keyword
https://read.qxmd.com/read/37703066/a-descriptive-study-of%C3%A2-casualties-evacuated-out-of%C3%A2-afghanistan-by-critical-care-air-transport-teams-during-the-withdrawal-of%C3%A2-u-s-troops
#1
JOURNAL ARTICLE
Darren Baldwin, Allyson A Arana, Shelia C Savell, Julie Cutright, Kim Medellin, Maria Castaneda, Vikhyat S Bebarta, William T Davis, Joseph K Maddry, Patrick C Ng
INTRODUCTION: The War in Afghanistan ended in August 2021. Evacuation from the country was a large effort during the last days of the conflict. During evacuation efforts at Kabul Hamid Karzai International Airport, a suicide bombing occurred necessitating emergent medical care for many injured troops and civilians. The U.S. Air Force Critical Care Air Transport Teams (CCATTs) played a role in the medical care provided during the operations in Afghanistan. We report on in-flight events and interventions that took place during the final days of the Afghanistan withdrawal...
September 13, 2023: Military Medicine
https://read.qxmd.com/read/36323192/pheophorbide-a-isolated-from-gelidium-amansii-inhibits-adipogenesis-by-regulating-adipogenic-transcription-factors-and-ampk-in-3t3-l1-adipocytes
#2
JOURNAL ARTICLE
Mi Hwa Park, Hak-Ju Kim, Ji-Sook Han
Adipocyte lipid accumulation causes adipocyte hypertrophy and adipose tissue increment, leading to obesity. As part of our efforts to isolate antiobesity agents from natural products, we first isolated the active compound from the extract of Gelidium amansii through bioassay-guided fractionation. We then hypothesized that pheophorbide A isolated from G amansii inhibits adipogenesis by downregulating adipogenic transcription factors; therefore, the antiadipogenic effects of pheophorbide A were investigated in 3T3-L1 adipocytes...
October 7, 2022: Nutrition Research
https://read.qxmd.com/read/36165680/a-retrospective-cohort-study-of-burn-casualties-transported-by-the-us-army-burn-flight-team-and-us-air-force-critical-care-air-transport-teams
#3
JOURNAL ARTICLE
Shelia C Savell, Jeff T Howard, Christopher A VanFosson, Kimberly L Medellín, Amanda M Staudt, Julie A Rizzo, Joseph K Maddry, Leopoldo C Cancio
INTRODUCTION: The US Army Burn Center, the only burn center in the Department of Defense provides comprehensive burn care. The Burn Flight Team (BFT) provides specialized burn care during transcontinental evacuation. During Operations Iraqi and Enduring Freedom, burn injuries accounted for approximately 5% of all injuries in military personnel. To augment BFT capacity, US Air Force Critical Care Air Transport Teams (CCATTs) mobilized to transport burn patients. The purpose of this study was to describe critically ill, burn injured patients transported to the US Army Burn Center by BFT or CCATT, to compare and contrast characteristics, evacuation procedures, in-flight treatments, patient injuries/illnesses, and outcomes between the two groups...
September 27, 2022: Military Medicine
https://read.qxmd.com/read/35921899/protein-arginine-methyltransferase-prmt1-promotes-adipogenesis-by-modulating-transcription-factors-c-ebp%C3%AE-and-ppar%C3%AE
#4
JOURNAL ARTICLE
Qi Zhu, Dinghui Wang, Feng Liang, Xian Tong, Ziyun Liang, Xiaoyu Wang, Yaosheng Chen, Delin Mo
Protein arginine methyltransferase 1 (PRMT1) methylates a variety of histone and non-histone protein substrates to regulate multiple cellular functions such as transcription, DNA damage response, and signal transduction. It has been reported as an emerging regulator of various metabolic pathways including glucose metabolism in the liver, atrophy in the skeletal muscle, and lipid catabolism in the adipose tissue. However, the underlying mechanisms governing how PRMT1 regulates adipogenesis remain elusive. Here, we delineate the roles of PRMT1 in mitotic clonal expansion (MCE) and adipocyte differentiation...
July 31, 2022: Journal of Biological Chemistry
https://read.qxmd.com/read/35639920/relevance-of-deployment-experience-and-clinical-practice-characteristics-on-military-critical-care-air-transport-team-readiness-a-study-of-simulation-construct-validity
#5
JOURNAL ARTICLE
Daniel J Brown, Lane Frasier, F Eric Robinson, Mark Cheney, William T Davis, Ann Salvator, Mark Andresen, Melissa Proctor, Ryan Earnest, Timothy Pritts, Richard Strilka
INTRODUCTION: The Critical Care Air Transport Team (CCATT) Advanced course utilizes fully immersive high-fidelity simulations to train CCATT personnel and assess their readiness for deployment. This study aims to (1) determine whether these simulations correctly discriminate between students with previous deployment experience ("experienced") and no deployment experience ("novices") and (2) examine the effects of students' clinical practice environment on their performance during training simulations...
May 27, 2022: Military Medicine
https://read.qxmd.com/read/35444151/hemodynamic-events-during-en-route-critical-care-for-patients-with-traumatic-brain-injury
#6
JOURNAL ARTICLE
William T Davis, Kimberly L Medellin, Julie E Cutright, Allyson A Arana, Richard Strilka, Derek Sorensen, Joseph K Maddry, Shelia C Savell, Patrick C Ng
BACKGROUND: Exposure to stressors of flight may increase risk of secondary insults among critically injured combat casualties wounded with traumatic brain injury (TBI). The primary objective of this study was to describe the prevalence of hemodynamic events by phase of transport among patients with TBI transported by Critical Care Air Transport Teams (CCATT). METHODS: We performed a secondary analysis of a retrospective cohort of 477 adults with moderate to severe TBI, who required transport by CCATT to Germany from multiple hospitals in the Middle East between January 2007 and May 2014...
August 1, 2022: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/34986265/evacuation-strategies-for-u-s-casualties-with-traumatic-brain-injury-tbi-with-and-without-polytrauma
#7
JOURNAL ARTICLE
Patrick C Ng, Allyson A Araña, Shelia C Savell, William T Davis, Julie Cutright, Crystal A Perez, Vikhyat S Bebarta, Joseph K Maddry
INTRODUCTION: According to the Military Health System Traumatic Brain Injury (TBI) Center of Excellence, 51,261 service members suffered moderate to severe TBI in the last 21 years. Moderate to severe TBI in service members is usually related to blast injury in combat operations, which necessitates medical evacuation to higher levels of care. Prevention of secondary insult, and mitigation of the unique challenges associated with the transport of TBI patients in a combat setting are important in reducing the morbidity and mortality associated with this injury...
January 5, 2022: Military Medicine
https://read.qxmd.com/read/34865107/improved-adherence-to-best-practice-ventilation-management-after-implementation-of-clinical-practice-guideline-cpg-for-united-states-military-critical-care-air-transport-teams-ccatts
#8
JOURNAL ARTICLE
Joseph K Maddry, Alejandra G Mora, Crystal A Perez, Allyson A Arana, Kimberly L Medellin, Joni A Paciocco, Patrick C Ng, William T Davis, John C Hunninghake, Vikhyat S Bebarta
BACKGROUND: Critical Care Air Transport Teams (CCATTs) play a vital role in the transport and care of critically ill and injured patients in the combat theater to include mechanically ventilated patients. Previous research has demonstrated improved morbidity and mortality when lung protective ventilation strategies are used. Our previous study of CCATT trauma patients demonstrated frequent non-adherence to the Acute Respiratory Distress Syndrome Network (ARDSNet) protocol and a corresponding association with increased mortality...
December 4, 2021: Military Medicine
https://read.qxmd.com/read/34755847/development-of-a-critical-care-air-transport-team-go-bag-slimming-down-icu-capability-to-augment-pararescue-or-civilian-contract-medical-evacuation-personnel
#9
JOURNAL ARTICLE
Craig D Nowadly, Kyle E Foley, Maxwell L Davis, Erik J Hebert, Gabe A Corey
INTRODUCTION: Critical Care Air Transport Team (CCATT) is a three-person United States Air Force (USAF) medical asset, typically providing intercontinental medical evacuation on large military aircraft. The CCATT equipment Allowance Standard (AS) weighs approximately 272 kg (600 lbs). In austere locations, CCATT teams may augment contract medical evacuation (CME) personnel or Pararescue (PJ) in small aircraft with limited space for medical equipment. It was unknown what deployed PJ and CME carry within their packouts...
November 10, 2021: Military Medicine
https://read.qxmd.com/read/34594066/scoring-system-for-activation-of-critical-care-air-transport-team-for-aeromedical-evacuation
#10
JOURNAL ARTICLE
Manish Dhawan, M C Joshi, Puja Dudeja
BACKGROUND: Our hospital began work on formulating its own critical care air transport team (CCATT) and patient transfer unit (PTU) in 2007. A total of 293 patients have been evacuated by air using the various models of the PTU from April 2008 to February 2017. This study has been undertaken to formulate a protocol for activation of CCATT for aeromedical evacuation that best suits our setup keeping in view the availability of electromedical equipment, manpower and aircrafts. METHODS: The study is a cross-sectional study involving patients who were air evacuated between January 2010 to February 2017...
October 2021: Medical Journal, Armed Forces India
https://read.qxmd.com/read/33560385/antileukemic-efficacy-of-a-potent-artemisinin-combined-with-sorafenib-and-venetoclax
#11
JOURNAL ARTICLE
Blake S Moses, Samantha McCullough, Jennifer M Fox, Bryan T Mott, Søren M Bentzen, MinJung Kim, Jeffrey W Tyner, Rena G Lapidus, Ashkan Emadi, Michelle A Rudek, Tami J Kingsbury, Curt I Civin
Artemisinins are active against human leukemia cell lines and have low clinical toxicity in worldwide use as antimalarials. Because multiagent combination regimens are necessary to cure fully evolved leukemias, we sought to leverage our previous finding that artemisinin analogs synergize with kinase inhibitors, including sorafenib (SOR), by identifying additional synergistic antileukemic drugs with low toxicity. Screening of a targeted antineoplastic drug library revealed that B-cell lymphoma 2 (BCL2) inhibitors synergize with artemisinins, and validation assays confirmed that the selective BCL2 inhibitor, venetoclax (VEN), synergized with artemisinin analogs to inhibit growth and induce apoptotic cell death of multiple acute leukemia cell lines in vitro...
February 9, 2021: Blood Advances
https://read.qxmd.com/read/32491083/influence-of-air-pollutants-on-pneumonia-hospitalizations-among-children-in-a-town-in-the-brazilian-legal-amazon-region-a-time-series-study
#12
JOURNAL ARTICLE
Danila Pequeno Santana, Viviane Martins Santos, Ageo Mário Cândido da Silva, Walkiria Shimoya-Bittencourt
BACKGROUND: Exposure to particulate material produced as a result of increased agricultural activity may increase the number of pneumonia hospitalizations among children. We hope to contribute to the knowledge base through highlighting the environmental mechanisms involved in this outcome and optimizing pollutant control policies. OBJECTIVES: To investigate the association between pneumonia hospitalizations among children and presence of environmental pollutants in a town in the Brazilian Legal Amazon region...
March 2020: São Paulo Medical Journal
https://read.qxmd.com/read/31334769/influence-of-time-to-transport-to-a-higher-level-facility-on-the-clinical-outcomes-of-us-combat-casualties-with-tbi-a-multicenter-7-year-study
#13
JOURNAL ARTICLE
Joseph K Maddry, Allyson A Arana, Crystal A Perez, Kimberly L Medellin, Joni A Paciocco, Alejandra G Mora, William G Holder, William T Davis, Paco S Herson, Vikhyat S Bebarta
INTRODUCTION: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is associated with mortality rates as high as 30%. Patients with TBI are at high risk for secondary injury and need to be transported to definitive care expeditiously. However, the physiologic effects of aeromedical evacuation are not well understood and may compound these risks. Combat TBI patients may benefit from delayed aeromedical evacuation. The goal of this study was to evaluate the impact of transport timing out of theater via Critical Care Air Transport Teams (CCATT) to a higher level facility on the clinical outcomes of combat casualties with TBI...
February 13, 2020: Military Medicine
https://read.qxmd.com/read/30811531/descriptive-analysis-of-cardiac-patients-transported-by-critical-care-air-transport-teams
#14
JOURNAL ARTICLE
Shelia C Savell, Allyson A Arana, Kimberly L Medellin, Vikhyat S Bebarta, Crystal A Perez, Lauren K Reeves, Alejandra G Mora, Joseph K Maddry
INTRODUCTION: Critical Care Air Transport Teams (CCATTs) transport critically ill patients within and out of theaters of combat operations. Studies of the CCATT population reveal as many as 35% of patients have a non-trauma diagnosis, of which more than half are cardiac.The purpose of this retrospective study was to describe the epidemiology of critically ill patients with cardiac diagnoses evacuated from theater via CCATT. MATERIALS AND METHODS: We conducted a retrospective review of 290 medical patients with a primary cardiac diagnosis transported from any theater of operation to Landstuhl Regional Medical Center, Germany from January 2007 to April 2015...
July 1, 2019: Military Medicine
https://read.qxmd.com/read/30535030/en-route-resuscitation-utilization-of-ccatt-to-transport-and-stabilize-critically-injured-and-unstable-casualties
#15
JOURNAL ARTICLE
Joseph K Maddry, Eric M Ball, Daniel B Cox, Kathleen M Flarity, Vikhyat S Bebarta
Introduction: The U.S. Air Force utilizes specialized Critical Care Air Transport Teams (CCATT) for transporting "stabilized" patients. Given the drawdown of military forces from various areas of operation, recent CCATT operations have increasingly involved the evacuation of unstable and incompletely resuscitated patients from far forward, austere locations. This brief report describes unique cases representative of the evolving CCATT mission and provides future direction for changes in doctrine and educational requirements in preparation for en route combat casualty care...
December 7, 2018: Military Medicine
https://read.qxmd.com/read/29416602/the-prognostic-significance-of-nuclear-expression-of-phf2-and-c-ebp%C3%AE-in-clear-cell-renal-cell-carcinoma-with-consideration-of-adipogenic-metabolic-evolution
#16
JOURNAL ARTICLE
Jeong Hwan Park, Minsun Jung, Kyung Chul Moon
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cell carcinoma (RCC), and it has an unfavourable prognosis compared to other RCCs. Plant homeodomain finger 2 (PHF2) and CCATT/enhancer binding protein α (C/EBPα) play a role in the epigenetic regulation of adipogenesis, and their tumour suppressive functions have been elucidated. This study aimed to assess the nuclear expression of PHF2 and C/EBPα in ccRCC and to evaluate their role in pathogenesis and prognosis. The nuclear expression of PHF2 and C/EBPα was evaluated in 344 cases of ccRCC by immunohistochemistry, and adipogenesis was assessed based on cytoplasmic features...
January 2, 2018: Oncotarget
https://read.qxmd.com/read/29327725/whole-genome-sequencing-reveals-principles-of-brain-retrotransposition-in-neurodevelopmental-disorders
#17
JOURNAL ARTICLE
Jasmine Jacob-Hirsch, Eran Eyal, Binyamin A Knisbacher, Jonathan Roth, Karen Cesarkas, Chen Dor, Sarit Farage-Barhom, Vered Kunik, Amos J Simon, Moran Gal, Michal Yalon, Sharon Moshitch-Moshkovitz, Rick Tearle, Shlomi Constantini, Erez Y Levanon, Ninette Amariglio, Gideon Rechavi
Neural progenitor cells undergo somatic retrotransposition events, mainly involving L1 elements, which can be potentially deleterious. Here, we analyze the whole genomes of 20 brain samples and 80 non-brain samples, and characterized the retrotransposition landscape of patients affected by a variety of neurodevelopmental disorders including Rett syndrome, tuberous sclerosis, ataxia-telangiectasia and autism. We report that the number of retrotranspositions in brain tissues is higher than that observed in non-brain samples and even higher in pathologic vs normal brains...
February 2018: Cell Research
https://read.qxmd.com/read/28882451/development-and-mechanism-of-small-activating-rna-targeting-cebpa-a-novel-therapeutic-in-clinical-trials-for-liver-cancer
#18
JOURNAL ARTICLE
Jon Voutila, Vikash Reebye, Thomas C Roberts, Pantelitsa Protopapa, Pinelopi Andrikakou, David C Blakey, Robert Habib, Hans Huber, Pal Saetrom, John J Rossi, Nagy A Habib
Small activating RNAs (saRNAs) are short double-stranded oligonucleotides that selectively increase gene transcription. Here, we describe the development of an saRNA that upregulates the transcription factor CCATT/enhancer binding protein alpha (CEBPA), investigate its mode of action, and describe its development into a clinical candidate. A bioinformatically directed nucleotide walk around the CEBPA gene identified an saRNA sequence that upregulates CEBPA mRNA 2.5-fold in human hepatocellular carcinoma cells...
December 6, 2017: Molecular Therapy
https://read.qxmd.com/read/28570350/impact-of-critical-care-air-transport-team-ccatt-ventilator-management-on-combat-mortality
#19
JOURNAL ARTICLE
Joseph K Maddry, Alejandra G Mora, Shelia C Savell, Crystal A Perez, Phillip E Mason, James K Aden, Vikhyat S Bebarta
BACKGROUND: Aeromedical evacuation platforms such as Critical Care Air Transport Teams (CCATTs) play a vital role in the transport and care of critically injured and ill patients in the combat theater. Mechanical ventilation is used to support patients with failing respiratory function and patients requiring high levels of sedation. Mechanical ventilation, if not managed appropriately, can worsen or cause lung injury and contribute to increased morbidity. The purpose of this study was to evaluate the impact of ARDSNet protocol compliance during aeromedical evacuation of ventilated combat injured patients...
January 2018: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/28385926/critical-care-air-transport-team-severe-traumatic-brain-injury-short-term-outcomes-during-flight-for-operation-iraqi-freedom-operation-enduring-freedom
#20
JOURNAL ARTICLE
L Renee Boyd, J Borawski, J Lairet, A T Limkakeng
INTRODUCTION: Our understanding of the expertise and equipment required to air transport injured soldiers with severe traumatic brain injuries (TBIs) continue to evolve. METHODS: We conducted a retrospective chart review of characteristics, interventions required and short-term outcomes of patients with severe TBI managed by the US Air Force Critical Care Air Transport Teams (CCATTs) deployed in support of Operation Iraqi Freedom and Operation Enduring Freedom between 1 June 2007 and 31 August 2010...
October 2017: Journal of the Royal Army Medical Corps
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