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Gregory webster

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https://www.readbyqxmd.com/read/29759629/circadian-variation-of-ventricular-arrhythmias-in-catecholaminergic-polymorphic-ventricular-tachycardia
#1
Christina Y Miyake, S Yukiko Asaki, Gregory Webster, Richard J Czosek, Joseph Atallah, Kishor Avasarala, Sri O Rao, Patricia E Thomas, Jeffrey J Kim, Santiago O Valdes, Caridad de la Uz, Yunfei Wang, Xander H T Wehrens, Dominic Abrams
OBJECTIVES: The aim of this paper was to investigate whether ventricular arrhythmias in children with catecholaminergic polymorphic ventricular tachycardia (CPVT) show circadian patterns. BACKGROUND: Circadian arrhythmic patterns have been established in long QT, Brugada, and early repolarization, but have not been investigated in CPVT. METHODS: This is a multicenter, retrospective review of pediatric CPVT patients, age <21 years at diagnosis...
November 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29616588/the-relationships-of-intergroup-ideologies-to-ethnic-prejudice-a-meta-analysis
#2
Bernard E Whitley, Gregory D Webster
This meta-analysis summarizes the results of research on the relationships of majority group members' endorsement of assimilation, colorblindness, multiculturalism, and the relative relationships of colorblindness and multiculturalism to ethnic prejudice. Random effects analyses found that assimilation was positively related to explicit prejudice ( g. = 0.80), multiculturalism was negatively related to both explicit ( g. = -0.26) and implicit prejudice ( g. = -0.19), and colorblindness was negatively related to explicit prejudice ( g...
April 1, 2018: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/29599121/-what-s-my-risk-of-sustaining-an-acl-injury-while-playing-football-soccer-a-systematic-review-with-meta-analysis
#3
REVIEW
Alicia M Montalvo, Daniel K Schneider, Paula L Silva, Laura Yut, Kate E Webster, Michael A Riley, Adam W Kiefer, Jennifer L Doherty-Restrepo, Gregory D Myer
OBJECTIVE: To estimate the incidence proportion (IP) and incidence rate (IR) of ACL injury in football players. DESIGN: Systematic review with meta-analysis. DATA SOURCES: PubMed, CINAHL and SPORTDiscus electronic databases were searched from inception to 20 January 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDY: Studies that reported the total number of participants/population by sex, total number of ACL injuries by sex and total person-time by sex were included...
March 29, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29540958/iridium-and-ruthenium-complexes-of-n-heterocyclic-carbene-and-pyridinol-derived-chelates-as-catalysts-for-aqueous-carbon-dioxide-hydrogenation-and-formic-acid-dehydrogenation-the-role-of-the-alkali-metal
#4
Sopheavy Siek, Dalton B Burks, Deidra L Gerlach, Guangchao Liang, Jamie M Tesh, Courtney R Thompson, Fengrui Qu, Jennifer E Shankwitz, Robert M Vasquez, Nicole Chambers, Gregory J Szulczewski, Douglas B Grotjahn, Charles Edwin Webster, Elizabeth T Papish
Hydrogenation reactions can be used to store energy in chemical bonds, and if these reactions are reversible, that energy can be released on demand. Some of the most effective transition metal catalysts for CO2 hydrogenation have featured pyridin-2-ol-based ligands (e.g., 6,6'-dihydroxybipyridine (6,6'-dhbp)) for both their proton-responsive features and for metal-ligand bifunctional catalysis. We aimed to compare bidentate pyridin-2-ol based ligands with a new scaffold featuring an N -heterocyclic carbene (NHC) bound to pyridin-2-ol...
March 27, 2017: Organometallics
https://www.readbyqxmd.com/read/29526098/structure-based-design-of-pyridone-aminal-eft508-targeting-dysregulated-translation-by-selective-mitogen-activated-protein-kinase-interacting-kinases-1-and-2-mnk1-2-inhibition
#5
Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, James R Appleman, Joan Chen, Jeff Clarine, Boreth Eam, Justin T Ernst, Qing Han, Vikas K Goel, Edward Z R Han, Vera Huang, Ivy N J Hung, Adrianna Jemison, Katti A Jessen, Jolene Molter, Douglas Murphy, Melissa Neal, Gregory S Parker, Michael Shaghafi, Samuel Sperry, Jocelyn Staunton, Craig R Stumpf, Peggy A Thompson, Chinh Tran, Stephen E Webber, Christopher J Wegerski, Hong Zheng, Kevin R Webster
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphorylation of eIF4E and other mRNA binding proteins. Modulation of these key effector proteins regulates mRNA, which controls tumor/stromal cell signaling. Compound 23 (eFT508), an exquisitely selective, potent dual MNK1/2 inhibitor, was designed to assess the potential for control of oncogene signaling at the level of mRNA translation...
April 26, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29515227/structured-inpatient-evaluation-of-neonatal-cardiac-ectopy
#6
Irene A Hurst, Gregory Webster, Kerri Z Machut, Nina Gotteiner, Ahmad Sami Chaouki, Elizabeth N Groothuis, Karna Murthy
OBJECTIVE(S): In well-appearing newborns with suspected cardiac ectopy, we sought to evaluate our practice and test whether initial electrocardiogram (ECG) findings were associated with neonatal arrhythmias (NA). STUDY DESIGN: We identified well-appearing, non-anomalous infants >34 weeks' gestation with suspected ectopy over 3.5 years. NA was defined as ≥10% premature atrial contractions (PAC), ≥5 beats of atrial tachycardia, ≥2% premature ventricular contractions (PVCs), or ≥3 beats of ventricular tachycardia...
March 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29514822/-what-s-my-risk-of-sustaining-an-acl-injury-while-playing-sports-a-systematic-review-with-meta-analysis
#7
REVIEW
Alicia M Montalvo, Daniel K Schneider, Laura Yut, Kate E Webster, Bruce Beynnon, Mininder S Kocher, Gregory D Myer
OBJECTIVE: To estimate the incidence proportion (IP) and incidence rate (IR) for ACL injury in athletes. DESIGN: Systematic review with meta-analysis DATA SOURCES: The PubMed, CINAHL and SPORTDiscus electronic databases were searched from inception to 20 January 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies were included if they reported total number of participants/population by sex, total number of ACL injuries by sex and total person-time by sex...
March 7, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29380436/additional-free-reinforcers-increase-persistence-of-problem-behavior-in-a-clinical-context-a-partial-replication-of-laboratory-findings
#8
Gregory A Lieving, Iser G DeLeon, Abbey B Carreau-Webster, Michelle A Frank-Crawford, Mandy M Triggs
Behavioral momentum theory is a quantitative framework used to characterize the persistence of behavior during response disruptors as a function of baseline stimulus-reinforcer relations. Results of several investigations have shown that alternative reinforcement can increase the resistance to change of a target response during extinction. In the present study, concomitant variable-interval fixed-time schedules of reinforcement for problem behavior were employed to simulate naturalistic situations involving the superimposition of response-independent reinforcers on a baseline schedule of reinforcement for problem behavior, as in the common use of noncontingent reinforcement treatments...
January 2018: Journal of the Experimental Analysis of Behavior
https://www.readbyqxmd.com/read/29187111/aiming-at-a-blurry-target-optimal-therapy-for-postoperative-jet
#9
COMMENT
Gregory Webster
No abstract text is available yet for this article.
November 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/29165562/the-diversity-of-recent-and-ancient-human-dream-a-new-microarray-for-genetic-anthropology-and-genealogy-forensics-and-personalized-medicine
#10
Eran Elhaik, Leeban Yusuf, Ainan I J Anderson, Mehdi Pirooznia, Dimitrios Arnellos, Gregory Vilshansky, Gunes Ercal, Yontao Lu, Teresa Webster, Michael L Baird, Umberto Esposito
The human population displays wide variety in demographic history, ancestry, content of DNA derived from hominins or ancient populations, adaptation, traits, copy number variation (CNVs), drug response, and more. These polymorphisms are of broad interest to population geneticists, forensics investigators, and medical professionals. Historically, much of that knowledge was gained from population survey projects. While many commercial arrays exist for genome-wide single-nucleotide polymorphism (SNP) genotyping, their design specifications are limited and they do not allow a full exploration of biodiversity...
November 20, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29074446/efficacy-and-safety-of-digital-single-operator-cholangioscopy-for-difficult-biliary-stones
#11
Olaya I Brewer Gutierrez, Noor L H Bekkali, Isaac Raijman, Richard Sturgess, Divyesh V Sejpal, Hanaa D Aridi, Stuart Sherman, Raj J Shah, Richard S Kwon, James L Buxbaum, Claudio Zulli, Wahid Wassef, Douglas G Adler, Vladimir Kushnir, Andrew Y Wang, Kumar Krishnan, Vivek Kaul, Demetrios Tzimas, Christopher J DiMaio, Sammy Ho, Bret Petersen, Jong Ho Moon, B Joseph Elmunzer, George J M Webster, Yen-I Chen, Laura K Dwyer, Summant Inamdar, Vanessa B Patrick, Augustin Attwell, Amy Hosmer, Christopher Ko, Attilio Maurano, Avik Sarkar, Linda J Taylor, Martin H Gregory, Daniel S Strand, Ali Raza, Shivangi Kothari, Jessica P Harris, Nikhil A Kumta, Amar Manvar, Mark D Topazian, Yun Nah Lee, Clayton M Spiceland, Majidah A Bukhari, Omid Sanaei, Saowanee Ngamruengphong, Mouen A Khashab
BACKGROUND & AIMS: It is not clear whether digital single-operator cholangioscopy (D-SOC) with electrohydraulic and laser lithotripsy is effective in removal of difficult biliary stones. We investigated the safety and efficacy of D-SOC with electrohydraulic and laser lithotripsy in an international, multicenter study of patients with difficult biliary stones. METHODS: We performed a retrospective analysis of 407 patients (60.4% female; mean age, 64.2 years) who underwent D-SOC for difficult biliary stones at 22 tertiary centers in the United States, United Kingdom, or Korea from February 2015 through December 2016; 306 patients underwent electrohydraulic lithotripsy and 101 (24...
October 24, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29074376/industry-s-view-on-using-quality-control-biorelevant-and-clinically-relevant-dissolution-tests-for-pharmaceutical-development-registration-and-commercialization
#12
REVIEW
Haiyan Grady, David Elder, Gregory K Webster, Yun Mao, Yiqing Lin, Talia Flanagan, James Mann, Andy Blanchard, Michael J Cohen, Judy Lin, Filippos Kesisoglou, Andre Hermans, Andreas Abend, Limin Zhang, David Curran
This article intends to summarize the current views of the IQ Consortium Dissolution Working Group, which comprises various industry companies, on the roles of dissolution testing throughout pharmaceutical product development, registration, commercialization, and beyond. Over the past 3 decades, dissolution testing has evolved from a routine and straightforward test as a component of end-product release into a comprehensive set of tools that the developer can deploy at various stages of the product life cycle...
January 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28831727/approaches-for-establishing-clinically-relevant-dissolution-specifications-for-immediate-release-solid-oral-dosage-forms
#13
Andre Hermans, Andreas M Abend, Filippos Kesisoglou, Talia Flanagan, Michael J Cohen, Dorys A Diaz, Y Mao, Limin Zhang, Gregory K Webster, Yiqing Lin, David A Hahn, Carrie A Coutant, Haiyan Grady
This manuscript represents the perspective of the Dissolution Analytical Working Group of the IQ Consortium. The intent of this manuscript is to highlight the challenges of, and to provide a recommendation on, the development of clinically relevant dissolution specifications (CRS) for immediate release (IR) solid oral dosage forms. A roadmap toward the development of CRS for IR products containing active ingredients with a non-narrow therapeutic window is discussed, within the context of mechanistic dissolution understanding, supported by in-human pharmacokinetic (PK) data...
November 2017: AAPS Journal
https://www.readbyqxmd.com/read/28611205/mouse-pdx-trial-suggests-synergy-of-concurrent-inhibition-of-raf-and-egfr-in-colorectal-cancer-with-braf-or-kras-mutations
#14
Yung-Mae M Yao, Gregory P Donoho, Philip W Iversen, Youyan Zhang, Robert D Van Horn, Amelie Forest, Ruslan D Novosiadly, Yue Wang Webster, Philip Ebert, Steven Bray, Jason C Ting, Amit Aggarwal, James R Henry, Ramon V Tiu, Gregory D Plowman, Sheng-Bin Peng
Purpose: To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer patient-derived xenograft (PDX) models.Experimental Design: Seventy-nine well-characterized colorectal cancer PDX models were employed to conduct a single mouse per treatment group (n = 1) trial.Results: Consistent with clinical results, cetuximab was efficacious in wild-type KRAS and BRAF PDX models, with an overall response rate of 6.3% and disease control rate (DCR) of 20...
June 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28528545/discovery-and-biosynthesis-of-gladiolin-a-burkholderia-gladioli-antibiotic-with-promising-activity-against-mycobacterium-tuberculosis
#15
Lijiang Song, Matthew Jenner, Joleen Masschelein, Cerith Jones, Matthew J Bull, Simon R Harris, Ruben C Hartkoorn, Anthony Vocat, Isolda Romero-Canelon, Paul Coupland, Gordon Webster, Matthew Dunn, Rebecca Weiser, Christopher Paisey, Stewart T Cole, Julian Parkhill, Eshwar Mahenthiralingam, Gregory L Challis
An antimicrobial activity screen of Burkholderia gladioli BCC0238, a clinical isolate from a cystic fibrosis patient, led to the discovery of gladiolin, a novel macrolide antibiotic with potent activity against Mycobacterium tuberculosis H37Rv. Gladiolin is structurally related to etnangien, a highly unstable antibiotic from Sorangium cellulosum that is also active against Mycobacteria. Like etnangien, gladiolin was found to inhibit RNA polymerase, a validated drug target in M. tuberculosis. However, gladiolin lacks the highly labile hexaene moiety of etnangien and was thus found to possess significantly increased chemical stability...
June 5, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28473996/return-to-sport-in-the-younger-patient-with-anterior-cruciate-ligament-reconstruction
#16
Kate E Webster, Julian A Feller, Timothy S Whitehead, Gregory D Myer, Peter B Merory
BACKGROUND: Although anterior cruciate ligament (ACL) reconstruction is generally regarded as a successful procedure, only 65% of patients return to their preinjury sport. While return-to-sport rates are likely higher in younger patients, there is a paucity of data that focus on the younger patient and their return-to-sport experience after ACL reconstruction. PURPOSE: To investigate a range of return-to-sport outcomes in younger athletes who had undergone ACL reconstruction surgery...
April 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28442890/justification-of-disintegration-testing-beyond-current-fda-criteria-using-in-vitro-and-in-silico-models
#17
Lukas Uebbing, Lukas Klumpp, Gregory K Webster, Raimar Löbenberg
Drug product performance testing is an important part of quality-by-design approaches, but this process often lacks the underlying mechanistic understanding of the complex interactions between the disintegration and dissolution processes involved. Whereas a recent draft guideline by the US Food and Drug Administration (FDA) has allowed the replacement of dissolution testing with disintegration testing, the mentioned criteria are not globally accepted. This study provides scientific justification for using disintegration testing rather than dissolution testing as a quality control method for certain immediate release (IR) formulations...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28394045/integrated-care-for-children-a-shared-training-model
#18
Katherine Grimes, Cecil Webster, Sara Coffey, Gregory Hagan
No abstract text is available yet for this article.
May 2017: Medical Education
https://www.readbyqxmd.com/read/28334266/phenopolis-an-open-platform-for-harmonization-and-analysis-of-genetic-and-phenotypic-data
#19
Nikolas Pontikos, Jing Yu, Ismail Moghul, Lucy Withington, Fiona Blanco-Kelly, Tom Vulliamy, Tsz Lun Ernest Wong, Cian Murphy, Valentina Cipriani, Alessia Fiorentino, Gavin Arno, Daniel Greene, Julius O B Jacobsen, Tristan Clark, David S Gregory, Andrea M Nemeth, Stephanie Halford, Chris F Inglehearn, Susan Downes, Graeme C Black, Andrew R Webster, Alison J Hardcastle, Vincent Plagnol
Summary: Phenopolis is an open-source web server providing an intuitive interface to genetic and phenotypic databases. It integrates analysis tools such as variant filtering and gene prioritization based on phenotype. The Phenopolis platform will accelerate clinical diagnosis, gene discovery and encourage wider adoption of the Human Phenotype Ontology in the study of rare genetic diseases. Availability and Implementation: A demo of the website is available at https://phenopolis...
August 1, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28289673/chronic-suppurative-lung-disease-in-children-definition-and-spectrum-of-disease
#20
REVIEW
Gregory J Redding, Edward R Carter
The most common clinical suppurative lung conditions in children are empyema, lung abscess, and bronchiectasis, and to a less often necrotizing pneumonia. Until recently, bronchiectasis was the most common form of persistent suppurative lung disease in children. Protracted bacterial bronchitis is a newly described chronic suppurative condition in children, which is less persistent but more common than bronchiectasis (1). In addition, the term "chronic suppurative lung disease" has been used recently to describe the clinical features of bronchiectasis when the radiographic features needed to make a diagnosis of bronchiectasis are absent...
2017: Frontiers in Pediatrics
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