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https://www.readbyqxmd.com/read/29150162/distribution-of-clinical-risk-factors-for-fracture-in-a-brussels-cohort-of-postmenopausal-women-the-frisbee-study-and-comparison-with-other-major-cohort-studies
#1
S I Cappelle, I Ramon, C Dekelver, S Rozenberg, F Baleanu, R Karmali, M Rubinstein, M Tondeur, M Moreau, M Paesmans, P Bergmann, J-J Body
OBJECTIVES: The estimation of fracture risk using clinical risk factors (CRFs) is of primary concern in osteoporosis management, but only some risk factors have been thoroughly evaluated and incorporated in predictive models. We have launched a large prospective study, the 'Fracture Risk Brussels Epidemiological Enquiry' (FRISBEE), to develop a new predictive model for osteoporotic fractures. The aims of this report are to describe the methodology of the FRISBEE study and to compare the distribution of CRFs in our cohort with those reported in other large studies...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29149904/concomitant-sequential-and-7-day-triple-therapy-in-first-line-treatment-of-helicobacter-pylori-infection-in-korea-study-protocol-for-a-randomized-controlled-trial
#2
Hyuk Lee, Beom Jin Kim, Sang Gyun Kim, Jin Il Kim, Il Ju Choi, Yong Chan Lee, Jae G Kim, Jae J Kim
BACKGROUND: Most international guidelines recommend triple-therapy regimens consisting of a proton pump inhibitor, clarithromycin, and amoxicillin/metronidazole for at least 7 days for the eradication of Helicobacter pylori. However, the efficacy of 7-day clarithromycin-based standard triple therapy for H. pylori infection is currently unacceptable in Korea. In this study, we will compare the efficacy and safety of 7-day standard triple therapy, 10-day sequential therapy, and 10-day concomitant therapy for the first-line treatment of H...
November 17, 2017: Trials
https://www.readbyqxmd.com/read/29149805/observational-cohort-study-safety-outcomes-in-children-using-proton-pump-inhibitors-or-histamine-2-receptor-antagonists
#3
Eline Houben, Saga Johansson, Péter Nagy, Fernie J A Penning-van Beest, Ernst J Kuipers, Ron M C Herings
OBJECTIVE: Acid suppression with histamine-2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) is recommended for children with persistent gastroesophageal reflux disease symptoms. In this retrospective, observational postauthorization study, we aimed to assess and compare safety outcomes in pediatric first-time users of esomeprazole, other PPIs, or H2RAs. METHODS: Data on children (aged 0-18 years) first dispensed esomeprazole, other PPIs, or H2RAs between September 2008 and August 2011 were obtained from the Dutch PHARMO Database Network...
November 17, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29148878/molecular-characterization-of-fluoroquinolone-resistance-mechanisms-of-campylobacter-isolates-from-duck-meats
#4
Min Kang, Bai Wei, Sung-Woon Choi, Se-Yeoun Cha, Hyung-Kwan Jang
The purpose of this study was to identify the molecular basis of quinolone resistance of Campylobacter isolates recovered from duck meats. Sixty-one isolates from duck meat samples were studied using sequence analysis of the gyrA gene, and PCR assays were used to identify the presence of the CmeABC efflux pump and its restored sensitivity in the presence of efflux-pump inhibitors. High-level resistance to nalidixic acid and ciprofloxacin was attributed to amino acid substitutions Thr-86-Ile in some isolates...
November 17, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29146106/the-hydrophobic-trap-the-achilles-heel-of-rnd-efflux-pumps
#5
Zachary Aron, Timothy J Opperman
Resistance-nodulation-division (RND) superfamily efflux pumps play a major role in multidrug resistance (MDR) of Gram-negative pathogens by extruding diverse classes of antibiotics from the cell. There has been considerable interest in developing efflux pump inhibitors (EPIs) of RND pumps as adjunctive therapies. The primary challenge in EPI discovery has been the highly hydrophobic, poly-specific substrate binding site of the target. Recent findings have identified the hydrophobic trap, a narrow phenylalanine-lined groove in the substrate-binding site, as the "Achilles heel" of the RND efflux pumps...
November 13, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/29145976/not-only-p-glycoprotein-amplification-of-the-abcb1-containing-chromosome-region-7q21-confers-multidrug-resistance-upon-cancer-cells-by-coordinated-overexpression-of-an-assortment-of-resistance-related-proteins
#6
Ilaria Genovese, Andrea Ilari, Yehuda G Assaraf, Francesco Fazi, Gianni Colotti
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance mechanism for a plethora of cancer chemotherapeutics including for example taxenes, anthracyclines, Vinca alkaloids, and epipodopyllotoxins, demonstrated by a large array of published papers, both in tumor cell lines and in a variety of tumors, including various solid tumors and hematological malignancies...
May 2017: Drug Resistance Updates: Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
https://www.readbyqxmd.com/read/29144559/treatment-of-helicobacter-pylori-infection-a-clinical-practice-update
#7
REVIEW
Rocco Maurizio Zagari, Stefano Rabitti, Leonardo Henry Eusebi, Franco Bazzoli
BACKGROUND: Helicobacter pylori infection is still frequent in the community and all infected subjects should be offered an eradication therapy. Nowdays physicians have to face the challenge of antibiotic resistance in treating Helicobacter pylori infected individuals. AIM: This review provides an overview of current international guidelines and reports recent evidence from systematic reviews and clinical trials on the treatment of Helicobacter pylori infection, and should help physicians to better treat their patients...
November 16, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29142181/treatment-strategy-for-standard-dose-proton-pump-inhibitor-resistant-reflux-esophagitis
#8
Katsuhiko Iwakiri
Reflux esophagitis is characterized by excessive esophageal acid exposure. To treat reflux esophagitis, it is necessary to reduce excessive esophageal acid exposure to within the normal range. The first-line drug for the treatment of reflux esophagitis is a standard-dose proton-pump inhibitor (PPI), which is also recommended by the Evidence-based Clinical Practice Guidelines 2015 for gastroesophageal disease of the Japanese Society of Gastroenterology. It has been reported that the response to a standard dose of PPI in patients with mild reflux esophagitis is 90-100%, and that in patients with severe reflux esophagitis is 80-85%...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29141268/gastric-adenocarcinoma-and-proximal-polyposis-of-the-stomach-gapps-a-rare-recently-described-gastric-polyposis-syndrome-report-of-a-case
#9
Andrea Beer, Berthold Streubel, Reza Asari, Clemens Dejaco, Georg Oberhuber
In rare cases with multiple gastric polyps in the corpus and fundus, a recently described gastric polyposis syndrome called gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) has to be considered. We report on the findings in a patient fulfilling the criteria of this disease.A female patient born in 1977 underwent gastroscopy in 2005 due to recurrent abdominal pain. Endoscopy revealed more than 100 fundic gland polyps in the corpus and fundus. An ileocolonoscopy was inconspicuous. The patient did not take proton pump inhibitors...
November 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29139255/-association-rules-analysis-for-exploring-combined-medication-characteristics-of-fufang-kushen-injection-real-world-study-based-on-49-597-cases
#10
Yin Zhang, Yan-Ming Xie, Yan-Nan Li, Chang Zhang, Cen Chen, Yan Zhuang
The present study aimed to analyze the association rules of Fufang Kushen injection in combined medications in the real world based on electrical medical records in hospital information system, and provide reference for its reasonable clinical application. The electrical medical records of the hospitalized patients using Fufang Kushen injection were extracted to analyze the frequency distribution characteristics in combined application with Western medicine, and analyze the specific association rules between these combinations by using Apriori algorithm...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29139202/lego-inspired-drug-design-unveiling-of-the-novel-class-of-benzo-d-thiazole-containing-a-3-4-dihydroxyphenyl-moiety-as-plasma-membrane-h-atpase-inhibitors
#11
Truong Thanh Tung, Dao Trong Tuan, Marta Grifell Junyent, Michael Palmgren, Thomas Günther-Pomorski, Anja Thoe Fuglsang, Søren Brøgger Christensen, John Nielsen
The fungal plasma membrane H+-ATPase (Pma1p) is a potential target for the discovery of new antifungal agents. Surprisingly, no structure-activity relationship studies for small molecules targeting Pma1p have been reported. Herein, we disclose a LEGO-inspired fragment assembly strategy for design, synthesis and discovery of benzo[d]thiazoles containing a 3,4-dihydroxyphenyl moiety as potential Pma1p inhibitors. A series of 2-(benzo[d]thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanones was found to inhibit Pma1p with the most potent IC50 of 8 µM in an in vitro plasma membrane H+-ATPase assay...
November 15, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29139189/clostridium-difficile-infection-in-hospitalized-octogenarian-patients
#12
Anca Trifan, Irina Girleanu, Carol Stanciu, Egidia Miftode, Camelia Cojocariu, Ana-Maria Singeap, Catalin Sfarti, Stefan Chiriac, Tudor Cuciureanu, Oana Stoica
AIM: To evaluate the risk factors and outcome of Clostridium difficile infection in hospitalized octogenarian patients. METHODS: A retrospective analysis of risk factors and outcome of C. difficile infection in hospitalized octogenarians was carried out at two academic centers in Romania from January 2014 to September 2016. Demographic, clinical and laboratory characteristics; antibiotics and proton pump inhibitors use in-hospital and 2 months before admission; comorbidities; length of hospital stay; treatment; and outcome were carefully collected from the patients' medical charts and compared with those from octogenarians hospitalized during the same period...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29136587/management-of-eosinophilic-esophagitis-and-celiac-disease
#13
REVIEW
Rok Seon Choung, Jeffrey A Alexander, David A Katzka, Joseph A Murray
Eosinophilic esophagitis (EoE) and celiac disease (CeD) are chronic immune mediated gastrointestinal disorders characterized by mucosal inflammation, both of which are related to food antigens, but with differences in clinical and histopathological features. When untreated, both diseases lead to destruction of the epithelium. While a strict gluten-free diet is the only effective therapy for CeD, several therapeutic options, such as proton pump inhibitors, topical steroids and diet elimination therapy are available for EoE...
November 10, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29134635/ribociclib-bioavailability-is-not-affected-by-gastric-ph-changes-or-food-intake-in-silico-and-clinical-evaluations
#14
Tanay S Samant, Shyeilla Dhuria, Yasong Lu, Marc Laisney, Shu Yang, Arnaud Grandeury, Martin Mueller-Zsigmondy, Kenichi Umehara, Felix Huth, Michelle Miller, Caroline Germa, Mohamed Elmeliegy
Ribociclib (KISQALI®), a cyclin-dependent kinase 4/6 inhibitor approved for the first-line treatment of HR+/HER2- advanced breast cancer with an aromatase inhibitor, is administered with no restrictions on concomitant gastric pH-elevating agents or food intake. The influence of proton pump inhibitors (PPIs) on ribociclib bioavailability was assessed using (1) biorelevant media solubility, (2) physiologically based pharmacokinetic (PBPK) modeling, (3) non-compartmental analysis (NCA) of clinical trial data, and (4) population PK (PopPK) analysis...
November 14, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29134629/proton-pump-inhibitor-use-and-dementia-risk-prospective-population-based-study
#15
Shelly L Gray, Rod L Walker, Sascha Dublin, Onchee Yu, Erin J Aiello Bowles, Melissa L Anderson, Paul K Crane, Eric B Larson
OBJECTIVES: To determine whether higher cumulative proton pump inhibitor (PPI) exposure is associated with greater dementia risk. DESIGN: Prospective population-based cohort study. SETTING: Kaiser Permanente Washington, an integrated healthcare delivery system in Seattle, Washington. PARTICIPANTS: Individuals aged 65 and older without dementia at study entry (N = 3,484). MEASUREMENTS: Participants were screened for dementia every 2 years, and those who screened positive underwent extensive evaluation...
November 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29134626/proton-pump-inhibitor-therapy-and-dementia-what-is-the-evidence
#16
EDITORIAL
Yu-Xiao Yang
No abstract text is available yet for this article.
November 14, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29133389/selective-killing-of-helicobacter-pylori-with-ph-responsive-helix-coil-conformation-transitionable-antimicrobial-polypeptides
#17
Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M Peek, Lichen Yin, Lin-Feng Chen, Jianjun Cheng
Current clinical treatment of Helicobacter pylori infection, the main etiological factor in the development of gastritis, gastric ulcers, and gastric carcinoma, requires a combination of at least two antibiotics and one proton pump inhibitor. However, such triple therapy suffers from progressively decreased therapeutic efficacy due to the drug resistance and undesired killing of the commensal bacteria due to poor selectivity. Here, we report the development of antimicrobial polypeptide-based monotherapy, which can specifically kill H...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29133286/eosinophilic-esophagitis-update-on-management-and-controversies
#18
REVIEW
Joan W Chen, John Y Kao
Eosinophilic esophagitis is a chronic allergen driven immune mediated disease that is increasingly recognized as a leading cause of dysphagia and foregut symptoms in children and adults. Much knowledge has been gained in recent years on the genetic and environmental risk factors for this disease, the associated inflammatory milieu, and the long term complications from esophageal remodeling. In this review we will highlight recent progress made in research into this disease, focusing on adults. We will discuss ongoing efforts to develop a minimally invasive technique that may obviate the need for repeated endoscopic assessment of disease activity...
November 13, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29132706/putting-proton-pump-inhibitors-into-perspective
#19
William Simonson
No abstract text is available yet for this article.
November 10, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/29132520/gastroesophageal-reflux-disease
#20
REVIEW
Rick Kellerman, Thomas Kintanar
Gastroesophageal reflux disease (GERD) is a gastrointestinal motility disorder that results from the reflux of stomach contents into the esophagus or oral cavity resulting in symptoms or complications. The typical symptoms of GERD are heartburn and regurgitation of gastric contents into the oropharynx. GERD affects quality of life and may cause erosive esophagitis, esophageal strictures, and Barrett esophagus, a precursor to esophageal adenocarcinoma. GERD is a clinical diagnosis and is most effectively treated with proton-pump inhibitors (PPIs)...
December 2017: Primary Care
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