Francesco Emma, Carla Pizzini, Alessandra Tessa, Silvia Di Giandomenico, Andrea Onetti-Muda, Filippo M Santorelli, Enrico Bertini, Gianfranco Rizzoni
Kearns-Sayre syndrome (KSS) is a mitochondrial disease caused by large deletions in mitochondrial DNA (mtDNA). In most patients the disease is characterized by mtDNA heteroplasmy, where a mixture of wild-type and mutated mtDNA co-exist within cells in variable proportion, modulating the severity of the phenotype in different tissues. We report on the case of a 14-year-old child with classical symptoms of KSS and a renal phenotype characterized by hypokalaemic alkalosis, hypomagnesaemia, hyperreninaemia, hyperaldosteronism and nephrocalcinosis, resembling Bartter syndrome...
March 2006: Pediatric Nephrology