keyword
https://read.qxmd.com/read/38445706/health-related-quality-of-life-and-dna-methylation-based-aging-biomarkers-among-survivors-of-childhood-cancer
#1
JOURNAL ARTICLE
Noel-Marie Plonski, Yue Pan, Cheng Chen, Qian Dong, Xijun Zhang, Nan Song, Kyla Shelton, John Easton, Heather Mulder, Jinghui Zhang, Geoffrey Neale, Emily Walker, Hui Wang, Rachel Webster, Tara Brinkman, Kevin R Krull, Gregory T Armstrong, Kirsten K Ness, Melissa M Hudson, Qian Li, I-Chan Huang, Zhaoming Wang
BACKGROUND: Childhood cancer survivors are at high risk for morbidity and mortality and poor patient-reported outcomes, typically health-related-quality-of-life (HRQOL). However, associations between DNA methylation (DNAm)-based aging biomarkers and HRQOL have not been evaluated. METHODS: DNAm was generated with Infinium EPIC BeadChip on blood-derived DNA (median[range] for age at blood draw = 34.5[18.5-66.6] years) and HRQOL was assessed with age at survey (32...
March 5, 2024: Journal of the National Cancer Institute
https://read.qxmd.com/read/38444450/anatomically-based-ablation-of-left-ventricular-summit-premature-ventricular-complexes-guided-by-intracardiac-echocardiography
#2
JOURNAL ARTICLE
Nikhil Sharma, Kristie M Coleman, Gregory Cunn, Jeremy Kleiman, Stavros E Mountantonakis
Catheter ablation of premature ventricular contractions (PVCs) arising from the left ventricular summit (LVS) presents technical challenges due to the regional anatomy and frequent intramural site of origin (SOO). Intracardiac echocardiography (ICE) and the CARTOSOUND® (Biosense Webster, Diamond Bar, CA, USA) module allow the operator to directly reconstruct and visualize the dimensions and orientation of the LVS live and present it in relation to neighboring structures. We retrospectively reviewed consecutive cases between January 2021 and December 2022 of patients undergoing PVC ablation for a presumed LVS origin...
February 2024: Journal of Innovations in Cardiac Rhythm Management
https://read.qxmd.com/read/38229148/the-impact-of-damaging-epilepsy-and-cardiac-genetic-variant-burden-in-sudden-death-in-the-young
#3
JOURNAL ARTICLE
Megan J Puckelwartz, Lorenzo L Pesce, Edgar J Hernandez, Gregory Webster, Lisa M Dellefave-Castillo, Mark W Russell, Sarah S Geisler, Samuel D Kearns, Felix Karthik, Susan P Etheridge, Tanner O Monroe, Tess D Pottinger, Prince J Kannankeril, M Benjamin Shoemaker, Darlene Fountain, Dan M Roden, Meghan Faulkner, Heather M MacLeod, Kristin M Burns, Mark Yandell, Martin Tristani-Firouzi, Alfred L George, Elizabeth M McNally
BACKGROUND: Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characterize genetic variation in an SDY cohort using whole genome sequencing. METHODS: The SDY Case Registry is a National Institutes of Health/Centers for Disease Control and Prevention surveillance effort to discern the prevalence, causes, and risk factors for SDY...
January 16, 2024: Genome Medicine
https://read.qxmd.com/read/38219955/scmr-expert-consensus-statement-for-cardiovascular-magnetic-resonance-of-patients-with-a-cardiac-implantable-electronic-device
#4
JOURNAL ARTICLE
Daniel Kim, Jeremy D Collins, James A White, Kate Hanneman, Daniel C Lee, Amit R Patel, Peng Hu, Harold Litt, Jonathan W Weinsaft, Rachel Davids, Kanae Mukai, Ming-Yen Ng, Julian A Luetkens, Ariel Roguin, Carlos E Rochitte, Pamela K Woodard, Charlotte Manisty, Karolina M Zareba, Lluis Mont, Frank Bogun, Daniel B Ennis, Saman Nazarian, Gregory Webster, Jadranka Stojanovska
Cardiovascular magnetic resonance (CMR) is a proven imaging modality for informing diagnosis and prognosis, guiding therapeutic decisions, and risk stratifying surgical intervention. Patients with a cardiac implantable electronic device (CIED) would be expected to derive particular benefit from CMR given high prevalence of cardiomyopathy and arrhythmia. While several guidelines have been published over the last 16 years, it is important to recognize that both the CIED and CMR technologies, as well as our knowledge in MR safety, have evolved rapidly during that period...
January 12, 2024: Journal of Cardiovascular Magnetic Resonance
https://read.qxmd.com/read/38211978/treatment-of-idiopathic-pulmonary-fibrosis-and-progressive-pulmonary-fibrosis-a-position-statement-from-the-thoracic-society-of-australia-and-new-zealand-2023-revision
#5
JOURNAL ARTICLE
John A Mackintosh, Gregory Keir, Lauren K Troy, Anne E Holland, Christopher Grainge, Daniel C Chambers, Debra Sandford, Helen E Jo, Ian Glaspole, Margaret Wilsher, Nicole S L Goh, Paul N Reynolds, Sally Chapman, Steven E Mutsaers, Sally de Boer, Susanne Webster, Yuben Moodley, Tamera J Corte
Idiopathic pulmonary fibrosis (IPF) is a progressive disease leading to significant morbidity and mortality. In 2017 the Thoracic Society of Australia and New Zealand (TSANZ) and Lung Foundation Australia (LFA) published a position statement on the treatment of IPF. Since that time, subsidized anti-fibrotic therapy in the form of pirfenidone and nintedanib is now available in both Australia and New Zealand. More recently, evidence has been published in support of nintedanib for non-IPF progressive pulmonary fibrosis (PPF)...
February 2024: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://read.qxmd.com/read/38082570/rf-induced-heating-of-capped-and-uncapped-abandoned-epicardial-leads-during-mri-at-1-5-t-and-3-t
#6
JOURNAL ARTICLE
Fuchang Jiang, Kaylee R Henry, Bhumi Bhusal, Gregory Webster, Giorgio Bonmassar, Daniel Kim, Laleh Golestanirad
There is a paucity of data regarding the safety of magnetic resonance imaging (MRI) in patients with abandoned epicardial leads. Few studies have reported temperature rises up to 76 °C during MRI at 1.5 T in gel phantoms implanted with epicardial leads; however, lead trajectories used in these experiments were not clinically relevant. This work reports patient-specific RF heating of both capped and uncapped abandoned epicardial lead configurations during MRI at both 1.5 T and 3 T field strengths. We found that leads routed along realistic, patient-derived trajectories generated substantially lower RF heating than the previously reported worst-case phantom experiments...
July 2023: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://read.qxmd.com/read/37865522/prediction-of-sudden-death-risk-in-patients-with-congenital-heart-diseases
#7
REVIEW
Rohan Kumthekar, Gregory Webster
Risk stratification for sudden death should be discussed with patients with congenital heart disease at each stage of personal and cardiac development. For most patients, risk is low through teenage years and the critical factors to consider are anatomy, ventricular function, and symptoms. By adulthood, these are supplemented by screening for atrial arrhythmias, ventricular arrhythmias, and pulmonary hypertension. Therapies include medication, ablation, and defibrillator placement.
December 2023: Cardiac Electrophysiology Clinics
https://read.qxmd.com/read/37824255/intergenerational-patterns-of-attachment-in-custodial-grandfamilies
#8
JOURNAL ARTICLE
Austin J Blake, Frank J Infurna, Saul A Castro, Britney A Webster, Megan L Dolbin-MacNab, Gregory C Smith, D Max Crowley, Carol Musil
The present study aimed to identify intergenerational patterns of attachment insecurity among grandmothers, adolescent grandchildren, and birth mothers in custodial grandfamilies and to test the relations among triadic attachment patterns and grandchild socioemotional outcomes. Prior research with custodial grandfamilies has found distinct "profiles" reflecting patterns of closeness between grandmothers, grandchildren, and birth mothers. However, no studies have tested patterns of attachment insecurity among members of the triad, despite the likelihood of attachment disruption in grandfamilies...
October 12, 2023: Journal of Family Psychology: JFP
https://read.qxmd.com/read/37795813/anticancer-and-antibacterial-properties-of-carbon-nanotubes-are-governed-by-their-functional-groups
#9
JOURNAL ARTICLE
Aleksandra Benko, David Medina-Cruz, Sebastian Wilk, Magdalena Ziąbka, Barbara Zagrajczuk, Elżbieta Menaszek, Olga Barczyk-Woźnicka, Grégory Guisbiers, Thomas J Webster
Due to their high strength, low weight, and biologically-inspired dimensions, carbon nanotubes have found wide interest across all of medicine. In this study, four types of highly dispersible multi-walled carbon nanotubes (CNTs) of similar dimensions, but slightly different chemical compositions, were compared with an unmodified material to verify the impact their surface chemistry has on cytocompatibility, anticancer, inflammation, and antibacterial properties. Minute changes in the chemical composition were found to greatly affect the biological performance of the CNTs...
October 5, 2023: Nanoscale
https://read.qxmd.com/read/37773618/a-suicide-prevention-intervention-for-emerging-adult-sexual-and-gender-minority-groups-protocol-for-a-pilot-hybrid-effectiveness-randomized-controlled-trial
#10
JOURNAL ARTICLE
Lily A Brown, Jessica L Webster, Jennifer T Tran, James R Wolfe, Jesse Golinkoff, Esha Patel, Amanda C Arcomano, Jennifer Ben Nathan, Alexander Azat O'Connor, Yiqin Zhu, Maria Oquendo, Gregory K Brown, David Mandell, Danielle Mowery, José A Bauermeister
BACKGROUND: Suicide attempts and suicide death disproportionately affect sexual and gender minority emerging adults (age 18-24 years). However, suicide prevention strategies tailored for emerging adult sexual and gender minority (EA-SGM) groups are not widely available. The Safety Planning Intervention (SPI) has strong evidence for reducing the risk for suicide in the general population, but it is unclear how best to support EA-SGM groups in their use of a safety plan. Our intervention (Supporting Transitions to Adulthood and Reducing Suicide [STARS]) builds on content from an existing life skills mobile app for adolescent men who have sex with men (iREACH) and seeks to target core risk factors for suicide among EA-SGM groups, namely, positive affect, discrimination, and social disconnection...
September 29, 2023: JMIR Research Protocols
https://read.qxmd.com/read/37721007/daily-aggression-domains-differentially-relate-to-daily-affect-and-self-esteem
#11
JOURNAL ARTICLE
Gregory D Webster, John B Nezlek
How do daily fluctuations in aggression relate to daily variability in affect and self-esteem? Although research has examined how trait aggression relates to affect and self-esteem, state aggression has received little attention. To this end, we had 120 US undergraduates participate in a 14-day daily diary study where they responded to state-level measures of aggression, affect, and self-esteem. Crucially, we used multifaceted state measures of both aggression (anger, hostility, verbal aggression, physical aggression) and affect (positive vs...
September 18, 2023: Aggressive Behavior
https://read.qxmd.com/read/37685385/age-matters-a-comparative-study-of-rf-heating-of-epicardial-and-endocardial-electronic-devices-in-pediatric-and-adult-phantoms-during-cardiothoracic-mri
#12
JOURNAL ARTICLE
Fuchang Jiang, Kaylee R Henry, Bhumi Bhusal, Pia Sanpitak, Gregory Webster, Andrada Popescu, Christina Laternser, Daniel Kim, Laleh Golestanirad
This study focused on the potential risks of radiofrequency-induced heating of cardiac implantable electronic devices (CIEDs) in children and adults with epicardial and endocardial leads of varying lengths during cardiothoracic MRI scans. Infants and young children are the primary recipients of epicardial CIEDs, though the devices have not been approved as MR conditional by the FDA due to limited data, leading to pediatric hospitals either refusing the MRI service to most pediatric CIED patients or adopting a scan-all strategy based on results from adult studies...
September 2, 2023: Diagnostics
https://read.qxmd.com/read/37648183/multicenter-retrospective-evaluation-of-magnetic-resonance-imaging-in-pediatric-and-congenital-heart-disease-patients-with-cardiac-implantable-electronic-devices
#13
JOURNAL ARTICLE
Lindsey Gakenheimer-Smith, Zhining Ou, Jinqiu Kuang, Jeremy P Moore, Austin Burrows, Joshua Kovach, Brynn Dechert, Cheyenne M Beach, Mark Ayers, Reina Bianca Tan, Mina Mostafavifar, Douglas Y Mah, Tracy Marrs Conner, Susan Turpin, Kishor Avasarala, Maully J Shah, Gregory Webster, Jessica Posey, Susan P Etheridge, Edem Binka, Mary Niu, S Yukiko Asaki, Linda M Lambert, Thomas A Pilcher
BACKGROUND: Guidelines addressing magnetic resonance imaging (MRI) in patients with cardiac implantable electronic devices (CIEDs) provide algorithms for imaging pediatric and congenital heart disease (CHD) patients. Guideline acceptance varies by institution. Guidelines also do not support routine MRI scans in patients with epicardial or abandoned leads, common in pediatric and CHD patients. OBJECTIVE: The purpose of this study was to determine the incidence of MRI-related complications in pediatric and CHD patients with CIEDs, including epicardial and/or abandoned leads...
August 28, 2023: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/37545105/how-are-mental-representations-of-asthma-triggers-and-symptoms-related-to-interpersonal-risk-perceptions-a-psychometric-investigation-of-caregivers-of-children-with-asthma
#14
JOURNAL ARTICLE
Erika A Waters, Thorsten Pachur, Gabrielle Pogge, Jean Hunleth, Gregory D Webster, David A Fedele, James A Shepperd
OBJECTIVE: Parents and guardians (hereafter caregivers ) make decisions for their children's medical care. However, many caregivers of children with asthma struggle to understand their child's illness. We used the psychometric paradigm to investigate how caregivers conceptualize, or mentally represent , asthma triggers and symptoms and how these representations are linked to perceived asthma exacerbation risk. METHODS: We asked 377 caregivers of children with asthma across the U...
August 6, 2023: Psychology & Health
https://read.qxmd.com/read/37528649/clinical-presentation-of-calmodulin-mutations-the-international-calmodulinopathy-registry
#15
JOURNAL ARTICLE
Lia Crotti, Carla Spazzolini, Mette Nyegaard, Michael T Overgaard, Maria-Christina Kotta, Federica Dagradi, Luca Sala, Takeshi Aiba, Mark D Ayers, Anwar Baban, Julien Barc, Cheyenne M Beach, Elijah R Behr, J Martijn Bos, Marina Cerrone, Peter Covi, Bettina Cuneo, Isabelle Denjoy, Birgit Donner, Adrienne Elbert, Håkan Eliasson, Susan P Etheridge, Megumi Fukuyama, Francesca Girolami, Robert Hamilton, Minoru Horie, Maria Iascone, Juan Jiménez Jaimez, Henrik Kjærulf Jensen, Prince J Kannankeril, Juan P Kaski, Naomasa Makita, Carmen Muñoz-Esparza, Hans H Odland, Seiko Ohno, John Papagiannis, Alessandra Pia Porretta, Christopher Prandstetter, Vincent Probst, Tomas Robyns, Eric Rosenthal, Ferran Rosés-Noguer, Nicole Sekarski, Anoop Singh, Georgia Spentzou, Fridrike Stute, Jacob Tfelt-Hansen, Jan Till, Kathryn E Tobert, Jeffrey M Vinocur, Gregory Webster, Arthur A M Wilde, Cordula M Wolf, Michael J Ackerman, Peter J Schwartz
AIMS: Calmodulinopathy due to mutations in any of the three CALM genes (CALM1-3) causes life-threatening arrhythmia syndromes, especially in young individuals. The International Calmodulinopathy Registry (ICalmR) aims to define and link the increasing complexity of the clinical presentation to the underlying molecular mechanisms. METHODS AND RESULTS: The ICalmR is an international, collaborative, observational study, assembling and analysing clinical and genetic data on CALM-positive patients...
August 2, 2023: European Heart Journal
https://read.qxmd.com/read/37526134/modifying-the-trajectory-of-epicardial-leads-can-substantially-reduce-mri-induced-rf-heating-in-pediatric-patients-with-a-cardiac-implantable-electronic-device-at-1-5t
#16
JOURNAL ARTICLE
Fuchang Jiang, Bhumi Bhusal, Bach Nguyen, Michael Monge, Gregory Webster, Daniel Kim, Giorgio Bonmassar, Andrada R Popsecu, Laleh Golestanirad
PURPOSE: After epicardial cardiac implantable electronic devices are implanted in pediatric patients, they become ineligible to receive MRI exams due to an elevated risk of RF heating. We investigated whether simple modifications in the trajectories of epicardial leads could substantially and reliably reduce RF heating during MRI at 1.5 T, with benefits extending to abandoned leads. METHODS: Electromagnetic simulations were performed to assess RF heating of two common 35-cm epicardial lead trajectories exhibiting different degrees of coupling with MRI incident electric fields...
August 1, 2023: Magnetic Resonance in Medicine
https://read.qxmd.com/read/37473425/trans-2-3-enoyl-coa-reductase-like-related-catecholaminergic-polymorphic-ventricular-tachycardia-with-regular-ventricular-tachycardia-and-response-to-flecainide
#17
Mohammad A Ebrahim, Ali A Alkhabbaz, Buthaina Albash, Ali H AlSayegh, Gregory Webster
INTRODUCTION: We describe a unique case of TECRL-CPVT presented with cardiac arrest. METHODS: Post resuscitation, the patient developed regular ventricular tachycardia featuring a left purkinje system morphology. RESULTS: There was clear suppression of arrhythmia with the addition of flecainide and isolated ventricular ectopy causing secondary T-wave changes. CONCLUSION: A high index of suspicion was required to eventually make the diagnosis through whole exome sequencing...
September 2023: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/37363350/delay-discounting-for-hiv-sti-testing
#18
JOURNAL ARTICLE
Val Wongsomboon, Gregory D Webster
INTRODUCTION: Wait time in healthcare is an important barrier to HIV/STI testing. Using a delay discounting approach, the current study examined a systematic reduction in testing likelihood as a function of delay (wait time) until testing. METHODS: In Study 1 ( N = 421; data collected in 2019), participants were randomly assigned to either a chlamydia/gonorrhea group or HIV group. A delay discounting task asked them to report how likely they would get tested for the assigned STI if they had to wait for the test (the delay durations varied within persons)...
May 9, 2023: Sexuality Research & Social Policy
https://read.qxmd.com/read/37354201/a-randomized-clinical-trial-of-online-social-intelligence-training-with-custodial-grandmothers
#19
JOURNAL ARTICLE
Gregory C Smith, Frank J Infurna, Megan Dolbin-MacNab, Britney Webster, Saul Castro, Daniel M Crowley, Carol Musil, Luxin Hu, Gregory R Hancock
BACKGROUND AND OBJECTIVES: In this study, we investigated the efficacy of a self-administered, online Social Intelligence Training (SIT) program aimed at enhancing psychological and relational well-being among a nationwide U.S. sample of custodial grandmothers. RESEARCH DESIGN AND METHODS: A two-arm randomized clinical trial (RCT) was conducted, where 349 grandmothers raising grandchildren aged 11-18 years were assigned to either SIT or an attention control condition (ACC)...
June 24, 2023: Gerontologist
https://read.qxmd.com/read/37181049/first-gene-edited-calf-with-reduced-susceptibility-to-a-major-viral-pathogen
#20
JOURNAL ARTICLE
Aspen M Workman, Michael P Heaton, Brian L Vander Ley, Dennis A Webster, Luke Sherry, Jonathan R Bostrom, Sabreena Larson, Theodore S Kalbfleisch, Gregory P Harhay, Erin E Jobman, Daniel F Carlson, Tad S Sonstegard
Bovine viral diarrhea virus (BVDV) is one of the most important viruses affecting the health and well-being of bovine species throughout the world. Here, we used CRISPR-mediated homology-directed repair and somatic cell nuclear transfer to produce a live calf with a six amino acid substitution in the BVDV binding domain of bovine CD46. The result was a gene-edited calf with dramatically reduced susceptibility to infection as measured by reduced clinical signs and the lack of viral infection in white blood cells...
May 2023: PNAS Nexus
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