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https://www.readbyqxmd.com/read/28454483/efficient-carrier-injection-transport-relaxation-and-recombination-associated-with-a-stronger-carrier-localization-and-a-low-polarization-effect-of-nonpolar-m-plane-ingan-gan-light-emitting-diodes
#1
Fann-Wei Yang, Yu-Siang You, Shih-Wei Feng
Based on time-resolved electroluminescence (TREL) measurement, more efficient carrier injection, transport, relaxation, and recombination associated with a stronger carrier localization and a low polarization effect in a nonpolar m-plane InGaN/GaN light emitting diode (m-LED), compared with those in a polar c-LED, are reported. With a higher applied voltage in the c-LED, decreasing response time and rising time improve device performance, but a longer recombination time degrades luminescence efficiency. By using an m-LED with a stronger carrier localization and a low polarization effect, shorter response, rising, and recombination times provide more efficient carrier injection, transport, relaxation, and recombination...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454481/aln-surface-passivation-of-gan-based-high-electron-mobility-transistors-by-plasma-enhanced-atomic-layer-deposition
#2
An-Jye Tzou, Kuo-Hsiung Chu, I-Feng Lin, Erik Østreng, Yung-Sheng Fang, Xiao-Peng Wu, Bo-Wei Wu, Chang-Hong Shen, Jia-Ming Shieh, Wen-Kuan Yeh, Chun-Yen Chang, Hao-Chung Kuo
We report a low current collapse GaN-based high electron mobility transistor (HEMT) with an excellent thermal stability at 150 °C. The AlN was grown by N2-based plasma enhanced atomic layer deposition (PEALD) and shown a refractive index of 1.94 at 633 nm of wavelength. Prior to deposit AlN on III-nitrides, the H2/NH3 plasma pre-treatment led to remove the native gallium oxide. The X-ray photoelectron spectroscopy (XPS) spectroscopy confirmed that the native oxide can be effectively decomposed by hydrogen plasma...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454475/oridonin-induces-g2-m-cell-cycle-arrest-and-apoptosis-via-the-pi3k-akt-signaling-pathway-in-hormone-independent-prostate-cancer-cells
#3
Jianlei Lu, Xiang Chen, Shuang Qu, Bing Yao, Yuexin Xu, Jiahui Wu, Yucui Jin, Changyan Ma
Oridonin is an active constituent isolated from the traditional Chinese herb Rabdosia rubescens, which exerts antitumor effects in experimental and clinical settings. However, its antitumor effects and underlying mechanisms on prostate cancer cells have not yet been clearly identified. In the present study, the androgen-independent prostate cancer PC3 and DU145 cell lines were used as models to investigate the effects and possible mechanisms of oridonin on cellular proliferation and apoptosis. Results demonstrated that oridonin inhibited cellular proliferation, and was able to significantly induce G2/M cell cycle arrest and apoptosis...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454470/terrein-performs-antitumor-functions-on-esophageal-cancer-cells-by-inhibiting-cell-proliferation-and-synergistic-interaction-with-cisplatin
#4
Yanqing Wu, Yinghua Zhu, Shunrong Li, Minhua Zeng, Junjun Chu, Pengnan Hu, Jingjing Li, Qiannan Guo, Xiao-Bin Lv, Guofu Huang
Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated and the possible underlying mechanisms were investigated. The results revealed that terrein inhibited the proliferation of Eca109 esophageal cancer cells in a dose- and time-dependent manner. Mechanistically, terrein treatment led to the G2/M phase arrest of Eca109 cells by indirectly regulating cyclin B1 and phosphorylating the cell division cycle protein 2 genes...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454418/epigenetic-silencing-of-protocadherin-10-in-colorectal-cancer
#5
Xian Zhong, Hong Shen, Jianshan Mao, Jiawei Zhang, Weidong Han
Colorectal cancer (CRC) is one of the most common types of malignant tumor in the world and occurs through a multi-step process resulting from the accumulation of genetic and epigenetic alterations of the genome. Although the molecular mechanisms of the pathogenesis of CRC remain unclear, the inactivation of tumor suppressor genes (TSGs) through promoter methylation serves an important role. Aberrant methylation is a well-defined marker of CRC. At present, the epigenetic silencing of protocadherin 10 (PCDH10) has been identified as an important TSG with key roles in colorectal carcinogenesis, invasion and metastasis as a frequent and early event...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454368/anti-osteoclastic-agent-denosumab-for-a-giant-cell-tumor-of-the-bone-with-concurrent-paget-s-disease-a-case-report
#6
Takaaki Tanaka, John Slavin, Sue-Anne McLachlan, Peter Choong
Paget's disease of the bone may predispose the development of malignant bone tumors such as osteosarcoma. Giant cell tumor (GCT) as a consequence of Paget's disease is rare. Bone GCT is characterized by rapid growth, the destruction of bone, extension to the surrounding soft tissue and abnormal bone turnover caused by an abnormality of the receptor activator of nuclear factor-κB (RANK)-RANK ligand (RANKL) pathway. Denosumab is a RANK-RANKL inhibitor, which is used to treat osteoporosis and bone GCT. In the current study, a 60-year-old male presented with severe pain located between the right thigh and the knee...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454325/mir-600-inhibits-cell-proliferation-migration-and-invasion-by-targeting-p53-in-mutant-p53-expressing-human-colorectal-cancer-cell-lines
#7
Peili Zhang, Zhigui Zuo, Aihua Wu, Wenjing Shang, Ruichun Bi, Qike Jin, Jianbo Wu, Lei Jiang
Mutations of the tumor protein p53 gene, a tumor suppressor, are one of the most frequent genetic alterations observed in cancer. It has been reported that mutations in p53 result in the loss of wild-type p53 activity, and the gain of novel oncogenic properties that promote tumor growth and progression. Recent studies have demonstrated that a number of microRNAs (miRs) are involved in the post-transcriptional regulation of p53. The present study demonstrates that miR-600 is a direct negative regulator of p53 through binding a site in the 3' untranslated region of p53 mRNA in human colorectal cancer (CRC) cells...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454300/single-cell-genomic-profiling-of-acute-myeloid-leukemia-for-clinical-use-a-pilot-study
#8
Benedict Yan, Yongli Hu, Kenneth H K Ban, Zenia Tiang, Christopher Ng, Joanne Lee, Wilson Tan, Lily Chiu, Tin Wee Tan, Elaine Seah, Chin Hin Ng, Wee-Joo Chng, Roger Foo
Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, and may improve clinical diagnosis through the identification and characterization of putative subclonal populations. In the present study, the challenges associated with a single-cell genomics profiling workflow for clinical diagnostics were investigated...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454297/association-between-hyperpolarization-activated-channel-in-interstitial-cells-of-cajal-and-gastrointestinal-dysmotility-induced-by-malignant-ascites
#9
Tieyun Guo, Jiade Li, Jing Li, Dan Kong, Chunli Bi, Zheng He, Dai Tang, Xiaoming Jin, Lianhong Jin
Advanced malignant ascites is accompanied by gastrointestinal dysmotility, and patients often feel abdominal pain, abdominal distention, nausea and constipation. Gastrointestinal dysmotility is not only painful for the patients, but it reduces the absorption of nutrients and affects the physical recovery of patients with malignant ascites. It is reported that changes in interstitial cells of Cajal (ICCs) are responsible for the gastrointestinal dysmotility induced by malignant ascites, but the mechanism is not completely understood...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454237/marcks-phosphorylation-is-modulated-by-a-peptide-mimetic-of-marcks-effector-domain-leading-to-increased-radiation-sensitivity-in-lung-cancer-cell-lines
#10
Timothy D Rohrbach, Robert B Jones, Patricia H Hicks, Alice N Weaver, Tiffiny S Cooper, Nicholas J Eustace, Eddy S Yang, John S Jarboe, Joshua C Anderson, Christopher D Willey
Lung cancer is the leading cause of cancer-associated mortality in the United States. Kinase hyperactivation is a known mechanism of tumorigenesis. The phosphorylation status of the plasma membrane-associated protein myristoylated alanine rich C-kinase substrate (MARCKS) effector domain (ED) was previously established as being important in the sensitivity of lung cancer to radiation. Specifically, when MARCKS ED was in a non-phosphorylated state, lung cancer cells were more susceptible to ionizing radiation and experienced prolonged double-strand DNA breaks...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454214/genome-wide-analysis-of-gynecologic-cancer-the-cancer-genome-atlas-in-ovarian-and-endometrial-cancer
#11
Moito Iijima, Kouji Banno, Ryuichiro Okawa, Megumi Yanokura, Miho Iida, Takashi Takeda, Haruko Kunitomi-Irie, Masataka Adachi, Kanako Nakamura, Kiyoko Umene, Yuya Nogami, Kenta Masuda, Eiichiro Tominaga, Daisuke Aoki
Cancer typically develops due to genetic abnormalities, but a single gene abnormality cannot completely account for the onset of cancer. The Cancer Genome Atlas (CGA) project was conducted for the cross-sectional genome-wide analysis of numerous genetic abnormalities in various types of cancer. This approach has facilitated the identification of novel AT-rich interaction domain 1A gene mutations in ovarian clear cell carcinoma, frequent tumor protein 53 (TP53) gene mutations in high-grade ovarian serous carcinoma, and Kirsten rat sarcoma and B-rapidly accelerated fibrosarcoma proto-oncogene, serine/threonine kinase gene mutations in low-grade ovarian serous carcinoma...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454198/-no-magic-bullet-genetic-diagnostics-and-predictive-testing
#12
Heiko Witt
The enormous increase in knowledge about the genetic basis of human diseases, combined with the rapid development of genetic techniques, has led to the possible use of genetic tests in medical diagnostics to a degree previously unknown. In addition, predictive genetic diagnostics has the aim of identifying hereditary disease risks in healthy individuals in order to take precautionary measures. However, the assessment of genetic findings is still subject to numerous problems. In particular, in the case of disease prediction, only probability statements can be made since endogenous and exogenous factors influence the penetrance and expressivity of genetically determined diseases...
May 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28454189/assessment-of-the-authenticity-of-herbal-dietary-supplements-comparison-of-chemical-and-dna-barcoding-methods
#13
Rahul S Pawar, Sara M Handy, Raymond Cheng, Nicole Shyong, Erich Grundel
About 7 % of the U. S. population reports using botanical dietary supplements. Increased use of such supplements has led to discussions related to their authenticity and quality. Reports of adulteration with substandard materials or pharmaceuticals are of concern because such substitutions, whether inadvertent or deliberate, may reduce the efficacy of specific botanicals or lead to adverse events. Methods for verifying the identity of botanicals include macroscopic and microscopic examinations, chemical analysis, and DNA-based methods including DNA barcoding...
April 28, 2017: Planta Medica
https://www.readbyqxmd.com/read/28454116/neuroprotection-by-ifn-%C3%AE-via-astrocyte-secreted-il-6-in-acute-neuroinflammation
#14
Lijie Sun, Yan Li, Xiuzhi Jia, Qi Wang, Yue Li, Minghui Hu, Linlu Tian, Jinfeng Yang, Wenjing Xing, Weihua Zhang, Jingtao Wang, Hongwei Xu, Lihua Wang, Dekai Zhang, Huan Ren
Inflammation eliminates pathogenic infections while also threatening the integrity of the central nervous system. In this study, using in vivo and in vitro models of acute neuroinflammation, we investigated the mechanisms by which inflammation and astrocytes affect neuronal apoptosis. The in vitro model mimicked acute neuroinflammation by incubation in IFN-γ-containing media with primary cultured cerebellar granule neurons, with or without cultured astrocytes. This quickly induced neuronal apoptosis characterized by cleaved caspase-3 expression, Hoechst 33342 staining, and intercellular Ca2+ influx, whereas the presence of astrocytes significantly protected neurons from these effects...
April 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454090/peroxiredoxin-6-overexpression-attenuates-lipopolysaccharide-induced-acute-kidney-injury
#15
Dong Hun Lee, Ju Ho Park, Sang Bae Han, Do Young Yoon, Yu Yeon Jung, Jin Tae Hong
Peroxiredoxin 6 (PRDX6) is a member of the PRDX family of antioxidant enzymes and correlated with inflammatory response. Therefore, we investigated the role of PRDX6 during lipopolysaccharide (LPS)-induced acute kidney injury. Both 3 months aged PRDX6-overexpressing transgenic mice (PRDX6 mice) and wild type (WT) mice had acute renal injury induced by intraperitoneal injection of LPS (10 mg/kg)., PRDX6 mice showed decreased mortality and renal injury following LPS challenge compared to WT mice. Furthermore, infiltration of macrophages, T-cells and neutrophils, and the number of apoptotic cells were more decreased by LPS treatment in PRDX6 mice than in WT mice...
April 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28454049/response-surface-method-optimization-of-a-novel-hypericin-formulation-in-p123-micelles-for-colorectal-cancer-and-antimicrobial-photodynamic-therapy
#16
Maiara Camotti Montanha, Larissa Lachi Silva, Fernanda Belincanta Borghi Pangoni, Gabriel Batista Cesar, Renato Sonchini Gonçalves, Wilker Caetano, Noboru Hioka, Tania Toyomi Tominaga, Márcia Edilaine Lopes Consolaro, Andréa Diniz, Elza Kimura
The photodynamic properties of Hypericin (Hyp) may be used as an alternative treatment for malignancies of the lower gastrointestinal tract and for the prevention of surgical-site infection; however, its use in photodynamic therapy has been limited because of its poor hydrosolubility. Therefore, in order to improve its water solubility and its photodynamic effect, Hyp was encapsulated in Pluronic P123 (P123) and the photodynamic effects against intestinal and epidermal bacteria and against two lineages of intestinal colon carcinoma cells were investigated...
April 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28454047/use-of-light-emitting-diodes-leds-for-enhanced-lipid-production-in-micro-algae-based-biofuels
#17
Alifha Severes, Shashank Hegde, L D'Souza, Smitha Hegde
Microalgae are an alternative source for renewable energy to overcome the energy crises caused by exhaustion of fuel reserves. Algal biofuel technology demands a cost effective strategy for net profitable productivity. Inconsistent illumination intensities hinder microalgal growth. The light-utilizing efficiency of the cells is critical. Light scarcity leads to low production and high intensities cause photo-inhibition. We report effective usage of LEDs of different band wavelengths on the growth of microalgae in a closed, controlled environment to generate biomass and lipid yields...
April 20, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28454044/unintended-impacts-of-regulatory-changes-to-british-columbia-methadone-maintenance-program-on-addiction-and-hiv-related-outcomes-an-interrupted-time-series-analysis
#18
M Eugenia Socías, Evan Wood, Ryan McNeil, Thomas Kerr, Huiru Dong, Jean Shoveller, Julio Montaner, M-J Milloy
BACKGROUND: In February 2014, several regulatory reforms were introduced to the methadone maintenance treatment (MMT) program in British Columbia, Canada, including a switch to a ten-times more concentrated methadone formulation and restrictions in pharmacy delivery services. We evaluated possible unintended effects of these changes on illicit drug use patterns and HIV treatment outcomes among HIV-positive opioid users. METHODS: Data was drawn from ACCESS, a prospective community-recruited cohort of HIV-positive people who use illicit drugs in Vancouver, Canada...
April 25, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28454038/long-term-variations-measurement-of-electromagnetic-field-exposures-in-alcal%C3%A3-de-henares-spain
#19
R Sánchez-Montero, C Alén-Cordero, P L López-Espí, J M Rigelsford, F Aguilera-Benavente, J Alpuente-Hermosilla
Electromagnetic radiowave exposure is a major concern in most countries due to possible adverse health effects. Over the last 10years, many technological changes (digital television, mobile technologies, wireless networks…) have led to variations in the electromagnetic field (EMF) levels. A large number of studies devoted to the analysis of EMF levels with personal dosimeters or computer models of the exposure of mobile stations have been conducted. However, the study of the exposure values, taking into account all the existing sources, and their evolution in a wide area, using measurements, has rarely been performed...
April 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28454017/the-nexus-between-urbanization-and-pm2-5-related-mortality-in-china
#20
Miaomiao Liu, Yining Huang, Zhou Jin, Zongwei Ma, Xingyu Liu, Bing Zhang, Yang Liu, Yang Yu, Jinnan Wang, Jun Bi, Patrick L Kinney
The launch of China's new national urbanization plan, coupled with increasing concerns about air pollution, calls for better understandings of the nexus between urbanization and the air pollution-related health. Based on refined estimates of PM2.5 related mortality in China, we developed an Urbanization-Excess Deaths Elasticity (U-EDE) indicator to measure the marginal PM2.5 related mortality caused by urbanization. We then applied statistical models to estimate U-EDE and examined the modification effects of income on U-EDE...
April 25, 2017: Environmental Pollution
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