keyword
MENU ▼
Read by QxMD icon Read
search

how

keyword
https://www.readbyqxmd.com/read/28651367/alternative-rna-splicing-associated-with-mammalian-neuronal-differentiation
#1
Jiancheng Liu, Anqi Geng, Xiwei Wu, Ren-Jang Lin, Qiang Lu
Alternative pre-mRNA splicing (AS) produces multiple isoforms of mRNAs and proteins from a single gene. It is most prevalent in the mammalian brain and is thought to contribute to the formation and/or maintenance of functional complexity of the brain. Increasing evidence has documented the significant changes of AS between different regions or different developmental stages of the brain, however, the dynamics of AS and the possible function of it during neural progenitor cell (NPC) differentiation is less well known...
June 23, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28651351/applying-a-theory-driven-framework-to-guide-quality-improvement-efforts-in-nursing-homes-the-lock-model
#2
Whitney L Mills, Camilla B Pimentel, Jennifer A Palmer, A Lynn Snow, Nancy J Wewiorski, Rebecca S Allen, Christine W Hartmann
Purpose of the Study: Implementing quality improvement (QI) programs in nursing homes continues to encounter significant challenges, despite recognized need. QI approaches provide nursing home staff with opportunities to collaborate on developing and testing strategies for improving care delivery. We present a theory-driven and user-friendly adaptable framework and facilitation package to overcome existing challenges and guide QI efforts in nursing homes. Design and development: The framework is grounded in the foundational concepts of strengths-based learning, observation, relationship-based teams, efficiency, and organizational learning...
June 23, 2017: Gerontologist
https://www.readbyqxmd.com/read/28651309/the-pattern-of-choosing-dialysis-modality-and-related-mortality-outcomes-in-korea-a-national-population-based-study
#3
Hyung Jong Kim, Jung Tak Park, Seung Hyeok Han, Tae-Hyun Yoo, Hyeong-Cheon Park, Shin-Wook Kang, Kyoung Hoon Kim, Dong-Ryeol Ryu, Hyunwook Kim
Background/Aims: Since comorbidities are major determinants of modality choice, and also interact with dialysis modality on mortality outcomes, we examined the pattern of modality choice according to comorbidities and then evaluated how such choices affected mortality in incident dialysis patients. Methods: We analyzed 32,280 incident dialysis patients in Korea. Patterns in initial dialysis choice were assessed by multivariate logistic regression analyses. Multivariate Poisson regression analyses were performed to evaluate the effects of interactions between comorbidities and dialysis modality on mortality and to quantify these interactions using the synergy factor...
June 26, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28651215/anticipatory-postural-adjustment-patterns-during-gait-initiation-across-the-adult-lifespan
#4
Chiahao Lu, Sommer L Amundsen Huffmaster, Jack C Harvey, Colum D MacKinnon
Gait initiation involves a complex sequence of anticipatory postural adjustments (APAs) during the transition from steady state standing to forward locomotion. APAs have four core components that function to accelerate the center of mass forwards and towards the initial single-support stance limb. These components include loading of the initial step leg, unloading of the initial stance leg, and excursion of the center of pressure in the posterior and lateral (towards the stepping leg) directions. This study examined the incidence, magnitude, and timing of these components and how they change across the lifespan (ages 20-79)...
June 16, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28651213/reward-related-frontostriatal-activity-and-smoking-behavior-among-adolescents-in-treatment-for-smoking-cessation
#5
Kathleen A Garrison, Sarah W Yip, Iris M Balodis, Kathleen M Carroll, Marc N Potenza, Suchitra Krishnan-Sarin
BACKGROUND: Tobacco use is often initiated during adolescence and continued into adulthood despite desires to quit. A better understanding of the neural correlates of abstinence from smoking in adolescents may inform more effective smoking cessation interventions. Neural reward systems are implicated in tobacco use disorder, and adolescent smokers have shown reduced reward-related ventral striatal activation related to increased smoking. METHODS: The current study evaluated nondrug reward anticipation in adolescent smokers using a monetary incentive delay task in fMRI pre- and post- smoking cessation treatment (n=14)...
June 3, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28651200/nanostructured-micro-raspberries-from-superparamagnetic-iron-oxide-nanoparticles-studying-agglomeration-degree-and-redispersibility-of-nanoparticulate-powders-via-magnetisation-measurements
#6
Claudia Stauch, Stephan Späth, Thomas Ballweg, Robert Luxenhofer, Karl Mandel
Surface modified superparamagnetic iron oxide nanoparticles are assembled into nanostructured micro-raspberry particles via spray drying. The micro-raspberry powder is readily redispersed to individual nanoparticles or nanostructured sub-units, depending on the initially adjusted nanoparticle modification. In this work, it is demonstrated how the technique of magnetic zero-field-cooled/field-cooled (ZFC/FC) measurements can be used to judge the degree of agglomeration, i.e. the extent of hard-agglomerates and soft-agglomerates in a system and predict the redispersibility of the powder particles...
June 16, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28651182/chronic-effects-of-atrazine-exposure-and-recovery-in-freshwater-benthic-diatoms-from-two-communities-with-different-pollution-histories
#7
Rebecca J Wood, Simon M Mitrovic, Richard P Lim, Ben J Kefford
Diffuse agricultural runoff into rivers can result in contamination with herbicides for prolonged periods of time. Chronic exposure to herbicides has the potential to alter toxic impacts in primary producers such as benthic diatoms. Determining how individual diatom taxa respond to herbicide exposure over varied exposure durations is essential for assessing herbicide impacts. This study investigated the responses of various benthic diatom taxa and effects at the community level over 12days of atrazine exposure...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28651175/challenges-in-gc-ms-analysis-case-studies-on-phenibut-and-ethylphenidate
#8
Hui Zhi Shirley Lee, Mei Ching Ong, Jong Lee Wendy Lim, Tiong Whei Angeline Yap
The challenges associated with drug analysis using GC-MS such as thermal degradation, cyclisation or unwanted side reactions causing potential erroneous identification have become evident in view of the high surge in new drugs available in the market. Two case studies illustrated how alternative methods or modifications to existing techniques can help to circumvent the limitations. In the first case study, phenibut which is a GABA analogue, cyclises to 4-phenyl-2-pyrrolidinone under thermal conditions. The identification of phenibut was achieved through derivatisation and identification of its TMS derivative...
June 9, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28651171/the-relevance-of-inter-and-intrastrain-differences-in-mice-and-rats-and-their-implications-for-models-of-seizures-and-epilepsy
#9
REVIEW
Wolfgang Löscher, Russell J Ferland, Thomas N Ferraro
It is becoming increasingly clear that the genetic background of mice and rats, even in inbred strains, can have a profound influence on measures of seizure susceptibility and epilepsy. These differences can be capitalized upon through genetic mapping studies to reveal genes important for seizures and epilepsy. However, strain background and particularly mixed genetic backgrounds of transgenic animals need careful consideration in both the selection of strains and in the interpretation of results and conclusions...
June 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28651128/local-up-regulation-of-interferon-%C3%AE-ifn-%C3%AE-following-disc-herniation-is-involved-in-the-inflammatory-response-underlying-acute-lumbar-radicular-pain
#10
Gunn-Helen Moen, Aurora Moen, Elina I Schistad, Johannes Gjerstad
Lumbar radicular pain after disc herniation may be associated with release of pro-inflammatory cytokines from nucleus pulposus (NP) tissue. In the present study we examined the role of interferon-γ (IFN-γ) and cluster of differentiation 68 (CD68) in the acute phase of this process. First, in an animal model mimicking the clinical situation after disc herniation, the role of IFN-γ close to the dorsal nerve roots was studied. Next, in patients with lumbar radicular pain due to disc herniation, we examined how two single nucleotide polymorphisms (SNPs; rs2069705 and rs2069718) are important for the IFN-γ expression influenced the pain behavior...
June 23, 2017: Cytokine
https://www.readbyqxmd.com/read/28651125/online-patient-information-on-vagus-nerve-stimulation-how-reliable-is-it-for-facilitating-shared-decision-making
#11
Ronak Ved, Naomi Cobbold, Kueni Igbagiri, Mark Willis, Paul Leach, Malik Zaben
PURPOSE: This study evaluates the quality of information available on the internet for carers of children with epilepsy considering treatment with Vagus Nerve Stimulation (VNS). METHODS: Selected key phrases were entered into two popular search engines (Google™, Yahoo™). These phrases were: "Vagus nerve stimulator", alone and in combination with "childhood epilepsy", "paediatric epilepsy" and "epilepsy in childhood"; "VNS", and "VNS epilepsy". The first 50 hits per search were then screened...
June 15, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28651107/how-seasonality-and-weather-affect-perinatal-health-comparing-the-experiences-of-indigenous-and-non-indigenous-mothers-in-kanungu-district-uganda
#12
Sarah MacVicar, Lea Berrang-Ford, Sherilee Harper, Vivienne Steele, Shuaib Lwasa, Didacus Namanya Bambaiha, Sabastien Twesigomwe, Grace Asaasira, Nancy Ross
Maternal and newborn health disparities and the health impacts of climate change present grand challenges for global health equity, and there remain knowledge gaps in our understanding of how these challenges intersect. This study examines the pathways through which mothers are affected by seasonal and meteorological factors in sub-Saharan Africa in general, and Kanungu District (Uganda), in particular. We conducted a community-based study consisting of focus group discussions with mothers and interviews with health care workers in Kanungu District...
June 19, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28651106/computer-based-speech-therapy-for-childhood-speech-sound-disorders
#13
REVIEW
Lisa Furlong, Shane Erickson, Meg E Morris
BACKGROUND: With the current worldwide workforce shortage of Speech-Language Pathologists, new and innovative ways of delivering therapy to children with speech sound disorders are needed. Computer-based speech therapy may be an effective and viable means of addressing service access issues for children with speech sound disorders. AIM: To evaluate the efficacy of computer-based speech therapy programs for children with speech sound disorders. METHOD: Studies reporting the efficacy of computer-based speech therapy programs were identified via a systematic, computerised database search...
June 15, 2017: Journal of Communication Disorders
https://www.readbyqxmd.com/read/28651100/methodological-challenges-in-qualitative-content-analysis-a-discussion-paper
#14
Ulla H Graneheim, Britt-Marie Lindgren, Berit Lundman
This discussion paper is aimed to map content analysis in the qualitative paradigm and explore common methodological challenges. We discuss phenomenological descriptions of manifest content and hermeneutical interpretations of latent content. We demonstrate inductive, deductive, and abductive approaches to qualitative content analysis, and elaborate on the level of abstraction and degree of interpretation used in constructing categories, descriptive themes, and themes of meaning. With increased abstraction and interpretation comes an increased challenge to demonstrate the credibility and authenticity of the analysis...
June 17, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28651096/predicting-actions-from-subtle-preparatory-movements
#15
Maryam Vaziri-Pashkam, Sarah Cormiea, Ken Nakayama
To study how people anticipate others' actions, we designed a competitive reaching task. Subjects faced each other separated by a Plexiglas screen and their finger movements in 3D space were recorded with sensors. The first subject (Attacker) was instructed to touch one of two horizontally arranged targets on the screen. The other subject (Blocker) touched the same target as quickly as possible. Average finger reaction times (fRTs) were fast, much faster than reactions to a dot moving on the screen in the same manner as the Attacker's finger...
June 23, 2017: Cognition
https://www.readbyqxmd.com/read/28651095/the-influence-of-performance-on-action-effect-integration-in-sense-of-agency
#16
Wen Wen, Atsushi Yamashita, Hajime Asama
Sense of agency refers to the subjective feeling of being able to control an outcome through one's own actions or will. Prior studies have shown that both sensory processing (e.g., comparisons between sensory feedbacks and predictions basing on one's motor intentions) and high-level cognitive/constructive processes (e.g., inferences based on one's performance or the consequences of one's actions) contribute to judgments of sense of agency. However, it remains unclear how these two types of processes interact, which is important for clarifying the mechanisms underlying sense of agency...
June 23, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28651074/chimeric-antigen-receptor-engineered-natural-killer-and-natural-killer-t-cells-for-cancer-immunotherapy
#17
REVIEW
Dominique Bollino, Tonya J Webb
Natural killer (NK) cells of the innate immune system and NK T (NKT) cells, which have roles in both the innate and adaptive responses, are unique lymphocyte subsets that have similarities in their functions and phenotypes. Both cell types can rapidly respond to the presence of tumor cells and participate in immune surveillance and antitumor immune responses. This has incited interest in the development of novel cancer therapeutics based on NK and NKT cell manipulation. Chimeric antigen receptors (CARs), generated through the fusion of an antigen-binding region of a monoclonal antibody or other ligand to intracellular signaling domains, can enhance lymphocyte targeting and activation toward diverse malignancies...
June 9, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28651065/the-removal-of-particle-reactive-radionuclides-in-shallow-water-bottom-scavenging-versus-particle-settling-of-iodine-131-and-beryllium-7
#18
Michael P Montenero, Elizabeth K Dilbone, James T Waples
In pelagic waters, the removal of particle-reactive radionuclides is controlled by nuclide sorption to particles and subsequent settling by gravity. However, in shallow nearshore waters, the dominant mechanism of nuclide scavenging is not so clear. Understanding how particle-reactive radionuclides are scavenged from the water column is critical if these tracers are to be used as proxies of particle flux in shallow aquatic systems. In this study, we present evidence that the removal of particle-reactive radionuclides in nearshore and turbulent waters is primarily controlled by bottom scavenging...
June 23, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28651057/how-to-identify-plasmons-from-the-optical-response-of-nanostructures
#19
Runmin Zhang, Luca Bursi, Joel D Cox, Yao Cui, Caroline M Krauter, Alessandro Alabastri, Alejandro Manjavacas, Arrigo Calzolari, Stefano Corni, Elisa Molinari, Emily A Carter, F Javier Garcia de Abajo, Hui Zhang, Peter Nordlander
A promising trend in plasmonics involves shrinking the size of plasmon-supporting structures down to a few nanometers, thus enabling control over light-matter interaction at extreme-subwavelength scales. In this limit, quantum-mechanical effects, such as nonlocal screening and size quantization, strongly affect the plasmonic response, rendering it substantially different from classical predictions. For very small clusters and molecules, collective plasmonic modes are hard to distinguish from other excitations such as single-electron transitions...
June 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28651052/inhomogeneity-in-ethylammonium-nitrate-acetonitrile-binary-mixtures-part-i-the-highest-low-q-excess-so-far-reported
#20
Alessandro Mariani, Ruggero Caminiti, Fabio Ramondo, Giovanna Salvitti, Francesca Mocci, Lorenzo Gontrani
The binary mixtures of the ionic liquid ethylammonium nitrate with acetonitrile have been studied by means of Wide and Small Angle X-ray Scattering and via two different computational methods, namely classical molecular dynamics and DFT. Our results show how the local arrangement is directly linked to the long-range structure. Moreover, we found once again a similarity in the physicochemical behaviour of ethylammonium nitrate and water.
June 26, 2017: Journal of Physical Chemistry Letters
keyword
keyword
112324
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"