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cervical priming

Xiaohua Wang, Jintao Zhang, David J Baylink, Chih-Huang Li, Douglas M Watts, Yi Xu, Xuezhong Qin, Michael H Walter, Xiaolei Tang
Qa-1 epitopes, the peptides that bind to non-classical major histocompatibility complex Ib Qa-1 molecules and are recognized by Qa-1-restricted CD8(+) regulatory T (Treg) cells, have been identified in pathogenic autoimmune cells that attack myelin sheath in experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis [MS]). Additionally, immunization with such epitopes ameliorates the EAE. However, identification of such epitopes requires knowledge of the pathogenic autoimmune cells which are largely unknown in MS patients...
October 31, 2016: Scientific Reports
Mohammad Torkaman, Marzieh Ghollasi, Mousa Mohammadnia-Afrouzi, Ali Salimi, Afshin Amari
Interferon gamma (IFN-γ) increases the immunosuppressive property of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs). In this study, we evaluated the therapeutic effects of IFN-γ primed WJ-MSCs in EAE mice. IFN-γ primed WJ-MSCs were injected on days 3 and 11 after EAE induction. 21 days after EAE induction, splenocytes and cervical lymph node cells were isolated and cell proliferation, secretion of inflammatory cytokines and frequency of regulatory T-cells was measured. On day 50 of the study, cell infiltration and gene expression of inflammatory cytokines in brain of mice were studied...
September 28, 2016: Cellular Immunology
Mlc Tanchoco, A S Aguilar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Louise Sjökvist Ottsjö, Frida Jeverstam, Linda Yrlid, Alexander U Wenzel, Anna K Walduck, Sukanya Raghavan
There is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against Helicobacter pylori, a chronic infection that can lead to peptic ulcers and gastric cancer in a sub-population of infected individuals. Mucosal CD4(+) T cell responses have been shown to be essential for vaccine-induced protection against H. pylori infection. The current study addresses the influence of the adjuvant and site of mucosal immunization on early CD4(+) T cell priming to H. pylori antigens...
September 27, 2016: Immunology
Ying Hua, Wenwen Zhang, Xiaoli Hu, Ansu Yang, Xueqiong Zhu
The effects of misoprostol use on cervical priming prior to hysteroscopy have been controversial. Therefore, a systematic literature review and meta-analysis of studies were conducted to assess the effect of misoprostol on cervical priming prior to hysteroscopy. All studies published before July 2014 with data related to the use of misoprostol for cervical priming compared with placebo or no medication prior to hysteroscopy, were identified. Twenty-five randomized controlled trials involving 2,203 females were systematically analyzed...
2016: Drug Design, Development and Therapy
Jennwood Chen, Timothy Pickett, Ashley Langell, Ashley Trane, Brian Charlesworth, Kris Loken, Sarah Lombardo, John T Langell
BACKGROUND: Biotechnology companies are process-driven organizations and often struggle with their ability to innovate. Universities, on the other hand, thrive on discovery and variation as a source of innovation. As such, properly structured academic-industry partnerships in medical technology development may enhance and accelerate innovation. Through joint industry-academic efforts, our objective was to develop a technology aimed at global cervical cancer prevention. METHODS: Our Center for Medical Innovation assembled a multidisciplinary team of students, surgical residents, and clinical faculty to enter in the University of Utah's annual Bench-to-Bedside competition...
September 2016: Journal of Surgical Research
Jameela PonMalar, Santosh Joseph Benjamin, Anuja Abraham, Swati Rathore, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 38(1/2) and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD: Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3...
August 26, 2016: Archives of Gynecology and Obstetrics
Adel M Nada, Ahmed R Elzayat, Mohamed H Awad, Ahmed A Metwally, Ayman M Taher, Asmaa I Ogila, Ahmed N Askalany, Reham A Mohsen, Mona Mostafa, Hoda Abdelaal
STUDY OBJECTIVE: To evaluate whether misoprostol oral is as effective as vaginal tablets for cervical ripening. DESIGN: Randomized controlled trial involving a parallel, double-blinded study (Canadian Task Force Classification IB). SETTING: Department of Obstetrics and Gynecology, Cairo University Hospital, between January 2014 and January 2016. PATIENTS: Patients undergoing operative hysteroscopy for various indications...
August 11, 2016: Journal of Minimally Invasive Gynecology
Gaurav Gupta, Viviana Giannino, Narayan Rishi, Reinhard Glueck
Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide. HPVs are oncogenic small double-stranded DNA viruses that are the primary causal agent of cervical cancer and other types of cancers, including in the anus, oropharynx, vagina, vulva, and penis. Prophylactic vaccination against HPV is an attractive strategy for preventing cervical cancer and some other types of cancers. However, there are few safe and effective vaccines against HPV infections. Current first-generation commercial HPV vaccines are expensive to produce and deliver...
September 7, 2016: Vaccine
Sarah A Robertson, David J Sharkey
Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive physiology is now evident. Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact with the female reproductive tract to prime the immune response, with consequences for fertility and pregnancy outcome. Experiments in rodent models demonstrate a key role for seminal fluid in enabling robust embryo implantation and optimal placental development...
September 1, 2016: Fertility and Sterility
Yougan Saman, Lucie Mclellan, Laurence Mckenna, Mayank B Dutia, Rupert Obholzer, Gerald Libby, Michael Gleeson, Doris-Eva Bamiou
INTRODUCTION: Evidence is emerging for a significant clinical and neuroanatomical relationship between balance and anxiety. Research has suggested a potentially priming effect with anxiety symptoms predicting a worsening of balance function in patients with underlying balance dysfunction. We propose to show that a vestibular stimulus is responsible for an increase in state anxiety, and there is a relationship between increased state anxiety and worsening balance function. AIMS: (1) To quantify state anxiety following a vestibular stimulus in patients with a chronic vestibular deficit...
2016: Frontiers in Neurology
Shakti Vardhan, R C Behera, G S Sandhu, B K Goyal
BACKGROUND: Medical Termination of Pregnancy (MTP) is a commonly performed during the first trimester. Dilatation and Evacuation (D & E) mandates rapid dilatation of cervix with metal dilators, which requires anaesthesia and may be associated with trauma to the uterus, cervix and later cervical incompetence. The problem of rapid cervical dilatation is obviated with intravaginal misoprostol. METHODS: Intravaginal misoprostol tablet 200 microgram was inserted, a night prior to MTP to ripen the cervix...
January 2006: Medical Journal, Armed Forces India
Leonardo Augusto Robert Moreira, Eduardo Nani Silva, Mario Luiz Ribeiro, Wolney de Andrade Martins
The incidence of cancer (CA) has increased globally and radiotherapy (RT) is a vital component in its treatment. Cardiovascular injuries induced by RT in the treatment of thoracic and cervical CA have been causing problems in clinical practice for decades, and are among the most serious adverse effects of radiation experienced by the growing number of cancer survivors. This article presentes a review on the Lilacs, Scielo and Pubmed databases of the main cardiovascular injuries, their mechanisms, clinical presentations, treatments and prevention proposals...
April 2016: Revista da Associação Médica Brasileira
Miguel Bardon, Noel Young, Poppy Sindhusake, Theresa Lee, Ken Le
BACKGROUND: Multitrauma patients represent a difficult cohort of patients from a diagnostic standpoint. Current trauma recommendations do not advise whole-body computed tomography (CT) in hemodynamically stable patients. OBJECTIVE: To measure the prevalence of abnormal CT findings in areas other than the prime area of clinical interest in multitrauma patients. METHOD: The records of 462 consecutive adult patients who underwent whole-body CT scans between 2004 and 2005 at Westmead Hospital, a Level 1 trauma center, were assessed...
2012: Open Access Emergency Medicine: OAEM
Marisa Jackson, Warren Tourtellotte
The rodent superior cervical ganglion (SCG) is a useful and readily accessible source of neurons for studying the mechanisms of sympathetic nervous system (SNS) development and growth in vitro. The sympathetic nervous system (SNS) of early postnatal animals undergoes a great deal of remodeling and development; thus, neurons taken from mice at this age are primed to re-grow and establish synaptic connections after in situ removal. The stereotypic location and size of the SCG make it ideal for rapid isolation and dissociation...
January 20, 2014: Bio-protocol
Atul Goel
BACKGROUND: Multilevel ossified posterior longitudinal ligaments (OPLLs), particularly those that extend into the high cervical region, are formidable and challenging surgical problems. The aim of the presentation is to analyze the results of surgical treatment of seven consecutive patients having high cervical OPLL with atlantoaxial and subaxial facetal fixations. OBJECTIVES: We analyze the role of atlantoaxial instability in the management of OPLL that extended into the high cervical region, above the lower border of C3 vertebra...
January 2016: Journal of Craniovertebral Junction and Spine
Seok Voon White, Chris E Czisch, May H Han, Christine D Plant, Alan R Harvey, Giles W Plant
Cellular transplantation strategies utilizing intraspinal injection of mesenchymal progenitor cells (MPCs) have been reported as beneficial for spinal cord injuries. However, intraspinal injection is not only technically challenging, but requires invasive surgical procedures for patients. Therefore, we investigated the feasibility and potential benefits of noninvasive intravenous injection of MPCs in two models of cervical spinal cord injury, unilateral C5 contusion and complete unilateral C5 hemisection. MPCs isolated from green fluorescence protein (GFP)-luciferase transgenic mice compact bone (1 × 10(6) cells), or vehicle Hank's Buffered Saline Solution (HBSS), were intravenously injected via the tail vein at D1, D3, D7, D10, or D14...
July 2016: Stem Cells
B Yu, Y An, G Xu, H Shan
UNLABELLED: Rapid, sensitive and specific isothermal nucleic acid amplification methods of Chlamydia trachomatis (C. trachomatis) and Neisseria gonorrhoeae (N. gonorrhoeae) have been developed based on cross-priming amplification (CPA). The amplicon of CPA can be detected by a disposable amplicon cross-contamination proof device. The whole assay takes 1-1·5 h from amplification to read out. Ten fold serial dilutions of quantified plasmids were used to test the CPA assay sensitivities, with the detection limits of 45 copies per reaction and 65 copies per reaction for C...
May 2016: Letters in Applied Microbiology
Shiwen Peng, Jin Qiu, Andrew Yang, Benjamin Yang, Jessica Jeang, Joshua W Wang, Yung-Nien Chang, Cory Brayton, Richard B S Roden, Chien-Fu Hung, T-C Wu
BACKGROUND: Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer as well as subsets of anogenital and oropharyngeal cancers. The two HPV viral oncoproteins, E6 and E7, are uniquely and consistently expressed in all HPV infected cells and are therefore promising targets for therapeutic vaccination. Both recombinant naked DNA and protein-based HPV vaccines have been demonstrated to elicit HPV-specific CD8+ T cell responses that provide therapeutic effects against HPV-associated tumor models...
2016: Cell & Bioscience
Shima Mohammadian, Anahita Tavana, Shahrzad Tavana, Aida Mohammadian, Masoumeh Fallahian
BACKGROUND: Difficulty in cervical dilatation is a hard situation during the procedure of diagnostic dilatation and curettage in some cases. This study was performed to evaluate the effect of vaginal misoprostol for cervical priming before diagnostic dilatation and curettage. METHODS: In this study 56 women were selected as the candidates for dilatation and curettage. The study was double blind and was performed for two parallel groups. One misoprostol tablet (200 μg) was administered in posterior fornix of vagina 2-4 hr before operation in 28 patients whereas in other 28 patients, placebo (VitB6) was used...
July 2015: Journal of Reproduction & Infertility
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