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https://www.readbyqxmd.com/read/28208000/two-cases-of-plug-or-stone-in-remnant-intrapancreatic-choledochal-cysts-treated-with-endoscopic-retrograde-cholangiopancreatography
#1
Eunbee Kim, Min Ho Kang, Jisun Lee, Hanlim Choi, Jae-Woon Choi, Joung-Ho Han, Seon Mee Park
Incomplete resection of choledochal cysts (CCs) that extend deep into the pancreas can lead to protein plug or stone formation, pancreatitis, and cholangiocarcinoma. We encountered two cases of choledocholithiasis in remnant intrapancreatic CCs (IPCCs), in which the patients exhibited symptoms after 3 and 21 years of cyst excision. A 21-year-old woman who had undergone excision of a CC, as a neonate, presented with epigastric pain. Abdominal computed tomography (CT) revealed stones inside the remnant pancreatic cyst, which were removed by endoscopic retrograde cholangiopancreatography (ERCP), and her symptoms improved...
February 16, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28202101/berber-genealogy-and-the-politics-of-prehistoric-archaeology-and-craniology-in-french-algeria-1860s-1880s
#2
Bonnie Effros
Following the conquest of Algiers and its surrounding territory by the French army in 1830, officers noted an abundance of standing stones in this region of North Africa. Although they attracted considerably less attention among their cohort than more familiar Roman monuments such as triumphal arches and bridges, these prehistoric remains were similar to formations found in Brittany and other parts of France. The first effort to document these remains occurred in 1863, when Laurent-Charles Féraud, a French army interpreter, recorded thousands of dolmens and stone formations south-west of Constantine...
February 16, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28196538/functional-studies-of-drosophila-zinc-transporters-reveal-the-mechanism-for-zinc-excretion-in-malpighian-tubules
#3
Sai Yin, Qiuhong Qin, Bing Zhou
BACKGROUND: Zinc is an essential metal involved in many physiological processes. Previous work has identified a set of zinc transporters involved in Drosophila dietary zinc absorption. However, zinc excretion and reabsorption, the other two important processes to maintain zinc homeostasis, are not as well understood. In this work, we screened all the potential zinc transporter Zip (SLC39) and ZnT (SLC30) members for their likely roles in zinc excretion in Malpighian tubules, an insect organ functionally analogous to mammalian kidneys...
February 14, 2017: BMC Biology
https://www.readbyqxmd.com/read/28188435/marked-increase-in-urinary-excretion-of-apolipoproteins-in-children-with-nephrolithiasis-associated-with-hypercalciuria
#4
Larisa Kovacevic, Hong Lu, Joseph A Caruso, Tuhina Govil-Dalela, Ronald Thomas, Yegappan Lakshmanan
BACKGROUND: Using a proteomic approach, we aimed to identify and compare the urinary excretion of proteins involved in lipid transport and metabolism in children with kidney stones and hypercalciuria (CAL), hypocitraturia (CIT), and normal metabolic work-up (NM), and in healthy controls (HCs). Additionally, we aimed to confirm these results using ELISA, and to examine the relationship between the urinary excretion of selected proteins with demographic, dietary, blood, and urinary parameters...
February 10, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28185760/why-we-need-a-higher-suspicion-index-of-urolithiasis-in-children
#5
REVIEW
Pierluigi Marzuillo, Stefano Guarino, Andrea Apicella, Angela La Manna, Cesare Polito
BACKGROUND: Most children with symptoms of urolithiasis and urinary solute excretion abnormalities leading to stone formation have no calculi revealed by ultrasound or X-ray plain film ("occult urolithiasis"). This covers a large group of children presenting with common symptoms such as abdominal pain, hematuria, and dysuria, often faced by general practitioners and pediatricians. However, half or more of children with urolithiasis could present with abdominal/flank pain without specific urinary symptoms...
January 29, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28185107/protective-impact-of-resveratrol-in-experimental-rat-model-of-hyperoxaluria
#6
Taylan Oksay, Sedat Yunusoğlu, Mustafa Calapoğlu, I Aydın Candan, İbrahim Onaran, Osman Ergün, Alper Özorak
PURPOSE: Resveratrol (RES) is a polyphenol with antioxidant, anti-inflammatory, and many other physiological effects on tissues. In the present study, the effect of resveratrol in hyperoxaluria driven nephrolithiasis/nephrocalcinosis is investigated. METHODS: Wistar-Albino rats of 250-300 g (male, n = 24) were included in the present study. The rats were randomized into three groups: Group 1 consisted of the controls (n = 8), Group 2 of hyperoxaluria (1% ethylene glycol (EG), n = 8), and Group 3 of the treatment (1% EG + 10 mg/kg of RES, n = 8) group...
February 9, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28169459/long-term-effectiveness-and-complication-rates-of-bladder-augmentation-in-patients-with-neurogenic-bladder-dysfunction-a-systematic-review
#7
Lisette 't Hoen, Hazel Ecclestone, Bertil F M Blok, Gilles Karsenty, Véronique Phé, Romain Bossier, Jan Groen, David Castro-Diaz, Bárbara Padilla Fernández, Giulio Del Popolo, Stefania Musco, Jürgen Pannek, Thomas M Kessler, Tobias Gross, Marc P Schneider, Rizwan Hamid
AIMS: To systematically evaluate effectiveness and safety of bladder augmentation for adult neuro-urological patients. METHODS: The Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement was followed for review of publications. The Medline, Embase, and Cochrane controlled trial databases and clinicaltrial.gov were searched until January 2015. No limitations were placed on date or language. Non-original articles, conference abstracts, and publications involving children and animals were excluded...
February 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28166905/the-earliest-long-distance-obsidian-transport-evidence-from-the-%C3%A2-200%C3%A2-ka-middle-stone-age-sibilo-school-road-site-baringo-kenya
#8
Nick Blegen
This study presents the earliest evidence of long-distance obsidian transport at the ∼200 ka Sibilo School Road Site (SSRS), an early Middle Stone Age site in the Kapthurin Formation, Kenya. The later Middle Pleistocene of East Africa (130-400 ka) spans significant and interrelated behavioral and biological changes in human evolution including the first appearance of Homo sapiens. Despite the importance of the later Middle Pleistocene, there are relatively few archaeological sites in well-dated contexts (n < 10) that document hominin behavior from this time period...
February 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28165480/%C3%AE-lipoic-acid-treatment-prevents-cystine-urolithiasis-in-a-mouse-model-of-cystinuria
#9
Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N O'Leary, Arvind Ramanathan, Roy R Gerona, David W Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L Stoller, Pankaj Kapahi
Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria...
February 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28164160/pseudomonas-aeruginosa-as-an-etiologic-agent-of-nephrolithiasis-in-deep-water-divers
#10
Victoria Y Bird, Ryan Chastain-Gross, Raymond Sutkowski, Vincent G Bird, Paulas Vyas, Ryan Joseph
Background: A number of occupations and professions may be associated with unique hazards relevant to urologic care. Case Presentation: We relate the presentation, care, and the occupational hazard of urinary tract infection (UTI), presenting as cystitis and pyelonephritis, with stone formation in a scuba diver. The patient voiced concern that his diving suit malfunction was related to his UTI and stone disease. We review the risk of UTI in the diving environment. We also report the development of infection-related stone in this case...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/28152268/the-impact-of-gallium-content-on-degradation-bioactivity-and-antibacterial-potency-of-zinc-borate-bioactive-glass
#11
Alireza Rahimnejad Yazdi, Lawrence Torkan, Wendy Stone, Mark R Towler
Zinc borate glasses with increasing gallium content (0, 2.5, 5, 10, and 15 Wt % Ga) were synthesized and their degradation, bioactivity in simulated body fluid (SBF), and antibacterial properties were investigated. ICP measurements showed that increased gallium content in the glass resulted in increased gallium ion release and decreased release of other ions. Degradability declined with the addition of gallium, indicating the formation of more symmetric BO3 units with three bridging oxygens and asymmetric BO3 units with two bridging oxygens in the glass network as the gallium content in the series increased...
February 2, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28145045/intraluminal-bioresorbable-vascular-scaffold-dismantling-with-aneurysm-formation-leading-to-very-late-thrombosis
#12
Amisha Patel, Tamim Nazif, Gregg W Stone, Ziad A Ali
Coronary artery aneurysm formation has been described in patients after the placement of first-generation drug-eluting stents (DES), but is less common with newer generation metallic stents. In contrast, coronary artery aneurysm formation may be more common with the use of bioresorbable vascular scaffolds (BVS) due to the frequent formation of evaginations in the arterial wall seen with BVS. In this article, we describe a unique case of BVS dismantling and thrombus formation leading to an acute coronary syndrome thirty-two months after initial BVS placement...
February 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28138218/evaluation-of-a-2-aminoimidazole-variant-as-adjuvant-treatment-for-dermal-bacterial-infections
#13
G Logan Draughn, C Leigh Allen, Patricia A Routh, Maria R Stone, Kelly R Kirker, Laura Boegli, Ryan M Schuchman, Keith E Linder, Ronald E Baynes, Garth James, Christian Melander, Angela Pollard, John Cavanagh
2-Aminoimidazole (2-AI)-based compounds have been shown to efficiently disrupt biofilm formation, disperse existing biofilms, and resensitize numerous multidrug-resistant bacteria to antibiotics. Using Pseudomonas aeruginosa and Staphylococcus aureus, we provide initial pharmacological studies regarding the application of a 2-AI as a topical adjuvant for persistent dermal infections. In vitro assays indicated that the 2-AI H10 is nonbactericidal, resensitizes bacteria to antibiotics, does not harm the integument, and promotes wound healing...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28130022/improving-over-the-counter-medication-safety-for-older-adults-a-study-protocol-for-a-demonstration-and-dissemination-study
#14
Michelle A Chui, Jamie A Stone, Richard J Holden
BACKGROUND: Adverse drug events (ADEs) associated with over-the-counter (OTC) medications cause 178,000 hospitalizations each year. Older adults, aged 65 and older, are particularly vulnerable to ADEs. Of the 2.2 million older adults considered at risk for a major ADE, more than 50% are at risk due to concurrent use of an OTC and prescription medication. OBJECTIVES: To refine the intervention and implementation strategy through diagnostic and formative evaluation; to evaluate the effectiveness of the intervention for preventing misuse of high-risk OTC medications by older adults; and to evaluate the implementation of the intervention in community pharmacies...
January 24, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28126831/erbin-deficiency-links-stat3-and-tgf-%C3%AE-pathway-defects-with-atopy-in-humans
#15
J J Lyons, Y Liu, C A Ma, X Yu, M P O'Connell, M G Lawrence, Y Zhang, K Karpe, M Zhao, A M Siegel, K D Stone, C Nelson, N Jones, T DiMaggio, D N Darnell, E Mendoza-Caamal, L Orozco, J D Hughes, J McElwee, R J Hohman, P A Frischmeyer-Guerrerio, M E Rothenberg, A F Freeman, S M Holland, J D Milner
Nonimmunological connective tissue phenotypes in humans are common among some congenital and acquired allergic diseases. Several of these congenital disorders have been associated with either increased TGF-β activity or impaired STAT3 activation, suggesting that these pathways might intersect and that their disruption may contribute to atopy. In this study, we show that STAT3 negatively regulates TGF-β signaling via ERBB2-interacting protein (ERBIN), a SMAD anchor for receptor activation and SMAD2/3 binding protein...
January 26, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28125004/antioxidant-pre-treatment-reduces-the-toxic-effects-of-oxalate-on-renal-epithelial-cells-in-a-cell-culture-model-of-urolithiasis
#16
Tomislav Kizivat, Martina Smolić, Ivana Marić, Maja Tolušić Levak, Robert Smolić, Ines Bilić Čurčić, Lucija Kuna, Ivan Mihaljević, Aleksandar Včev, Sandra Tucak-Zorić
Urolithiasis is characterized by the formation and retention of solid crystals within the urinary tract. Kidney stones are mostly composed of calcium oxalate, which predominantly generates free radicals that are toxic to renal tubular cells. The aim of the study is to explore possible effects of antioxidant pre-treatment on inhibition of oxidative stress. Three cell lines were used as in vitro model of urolithiasis: MDCK I, MDCK II and LLC-PK1. Oxidative stress was induced by exposure of cells to sodium oxalate in concentration of 8 mM...
January 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28124521/forming-a-stone-in-pelviureteric-junction-obstruction-cause-or-effect
#17
Theodora Stasinou, Andreas Bourdoumis, Junaid Masood
OBJECTIVES: To investigate a possible causal relationship for stone formation in pelviureteric junction obstruction and to outline management options. MATERIALS AND METHODS: A literature search and evidence synthesis was conducted via electronic databases in the English language using the key words pelviureteric junction obstruction; urolithiasis; hyperoxaluria; laparoscopic pyeloplasty; flexible nephroscopy; percutaneous nephrolithotomy, alone or in combination...
January 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28118755/expression-of-heterologous-oxalate-decarboxylase-in-hek293-cells-confers-protection-against-oxalate-induced-oxidative-stress-as-a-therapeutic-approach-for-calcium-oxalate-stone-disease
#18
Abhishek Albert, Vidhi Tiwari, Eldho Paul, Divya Ganesan, Mahesh Ayyavu, Ritu Kujur, Sasikumar Ponnusamy, Kathiresan Shanmugam, Luciano Saso, Selvam Govindan Sadasivam
Oxalates stimulate alterations in renal epithelial cells and thereby induce calcium oxalate (CaOx) stone formation. Bacillus subtilis YvrK gene encodes for oxalate decarboxylase (OxdC) which degrades oxalate to formate and CO2. The present work is aimed to clone the oxdC gene in a mammalian expression vector pcDNA and transfect into Human Embryonic Kidney 293 (HEK293) cells and evaluate the oxdC expression, cell survival rate and oxalate degrading efficiency. The results indicate cell survival rate of HEK293/pcDNAOXDC cells pre-incubated with oxalate was enhanced by 28%...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28114234/effective-selection-of-a-well-differentiated-type-of-human-uterine-endometrial-carcinoma-cells-by-transfection-of-the-sulfotransferase-gene-and-possible-association-of-sulfoglycolipids-with-well-differentiated-phenotypes
#19
Kyoko Tanaka, Isamu Ishiwata, Kaneyuki Kubushiro, Mikio Mikami, Daisuke Aoki, Kazushige Kiguchi, Masao Iwamori
OBJECTIVES: Sulfatide has been shown to be characteristically increased on the apical surface of the normal endometrium at the secretory phase, and to be related with the formation of the glandular structure and the secretion of mucin from glands for the implantation of a fertilized egg. Additionally, sulfatides are expressed in the well-differentiated type, but not in the poorly differentiated type, of endometrial carcinomas. This suggests that sulfatides are a molecular marker of differentiated phenotypes...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28111324/bestrophinopathy-an-rpe-photoreceptor-interface-disease
#20
REVIEW
Karina E Guziewicz, Divya Sinha, Néstor M Gómez, Kathryn Zorych, Emily V Dutrow, Anuradha Dhingra, Robert F Mullins, Edwin M Stone, David M Gamm, Kathleen Boesze-Battaglia, Gustavo D Aguirre
Bestrophinopathies, one of the most common forms of inherited macular degenerations, are caused by mutations in the BEST1 gene expressed in the retinal pigment epithelium (RPE). Both human and canine BEST1-linked maculopathies are characterized by abnormal accumulation of autofluorescent material within RPE cells and bilateral macular or multifocal lesions; however, the specific mechanism leading to the formation of these lesions remains unclear. We now provide an overview of the current state of knowledge on the molecular pathology of bestrophinopathies, and explore factors promoting formation of RPE-neuroretinal separations, using the first spontaneous animal model of BEST1-associated retinopathies, canine Best (cBest)...
January 19, 2017: Progress in Retinal and Eye Research
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