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https://www.readbyqxmd.com/read/27908678/avoidance-of-late-rectal-toxicity-after-high-dose-rate-brachytherapy-boost-treatment-for-prostate-cancer
#1
Borut Kragelj, Jernej Zlatic, Lijana Zaletel-Kragelj
PURPOSE: To elucidate potential risk factors important for the appearance of late rectal toxicity (LRT) after high-dose-rate boost treatment (HDRBT) of prostate cancer and to validate the predictive value of the minimal dose to the most exposed 2 cc of rectum received with HDRBT (D2ccrect). METHODS AND MATERIALS: The study of LRT, defined as relative deterioration of defecation problems (RDDP) (stool frequency, pain, rectal bleeding, fecal urgency, and incontinence) during follow-up period, was carried out on 88 patients, consecutively treated from October 2006 through April 2011 with HDRBT of 3 × 6-7 Gy to 50-50...
November 28, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27895686/successful-treatment-of-a-67-year-old-woman-with-urethral-adenocarcinoma-with-the-use-of-external-beam-radiotherapy-and-image-guided-adaptive-interstitial-brachytherapy
#2
Jasmin Mujkanovic, Kari Tanderup, Mads Agerbæk, Ulla Bisgaard, Søren Høyer, Jacob Christian Lindegaard, Lars Fokdal
Primary urethral cancer (PUC) is a very rare disease. This case report illustrates a successful treatment approach of a 67-year-old woman with a urethral adenocarcinoma selected for an organ preserving treatment with external beam radiotherapy (EBRT) and interstitial brachytherapy (BT) boost, using the GEC-ESTRO target concept originally designed for locally advanced cervical cancer (LACC). Treatment included EBRT with 45 Gy in 25 fractions followed by image guided adaptive interstitial BT (IGABT) with a pulsed-dose-rate (PDR) BT boost with 30 Gy in 50 hourly pulses...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27895683/salvage-interstitial-brachytherapy-based-on-computed-tomography-for-recurrent-cervical-cancer-after-radical-hysterectomy-and-adjuvant-radiation-therapy-case-presentations-and-introduction-of-the-technique
#3
Zhong-Shan Liu, Jie Guo, Yang-Zhi Zhao, Xia Lin, Bin Chen, Ming Zhang, Jiang-Ming Li, Xiao-Jun Ren, Bing-Ya Zhang, Tie-Jun Wang
PURPOSE: Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT). MATERIAL AND METHODS: Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant external-beam radiotherapy (EBRT) were included in this study. These patients underwent high-dose-rate (HDR) interstitial BT with free-hand placement of metal needles guided by real-time 3D-CT...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27895682/development-and-clinical-implementation-of-a-new-template-for-mri-based-intracavitary-interstitial-gynecologic-brachytherapy-for-locally-advanced-cervical-cancer-from-ct-based-mupit-to-the-mri-compatible-template-benidorm-ten-years-of-experience
#4
Silvia Rodríguez Villalba, Jose Richart Sancho, Antonio Otal Palacín, Jose Perez-Calatayud, Manuel Santos Ortega
PURPOSE: To study outcome and toxicity in 59 patients with locally advanced cervix carcinoma treated with computed tomography (CT)-based Martinez universal perineal interstitial template (MUPIT) and the new magnetic resonance imaging (MRI)-compatible template Benidorm (TB). MATERIAL AND METHODS: From December 2005 to October 2015, we retrospectively analyzed 34 patients treated with MUPIT and 25 treated with the TB. Six 4 Gy fractions were prescribed to the clinical target volume (CTV) combined with external beam radiotherapy (EBRT)...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27895681/rectal-separation-using-hydroxypropyl-methylcellulose-in-intracavitary-brachytherapy-of-cervical-cancer-an-innovative-approach
#5
Swapnendu Basu, Kazi Sazzad Manir, Abhishek Basu, Koushik Ghosh
PURPOSE: This study was initiated to prove feasibility of hydrogel application in recto-vaginal space in intracavitary brachytherapy (ICBT) of cervical cancer in order to reduce rectal toxicity. MATERIAL AND METHODS: In a case of stage IIB cervical cancer, after external beam radiotherapy (EBRT), we planned ICBT 7 Gy × 3 fractions. In 1(st) fraction (Plan 1), due to narrow separation between rectum and cervix (0.18 cm), only 5 Gy was delivered at point A (with high-risk clinical target volume [HR-CTV] D90 5...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27889184/gec-estro-acrop-recommendations-for-head-neck-brachytherapy-in-squamous-cell-carcinomas-1st-update-improvement-by-cross-sectional-imaging-based-treatment-planning-and-stepping-source-technology
#6
György Kovács, Rafael Martinez-Monge, Ashwini Budrukkar, Jose Luis Guinot, Bengt Johansson, Vratislav Strnad, Janusz Skowronek, Angeles Rovirosa, Frank-André Siebert
The Head and Neck Working Group of the GEC-ESTRO (Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology) published in 2009 the consensus recommendations for low-dose rate, pulsed-dose rate and high-dose rate brachytherapy in head & neck cancers. The use of brachytherapy in combination with external beam radiotherapy and/or surgery was also covered as well as the use of brachytherapy in previously irradiated patients. Given the developments in the field, these recommendations needed to be updated to reflect up-to-date knowledge...
November 23, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27882806/comorbidity-as-a-predictor-of-overall-survival-in-prostate-cancer-patients-treated-with-external-beam-radiotherapy-combined-with-hdr-brachytherapy-boosts
#7
Marie Hjälm-Eriksson, Anders Ullén, Hemming Johansson, Seymoure Levitt, Sten Nilsson, Karl-Mikael Kälkner
BACKGROUND: The risk stratification currently applied prior to curative treatment for localized prostate cancer (PC) does not take into account comorbidity or age. Therefore, we investigated the impact of comorbidity on overall survival (OS) in PC patients treated with external beam radiotherapy (EBRT) and high-dose rate (HDR) brachytherapy boost. MATERIAL AND METHODS: At a single center, 611 consecutive patients diagnosed with localized PC from 1998 to 2004 underwent definitive EBRT (50 Gy) and HDR brachytherapy boosts (2 × 10 Gy) combined with neoadjuvant total androgen blockade...
November 24, 2016: Acta Oncologica
https://www.readbyqxmd.com/read/27873241/predictive-factors-of-18-f-choline-pet-ct-positivity-in-patients-with-prostate-cancer-recurrence-after-radiation-therapy-is-the-impact-of-psa-nadir-underestimated
#8
Alison C Johnson, Audrey Emmanuelle Dugué, Marlon Silva, Laura Moise, Xavier Tillou, Florence Joly, Nicolas Aide
BACKGROUND: The objective of this study is to explore the impact of PSA nadirs on detection rates of prostate cancer (PCa) recurrence with (18)F-choline (CH) PET/CT after external beam radiation therapy (EBRT). METHODS: In this retrospective study, data were collected from 54 patients with suspicion of PCa biochemical recurrence after EBRT (28 patients treated initially with EBRT and 26 as salvage therapy in the absence of PSA decrease after initial treatment), who underwent (18)F-CH PET/CT between 2010 and 2015...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27866953/triple-tandem-high-dose-rate-brachytherapy-for-early-stage-medically-inoperable-endometrial-cancer-initial-report-on-acute-toxicity-and-dosimetric-comparison-to-stereotactic-body-radiation-therapy
#9
Greg Kauffmann, Tianming Wu, Hania Al-Hallaq, Yasmin Hasan
PURPOSE: Stereotactic body radiotherapy (SBRT) may be appealing in medically inoperable endometrial cancer to avoid procedural risks. We performed a dosimetric comparison to triple-tandem, high-dose-rate (HDR) brachytherapy. METHODS AND MATERIALS: Six consecutive clinical stage I, grade 1-2, medically inoperable endometrial cancer patients were treated with triple-tandem HDR brachytherapy. We report patient factors and acute toxicity. Also, we performed dosimetric comparison to SBRT using both 3D conformal arc (3DArc) and volumetric-modulated arc therapy...
November 17, 2016: Brachytherapy
https://www.readbyqxmd.com/read/27858093/targeted-intraoperative-radiotherapy-tumour-bed-boost-during-breast-conserving-surgery-after-neoadjuvant-chemotherapy
#10
Hans-Christian Kolberg, Gyoergy Loevey, Leyla Akpolat-Basci, Miltiades Stephanou, Peter A Fasching, Michael Untch, Cornelia Liedtke, Max Bulsara, Jayant S Vaidya
INTRODUCTION: The use of targeted intraoperative radiotherapy (TARGIT-IORT) as a tumour bed boost during breast-conserving surgery (BCS) for breast cancer has been reported since 1998. We present its use in patients undergoing breast conservation following neoadjuvant therapy (NACT). METHOD: In this retrospective study involving 116 patients after NACT we compared outcomes of 61 patients who received a tumour bed boost with IORT during lumpectomy versus 55 patients treated in the previous 13 months with external (EBRT) boost...
November 17, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27853900/risk-factors-leading-to-complications-in-early-stage-breast-cancer-following-breast-conserving-surgery-and-intraoperative-radiotherapy
#11
Sunpreet Rakhra, Kevin Bethke, Jonathan Strauss, John P Hayes, Nora Hansen, Seema A Khan, Irene Helenowski, Eric D Donnelly
OBJECTIVE: The aim of this study was to evaluate outcomes after breast-conserving surgery (BCS) and intraoperative radiotherapy (IORT), and to identify risk factors associated with complications. MATERIALS/METHODS: We evaluated patients with early-stage breast cancer treated from January 1, 2011 to January 31, 2014 with BCS and IORT at a single institution. The presence of breast cancer recurrences, complications, or fat necrosis were assessed at subsequent follow-up visits using physical examination and breast imaging...
November 16, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27842672/can-multiparametric-mri-replace-roach-equations-in-staging-prostate-cancer-before-external-beam-radiation-therapy
#12
Rossano Girometti, Marco Andrea Signor, Martina Pancot, Lorenzo Cereser, Chiara Zuiani
PURPOSE: To investigate the agreement between Roach equations (RE) and multiparametric magnetic resonance imaging (mpMRI) in assessing the T-stage of prostate cancer (PCa). MATERIALS AND METHODS: Seventy-three patients with biopsy-proven PCa and previous RE assessment prospectively underwent mpMRI on a 3.0T magnet before external beam radiation therapy (EBRT). Using Cohen's kappa statistic, we assessed the agreement between RE and mpMRI in defining the T-stage (≥T3 vs...
December 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27837208/low-dose-external-beam-radiotherapy-for-greater-trochanteric-pain-syndrome-target-volume-definition-and-treatment-outcome
#13
Alexander Kaltenborn, Ulrich Martin Carl, Tanja Hinsche, Mirko Nitsche, Robert Michael Hermann
PURPOSE: Low-dose external beam radiotherapy (ED-EBRT) is frequently used in the therapy of refractory greater trochanteric pain syndrome (GTPS). As studies reporting treatment results are scarce, we retrospectively analyzed our own patient collectives. PATIENTS AND METHODS: In all, 60 patients (74 hips) received LD-EBRT (6 × 0.5 Gy in 29 hips, 6 × 1 Gy in 45). The endpoint was the patient's reported subjective response to treatment. The influence of different patient and treatment characteristics on treatment outcome was investigated...
November 11, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27834929/prostate-specific-antigen-psa-as-predicting-marker-for-clinical-outcome-and-evaluation-of-early-toxicity-rate-after-high-dose-rate-brachytherapy-hdr-bt-in-combination-with-additional-external-beam-radiation-therapy-ebrt-for-high-risk-prostate-cancer
#14
Thorsten H Ecke, Hui-Juan Huang-Tiel, Klaus Golka, Silvia Selinski, Berit Christine Geis, Stephan Koswig, Katrin Bathe, Steffen Hallmann, Holger Gerullis
High-dose-rate brachytherapy (HDR-BT) with external beam radiation therapy (EBRT) is a common treatment option for locally advanced prostate cancer (PCa). Seventy-nine male patients (median age 71 years, range 50 to 79) with high-risk PCa underwent HDR-BT following EBRT between December 2009 and January 2016 with a median follow-up of 21 months. HDR-BT was administered in two treatment sessions (one week interval) with 9 Gy per fraction using a planning system and the Ir192 treatment unit GammaMed Plus iX. EBRT was performed with CT-based 3D-conformal treatment planning with a total dose administration of 50...
November 10, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27829431/radiomics-based-targeted-radiotherapy-planning-rad-trap-a-computational-framework-for-prostate-cancer-treatment-planning-with-mri
#15
Rakesh Shiradkar, Tarun K Podder, Ahmad Algohary, Satish Viswanath, Rodney J Ellis, Anant Madabhushi
BACKGROUND: Radiomics or computer - extracted texture features have been shown to achieve superior performance than multiparametric MRI (mpMRI) signal intensities alone in targeting prostate cancer (PCa) lesions. Radiomics along with deformable co-registration tools can be used to develop a framework to generate targeted focal radiotherapy treatment plans. METHODS: The Rad-TRaP framework comprises three distinct modules. Firstly, a module for radiomics based detection of PCa lesions on mpMRI via a feature enabled machine learning classifier...
November 10, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27825903/radiosurgery-for-paragangliomas-of-the-head-and-neck-another-step-for-the-validation-of-a-treatment-paradigm
#16
Marcello Marchetti, Valentina Pinzi, Irene Tramacere, Livia Corinna Bianchi, Francesco Ghielmetti, Laura Fariselli
BACKGROUND: Paragangliomas are highly vascular and predominantly benign neoplasms that have traditionally been treated by surgery, embolization and/or external beam radiotherapy (EBRT). The aim of this study is to evaluate long-term local tumor control and safety of radiosurgery for the head and neck paragangliomas. METHODS: Data were obtained from prospectively maintained databases of patients affected by brain tumors treated with radiosurgery at our institution...
November 4, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27825386/initial-results-for-patient-setup-verification-using-transperineal-ultrasound-and-cone-beam-ct-in-external-beam-radiation-therapy-of-prostate-cancer
#17
Anne Richter, Bülent Polat, Ingulf Lawrenz, Stefan Weick, Otto Sauer, Michael Flentje, Frederick Mantel
BACKGROUND: Evaluation of set up error detection by a transperineal ultrasound in comparison with a cone beam CT (CBCT) based system in external beam radiation therapy (EBRT) of prostate cancer. METHODS: Setup verification was performed with transperineal ultrasound (TPUS) and CBCT for 10 patients treated with EBRT for prostate cancer. In total, 150 ultrasound and CBCT scans were acquired in rapid succession and analyzed for setup errors. The deviation between setup errors of the two modalities was evaluated separately for each dimension...
November 8, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27823769/patterns-of-adjuvant-radiation-usage-and-survival-outcomes-for-stage-i-endometrial-carcinoma-in-a-large-hospital-based-cohort
#18
Andrew T Wong, Justin Rineer, David Schwartz, Joseph Weiner, Joseph Safdieh, Kwang Choi, David Schreiber
OBJECTIVE: Two randomized trials have demonstrated a local control advantage in the absence of a survival advantage for the addition of adjuvant radiation therapy (RT) to surgery in patients with stage I endometrial adenocarcinoma (EC). This study analyzed the National Cancer Data Base (NCDB) to evaluate the impact of adjuvant RT on overall survival (OS) for patients with stage I EC. METHODS: Patients with EC who underwent total hysterectomy/bilateral salpingo-oophorectomy between 2004 and 2011 were queried...
November 4, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27819877/benefit-of-radiotherapy-in-extraskeletal-myxoid-chondrosarcoma-a-propensity-score-weighted-population-based-analysis-of-the-seer-database
#19
Eric J Kemmerer, Elizabeth Gleeson, Jaganmohan Poli, Robert T Ownbey, Luther W Brady, Wilbur B Bowne
OBJECTIVES: Extraskeletal myxoid chondrosarcoma (EMC) is a rare malignancy for which the role of radiotherapy is not well-defined. We examine the effect of external beam radiotherapy (EBRT) on cancer-specific survival (CSS) for patients with localized EMC, in a propensity score weighted, population-based analysis. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results database (1973 to 2012) was queried for cases of localized EMC arising from soft connective tissues of the trunk and extremities treated with surgery and/or EBRT...
November 4, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27799048/prostate-external-beam-radiotherapy-combined-with-high-dose-rate-brachytherapy-dose-volume-parameters-from-deformably-registered-plans-correlate-with-late-gastrointestinal-complications
#20
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
BACKGROUND: Derivation of dose-volume correlated with toxicity for multi-modal treatments can be difficult due to the perceived need for voxel-by-voxel dose accumulation. With data available for a single-institution cohort with long follow-up, an investigation was undertaken into rectal dose-volume effects for gastrointestinal toxicities after deformably-registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR) brachytherapy prostate treatment. METHODS: One hundred and eighteen patients received EBRT in 23 fractions of 2 Gy and HDR (TG43 algorithm) in 3 fractions of 6...
October 31, 2016: Radiation Oncology
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