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cervical priming

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https://www.readbyqxmd.com/read/29708858/how-does-infection-with-human-papillomavirus-16-and-18-impact-on-dna-damage-and-repair-in-cervical-cells-and-peripheral-blood
#1
Eren Ozcagli, Aydan Biri, Bedia Dinc, Semra Sardas
Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide and a prime cause of cervical cancer. The HPV DNA is detected in approximately 80-90% of all cervical cancers, with HPV 16 and 18 being the high risk conferring human carcinogens. DNA damage and diminished DNA repair mechanisms are potential biological surrogates of HPV infection that warrant further research in different tissues and populations. Notably, we do not know the extent to which the high risk HPV 16 and 18 differentially affect cervical cells versus other systems such as peripheral blood lymphocytes (PBLs)...
April 30, 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29676975/eighteen-month-clinical-study-of-universal-adhesives-in-noncarious-cervical-lesions
#2
V C Ruschel, S Shibata, S C Stolf, Y Chung, L N Baratieri, H O Heymann, R Walter
OBJECTIVE: To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). METHODS AND MATERIALS: This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29624947/the-need-for-societal-investment-to-improve-cervical-cancer-outcomes-in-nigeria-a-commentary
#3
Jonah Musa
Although cervical cancer is a preventable cancer with a well-known natural history, it remains a huge burden in developing countries of sub-Saharan Africa where organized cervical cancer screening services are lacking. Developed countries that have invested on providing organized screening programs have made substantial progress in reducing both incidence and mortality due to cervical cancer. Implementing evidence-based interventions such as human papillomavirus (HPV) vaccination of young girls, early detection and treatment of premalignant conditions of the cervix through conventional Pap cytology, HPV screening or visual aided inspection with acetic acid could significantly reduce incidence of new cases at population level...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29593032/extracellular-conformational-changes-in-the-capsid-of-human-papillomaviruses-contribute-to-asynchronous-uptake-into-host-cells
#4
Miriam Becker, Lilo Greune, M Alexander Schmidt, Mario Schelhaas
The human papillomavirus type 16 (HPV16) is the leading cause of cervical cancer. For initial infection, HPV16 utilizes a novel endocytic pathway for host cell entry. Unique amongst viruses, uptake occurs asynchronously over a protracted period of time with half-times between 9-12 h. To trigger endocytic uptake, the virus particles need to undergo a series of structural modifications after initial binding to heparan sulfate proteoglycans (HSPG). These changes involve proteolytic cleavage of the major capsid protein L1 by kallikrein-8 (KLK8), exposure of the N-terminus of the minor capsid protein L2 by cyclophilins, and cleavage of this N-terminus by furin...
March 28, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29516923/immunohistochemical-evaluation-of-prime-molecules-in-cervical-lesions-towards-assessment-of-malignant-potentiality
#5
Lopamudra Das, Sukla Naskar, Tandra Sarkar, Ashok Kumar Maiti, Soumen Das, Jyotirmoy Chatterjee
Objective: A comparative immunohistochemical evaluation of p63, CD105, and E-cadherin expression pattern in histopathologically confirmed normal cervical epithelium (NCM), dysplastic cervical epithelium (DYS) and squamous cell carcinoma (SCC) of uterine cervix towards assessing malignant potentiality of the precancerous condition. Materials and Methods: The biopsies from cervical mucosa (normal, dysplasia, and cancer) were studied by routine hematoxylin and eosin (H and E) and by immunohistochemistry for p63, E-cadherin, and CD105 expression...
January 2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29456916/spine-degenerative-conditions-and-their-treatments-national-trends-in-the-united-states-of-america
#6
Zorica Buser, Brandon Ortega, Anthony D'Oro, William Pannell, Jeremiah R Cohen, Justin Wang, Ray Golish, Michael Reed, Jeffrey C Wang
Study Design: Retrospective database study. Objective: Low back and neck pain are among the top leading causes of disability worldwide. The aim of our study was to report the current trends on spine degenerative disorders and their treatments. Methods: Patients diagnosed with lumbar or cervical spine conditions within the orthopedic subset of Medicare and Humana databases (PearlDiver). From the initial cohorts we identified subgroups based on the treatment: fusion or nonoperative within 1 year from diagnosis...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29446090/potential-lives-saved-in-73-countries-by-adopting-multi-cohort-vaccination-of-9-14-year-old-girls-against-human-papillomavirus
#7
Mark Jit, Marc Brisson
Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high-income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vaccine introduction. We used the mathematical model PRIME to project the incremental impact of vaccinating 10- to 14-year-old girls compared to routine HPV vaccination only in the same year that routine vaccination is expected to be introduced for 9-year-old girls across 73 low- and lower-middle-income countries...
February 15, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29414299/predicting-falls-in-multiple-sclerosis-do-electrophysiological-measures-have-a-better-predictive-accuracy-compared-to-clinical-measures
#8
Somasundaram Aadhimoolam Chinnadurai, Divya Gandhirajan, Avathvadi Venkatesan Srinivasan, Bhanu Kesavamurthy, Lakshmi Narasimhan Ranganathan, Vijaya Pamidimukkala
BACKGROUND: The risk of falls in people with Multiple Sclerosis (MS) is much greater than that of the general population due to impaired coordination, gait, sensation, muscle tone, strength, and cognition. These MS related falls hamper the day to day living of these individuals and are one of the prime factors aggravating the disease related morbidity. The fear of falling itself may make these individuals more dependent and hinder their professional and leisurely activities. Hence, the significance of identifying individuals who are at risk of falling and instituting preventive counter-measures cannot be overemphasized...
February 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29409965/optimal-dose-of-vaginal-misoprostol-for-cervical-ripening-before-hysteroscopy-a-randomized-double-blind-study
#9
Ji Young Hwang, Seung Hun Song
STUDY OBJECTIVE: To evaluate the optimal dose of vaginal misoprostol (200 and 400 µg) for cervical priming before operative hysteroscopy. DESIGN: A randomized, controlled, double-blind trial (Canadian Task Force classification I). SETTING: A university hospital. PATIENTS: Sixty-eight patients undergoing operative hysteroscopy. INTERVENTIONS: Patients were randomized to receive a low (200 µg) or high (400 µg) dose of misoprostol administered vaginally 8 hours before operative hysteroscopy...
January 31, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29331266/human-papilloma-virus-specific-t-cells-can-be-generated-from-na%C3%A3-ve-t-cells-for-use-as-an-immunotherapeutic-strategy-for-immunocompromised-patients
#10
Sarah E McCormack, Conrad Russell Y Cruz, Kaylor E Wright, Allison B Powell, Haili Lang, Cornelia Trimble, Michael D Keller, Ephraim Fuchs, Catherine M Bollard
Human papilloma virus (HPV) is a known cause of cervical cancer, squamous cell carcinoma and laryngeal cancer. Although treatments exist for HPV-associated malignancies, patients unresponsive to these therapies have a poor prognosis. Recent findings from vaccine studies suggest that T-cell immunity is essential for disease control. Because Epstein-Barr Virus (EBV)-specific T cells have been highly successful in treating or preventing EBV-associated tumors, we hypothesized that the development of a manufacturing platform for HPV-specific T cells from healthy donors could be used in a third-party setting to treat patients with high-risk/relapsed HPV-associated cancers...
March 2018: Cytotherapy
https://www.readbyqxmd.com/read/29250974/moistening-the-new-vaginal-misoprostol-tablets-does-it-increase-the-efficacy-of-cervical-priming-before-manual-vacuum-aspiration-in-first-trimester-miscarriage-a-randomised-clinical-trial
#11
Ricardo Pedrini Cruz, Mariana Hollmann Scheffler, Daniel Mendes da Silva, Ernesto de Paula Guedes Neto, Ricardo Francalacci Savaris
OBJECTIVES: The primary objective of our study was to ascertain whether moistening the Brazilian formulation of vaginal misoprostol tablets increases cervical dilation before manual vacuum aspiration (MVA), compared with use of dry misoprostol, in first-trimester miscarriage. The secondary objective was to ascertain whether there was any correlation between vaginal pH and the degree of cervical dilation using a moistened or dry misoprostol tablet. METHODS: In a single-centre, double-blind, randomised trial, 46 patients with first-trimester miscarriage were randomly allocated to treatment with dry or moistened (with 200 µl distilled water) 2 × 200 μg misoprostol tablets...
December 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29179871/modulation-of-antigen-presenting-cell-functions-during-chronic-hpv-infection
#12
REVIEW
Abate Assefa Bashaw, Graham R Leggatt, Janin Chandra, Zewen K Tuong, Ian H Frazer
High-risk human papillomaviruses (HR-HPV) infect basal keratinocytes, where in some individuals they evade host immune responses and persist. Persistent HR-HPV infection of the cervix causes precancerous neoplasia that can eventuate in cervical cancer. Dendritic cells (DCs) are efficient in priming/cross-priming antigen-specific T cells and generating antiviral and antitumor cytotoxic CD8+ T cells. However, HR-HPV have adopted various immunosuppressive strategies, with modulation of DC function crucial to escape from the host adaptive immune response...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29159802/adenovirus-vector-based-prime-boost-vaccination-via-heterologous-routes-induces-cervicovaginal-cd8-t-cell-responses-against-hpv16-oncoproteins
#13
Nicolas Çuburu, Selina Khan, Cynthia D Thompson, Rina Kim, Jort Vellinga, Roland Zahn, Douglas R Lowy, Gert Scheper, John T Schiller
Recent advances in immunotherapy against cancer underscore the importance of T lymphocytes and tumor microenvironment, but few vaccines targeting cancer have been approved likely due in part to the dearth of common tumor antigens, insufficient immunogenicity and the evolution of immune evasion mechanisms during the progression to malignancy. Human papillomaviruses (HPVs) are the primary etiologic agents of cervical cancer and progression from persistent HPV-infection to cervical intraepithelial lesions and eventually cancer requires persistent expression of the oncoproteins E6 and E7...
April 1, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28990426/gene-therapy-for-modulation-of-t-cell-mediated-immune-response-provoked-by-corneal-transplantation
#14
Marko Pastak, Veronika Kleff, Daniel R Saban, Marta Czugala, Klaus-Peter Steuhl, Süleyman Ergün, Bernhard B Singer, Thomas A Fuchsluger
Corneal transplantation (keratoplasty) is the most common type of tissue replacement in the world. The increased rate of graft rejection after keratoplasty is a central problem for repeated transplantations and in inflamed host corneas. It has been shown that apoptosis of grafted epithelium has a role in corneal allograft rejection. This study focused on the T-cell response triggered in BALB/c mice after allogeneic corneal transplantation with and without anti-apoptotic p35-transduced epithelium. To restrict p35 expression to the epithelial cells, modified allogeneic composite grafts were created...
October 6, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28931676/protective-humoral-immunity-in-the-central-nervous-system-requires-peripheral-cd19-dependent-germinal-center-formation-following-coronavirus-encephalomyelitis
#15
Jeffrey R Atkinson, Cornelia C Bergmann
B cell subsets with phenotypes characteristic of naive, non-isotype-switched, memory (Bmem ) cells and antibody-secreting cells (ASC) accumulate in various models of central nervous system (CNS) inflammation, including viral encephalomyelitis. During neurotropic coronavirus JHMV infection, infiltration of protective ASC occurs after T cell-mediated viral control and is preceded by accumulation of non-isotype-switched IgD+ and IgM+ B cells. However, the contribution of peripheral activation events in cervical lymph nodes (CLN) to driving humoral immune responses in the infected CNS is poorly defined...
December 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28809390/clinical-features-and-surgical-outcomes-of-cervical-spondylotic-myelopathy-in-patients-of-different-ages-a-retrospective-study
#16
R J Zhang, C L Shen, J X Zhang, X J Zhang, F L Dong, H Tao, P W Song, P Ge, P Xu, H Q Zhang
STUDY DESIGN: Retrospective chart audit. OBJECTIVES: This study aims to compare the clinical features and surgical outcomes in patients with cervical spondylotic myelopathy (CSM) among different age groups. SETTING: The first Affiliated Hospital of Anhui Medical University, China. METHODS: A total of 460 patients with CSM who were surgically treated over the period of 1995-2009 were investigated. Considering the peak age (40-60 years old) for the onset of symptoms, we divided the patients into three groups by age: young (<40), middle-aged (40-60), and old (>60)...
January 2018: Spinal Cord
https://www.readbyqxmd.com/read/28781115/preferences-for-cervical-cancer-screening-the-role-of-implicit-associations
#17
Ida J Korfage, Erik W de Kwaadsteniet, Arno van Voorst, Anne M Stiggelbout, Marieke de Vries, Arwen H Pieterse
OBJECTIVES: Implicit associations influence behaviour, but their impact on cancer screening intentions is unknown. METHODS: We assessed implicit associations with cervical cancer screening using an evaluative priming task. Participants were shown primes ('Pap test', neutral or non-word) followed by positive or negative target words. The test is based on the assumption that response times are shorter if primes and targets are strongly associated in the participant's mind...
February 2018: Patient Education and Counseling
https://www.readbyqxmd.com/read/28725433/macrophage-type-2-differentiation-in-a-patient-with-laryngeal-squamous-cell-carcinoma-and-metastatic-prostate-adenocarcinoma-to-the-cervical-lymph-nodes
#18
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl
BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28720549/evolutionary-basis-of-a-new-gene-and-immune-therapeutic-approach-for-the-treatment-of-malignant-brain-tumors-from-mice-to-clinical-trials-for-glioma-patients
#19
Pedro R Lowenstein, Maria G Castro
Glioma cells are one of the most aggressive and malignant tumors. Following initial surgery, and radio-chemotherapy they progress rapidly, so that patients' median survival remains under two years. They invade throughout the brain, which makes them difficult to treat, and are universally lethal. Though total resection is always attempted it is not curative. Standard of care in 2016 comprises surgical resection, radiotherapy and chemotherapy (temozolomide). Median survival is currently ~14-20months post-diagnosis though it can be higher in high complexity medical university centers, or during clinical trials...
April 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28716144/macrophage-type-2-differentiation-in-a-patient-with-laryngeal-squamous-cell-carcinoma-and-metastatic-prostate-adenocarcinoma-to-the-cervical-lymph-nodes
#20
Michael C Topf, Madalina Tuluc, Larry A Harshyne, Adam Luginbuhl
BACKGROUND: The tumor microenvironment often polarizes infiltrating macrophages towards a type 2, or M2 phenotype, that is characterized by expression of various cysteine-rich, scavenger receptors, including CD163. The primary function of M2 macrophages is to facilitate wound healing. As such, they are capable of providing metabolic support to a growing tumor, neovascularization, as well as protection from cytotoxic T cells. The tumor microenvironment contains a milieu of secreted factors and vesicles, which in certain circumstances can gain access to lymphatic vessels that drain to local lymph nodes...
July 18, 2017: Journal for Immunotherapy of Cancer
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