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https://www.readbyqxmd.com/read/28324093/association-between-radiation-therapy-surgery-or-observation-for-localized-prostate-cancer-and-patient-reported-outcomes-after-3-years
#1
Daniel A Barocas, JoAnn Alvarez, Matthew J Resnick, Tatsuki Koyama, Karen E Hoffman, Mark D Tyson, Ralph Conwill, Dan McCollum, Matthew R Cooperberg, Michael Goodman, Sheldon Greenfield, Ann S Hamilton, Mia Hashibe, Sherrie H Kaplan, Lisa E Paddock, Antoinette M Stroup, Xiao-Cheng Wu, David F Penson
Importance: Understanding the adverse effects of contemporary approaches to localized prostate cancer treatment could inform shared decision making. Objective: To compare functional outcomes and adverse effects associated with radical prostatectomy, external beam radiation therapy (EBRT), and active surveillance. Design, Setting, and Participants: Prospective, population-based, cohort study involving 2550 men (≤80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with prostate-specific antigen levels less than 50 ng/mL, and enrolled within 6 months of diagnosis...
March 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28297345/a-software-tool-to-automatically-assure-and-report-daily-treatment-deliveries-by-a-cobalt-60-radiation-therapy-device
#2
Deshan Yang, H Omar Wooten, Olga Green, Harold H Li, Shi Liu, Xiaoling Li, Vivian Rodriguez, Sasa Mutic, Rojano Kashani
The aims of this study were to develop a method for automatic and immediate verification of treatment delivery after each treatment fraction in order to detect and correct errors, and to develop a comprehensive daily report which includes delivery verification results, daily image-guided radiation therapy (IGRT) review, and information for weekly physics reviews. After systematically analyzing the requirements for treatment delivery verification and understanding the available information from a commercial MRI-guided radiotherapy treatment machine, we designed a procedure to use 1) treatment plan files, 2) delivery log files, and 3) beam output information to verify the accuracy and completeness of each daily treatment delivery...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28287519/endobronchial-ultrasound-guided-intratumoral-injection-of-cisplatin-for-the-treatment-of-isolated-mediastinal-recurrence-of-lung-cancer
#3
Hiren J Mehta, Michael A Jantz
Isolated hilar and mediastinal recurrence (IMHR) following external beam radiation therapy (EBRT) in patients with lung cancer is common. These patients do not have many treatment options and are usually offered palliative chemotherapy or best supportive care. Endobronchial ultrasound (EBUS)-guided intratumoral injection of cisplatin (ITC) is a novel approach for these patients. The procedure is performed under conscious sedation. The lesion is located with a bronchoscopy using EBUS, and a 22-gauge EBUS needle is advanced through the working channel of the scope and locked in position...
February 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28284642/microbial-community-changes-during-different-empty-bed-residence-times-and-operational-fluctuations-in-an-air-diffusion-reactor-for-odor-abatement
#4
Elisa Rodríguez, Pedro A García-Encina, Raúl Muñoz, Raquel Lebrero
The succession of bacterial and fungal populations was assessed in an activated sludge (AS) diffusion bioreactor treating a synthetic malodorous emission containing H2S, toluene, butanone and alpha-pinene. Microbial community characteristics (bacterial and fungal diversity, richness, evenness and composition) and bioreactor function relationships were evaluated at different empty bed residence times (EBRTs) and after process fluctuations and operational failures (robustness test). For H2S, butanone and toluene, the bioreactor showed a stable and efficient abatement performance regardless of the EBRT and fluctuations applied, while low alpha-pinene removals were observed...
March 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28284493/dosimetric-impact-of-contouring-and-needle-reconstruction-uncertainties-in-us-ct-and-mri-based-high-dose-rate-prostate-brachytherapy-treatment-planning
#5
Susanne Rylander, Simon Buus, Erik M Pedersen, Lise Bentzen, Kari Tanderup
BACKGROUND AND PURPOSE: The purpose was to evaluate the dosimetric impact of target contouring and needle reconstruction uncertainties in an US-, CT- and MRI-based HDR prostate BT treatment planning. MATERIAL AND METHODS: US, CT, and MR images were acquired post-needle insertion in 22 HDR-BT procedures for 11 consecutive patients. Dose plans were simulated for an US-, CT- and MRI-based HDR-BT treatment planning procedure. Planning uncertainties in US- and CT-based plans were evaluated using MRI-based planning as reference...
March 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28283977/removal-of-traces-of-toluene-and-p-xylene-in-indoor-air-using-biofiltration-and-a-hybrid-system-biofiltration-adsorption
#6
Angela Tatiana Luengas, Cécile Hort, Vincent Platel, Ana Elias, Astrid Barona, Laurent Moynault
Biofiltration technology and the hybrid system combining biofiltration and adsorption (onto activated carbon) were compared as possible methods to toluene and p-xylene at parts per million concentration levels (2-45 and 1-33 ppb, respectively). An organic material was used as packing material for the biofiltration process. Even at low empty bed residence times (EBRTs) and concentrations, toluene removal efficiency reached 100% and p-xylene showed an increasing trend on their removal efficiency over the time using biofiltration...
March 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28280622/high-dose-chemoradiation-for-unresectable-hilar-cholangiocarcinomas-using-intensity-modulated-external-beam-radiotherapy-a-single-tertiary-care-centre-experience
#7
Reena Engineer, Shaesta Mehta, Nikhil Kalyani, Suresh Chaudhari, Tejas Dharia, Nitin Shetty, Supriya Chopra, Mahesh Goel, Suyash Kulkarni, Shyam Kishore Shrivastava
BACKGROUND: We present results of patients diagnosed with unresectable hilar cholangiocarcinomas treated with high dose radiotherapy and concurrent chemotherapy. METHODS: From Aug 2005 to Dec 2012, 68 consecutive patients were treated. Fifty patients (group 1) presenting to us with obstructive jaundice were planned for endobiliary brachytherapy (EBBT 14 Gy) followed external beam radiotherapy (EBRT 45 Gy). Twenty-two patients (group 2) who had previously undergone biliary drainage underwent EBRT (57 Gy)...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28280621/inflammatory-bowel-diseases-activity-in-patients-undergoing-pelvic-radiation-therapy
#8
Pierre Annede, Thomas Seisen, Caroline Klotz, Renaud Mazeron, Pierre Maroun, Claire Petit, Eric Deutsch, Alberto Bossi, Christine Haie-Meder, Cyrus Chargari, Pierre Blanchard
BACKGROUND: Few studies with contradictory results have been published on the safety of pelvic radiation therapy (RT) in patients with inflammatory bowel disease (IBD). METHODS: From 1989 to 2015, a single center retrospective analysis was performed including all IBD patients who received pelvic external beam radiation therapy (EBRT) or brachytherapy (BT) for a pelvic malignancy. Treatment characteristics, IBD activity and gastrointestinal (GI) toxicity were examined...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28270011/magnetic-resonance-only-simulation-and-dose-calculation-in-external-beam-radiation-therapy-a-feasibility-study-for-pelvic-cancers
#9
Reko Kemppainen, Sami Suilamo, Terhi Tuokkola, Paula Lindholm, Martin H Deppe, Jani Keyriläinen
BACKGROUND: The clinical feasibility of using pseudo-computed tomography (pCT) images derived from magnetic resonance (MR) images for external bean radiation therapy (EBRT) planning for prostate cancer patients has been well demonstrated. This paper investigates the feasibility of applying an MR-derived, pCT planning approach to additional types of cancer in the pelvis. MATERIAL AND METHODS: Fifteen patients (five prostate cancer patients, five rectal cancer patients, and five gynecological cancer patients) receiving EBRT at Turku University Hospital (Turku, Finland) were included in the study...
March 8, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28266225/stereotactic-radiosurgery-and-stereotactic-fractionated-radiotherapy-for-metastatic-tumors-of-the-spine
#10
Juan Manuel L Mariano, Erickson F Torio, Ma Socorro S D Santos, Ibet Marie Y Sih, Roy Allan Dominique G Torcuator
OBJECTIVES: The objectives of this paper are to describe pain control, neurologic improvement, local tumor control, progression-free survival, and overall survival of spine SRS/SFRT patients, and to compare our outcomes with other studies on spine stereotactic radiotherapy for metastatic tumors. METHODS: A chart review of patients who underwent spine SRS/SFRT was done. Information was collected on patient age, sex, histology, site treated, pain relief, local control, neurologic function, prescription dose, and complications...
March 7, 2017: Neurological Research
https://www.readbyqxmd.com/read/28263132/the-need-for-androgen-deprivation-therapy-in-patients-with-intermediate-risk-prostate-cancer-treated-with-dose-escalated-external-beam-radiation-therapy
#11
Yanqun Dong, Karen J Ruth, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Y T Chen, Robert G Uzzo, Mark H Hallman, Eric M Horwitz
INTRODUCTION: To evaluate if androgen deprivation therapy (ADT) improves outcomes for patients with localized, intermediate-risk prostate cancer treated with definitive external beam radiation therapy (EBRT) in the dose-escalated era. MATERIALS AND METHODS: This is a retrospective study using a single institutional database. We included patients with localized, intermediate-risk prostate cancer treated with dose-escalated radiation therapy (RT) with 3D conformal radiotherapy or intensity-modulated radiotherapy (74-80 Gy in daily fraction of 1...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28262473/androgen-suppression-combined-with-elective-nodal-and-dose-escalated-radiation-therapy-the-ascende-rt-trial-an-analysis-of-survival-endpoints-for-a-randomized-trial-comparing-a%C3%A2-low-dose-rate-brachytherapy-boost-to-a%C3%A2-dose-escalated-external-beam-boost-for
#12
W James Morris, Scott Tyldesley, Sree Rodda, Ross Halperin, Howard Pai, Michael McKenzie, Graeme Duncan, Gerard Morton, Jeremy Hamm, Nevin Murray
PURPOSE: To report the primary endpoint of biochemical progression-free survival (b-PFS) and secondary survival endpoints from ASCENDE-RT, a randomized trial comparing 2 methods of dose escalation for intermediate- and high-risk prostate cancer. METHODS AND MATERIALS: ASCENDE-RT enrolled 398 men, with a median age of 68 years; 69% (n=276) had high-risk disease. After stratification by risk group, the subjects were randomized to a standard arm with 12 months of androgen deprivation therapy, pelvic irradiation to 46 Gy, followed by a dose-escalated external beam radiation therapy (DE-EBRT) boost to 78 Gy, or an experimental arm that substituted a low-dose-rate prostate brachytherapy (LDR-PB) boost...
November 24, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28258954/prevalence-and-predicting-factors-for-commonly-neglected-sexual-side-effects-to-external-beam-radiation-therapy-for-prostate-cancer
#13
Anders Frey, Christian Pedersen, Henriette Lindberg, Rasmus Bisbjerg, Jens Sønksen, Mikkel Fode
INTRODUCTION: Changes in sexual function other than erectile dysfunction are sparsely investigated after radiation therapy for prostate cancer. AIM: To investigate orgasmic dysfunction, urinary incontinence during sexual activity, changes in penile morphology, and sensory disturbances in the penis in patients with prostate cancer treated with external-beam radiation therapy (EBRT). METHODS: In February 2015, men treated with EBRT at our center 3 months to 5 years previously (N = 519) received a study-specific questionnaire...
February 28, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28255431/helical-tomotherapy-for-duodenal-adenocarcinoma-in-an-elderly-patient-a-case-report
#14
Valentina Lancellotta, Giuseppe Russo, Marco Lupattelli, Martina Iacco, Elisabetta Perrucci, Claudio Zucchetti, Lorenzo Falcinelli, Cynthia Aristei
To evaluate the efficacy and feasibility of external beam radiotherapy (EBRT) for duodenal adenocarcinoma in an 84-year-old female who underwent EBRT (2.2 Gy/d for a total dose of 46.2 Gy) using helical tomotherapy (HT). Toxicity was evaluated on the National Cancer Institute's common toxicity criteria (CTCAE 3.0). The patient completed the treatment without G3-G4 toxicity. After 22-mo follow-up, she is alive and well, in complete remission with no late side effects. HT seems to be feasible and effective for duodenal adenocarcinoma in old to very old patients...
February 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28255386/variation-in-uterus-position-prior-to-brachytherapy-of-the-cervix-a-case-report
#15
M T Georgescu, R Anghel
Rationale: brachytherapy is administered in the treatment of patients with locally advanced cervical cancer following chemoradiotherapy. Lack of local anatomy evaluation prior to this procedure might lead to the selection of an inappropriate brachytherapy applicator, increasing the risk of side effects (e.g. uterus perforation, painful procedure ...). Objective: To assess the movement of the uterus and cervix prior to brachytherapy in patients with gynecological cancer, in order to select the proper type of brachytherapy applicator...
January 2017: Journal of Medicine and Life
https://www.readbyqxmd.com/read/28252805/postoperative-complications-following-intraoperative-radiotherapy-in-abdominopelvic-malignancy-a-single-institution-analysis-of-113-consecutive-patients
#16
Eihab Abdelfatah, Andrew Page, Justin Sacks, Phillip Pierorazio, Trinity Bivalacqua, Jonathan Efron, Stephanie Terezakis, Susan Gearhart, Sandy Fang, Bashar Safar, Timothy M Pawlik, Elwood Armour, Amy Hacker-Prietz, Joseph Herman, Nita Ahuja
BACKGROUND: Intraoperative radiotherapy (IORT) has advantages over external beam radiation therapy (EBRT). Few studies have described side effects associated with its addition. We evaluated our institution's experience with abdominopelvic IORT to assess safety by postoperative complication rates. METHODS: Prospectively collected IRB-approved database of all patients receiving abdominopelvic IORT (via high dose rate brachytherapy) at Johns Hopkins Hospital between November 2006 and May 2014 was reviewed...
March 2, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28237165/treatment-of-choice-for-patients-with-egfr-mutation-positive-non-small-cell-lung-carcinoma-presenting-with-choroidal-metastases-radiotherapy-or-tkis
#17
David Maskell, Konstantinos Geropantas, Michael Kouroupis, Andrew Glenn, Thankamma Ajithkumar
INTRODUCTION: It is not uncommon for patients with non-small cell lung cancer (NSCLC) to develop choroidal metastases (CM). External beam radiotherapy (EBRT) has traditionally been considered the treatment of choice for CM as it offers high response rates and quick relief of symptoms. However, new targeted treatments can offer an effective, alternative treatment strategy for patients harbouring specific genetic abnormalities. CASE STUDY: We present the case of a patient presenting with a symptomatic metastasis to the choroid from an epidermal growth factor receptor (EGFR) mutation-positive NSCLC and exhibiting an excellent clinical and radiological response to the tyrosine kinase inhibitor (TKI) gefitinib...
February 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28229172/external-beam-radiation-therapy-combined-with-limb-sparing-surgery-in-elderly-patients-70%C3%A2-years-with-primary-soft-tissue-sarcomas-of-the-extremities-a%C3%A2-retrospective-analysis
#18
Claudia Andrä, Alexander Klein, Hans Roland Dürr, Josefine Rauch, Lars Hartwin Lindner, Thomas Knoesel, Martin Angele, Andrea Baur-Melnyk, Claus Belka, Falk Roeder
PURPOSE: To report our experience with EBRT combined with limb-sparing surgery in elderly patients (>70 years) with primary extremity soft tissue sarcomas (STS). METHODS: Retrospectively analyzed were 35 patients (m:f 18:17, median 78 years) who all presented in primary situation without nodal/distant metastases (Charlson score 0/1 in 18 patients; ≥2 in 17 patients). Median tumor size was 10 cm, mainly located in lower limb (83%). Stage at presentation (UICC7th) was Ib:3%, 2a:20%, 2b:20%, and 3:57%...
February 22, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28214368/evaluation-of-deformable-image-registration-between-external-beam-radiotherapy-and-hdr-brachytherapy-for-cervical-cancer-with-a-3d-printed-deformable-pelvis-phantom
#19
Noriyuki Kadoya, Yuya Miyasaka, Yujiro Nakajima, Yoshihiro Kuroda, Kengo Ito, Mizuki Chiba, Kiyokazu Sato, Suguru Dobashi, Takaya Yamamoto, Noriyoshi Takahashi, Masaki Kubozono, Ken Takeda, Keiichi Jingu
PURPOSE: In this study, we developed a 3D-printed deformable pelvis phantom for evaluating spatial DIR accuracy. We then evaluated the spatial DIR accuracies of various DIR settings for cervical cancer. METHODS: A deformable female pelvis phantom was created based on patient CT data using 3D printing. To create the deformable uterus phantom, we first 3D printed both a model of uterus and a model of the internal cavities of the vagina and uterus. We then made a mold using the 3D printed uterus phantom...
February 18, 2017: Medical Physics
https://www.readbyqxmd.com/read/28214281/patient-characterization-and-usage-trends-of-proton-beam-therapy-for-localized-prostate-cancer-in-the-united-states-a-study-of-the-national-cancer-database
#20
Arya Amini, David Raben, E David Crawford, Thomas W Flaig, Elizabeth R Kessler, Elaine T Lam, Paul Maroni, Thomas J Pugh
PURPOSE: To evaluate usage trends and identify factors associated with proton beam therapy (PBT) compared to alternative forms of external beam radiation therapy (RT) (EBRT) for localized prostate cancer. PATIENTS AND METHODS: The National Cancer Database was queried for men with localized (N0, M0) prostate cancer diagnosed between 2004 and 2013, treated with EBRT, with available data on EBRT modality (photon vs. PBT). Binary multiple logistic regression identified variables associated with EBRT modality...
February 14, 2017: Urologic Oncology
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