 1...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28056123/the-interface-of-mechanics-and-nociception-in-joint-pathophysiology-insights-from-the-facet-and-temporomandibular-joints
#6
Megan M Sperry, Meagan E Ita, Sonia Kartha, Sijia Zhang, Ya-Hsin Yu, Beth Winkelstein
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma. Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and molecular mechanisms contributing to synovial joint pain are reviewed using two examples, the cervical spinal facet joints and the temporomandibular joint (TMJ). Although much work has focused on the macroscale mechanics of joints in health and disease, the combined influence of tissue mechanics, molecular processes, and nociception in joint pain has only recently become a focus...
February 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27981257/assessing-the-efficacy-of-vaginal-hyoscine-butyl-bromide-on-cervical-ripening-prior-to-intrauterine-procedures-a-double-blinded-clinical-trial
#7
Shiva Hadadian, Masoumeh Fallahian
BACKGROUND: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications. OBJECTIVE: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients. MATERIALS AND METHODS: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27796368/targeting-non-classical-myelin-epitopes-to-treat-experimental-autoimmune-encephalomyelitis
#8
Xiaohua Wang, Jintao Zhang, David J Baylink, Chih-Huang Li, Douglas M Watts, Yi Xu, Xuezhong Qin, Michael H Walter, Xiaolei Tang
Qa-1 epitopes, the peptides that bind to non-classical major histocompatibility complex Ib Qa-1 molecules and are recognized by Qa-1-restricted CD8(+) regulatory T (Treg) cells, have been identified in pathogenic autoimmune cells that attack myelin sheath in experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis [MS]). Additionally, immunization with such epitopes ameliorates the EAE. However, identification of such epitopes requires knowledge of the pathogenic autoimmune cells which are largely unknown in MS patients...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27697286/the-effect-of-transplanted-human-wharton-s-jelly-mesenchymal-stem-cells-treated-with-ifn-%C3%AE-on-experimental-autoimmune-encephalomyelitis-mice
#9
Mohammad Torkaman, Marzieh Ghollasi, Mousa Mohammadnia-Afrouzi, Ali Salimi, Afshin Amari
Interferon gamma (IFN-γ) increases the immunosuppressive property of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs). In this study, we evaluated the therapeutic effects of IFN-γ primed WJ-MSCs in EAE mice. IFN-γ primed WJ-MSCs were injected on days 3 and 11 after EAE induction. 21 days after EAE induction, splenocytes and cervical lymph node cells were isolated and cell proliferation, secretion of inflammatory cytokines and frequency of regulatory T-cells was measured. On day 50 of the study, cell infiltration and gene expression of inflammatory cytokines in brain of mice were studied...
January 2017: Cellular Immunology
https://www.readbyqxmd.com/read/27679244/cervical-priming-prior-to-operative-hysteroscopy-a-randomized-controlled-study-comparing-the-efficacy-of-laminaria-versus-evening-primrose-oil-epo
#10
Mlc Tanchoco, A S Aguilar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27676456/induction-of-mucosal-immune-responses-against-helicobacter-pylori-infection-after-sublingual-and-intragastric-route-of-immunization
#11
Louise Sjökvist Ottsjö, Frida Jeverstam, Linda Yrlid, Alexander U Wenzel, Anna K Walduck, Sukanya Raghavan
There is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against Helicobacter pylori, which causes a chronic infection that can lead to peptic ulcers and gastric cancer in a subpopulation of infected individuals. Mucosal CD4(+) T-cell responses have been shown to be essential for vaccine-induced protection against H. pylori infection. The current study addresses the influence of the adjuvant and site of mucosal immunization on early CD4(+) T-cell priming to H...
February 2017: Immunology
https://www.readbyqxmd.com/read/27660411/the-use-of-misoprostol-for-cervical-priming-prior-to-hysteroscopy-a-systematic-review-and-analysis
#12
Ying Hua, Wenwen Zhang, Xiaoli Hu, Ansu Yang, Xueqiong Zhu
The effects of misoprostol use on cervical priming prior to hysteroscopy have been controversial. Therefore, a systematic literature review and meta-analysis of studies were conducted to assess the effect of misoprostol on cervical priming prior to hysteroscopy. All studies published before July 2014 with data related to the use of misoprostol for cervical priming compared with placebo or no medication prior to hysteroscopy, were identified. Twenty-five randomized controlled trials involving 2,203 females were systematically analyzed...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27621024/industry-academic-partnerships-an-approach-to-accelerate-innovation
#13
Jennwood Chen, Timothy Pickett, Ashley Langell, Ashley Trane, Brian Charlesworth, Kris Loken, Sarah Lombardo, John T Langell
BACKGROUND: Biotechnology companies are process-driven organizations and often struggle with their ability to innovate. Universities, on the other hand, thrive on discovery and variation as a source of innovation. As such, properly structured academic-industry partnerships in medical technology development may enhance and accelerate innovation. Through joint industry-academic efforts, our objective was to develop a technology aimed at global cervical cancer prevention. METHODS: Our Center for Medical Innovation assembled a multidisciplinary team of students, surgical residents, and clinical faculty to enter in the University of Utah's annual Bench-to-Bedside competition...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27566696/randomized-double-blind-placebo-controlled-study-of-preinduction-cervical-priming-with-25%C3%A2-%C3%A2%C2%B5g-of-misoprostol-in-the-outpatient-setting-to-prevent-formal-induction-of-labour
#14
Jameela PonMalar, Santosh Joseph Benjamin, Anuja Abraham, Swati Rathore, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 38(1/2) and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD: Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3...
August 26, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27523921/cervical-priming-by-vaginal-or-oral-misoprostol-before-operative-hysteroscopy-a-double-blind-randomized-controlled-trial
#15
Adel M Nada, Ahmed R Elzayat, Mohamed H Awad, Ahmed A Metwally, Ayman M Taher, Asmaa I Ogila, Ahmed N Askalany, Reham A Mohsen, Mona Mostafa, Hoda Abdelaal
STUDY OBJECTIVE: To evaluate whether misoprostol oral is as effective as vaginal tablets for cervical ripening. DESIGN: Randomized controlled trial involving a parallel, double-blinded study (Canadian Task Force Classification IB). SETTING: Department of Obstetrics and Gynecology, Cairo University Hospital, between January 2014 and January 2016. PATIENTS: Patients undergoing operative hysteroscopy for various indications...
August 11, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27523740/immunogenicity-of-next-generation-hpv-vaccines-in-non-human-primates-measles-vectored-hpv-vaccine-versus-pichia-pastoris-recombinant-protein-vaccine
#16
Gaurav Gupta, Viviana Giannino, Narayan Rishi, Reinhard Glueck
Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. HPVs are oncogenic small double-stranded DNA viruses that are the primary causal agent of cervical cancer and other types of cancers, including in the anus, oropharynx, vagina, vulva, and penis. Prophylactic vaccination against HPV is an attractive strategy for preventing cervical cancer and some other types of cancers. However, there are few safe and effective vaccines against HPV infections. Current first-generation commercial HPV vaccines are expensive to produce and deliver...
September 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27485480/seminal-fluid-and-fertility-in-women
#17
REVIEW
Sarah A Robertson, David J Sharkey
Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive physiology is now evident. Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact with the female reproductive tract to prime the immune response, with consequences for fertility and pregnancy outcome. Experiments in rodent models demonstrate a key role for seminal fluid in enabling robust embryo implantation and optimal placental development...
September 1, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27468274/state-anxiety-subjective-imbalance-and-handicap-in-vestibular-schwannoma
#18
Yougan Saman, Lucie Mclellan, Laurence Mckenna, Mayank B Dutia, Rupert Obholzer, Gerald Libby, Michael Gleeson, Doris-Eva Bamiou
INTRODUCTION: Evidence is emerging for a significant clinical and neuroanatomical relationship between balance and anxiety. Research has suggested a potentially priming effect with anxiety symptoms predicting a worsening of balance function in patients with underlying balance dysfunction. We propose to show that a vestibular stimulus is responsible for an increase in state anxiety, and there is a relationship between increased state anxiety and worsening balance function. AIMS: (1) To quantify state anxiety following a vestibular stimulus in patients with a chronic vestibular deficit...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27407834/misoprostol-as-aid-in-first-trimester-mtp
#19
Shakti Vardhan, R C Behera, G S Sandhu, B K Goyal
BACKGROUND: Medical Termination of Pregnancy (MTP) is a commonly performed during the first trimester. Dilatation and Evacuation (D & E) mandates rapid dilatation of cervix with metal dilators, which requires anaesthesia and may be associated with trauma to the uterus, cervix and later cervical incompetence. The problem of rapid cervical dilatation is obviated with intravaginal misoprostol. METHODS: Intravaginal misoprostol tablet 200 microgram was inserted, a night prior to MTP to ripen the cervix...
January 2006: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/27167552/cardiovascular-effects-of-radiotherapy-on-the-patient-with-cancer
#20
Leonardo Augusto Robert Moreira, Eduardo Nani Silva, Mario Luiz Ribeiro, Wolney de Andrade Martins
The incidence of cancer (CA) has increased globally and radiotherapy (RT) is a vital component in its treatment. Cardiovascular injuries induced by RT in the treatment of thoracic and cervical CA have been causing problems in clinical practice for decades, and are among the most serious adverse effects of radiation experienced by the growing number of cancer survivors. This article presentes a review on the Lilacs, Scielo and Pubmed databases of the main cardiovascular injuries, their mechanisms, clinical presentations, treatments and prevention proposals...
April 2016: Revista da Associação Médica Brasileira
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