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https://www.readbyqxmd.com/read/28738608/a-fast-bioanalytical-method-based-on-microextraction-by-packed-sorbent-and-uplc-ms-ms-for-determining-new-psychoactive-substances-in-oral-fluid
#1
A M Ares, P Fernández, M Regenjo, A M Fernández, A M Carro, R A Lorenzo
The emergence in recent years of potentially dangerous new psychoactive substances (NPS) that are not under international control has led to the development of multi-analyte procedures for their unequivocal quantification. A fast ultra-performance liquid chromatography-tandem mass spectrometry method (UPLC-MS/MS), in combination with a sample pretreatment based on microextraction by packed sorbent (MEPS), was for the first time used in this work for the simultaneous determination of NPS in oral fluid. This matrix is an effective alternative to typical biological samples for drug control in substitution therapy programs, and also for the prevention and reduction of traffic accidents...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738599/development-of-a-chemiluminescent-dna-fibre-optic-genosensor-to-hepatitis-a-virus-hav
#2
Kehan Ye, Marisa Manzano, Riccardo Muzzi, Karina Yew-Hoong Gin, Nazanin Saeidi, Shin Giek Goh, Alfred Iing Yoong Tok, Robert S Marks
Hepatitis A virus (HAV) infection has caused substantial morbidity and economic losses to human society, presenting a major public health problem in many parts of the world. Despite the capability for low-concentration detection, current PCR-based techniques are limited by the requirement of specialized lab equipment, trained personnel and a relatively large time-commitment. The need for a prompt in-field quantitative identification of HAV in real samples has led us to develop a chemiluminescent fibre optic genosensor system...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738450/the-effect-of-pressure-on-organic-reactions-in-fluids-a-new-theoretical-perspective
#3
REVIEW
Bo Chen, Roald Hoffmann, Roberto Cammi
This Review brings a new perspective to the study of chemical reactions in compressed fluid media. We begin by reviewing the substantial insight gained from more than 50 years of experimental studies on organic reactions in solution under pressure. These led to a proper estimation of the critical roles of volume of activation (Δ(≠) V) and reaction volume (ΔV) in understanding pressure effect on rates and equilibria of organic reactions. A recently developed computational method, the XP-PCM (extreme pressure polarizable continuum model) method, capable of carrying out quantum mechanical calculations of reaction pathways of molecules under pressure, is introduced...
July 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28738440/issr-derived-species-specific-scar-marker-for-rapid-and-accurate-authentication-of-ocimum-tenuiflorum-l
#4
Amit Kumar, Vereena Rodrigues, Priyanka Mishra, Kuppusamy Baskaran, Ashutosh K Shukla, Ajit K Shasany, Velusamy Sundaresan
Ocimum tenuiflorum has been widely used in traditional medicine and has high medicinal value. High volume trade of this potential medicinal plant species led to unscrupulous adulteration of both crude drugs as well as formulations. Morphology-based authentication is difficult in cases of incomplete or damaged samples and in dried herbal materials. In such cases, PCR-based molecular methods may aid in accurate identification. The present study aimed at developing species-specific DNA marker(s) for the authentication of O...
July 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28738439/terpenoids-from-the-oleo-gum-resin-of-boswellia-serrata-and-their-antiplasmodial-effects-in-vitro
#5
Hippolyt L Greve, Marcel Kaiser, Reto Brun, Thomas J Schmidt
In the course of our ongoing search for new natural products as leads against protozoal diseases, the dichloromethane extract of Indian frankincense, the oleo-gum-resin obtained from Boswellia serrata, showed in vitro activity against Plasmodium falciparum. Bioactivity-guided fractionation led to the isolation of eight diterpenes: (1S,3E,7E,11R)-verticilla-3,7,12(18)-triene (1), cembrene A (2), serratol (3), 1S,3E,7R,8R,11E-7,8-epoxy-cembra-3,11-dien-1-ol (4), incensole oxide (5), rel (1S,3R,7E,11S,12R)-1,12-epoxy-4-methylenecembr-7-ene-3, 11-diol (6), isoincensole oxide (7), and isodecaryiol (8)...
July 24, 2017: Planta Medica
https://www.readbyqxmd.com/read/28738383/hydralazine-is-a-suitable-mimetic-agent-of-hypoxia-to-study-the-impact-of-hypoxic-stress-on-in-vitro-blood-brain-barrier-model
#6
Morgane Chatard, Clémentine Puech, Nathalie Perek, Frédéric Roche
BACKGROUND/AIMS: Understanding cellular mechanisms induced by hypoxia is fundamental to reduce blood-brain barrier (BBB) disruption. Nevertheless, the investigation of hypoxia on cellular pathways is complex with true hypoxia because HIF-1α has a short lifetime and rapidly reverts back to a normoxic state. To overcome this difficulty, mimetic agents of the hypoxia pathway have been developed, including the gold standard CoCl2. In this study, we proposed to compare CoCl2 and hydralazine in order to determine a suitable mimetic agent of hypoxia for the study on the BBB...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738342/a-succinct-history-of-sleep-medicine
#7
Leh-Kiong Anne Huon, Christian Guilleminault
Although sleep and sleep disorders have been studied for centuries, it was the development of sophisticated tools to monitor eye movements, brain waves, and muscle tone in the mid-20th century that led to modern sleep research. These tools allowed neuroscientists to distinguish between different "states" or "phases" of sleep, and to relate these findings to sleep disorders. This review chronicles the groundbreaking work of the pioneers in this field, and the impact their findings have had on patients today.
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738295/does-the-effect-of-one-day-simulation-team-training-in-obstetric-emergencies-decline-within-one-year-a-post-hoc-analysis-of-a-multicentre-cluster-randomised-controlled-trial
#8
J van de Ven, A F Fransen, E Schuit, P J van Runnard Heimel, B W Mol, S G Oei
Does the effect of one-day simulation team training in obstetric emergencies decline within one year? A post-hoc analysis of a multicentre cluster randomised controlled trial. J van de Ven, AF Fransen, E Schuit, PJ van Runnard Heimel, BW Mol, SG Oei OBJECTIVE: To investigate whether the effect of a one-day simulation-based obstetric team training on patient outcome changes over time. STUDY DESIGN: Post-hoc analysis of a multicentre, open, randomised controlled trial that evaluated team training in obstetrics (TOSTI study)...
July 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28738256/p53-and-mitf-bcl-2-identified-as-key-pathways-in-the-acquired-resistance-of-nras-mutant-melanoma-to-mek-inhibition
#9
Ahmad Najem, Mohammad Krayem, François Salès, Nader Hussein, Bassam Badran, Caroline Robert, Ahmad Awada, Fabrice Journe, Ghanem E Ghanem
Activating mutations in Neuroblastoma RAS viral oncogene homolog (NRAS) are found in 15-30% of melanomas and are associated with a poor prognosis. Although MAP kinase kinase (MEK) inhibitors used as single agents showed a limited clinical benefit in patients with NRAS-mutant melanoma due to their rather cytostatic effect and high toxicity, their combination with other inhibitors of pathways known to cooperate with MEK inhibition may maximise their antitumour activity. Similarly, in a context where p53 is largely inactivated in melanoma, hyperexpression of Microphthalmia associated transcription factor (MITF) and its downstream anti-apoptotic targets may be the cause of the restraint cytotoxic effects of MEK inhibitors...
July 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28738239/delayed-graft-duodenal-perforation-due-to-impacted-food-five-years-after-simultaneous-pancreas-kidney-transplantation-a-case-report
#10
Taizo Sakata, Hideki Katagiri, Tadao Kubota, Takashi Sakamoto, Kentaro Yoshikawa, Alan Kawarai Lefor, Cheol Woong Jung, Toru Kojima
INTRODUCTION: Pancreas transplantation is the best treatment option in selected patients with type 1 diabetes mellitus. Here we report a patient with a nonmarginal duodenal perforation five years after a simultaneous pancreas-living donor kidney transplantation (SPLKT). PRESENTATION OF CASE: A 31-year old male who underwent SPLKT five years previously presented with severe abdominal pain. He had a marginal duodenal perforation four years later, treated by primary closure and drainage...
July 14, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28738201/interbasin-water-transfer-for-the-rehabilitation-of-a-transboundary-mediterranean-stream-an-economic-analysis
#11
Ariel Akron, Andrea Ghermandi, Tamar Dayan, Yaron Hershkovitz
Global demand for freshwater is increasing as human population grows, climate changes and water resources are being overexploited. Consequently, many freshwater ecosystems, particularly in water-stressed regions, are severely degraded. Here we present a unique case of an Interbasin Water Transfer (IWT) project aiming at ecosystem rehabilitation and recreation enhancement of an intermittent transboundary stream (Ayun, Israel). For the past century, water diversion at the Lebanese side had led to flow secession in the Israeli Ayun Nature Reserve during the dry season (May-November)...
July 21, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28738152/natural-products-and-their-mimics-as-targets-of-opportunity-for-discovery
#12
Stephen F Martin
Diverse structural types of natural products and their mimics have served as targets of opportunity in our laboratory to inspire the discovery and development of new methods and strategies to assemble polyfunctional and polycyclic molecular architectures. Furthermore, our efforts toward identifying novel compounds having useful biological properties led to the creation of new targets, many of which posed synthetic challenges that required the invention of new methodology. In this Perspective, selected examples of how we have exploited a diverse range of natural products and their mimics to create, explore, and solve a variety of problems in chemistry and biology will be discussed...
July 24, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28738044/survivorship-model-of-care-development-and-implementation-of-a-nurse-practitioner-led-intervention-for-patients-with-breast-cancer%C3%A2
#13
Kathryn E Post, Beverly Moy, Catherine Furlani, Elizabeth Strand, Jane Flanagan, Jeffrey M Peppercorn
BACKGROUND: Despite a call for action to improve survivorship care, no optimal model of care exists. 
. OBJECTIVES: To develop and evaluate the feasibility of a nurse practitioner (NP)-led model of care for survivorship visits after initial therapy. 
. METHODS: Patients received an NP-led survivorship bridge visit (NPSBV) following treatment for early-stage breast cancer. A cross-sectional survey was used to evaluate responses to the NPSBV and patient satisfaction with care...
August 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28737970/the-photocatalytic-degradation-of-methylene-blue-by-green-semiconductor-films-that-is-induced-by-irradiation-by-a-light-emitting-diode-and-visible-light
#14
Chih-Chi Yang, Ruey-An Doong, Ku-Fan Chen, Giin-Shan Chen, Yung-Pin Tsai
This study develops a low-energy rotating photocatalytic contactor (LE-RPC) that has Cu-doped TiO2 films coated on stainless steel rotating disks, to experimentally evaluate the efficiency of the degradation and decolourization of methylene blue (MB) under irradiation from different light sources (visible 430 nm, LED 460 nm and LED 525 nm). The production of hydroxyl radicals is also examined. The experimental results show that the photocatalytic activity of TiO2 that is doped with Cu(2+)is induced by illumination with visible light and a LED...
July 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28737814/synthesis-and-characterization-of-1-diphenylphosphino-1-isocyanoferrocene-an-organometallic-ligand-combining-two-different-soft-donor-moieties-and-its-group-11-metal-complexes
#15
Karel Škoch, Ivana Císařová, Jiří Schulz, Ulrich Siemeling, Petr Štěpnička
The development of a practical synthesis of 1'-(diphenylphosphino)-1-aminoferrocene (2) and its P-borane adduct (2B) allowed the facile preparation of 1'-(diphenylphosphino)-1-isocyanoferrocene (1). This compound combining two specific soft-donor moieties was studied as a ligand for univalent Group 11 metal ions. The reactions of 1 with AgCl at 1 : 1 and 2 : 1 molar ratios only led to the coordination polymer [Ag2(μ-Cl)2(μ(P,C)-1)]n (6), while those with Ag[SbF6] provided the dimer [Ag2(Me2CO-κO)2(μ(P,C)-1)2][SbF6]2 and the quadruply-bridged disilver complex [Ag2(μ(P,C)-1)4][SbF6]2 (8), respectively...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28737800/c-h-addition-reactivity-of-2-phenylpyridine-and-2-2-bipyridine-with-pentaphenylborole
#16
Venkata A K Adiraju, Caleb D Martin
The reactions of pentaphenylborole with pyridines with a pendent aryl group in the 2-position, specifically 2-phenylpyridine and 2,2'-bipyridine, readily afforded adducts. Upon thermolysis, the adducts converted to ortho C-H addition products with the two substituents introduced onto the diene on the boracyclic carbon atoms adjacent to boron in a syn fashion. Photolysis of the syn 2-phenypyridine product led to isomerization to the anti conformer which did not readily occur for the 2,2'-bipyridine complex. Such C-H bond reactivity is uncommon for main group elements and provides insight into methodologies to access boron frameworks...
July 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28737753/metabolic-control-of-the-scaffold-protein-tks5-in-tissue-invasive-proinflammatory-t-cells
#17
Yi Shen, Zhenke Wen, Yinyin Li, Eric L Matteson, Jison Hong, Jörg J Goronzy, Cornelia M Weyand
Pathogenic T cells in individuals with rheumatoid arthritis (RA) infiltrate non-lymphoid tissue sites, maneuver through extracellular matrix and form lasting inflammatory microstructures. Here we found that RA T cells abundantly express the podosome scaffolding protein TKS5, which enables them to form tissue-invasive membrane structures. TKS5 overexpression was regulated by the intracellular metabolic environment of RA T cells-specifically, by reduced glycolytic flux that led to deficiencies in ATP and pyruvate...
July 24, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28737730/sildenafil-in-infants-and-children
#18
REVIEW
Larisa Simonca, Robert Tulloh
Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy. Sildenafil, a phosphodiesterase-V inhibitor, has been at the centre of this treatment, and its success in treating PAH has led to its widespread uptake in adult and paediatric pulmonary hypertension (PH), as a first line treatment choice. This might apply to persistent pulmonary hypertension of the newborn (PPHN) or bronchopulmonary dysplasia, as well as to more complex diseases, such as idiopathic pulmonary hypertension...
July 24, 2017: Children
https://www.readbyqxmd.com/read/28737703/autophagy-and-human-neurodegenerative-diseases-a-fly-s-perspective
#19
REVIEW
Myungjin Kim, Allison Ho, Jun Hee Lee
Neurodegenerative diseases in humans are frequently associated with prominent accumulation of toxic protein inclusions and defective organelles. Autophagy is a process of bulk lysosomal degradation that eliminates these harmful substances and maintains the subcellular environmental quality. In support of autophagy's importance in neuronal homeostasis, several genetic mutations that interfere with autophagic processes were found to be associated with familial neurodegenerative disorders. In addition, genetic mutations in autophagy-regulating genes provoked neurodegenerative phenotypes in animal models...
July 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28737636/reducing-length-of-stay-direct-cost-and-readmissions-in-total-joint-arthroplasty-patients-with-an-outcomes-manager-led-interprofessional-team
#20
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Orthopaedic Nursing
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