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"Lung Rescue"

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https://www.readbyqxmd.com/read/28859094/epithelial-heparan-sulfate-regulates-sonic-hedgehog-signaling-in-lung-development
#1
Hua He, Meina Huang, Shenfei Sun, Yihui Wu, Xinhua Lin
The tree-like structure of the mammalian lung is generated from branching morphogenesis, a reiterative process that is precisely regulated by numerous factors. How the cell surface and extra cellular matrix (ECM) molecules regulate this process is still poorly understood. Herein, we show that epithelial deletion of Heparan Sulfate (HS) synthetase Ext1 resulted in expanded branching tips and reduced branching number, associated with several mesenchymal developmental defects. We further demonstrate an expanded Fgf10 expression and increased FGF signaling activity in Ext1 mutant lungs, suggesting a cell non-autonomous mechanism...
August 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28857905/incidence-of-cannula-associated-deep-vein-thrombosis-after-veno-venous-extracorporeal-membrane-oxygenation
#2
Jay Menaker, Ali Tabatabai, Raymond Rector, Katelyn Dolly, Joseph Kufera, Eugenia Lee, Zachary Kon, Pablo Sanchez, Si Pham, Daniel L Herr, Michael Mazzeffi, Ronald P Rabinowitz, James V O'Connor, Deborah M Stein, Thomas M Scalea
Limited literature regarding the incidence of cannula-associated deep vein thrombosis (CaDVT) after veno-venous extracorporeal membrane oxygenation (VV ECMO) exists. The purpose of this study was to identify the incidence of post decannulation CaDVT and identify any associated risk factors. Forty-eight patients were admitted between August 2014 and January 2016 to the Lung Rescue Unit were included in the study. Protocolized anticoagulation levels (partial thromboplastin time [PTT] 45-55 seconds) and routine post decannulation DVT screening were in place during the study period...
September 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28846578/the-lung-rescue-unit-does-a-dedicated-intensive-care-unit-for-venovenous-extracorporeal-membrane-oxygenation-improve-survival-to-discharge
#3
Jay Menaker, Katelyn Dolly, Raymond Rector, Joseph Kufera, Eugenia E Lee, Ali Tabatabai, Ronald P Rabinowitz, Zachary N Kon, Pablo Sanchez, Si Pham, Daniel L Herr, James V O'Connor, Deborah M Stein, Thomas M Scalea
BACKGROUND: The use of venovenous extra corporeal membrane oxygenation (VV ECMO) for acute respiratory failure (ARF)/acute respiratory (ARDS) has increased since 2009. Specialized units for patients requiring VV ECMO are not standard and patients are often cohorted with other critically ill patients. The purpose of this study was to report the outcome of adult patients admitted in 2015 to the lung rescue unit, which, to our knowledge, is the first intensive care unit in the United States that has been specifically created to provide care for patients requiring VV ECMO...
September 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28669500/one-year-experience-with-a-mobile-extracorporeal-life-support-service
#4
Jacob Gutsche, William Vernick, Todd A Miano
BACKGROUND: Severe acute respiratory distress syndrome is associated with a high mortality rate. The International Extracorporeal Membrane Oxygenation Network recommends regionalization of extracorporeal life support (ECLS) to high-volume centers and development of mobile ECLS teams to rescue patients with severe acute respiratory disease. METHODS: A tertiary medical center developed a mobile team and the infrastructure to support a ECLS transport service available 24 hours a day, 7 days a week...
June 29, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28422919/the-lung-rescue-unit-lru-does-a-dedicated-intensive-care-unit-for-veno-venous-extra-corporeal-membrane-oxygenation-vv-ecmo-improve-survival-to-discharge
#5
Jay Menaker, Katelyn Dolly, Raymond Rector, Joseph Kufera, Eugenia E Lee, Ali Tabatabai, Ronald P Rabinowitz, Zachary Kon, Pablo Sanchez, Si Pham, Daniel L Herr, James V O'Connor, Deborah M Stein, Thomas M Scalea
BACKGROUND: The use of veno-venous extra corporeal membrane oxygenation (VV ECMO) for acute respiratory failure/distress syndrome (ARF/ARDS) has increased since 2009. Specialized units for patients requiring VV ECMO are not standard and patients are often cohorted with other critically ill patients. The purpose of this study was to report the outcome of adult patients admitted in 2015 to the LRU, which, to our knowledge, is the first intensive care unit in the United States that has been specifically created to provide care for patients requiring VV ECMO...
April 18, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28198716/incidence-of-cannula-associated-deep-vein-thrombosis-after-veno-venous-ecmo
#6
Jay Menaker, Ali Tabatabai, Raymond Rector, Katelyn Dolly, Joseph Kufera, Eugenia Lee, Zachary Kon, Pablo Sanchez, Si Pham, Daniel L Herr, Michael Mazzeffi, Ronald P Rabinowitz, James V OʼConnor, Deborah M Stein, Thomas M Scalea
Limited literature regarding the incidence of cannula associated deep vein thrombosis (CaDVT) following veno-venous extracorporeal membrane oxygenation (VV ECMO) exists. The purpose of this study was to identify the incidence of post decannulation CaDVT and identify any associated risk factors. Forty eight patients were admitted between August 2014 and January 2016 to the Lung Rescue Unit were included in the study. Protocolized anticoagulation levels (partial thromboplastin time 45-55 second) and routine post decannulation DVT screening were in place during the study period...
February 13, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/24963038/apolipoprotein-a-i-mimetic-peptide-4f-rescues-pulmonary-hypertension-by-inducing-microrna-193-3p
#7
Salil Sharma, Soban Umar, Francois Potus, Andrea Iorga, Gabriel Wong, David Meriwether, Sandra Breuils-Bonnet, Denise Mai, Kaveh Navab, David Ross, Mohamad Navab, Steeve Provencher, Alan M Fogelman, Sébastien Bonnet, Srinivasa T Reddy, Mansoureh Eghbali
BACKGROUND: Pulmonary arterial hypertension is a chronic lung disease associated with severe pulmonary vascular changes. A pathogenic role of oxidized lipids such as hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids is well established in vascular disease. Apolipoprotein A-I mimetic peptides, including 4F, have been reported to reduce levels of these oxidized lipids and improve vascular disease. However, the role of oxidized lipids in the progression of pulmonary arterial hypertension and the therapeutic action of 4F in pulmonary arterial hypertension are not well established...
August 26, 2014: Circulation
https://www.readbyqxmd.com/read/21795885/closing-the-care-in-the-air-capability-gap-for-severe-lung-injury-the-landstuhl-acute-lung-rescue-team-and-extracorporeal-lung-support
#8
Raymond Fang, Patrick F Allan, Shannon G Womble, Morris T Porter, Johana Sierra-Nunez, Richard S Russ, Gina R Dorlac, Clayne Benson, John S Oh, Sandra M Wanek, Erik C Osborn, Stephen V Silvey, Warren C Dorlac
BACKGROUND: The success of US Air Force Critical Care Air Transport Teams (CCATT) in transporting critically ill and injured patients enabled changes in military medical force deployment and casualty care practice. Even so, a subset of casualties remains who exceed even CCATT capabilities for movement. These patients led to the creation of the Landstuhl Acute Lung Rescue Team (ALeRT) to close the "care in the air" capability gap. METHODS: The ALeRT Registry was queried for the period between November 1, 2005, and June 30, 2010...
July 2011: Journal of Trauma
https://www.readbyqxmd.com/read/19822627/critically-ill-patients-with-2009-influenza-a-h1n1-infection-in-canada
#9
Anand Kumar, Ryan Zarychanski, Ruxandra Pinto, Deborah J Cook, John Marshall, Jacques Lacroix, Tom Stelfox, Sean Bagshaw, Karen Choong, Francois Lamontagne, Alexis F Turgeon, Stephen Lapinsky, Stéphane P Ahern, Orla Smith, Faisal Siddiqui, Philippe Jouvet, Kosar Khwaja, Lauralyn McIntyre, Kusum Menon, Jamie Hutchison, David Hornstein, Ari Joffe, Francois Lauzier, Jeffrey Singh, Tim Karachi, Kim Wiebe, Kendiss Olafson, Clare Ramsey, Sat Sharma, Peter Dodek, Maureen Meade, Richard Hall, Robert A Fowler
CONTEXT: Between March and July 2009, the largest number of confirmed cases of 2009 influenza A(H1N1) infection occurred in North America. OBJECTIVE: To describe characteristics, treatment, and outcomes of critically ill patients in Canada with 2009 influenza A(H1N1) infection. DESIGN, SETTING, AND PATIENTS: A prospective observational study of 168 critically ill patients with 2009 influenza A(H1N1) infection in 38 adult and pediatric intensive care units (ICUs) in Canada between April 16 and August 12, 2009...
November 4, 2009: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/19703903/crosstalk-between-protease-activated-receptor-1-and-platelet-activating-factor-receptor-regulates-melanoma-cell-adhesion-molecule-mcam-muc18-expression-and-melanoma-metastasis
#10
Vladislava O Melnikova, Krishnakumar Balasubramanian, Gabriel J Villares, Andrey S Dobroff, Maya Zigler, Hua Wang, Frederik Petersson, Janet E Price, Alan Schroit, Victor G Prieto, Mien-Chie Hung, Menashe Bar-Eli
The cellular and molecular pathways that regulate platelet activation, blood coagulation, and inflammation are emerging as critical players in cancer progression and metastasis. Here, we demonstrate a novel signaling mechanism whereby protease-activated receptor 1 (PAR1) mediates expression of melanoma cell adhesion molecule MCAM/MUC18 (MUC18), a critical marker of melanoma metastasis, via activation of platelet-activating factor receptor (PAFR) and cAMP-responsive element-binding protein (CREB). We found that PAR1 silencing with small hairpin RNA inhibits MUC18 expression in metastatic melanoma cells by inhibiting CREB phosphorylation, activity, and binding to the MUC18 promoter...
October 16, 2009: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/19359961/air-transport-of-patients-with-severe-lung-injury-development-and-utilization-of-the-acute-lung-rescue-team
#11
Gina R Dorlac, Raymond Fang, Valerie M Pruitt, Peter A Marco, Heidi M Stewart, Stephen L Barnes, Warren C Dorlac
BACKGROUND: Critical Care Air Transport Teams (CCATTs) are an integral component of modern casualty care, allowing early transport of critically ill and injured patients. Aeromedical evacuation of patients with significant pulmonary impairment is sometimes beyond the scope of CCATT because of limitations of the transport ventilator and potential for further respiratory deterioration in flight. The Acute Lung Rescue Team (ALRT) was developed to facilitate transport of these patients out of the combat theater...
April 2009: Journal of Trauma
https://www.readbyqxmd.com/read/18808407/intentional-abo-incompatible-lung-transplantation
#12
M Strüber, G Warnecke, C Hafer, L Goudeva, C Fegbeutel, S Fischer, J Gottlieb, M Avsar, A R Simon, A Haverich
We report on a case of intentional blood group incompatible lung transplantation. A blood group O cystic fibrosis patient was mechanically ventilated and put on interventional lung assist for severe respiratory decompensation. Since timely allocation of a blood group O donor lung was impossible, an AB deceased donor lung rescue allocation was accepted and the transplant performed using a pre-, peri- and postoperative antibody depletion protocol including plasmapheresis, ivIg administration, rituximab and immunoadsorption...
November 2008: American Journal of Transplantation
https://www.readbyqxmd.com/read/12215028/challenging-embryological-theories-on-congenital-diaphragmatic-hernia-future-therapeutic-implications-for-paediatric-surgery
#13
E C Jesudason
Lung hypoplasia is central to the poor prognosis of babies with congenital diaphragmatic hernia (CDH). Prolapse of abdominal organs through a diaphragmatic defect has traditionally been thought to impair lung growth by compression. The precise developmental biology of CDH remains unresolved. Refractory to fetal correction, lung hypoplasia in CDH may instead originate during embryogenesis and before visceral herniation. Resolving these conflicting hypotheses may lead to reappraisal of current clinical strategies...
July 2002: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/11083978/-high-frequency-oscillatory-ventilation-in-pediatric-patients-protocol-and-preliminary-results
#14
F Martinón Torres, A Rodríguez Núñez, D G Jaimovich, J M Martinón Sánchez
BACKGROUND: High-frequency oscillatory ventilation (HFOV) constitutes an important advance in the management of children with respiratory failure. Although it has been used mainly as "lung rescue therapy", pediatric indications for HFOV can be broader. The principal advantages of this modality compared with conventional ventilation are the lower incidence of barotrauma, volutrauma, atelectrauma and biotrauma. To date, experience with HFOV in our country has been scarce and limited to neonatal patients...
October 2000: Anales Españoles de Pediatría
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