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https://www.readbyqxmd.com/read/28717856/intraoperative-radiotherapy-for-extremity-soft-tissue-sarcomas-can-long-term-local-control-be-achieved
#1
Esther Carbó-Laso, Pablo Sanz-Ruiz, José Antonio Calvo-Haro, Miguel Cuervo-Dehesa, Rubén Pérez-Mañanes, Lydia Mediavilla-Santos, Coral Sánchez-Pérez, Ana Álvarez-González, Javier Vaquero-Martín
BACKGROUND: Intraoperative electron-beam radiation therapy (IOERT) during limb-sparing surgery has the advantage of delivering a single high boost dose to sarcoma residues and surgical bed area near to radiosensitive structures with limited toxicity. Retrospective studies have suggested that IOERT may improve local control compared to standard radiotherapy and we aimed to demonstrate this theory. Therefore, we performed an observational prospective study to determine (1) if it is possible to achieve high local control by adding IOERT to external-beam radiation therapy (EBRT) in extremity soft-tissue sarcomas (STS), (2) if it is possible to improve long-term survival rates, and (3) if toxicity could be reduced with IOERT MATERIALS AND METHODS: From 1995-2003, 39 patients with extremity STS were treated with IOERT and postoperative radiotherapy...
July 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28717396/intraoperative-radiotherapy-review-of-techniques-and-results
#2
REVIEW
Avinash Pilar, Meetakshi Gupta, Sarbani Ghosh Laskar, Siddhartha Laskar
Intraoperative radiotherapy (IORT) is a technique that involves precise delivery of a large dose of ionising radiation to the tumour or tumour bed during surgery. Direct visualisation of the tumour bed and ability to space out the normal tissues from the tumour bed allows maximisation of the dose to the tumour while minimising the dose to normal tissues. This results in an improved therapeutic ratio with IORT. Although it was introduced in the 1960s, it has seen a resurgence of popularity with the introduction of self-shielding mobile linear accelerators and low-kV IORT devices, which by eliminating the logistical issues of transport of the patient during surgery for radiotherapy or building a shielded operating room, has enabled its wider use in the community...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28712279/the-role-of-adjuvant-external-beam-radiation-therapy-for-papillary-thyroid-carcinoma-invading-the-trachea
#3
Young Suk Kim, Jae Hyuck Choi, Kwang Sik Kim, Gil Chae Lim, Jeong Hong Kim, Ju Wan Kang, Hee-Sung Song, Sang Ah Lee, Chang Lim Hyun, Yunseon Choi, Gwi Eon Kim
PURPOSE: To evaluate the effect of adjuvant external beam radiation therapy (EBRT) on local failure-free survival rate (LFFS) for papillary thyroid cancer (PTC) invading the trachea. MATERIALS AND METHODS: Fifty-six patients with locally advanced PTC invading the trachea were treated with surgical resection. After surgery, 21 patients received adjuvant EBRT and radioactive iodine therapy (EBRT group) and 35 patients were treated with radioactive iodine therapy (control group)...
June 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/28710895/erectile-function-after-stereotactic-body-radiotherapy-for-localized-prostate-cancer
#4
Robert T Dess, Holly E Hartman, Nima Aghdam, William C Jackson, Payal D Soni, Ahmed E Abugharib, Simeng Suy, Neil B Desai, Zachary S Zumsteg, Rohit Mehra, Todd M Morgan, Felix Y Feng, Daniel A Hamstra, Matthew J Schipper, Sean P Collins, Daniel E Spratt
OBJECTIVE: To elucidate the functional erection rate following prostate stereotactic body radiotherapy (SBRT) and to develop a comprehensive prognostic model of outcomes following treatment. PATIENTS AND METHODS: Between 2008 and 2013, 373 consecutive men with localized prostate cancer were treated with SBRT at a single academic institution as part of a prospective clinical trial or prospective registry. Prospective longitudinal patient-reported quality of life (HRQOL) was collected using the Expanded Prostate Cancer Index Composite (EPIC-26)...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28708929/stereotactic-body-radiotherapy-for-unresected-pancreatic-cancer-a-nationwide-review
#5
Susanna W L de Geus, Mariam F Eskander, Gyulnara G Kasumova, Sing Chau Ng, Tara S Kent, Joseph D Mancias, Mark P Callery, Anand Mahadevan, Jennifer F Tseng
BACKGROUND: The role of conventional radiotherapy in the management of pancreatic cancer has yet to be elucidated. Over the past decade, stereotactic body radiotherapy (SBRT) has emerged as a novel therapeutic option in pancreatic cancer care. This study evaluated the survival impact of SBRT on patients with unresected pancreatic cancer. METHODS: The National Cancer Data Base was queried for unresected patients who received chemotherapy for nonmetastatic pancreatic adenocarcinoma between 2004 and 2012...
July 14, 2017: Cancer
https://www.readbyqxmd.com/read/28699351/ultrahypofractionated-cyberknifetm-based-stereotactic-radiotherapy-versus-conventional-radiotherapy-in-patients-with-prostate-cancer-acute-toxicity-evaluation-in-two-phase-ii-prospective-studies
#6
G Głowacki, W Majewski, P Wojcieszek, K Grabinska, G Wozniak, L Miszczyk
Our purpose was to compare the acute toxicity of ultrahypofractionated CyberKnifeTM based stereotactic radiotherapy (SBRT Arm) and conventional radiotherapy (EBRT Arm) in prostate cancer patients. Two-hundred-sixteen men with prostate cancer were enrolled in our prospective studies. One-hundred and nine were irradiated using CyberKnife to total dose of 36,25 Gy in 5 fractions. One-hundred and seven were irradiated conventionally to total dose of 76 Gy in 38 fractions. Mean age of patients was 69. Acute genitourinary (GU) and gastrointestinal (GI) adverse-events were collected...
2017: Neoplasma
https://www.readbyqxmd.com/read/28695317/pre-radiotherapy-psa-progression-is-a%C3%A2-negative-prognostic-factor-in-prostate-cancer-patients-using-5%C3%A2-alpha-reductase-inhibitors
#7
Daniel Taussky, Julie Piotte, Kevin C Zorn, Marc Zanaty, Vimal Krishnan, Carole Lambert, Jean-Paul Bahary, Marie-Claude Beauchemin, Maroie Barkati, Cynthia Ménard, Guila Delouya
OBJECTIVE: To investigate the impact of 5‑alpha-reductase inhibitor (5-ARI) use on radiotherapy outcomes for localized prostate cancer. PATIENTS AND METHODS: We included 203 patients on a 5-ARI from our institutional database comprising over 2500 patients who had been treated with either external beam radiotherapy (EBRT) or brachytherapy for localized prostate cancer. Patients received a 5-ARI for urinary symptoms or active surveillance. Cancer progressions at the time of definitive treatment were analyzed according to the following criteria: (a) progression of Gleason score or increase in cancer volume on biopsy, (b) first biopsy positive for cancer after being treated for urinary symptoms with a 5-ARI, and (c) prostate-specific antigen (PSA) progression with or without a previous cancer diagnosis...
July 10, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28694116/effect-of-bladder-distension-on-doses-to-organs-at-risk-in-pulsed-dose-rate-3d-image-guided-adaptive-brachytherapy-for-locally-advanced-cervical-cancer
#8
Jean Philippe Nesseler, Claire Charra-Brunaud, Julia Salleron, Jean François Py, Andres Huertas, Emilie Meknaci, Florent Courrech, Didier Peiffert, Sophie Renard-Oldrini
PURPOSE: To evaluate the impact of bladder distension on doses to organs at risk in patients treated with 3D image-guided adaptive pulsed-dose-rate (PDR) brachytherapy (BT) for locally advanced cervical cancer. METHODS AND MATERIALS: Twenty-two patients who had previously been treated by external beam radiation therapy (EBRT), underwent BT treatment planning to a pelvic MRI (or a CT scan in case of contraindication) after their bladder was filled with 100 cc of physiological saline (full bladder)...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28694115/differences-in-urethral-dosimetry-between-ct-and-mr-imaging-in-multichannel-vaginal-cylinder-brachytherapy
#9
Katherine S Chen, Scott M Glaser, Hayeon Kim, Sushil Beriwal
PURPOSE: In image-based brachytherapy (IBBT), the dosimetry of small structures may be particularly sensitive to changes in contouring between imaging modalities. We therefore sought to characterize differences in urethral dosimetry in vaginal brachytherapy based on contouring on MRI vs. CT. METHODS AND MATERIALS: We retrospectively identified our most recent 15 patients treated with intracavitary brachytherapy for distal vaginal malignancies. On T2-weighted MRI, both the lumen and urethral wall were contoured...
July 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28693186/cholangiocarcinoma-following-external-beam-radiotherapy-a-report-of-two-cases
#10
Anisha Kulkarni, Justin S Gundara, Anthony J Gill, Thomas J Hugh, Jaswinder S Samra
Cholangiocarcinoma (CCA) is a relatively rare primary malignancy, with established risk factors that include primary sclerosing cholangitis, choledochal cysts and hepatolithiasis. In the present study, two cases of CCA, which occurred following abdominal external beam radiotherapy (EBRT) for non-Hodgkin's lymphoma, are reported. Case 1 and 2 were diagnosed with cholangiocarcinoma 30 and 4 years following treatment with combined chemotherapy and abdominal radiotherapy treatment, respectively. The patients received chemotherapy as treatment of cholangiocarcinoma; however, whilst their symptoms improved, they succumbed within 12 and 2 months respectively following the diagnosis with cholangiocarcinoma...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28693078/-effect-on-cryoablation-of-high-risk-and-locally-recurrent-prostate-cancer-a-meta-analysis
#11
X Liang, X L Yang, Z Guo
Objective: To discuss the curative effect and prognosis of cryoablation to high-risk and locally recurrent prostate cancer patients. Methods: Cryoablation related publications and relevant references were searched for potential pertinent articles until March, 2016.Articles were selected according to the exclusion criteria, Stata ver.11 was used to perform the statistical analysis. Results: 5-year biochemical disease-free survival of salvage ablation for prostate cancer was 45%(95% CI 0.43-0.47), in salvage radiotherapy of 45% (95% CI 0...
July 4, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28688613/brachytherapy-boost-utilization-and-survival-in-unfavorable-risk-prostate-cancer
#12
Skyler B Johnson, Nataniel H Lester-Coll, Jacqueline R Kelly, Benjamin H Kann, James B Yu, Sameer K Nath
BACKGROUND: There are limited comparative survival data for prostate cancer (PCa) patients managed with a low-dose rate brachytherapy (LDR-B) boost and dose-escalated external-beam radiotherapy (DE-EBRT) alone. OBJECTIVE: To compare overall survival (OS) for men with unfavorable PCa between LDR-B and DE-EBRT groups. DESIGN, SETTING, AND PARTICIPANTS: Using the National Cancer Data Base, we identified men with unfavorable PCa treated between 2004 and 2012 with androgen suppression (AS) and either EBRT followed by LDR-B or DE-EBRT (75...
July 5, 2017: European Urology
https://www.readbyqxmd.com/read/28687430/management-of-the-lateral-neck-in-well-differentiated-thyroid-cancer
#13
REVIEW
J R Cracchiolo, R J Wong
Lateral neck lymph node metastases in well differentiated thyroid cancer are common, ranging from 30% to 60%, with the majority of these foci identifiable only as microscopic deposits. A skilled ultrasound evaluation of the lymph nodes in the lateral neck is recommended for all patients presenting with newly diagnosed thyroid cancer undergoing surgical management. Ultrasound guided fine needle aspiration biopsy may be used to cytologically confirm suspected lateral neck nodal metastases prior to surgery. For patients with large volume nodal disease, extranodal extension, or multiple nodal metastases, computed tomography (CT) scan of the neck with contrast is an important additional imaging modality to accurately localize disease prior to surgery...
June 22, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28687398/the-impact-of-comorbidities-on-the-benefits-of-prolonged-androgen-ablation-in-patients-with-t3-4-prostate-cancer-treated-with-external-beam-radiation-therapy
#14
Eric Tran, Matthew Paquette, Justin Jay, Jeremy Hamm, Mitchell Liu, Graeme Duncan, Tom Pickles, Scott Tyldesley
PURPOSE: To determine whether the survival benefit associated with prolonged androgen deprivation therapy (ADT) and radiotherapy (EBRT) varies with baseline estimates of overall survival in cT3-4 prostate cancer patients (PCa). METHODS AND MATERIALS: In 1997, the BC Cancer Agency adopted as standard a policy of prolonged ADT (>18months) with EBRT for locally advanced PCa. Two cohorts of cT3-T4 PCa treated with EBRT were selected: 1993-1995 (early: N=725) and 1999-2001 (late: N=584)...
July 4, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28678408/longitudinal-regret-after-treatment-for-low-and-intermediate-risk-prostate-cancer
#15
Lauren M Hurwitz, Jennifer Cullen, Daniel J Kim, Sally Elsamanoudi, Jane Hudak, Maryellen Colston, Judith Travis, Huai-Ching Kuo, Kevin R Rice, Christopher R Porter, Inger L Rosner
BACKGROUND: Prostate cancer patients diagnosed with low- and intermediate-risk disease have several treatment options. Decisional regret after treatment is a concern, especially when poor oncologic outcomes or declines in health-related quality of life (HRQoL) occur. This study assessed determinants of longitudinal decisional regret in prostate cancer patients attending a multidisciplinary clinic and treated with radical prostatectomy (RP), external beam radiation therapy (EBRT), brachytherapy (BT), or active surveillance (AS)...
July 5, 2017: Cancer
https://www.readbyqxmd.com/read/28666541/management-of-elderly-women-with-endometrial-cancer
#16
Holm Eggemann, Tanja Ignatov, Elke Burger, Serban Dan Costa, Atanas Ignatov
BACKGROUND: Elderly women with endometrial cancer receive less therapy in comparison with their younger counterparts. The exact reason(s) for this treatment strategy remains unclear. PATIENTS AND METHODS: We performed a multicenter, retrospective registry-based study of 1550 patients with endometrial cancer. The outcome measure was the reason for not performing the indicated treatment. RESULTS: Median follow-up was 76.8months. A total of 1550 women were eligible for analysis: 353 (22...
June 27, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28664931/the-evolution-of-brachytherapy-for-prostate-cancer
#17
REVIEW
Nicholas G Zaorsky, Brian J Davis, Paul L Nguyen, Timothy N Showalter, Peter J Hoskin, Yasuo Yoshioka, Gerard C Morton, Eric M Horwitz
Brachytherapy (BT), using low-dose-rate (LDR) permanent seed implantation or high-dose-rate (HDR) temporary source implantation, is an acceptable treatment option for select patients with prostate cancer of any risk group. The benefits of HDR-BT over LDR-BT include the ability to use the same source for other cancers, lower operator dependence, and - typically - fewer acute irritative symptoms. By contrast, the benefits of LDR-BT include more favourable scheduling logistics, lower initial capital equipment costs, no need for a shielded room, completion in a single implant, and more robust data from clinical trials...
June 30, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28660291/adjuvant-hysterectomy-after-radiochemotherapy-for-locally-advanced-cervical-cancer
#18
Peter Hass, Holm Eggemann, Serban Dan Costa, Atanas Ignatov
BACKGROUND: External beam radiation therapy (EBRT) with concomitant chemotherapy (cCT) (=RCT) plus intracavitary (±interstitial) brachytherapy (iBT) is standard of care for advanced cervical cancer. The aim of this study was to evaluate morbidity and survival outcome of simple adjuvant hysterectomy (AH) after EBRT/cCT and to compare it with the standard treatment. PATIENTS AND METHODS: Patients with FIGO stage III cervical cancer were treated with EBRT/cCT and then divided in two groups: group 1 was further treated with standard intracavitary/interstitial BT, while group 2 underwent AH...
June 28, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28654573/patterns-of-adjuvant-therapy-utilization-in-uterine-carcinosarcoma-stages-i-to-iii-a-national-cancer-database-analysis
#19
William A Stokes, Tyler P Robin, Matthew W Jackson, Arya Amini, Tracey E Schefter, Carolyn C Lefkowits, Christine M Fisher
OBJECTIVE: The objective of this study is to characterize patterns of utilization of adjuvant chemotherapy (CT) and radiotherapy (RT) in the posthysterectomy management of uterine carcinosarcoma (UCS) in the United States. MATERIALS AND METHODS: We queried the National Cancer Database for women diagnosed with UCS between 2004 and 2012 and undergoing hysterectomy. Logistic regression was performed to identify sociodemographic, facility-specific, and treatment-related predictors of receiving multiagent chemotherapy, external beam radiotherapy (EBRT), or brachytherapy (BT)...
June 26, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28652121/high-intensity-focused-ultrasound-for-radio-recurrent-prostate-cancer-a-north-american-clinical-trial
#20
Tonye A Jones, Joseph Chin, David Mcleod, Jack Barkin, Allan Pantuck, Leonard S Marks
PURPOSE: To determine the safety and efficacy of whole-gland HIFU in men with radio-recurrent prostate cancer (CaP). MATERIALS AND METHODS: 100 men with clinically localized recurrence of CaP at least 2 years after EBRT received whole-gland HIFU in an open-label trial (2009 to 2012). Treatments were performed at 16 sites in the U.S. (14) and Canada (2). Primary endpoint was a combination of both PSA nadir ≤0.5 ng/ml and negative biopsy at 12 months. Validated questionnaires were used to monitor changes in urinary and sexual function...
June 23, 2017: Journal of Urology
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