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Yao Yu, Marc Mabray, William Silveira, Peter Y Shen, William R Ryan, Alina Uzelac, Sue S Yom
BACKGROUND: The purpose of this study was to test if diffusion-weighted imaging (DWI) identified persistent neck disease after chemoradiotherapy (CRT) for oropharyngeal cancer earlier and as accurately as subsequent positron emission tomography (PET)/CT. METHODS: We performed a review of patients with oropharyngeal cancer treated with definitive CRT who underwent DWI and PET/CT at a median of 8 and 14 weeks posttreatment. Imaging characteristics were correlated with pathologically proven neck failure...
October 11, 2016: Head & Neck
Mekhail Anwar, Yao Yu, Christine M Glastonbury, Ivan H El-Sayed, Sue S Yom
PURPOSE: The ophthalmic nerve (cranial nerve V-1) runs in close proximity to the globe, optic nerve, chiasm, and brain. The purpose of this study was to provide contouring guidance using computed tomography (CT)-identifiable landmarks, based on an analysis of skin cancer patients with V-1 invasion. METHODS AND MATERIALS: Radiation oncology planning CT scans were analyzed for landmarks to guide V-1 target delineation from the skin surface to the trigeminal ganglion...
March 16, 2016: Practical Radiation Oncology
Alan Kiang, Vivian K Weinberg, Ka Ho Nicholas Cheung, Erin Shugard, Josephine Chen, Jeanne M Quivey, Sue S Yom
BACKGROUND: There is a lack of data on quality of life in long-term survivors of nasopharyngeal carcinoma (NPC) who have been treated with intensity-modulated radiation therapy (IMRT). We characterized long-term disease-specific and cognitive QoL in NPC survivors after IMRT. METHODS: We conducted a cross-sectional study of surviving patients diagnosed and treated for NPC at our center with curative-intent IMRT, with or without chemotherapy. Patients who were deceased, still undergoing treatment, with known recurrent disease, or treated with RT modality other than IMRT were excluded...
2016: Radiation Oncology
Jonathan J Beitler, Harry Quon, Christopher U Jones, Joseph K Salama, Paul M Busse, Jay S Cooper, Shlomo A Koyfman, John A Ridge, Nabil F Saba, Farzan Siddiqui, Richard V Smith, Francis Worden, Min Yao, Sue S Yom
BACKGROUND: There are no level I studies to guide treatment for resectable oropharyngeal squamous cell carcinoma (SCC). Treatment toxicities influence management recommendations. Ongoing investigations are examining deintensified treatments for human papillomavirus (HPV)-associated oropharyngeal SCC. METHODS: The Appropriateness Criteria panel, using modified Delphi methodology, produced a literature summary, an assessment of treatment recommendations, and cases to illustrate their use...
September 2016: Head & Neck
Sue S Yom, Apar K Ganti, Andreas Dietz
Scientific investigation is extremely active in the treatment, management, and optimization of therapies for patients with head and neck cancer. These issues have undergone recent rapid evolution in response to a changing epidemiology based on an increasing proportion of HPV-associated oropharyngeal cancer with advances in multimodality technologies to improve outcomes and reduce toxicity. Choices of definitive treatment of various anatomic subsites are being refined, balancing the relative indications and advantages of surgery or chemoradiation-based strategies...
2016: American Society of Clinical Oncology Educational Book
Daniel S W Tan, Sue S Yom, Ming S Tsao, Harvey I Pass, Karen Kelly, Nir Peled, Rex C Yung, Ignacio I Wistuba, Yasushi Yatabe, Michael Unger, Philip C Mack, Murry W Wynes, Tetsuya Mitsudomi, Walter Weder, David Yankelevitz, Roy S Herbst, David R Gandara, David P Carbone, Paul A Bunn, Tony S K Mok, Fred R Hirsch
Mutations in the epidermal growth factor receptor gene (EGFR) represent one of the most frequent "actionable" alterations in non-small cell lung cancer (NSCLC). Typified by high response rates to targeted therapies, EGFR tyrosine kinase inhibitors (TKIs) are now established first-line treatment options and have transformed the treatment paradigm for NSCLC. With the recent breakthrough designation and approval of the third-generation EGFR TKI osimertinib, available systemic and local treatment options have expanded, requiring new clinical algorithms that take into account individual patient molecular and clinical profiles...
July 2016: Journal of Thoracic Oncology
Nabil F Saba, Joseph K Salama, Jonathan J Beitler, Paul M Busse, Jay S Cooper, Christopher U Jones, Shlomo Koyfman, Harry Quon, John A Ridge, Farzan Siddiqui, Francis Worden, Min Yao, Sue S Yom
BACKGROUND: Nasopharyngeal carcinoma (NPC) presents mostly with locally advanced disease and is treated with multimodal therapy; however, consensus is lacking for different clinical scenarios. METHODS: The American College of Radiology (ACR) Appropriateness Criteria® are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel...
July 2016: Head & Neck
Sue S Yom
No abstract text is available yet for this article.
September 2016: Practical Radiation Oncology
Erin Shugard, Josephine Chen, Jeanne M Quivey, Christine M Glastonbury, Elham Khanafshar, Adam A Garsa, Jonathan R George, Sue S Yom
INTRODUCTION: Due to complex multimodal treatments and a lengthy natural history of disease, the impact of radiation therapy for well-differentiated thyroid cancer (WDTC) is challenging to evaluate. We analysed the effect of dose escalation, as enabled by intensity-modulated radiation therapy (IMRT), on preventing local-regional failure (LRF) of microscopic and macroscopic WDTC. METHOD: We performed a retrospective review of WDTC patients treated with IMRT from 1998-2011...
August 2016: Journal of Medical Imaging and Radiation Oncology
Lisa Singer, Sarah M Calkins, Andrew E Horvai, William R Ryan, Sue S Yom
BACKGROUND: Head and neck cancer is often managed with a combination of surgery, radiation therapy, and chemotherapy, and skin toxicity is not uncommon. Xanthogranuloma is a pathological finding resulting from an inflammatory reaction that has not been previously reported following head and neck radiation therapy. CASE PRESENTATION: A patient with squamous cell carcinoma of the oropharynx, treated with definitive chemoradiation and hyperthermia, presented at eight-month follow-up with an in-field cutaneous lesion in the low neck, initially concerning for recurrent tumor...
2016: Journal of Otolaryngology—Head & Neck Surgery
Christopher H Chapman, Nabil F Saba, Sue S Yom
The epidermal growth factor receptor (EGFR) is preferentially expressed in head and neck squamous cell carcinoma (HNSCC), and is a promising therapeutic target. Yet other than cetuximab, no agent targeting EGFR has been approved for this disease, and none has shown benefit over the standard of care. Several randomized trials of antibody and small molecule agents have found no new indication for these agents, despite their initial promise. In this review, we examine the major clinical evidence and discuss potential future developments of translational science in this area, including use of these agents in risk-stratified subgroups, inhibition of downstream/parallel targets, and combination with immunotherapy...
February 2016: Annals of Translational Medicine
Yao Yu, Josephine Chen, Celeste I Leary, Erin Shugard, Sue S Yom
Radiation of the low neck can be accomplished using split-field intensity-modulated radiation therapy (sf-IMRT) or extended-field intensity-modulated radiation therapy (ef-IMRT). We evaluated the effect of these treatment choices on target coverage and thyroid and larynx doses. Using data from 14 patients with cancers of the oropharynx, we compared the following 3 strategies for radiating the low neck: (1) extended-field IMRT, (2) traditional split-field IMRT with an initial cord-junction block to 40Gy, followed by a full-cord block to 50Gy, and (3) split-field IMRT with a full-cord block to 50Gy...
2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
Gwen Wyatt, Stephanie L Pugh, Raimond K W Wong, Stephen Sagar, Anurag K Singh, Shlomo A Koyfman, Phuc F Nguyen-Tân, Sue S Yom, Francis S Cardinale, Khalil Sultanem, Ian Hodson, Greg A Krempl, Barbara Lukaszczyk, Alexander M Yeh, Lawrence Berk
PURPOSE: The purpose of this secondary analysis was to determine change in overall health-related quality of life (HRQOL) based on patient data obtained from NRG Oncology RTOG 0537 as measured by the RTOG-modified University of Washington Head and Neck Symptom Score (RM-UWHNSS). METHODS: A multi-site prospective randomized clinical trial design stratified 137 patients with post-radiation therapy xerostomia according to prior pilocarpine (PC) treatment and time after radiation therapy and/or chemotherapy and randomized patients into two groups...
September 2016: Quality of Life Research
June Corry, Sue S Yom
No abstract text is available yet for this article.
February 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Shlomo A Koyfman, Jay S Cooper, Jonathan J Beitler, Paul M Busse, Christopher U Jones, Mark W McDonald, Harry Quon, John A Ridge, Nabil F Saba, Joseph K Salama, Farzan Siddiqui, Richard V Smith, Francis Worden, Min Yao, Sue S Yom
BACKGROUND: Aggressive nonmelanomatous skin cancer (NMSC) of the head and neck presents an increasingly common therapeutic challenge for which prospective clinical trials are lacking. METHODS: The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel...
February 2016: Head & Neck
Sue S Yom
HPV is the most common sexually transmitted disease, but the overwhelming majority of individuals clear the infection. A small percentage of individuals develop persistence of oncogenic HPV types, especially HPV-16; and as a result, squamous cell carcinoma can develop in the tonsils and base of the tongue. Over 70% of oropharyngeal cancers are now thought to be associated with oncogenic HPV infection. Immunohistochemistry for p16 protein is often used as a surrogate marker for oncogenic HPV in the oropharyngeal tissues, although alternative HPV DNA testing methods are under intensive study...
December 2015: Seminars in Cutaneous Medicine and Surgery
Sue S Yom, Maura L Gillison, Andy M Trotti
No abstract text is available yet for this article.
December 1, 2015: International Journal of Radiation Oncology, Biology, Physics
Lisa Singer, Sue S Yom
Despite the use of systemic therapy and prophylactic cranial irradiation (PCI), outcomes for patients with extensive-stage small cell lung cancer (ES-SCLC) remain poor. Consolidative radiation therapy (RT) to the chest may improve outcomes by improving local control. In a recently completed multi-institutional phase III clinical trial, investigators randomized patients with ES-SCLC and response to chemotherapy to PCI with or without consolidative RT. Two-year overall survival (OS) and 6-month progression-free survival (PFS) were improved with the use of consolidative RT; however, the prognosis for ES-SCLC in the experimental arm was still poor and there was no statistically significantly difference in 1-year OS, the trial's primary endpoint...
June 2015: Translational Lung Cancer Research
David G Pfister, Sharon Spencer, David M Brizel, Barbara Burtness, Paul M Busse, Jimmy J Caudell, Anthony J Cmelak, A Dimitrios Colevas, Frank Dunphy, David W Eisele, Robert L Foote, Jill Gilbert, Maura L Gillison, Robert I Haddad, Bruce H Haughey, Wesley L Hicks, Ying J Hitchcock, Antonio Jimeno, Merrill S Kies, William M Lydiatt, Ellie Maghami, Thomas McCaffrey, Loren K Mell, Bharat B Mittal, Harlan A Pinto, John A Ridge, Cristina P Rodriguez, Sandeep Samant, Jatin P Shah, Randal S Weber, Gregory T Wolf, Frank Worden, Sue S Yom, Nicole McMillian, Miranda Hughes
These NCCN Guidelines Insights focus on recent updates to the 2015 NCCN Guidelines for Head and Neck (H&N) Cancers. These Insights describe the different types of particle therapy that may be used to treat H&N cancers, in contrast to traditional radiation therapy (RT) with photons (x-ray). Research is ongoing regarding the different types of particle therapy, including protons and carbon ions, with the goals of reducing the long-term side effects from RT and improving the therapeutic index. For the 2015 update, the NCCN H&N Cancers Panel agreed to delete recommendations for neutron therapy for salivary gland cancers, because of its limited availability, which has decreased over the past 2 decades; the small number of patients in the United States who currently receive this treatment; and concerns that the toxicity of neutron therapy may offset potential disease control advantages...
July 2015: Journal of the National Comprehensive Cancer Network: JNCCN
Shirin M Hemmat, Steven J Wang, Alina Uzelac, Sue S Yom, William R Ryan
BACKGROUND/AIMS: To determine the utility of head and neck magnetic resonance imaging (HN-MRI) for the routine surveillance of patients without concurrent symptoms or signs of recurrence more than 6 months after treatment for salivary gland carcinoma (SGC). METHODS: This is a retrospective single-institution review of SGC patients from 2000 to 2011 who underwent one or more HN-MRI scans without concurrent suspicious symptoms or signs of recurrence more than 6 months after the completion of treatment, with at least 6 months of follow-up after each scan...
2015: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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