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Subventricular zone

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https://www.readbyqxmd.com/read/29230807/a-comparative-study-of-the-neural-stem-cell-niche-in-the-adult-hypothalamus-of-human-mouse-rat-and-grey-mouse-lemur-microcebus-murinus
#1
Giuliana Pellegrino, Claire Trubert, Jérémy Terrien, Fabien Pifferi, Danièle Leroy, Anne Loyens, Martine Migaud, Marc Baroncini, Claude-Alain Maurage, Christian Fontaine, Vincent Prévot, Ariane Sharif
The adult brain contains niches of neural stem cells that continuously add new neurons to selected circuits throughout life. Two niches have been extensively studied in various mammalian species including humans, the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. Recently, studies conducted mainly in rodents have identified a third neurogenic niche in the adult hypothalamus. In order to evaluate whether a neural stem cell niche also exists in the adult hypothalamus in humans, we performed multiple immunofluorescence labeling to assess the expression of a panel of neural stem/progenitor cell (NPC) markers (Sox2, nestin, vimentin, GLAST, GFAP) in the human hypothalamus and compared them with the mouse, rat and a non-human primate species, the grey mouse lemur (Microcebus murinus)...
December 12, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29228390/altered-brain-morphology-after-focal-radiation-reveals-impact-of-off-target-effects-implications-for-white-matter-development-and-neurogenesis
#2
Kiran G Beera, Yu-Qing Li, Jun Dazai, James Stewart, Shannon Egan, Mashal Ahmed, C Shun Wong, David A Jaffray, Brian J Nieman
Background: Children with brain tumors treated with cranial radiation therapy (RT) often exhibit cognitive late effects, commonly associated with reduced white matter (WM) volume and decreased neurogenesis. The impact of radiation damage in particular regions or tissues on brain development as a whole has not been elucidated. Methods: We delivered whole-brain or focal radiation (8 Gy single dose) to infant mice. Focal treatments targeted white matter (anterior commissure), neuronal (olfactory bulbs), or neurogenic (subventricular zone) regions...
November 2, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29207629/genetic-deletion-of-rnd3-in-neural-stem-cells-promotes-proliferation-via-upregulation-of-notch-signaling
#3
Huimin Dong, Xi Lin, Yuntao Li, Ronghua Hu, Yang Xu, Xiaojie Guo, Qiong La, Shun Wang, Congcong Fang, Junli Guo, Qi Li, Shanping Mao, Baohui Liu
Rnd3, a Rho GTPase, is involved in the inhibition of actin cytoskeleton dynamics through the Rho kinase-dependent signaling pathway. We previously demonstrated that mice with genetic deletion of Rnd3 developed a markedly larger brain compared with wild-type mice. Here, we demonstrate that Rnd3 knockout mice developed an enlarged subventricular zone, and we identify a novel role for Rnd3 as an inhibitor of Notch signaling in neural stem cells. Rnd3 deficiency, both in vivo and in vitro, resulted in increased levels of Notch intracellular domain protein...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205371/characterization-of-the-canine-rostral-ventricular-subventricular-zone-morphological-immunohistochemical-ultrastructural-and-neurosphere-assay-studies
#4
Francisco Fernández-Flores, José Manuel García-Verdugo, Raquel Martín-Ibáñez, Cristina Herranz, Dolors Fondevila, Josep María Canals, Carles Arús, Martí Pumarola
The mammalian ventricular-subventricular zone (V-SVZ) presents the highest neurogenic potential in the brain of the adult individual. In rodents, it is mainly composed of chains of neuroblasts. In humans, it is organized in layers where neuroblasts do not form chains. The aim of this study is to describe the cytoarchitecture of canine V-SVZ (cV-SVZ), to assess its neurogenic potential, and to compare our results with those previously described in other species. We have studied by histology, immunohistochemistry (IHC), electron microscopy and neurosphere assay the morphology, cytoarchitecture and neurogenic potential of cV-SVZ...
December 4, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/29205011/clinical-correlates-of-subventricular-zone-contacting-glioblastomas-a-meta-analysis
#5
Akshitkumar M Mistry
INTRODUCTION: The clinical and molecular correlates of glioblastomas (GBMs) contacting the subventricular zone (SVZ+ GBM) are unknown. We aimed to reveal any such correlates that may help explain their increased GBM malignancy. EVIDENCE ACQUISITION: A meta-analysis was, therefore, conducted to assess whether tumor's MGMT promoter methylation status, IDH mutation status, volume, and extent of resection as well as patients' age at diagnosis and preoperative Karnofsky performance status score (KPS) correlate with SVZ contact by GBM...
December 4, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29204012/use-of-preoperative-ependymal-enhancement-on-magnetic-resonance-imaging-brain-as-a-marker-of-grade-of-glioma
#6
Sumit Sharma, Shashi Kant Jain, Virendra Deo Sinha
Objectives: Neural stem cells within the subventricular zone (SVZ) are thought to be responsible for the origin and the heterogeneous nature of the gliomas. The relationship of the gliomas to the SVZ can be appreciated as ependymal enhancement on contrast magnetic resonance imaging (MRI). This study evaluates the rate of ependymal enhancement and its association with the histopathological grade of gliomas. Patients and Methods: Seventy-five patients with radiological features of glioma were recruited...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29180821/specific-features-of-svz-neurogenesis-after-cortical-ischemia-a-longitudinal-study
#7
S Palma-Tortosa, A García-Culebras, A Moraga, O Hurtado, A Perez-Ruiz, V Durán-Laforet, J de la Parra, M I Cuartero, J M Pradillo, M A Moro, I Lizasoain
Stroke is a devastating disease with an increasing prevalence. Part of the current development in stroke therapy is focused in the chronic phase, where neurorepair mechanisms such as neurogenesis, are involved. In the adult brain, one of the regions where neurogenesis takes place is the subventricular zone (SVZ) of the lateral ventricles. Given the possibility to develop pharmacological therapies to stimulate this process, we have performed a longitudinal analysis of neurogenesis in a model of cortical ischemia in mice...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29174383/intracerebroventricular-streptozotocin-impairs-adult-neurogenesis-and-cognitive-functions-via-regulating-neuroinflammation-and-insulin-signaling-in-adult-rats
#8
Sandeep Kumar Mishra, Sonu Singh, Shubha Shukla, Rakesh Shukla
Neurogenesis is a complex process involved in memory formation and is known to be altered in Alzheimer's disease (AD). Neuroinflammation and insulin signaling dysfunction, key players during intracerebroventricular Streptozotocin (ICV-STZ) induced dementia variedly affects neurogenesis. The aim of this work was to study the variation in neurogenic process associated with AD in ICV STZ induced dementia. Adult male Sprague Dawley rats weighing 180-200 g were given two different doses of ICV STZ (3 mg/kg on Day 1 and 3, & 1 mg/kg on Day 1) in two different experimental setup...
November 21, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29163067/the-baf45d-protein-is-preferentially-expressed-in-adult-neurogenic-zones-and-in-neurons-and-may-be-required-for-retinoid-acid-induced-pax6-expression
#9
Chao Liu, Ruyu Sun, Jian Huang, Dijuan Zhang, Dake Huang, Weiqin Qi, Shenghua Wang, Fenfen Xie, Yuxian Shen, Cailiang Shen
Adult neurogenesis is important for the development of regenerative therapies for human diseases of the central nervous system (CNS) through the recruitment of adult neural stem cells (NSCs). NSCs are characterized by the capacity to generate neurons, astrocytes, and oligodendrocytes. To identify key factors involved in manipulating the adult NSC neurogenic fate thus has crucial implications for the clinical application. Here, we report that BAF45D is expressed in the subgranular zone (SGZ) of the dentate gyrus, the subventricular zone (SVZ) of the lateral ventricle, and the central canal (CC) of the adult spinal cord...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29162133/humoral-response-in-experimental-autoimmune-encephalomyelitis-targets-neural-precursor-cells-in-the-central-nervous-system-of-naive-rodents
#10
Evangelia Kesidou, Olga Touloumi, Roza Lagoudaki, Evangelia Nousiopoulou, Paschalis Theotokis, Kyriaki-Nepheli Poulatsidou, Marina Boziki, Evangelia Kofidou, Nickoleta Delivanoglou, Fani Minti, Georgios Hadjigeorgiou, Nikolaos Grigoriadis, Constantina Simeonidou
BACKGROUND: Neural precursor cells (NPCs) located in the subventricular zone (SVZ), a well-defined NPC niche, play a crucial role in central nervous system (CNS) homeostasis. Moreover, NPCs are involved in the endogenous reparative process both in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, the possibility that NPCs may be vulnerable to immune-related components may not be ruled out. Therefore, we investigated the potential affinity of myelin oligodendrocyte glycoprotein (MOG)-induced humoral response(s) to NPCs...
November 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29154990/exosomes-derived-from-human-umbilical-vein-endothelial-cells-promote-neural-stem-cell-expansion-while-maintain-their-stemness-in-culture
#11
Yi-Zhe Zhang, Fan Liu, Chang-Geng Song, Xiu-Li Cao, Yu-Fei Zhang, Hai-Ning Wu, Chen-Jun Guo, Yong-Qiang Li, Qi-Jun Zheng, Min-Hua Zheng, Hua Han
The neural stem cell (NSC) niche in subventricular zone (SVZ) of adult mammalian brain contains dense vascular plexus, where endothelial cells (ECs) regulate NSCs by releasing plenty of angiocrine factors. However, the role of ECs-derived exosomes, a novel type of mediators of intercellular communications, in the regulation of NSCs remains unclear. In the current study, primary NSCs isolated from embryonic mouse brains form more neurospheres when cultured in the presence of human umbilical vein endothelial cells (HUVECs)...
November 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29153395/ultrasound-mediated-kallidinogenase-loaded-microbubble-targeted-therapy-for-acute-cerebral-infarction
#12
Yanling Liang, Jia Chen, Xuan Zheng, Zhiyi Chen, Yuming Liu, Siying Li, Xiaobo Fang
BACKGROUND: The neuroprotective effects of kallidinogenase against acute cerebral infarction have been demonstrated, and the use of microbubbles has been suggested as a therapeutic mechanism for drug delivery. This study was designed to investigate the optimal parameters for preparing kallidinogenase-loaded microbubbles (KLMs) and to evaluate the effects of KLM-targeted therapy on neurogenesis and angiogenesis following experimental acute cerebral infarction in rats. MATERIALS AND METHODS: KLMs were prepared by mechanical shaking...
November 15, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29150616/nmr-metabolomics-for-stem-cell-type-discrimination
#13
Franca Castiglione, Monica Ferro, Evangelos Mavroudakis, Rosalia Pellitteri, Patrizia Bossolasco, Damiano Zaccheo, Massimo Morbidelli, Vincenzo Silani, Andrea Mele, Davide Moscatelli, Lidia Cova
Cell metabolism is a key determinant factor for the pluripotency and fate commitment of Stem Cells (SCs) during development, ageing, pathological onset and progression. We derived and cultured selected subpopulations of rodent fetal, postnatal, adult Neural SCs (NSCs) and postnatal glial progenitors, Olfactory Ensheathing Cells (OECs), respectively from the subventricular zone (SVZ) and the olfactory bulb (OB). Cell lysates were analyzed by proton Nuclear Magnetic Resonance ((1)H-NMR) spectroscopy leading to metabolites identification and quantitation...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29141824/inhibition-of-neurogenesis-in-a-case-of-marburg-variant-multiple-sclerosis
#14
Celia Oreja-Guevara, Ulises Gómez-Pinedo, Julia García-López, Rafael Sánchez-Sánchez, Roberto Valverde-Moyano, Alberto Rabano-Gutierrez, Jordi A Matías-Guiu, Ines González-Suárez, Jorge Matías-Guiu
INTRODUCTION: Neural stem cells (NSC) are located essentially in the subventricular zone (SVZ), subgranular zone (SGZ), and along the central canal of the spinal cord. These cells can proliferate in vitro and differentiate into neurons, oligodendrocytes, and astroglia, thus contributing to repair in multiple sclerosis (MS). We conducted a pathological study to analyse neurogenic response in a patient with Marburg variant MS. METHODS: We present the case of a 27-year-old immunocompetent patient with Marburg variant MS, a fulminant form of the disease...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29132503/gyrification-of-the-cerebral-cortex-requires-fgf-signaling-in-the-mammalian-brain
#15
Naoyuki Matsumoto, Yohei Shinmyo, Yoshie Ichikawa, Hiroshi Kawasaki
Although it has been believed that the evolution of cortical folds was a milestone, allowing for an increase in the number of neurons in the cerebral cortex, the mechanisms underlying the formation of cortical folds are largely unknown. Here we show regional differences in the expression of fibroblast growth factor receptors (FGFRs) in the developing cerebral cortex of ferrets even before cortical folds are formed. By taking the advantage of our in utero electroporation technique for ferrets, we found that cortical folding was impaired in the ferret cerebral cortex when FGF signaling was inhibited...
November 14, 2017: ELife
https://www.readbyqxmd.com/read/29129683/non-monotonic-changes-in-progenitor-cell-behavior-and-gene-expression-during-aging-of-the-adult-v-svz-neural-stem-cell-niche
#16
Maria Apostolopoulou, Thomas R Kiehl, Mark Winter, Edgar Cardenas De La Hoz, Nathan C Boles, Christopher S Bjornsson, Kristen L Zuloaga, Susan K Goderie, Yue Wang, Andrew R Cohen, Sally Temple
Neural stem cell activity in the ventricular-subventricular zone (V-SVZ) decreases with aging, thought to occur by a unidirectional decline. However, by analyzing the V-SVZ transcriptome of male mice at 2, 6, 18, and 22 months, we found that most of the genes that change significantly over time show a reversal of trend, with a maximum or minimum expression at 18 months. In vivo, MASH1(+) progenitor cells decreased in number and proliferation between 2 and 18 months but increased between 18 and 22 months...
November 8, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29129682/spatial-and-sex-dependent-responses-of-adult-endogenous-neural-stem-cells-to-alcohol-consumption
#17
Erica L McGrath, Junling Gao, Yong-Fang Kuo, Tiffany J Dunn, Moniqua J Ray, Kelly T Dineley, Kathryn A Cunningham, Bhupendra S Kaphalia, Ping Wu
Chronic alcohol abuse results in alcohol-related neurodegeneration, and critical gaps in our knowledge hinder therapeutic development. Neural stem cells (NSCs) are a subpopulation of cells within the adult brain that contribute to brain maintenance and recovery. While it is known that alcohol alters NSCs, little is known about how NSC response to alcohol is related to sex, brain region, and stage of differentiation. Understanding these relationships will aid in therapeutic development. Here, we used an inducible transgenic mouse model to track the stages of differentiation of adult endogenous NSCs and observed distinct NSC behaviors in three brain regions (subventricular zone, subgranular zone, and tanycyte layer) after long-term alcohol consumption...
November 3, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29128167/a-prospective-evaluation-of-hippocampal-radiation-dose-volume-effects-and-memory-deficits-following-cranial-irradiation
#18
Ting Martin Ma, Jimm Grimm, Riley McIntyre, Heather Anderson-Keightly, Lawrence R Kleinberg, Russell K Hales, Joseph Moore, Tracy Vannorsdall, Kristin J Redmond
BACKGROUND AND PURPOSE: To prospectively evaluate hippocampal radiation dose volume effects and memory decline following cranial irradiation. MATERIAL AND METHODS: Effects of hippocampal radiation over a wide range of doses were investigated by combining data from three prospective studies. In one, adults with small cell lung cancer received hippocampal-avoidance prophylactic cranial irradiation. In the other two, adults with glioblastoma multiforme received neural progenitor cell sparing radiation or no sparing with extra dose delivered to subventricular zone...
November 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29126954/quantitative-analysis-of-kynurenine-aminotransferase-ii-in-the-adult-rat-brain-reveals-high-expression-in-proliferative-zones-and-corpus-callosum
#19
Chang Song, Sarah M Clark, Chloe N Vaughn, James D Nicholson, Kelley J Murphy, Ta-Chung M Mou, Robert Schwarcz, Gloria E Hoffman, Leonardo H Tonelli
Kynurenic acid, a metabolite of the kynurenine pathway of tryptophan degradation, acts as an endogenous antagonist of alpha7 nicotinic and NMDA receptors and is implicated in a number of neurophysiological and neuropathological processes including cognition and neurodegenerative events. Therefore, kynurenine aminotransferase II (KAT II/AADAT), the enzyme responsible for the formation of the majority of neuroactive kynurenic acid in the brain, has prompted significant interest. Using immunohistochemistry, this enzyme was localized primarily in astrocytes throughout the adult rat brain, but detailed neuroanatomical studies are lacking...
November 8, 2017: Neuroscience
https://www.readbyqxmd.com/read/29126932/docosahexaenoic-acid-dha-enhances-the-therapeutic-potential-of-neonatal-neural-stem-cell-transplantation-post-traumatic-brain-injury
#20
Hussein Ghazale, Naify Ramadan, Sara Mantash, Kazem Zibara, Sally El-Sitt, Hala Darwish, Farah Chamaa, Rose Mary Boustany, Stefania Mondello, Wassim Abou-Kheir, Jihane Soueid, Firas Kobeissy
Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide with 1.5 million people inflicted yearly. Several neurotherapeutic interventions have been proposed including drug administration as well as cellular therapy involving neural stem cells (NSCs). Among the proposed drugs is docosahexaenoic acid (DHA), a polyunsaturated fatty acid, exhibiting neuroprotective properties. In this study, we utilized an innovative intervention of neonatal NSCs transplantation in combination with DHA injections in order to ameliorate brain damage and promote functional recovery in an experimental model of TBI...
November 7, 2017: Behavioural Brain Research
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