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Gregory webster

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https://www.readbyqxmd.com/read/28611205/mouse-pdx-trial-suggests-synergy-of-concurrent-inhibition-of-raf-and-egfr-in-colorectal-cancer-with-braf-or-kras-mutations
#1
Yung-Mae M Yao, Gregory P Donoho, Philip Iversen, Youyan Zhang, Robert D Van Horn, Amelie Forest, Ruslan Novosiadly, Yue Webster, Ebert J Philip, Steven M Bray, Jason C Ting, Amit Aggarwal, James R Henry, Ramon V Tiu, Gregory D Plowman, Sheng-Bin Peng
Purpose: It is to evaluate the anti-tumor efficacy of cetuximab in combination with LSN3074753, an analogue of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer (CRC) patient derived xenograft (PDX) models.<br />Experimental Design: 79 well characterized CRC PDX models were employed to conduct a single mouse per treatment group (n=1) trial.<br />Results: Consistent with clinical results, cetuximab was efficacious in wild type KRAS and BRAF PDX models, with an overall response rate (ORR) of 6...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28528545/discovery-and-biosynthesis-of-gladiolin-a-burkholderia-gladioli-antibiotic-with-promising-activity-against-mycobacterium-tuberculosis
#2
Lijiang Song, Matthew Jenner, Joleen Masschelein, Cerith Jones, Matthew J Bull, Simon R Harris, Ruben C Hartkoorn, Anthony Vocat, Isolda Romero-Canelon, Paul Coupland, Gordon Webster, Matthew Dunn, Rebecca Weiser, Christopher Paisey, Stewart T Cole, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. Gladiolin is structurally related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria. Like etnangien, gladiolin was found to inhibit RNA polymerase, a validated drug target in M. tuberculosis. However, gladiolin lacks the highly labile hexaene moiety of etnangien and was thus found to possess significantly increased chemical stability...
June 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28473996/return-to-sport-in-the-younger-patient-with-anterior-cruciate-ligament-reconstruction
#3
Kate E Webster, Julian A Feller, Timothy S Whitehead, Gregory D Myer, Peter B Merory
BACKGROUND: Although anterior cruciate ligament (ACL) reconstruction is generally regarded as a successful procedure, only 65% of patients return to their preinjury sport. While return-to-sport rates are likely higher in younger patients, there is a paucity of data that focus on the younger patient and their return-to-sport experience after ACL reconstruction. PURPOSE: To investigate a range of return-to-sport outcomes in younger athletes who had undergone ACL reconstruction surgery...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28442890/justification-of-disintegration-testing-beyond-current-fda-criteria-using-in-vitro-and-in-silico-models
#4
Lukas Uebbing, Lukas Klumpp, Gregory K Webster, Raimar Löbenberg
Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR) formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28394045/integrated-care-for-children-a-shared-training-model
#5
Katherine Grimes, Cecil Webster, Sara Coffey, Gregory Hagan
No abstract text is available yet for this article.
May 2017: Medical Education
https://www.readbyqxmd.com/read/28334266/phenopolis-an-open-platform-for-harmonization-and-analysis-of-genetic-and-phenotypic-data
#6
Nikolas Pontikos, Jing Yu, Ismail Moghul, Lucy Withington, Fiona Blanco-Kelly, Tom Vulliamy, Tsz Lun Wong, Cian Murphy, Valentina Cipriani, Alessia Fiorentino, Gavin Arno, Daniel Greene, Julius Ob Jacobsen, Tristan Clark, David S Gregory, Andrea Nemeth, Stephanie Halford, Chris F Inglehearn, Susan Downes, Graeme C Black, Andrew R Webster, Alison J Hardcastle, Vincent Plagnol
Summary: Phenopolis is an open-source web server providing an intuitive interface to genetic and phenotypic databases. It integrates analysis tools such as variant filtering and gene prioritisation based on phenotype. The Phenopolis platform will accelerate clinical diagnosis, gene discovery and encourage wider adoption of the Human Phenotype Ontology in the study of rare genetic diseases. Availability and Implementation: A demo of the website is available at https://phenopolis...
March 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28289673/chronic-suppurative-lung-disease-in-children-definition-and-spectrum-of-disease
#7
REVIEW
Gregory J Redding, Edward R Carter
The most common clinical suppurative lung conditions in children are empyema, lung abscess, and bronchiectasis, and to a less often necrotizing pneumonia. Until recently, bronchiectasis was the most common form of persistent suppurative lung disease in children. Protracted bacterial bronchitis is a newly described chronic suppurative condition in children, which is less persistent but more common than bronchiectasis (1). In addition, the term "chronic suppurative lung disease" has been used recently to describe the clinical features of bronchiectasis when the radiographic features needed to make a diagnosis of bronchiectasis are absent...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28193509/pilot-study-analyzing-automated-ecg-screening-of-hypertrophic-cardiomyopathy
#8
Matthew J Campbell, Xuefu Zhou, Chia Han, Hedayat Abrishami, Gregory Webster, Christina Y Miyake, Christopher T Sower, Jeffrey B Anderson, Timothy K Knilans, Richard J Czosek
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is one of the leading causes of sudden cardiac death in athletes. However, preparticipation ECG screening has often been criticized for failing to meet cost-effectiveness thresholds, in part because of high false-positive rates and the cost of ECG screening itself. OBJECTIVE: The purpose of this study was to assess the testing characteristics of an automated ECG algorithm designed to screen for HCM in a multi-institutional pediatric cohort...
February 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28009655/amiodarone-versus-lidocaine-for-pediatric-cardiac-arrest-due-to-ventricular-arrhythmias-a-systematic-review
#9
Mary E McBride, Bradley S Marino, Gregory Webster, Jesús Lopez-Herce, Carolyn P Ziegler, Allan R De Caen, Dianne L Atkins
OBJECTIVE: We performed a systematic review as part of the International Liaison Committee on Resuscitation process to create a consensus on science statement regarding amiodarone or lidocaine during pediatric cardiac arrest for the 2015 International Liaison Committee on Resuscitation's Consensus on Science and Treatment Recommendations. DATA SOURCES: Studies were identified from comprehensive searches in PubMed, Embase, and the Cochrane Library. STUDY SELECTION: Studies eligible for inclusion were randomized controlled and observational studies on the relative clinical effect of amiodarone or lidocaine in cardiac arrest...
February 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/27799290/federal-actions-to-incentivise-state-adoption-of-0-08%C3%A2-g-dl-blood-alcohol-concentration-laws
#10
Gregory J Tung, Jon S Vernick, Elizabeth A Stuart, Daniel W Webster, Andrea C Gielen
OBJECTIVE: To model rates of 0.08 g/dL blood alcohol concentration (BAC) per se law implementation among the states associated with (1) a federal incentive grant programme and (2) a threat from the federal government to withhold highway transportation funds. METHODS: An observational study of state-level 0.08 g/dL BAC per se law enactment among all 50 US states from 1982 to 2006 using a parametric survival analysis to assess the time-dependent risk of policy enactment...
October 31, 2016: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/27763398/the-deacon-s-mom-wants-to-die
#11
Deacon Gregory Webster
No abstract text is available yet for this article.
2016: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/27763387/narrative-symposium-patient-family-and-clinician-experiences-with-voluntarily-stopping-eating-and-drinking-vsed
#12
Carol Douglas, Bill Lukin, Julie Dziedzic, Katherine Hammond, Elizabeth Jose, Bill Jose, Wendy Kohlhase, Adam Marks, Marilyn Mitchell, Phyllis Shacter, Susan Schaffer Schaffer, And Janet Maelek, Judith Schwarz, Stanley Terman, Gregory Webster, Laurie Ann, David L Brown, Blair Henry
No abstract text is available yet for this article.
2016: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/27719691/a-survey-of-paediatricians-on-the-use-of-electrocardiogram-for-pre-participation-sports-screening
#13
Angira Patel, Gregory Webster, Kendra Ward, John Lantos
Aim The aim of the present study was to determine general paediatrician knowledge, practices, and attitudes towards electrocardiogram (ECG) screening in school athletes during pre-participation screening exam (PPSE). METHODS: Paediatricians affiliated with a tertiary children's hospital completed a survey about ECGs for PPSE. RESULTS: In total, 205/498 (41%) responded; 92% of the paediatricians did not include an ECG as part of PPSE; 56% were aware of a case in which a student athlete in their own community had died of sudden unexplained death; 4% had an athlete in their practice die...
October 10, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27694801/polyketide-and-nonribosomal-peptide-retro-biosynthesis-and-global-gene-cluster-matching
#14
Chris A Dejong, Gregory M Chen, Haoxin Li, Chad W Johnston, Mclean R Edwards, Philip N Rees, Michael A Skinnider, Andrew L H Webster, Nathan A Magarvey
Polyketides (PKs) and nonribosomal peptides (NRPs) are profoundly important natural products, forming the foundations of many therapeutic regimes. Decades of research have revealed over 11,000 PK and NRP structures, and genome sequencing is uncovering new PK and NRP gene clusters at an unprecedented rate. However, only ∼10% of PK and NRPs are currently associated with gene clusters, and it is unclear how many of these orphan gene clusters encode previously isolated molecules. Therefore, to efficiently guide the discovery of new molecules, we must first systematically de-orphan emergent gene clusters from genomes...
December 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27374306/novel-calmodulin-mutations-associated-with-congenital-long-qt-syndrome-affect-calcium-current-in-human-cardiomyocytes
#15
Daniel C Pipilas, Christopher N Johnson, Gregory Webster, Jurg Schlaepfer, Florence Fellmann, Nicole Sekarski, Lisa M Wren, Kateryna V Ogorodnik, Daniel M Chazin, Walter J Chazin, Lia Crotti, Zahurul A Bhuiyan, Alfred L George
BACKGROUND: Calmodulin (CaM) mutations are associated with cardiac arrhythmia susceptibility including congenital long QT syndrome (LQTS). OBJECTIVE: The purpose of this study was to determine the clinical, genetic, and functional features of 2 novel CaM mutations in children with life-threatening ventricular arrhythmias. METHODS: The clinical and genetic features of 2 congenital arrhythmia cases associated with 2 novel CaM gene mutations were ascertained...
October 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27346569/electrocardiography-screening-for-hypertrophic-cardiomyopathy
#16
COMPARATIVE STUDY
Matthew J Campbell, Xuefu Zhou, Chia Han, Hedayat Abrishami, Gregory Webster, Christina Y Miyake, Timothy K Knilans, Richard J Czosek
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the leading cause of sudden cardiac death in athletes. However, preparticipation electrocardiogram (ECG) screening has been criticized for failing to meet cost-effectiveness thresholds, in part because of high false-positive rates. We sought to evaluate whether a highly automated software algorithm could be used for a high throughput, population-based screening program and address several of the limitations seen with population-based screening METHODS: A proprietary computed algorithm was created based on both voltage- as well as Seattle-based ECG criteria...
September 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27251896/current-state-of-concussion-prevention-strategies-a-systematic-review-and-meta-analysis-of-prospective-controlled-studies
#17
Daniel K Schneider, Ravi K Grandhi, Purnima Bansal, George E Kuntz, Kate E Webster, Kelsey Logan, Kim D Barber Foss, Gregory D Myer
OBJECTIVE: The aim of the current review was to systematically identify, evaluate and synthesise trials that examine concussion prevention via equipment, educational programmes and training programmes. DATA SOURCES: PubMed and EBSCO host (CINAHL, MEDLINE, SPORTDiscus). ELIGIBILITY CRITERIA FOR SELECTING STUDIES: The electronic databases PubMed and EBSCO were searched using the phrases: concussion prevention equipment, concussion prevention training and concussion prevention education...
June 1, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27025810/factors-in-the-selection-of-surface-disinfectants-for-use-in-a-laboratory-animal-setting
#18
Michael V Campagna, Emmanuelle Faure-Kumar, Janet A Treger, Jesse D Cushman, Tristan R Grogan, Noriyuki Kasahara, Gregory W Lawson
Because surface disinfectants are an important means of pathogen control within laboratory animal facilities, these products must have an appropriate spectrum of antimicrobial activity. However, many other factors must also be considered, including effects on human health, environmental safety, and animal behavior. Aqueous solutions of sodium hypochlorite often are considered to be the 'gold standard' for surface disinfection, but these products can be corrosive, caustic, and aversive in odor. This study was designed to identify disinfectants that are as effective as hypochlorite solutions but more acceptable for use in a laboratory animal setting...
March 2016: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/26983842/a-concentric-tube-continuum-robot-with-piezoelectric-actuation-for-mri-guided-closed-loop-targeting
#19
Hao Su, Gang Li, D Caleb Rucker, Robert J Webster Iii, Gregory S Fischer
This paper presents the design, modeling and experimental evaluation of a magnetic resonance imaging (MRI)-compatible concentric tube continuum robotic system. This system enables MRI-guided deployment of a precurved and steerable concentric tube continuum mechanism, and is suitable for clinical applications where a curved trajectory is needed. This compact 6 degree-of-freedom (DOF) robotic system is piezoelectrically-actuated, and allows simultaneous robot motion and imaging with no visually observable image artifact...
October 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/26983793/has-virginity-lost-its-virtue-relationship-stigma-associated-with-being-a-sexually-inexperienced-adult
#20
Amanda N Gesselman, Gregory D Webster, Justin R Garcia
While virginity prior to marriage has been historically valued, changing sociosexual scripts in the United States have made premarital sexual activity the norm for young adults, with sexual debut generally occurring in late adolescence. In the current research, we examined the impact of being developmentally off-time with first coitus (i.e., not yet engaging in coitus when most same-aged peers have done so). Specifically, we investigated stigma toward sexually inexperienced adults and discrimination regarding romantic relationship formation...
February 2017: Journal of Sex Research
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