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https://www.readbyqxmd.com/read/28546065/external-beam-radiotherapy-affects-serum-testosterone-in-patients-with-localized-prostate-cancer
#1
Raisa S Pompe, Pierre I Karakiewicz, Emanuele Zaffuto, Ariane Smith, Marco Bandini, Michele Marchioni, Zhe Tian, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Guila Delouya, Carole Lambert, Jean-Paul Bahary, Marie Claude Beauchemin, Maroie Barkati, Cynthia Ménard, Markus Graefen, Fred Saad, Derya Tilki, Daniel Taussky
BACKGROUND: Previous studies have examined testosterone levels after external beam radiation (EBRT) monotherapy, but since 2002 only sparse contemporary data have been reported. AIM: To examine testosterone kinetics in a large series of contemporary patients after EBRT. METHODS: The study was conducted in 425 patients who underwent definitive EBRT for localized prostate cancer from 2002 through 2014. Patients were enrolled in several phase II and III trials...
May 22, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28533800/high-dose-rate-interstitial-brachytherapy-in-head-and-neck-cancer-do-we-need-a-look-back-into-a-forgotten-art-a-single-institute-experience
#2
Rajendra Bhalavat, Manish Chandra, Vibhay Pareek, Lalitha Nellore, Karishma George, P Nandakumar, Pratibha Bauskar
PURPOSE: To evaluate the treatment outcomes with high-dose-rate (HDR) interstitial brachytherapy (HDR-BRT) in head and neck cancers (HNC). MATERIAL AND METHODS: Fifty-eight patients with HNC as per American Joint Committee on Cancer (AJCC) TNM staging criteria were analyzed retrospectively between 2008 and 2015. Forty-two patients received external beam radiotherapy (EBRT) with HDR-BRT and 16 patients received BRT alone. The survival was calculated with respect to median biological equivalent doses (BED) and median 2 Gy equivalent dose (EQD2), keeping α/β = 10 for tumor...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533799/definitive-three-dimensional-high-dose-rate-brachytherapy-for-inoperable-endometrial-cancer
#3
Lorena Draghini, Ernesto Maranzano, Michelina Casale, Fabio Trippa, Paola Anselmo, Fabio Arcidiacono, Stefania Fabiani, Marco Italiani, Luigia Chirico, Marco Muti
PURPOSE: To report our experience on high-dose-rate brachytherapy (HDR-BT) in patients with stage I-III endometrial cancer unfit to surgery. MATERIAL AND METHODS: Seventeen patients underwent HDR-BT as definitive treatment. Median age was 79 years (range, 60-95), median Karnofsky performance status 90% (range, 60-100). Histology was endometrial adenocarcinoma in 14 (82%), and non-endometrial in 3 (18%) patients. In 15 (88%) patients, clinical stage was I and in remaining 2 (12%) was III...
April 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28533162/which-patients-with-inoperable-vulvar-cancer-may-benefit-from-brachytherapy-in-addition-to-external-beam-radiation-a-surveillance-epidemiology-and-end-results-analysis
#4
Yuan James Rao, Caressa Hui, Anupama Chundury, Julie K Schwarz, Todd DeWees, Matthew A Powell, David G Mutch, Perry W Grigsby
PURPOSE: It is unknown whether brachytherapy after external beam radiation (EBRT + BT) results in improved outcomes compared with EBRT alone for patients with inoperable vulvar cancer. The purpose of this study was to compare survival outcomes for patients who received these treatment modalities. METHODS AND MATERIALS: Data between 1973 and 2011 from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were analyzed. Patients with Federation of International Gynecologists and Obstetricians stage I-IVA vulvar cancer treated with definitive EBRT + BT or EBRT alone were included...
May 19, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28532608/assessment-of-the-novel-online-delineation-workshop-dummy-run-approach-using-falcon-within-a-european-multicentre-trial-in-cervical-cancer-raids
#5
Eleonor Rivin Del Campo, Sofia Rivera, María Martínez-Paredes, Philippe Hupé, Andrea Slocker Escarpa, Isabelle Borget, Renaud Mazeron, Suzy Scholl, Amalia Palacios Eito, Christine Haie-Meder, Cyrus Chargari, Eric Deutsch
BACKGROUND AND PURPOSE: Online delineation workshops (ODW) permit training of geographically dispersed participants. The purpose is to evaluate the methodology of an ODW using FALCON to harmonize delineation within a European multicentre trial on locally advanced cervical cancer (LACC). MATERIAL AND METHODS: Two ODW included 46 clinicians (14 centres). Clinicians completed baseline (C1), guideline (C2) and final contours (C3) for external beam radiotherapy (EBRT) and brachytherapy (BT) for LACC...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28527010/glioblastoma-multiforme-gbm-in-the-elderly-initial-treatment-strategy-and-overall-survival
#6
Scott M Glaser, Michael J Dohopolski, Goundappa K Balasubramani, John C Flickinger, Sushil Beriwal
The EORTC trial which solidified the role of external beam radiotherapy (EBRT) plus temozolomide (TMZ) in the management of GBM excluded patients over age 70. Randomized studies of elderly patients showed that hypofractionated EBRT (HFRT) alone or TMZ alone was at least equivalent to conventionally fractionated EBRT (CFRT) alone. We sought to investigate the practice patterns and survival in elderly patients with GBM. We identified patients age 65-90 in the National Cancer Data Base (NCDB) with histologically confirmed GBM from 1998 to 2012 and known chemotherapy and radiotherapy status...
May 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28515807/external-validation-of-the-procars-nomograms-and-comparison-of-existing-risk-stratification-tools-for-localized-prostate-cancer
#7
David Tiberi, George Rodrigues, Tom Pickles, Jim Morris, Juanita Crook, Andre-Guy Martin, Fabio Cury, Charles Catton, Himu Lukka, Andrew Warner, Daniel Taussky
INTRODUCTION: The purpose of this study was to perform a direct comparison of several existing risk-stratification tools for localized prostate cancer in terms of their ability to predict for biochemical failure-free survival (BFFS). Two large databases were used and an external validation of two recently developed nomograms on an independent cohort was also performed in this analysis. METHODS: Patients who were treated with external beam radiotherapy (EBRT) and/or brachytherapy for localized prostate cancer were selected from the multi-institutional Genitourinary Radiation Oncologists of Canada (GUROC) Prostate Cancer Risk Stratification (ProCaRS) database (n=7974) and the Centre Hospitalier de l'Université de Montréal (CHUM) validation database (n=2266)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28511891/external-pelvic-and-vaginal-irradiation-vs-vaginal-irradiation-alone-as-postoperative-therapy-in-women-with-early-stage-uterine-serous-carcinoma-results-of-a-national-cancer-database-analysis
#8
Ankit Modh, Charlotte Burmeister, Adnan R Munkarah, Mohamed A Elshaikh
PURPOSE: Adjuvant treatment in early stage uterine serous carcinoma (USC) usually consists of chemotherapy with vaginal brachytherapy (VB), pelvic external beam radiation therapy (EBRT), or combination. We compared survival outcomes across these various radiation treatment modalities using the National Cancer Database. METHODS AND MATERIALS: The National Cancer Database was queried for adult females with histologically confirmed International Federation of Gynecology and Obstetrics 1988 Stage I-II USC diagnosed from 2003 to 2013 treated definitively with hysterectomy, adjuvant chemotherapy, and radiation therapy...
May 13, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28499487/external-beam-radiation-therapy-with-or-without-low-dose-rate-brachytherapy-analysis-of-favorable-and-unfavorable-intermediate-risk-prostate-cancer-patients
#9
Ahmed E Abugharib, Robert T Dess, Payal D Soni, Vrinda Narayana, Cheryl Evans, Mohamed S Gaber, Felix Y Feng, Patrick W McLaughlin, Daniel E Spratt
PURPOSE: To compare the tumor control and toxicity in men with intermediate-risk prostate cancer treated with either external beam radiation therapy (EBRT) or EBRT plus low-dose-rate brachytherapy (combo-RT). METHODS AND MATERIALS: Between 1995 and 2012, 579 men with intermediate-risk prostate cancer were treated with either EBRT (n = 388) or combo-RT (n = 191). Outcomes assessed included biochemical recurrence-free survival (bRFS), distant metastasis-free survival (DMFS), and cumulative incidence of genitourinary (GU) and gastrointestinal toxicity...
May 9, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28491264/priming-radioimmunotherapy-with-external-beam-radiation-in-patients-with-relapsed-low-grade-non-hodgkin-lymphoma
#10
Yazan Abuodeh, Kamran Ahmed, Michelle Echevarria, Arash Naghavi, G Daniel Grass, Timothy J Robinson, Michael Tomblyn, Bijal Shah, Julio Chavez, Celeste Bello, Ghassan El-Haddad, Louis Harrison, Sungjune Kim
BACKGROUND: The aim of this study was to evaluate the outcomes of priming salvage radioimmunotherapy (RIT) with a low dose of external beam radiotherapy (EBRT) in patients with relapsed low grade non-Hodgkin lymphoma (LG-NHL). METHODS: Patients who received salvage RIT with or without 2 × 2 Gy EBRT between March 2009 and February 2013 were retrospectively reviewed at a single institution. Planning target volume (PTV) for EBRT was created by adding a 1-2 cm expansion to the gross tumor volume depending on the anatomical location...
April 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/28470944/patterns-of-practice-survey-for-brachytherapy-for-cervix-cancer-in-australia-and-new-zealand
#11
Karen Lim, Sylvia van Dyk, Pearly Khaw, Jacqueline Veera, Linda Mileshkin, Lucy Ohanessian, Michelle Harrison, Shalini K Vinod
INTRODUCTION: The purpose of this survey was to explore the current patterns of practice for brachytherapy in cervix cancer in Australia and New Zealand. The survey was also intended to explore clinician attitudes towards image-guided adaptive brachytherapy (IGABT) and identify barriers to the implementation of IGABT. METHODS: Electronic surveys were sent to all radiotherapy centres in Australia and New Zealand under collaboration with Australia New Zealand Gynaecology and Oncology Group (ANZGOG), in order to identify patterns of radiotherapy practice...
May 4, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28464906/adjuvant-radiotherapy-after-radical-cystectomy-for-patients-with-muscle-invasive-bladder-cancer-a-phase-ii-trial
#12
Valérie Fonteyne, Piet Dirix, Sara Junius, Elke Rammant, Piet Ost, Gert De Meerleer, Martijn Swimberghe, Karel Decaestecker
BACKGROUND: Neo-adjuvant chemotherapy followed by radical cystectomy with extended pelvic lymph node dissection is considered to be the treatment of choice for patients with muscle invasive bladder cancer (MIBC). Despite this aggressive treatment the outcome is poor and ultimately, 30% of the patients with ≥pT3 tumors develop a pelvic recurrence. We hypothesize that postoperative adjuvant external beam radiotherapy (EBRT) might prevent local and lymph node recurrence and improve disease free- and overall survival as loco-regional recurrence is linked to the development of distant metastasis...
May 2, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28464446/unification-of-favorable-intermediate-unfavorable-intermediate-and-very-high-risk-stratification-criteria-for-prostate-cancer
#13
Zachary S Zumsteg, Michael J Zelefsky, Kaitlin M Woo, Daniel E Spratt, Marisa A Kollmeier, Sean McBride, Xin Pei, Howard M Sandler, Zhigang Zhang
OBJECTIVE: To improve on the existing risk-stratification systems. PATIENTS AND METHODS: This was a retrospective investigation including 2248 patients undergoing dose-escalated external beam radiotherapy (EBRT) at a single institution. We separated National Comprehensive Cancer Network (NCCN) intermediate-risk prostate cancer into favorable and unfavorable groups based on primary Gleason pattern, percentage of positive biopsy cores (PPBC), and number of NCCN intermediate-risk factors...
May 2, 2017: BJU International
https://www.readbyqxmd.com/read/28463150/external-beam-radiation-therapy-or-brachytherapy-with-or-without-short-course-neoadjuvant-androgen-deprivation-therapy-results-of-a-multicenter-prospective-study-of-quality-of-life
#14
Hiram A Gay, Martin G Sanda, Jingxia Liu, Ningying Wu, Daniel A Hamstra, John T Wei, Rodney L Dunn, Eric A Klein, Howard M Sandler, Christopher S Saigal, Mark S Litwin, Deborah A Kuban, Larry Hembroff, Meredith M Regan, Peter Chang, Jeff M Michalski
PURPOSE: The long-term effects of neoadjuvant androgen deprivation therapy (NADT) with radiation therapy on participant-reported health-related quality of life (HRQOL) have not been characterized in prospective multicenter studies. We evaluated HRQOL for 2 years among participants undergoing radiation therapy (RT) with or without NADT for newly diagnosed, early-stage prostate cancer. METHODS AND MATERIALS: We analyzed longitudinal cohort data from the Prostate Cancer Outcomes and Satisfaction with Treatment Quality Assessment Consortium to ascertain the HRQOL trajectory of men receiving NADT with external beam RT (EBRT) or brachytherapy...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28451427/external-beam-radiation-for-the-treatment-of-castration-resistant-prostate-cancer-following-primary-hormonal-therapy-with-androgen-ablation-analysis-and-outcome-of-21-patients
#15
Teele Kuusk, Kristiina Pulliainen, Markku H Vaarala
Patients who undergo early androgen-deprivation therapy for prostate cancer may eventually develop castration-resistant prostate cancer. However, no optimal treatment for non-metastasized castration-resistant prostate cancer has yet been established. In the present retrospective, single-institutional study, the radiotherapy (RT) outcomes were evaluated in patients who underwent androgen-deprivation therapy for non-metastatic prostate cancer and subsequently developed castration-resistant disease. Following a thorough chart review, the data of 21 patients with castration-resistant prostate cancer who were treated between 2000 and 2010 with external beam radiation therapy (EBRT) at a prostate radiation dose of >45 Gy were evaluated...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28449703/a-short-time-interval-between-radiotherapy-and-hyperthermia-reduces-in-field-recurrence-and-mortality-in-women-with-advanced-cervical-cancer
#16
Caspar M van Leeuwen, Arlene L Oei, Kenneth W T K Chin, Johannes Crezee, Arjan Bel, Anneke M Westermann, Marrije R Buist, Nicolaas A P Franken, Lukas J A Stalpers, H Petra Kok
BACKGROUND: Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggests that the radiosensitizing effect of hyperthermia decreases substantially for time intervals between radiotherapy and hyperthermia as short as 1-2 h, but clinical evidence is limited. The purpose of this study is to determine the effect of the time interval between external beam radiotherapy (EBRT) and same-day hyperthermia on in-field recurrence rate, overall survival and late toxicity in women with advanced stage cervical cancer...
April 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28446057/comparison-of-survival-outcomes-following-postsurgical-radioactive-iodine-versus-external-beam-radiation-in-stage-iv-differentiated-thyroid-carcinoma
#17
Zao Yang, Jose Flores, Sanford Katz, Cherie-Ann Nathan, Vikas Mehta
BACKGROUND: There is a lack of well-powered data regarding outcomes in stage IV differentiated thyroid carcinoma (DTC) treated with postsurgical radiation. The objective of this study was to examine survival in patients with stage IV papillary thyroid carcinoma (PTC) and follicular thyroid carcinoma (FTC) who received radioactive iodine (RAI), external beam radiation therapy (EBRT), or neither following surgery. METHODS: In this retrospective cohort study, data collected from the National Cancer Data Base (NCDB) yielded 11,832 patients with stage IV DTC who underwent primary surgical treatment between 2002 and 2012...
May 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28445167/spatial-features-of-dose-surface-maps-from-deformably-registered-plans-correlate-with-late-gastrointestinal-complications
#18
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
This study investigates the associations between spatial distribution of dose to the rectal surface and observed gastrointestinal toxicities after deformably registering each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate brachytherapy (HDRBT) prostate cancer treatment. The study contains data for 118 patients where the HDRBT CT was deformably-registered to the EBRT CT. The EBRT and registered HDRBT TG43 dose distributions in a reference 2 Gy/fraction were 3D-summed. Rectum dose-surface maps (DSMs) were obtained by virtually unfolding the rectum surface slice-by-slice...
May 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28443145/initial-single-centre-canadian-experience-with-18f-fluoromethylcholine-positron-emission-tomography-computed-tomography-18f-fch-pet-ct-for-biochemical-recurrence-in-prostate-cancer-patients-initially-treated-with-curative-intent
#19
Simon Gauvin, Yannick Cerantola, Eléonore Haberer, Vincent Pelsser, Stephan Probst, Franck Bladou, Maurice Anidjar
INTRODUCTION: We sought to determine predictive factors (patient and prostate-specific antigen [PSA] characteristics) for 18F-fluoromethylcholine positron emission tomography-computed tomography (18F-FCH PET/CT) positivity in the context of biochemical recurrence after local treatment of prostate cancer (PCa) with curative intent. METHODS: This is a retrospective study including 60 18F-FCH PET/CT scans of patients with biochemical recurrence after initial radical prostatectomy (RP), external beam radiation therapy (EBRT), or focal high-intensity focused ultrasound (HIFU) with curative intent...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28442277/prostate-brachytherapy-either-alone-or-in-combination-with-external-beam-radiation-is-associated-with-longer-overall-survival-in-men-with-favorable-pathologic-group-4-gleason-score-8-prostate-cancer
#20
Matthew W Jackson, Arya Amini, Bernard L Jones, Brian Kavanagh, Paul Maroni, Steven J Frank, Usama Mahmood, Rajat J Kudchadker, Thomas J Pugh
PURPOSE: Conventional prostate cancer risk stratification results in considerable heterogeneity within each prognostic group. Men with pathologic grade Group 4 (Gleason score 8) but otherwise low-risk features have been identified as a favorable subset of high-risk prostate cancer. Given recent randomized data supporting improved cancer outcome with brachytherapy in intermediate- and high-risk prostate cancer, we sought to evaluate brachytherapy utilization and overall survival (OS) for these patients...
April 23, 2017: Brachytherapy
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