keyword
MENU ▼
Read by QxMD icon Read
search

Microgravity

keyword
https://www.readbyqxmd.com/read/29785723/decreased-e-cadherin-in-mcf7-human-breast-cancer-cells-forming-multicellular-spheroids-exposed-to-simulated-microgravity
#1
Jayashree Sahana, Mohamed Zakaria Nassef, Markus Wehland, Sascha Kopp, Marcus Krüger, Thomas J Corydon, Manfred Infanger, Johann Bauer, Daniela Grimm
MCF7 human breast cancer cells were cultured under normal gravity (1g) and on a random positioning machine (RPM) preventing sedimentation. After two weeks, adherent 1g-control and adherent RPM cells (AD) as well as multicellular spheroids (MCS) were harvested. AD and MCS had been exposed to the RPM in the same culture flask. In a subsequent proteome analysis, the majority of the proteins detected showed similar label-free quantification scores (LFQ) in each of the respective subpopulations, but in both AD or MCS cultures, proteins were also found whose LFQs deviated at least twofold from their counterparts in the 1g-control cells...
May 21, 2018: Proteomics
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#2
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29773841/ocular-counter-rolling-in-astronauts-after-short-and-long-duration-spaceflight
#3
Millard F Reschke, Scott J Wood, Gilles Clément
Ocular counter-rolling (OCR) is a reflex generated by the activation of the gravity sensors in the inner ear that stabilizes gaze and posture during head tilt. We compared the OCR measures that were obtained in 6 astronauts before, during, and after a spaceflight lasting 4-6 days with the OCR measures obtained from 6 astronauts before and after a spaceflight lasting 4-9 months. OCR in the short-duration fliers was measured using the afterimage method during head tilt at 15°, 30°, and 45°. OCR in the long-duration fliers was measured using video-oculography during whole body tilt at 25°...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768035/microgravity-induced-ocular-changes-are-related-to-body-weight
#4
Jay C Buckey, Scott D Phillips, Allison P Anderson, Ariane B Chepko, Veronique Archambault-Leger, Jiang Gui, Abigail M Fellows
On Earth, tissue weight generates compressive forces that press on body structures and act on the walls of vessels throughout the body. In microgravity tissues no longer have any weight and tissue compressive forces are lost, suggesting individuals who weigh more may show greater effects from microgravity exposure. One unique effect of long-duration microgravity exposure is the spaceflight-associated neuro-ocular syndrome (SANS) which can present with globe flattening, choroidal folds, optic disc edema, and a hyperopic visual shift...
May 16, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29765449/effects-of-single-and-combined-low-frequency-electromagnetic-fields-and-simulated-microgravity-on-gene-expression-of-human-mesenchymal-stem-cells-during-chondrogenesis
#5
Susanne Mayer-Wagner, Florian Hammerschmid, Helmut Blum, Stefan Krebs, Julia I Redeker, Boris M Holzapfel, Volkmar Jansson, Peter E Müller
Introduction: Low frequency electromagnetic fields (LF-EMF) and simulated microgravity (SMG) have been observed to affect chondrogenesis. A controlled bioreactor system was developed to apply LF-EMF and SMG singly or combined during chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in 3D culture. Material and methods: An external motor gear SMG bioreactor was combined with magnetic Helmholtz coils for EMF (5 mT; 15 Hz). Pellets of hMSCs (±TGF-β3) were cultured (P5) under SMG, LF-EMF, LF-EMF/SMG and control (1 g) conditions for 3 weeks...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29760957/simulated-microgravity-induces-a-cellular-regression-of-the-mature-phenotype-in-human-primary-osteoblasts
#6
Magda Gioia, Anna Michaletti, Manuel Scimeca, Mario Marini, Umberto Tarantino, Lello Zolla, Massimo Coletta
Decreased mechanical loading on bones, such as prolonged bed rest and microgravity during space flights, leads to the development of an osteoporotic-like phenotype. Although osteoblast hypo-functionality is reported to be involved in the progression of bone pathological conditions, the cellular mechanisms of this process remain largely unknown. The combined application of mass spectrometry "-omics" and histochemical and ultrastructural approaches have been employed to investigate the effects of the gravitational unloading on human bone-cell biology...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29753413/development-of-a-step-down-method-for-altering-male-c57bl-6-mouse-housing-density-and-hierarchical-structure-preparations-for-spaceflight-studies
#7
David C Scofield, Jeffrey D Rytlewski, Paul Childress, Kishan Shah, Aamir Tucker, Faisal Khan, Jessica Peveler, Ding Li, Todd O McKinley, Tien-Min G Chu, Debra L Hickman, Melissa A Kacena
This study was initiated as a component of a larger undertaking designed to study bone healing in microgravity aboard the International Space Station (ISS). Spaceflight experimentation introduces multiple challenges not seen in ground studies, especially with regard to physical space, limited resources, and inability to easily reproduce results. Together, these can lead to diminished statistical power and increased risk of failure. It is because of the limited space, and need for improved statistical power by increasing sample size over historical numbers, NASA studies involving mice require housing mice at densities higher than recommended in the Guide for the Care and Use of Laboratory Animals (National Research Council, 2011)...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29753412/biological-filters-and-their-use-in-potable-water-filtration-systems-in-spaceflight-conditions
#8
REVIEW
Starla G Thornhill, Manish Kumar
Providing drinking water to space missions such as the International Space Station (ISS) is a costly requirement for human habitation. To limit the costs of water transport, wastewater is collected and purified using a variety of physical and chemical means. To date, sand-based biofilters have been designed to function against gravity, and biofilms have been shown to form in microgravity conditions. Development of a universal silver-recycling biological filter system that is able to function in both microgravity and full gravity conditions would reduce the costs incurred in removing organic contaminants from wastewater by limiting the energy and chemical inputs required...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29753408/a-urine-fuelled-soil-based-bioregenerative-life-support-system-for-long-term-and-long-distance-manned-space-missions
#9
Federico Maggi, Fiona H M Tang, Céline Pallud, Chuanhui Gu
A soil-based cropping unit fuelled with human urine for long-term manned space missions was investigated with the aim to analyze whether a closed-loop nutrient cycle from human liquid wastes was achievable. Its ecohydrology and biogeochemistry were analysed in microgravity with the use of an advanced computational tool. Urine from the crew was used to supply primary (N, P, and K) and secondary (S, Ca and Mg) nutrients to wheat and soybean plants in the controlled cropping unit. Breakdown of urine compounds into primary and secondary nutrients as well as byproduct gases, adsorbed, and uptake fractions were tracked over a period of 20 years...
May 2018: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29745800/interaction-between-graviception-and-carotid-baroreflex-function-in-humans-during-parabolic-flight-induced-microgravity
#10
Shigehiko Ogoh, Michaël Marais, Romain Lericollais, Pierre Denise, Peter B Raven, Hervé Normand
The aim of the present study was to assess carotid baroreflex (CBR) during acute changes in otolithic activity in humans. To address this question, we designed a set of experiments to identify the modulatory effects of microgravity on CBR function at a tilt angle of -2{degree sign}, which was identified to minimize changes in central blood volume during parabolic flight. During parabolic flight at 0g and 1g, CBR function curves were modelled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulse trains of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr; CBR control of HR (carotid-HR) and MAP (carotid-MAP) baroreflex function curves, respectively...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29745771/effect-of-microgravity-space-radiation-on-microbes
#11
Giuliana Senatore, Felice Mastroleo, Natalie Leys, Gianluigi Mauriello
One of the new challenges facing humanity is to reach increasingly further distant space targets. It is therefore of upmost importance to understand the behavior of microorganisms that will unavoidably reach the space environment together with the human body and equipment. Indeed, microorganisms could activate their stress defense mechanisms, modifying properties related to human pathogenesis. The host-microbe interactions, in fact, could be substantially affected under spaceflight conditions and the study of microorganisms' growth and activity is necessary for predicting these behaviors and assessing precautionary measures during spaceflight...
May 10, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29745601/-effect-of-simulated-microgravity-on-peripheral-oxygen-saturation-in-rats
#12
Guangfei Chen, Yahui Zhang, Ming Yuan, Shilin He, Jun Ying, Chen Li
To study the effect of microgravity on peripheral oxygen saturation (SpO 2 ) in rats, tail-suspended rats were applied to simulate microgravity environment. SpO 2 and arterial oxygen saturation (SaO 2 ) were measured by pulse oximeter and arterial blood gas analyzer (ABGA) respectively on the 14th day, 21st day and 28th day in tail-suspended group and control group. Paired t -test shows that SpO 2 was significantly lower than SaO 2 in tail-suspended group on the 14th day ( P < 0.05), the 21st day ( P < 0...
February 1, 2018: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29722618/noninvasive-in-ear-monitoring-of-intracranial-pressure-during-microgravity-in-parabolic-flights
#13
Paul Avan, Herve Normand, Fabrice Giraudet, Gregory Gerenton, Pierre Denise
Among possible causes of visual impairment or headache experienced by astronauts in microgravity or post-flight and that hamper their performance, elevated intracranial pressure (ICP) has been invoked, but never measured for lack of non-invasive methods. The goal of this work was to test two noninvasive methods of ICP monitoring using in-ear detectors of ICP-dependent auditory responses, acoustic and electric, in acute microgravity afforded by parabolic flights. The devices detecting these responses were hand-held tablets routinely used in otolaryngology for hearing diagnosis, customized for ICP extraction and serviceable by unskilled operators...
May 3, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29704889/from-spaceflight-to-blood-doping-devices-for-assessing-haemoglobin-mass-and-intravascular-volumes
#14
EDITORIAL
Andreas Breenfeldt Andersen, Laura Oberholzer, Thomas Haider, Anne-Kristine Meinild-Lundby, Nazzareno Fagoni
As highlighted recently in this journal,1 but also in others, quantification of total haemoglobin mass (Hbmass ), red blood cell volume (RBCV), plasma volume (PV), and blood volume (BV) is common and relevant in a clinical and scientific context.1-5 For instance, a decline in BV is observed in artificial microgravity and during spaceflight, while a PV reduction is observed when sojourning to high altitude.2 Moreover, Hbmass and RBCV are two major determinants of physical performance,1 and measuring Hbmass might be a potential technique to detect blood doping...
April 28, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29687904/unitary-physiology
#15
John S Torday, William B Miller
The common relationships among a great variety of biological phenomena seem enigmatic when considered solely at the level of the phenotype. The deep connections in physiology, for example, between the effects of maternal food restriction in utero and the subsequent incidence of metabolic syndrome in offspring, the effects of microgravity on cell polarity and reproduction in yeast, stress effects on jellyfish, and their endless longevity, or the relationship between nutrient abundance and the colonial form in slime molds, are not apparent by phenotypic observation...
March 25, 2018: Comprehensive Physiology
https://www.readbyqxmd.com/read/29687393/mechanical-stimulation-of-adipose-derived-stem-cells-for-functional-tissue-engineering-of-the-musculoskeletal-system-via-cyclic-hydrostatic-pressure-simulated-microgravity-and-cyclic-tensile-strain
#16
Rachel C Nordberg, Josie C Bodle, Elizabeth G Loboa
It is critical that human adipose stem cell (hASC) tissue-engineering therapies possess appropriate mechanical properties in order to restore function of the load bearing tissues of the musculoskeletal system. In an effort to elucidate the hASC response to mechanical stimulation and develop mechanically robust tissue engineered constructs, recent research has utilized a variety of mechanical loading paradigms including cyclic tensile strain, cyclic hydrostatic pressure, and mechanical unloading in simulated microgravity...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29686401/simulated-microgravity-mars-gravity-and-2g-hypergravity-affect-cell-cycle-regulation-ribosome-biogenesis-and-epigenetics-in-arabidopsis-cell-cultures
#17
Khaled Y Kamal, Raúl Herranz, Jack J W A van Loon, F Javier Medina
Gravity is the only component of Earth environment that remained constant throughout the entire process of biological evolution. However, it is still unclear how gravity affects plant growth and development. In this study, an in vitro cell culture of Arabidopsis thaliana was exposed to different altered gravity conditions, namely simulated reduced gravity (simulated microgravity, simulated Mars gravity) and hypergravity (2g), to study changes in cell proliferation, cell growth, and epigenetics. The effects after 3, 14, and 24-hours of exposure were evaluated...
April 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29684676/fabrication-of-nanofibrous-microcarriers-mimicking-extracellular-matrix-for-functional-microtissue-formation-and-cartilage-regeneration
#18
Yansen Wang, Xueling Yuan, Kun Yu, Haoye Meng, Yudong Zheng, Jiang Peng, Shibi Lu, Xiaotong Liu, Yajie Xie, Kun Qiao
Cartilage has rather limited capacities for self-repair and regeneration. To repair complexly shaped cartilage tissue defects, we propose the application of microtissues fabricated from bone marrow-derived mesenchymal stem cells (BMSCs) cultured in natural bionic nanofibrous microcarriers (NF-MCs). The NF-MCs were structurally and functionally designed to mimic natural extracellular matrix (ECM) by crosslinking dialdehyde bacterial cellulose (DBC) with DL-allo-hydroxylysine (DHYL) and complexing chitosan (CS) with DHYL through electrostatic interactions...
April 16, 2018: Biomaterials
https://www.readbyqxmd.com/read/29674976/neocytolysis-how-to-get-rid-of-the-extra-erythrocytes-formed-by-stress-erythropoiesis-upon-descent-from-high-altitude
#19
REVIEW
Heimo Mairbäurl
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood. Neocytolysis likely aims at decreasing this excess amount of erythrocytes and hemoglobin (Hb) when it is not required anymore and to decrease blood viscosity. Neocytolysis seems to occur upon descent from high altitude. Similar processes seem to occur in microgravity, and are also discussed to mediate the replacement of erythrocytes containing fetal hemoglobin (HbF) with those having adult hemoglobin (HbA) after birth...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29662460/sensation-seeking-and-adaptation-in-parabonauts
#20
Aurélie Collado, Jean-Philippe Hainaut, Vincent Monfort, Benoît Bolmont
Evidence from extreme environments suggests that there are relationships between difficulties of adaptation and psychological factors such as personality. In the framework of microgravity research on humans, the aim of this exploratory study was to investigate inter-individual differences of parabonauts on the basis of quality of adaptation to the physical demands of parabolic flights. The personality characteristics of two groups of parabonauts with a different quality of adaptation (an Adaptive group, N = 7, and a Maladaptive group, N = 15) were assessed using the Sensation Seeking Scale, Brief COPE, and MSSQ-Short...
2018: Frontiers in Psychology
keyword
keyword
11229
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"