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Sarah Massalkhi, M Agúndez, J Cernicharo, L Velilla Prieto, J R Goicoechea, G Quintana-Lacaci, J P Fonfría, J Alcolea, V Bujarrabal
Context: Silicon carbide dust is ubiquitous in circumstellar envelopes around C-rich AGB stars. However, the main gas-phase precursors leading to the formation of SiC dust have not yet been identified. The most obvious candidates among the molecules containing an Si-C bond detected in C-rich AGB stars are SiC2 , SiC, and Si2 C. To date, the ring molecule SiC2 has been observed in a handful of evolved stars, while SiC and Si2 C have only been detected in the C-star envelope IRC +10216...
March 2018: Astronomy and Astrophysics
J Cernicharo, M Agúndez, L Velilla Prieto, M Guélin, J R Pardo, C Kahane, C Marka, C Kramer, S Navarro, G Quintana-Lacaci, J P Fonfría, N Marcelino, B Tercero, E Moreno, S Massalkhi, M Santander-García, M C McCarthy, C A Gottlieb, J L Alonso
We report the discovery in space of methyl silane, CH3 SiH3 , from observations of ten rotational transitions between 80 and 350 GHz ( J u from 4 to 16) with the IRAM 30 m radio telescope. The molecule was observed in the envelope of the C-star IRC +10216. The observed profiles and our models for the expected emission of methyl silane suggest that the it is formed in the inner zones of the circumstellar envelope, 1-40 R * , with an abundance of (0.5-1) × 10-8 relative to H2 . We also observed several rotational transitions of silyl cyanide (SiH3 CN), confirming its presence in IRC +10216 in particular, and in space in general...
October 2017: Astronomy and Astrophysics
M Agúndez, J Cernicharo, G Quintana-Lacaci, A Castro-Carrizo, L Velilla Prieto, N Marcelino, M Guélin, C Joblin, J A Martín-Gago, C A Gottlieb, N A Patel, M C McCarthy
Linear carbon chains are common in various types of astronomical molecular sources. Possible formation mechanisms involve both bottom-up and top-down routes. We have carried out a combined observational and modeling study of the formation of carbon chains in the C-star envelope IRC +10216, where the polymerization of acetylene and hydrogen cyanide induced by ultraviolet photons can drive the formation of linear carbon chains of increasing length. We have used ALMA to map the emission of λ 3 mm rotational lines of the hydrocarbon radicals C2H, C4H, and C6H, and the CN-containing species CN, C3N, HC3N, and HC5N with an angular resolution of ~1″...
May 2017: Astronomy and Astrophysics
Yuqiong Dai, Hao Sun, Sunirmal Pal, Yunlu Zhang, Sangwoo Park, Christopher P Kabb, Wei David Wei, Brent S Sumerlin
Responsive systems sensitive to near-infrared (NIR) light are promising for triggered release due to efficient deep tissue penetration of NIR irradiation relative to higher energy sources (e.g., UV), allowing for spatiotemporal control over triggering events with minimal potential for tissue damage. Herein, we report star polymers containing thermally-labile azo linkages that dissociate during conventional heating or during localized heating via the photothermal effect upon NIR irradiation. Controlled release during conventional heating was investigated for the star polymers loaded with a model dye, with negligible release being observed at 25 °C and >80% release at 90 °C...
March 1, 2017: Chemical Science
Ryan A Brady, Nicholas J Brooks, Pietro Cicuta, Lorenzo Di Michele
Many emerging technologies require materials with well-defined three-dimensional nanoscale architectures. Production of these structures is currently underpinned by self-assembling amphiphilic macromolecules or engineered all-DNA building blocks. Both of these approaches produce restricted ranges of crystal geometries due to synthetic amphiphiles' simple shape and limited specificity, or the technical difficulties in designing space-filling DNA motifs with targeted shapes. We have overcome these limitations with amphiphilic DNA nanostructures, or "C-Stars", that combine the design freedom and facile functionalization of DNA-based materials with robust hydrophobic interactions...
April 20, 2017: Nano Letters
Michelle R Iannacone, Sudipta Sinnya, Nirmala Pandeya, Nikky Isbel, Scott Campbell, Jonathan Fawcett, Peter H Soyer, Lisa Ferguson, Marcia Davis, David C Whiteman, Adèle C Green
The increased skin cancer incidence in organ transplant recipients is well-known, but the skin cancer burden at any one time is unknown. Our objective was to estimate the period prevalence of untreated skin malignancy and actinic keratoses in high-risk kidney and liver transplant recipients and to assess associated factors. Organ transplant recipients underwent full skin examinations by dermatologically trained physicians. The proportion of examined organ transplant recipients with histopathologically confirmed skin cancer in the 3-month baseline period was estimated...
July 2016: Journal of Investigative Dermatology
Seth C Burkert, Alexander Star
Carbon nanomaterials have been proposed as effective drug delivery devices; however their perceived biopersistence and toxicological profile may hinder their applications in medical therapeutics. Nitrogen doping of carbon nanotubes results in a unique "stacked-cup" structure, with cups held together through van der Waals forces. Disrupting these weak interactions yields individual and short-stacked nanocups that can subsequently be corked with gold nanoparticles, resulting in sealed containers for delivery of cargo...
December 2, 2015: Current Protocols in Chemical Biology
M Nosè, I Bighelli, M Castellazzi, G Martinotti, G Carrà, C Lucii, G Ostuzzi, F Sozzi, C Barbui
AIMS: In recent years several warnings have been issued by regulatory authorities on the risk of electrocardiogram abnormalities in individuals exposed to psychotropic drugs. As a consequence of these warnings, monitoring of the QT interval corrected for heart rate (QTc) has become increasingly common. This study was conducted to measure the frequency of QTc prolongation in unselected psychiatric patients, and to document the associated factors using a cross-sectional approach. METHOD: The study was carried out in 35 Italian psychiatric services that are part of the STAR (Servizi Territoriali Associati per la Ricerca) Network, a research group established to produce scientific knowledge by collecting data under ordinary circumstances...
October 15, 2015: Epidemiology and Psychiatric Sciences
Michelle R Iannacone, Nirmala Pandeya, Nicole Isbel, Scott Campbell, Jonathan Fawcett, H Peter Soyer, Lisa Ferguson, Marcia Davis, David C Whiteman, Adèle C Green
BACKGROUND: Organ transplant recipients (OTRs) have a high risk of skin cancer, and excessive sun exposure is a major contributing factor. OBJECTIVE: To document the prevalence of sun protection and associated factors in OTRs in Queensland, Australia. METHODS: Cross-sectional study of the frequency of wearing hats, long sleeves and using sunscreens among OTRs and factors associated with regular use. Adjusted prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using Poisson regression models...
2015: Dermatology: International Journal for Clinical and Investigative Dermatology
Haifeng Dong, Yong Zhao, Yifan Tang, Seth C Burkert, Alexander Star
We demonstrate a facile synthesis of different nanostructures by oxidative unzipping of stacked nitrogen-doped carbon nanotube cups (NCNCs). Depending on the initial number of stacked-cup segments, this method can yield graphene nanosheets (GNSs) or hybrid nanostructures comprised of graphene nanoribbons partially unzipped from a central nanotube core. Due to the stacked-cup structure of as-synthesized NCNCs, preventing complete exposure of graphitic planes, the unzipping mechanism is hindered, resulting in incomplete unzipping; however, individual, separated NCNCs are completely unzipped, yielding individual nitrogen-doped GNSs...
May 27, 2015: ACS Applied Materials & Interfaces
Kaladhar Kamalasanan, Riccardo Gottardi, Susheng Tan, Yanan Chen, Bhaskar Godugu, Sam Rothstein, Anna C Balazs, Alexander Star, Steven R Little
The shorter, the more dispersible: An iterative, emulsion-based shortening technique has been used to reduce the length of single-walled carbon nanotubes (SWNTs) to the same order of magnitude as their diameter (ca. 1 nm), thus achieving an effectively "zero-dimensional" structure with improved dispersibility and, after hydroxylation, long-term water solubility. Finally, zero-dimensional SWNTs were positively identified using mass spectrometry for the first time.
October 18, 2013: Angewandte Chemie
Mengning Ding, Dan C Sorescu, Alexander Star
The unique physical and chemical properties of single-walled carbon nanotubes (SWNTs) make them ideal building blocks for the construction of hybrid nanostructures. In addition to increasing the material complexity and functionality, SWNTs can probe the interfacial processes in the hybrid system. In this work, SWNT-TiO2 core/shell hybrid nanostructures were found to exhibit unique electrical behavior in response to UV illumination and acetone vapors. By experimental and theoretical studies of UV and acetone sensitivities of different SWNT-TiO2 hybrid systems, we established a fundamental understanding on the interfacial charge transfer between photoexcited TiO2 and SWNTs as well as the mechanism of acetone sensing...
June 19, 2013: Journal of the American Chemical Society
Chad M Thorson, Joseph J Dubose, Peter Rhee, Thomas E Knuth, Warren C Dorlac, Jeffrey A Bailey, George D Garcia, Mark L Ryan, Robert M Van Haren, Kenneth G Proctor
In the late 1990s, a Department of Defense subcommittee screened more than 100 civilian trauma centers according to the number of admissions, percentage of penetrating trauma, and institutional interest in relation to the specific training missions of each of the three service branches. By the end of 2001, the Army started a program at University of Miami/Ryder Trauma Center, the Navy began a similar program at University of Southern California/Los Angeles County Medical Center, and the Air Force initiated three Centers for the Sustainment of Trauma and Readiness Skills (C-STARS) at busy academic medical centers: R...
December 2012: Journal of Trauma and Acute Care Surgery
Marie-Jet Bekkers, Sharon A Simpson, Frank Dunstan, Kerry Hood, Monika Hare, John Evans, Christopher C Butler
BACKGROUND: The Stemming the Tide of Antibiotic Resistance (STAR) Educational Program aims to enhance the quality of antibiotic prescribing and raise awareness about antibiotic resistance among general medical practitioners. It consists of a seven part, theory-based blended learning program that includes online reflection on clinicians' own practice, presentation of research evidence and guidelines, a practice-based seminar focusing on participants' own antibiotic prescribing and resistance rates in urine samples sent from their practice, communication skills training using videos of simulated patients in routine surgeries, and participation in a web forum...
May 7, 2010: BMC Family Practice
Denise A Gonzales, Kelly J Norsworthy, Steven J Kern, Steve Banks, Pamela C Sieving, Robert A Star, Charles Natanson, Robert L Danner
BACKGROUND: Meta-analyses of N-acetylcysteine (NAC) for preventing contrast-induced nephrotoxicity (CIN) have led to disparate conclusions. Here we examine and attempt to resolve the heterogeneity evident among these trials. METHODS: Two reviewers independently extracted and graded the data. Limiting studies to randomized, controlled trials with adequate outcome data yielded 22 reports with 2746 patients. RESULTS: Significant heterogeneity was detected among these trials (I2 = 37%; p = 0...
November 14, 2007: BMC Medicine
Zhong-tian Liu, Rrui-zhen Zhao, Yong-heng Zhao, Fu-chao Wu
The LAMOST project, the world largest sky survey project, urgently needs an automatic late-type stars detection system. However, to our knowledge, no effective methods for automatic late-type stars detection have been reported in the literature up to now. The present study work is intended to explore possible ways to deal with this issue. Here, by "late-type stars" we mean those stars with strong molecule absorption bands, including oxygen-rich M, L and T type stars and carbon-rich C stars. Based on experimental results, the authors find that after a wavelet transform with 5 scales on the late-type stars spectra, their frequency spectrum of the transformed coefficient on the 5th scale consistently manifests a unimodal distribution, and the energy of frequency spectrum is largely concentrated on a small neighborhood centered around the unique peak...
July 2005: Guang Pu Xue Yu Guang Pu Fen Xi, Guang Pu
L S Lohmander, D McKeith, O Svensson, M Malmenäs, L Bolin, A Kalla, G Genti, J Szechinski, C Ramos-Remus et al.
OBJECTIVE: To evaluate the gastrointestinal safety and efficacy of the COX inhibiting nitric oxide donator AZD3582 in patients with hip or knee osteoarthritis. METHODS: 970 patients were randomised (7:7:2) to AZD3582 750 mg twice daily, naproxen 500 mg twice daily, or placebo twice daily in a double blind study. The primary end point was the six week incidence of endoscopic gastroduodenal ulcers (diameter > or =3 mm). Overall damage measured on the Lanza scale was a secondary end point...
March 2005: Annals of the Rheumatic Diseases
Jeffrey P Northrop, Mark Bednarski, Susan O Barbieri, Amy T Lu, Dee Nguyen, John Varadarajan, Maureen Osen, King C Li, Josh Star-Lack
Imaging of gene expression in vivo has many potential uses for biomedical research and drug discovery, ranging from the study of gene regulation and cancer to the non-invasive assessment of gene therapies. To streamline the development of imaging marker gene technologies for nuclear medicine, we propose a new approach to the design of reporter/probe pairs wherein the reporter is a cell surface-expressed single chain antibody variable fragment that has been raised against a low molecular weight imaging probe with optimized pharmacokinetic properties...
September 2003: European Journal of Nuclear Medicine and Molecular Imaging
A J Smith, E J Armijo, J J Stowitschek
Recent interest in case management by elementary and secondary schools has arisen out of a growing recognition that schools alone are not prepared to address the myriad of health, education, and social service needs of a large number of students, particularly children living in poverty. Boys and girls entering classrooms hungry, sick, homeless, or otherwise distracted are not ready to learn. Improving readiness to learn is a major agenda among educators. Case management is one approach many schools are beginning to use to collaboratively engage parents, community service agencies, the private sector, and communities at large in pursuit of the goal...
1997: Journal of Case Management
A Wada, T Hirayama, H Kitaura, J Fujisawa, M Hasegawa, Y Hidaka, Y Shimonishi
Guanylyl cyclase C (STaR), a receptor protein for heat-stable enterotoxin (STa) elaborated by Escherichia coli, is associated with and spans the plasma membrane of mammalian intestinal cells. The extracellular domain functions in the binding of STa and the association of each domain to an oligomeric form. Two amino acid residues, Arg-136 and Asp-347, were identified as the residues binding to STa in the extracellular domain of pig STaR by site-directed mutagenesis and analysis of expression on 293T cells. Replacement of these residues by other amino acid residues resulted in the loss of binding of pig STaR to STa, and as a result, STa-induced guanylyl cyclase activity was eliminated...
December 1996: Infection and Immunity
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