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cervical priming

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https://www.readbyqxmd.com/read/28506297/cervical-cancer-treatment-costs-and-cost-effectiveness-analysis-of-human-papillomavirus-vaccination-in-vietnam-a-prime-modeling-study
#1
Hoang Van Minh, Nguyen Thi Tuyet My, Mark Jit
BACKGROUND: Cervical cancer is currently the leading cause of cancer mortality among women in South Vietnam and the second leading cause of cancer mortality in North Vietnam. Human papillomavirus (HPV) vaccination has the potential to substantially decrease this burden. The World Health Organization (WHO) recommends that a cost-effectiveness analysis of HPV vaccination is conducted before nationwide introduction. METHODS: The Papillomavirus Rapid Interface for Modeling and Economics (PRIME) model was used to evaluate the cost-effectiveness of HPV vaccine introduction...
May 15, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28502106/misoprostol-for-cervical-priming-prior-to-office-hysteroscopy-works-in-premenopausal-nulliparous-but-not-in-postmenopausal-women
#2
Shagaf Bakour
This randomized controlled trial (RCT) by Tasma et al. reports on pain at hysteroscopy. This is an important subject since hysteroscopy is the single most common procedure in gynaecology. There has been limited or conflicting evidence regarding misoprostol for cervical priming prior to hysteroscopy. Although there have been three meta-analyses and 25 RCTs published to date, the heterogeneity among regimens, doses, and route of administration plus clinical diversity, make analysis of the data difficult. This article is protected by copyright...
May 14, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28403891/foley-catheter-for-cervical-priming-in-induction-of-labour-at-university-obstetrics-unit-colombo-sri-lanka-a-clinical-audit-with-a-patient-satisfaction-survey
#3
M Patabendige, A Jayawardane
BACKGROUND: Intracervical insertion of a Foley catheter (FC) has shown to be a safe, effective and relatively feasible mechanical method of cervical priming in induction of labour (IOL). We evaluated indications, effectiveness, patient acceptability and outcomes of FC use in IOL adhering to the ward protocol in our unit. METHODS: A clinical audit with a patient satisfaction survey conducted between July and September 2013 in University Obstetric Unit, Colombo, Sri Lanka...
April 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28402552/induced-abortion
#4
(no author information available yet)
Abortion is common. Data on abortion rates are inexact but can be used to explore trends. Globally, the estimated rate in the period 2010-2014 was 35 abortions per 1000 women (aged 15-44 years), five points less than the rate of 40 for the period 1990-1994. Abortion laws vary around the world but are generally more restrictive in developing countries. Restrictive laws do not necessarily deter women from seeking abortion but often lead to unsafe practice with significant mortality and morbidity. While a legal framework for abortion is a prerequisite for availability, many laws, which are not evidence based, restrict availability and delay access...
June 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28376961/abrasion-a-common-dental-problem-revisited
#5
Alex Milosevic
Dental abrasion is most commonly seen at the cervical necks of teeth, but can occur in any area, even inter-dentally from vigorous and incorrect use of dental floss. Acid erosion has been implicated in the initiation and progress of the cervical lesion, while tooth-brush abrasion has long been held as the prime cause of cervical abrasion. Identification of the risk factors is clearly important in order to modify any habits and provide appropriate advice.
February 28, 2017: Primary Dental Journal
https://www.readbyqxmd.com/read/28363606/observational-study-of-neonatal-safety-for-outpatient-labour-induction-priming-with-dinoprostone-vaginal-insert
#6
Geoffrey W Cundiff, Mary Lynn Simpson, Nicole Koenig, Terry Lee
OBJECTIVES: To evaluate the safety of outpatient induction with dinoprostone insert in low-risk labour inductions for premature rupture of membranes or postdates gestation. METHODS: This retrospective cohort study compared outpatient labour induction priming with inpatient induction in terms of neonatal safety, mode of delivery, and obstetrical parameters. The sample included all inductions for premature rupture of membranes or postdate gestation. The analysis used logistic regression...
March 28, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28255768/different-routes-of-misoprostol-for-cervical-priming-in-first-trimester-surgical-abortions-a-randomized-blind-trial
#7
Hadas Ganer Herman, Ram Kerner, Ohad Gluck, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
PURPOSE: To compare effectiveness and patient satisfaction of different routes of misoprostol for short-term (same day) cervical priming in first trimester surgical abortions. METHODS: In a blind randomized trial, patients undergoing surgical abortion at a gestational age of 6 + 0-14 + 6 were administered oral, vaginal, or sub-lingual 400 mcg misoprostol, 1.5 to 4 h prior to procedure. Surgeons blinded to patient allocation evaluated cervical priming. The primary outcome was initial cervical dilatation...
April 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28216674/ccr7-deficient-inflammatory-dendritic-cells-are-retained-in-the-central-nervous-system
#8
Benjamin D Clarkson, Alec Walker, Melissa G Harris, Aditya Rayasam, Martin Hsu, Matyas Sandor, Zsuzsanna Fabry
Dendritic cells (DC) accumulate in the CNS during neuroinflammation, yet, how these cells contribute to CNS antigen drainage is still unknown. We have previously shown that after intracerebral injection, antigen-loaded bone marrow DC migrate to deep cervical lymph nodes where they prime antigen-specific T cells and exacerbate experimental autoimmune encephalomyelitis (EAE) in mice. Here, we report that DC migration from brain parenchyma is dependent upon the chemokine receptor CCR7. During EAE, both wild type and CCR7-/- CD11c-eYFP cells infiltrated into the CNS but cells that lacked CCR7 were retained in brain and spinal cord while wild type DC migrated to cervical lymph nodes...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28166180/therapeutic-vaccine-against-primate-papillomavirus-infections-of-the-cervix
#9
Emeline Ragonnaud, Anne-Marie C Andersson, Silmi Mariya, Anders G Pedersen, Robert D Burk, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Joko Pamungkas, Diah Iskandriati, Peter J Holst
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillomavirus (HPVs) infections, do not target all oncogenic HPVs and are insufficient to eliminate the burden of HPV induced cancer. We aim to develop an alternative HPV vaccine which is broadly effective and capable of clearing preexisting infection. In an initial attempt to develop a broadly reactive therapeutic vaccine, we designed a putative papillomavirus (PV) ancestor antigen (circulating sequence derived antigenic sequences E1E2-CDSE1E2) based on the conserved E1 and E2 protein sequences from existing oncogenic HPV strains...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28109045/misoprostol-for-cervical-priming-prior-to-hysteroscopy-in-postmenopausal-and-premenopausal-nulliparous-women-a-multicentre-randomised-placebo-controlled-trial
#10
M L Tasma, M Louwerse, W J Hehenkamp, P M Geomini, M Y Bongers, S Veersema, P J van Kesteren, E Tromp, J A Huirne, G C Graziosi
OBJECTIVE: To evaluate the reduction of pain by Misoprostol compared to placebo prior to hysteroscopy in postmenopausal and premenopausal nulliparous women. DESIGN: Randomised multicentre double-blind placebo controlled trial. SETTING: Two Dutch teaching hospitals and one Dutch university medical centre. POPULATION: Postmenopausal and premenopausal nulliparous women undergoing office hysteroscopy. METHODS: Patients were randomised to receive either 400 mcg Misoprostol or placebo 12 and 24 hours before hysteroscopy...
January 21, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28069480/different-routes-of-misoprostol-for-same-day-cervical-priming-prior-to-operative-hysteroscopy-a-randomized-blind-trial
#11
Hadas Ganer Herman, Ram Kerner, Ohad Gluk, Hagit Feit, Ran Keidar, Jacob Bar, Ron Sagiv
STUDY OBJECTIVE: To compare the effectiveness and patient satisfaction of different routes of misoprostol for short term cervical priming prior to operative hysteroscopy. DESIGN: randomized blind trial DESIGN: classification: Canadian Task Force classification I SETTING: University hospital PATIENTS: 120 patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomly assigned to receive 400 μg misoprostol administered orally (n=40), vaginally (n=40) and sub-lingual (n=40) for cervical priming 1...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28056123/the-interface-of-mechanics-and-nociception-in-joint-pathophysiology-insights-from-the-facet-and-temporomandibular-joints
#12
Megan M Sperry, Meagan E Ita, Sonia Kartha, Sijia Zhang, Ya-Hsin Yu, Beth Winkelstein
Chronic joint pain is a widespread problem that frequently occurs with aging and trauma. Pain occurs most often in synovial joints, the body's load bearing joints. The mechanical and molecular mechanisms contributing to synovial joint pain are reviewed using two examples, the cervical spinal facet joints and the temporomandibular joint (TMJ). Although much work has focused on the macroscale mechanics of joints in health and disease, the combined influence of tissue mechanics, molecular processes, and nociception in joint pain has only recently become a focus...
February 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27981257/assessing-the-efficacy-of-vaginal-hyoscine-butyl-bromide-on-cervical-ripening-prior-to-intrauterine-procedures-a-double-blinded-clinical-trial
#13
Shiva Hadadian, Masoumeh Fallahian
BACKGROUND: Unripe cervix prevents entering the endometrial cavity during intrauterine procedures. Mechanical dilatation of cervical canal might cause undesirable complications. OBJECTIVE: To investigate the substitute of mechanical intervention with chemical treatment by administering hyoscine to patients. MATERIALS AND METHODS: Sixty non-pregnant women, 20-70 years of age, with a closed cervix who were scheduled for an intrauterine procedure, were randomly divided into two groups...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27796368/targeting-non-classical-myelin-epitopes-to-treat-experimental-autoimmune-encephalomyelitis
#14
Xiaohua Wang, Jintao Zhang, David J Baylink, Chih-Huang Li, Douglas M Watts, Yi Xu, Xuezhong Qin, Michael H Walter, Xiaolei Tang
Qa-1 epitopes, the peptides that bind to non-classical major histocompatibility complex Ib Qa-1 molecules and are recognized by Qa-1-restricted CD8(+) regulatory T (Treg) cells, have been identified in pathogenic autoimmune cells that attack myelin sheath in experimental autoimmune encephalomyelitis (EAE, an animal model for multiple sclerosis [MS]). Additionally, immunization with such epitopes ameliorates the EAE. However, identification of such epitopes requires knowledge of the pathogenic autoimmune cells which are largely unknown in MS patients...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27697286/the-effect-of-transplanted-human-wharton-s-jelly-mesenchymal-stem-cells-treated-with-ifn-%C3%AE-on-experimental-autoimmune-encephalomyelitis-mice
#15
Mohammad Torkaman, Marzieh Ghollasi, Mousa Mohammadnia-Afrouzi, Ali Salimi, Afshin Amari
Interferon gamma (IFN-γ) increases the immunosuppressive property of human Wharton's jelly mesenchymal stem cells (hWJ-MSCs). In this study, we evaluated the therapeutic effects of IFN-γ primed WJ-MSCs in EAE mice. IFN-γ primed WJ-MSCs were injected on days 3 and 11 after EAE induction. 21 days after EAE induction, splenocytes and cervical lymph node cells were isolated and cell proliferation, secretion of inflammatory cytokines and frequency of regulatory T-cells was measured. On day 50 of the study, cell infiltration and gene expression of inflammatory cytokines in brain of mice were studied...
January 2017: Cellular Immunology
https://www.readbyqxmd.com/read/27679244/cervical-priming-prior-to-operative-hysteroscopy-a-randomized-controlled-study-comparing-the-efficacy-of-laminaria-versus-evening-primrose-oil-epo
#16
Mlc Tanchoco, A S Aguilar
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27676456/induction-of-mucosal-immune-responses-against-helicobacter-pylori-infection-after-sublingual-and-intragastric-route-of-immunization
#17
Louise Sjökvist Ottsjö, Frida Jeverstam, Linda Yrlid, Alexander U Wenzel, Anna K Walduck, Sukanya Raghavan
There is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against Helicobacter pylori, which causes a chronic infection that can lead to peptic ulcers and gastric cancer in a subpopulation of infected individuals. Mucosal CD4(+) T-cell responses have been shown to be essential for vaccine-induced protection against H. pylori infection. The current study addresses the influence of the adjuvant and site of mucosal immunization on early CD4(+) T-cell priming to H...
February 2017: Immunology
https://www.readbyqxmd.com/read/27660411/the-use-of-misoprostol-for-cervical-priming-prior-to-hysteroscopy-a-systematic-review-and-analysis
#18
Ying Hua, Wenwen Zhang, Xiaoli Hu, Ansu Yang, Xueqiong Zhu
The effects of misoprostol use on cervical priming prior to hysteroscopy have been controversial. Therefore, a systematic literature review and meta-analysis of studies were conducted to assess the effect of misoprostol on cervical priming prior to hysteroscopy. All studies published before July 2014 with data related to the use of misoprostol for cervical priming compared with placebo or no medication prior to hysteroscopy, were identified. Twenty-five randomized controlled trials involving 2,203 females were systematically analyzed...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27621024/industry-academic-partnerships-an-approach-to-accelerate-innovation
#19
Jennwood Chen, Timothy Pickett, Ashley Langell, Ashley Trane, Brian Charlesworth, Kris Loken, Sarah Lombardo, John T Langell
BACKGROUND: Biotechnology companies are process-driven organizations and often struggle with their ability to innovate. Universities, on the other hand, thrive on discovery and variation as a source of innovation. As such, properly structured academic-industry partnerships in medical technology development may enhance and accelerate innovation. Through joint industry-academic efforts, our objective was to develop a technology aimed at global cervical cancer prevention. METHODS: Our Center for Medical Innovation assembled a multidisciplinary team of students, surgical residents, and clinical faculty to enter in the University of Utah's annual Bench-to-Bedside competition...
September 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27566696/randomized-double-blind-placebo-controlled-study-of-preinduction-cervical-priming-with-25%C3%A2-%C3%A2%C2%B5g-of-misoprostol-in-the-outpatient-setting-to-prevent-formal-induction-of-labour
#20
Jameela PonMalar, Santosh Joseph Benjamin, Anuja Abraham, Swati Rathore, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
OBJECTIVE: To compare the efficacy of preinduction outpatient use of a single dose of 25 μg vaginal misoprostol between 38(1/2) and 40 weeks with that of placebo, to decrease the interval from intervention to delivery after stretch and sweep in low-risk gravid women with Bishop's score <4. METHOD: Sixty three women received 25 μg vaginal misoprostol and 63 women received placebo after stretch and sweep. RESULTS: The duration from intervention to delivery was 3...
August 26, 2016: Archives of Gynecology and Obstetrics
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