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https://www.readbyqxmd.com/read/28530651/surface-attached-molecules-control-staphylococcus-aureus-quorum-sensing-and-biofilm-development
#1
Minyoung Kevin Kim, Aishan Zhao, Ashley Wang, Zachary Z Brown, Tom W Muir, Howard A Stone, Bonnie L Bassler
Bacteria use a process called quorum sensing to communicate and orchestrate collective behaviours, including virulence factor secretion and biofilm formation. Quorum sensing relies on the production, release, accumulation and population-wide detection of signal molecules called autoinducers. Here, we develop concepts to coat surfaces with quorum-sensing-manipulation molecules as a method to control collective behaviours. We probe this strategy using Staphylococcus aureus. Pro- and anti-quorum-sensing molecules can be covalently attached to surfaces using click chemistry, where they retain their abilities to influence bacterial behaviours...
May 22, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28526618/24-hour-urine-metabolic-differences-between-solitary-and-multiple-stone-formers-results-of-the-collaboration-on-urolithiasis-in-pediatrics-cup-working-group
#2
Theodore R Saitz, Solange Mongoue-Tchokote, Cynthia Sharadin, Dana W Giel, Sean Corbett, Larisa Kovacevic, Aaron P Bayne
INTRODUCTION: Specific factors associated with the risk of developing pediatric urinary stone disease remain unclear, especially those that may be associated with recurrent stone disease. OBJECTIVE: We compared the results of 24-h urine collections in children with a solitary stone episode to those with multiple stone episodes to determine if there is a difference that may be associated with multiple stone formation in children. STUDY DESIGN: A multi-institutional retrospective analysis was completed to assess 24-h urinary metabolic profiles in children with urolithiasis aged 2-18 years old...
April 20, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28507586/neutrophil-elastase-stimulates-muc5ac-expression-in-human-biliary-epithelial-cells-a-possible-pathway-of-pkc-nox-ros
#3
Yu Tian, Min Li, Shuodong Wu, Duoliang Wang, Ben Sun, Junqing Xie, Hong Wang
INTRODUCTION: Bacterial infection and bile flow retardation form a vicious cycle which promotes stone formation and recurrence, and it seems that mucin overexpression plays an important role in this process. However, the mechanism of increased mucus secretion in the biliary tract by bacterial infection and its treatment remain unclear. MATERIAL AND METHODS: Human biliary epithelial cells were induced by neutrophil elastase (NE), and H2O2 production in the cell supernatants was detected by a specific kit, and then cells were pretreated with a H2O2 inhibitor, and expression of MUC5AC was detected by real-time polymerase chain reaction (PCR), Western blot, and immunohistochemistry...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28505339/labrs-a-rosetta-stone-for-retrospective-standardization-of-clinical-laboratory-test-results
#4
Ronald George Hauser, Douglas B Quine, Alex Ryder
Objective: Clinical laboratories in the United States do not have an explicit result standard to report the 7 billion laboratory tests results they produce each year. The absence of standardized test results creates inefficiencies and ambiguities for secondary data users. We developed and tested a tool to standardize the results of laboratory tests in a large, multicenter clinical data warehouse. Methods: Laboratory records, each of which consisted of a laboratory result and a test identifier, from 27 diverse facilities were captured from 2000 through 2015...
May 12, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28498001/abce1-a-special-factor-that-orchestrates-translation-at-the-crossroad-between-recycling-and-initiation
#5
Eder Mancera-Martínez, Jailson Brito Querido, Leos Shivaya Valasek, Angelita Simonetti, Yaser Hashem
For many years initiation and termination of mRNA translation have been studied separately. However, a direct link between these two isolated stages has been suggested by the fact that some initiation factors also control termination and can even promote ribosome recycling; i.e. the last stage where post-terminating 80 S ribosomes are split to start a new round of initiation. Notably, it is now firmly established that, among other factors, ribosomal recycling critically requires the NTPase ABCE1. However, several earlier reports have proposed that ABCE1 also somehow participates in the initiation complex assembly...
May 12, 2017: RNA Biology
https://www.readbyqxmd.com/read/28497043/the-effect-of-different-pollination-on-the-expression-of-dangshan-su-pear-microrna
#6
Xi Cheng, Chongchong Yan, Jinyun Zhang, Chenhui Ma, Shumei Li, Qing Jin, Nan Zhang, Yunpeng Cao, Yi Lin, Yongping Cai
The high-throughput sequencing of pear "Dangshan Su" × "Yali" (whose fruits lignin and stone cell content are high and quality is poor) and pear "Dangshan Su" × "Wonhwang" (whose fruits with low content of lignin and stone cell and the quality are better ) found that the expressions of these two miRNAs (pyr-1809 and pyr-novel-miR-144-3p) were significantly different; their corresponding target genes encode two kinds of laccase (Pbr018935.1 and Pbr003857.1). qRT-PCR results showed that these two enzymes are involved in the formation of lignin and stone cells and the existence of these two miRNAs has a negative effect on them...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28496123/systematic-evaluation-for-effects-of-urine-ph-on-calcium-oxalate-crystallization-crystal-cell-adhesion-and-internalization-into-renal-tubular-cells
#7
Juthatip Manissorn, Kedsarin Fong-Ngern, Paleerath Peerapen, Visith Thongboonkerd
Urine pH has been thought to be an important factor that can modulate kidney stone formation. Nevertheless, there was no systematic evaluation of such pH effect. Our present study thus addressed effects of differential urine pH (4.0-8.0) on calcium oxalate (CaOx) crystallization, crystal-cell adhesion, crystal internalization into renal tubular cells, and binding of apical membrane proteins to the crystals. Microscopic examination revealed that CaOx monohydrate (COM), the pathogenic form, was crystallized with greatest size, number and total mass at pH 4...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28491855/nephrolithiasis-in-elderly-population-effect-of-demographic-characteristics
#8
Emadoddin Moudi, Seyed Reza Hosseini, Ali Bijani
BACKGROUND: Kidney stone (nephrolithiasis) is one of the most common diseases. During the past several decades, its prevalence and incidence have increased markedly in elderly population. OBJECTIVES: This study was conducted to evaluate the risk factors for nephrolithiasis in elderly population. PATIENTS AND METHODS: This study was based on the Amirkola Health and Ageing Project (AHAP). Elderly people with kidney stones in every size, type and number were considered to be the case group and other subjects without a history of kidney stones served as control group...
March 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28480748/effect-of-fruit-extract-on-renal-stone-formation-and-kidney-injury-in-rats
#9
Nasrin Partovi, Mohammad Reza Ebadzadeh, S Jamilaldin Fatemi, Mohammad Khaksari
This study investigated the effect of oral administration of Cactus fruit extracts on calcium oxalate deposition, malondialdehyde (MDA) and superoxide dismutase (SOD) activity in rat model. About 42 rats were used for the study. The animals were divided into seven groups. Control group maintained on regular rat food and drinking water throughout the study period, whereas in other groups nephrolithiasis was induced by ethylene glycol. Rats in kidney stone group were sacrificed after 28 days and all remaining groups after 58 days...
May 7, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28478823/nanoparticles-as-agents-targeting-cholesterol-crystallization-in-atherosclerosis
#10
Yana Anfinogenova, Maria Shvedova, Sergey V Popov
This article introduces a hypothesis on nanoparticle-mediated modulation of cholesterol crystal behaviour in the atherosclerotic plaques. The role of cholesterol crystals in progression of atherosclerosis is emphasized. Proposed mechanism of spontaneous cholesterol crystal formation in the organism is discussed. Mechanisms and factors associated with the nanoparticle-mediated modulation of cholesterol crystal behaviour are proposed. Authors hypothesize that specially designed nanoparticles may therapeutically modulate cholesterol crystal behaviour in atherosclerosis...
May 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28469633/fine-root-abundance-and-dynamics-of-stone-pine-pinus-cembra-at-the-alpine-treeline-is-not-impaired-by-self-shading
#11
Petra Kubisch, Christoph Leuschner, Heinz Coners, Andreas Gruber, Dietrich Hertel
Low temperatures are crucial for the formation of the alpine treeline worldwide. Since soil temperature in the shade of tree canopies is lower than in open sites, it was assumed that self-shading may impair the trees' root growth performance. While experiments with tree saplings demonstrate root growth impairment at soil temperatures below 5-7°C, field studies exploring the soil temperature - root growth relationship at the treeline are missing. We recorded soil temperature and fine root abundance and dynamics in shaded and sun-exposed areas under canopies of isolated Pinus cembra trees at the alpine treeline...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28469307/silicate-urolithiasis-in-a-paediatric-patient
#12
Rajarajan Pichandi, Sathish Kumar Motilal Raamya
Silicate urolithiasis is rare in humans (0.2%) but common in herbivorous animals. We report a previously unreported instance in India where a pediatric patient with renal pelvic calculus who underwent percutaneous nephrolithotomy was found to have silicate urolithiasis on stone analysis. Retrospective analysis did not reveal any risk factors associated with silicate stone formation.
April 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28467511/urinary-metals-in-a-spontaneous-canine-model-of-calcium-oxalate-urolithiasis
#13
Eva Furrow, Molly E McCue, Jody P Lulich
Calcium oxalate urolithiasis is a common and painful condition in people. The pathogenesis of this disease is complex and poorly understood. Laboratory animal and in vitro studies have demonstrated an effect of multiple trace metals in the crystallization process, and studies in humans have reported relationships between urinary metal concentrations and stone risk. Dogs are a spontaneous model of calcium oxalate urolithiasis, and the metal content of canine calcium oxalate stones mirrors that of human stones...
2017: PloS One
https://www.readbyqxmd.com/read/28464662/shock-formation-and-nonlinear-saturation-effects-in-the-ultrasound-field-of-a-diagnostic-curvilinear-probe
#14
Maria M Karzova, Petr V Yuldashev, Oleg A Sapozhnikov, Vera A Khokhlova, Bryan W Cunitz, Wayne Kreider, Michael R Bailey
Newer imaging and therapeutic ultrasound technologies may benefit from in situ pressure levels higher than conventional diagnostic ultrasound. One example is the recently developed use of ultrasonic radiation force to move kidney stones and residual fragments out of the urinary collecting system. A commercial diagnostic 2.3 MHz C5-2 array probe has been used to deliver the acoustic pushing pulses. The probe is a curvilinear array comprising 128 elements equally spaced along a convex cylindrical surface. The effectiveness of the treatment can be increased by using higher transducer output to provide a stronger pushing force; however nonlinear acoustic saturation can be a limiting factor...
April 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28460932/nature-of-protein-protein-interactions-during-the-gelation-of-canola-protein-isolate-networks
#15
Jae He Kim, Natallia V Varankovich, Andrea K Stone, Michael T Nickerson
The nature of interactions involved during the gelation of a canola protein isolate was investigated using rheology and fractal imaging at neutral pH as a function of protein concentration (5.0-9.0% w/w). The onset of denaturation and the denaturation temperature by differential scanning calorimetry for canola protein isolate (CPI; 98.2% protein) was 78.6°C and 87.1°C, respectively. Rheological testing determined the gelation temperature (Tgel) to be ~87-90°C for all concentrations. The log % strain at break increased from 1...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28460910/organic-acids-in-kakadu-plum-terminalia-ferdinandiana-the-good-ellagic-the-bad-oxalic-and-the-uncertain-ascorbic
#16
David J Williams, David Edwards, Sharon Pun, Mridusmita Chaliha, Brian Burren, Ujang Tinggi, Yasmina Sultanbawa
The phenolic ellagic acid (EA) is receiving increasing attention for its nutritional and pharmacological potential as an antioxidant and antimicrobial agent. The Australian native Kakadu plum (Terminalia ferdinandiana) fruit is an abundant source of this phytochemical. The fruit also contains large amounts of vitamin C (mainly as ascorbic acid, AA) and possibly the undesirable oxalic acid (OA). Regular consumption of high oxalate foods poses a variety of health risks in humans including interference with calcium absorption and kidney stone formation...
November 2016: Food Research International
https://www.readbyqxmd.com/read/28458858/para-spinal-abscess-following-gallstones-spillage-during-laparoscopic-cholecystectomy-an-unusual-presentation
#17
A Canna, F Adaba, E Sezen, A Bissett, G J Finch, U Ihedioha
Gallbladder perforation with subsequent gallstone spillage can occur with higher frequency in laparoscopic cholecystectomy than in traditional open approach. Gallstone abscess formation from stone spillage post-cholecystectomy is extremely rare. We present a case of para-spinal abscess formation 5 years after spilled gallstones following laparoscopic cholecystectomy.
March 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28457217/the-role-of-fetuin-a-and-electrolytes-in-the-etiology-of-sialolithiasis
#18
Hasan Demirhan, Muhammet Yıldız, Özlem Önerci Çelebi, Şehide Baz, Berrin Berçik İnal, Özgür Yiğit
Objective The aim of this study was to investigate serum and saliva fetuin-A, protein, and electrolyte levels in patients with sialolithiasis. Study Design Prospective randomized controlled study. Setting Tertiary center. Subjects and Methods Twenty patients with recurrent sialadenitis secondary to submandibular salivary gland stones and 20 asymptomatic healthy volunteers without salivary gland stones were included in the study. Bimanual palpation and ultrasonography were performed in the patient and control groups...
May 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28448530/response-of-npt2a-knockout-mice-to-dietary-calcium-and-phosphorus
#19
Yuwen Li, Daniel Caballero, Julian Ponsetto, Alyssa Chen, Chuanlong Zhu, Jun Guo, Marie Demay, Harald Jüppner, Clemens Bergwitz
Mutations in the renal sodium-dependent phosphate co-transporters NPT2a and NPT2c have been reported in patients with renal stone disease and nephrocalcinosis, but the relative contribution of genotype, dietary calcium and phosphate to the formation of renal mineral deposits is unclear. We previously reported that renal calcium phosphate deposits persist and/or reappear in older Npt2a-/- mice supplemented with phosphate despite resolution of hypercalciuria while no deposits are seen in wild-type (WT) mice on the same diet...
2017: PloS One
https://www.readbyqxmd.com/read/28446830/bryophyllum-pinnatum-leaf-extracts-prevent-formation-of-renal-calculi-in-lithiatic-rats
#20
Mahendra Yadav, Vijay D Gulkari, Manish M Wanjari
BACKGROUND: Bryophyllum pinnatum, commonly known as Pattharcaṭṭa, is used traditionally in ethnomedicinal practices for the treatment of kidney stone and urinary insufficiency. AIM: The present study evaluated the effect of Bryophyllum pinnatum on ethylene glycol (EG)-induced renal calculi in rats. MATERIALS AND METHODS: Renal calculi were induced in rats by administration of 0.75% EG in drinking water and co-treated orally with standard drug, Cystone (750 mg/kg), or alcoholic and hydro-alcoholic extracts in doses of 100, 200 and 400 mg/kg for 28 days...
October 2016: Ancient Science of Life
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