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Chronic inflamation and HSC

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https://www.readbyqxmd.com/read/27470513/e-selectin-inhibition-mitigates-splenic-hsc-activation-and-myelopoiesis-in-hypercholesterolemic-mice-with-myocardial-infarction
#1
Partha Dutta, Friedrich Felix Hoyer, Yuan Sun, Yoshiko Iwamoto, Benoit Tricot, Ralph Weissleder, John L Magnani, Filip K Swirski, Matthias Nahrendorf
OBJECTIVE: Atherosclerosis is a chronic disease characterized by lipid accumulation in the arterial wall. After myocardial infarction (MI), atherosclerotic plaques are infiltrated by inflammatory myeloid cells that aggravate the disease and increase the risk of secondary myocardial ischemia. Splenic myelopoiesis provides a steady flow of myeloid cells to inflamed atherosclerotic lesions after MI. Therefore, targeting myeloid cell production in the spleen could ameliorate increased atherosclerotic plaque inflammation after MI...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/10385656/transforming-growth-factor-beta-and-tumor-necrosis-factor-alpha-inhibit-both-apoptosis-and-proliferation-of-activated-rat-hepatic-stellate-cells
#2
B Saile, N Matthes, T Knittel, G Ramadori
Transforming growth factor beta (TGF-beta) as well as tumor necrosis factor alpha (TNF-alpha) gene expression are up-regulated in chronically inflamed liver. These cytokines were investigated for their influence on apoptosis and proliferation of activated hepatic stellate cells (HSCs). Spontaneous apoptosis in activated HSC was significantly down-regulated by 53% +/- 8% (P <.01) under the influence of TGF-beta and by 28% +/- 2% (P <.05) under the influence of TNF-alpha. TGF-beta and TNF-alpha significantly reduced expression of CD95L in activated HSCs, whereas CD95 expression remained unchanged...
July 1999: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/10347117/insulin-and-insulin-like-growth-factor-1-stimulate-proliferation-and-type-i-collagen-accumulation-by-human-hepatic-stellate-cells-differential-effects-on-signal-transduction-pathways
#3
G Svegliati-Baroni, F Ridolfi, A Di Sario, A Casini, L Marucci, G Gaggiotti, P Orlandoni, G Macarri, L Perego, A Benedetti, F Folli
Insulin and insulin-like growth factor (IGF-1) are mitogenic for fibroblasts and smooth muscle cells. IGF-1 increases in inflamed and fibrotic tissues and induces proliferation of rat hepatic stellate cells (HSC). This study evaluates the potential roles of these hormones in the development of liver fibrosis. Insulin and IGF-1 receptor expression was evaluated by immunohistochemistry in both cultured human HSC and human liver tissue. Phosphorylation of both 70-kd S6 kinase and extracellular-regulated kinase (ERK), cell proliferation, type I collagen gene expression, and accumulation in HSC culture media were evaluated by Western blot, immunohistochemistry for bromodeoxyuridine (BrdU), Northern blot, and enzyme-linked immunosorbent assay, respectively...
June 1999: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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