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https://www.readbyqxmd.com/read/28814342/septal-contributions-to-olfactory-bulb-interneuron-diversity-in-the-embryonic-mouse-telencephalon-role-of-the-homeobox-gene-gsx2
#1
Shenyue Qin, Stephanie M Ware, Ronald R Waclaw, Kenneth Campbell
BACKGROUND: Olfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL). Although previous studies have attempted to investigate regional contributions to OB interneuron diversity, few genetic tools have been used to address this question at embryonic time points when the earliest populations are specified...
August 16, 2017: Neural Development
https://www.readbyqxmd.com/read/28808445/targeting-adult-neurogenesis-for-poststroke-therapy
#2
REVIEW
Jianfei Lu, Anatol Manaenko, Qin Hu
Adult neurogenesis mainly occurs at the subventricular zone (SVZ) on the walls of the lateral ventricle and the subgranular zone (SGZ) of the dentate gyrus (DG). However, the majority of newborn neurons undergo programmed cell death (PCD) during the period of proliferation, migration, and integration. Stroke activates neural stem cells (NSCs) in both SVZ and SGZ. This process is regulated by a wide variety of signaling pathways. However, the newborn neurons derived from adult neurogenesis are insufficient for tissue repair and function recovery...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28802192/soft-diet-feeding-impairs-neural-transmission-between-mitral-cells-and-interneurons-in-the-mouse-olfactory-bulb
#3
Tomohiro Noguchi, Chizuru Utsugi, Makoto Kashiwayanagi
(Objective) The subventricular zone in mice generates a lot of neuroblasts even during adulthood. These neuroblasts migrate to the olfactory bulb and differentiate into inhibitory interneurons such as granule cells and periglomerular cells. Olfactory sensory neurons receive information from various odorants and transmit it to the olfactory bulb. Our previous study showed that soft-diet feeding impairs neurogenesis in the subventricular zone, in turn leading to the reduction of odor-induced behaviors and Fos-immunoreactivities, the latter of which are markers of neural activity, at the olfactory bulb after exposure to odors...
July 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28801522/vascular-niche-contribution-to-age-associated-neural-stem-cell-dysfunction
#4
Deana Marie Apple, Erzsebet Kokovay
Neural stem cells (NSCs) persist throughout life in the dentate gyrus and the ventricular-subventricular zone (V-SVZ), where they continuously provide new neurons and some glia. These cells are found in specialized niches that regulate quiescence, activation, differentiation, and cell fate choice. A key aspect of the regulatory niche is the vascular plexus, which modulates NSC behavior during tissue homeostasis and regeneration. During aging, NSCs become depleted and dysfunctional, resulting in reduced neurogenesis and poor brain repair...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28801114/effects-of-curcumin-on-short-term-spatial-and-recognition-memory-adult-neurogenesis-and-neuroinflammation-in-a-streptozotocin-induced-rat-model-of-dementia-of-alzheimer-s-type
#5
Taysa B Bassani, Joelle M Turnes, Eric L R Moura, Jéssica M Bonato, Valentín Cóppola-Segovia, Silvio M Zanata, Rúbia M M W Oliveira, Maria A B F Vital
Curcumin is a natural polyphenol with evidence of antioxidant, anti-inflammatory and neuroprotective properties. Recent evidence also suggests that curcumin increases cognitive performance in animal models of dementia, and this effect would be related to its capacity to enhance adult neurogenesis. The aim of this study was to test the hypothesis that curcumin treatment would be able to preserve cognition by increasing neurogenesis and decreasing neuroinflammation in the model of dementia of Alzheimer's type induced by an intracerebroventricular injection of streptozotocin (ICV-STZ) in Wistar rats...
August 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28796246/identification-and-characterization-of-a-new-source-of-adult-human-neural-progenitors
#6
Jinan Behnan, Biljana Stangeland, Tiziana Langella, Gaetano Finocchiaro, Giovanni Tringali, Torstein R Meling, Wayne Murrell
Adult neural progenitor cells (aNPCs) are a potential source for cell based therapy for neurodegenerative diseases and traumatic brain injuries. These cells have been traditionally isolated from hippocampus, subventricular zone and white matter. However, there is still a need for an easily accessible source with better yield to counter the limitations of small surgical samples of previously characterized aNPCs. Here we show that ultrasonic aspirate (UA) samples currently considered as 'biological waste after surgery,' offer a good source for aNPCs...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28794445/igf-1-receptor-regulates-dynamic-changes-in-neuronal-polarity-during-cerebral-cortical-migration
#7
Álvaro F Nieto Guil, Mariana Oksdath, Linnea A Weiss, Diego J Grassi, Lucas J Sosa, Marta Nieto, Santiago Quiroga
During cortical development, neurons undergo polarization, oriented migration and layer-type differentiation. The biological and biochemical mechanisms underlying these processes are not completely understood. In neurons in culture we showed that IGF-1 receptor activation is important for growth cone assembly and axonal formation. However, the possible roles of the insulin like growth factor-1 receptor (IGF-1R) on neuronal differentiation and polarization in vivo in mammals have not yet been studied. Using in utero electroporation, we show here that the IGF-1R is essential for neocortical development...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28776186/home-sweet-home-the-neural-stem-cell-niche-throughout-development-and-after-injury
#8
REVIEW
Rebecca M Ruddy, Cindi M Morshead
Neural stem cells and their progeny reside in two distinct neurogenic niches within the mammalian brain: the subventricular zone and the dentate gyrus. The interplay between the neural stem cells and the niche in which they reside can have significant effects on cell kinetics and neurogenesis. A comprehensive understanding of the changes to the niche that occur through postnatal development and aging, as well as following injury, is relevant for developing therapeutics and interventions to promote neural repair...
August 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28766996/temporally-and-spatially-regulated-expression-of-the-linker-histone-h1fx-during-mouse-development
#9
Keiko Ichihara-Tanaka, Kenji Kadomatsu, Satoshi Kishida
The linker histone H1fx is the least characterized member of the H1 family. To investigate the developmental changes of H1fx, we performed an immunohistochemical analysis of its expression pattern from embryos to adult mice. We found that H1fx was highly expressed during gastrulation, and was positive in all embryonic germ layers between E8.5 and E10.5, which mostly overlapped with the expression of the proliferation marker Ki-67. Neural and mesenchyme tissues strongly expressed H1fx at E10.5. H1fx expression began to be restricted at around E12...
August 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/28755056/high-resolution-post-mortem-mri-of-non-fixed-in-situ-foetal-brain-in-the-second-trimester-of-gestation-normal-foetal-brain-development
#10
Elisa Scola, Giorgio Conte, Giovanni Palumbo, Sabrina Avignone, Claudia Maria Cinnante, Simona Boito, Nicola Persico, Tommaso Rizzuti, Fabio Triulzi
PURPOSE: To describe normal foetal brain development with high resolution post-mortem MRI (PMMRI) of non-fixed foetal brains. METHODS: We retrospectively collected PMMRIs of foetuses without intracranial abnormalities and chromosomal aberrations studied after a termination of pregnancy due to extracranial abnormalities or after a spontaneous intrauterine death. PMMRIs were performed on a 3-T scanner without any fixation and without removing the brain from the skull...
July 28, 2017: European Radiology
https://www.readbyqxmd.com/read/28746827/monocyte-depletion-early-after-stroke-promotes-neurogenesis-from-endogenous-neural-stem-cells-in-adult-brain
#11
Cecilia Laterza, Somsak Wattananit, Naomi Uoshima, Ruimin Ge, Roy Pekny, Daniel Tornero, Emanuela Monni, Olle Lindvall, Zaal Kokaia
Ischemic stroke, caused by middle cerebral artery occlusion, leads to long-lasting formation of new striatal neurons from neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of adult rodents. Concomitantly with this neurogenic response, SVZ exhibits activation of resident microglia and infiltrating monocytes. Here we show that depletion of circulating monocytes, using the anti-CCR2 antibody MC-21 during the first week after stroke, enhances striatal neurogenesis at one week post-insult, most likely by increasing short-term survival of the newly formed neuroblasts in the SVZ and adjacent striatum...
July 23, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28744915/characterization-of-glcci1-expression-in-a-subpopulation-of-lateral-ganglionic-eminence-progenitors-in-the-mouse-telencephalon
#12
Vikram Kohli, Diana Nardini, Lisa A Ehrman, Ronald R Waclaw
The lateral ganglionic eminence (LGE) in the ventral telencephalon is a diverse progenitor domain subdivided by distinct gene expression into a dorsal region (dLGE) that gives rise to olfactory bulb and amygdalar interneurons and a ventral region (vLGE) that gives rise to striatal projection neurons. The homeobox gene, Gsx2, is an enriched marker of the LGE and is expressed in a high dorsal to low ventral gradient in the ventricular zone (VZ) as development proceeds. Aside from Gsx2, markers restricted to the VZ in the dorsal and/or ventral LGE remain largely unknown...
July 26, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28743634/early-ciliary-and-prominin-1-dysfunctions-precede-neurogenesis-impairment-in-a-mouse-model-of-type-2-diabetes
#13
Tomás P Bachor, Jana Karbanová, Edgar Büttner, Vicente Bermúdez, Melisa Marquioni-Ramella, Peter Carmeliet, Denis Corbeil, Angela M Suburo
Diabetes mellitus (DM) is reaching epidemic conditions worldwide and increases the risk for cognition impairment and dementia. Here, we postulated that progenitors in adult neurogenic niches might be particularly vulnerable. Therefore, we evaluated the different components of the mouse subventricular zone (SVZ) during the first week after chemical induction of type 1 and type 2 diabetes-like (T1DM and T2DM) conditions. Surprisingly, only T2DM mice showed SVZ damage. The initial lesions were localized to ependymal cilia, which appeared disorientated and clumped together...
July 23, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28739678/meis-homeodomain-proteins-facilitate-parp1-artd1-mediated-eviction-of-histone-h1
#14
Ann-Christin Hau, Britta Moyo Grebbin, Zsuzsa Agoston, Marie Anders-Maurer, Tamara Müller, Anja Groß, Jasmine Kolb, Julian D Langer, Claudia Döring, Dorothea Schulte
Pre-B-cell leukemia homeobox (PBX) and myeloid ecotropic viral integration site (MEIS) proteins control cell fate decisions in many physiological and pathophysiological contexts, but how these proteins function mechanistically remains poorly defined. Focusing on the first hours of neuronal differentiation of adult subventricular zone-derived stem/progenitor cells, we describe a sequence of events by which PBX-MEIS facilitates chromatin accessibility of transcriptionally inactive genes: In undifferentiated cells, PBX1 is bound to the H1-compacted promoter/proximal enhancer of the neuron-specific gene doublecortin (Dcx) Once differentiation is induced, MEIS associates with chromatin-bound PBX1, recruits PARP1/ARTD1, and initiates PARP1-mediated eviction of H1 from the chromatin fiber...
July 24, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28738875/effects-of-fty720-on-brain-neurogenic-niches-in-vitro-and-after-kainic-acid-induced-injury
#15
Raffaela Cipriani, Juan Carlos Chara, Alfredo Rodríguez-Antigüedad, Carlos Matute
BACKGROUND: FTY720 (fingolimod, Gilenya™) is an oral, blood-brain barrier (BBB)-passing drug approved as immunomodulatory treatment for relapsing-remitting form of the multiple sclerosis (MS). In addition, FTY720 exerts several effects in the central nervous system (CNS), ranging from neuroprotection to reduction of neuroinflammation. However, the neurogenic and oligodendrogenic potential of FTY720 has been poorly investigated. In this study, we assessed the effect of FTY720 on the production of new neurons and oligodendrocytes from neural stem/precursor cells both in vitro and in vivo...
July 24, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28738501/inhibition-of-glycogen-synthase-kinase-3-increased-subventricular-zone-stem-cells-proliferation
#16
Narges Pachenari, Sahar Kiani, Mohammad Javan
The effects of Wnt signaling modifiers on cell proliferation, seem to be cell specific. Enhancing the proliferation of subventricular zone (SVZ) progenitors has been in the focus of research in recent years. Here we investigate the effect of CHIR99021, a Glycogen Synthase Kinase 3 (GSk-3) inhibitor, on SVZ progenitor's proliferation both in vivo and in vitro. Neural stem cells were extracted from the adult C57bl/6 by mincing and trypsin treatment followed by culturing in specific medium. Sphere cells formed within about 7-10days and were characterized by immunostaining...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28733832/seasonal-reorganization-of-hypothalamic-neurogenic-niche-in-adult-sheep
#17
Lucile Butruille, Martine Batailler, Danièle Mazur, Vincent Prévot, Martine Migaud
Neurogenesis is the process by which new neurons are generated. This process, well established during development, persists in adulthood owing to the presence of neural stem cells (NSCs) localized in specific brain areas called neurogenic niches. Adult neurogenesis has recently been shown to occur in the hypothalamus, a structure involved in the neuroendocrine regulation of reproduction and metabolism, among others. In the adult sheep-a long-lived mammalian model-we have previously reported the existence of such a neurogenic niche located in the hypothalamic arcuate nucleus and the median eminence...
July 21, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28728023/persistent-expression-of-vcam1-in-radial-glial-cells-is-required-for-the-embryonic-origin-of-postnatal-neural-stem-cells
#18
Xiao-Ling Hu, Guo Chen, Sanguo Zhang, Jiangli Zheng, Jun Wu, Qing-Ran Bai, Yue Wang, Ji Li, Huanhuan Wang, Han Feng, Jia Li, Xicai Sun, Qijun Xia, Fan Yang, Jing Hang, Chang Qi, Timothy N Phoenix, Sally Temple, Qin Shen
During development, neural stem cells (NSCs) undergo transitions from neuroepithelial cells to radial glial cells (RGCs), and later, a subpopulation of slowly dividing RGCs gives rise to the quiescent adult NSCs that populate the ventricular-subventricular zone (V-SVZ). Here we show that VCAM1, a transmembrane protein previously found in quiescent adult NSCs, is expressed by a subpopulation of embryonic RGCs, in a temporal and region-specific manner. Loss of VCAM1 reduced the number of active embryonic RGCs by stimulating their premature neuronal differentiation while preventing quiescence in the slowly dividing RGCs...
July 19, 2017: Neuron
https://www.readbyqxmd.com/read/28725659/explant-methodology-for-analyzing-neuroblast-migration
#19
Kirsty J Dixon, Alisa Turbic, Ann M Turnley, Daniel J Liebl
The subventricular zone (SVZ) in the mammalian forebrain contains stem/progenitor cells that migrate through the rostral migratory stream (RMS) to the olfactory bulb throughout adulthood. SVZ-derived explant cultures provide a convenient method to assess factors regulating the intermediary stage of neural stem/progenitor cell migration. Here, we describe the isolation of SVZ-derived RMS explants from the neonatal mouse brain, and the conditions required to culture and evaluate their migration.
May 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28716558/emmprin-overexpression-in-svz-neural-progenitor-cells-increases-their-migration-towards-ischemic-cortex
#20
Michiko Kanemitsu, Oleg Tsupykov, Gaël Potter, Michael Boitard, Patrick Salmon, Eloisa Zgraggen, Eduardo Gascon, Galina Skibo, Alexandre G Dayer, Jozsef Z Kiss
Stimulation of endogenous neurogenesis and recruitment of neural progenitors from the subventricular zone (SVZ) neurogenic site may represent a useful strategy to improve regeneration in the ischemic cortex. Here, we tested whether transgenic overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN), the regulator of matrix metalloproteinases (MMPs) expression, in endogenous neural progenitor cells (NPCs) in the subventricular zone (SVZ) could increase migration towards ischemic injury. For this purpose, we applied a lentivector-mediated gene transfer system...
July 14, 2017: Experimental Neurology
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