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https://www.readbyqxmd.com/read/29452056/promoting-addiction-medicine-teaching-through-functional-mentoring-by-co-training-generalist-chief-residents-with-faculty-mentors
#1
Daniel P Alford, Brittany L Carney, Angela H Jackson, Belle Brett, Carly Bridden, Michael Winter, Jeffrey H Samet
BACKGROUND: Generalist physicians should play a vital role in identifying and managing individuals with substance use but are inadequately trained to do so. METHODS: This 5 year (2008-2012) controlled educational study assessed whether internal medicine and family medicine chief residents' (CRs) addiction medicine teaching increased by co-training with faculty mentors at a Chief Resident Immersion Training (CRIT) program in addiction medicine. All CRIT CR attendees identified a residency program faculty mentor to support addiction medicine teaching after CRIT through functional mentoring with a focus on developing and implementing an Addiction Medicine Teaching Project ("Teaching Project")...
February 16, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29447356/barriers-to-the-availability-and-accessibility-of-controlled-medicines-for-chronic-pain-in-africa
#2
Elmang Nchako, Scottie Bussell, Carlos Nesbeth, Chisom Odoh
Africans endure a high burden of pain and suffering from HIV/AIDS and cancer, yet receive a meager amount of the world's pain medication. This tragedy occurs needlessly, given that inexpensive, effective and easily administered interventions are available. WHO has a 'three-step analgesic ladder' framework for managing cancer pain. This widely adopted clinical practice guideline is an integral part of palliative care programs and has also been applied to non-cancer pain. However, untreated pain is a major public health problem due to the discordance between scientific evidence and public policy...
February 13, 2018: International Health
https://www.readbyqxmd.com/read/29445521/a-method-for-co-creation-of-an-evidence-based-patient-workbook-to-address-alcohol-use-when-quitting-smoking-in-primary-care-a-case-study
#3
Nadia Minian, Aliya Noormohamed, Laurie Zawertailo, Dolly Baliunas, Norman Giesbrecht, Bernard Le Foll, Jürgen Rehm, Andriy Samokhvalov, Peter L Selby
Plain English summary: The purpose of this paper is to describe a patient engagement event designed to create an educational workbook with smokers who drink alcohol at harmful levels. The goal was to create a workbook that combined scientific evidence with patients' values, preferences, and needs. Fourteen adult smokers who drink alcohol were invited to the Centre for Addiction and Mental Health (CAMH) to take part in a four-hour event to help design the workbook with the CAMH research team...
2018: Research involvement and engagement
https://www.readbyqxmd.com/read/29440815/aspiring-pain-practitioners-in-india-assessing-challenges-and-building-opportunities
#4
Sushma Bhatnagar, Anuradha Patel, Srinivasa N Raja
Background: Pain medicine is a developing specialty, aimed at relieving pain and suffering, enhancing function, and improving the quality of life of patients. Pain is often ignored, under-reported and mismanaged by health-care providers. Aspiring pain physicians in India face many challenges and barriers in advancing their specialty. Objectives: The objective of this study is to determine the challenges in establishing a pain practice in India and to discuss the opportunities and strategies to overcome these barriers...
January 2018: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/29439945/work-addiction-test-questionnaire-to-assess-workaholism-validation-of-french-version
#5
Hortense Ravoux, Bruno Pereira, Georges Brousse, Samuel Dewavrin, Thomas Cornet, Martial Mermillod, Laurie Mondillon, Guillaume Vallet, Farès Moustafa, Frédéric Dutheil
BACKGROUND: Work addiction is a significant public health problem with a growing prevalence. The Work Addiction Risk Test (WART) is the gold standard questionnaire to detect workaholism. OBJECTIVE: The main objective of this study was to validate the French version of the WART. METHODS: Questionnaires were proposed to voluntary French workers using the WittyFit software. There were no exclusion criteria. The questionnaire was administered anonymously for initial validity testing and readministered one week later for test-retest reliability...
February 13, 2018: JMIR Mental Health
https://www.readbyqxmd.com/read/29432074/an-opioid-overdose-curriculum-for-medical-residents-impact-on-naloxone-prescribing-knowledge-and-attitudes
#6
Jessica Lee Taylor, Alison B Rapoport, Christopher F Rowley, Kenneth J Mukamal, Wendy Stead
BACKGROUND: Despite escalating opioid overdose death rates, addiction medicine is underrepresented in residency curricula. Providing naloxone to at-risk patients, relatives, and first responders reduces overdose deaths, but rates of naloxone prescribing remain low. The goal of this study is to examine the impact of a brief curricular intervention for internal medicine residents on naloxone prescribing rates, knowledge, and attitudes. METHODS: Internal medicine residents (n = 160) at an urban, tertiary care medical center received two one-hour didactic sessions addressing overdose prevention, including intranasal naloxone...
February 12, 2018: Substance Abuse
https://www.readbyqxmd.com/read/29431696/e-cigarette-report-reveals-research-gaps
#7
(no author information available yet)
In a comprehensive analysis of existing studies, the U.S. National Academies of Sciences, Engineering, and Medicine concluded that electronic cigarettes are addictive, though less toxic than conventional cigarettes. The report also identified key areas for future research, including smoking cessation, adolescent use, and long-term health effects.
February 5, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29429049/implication-of-genes-for-the-n-methyl-d-aspartate-nmda-receptor-in-substance-addictions
#8
REVIEW
Jiali Chen, Yunlong Ma, Rongli Fan, Zhongli Yang, Ming D Li
Drug dependence is a chronic brain disease with harmful consequences for both individual users and society. Glutamate is a primary excitatory neurotransmitter in the brain, and both in vivo and in vitro experiments have implicated N-methyl-D-aspartate (NMDA) receptor, a glutamate receptor, as an element in various types of addiction. Recent findings from genetics-based approaches such as genome-wide linkage, candidate gene association, genome-wide association (GWA), and next-generation sequencing have demonstrated the significant association of NMDA receptor subunit genes such as GluN3A, GluN2B, and GluN2A with various addiction-related phenotypes...
February 10, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29423824/attitudes-of-irish-patients-with-chronic-pain-towards-medicinal-cannabis
#9
Ciaran Rochford, Deirdre Edgeworth, Mohammad Hashim, Dominic Harmon
BACKGROUND: Medicinal cannabis use is topical in the media in Ireland. A recent Health Products Regulatory Authority review, however, has recommended against its use for patients with chronic pain. This is despite evidence for its effectiveness in this patient's cohort and the inadequate pain management of these patients. AIM: The aim of this study was to evaluate the attitudes of Irish patients with chronic pain towards medicinal cannabis. METHODS: After institutional ethics committee approval, a 12-item questionnaire (excluding demographics) was randomly assigned to patients attending a chronic pain clinic (University Hospital Limerick)...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29413524/mu-opioid-pharmacology-40-years-to-the-promised-land
#10
Gavril W Pasternak
Opioids continue to play a major role in medicine, but not without problems. Side effects limit their utility medically, while the potential of addiction has had a major societal impact. Pharmacologists have been trying to develop opioids lacking side effects since the first derivative, heroin, was synthesized in the 1870s. The identification of opioid receptors about 40 years ago opened up new insights into our understanding of opioid action, fueled by the molecular biology revolution of the 1980s and 1990s...
2018: Advances in Pharmacology
https://www.readbyqxmd.com/read/29413373/physicians-addicted-to-prescribing-aspirin-a-disorder-of-cardiologists-papa-doc-syndrome-the-headache-of-nonevidence-based-medicine-for-ischemic-heart-disease
#11
EDITORIAL
https://www.readbyqxmd.com/read/29408011/bh3-mimetics-as-antifibrotic-therapy-unleashing-the-mitochondrial-pathway-of-apoptosis-in-myofibroblasts
#12
REVIEW
Tobias Kuehl, David Lagares
Organs and tissues in mammals can undergo self-repair following injury. However, chronic or severe tissue injury leads to the development of dense scar tissue or fibrosis at the expense of regeneration. The identification of novel therapeutic strategies aiming at reversing fibrosis is therefore a major clinical unmet need in regenerative medicine. Persistent activation of scar-forming myofibroblasts distinguishes non-resolving pathological fibrosis from self-limited physiological wound healing. Thus, therapeutic strategies selectively inducing myofibroblast apoptosis could prevent progression and potentially reverse established fibrosis in fibrotic diseases...
January 30, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29406920/alcohol-use-and-hospital-readmissions-following-stroke-a-safety-net-hospital-experience
#13
Simy Parikh, Paul George, Kevin Wilson, Denis Rybin, Anna DePold Hohler
OBJECTIVE: The purpose of this study is to identify predictors of stroke-related readmissions at 30days on a safety net hospital level and suggest interventions to reduce the number of readmissions. BACKGROUND: Hospital readmissions are an important measure of the quality of health care services. Readmissions indicate unresolved problems from the index admission, inadequate post-hospitalization care, or a mixture of these factors. Additionally, hospital readmissions are associated with a substantial economic burden on the health care system...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29366418/ayahuasca-psychological-and-physiologic-effects-pharmacology-and-potential-uses-in-addiction-and-mental-illness
#14
Jonathan Hamill, Jaime Hallak, Serdar M Dursun, Glen Baker
Ayahuasca, a traditional Amazonian decoction with psychoactive properties, is made from bark of the Banisteriopsis caapi vine (contains beta-carboline alkaloids) and leaves of the Psychotria viridis bush (supply the hallucinogen N,N-dimethyltryptamine (DMT)). Originally used by indigenous shamans for the purposes of spirit communication, magical experiences, healing, and religious rituals, across several South American countries ayahuasca has been incorporated into folk medicine and spiritual healing, and several Brazilian churches use it routinely to foster spiritual experience...
January 24, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29344267/break-breast-cancer-addiction-by-crispr-cas9-genome-editing
#15
REVIEW
Haitao Yang, MariaLynn Jaeger, Averi Walker, Daniel Wei, Katie Leiker, Tao Weitao
Breast cancer is the leading diagnosed cancer for women globally. Evolution of breast cancer in tumorigenesis, metastasis and treatment resistance appears to be driven by the aberrant gene expression and protein degradation encoded by the cancer genomes. The uncontrolled cancer growth relies on these cellular events, thus constituting the cancerous programs and rendering the addiction towards them. These programs are likely the potential anticancer biomarkers for Personalized Medicine of breast cancer. This review intends to delineate the impact of the CRSPR/Cas-mediated genome editing in identification and validation of these anticancer biomarkers...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29324253/a-qualitative-study-comparing-physician-reported-barriers-to-treating-addiction-using-buprenorphine-and-extended-release-naltrexone-in-u-s-office-based-practices
#16
Barbara Andraka-Christou, Matthew J Capone
AIM: Our aim was to compare physician-reported barriers to sublingual buprenorphine (BUP) and extended-release naltrexone (XR-NLT) prescribing in U.S. office-based practices, and to identify potential policies for minimizing these barriers. Only one previous qualitative study has examined physician-reported barriers to prescribing XR-NLT and no qualitative study has compared physician-reported barriers between the two medications. METHODS: Researchers conducted individual semi-structured and in-depth interviews with 20 licensed physicians in four U...
January 8, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29311535/the-medicinal-usage-and-restriction-of-ginseng-in-britain-and-america-1660-1900
#17
Heasim Sul
This article demonstrates the medicinal usage of ginseng in the West from 1660 to 1914. Asian[Korea] ginseng was first introduced into England in the early 17th century, and North American ginseng was found in the early 18th century. Starting from the late 17th century doctors prescribed ginseng to cure many different kinds of ailments and disease such as: fatigue general lethargy, fever, torpidity, trembling in the joints, nervous disorder, laughing and crying hysteria, scurvy, spermatic vessel infection, jaundice, leprosy, dry gripes and constipation, strangury, yellow fever, dysentery, infertility and addictions of alcohol, opium and tobacco, etc...
December 2017: Ŭi Sahak
https://www.readbyqxmd.com/read/29309862/escalation-of-liver-malfunctioning-a-step-toward-herbal-awareness
#18
REVIEW
Bushra Sultana, Sadaf Yaqoob, Zohaib Zafar, Haq Nawaz Bhatti
ETHNOPHARMACOLOGICAL RELEVANCE: About 2 to 5 % of the world's population is suffering from liver toxicity including Pakistan with the second highest rate of hepatitis prevalence. Liver is a vital body organ which not only performs metabolic activities but also aids in detoxification, storage and digestion of food. Now a day's malnutrition, alcohol consumption and drug addiction are major causes of liver diseases throughout the world. In fact, there is no possible outcome to compensate liver malfunction for long term, and transplantation of liver is the only option left after the irretrievable injury of hepatic function...
January 5, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29283486/toward-precision-medicine-in-addiction-treatment
#19
Nora Volkow
No abstract text is available yet for this article.
January 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29248905/primary-addictive-substances-used-among-patients-treated-in-a-hospital-based-addiction-medicine-service
#20
Daniel Feingold, Shaul Lev-Ran
INTRODUCTION: This study sought to explore the differences in primary addictive substances used among individuals referred to an ambulatory hospital-based addiction service in Israel according to sex, age and source of referral. METHOD: Data were drawn from all referral forms received during a two-year period (N=140). Categories of primary addictive substances included alcohol, drugs (cannabis, synthetic cannabinoids, illicit stimulants and heroin) and medications (prescription opioids, prescription stimulants and benzodiazepines)...
2017: Israel Journal of Psychiatry and related Sciences
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