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https://www.readbyqxmd.com/read/28089508/a-reply-to-douze-and-delagnes-s-the-pattern-of-emergence-of-a-middle-stone-age-tradition-at-gademotta-and-kulluletti-ethiopia-through-convergent-tool-and-point-technologies-j-hum-evol-91-2016-93-121
#1
Yonatan Sahle, David R Braun
Douze and Delagnes (2016) revisit Middle Stone Age (MSA) lithic assemblages from the Gademotta Formation (Fm.), Ethiopia. Their analysis of selected assemblages from three of the 1972 excavations expands the original typo-technological interpretations by Wendorf and Schild (1974). We particularly welcome their evaluation of our recent inferences about the function of pointed artifacts and technological patterns in the Gademotta Fm. (Sahle et al., 2013, 2014). However, we find several arguments and conclusions in Douze and Delagnes (2016) to be rather unconvincing and irreconcilable with results from analyses of whole assemblages (Wendorf and Schild, 1974; Sahle et al...
January 12, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28081237/co-occurrence-of-asthma-and-nephrolithiasis-in-children
#2
Ganesh K Kartha, Ina Li, Suzy Comhair, Serpil C Erzurum, Manoj Monga
It has been proposed that epithelial dysfunction and inflammation may predispose patients to kidney stone formation. Asthma is another chronic condition related to epithelial dysfunction and inflammation. We hypothesized that pediatric patients with asthma would have an increased prevalence of nephrolithiasis. Furthermore, we investigated if asthma patients with nephrolithiasis have clinical characteristics and urine profiles that point to mechanisms of stone formation. We evaluated 865 pediatric patients who had a diagnosis of nephrolithiasis...
2017: PloS One
https://www.readbyqxmd.com/read/28080987/ploidy-dynamics-and-evolvability-in-fungi
#3
REVIEW
Noa Blutraich Wertheimer, Neil Stone, Judith Berman
Rapid responses to acute stresses are essential for stress survival and are critical to the ability of fungal pathogens to adapt to new environments or hosts. The rapid emergence of drug resistance is used as a model for how fungi adapt and survive stress conditions that inhibit the growth of progenitor cells. Aneuploidy and loss of heterozygosity (LOH), which are large-scale genome shifts involving whole chromosomes or chromosome arms, occur at higher frequency than point mutations and have the potential to mediate stress survival...
December 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28075119/bubble-driven-detachment-of-bacteria-from-confined-microgeometries
#4
Sepideh Khodaparast, Minyoung Kevin Kim, Justin E Silpe, Howard A Stone
Moving air-liquid interfaces, for example, bubbles, play a significant role in the detachment and transport of colloids and microorganisms in confined systems as well as unsaturated porous media. Moreover, they can effectively prevent and/or postpone the development of mature biofilms on surfaces that are colonized by bacteria. Here we demonstrate the dynamics and quantify the effectiveness of this bubble-driven detachment process for the bacterial strain Staphylococcus aureus. We investigate the effects of interface velocity and geometrical factors through microfluidic experiments that mimic some of the confinement features of pore-scale geometries...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28068364/meta-analysis-of-stenting-versus-non-stenting-for-the-treatment-of-ureteral-stones
#5
Hai Wang, Libo Man, Guizhong Li, Guanglin Huang, Ning Liu, Jianwei Wang
BACKGROUND AND AIM: Ureteroscopic lithotripsy (URL) and extracorporeal shock wave lithotripsy (ESWL) are two widely used methods for the treatment of ureteral stones. The need for ureteral stenting during these procedures is controversial. In this meta-analysis, we evaluated the benefits and disadvantages of ureteral stents for the treatment of ureteral stones. METHODS: Databases including PubMed, Embase and Cochrane library were selected for systematic review of randomized controlled trials (RCTs) comparing outcomes with or without stenting during URL and ESWL...
2017: PloS One
https://www.readbyqxmd.com/read/28062298/ccl3-and-mmp-9-are-induced-by-tl1a-during-death-receptor-3-tnfrsf25-dependent-osteoclast-function-and-systemic-bone-loss
#6
Fraser L Collins, Jessica O Williams, Anja C Bloom, Ravinder K Singh, Lauren Jordan, Michael D Stone, Laura R McCabe, Eddie C Y Wang, Anwen S Williams
Reduced bone density and secondary osteoporosis, resulting in increased risk of fracture, is a significant complicating factor in the inflammatory arthritides. While the exact etiology of systemic bone loss is not fully elucidated, recent insights into the tumor necrosis factor super family (TNFSF) revealed a potential role for death receptor 3 (DR3/TNFRSF25) and one of its ligands, TNF-like protein 1A (TL1A/TNFSF15). The mechanisms by which DR3/TL1A signalling modulates bone loss are unclear. We investigated the effect of DR3/TL1A signalling upon osteoclast-dependent chemokine and MMP production to unravel novel mechanisms whereby this pathway regulates OC formation and OC-dependent bone resorption...
January 4, 2017: Bone
https://www.readbyqxmd.com/read/28060885/antibodies-targeting-closely-adjacent-or-minimally-overlapping-epitopes-can-displace-one-another
#7
Yasmina Noubia Abdiche, Andy Yik Yeung, Irene Ni, Donna Stone, Adam Miles, Winse Morishige, Andrea Rossi, Pavel Strop
Here we describe how real-time label-free biosensors can be used to identify antibodies that compete for closely adjacent or minimally overlapping epitopes on their specific antigen via a mechanism of antibody displacement. By kinetically perturbing one another's binding towards their antigen via the formation of a transient trimolecular complex, antibodies can displace one another in a fully reversible and dose-dependent manner. Displacements can be readily identified when epitope binning assays are performed in a classical sandwich assay format whereby a solution antibody (analyte) is tested for binding to its antigen that is first captured via an immobilized antibody (ligand) because an inverted sandwiching response is observed when an analyte displaces a ligand, signifying the antigen's unusually rapid dissociation from its ligand...
2017: PloS One
https://www.readbyqxmd.com/read/28058642/synthesis-and-electrospraying-of-nanoscale-mof-metal-organic-framework-for-high-performance-co2-adsorption-membrane
#8
Wahiduzzaman, Kelsey Allmond, John Stone, Spencer Harp, Khan Mujibur
We report the sonochemical synthesis of MOF (metal organic framework) nanoparticles of 30-200 nm in size and electrospraying of those particles on electrospun nanofibers to process a MOF-attached nanofibrous membrane. This membrane displayed significant selectivity towards CO2 and capacity of adsorbing with 4000-5000 ppm difference from a mixed gas flow of 1% CO2 and 99% N2. Applying ultrasonic waves during the MOF synthesis offered rapid dispersion and formation of crystalline MOF nanoparticles in room temperature...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28058006/paraurethral-cyst-with-multiple-stones-a-rare-case-report
#9
Gaurav Prakash, Shreya Karan, Satya Narayan Sankhwar, Sangeeta Karan
Paraurethral cyst is a benign cystic disorder of anterior vaginal wall. Many secondary complications have been described in literature, but stone formation in the cyst is a rare phenomenon. We are reporting a case of a 35-year-old multiparous woman who presented with lower urinary tract symptoms, dysuria, and dyspareunia. She was diagnosed as a case of the paraurethral cyst with stones and was managed successfully. Various differential diagnoses have been suggested, most important being urethral diverticulum, ruled out by urethroscopy...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28057994/a-completely-calcified-prostate
#10
Vinod Priyadarshi, Nidhi Sehgal
Prostatic calcification and prostatic calculus formation is commonly seen in adult population with chronic prostatitis, however, gross prostatic calcification which involves more than 3 cm(2) of the gland is quite rare. We are presenting here one such case in which almost whole glandular prostate was converted into stone which is never reported so far.
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28056531/sialendoscopy-for-sublingual-gland-sialolithiasis
#11
Lindsay Goodstein, Lauren Galinat, Joseph Curry, Adam Luginbuhl, David Cognetti
OBJECTIVES: To present a unique series of sublingual gland sialolithiasis treated with sialendoscopy. METHODS: A retrospective chart review of patients at a single tertiary care academic center undergoing sialendoscopy. RESULTS: We present a series of 4 patients who presented with 1 episode each of sialadenitis without preceding postprandial symptoms. In each case, sialendoscopy identified the calculi embedded within the sublingual duct of Bartholin at its emptying point into Wharton's duct...
December 1, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28054104/inhalation-of-gas-metal-arc-stainless-steel-welding-fume-promotes-lung-tumorigenesis-in-a-j-mice
#12
Lauryn M Falcone, Aaron Erdely, Terence G Meighan, Lori A Battelli, Rebecca Salmen, Walter McKinney, Samuel Stone, Amy Cumpston, Jared Cumpston, Ronnee N Andrews, Michael Kashon, James M Antonini, Patti C Zeidler-Erdely
Epidemiologic studies suggest an increased risk of lung cancer with exposure to welding fumes, but controlled animal studies are needed to support this association. Oropharyngeal aspiration of collected "aged" gas metal arc-stainless steel (GMA-SS) welding fume has been shown by our laboratory to promote lung tumor formation in vivo using a two-stage initiation-promotion model. Our objective in this study was to determine whether inhalation of freshly generated GMA-SS welding fume also acts as a lung tumor promoter in lung tumor-susceptible mice...
January 4, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28049497/two-differentially-structured-collagen-scaffolds-for-potential-urinary-bladder-augmentation-proof-of-concept-study-in-a-g%C3%A3-ttingen-minipig-model
#13
Dorothea Leonhäuser, Katja Stollenwerk, Volker Seifarth, Isabella M Zraik, Michael Vogt, Pramod K Srinivasan, Rene H Tolba, Joachim O Grosse
BACKGROUND: The repair of urinary bladder tissue is a necessity for tissue loss due to cancer, trauma, or congenital abnormalities. Use of intestinal tissue is still the gold standard in the urological clinic, which leads to new problems and dysfunctions like mucus production, stone formation, and finally malignancies. Therefore, the use of artificial, biologically derived materials is a promising step towards the augmentation of this specialised tissue. The aim of this study was to investigate potential bladder wall repair by two collagen scaffold prototypes, OptiMaix 2D and 3D, naïve and seeded with autologous vesical cells, as potential bladder wall substitute material in a large animal model...
January 4, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28046010/tetr-family-regulator-brpt-modulates-biofilm-formation-in-streptococcus-sanguinis
#14
Jinlin Liu, Victoria N Stone, Xiuchun Ge, Madison Tang, Fadi Elrami, Ping Xu
Biofilms are a key component in bacterial communities providing protection and contributing to infectious diseases. However, mechanisms involved in S. sanguinis biofilm formation have not been clearly elucidated. Here, we report the identification of a novel S. sanguinis TetR repressor, brpT (Biofilm Regulatory Protein TetR), involved in biofilm formation. Deletion of brpT resulted in a significant increase in biofilm formation. Interestingly, the mutant accumulated more water soluble and water insoluble glucans in its biofilm compared to the wild-type and the complemented mutant...
2017: PloS One
https://www.readbyqxmd.com/read/28017513/from-catheter-to-kidney-stone-the-uropathogenic-lifestyle-of-proteus-mirabilis
#15
REVIEW
Allison N Norsworthy, Melanie M Pearson
Proteus mirabilis is a model organism for urease-producing uropathogens. These diverse bacteria cause infection stones in the urinary tract and form crystalline biofilms on indwelling urinary catheters, frequently leading to polymicrobial infection. Recent work has elucidated how P. mirabilis causes all of these disease states. Particularly exciting is the discovery that this bacterium forms large clusters in the bladder lumen that are sites for stone formation. These clusters, and other steps of infection, require two virulence factors in particular: urease and MR/P fimbriae...
December 22, 2016: Trends in Microbiology
https://www.readbyqxmd.com/read/28012336/forgotten-cbd-stent-102-months-with-stone-stent-complex-a-case-report
#16
Varsha Barai, Jagadish Hedawoo, Sanjay Changole
INTRODUCTION: Choledocholithiasis is presence of stone in Common bile duct (CBD) which can be treated by endoscopy or surgery [1]. Retained foreign bodies like stents forms a nidus for stone formation resulting in pain, fever, jaundice. CASE PRESENTATION: 60 years female patient admitted in surgery ward with features of cholangitis with computed tomography showing cholangitic abscess with dilated common bile duct and sludge around stent in situ. Stone was found at proximal end of stent during surgery...
December 7, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28011229/differential-colony-size-cell-length-and-cellular-proteome-of-escherichia-coli-isolated-from-urine-vs-stone-nidus-of-kidney-stone-patients
#17
Ratree Tavichakorntrakool, Patcharee Boonsiri, Vitoon Prasongwatana, Aroonlug Lulitanond, Chaisiri Wongkham, Visith Thongboonkerd
BACKGROUND: Escherichia coli is associated with kidney stone disease, as a cause or an effect (secondary or recurrent urinary tract infection, UTI). Defining phenotypic or functional differences between E. coli inside stone nidus (ECS, associated with infection-induced stone) and outside the stone (i.e. from urine) (ECU, represented secondary infection) would be helpful to better understand bacterial involvement in this disease. METHODS: ECS and ECU were isolated from 100 stone formers and subjected to antimicrobial susceptibility test, ERIC-PCR genotyping, determination of biofilm formation, bacterial colony size on agar plate and cell length in broth, 2-DE, nanoLC-MS/MS, protein network analysis, and pyruvate dehydrogenase (PDH) activity assay...
December 20, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28010876/central-ghrelin-resistance-permits-the-overconsolidation-of-fear-memory
#18
Elia S Harmatz, Lauren Stone, Seh Hong Lim, Graham Lee, Anna McGrath, Barbara Gisabella, Xiaoyu Peng, Eliza Kosoy, Junmei Yao, Elizabeth Liu, Nuno J Machado, Veronica S Weiner, Warren Slocum, Rodrigo A Cunha, Ki A Goosens
BACKGROUND: There are many contradictory findings about the role of the hormone ghrelin in aversive processing, with studies suggesting that ghrelin signaling can both inhibit and enhance aversion. Here, we characterize and reconcile the paradoxical role of ghrelin in the acquisition of fearful memories. METHODS: We used enzyme-linked immunosorbent assay to measure endogenous acyl-ghrelin and corticosterone at time points surrounding auditory fear learning. We used pharmacological (systemic and intra-amygdala) manipulations of ghrelin signaling and examined several aversive and appetitive behaviors...
November 29, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28003445/distance-decay-effect-in-stone-tool-transport-by-wild-chimpanzees
#19
Lydia V Luncz, Tomos Proffitt, Lars Kulik, Michael Haslam, Roman M Wittig
Stone tool transport leaves long-lasting behavioural evidence in the landscape. However, it remains unknown how large-scale patterns of stone distribution emerge through undirected, short-term transport behaviours. One of the longest studied groups of stone-tool-using primates are the chimpanzees of the Taï National Park in Ivory Coast, West Africa. Using hammerstones left behind at chimpanzee Panda nut-cracking sites, we tested for a distance-decay effect, in which the weight of material decreases with increasing distance from raw material sources...
December 28, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28002741/shape-transformations-of-lipid-bilayers-following-rapid-cholesterol-uptake
#20
Mohammad Rahimi, David Regan, Marino Arroyo, Anand Bala Subramaniam, Howard A Stone, Margarita Staykova
High cholesterol levels in the blood increase the risk of atherosclerosis. A common explanation is that the cholesterol increase in the plasma membrane perturbs the shape and functions of cells by disrupting the cell signaling pathways and the formation of membrane rafts. In this work, we show that after enhanced transient uptake of cholesterol, mono-component lipid bilayers change their shape similarly to cell membranes in vivo. The bilayers either expel lipid protrusions or spread laterally as a result of the ensuing changes in their lipid density, the mechanical constraints imposed on them, and the properties of cyclodextrin used as a cholesterol donor...
December 20, 2016: Biophysical Journal
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