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https://www.readbyqxmd.com/read/29453683/flow-energy-loss-as-a-predictive-parameter-for-right-ventricular-deterioration-caused-by-pulmonary-regurgitation-after-tetralogy-of-fallot-repair
#1
Miyuki Shibata, Keiichi Itatani, Taiyu Hayashi, Takashi Honda, Atsushi Kitagawa, Kagami Miyaji, Minoru Ono
The optimal timing for pulmonary valve replacement after Tetralogy of Fallot (TOF) repair remains controversial. In this study, we estimated the feasibility of using flow energy loss (FEL) to predict right ventricular (RV) deterioration due to pulmonary regurgitation after TOF repair. We examined RV outflow tract (RVOT) flow in nine patients who underwent TOF or double-outlet right ventricle repair in the intervention group (Group I) and compared them with three healthy children in the control group (Group C)...
February 16, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29453634/comparison-of-serological-and-molecular-typing-methods-for-epidemiological-investigation-of-tenacibaculum-species-pathogenic-for-fish
#2
Clara Fernández-Álvarez, Yolanda Torres-Corral, Ysabel Santos
In the present study, the potential of serological methods, the repetitive extragenic palindromic PCR (REP-PCR) and the enterobacterial repetitive intergenic consensus sequence PCR (ERIC-PCR) for the typing of the species Tenacibaculum maritimum, Tenacibaculum soleae and Tenacibaculum discolor was evaluated. Moreover, molecular and proteomic techniques were used to assess variability among strains belonging to different serotypes, as well as isolated from different host species and geographical areas. Slide agglutination and dot-blot assays demonstrated the lack of immunological relationships among Tenacibaculum species analyzed...
February 16, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29452212/exploring-in-vivo-metabolism-and-excretion-of-qo-58l-using-ultra-high-performance-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#3
Jiaqi Zhang, Qingzhong Jia, Jinlong Qi, Hailin Zhang, Yaru Wu, Xiaowei Shi
QO-58 lysine (QO-58L) as a new potassium channel opener, reported to have a potential activity to cure neuropathic pain. The aim of this research is to develop and validate a high-performance liquid chromatography with tandem spectrometry (LC-MS/MS) method for the quantification of QO-58L in rat urine, feces and bile. In addition, analyze and identify the metabolites in urine and bile. The assay for this compound in samples detected with multiple reaction monitoring mode (MRM), and take nimodipine as internal standards (IS)...
February 13, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29451890/detection-of-bartonella-spp-in-fleas-by-maldi-tof-ms
#4
Basma El Hamzaoui, Maureen Laroche, Lionel Almeras, Jean Michel Bérenger, Didier Raoult, Philippe Parola
BACKGROUND: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has recently emerged in the field of entomology as a promising method for the identification of arthropods and the detection of associated pathogens. METHODOLOGY/PRINCIPAL FINDINGS: An experimental model of Ctenocephalides felis (cat fleas) infected with Bartonella quintana and Bartonella henselae was developed to evaluate the efficacy of MALDI-TOF MS in distinguishing infected from uninfected fleas, and its ability to distinguish fleas infected with Bartonella quintana from fleas infected with Bartonella henselae...
February 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29451294/quantification-of-isomerically-summed-hydrocarbon-contributions-to-crude-oil-by-carbon-number-double-bond-equivalent-and-aromaticity-using-gas-chromatography-with-tunable-vacuum-ultraviolet-ionization
#5
Jeremy A Nowak, Robert J Weber, Allen H Goldstein
The ability to structurally characterize and isomerically quantify crude oil hydrocarbons relevant to refined fuels such as motor oil, diesel, and gasoline represents an extreme challenge for chromatographic and mass spectrometric techniques. This work incorporates two-dimensional gas chromatography coupled to a tunable vacuum ultraviolet soft photoionization source, the Chemical Dynamics Beamline 9.0.2 of the Advanced Light Source at the Lawrence Berkeley National Laboratory, with a time-of-flight mass spectrometer (GC × GC-VUV-TOF) to directly characterize and isomerically sum the contributions of aromatic and aliphatic species to hydrocarbon classes of four crude oils...
February 16, 2018: Analyst
https://www.readbyqxmd.com/read/29449446/improving-accuracy-of-simultaneously-reconstructed-activity-and-attenuation-maps-using-deep-learning
#6
Donghwi Hwang, Kyeong Yun Kim, Seung Kwan Kang, Seongho Seo, Jin Chul Paeng, Dong Soo Lee, Jae Sung Lee
Simultaneous reconstruction of activity and attenuation using the maximum likelihood reconstruction of activity and attenuation (MLAA) augmented by time-of-flight (TOF) information is a promising method for positron emission tomography (PET) attenuation correction. However, it still suffers from several problems, including crosstalk artifacts, slow convergence speed, and noisy attenuation maps (μ-maps). In this work, we developed deep convolutional neural networks (CNNs) to overcome these MLAA limitations, and we verified their feasibility using a clinical brain PET data set...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29449445/evaluation-of-penalized-likelihood-estimation-reconstruction-on-a-digital-time-of-flight-pet-ct-scanner-for-18-f-fdg-whole-body-examinations
#7
Elin Lindström, Anders Sundin, Carlos Trampal, Lars Lindsjö, Ezgi Ilan, Torsten Danfors, Gunnar Antoni, Jens Sörensen, Mark Lubberink
Resolution and quantitative accuracy of positron emission tomography (PET) are highly influenced by the reconstruction method. Penalized likelihood estimation algorithms allow for fully convergent iterative reconstruction, generating a higher image contrast while limiting noise compared to ordered subsets expectation maximization (OSEM). In this study, block-sequential regularized expectation maximization (BSREM) was compared to time-of-flight OSEM (TOF-OSEM). Various strengths of noise penalization factor β were tested along with scan durations and transaxial field of views (FOVs) with the aim to evaluate the performance and clinical use of BSREM for 18 F-FDG-PET-computed tomography (CT), both in quantitative terms and in a qualitative visual evaluation...
February 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29448996/automating-data-analysis-for-two-dimensional-gas-chromatography-time-of-flight-mass-spectrometry-non-targeted-analysis-of-comparative-samples
#8
Ivan A Titaley, O Maduka Ogba, Leah Chibwe, Eunha Hoh, Paul H-Y Cheong, Staci L Massey Simonich
Non-targeted analysis of environmental samples, using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC/ToF-MS), poses significant data analysis challenges due to the large number of possible analytes. Non-targeted data analysis of complex mixtures is prone to human bias and is laborious, particularly for comparative environmental samples such as contaminated soil pre- and post-bioremediation. To address this research bottleneck, we developed OCTpy, a Python™ script that acts as a data reduction filter to automate GC × GC/ToF-MS data analysis from LECO ® ChromaTOF ® software and facilitates selection of analytes of interest based on peak area comparison between comparative samples...
February 7, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29448716/templated-growth-of-pd-nanoparticles-using-sputtering-deposition-process-and-its-catalytic-activities
#9
Dario Eberhardt, Pedro Migowski, Sérgio R Teixeira, Adriano F Feil
A simple method based on sputtering deposition of Pd onto mesoporous SiO2 (SBA-15) was employed to produce supported Pd nanoparticles (NPs) that can be used as hydrogenation catalysts. The use of sputtering deposition eliminates contaminants and avoids additional drawbacks of traditional chemical methods applied to prepare heterogeneous supported metal catalysts. A mechanical resonant stirrer was used to revolve the SBA-15 powder and ensure homogeneous distribution of the Pd NPs over the support. The SBA-15 pores act as templates for Pd NPs and drive nanostructure growth...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29448650/synthesis-spectral-and-photophysical-properties-of-anthracene-substituted-phthalocyanines-a-study-as-polyurethane-electrospun-nanofibers
#10
Kyo-Sun Ku, Rangaraju Satish Kumar, Young-A Son
We have designed and synthesized novel symmetrical anthracene substituted zinc(II), copper(II), cobalt(II) and nickel(II) phthalocyanines (PC1, PC2, PC3 and PC4) in this work. For this synthesis, we started from base-catalysed aromatic displacement reaction of 4-nitrophthalonitrile with 9-hydroxyanthracene. The resulting four phthalocyanines (PCs) have been fully characterized by a series of spectroscopic methods including electronic absorption, elemental analysis, MALDI-TOF mass, and IR spectroscopy. The aggregation behavior of these PCs was investigated in different concentrations of chloroform solution...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447904/intraspecific-venom-variation-in-southern-african-scorpion-species-of-the-genera-parabuthus-uroplectes-and-opistophthalmus-scorpiones-buthidae-scorpionidae
#11
Stephan Schaffrath, Lorenzo Prendini, Reinhard Predel
Scorpion venoms comprise cocktails of proteins, peptides, and other molecules used for immobilizing prey and deterring predators. The composition and efficacy of scorpion venoms appears to be taxon-specific due to a coevolutionary arms race with prey and predators that adapt at the molecular level. The taxon-specific components of scorpion venoms can be used as barcodes for species identification if the amount of intraspecific variation is low and the analytical method is fast, inexpensive and reliable. The present study assessed the extent of intraspecific variation in newly regenerated venom collected in the field from geographically separated populations of four southern African scorpion species: three buthids, Parabuthus granulatus (Ehrenberg, 1831), Uroplectes otjimbinguensis (Karsch, 1879), and Uroplectes planimanus (Karsch, 1879), and one scorpionid, Opistophthalmus carinatus (Peters, 1861)...
February 12, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29446650/methods-for-culturing-anaerobes-from-human-specimen
#12
Elodie Guilhot, Saber Khelaifia, Bernard La Scola, Didier Raoult, Grégory Dubourg
Anaerobes represent the dominating population in the human gut microbiota and play a key role in gut homeostasis. In addition, several anaerobes are now considered as probiotics and they remain essential to several processes in the field of biotechnology. With the implementation of MALDI-TOF MS in routine laboratories, anaerobes are no longer neglected in clinical microbiology, as their identification is made easy. However, the isolation and identification of anaerobic bacteria, remains time consuming, fastidious and costly...
February 15, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29446621/oxidative-dehydrogenation-on-nanocarbon-insights-into-the-reaction-mechanism-and-kinetics-via-in-situ-experimental-methods
#13
Wei Qi, Pengqiang Yan, Dang Sheng Su
Sustainable and environmentally benign catalytic processes are vital for the future to supply the world population with clean energy and industrial products. The replacement of conventional metal or metal oxide catalysts with earth abundant and renewable nonmetallic materials has attracted considerable research interests in the field of catalysis and material science. The stable and efficient catalytic performance of nanocarbon materials was discovered at the end of last century, and these materials are considered as potential alternatives for conventional metal-based catalysts...
February 15, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29446487/tm2d3-rs675436-or-fgfr2-rs755793-polymorphisms-and-susceptibility-to-epstein-barr-virus-associated-tumors-in-chinese-han-population
#14
Qianqian Zhang, Wen Liu, Yang Yang, Zhenzhen Zhao, Bing Luo
BACKGROUND: Epstein-Barr virus (EBV) is etiologically linked to nasopharyngeal carcinoma, lymphoma and gastric carcinoma. The aim of this study was to assess the association of TM2 domain containing 3 (TM2D3) and fibroblast growth factor receptor 2 (FGFR2) SNPs rs675436 and rs755793 with susceptibility to EBV-associated tumors in Chinese Han population. MATERIALS AND METHODS: Genomic DNA of 415 patients with cancer and 99 healthy controls was assessed using a MALDI-TOF mass spectrometer, and was genotyped in EBV-associated/-negative gastric cancer (EBVa/nGC), EBV-associated/-negative nasopharyngeal carcinoma (EBVa/nNPC), EBV-associated/ -negative lymphoma (EBVa/nL) and normal controls (NC)...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29445834/the-combination-of-2-5-dihydroxybenzoic-acid-and-2-5-dihydroxyacetophenone-matrices-for-unequivocal-assignment-of-phosphatidylethanolamine-species-in-complex-mixtures
#15
Jenny Schröter, Annabelle Fülöp, Carsten Hopf, Jürgen Schiller
Unequivocal assignment of phospholipid peaks in complex mixtures is difficult if only the m/z values but no tandem mass spectrometry (MS/MS) data are available. This is usually the case for matrix-assisted laser/desorption ionization time-of-flight (MALDI-TOF) MS imaging experiments and the analysis has normally to be performed without prior separation. Another problem might be the often matrix-induced loss of one methyl group in phosphatidylcholine (PC) species, which makes them detectable as negative ions becoming isomers of some phosphatidylethanolamines (PEs)...
February 14, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29445382/innovative-approaches-to-evaluate-sugar-beet-responses-to-changes-in-sulfate-availability
#16
Piergiorgio Stevanato, Chiara Broccanello, Vita M C Moliterni, Giuseppe Mandolino, Valeria Barone, Luigi Lucini, Giovanni Bertoldo, Marco Bertaggia, Massimo Cagnin, Diego Pizzeghello, Andrea Baglieri, Andrea Squartini, Giuseppe Concheri, Serenella Nardi
In this study, a system based on omics profiling was set-up for sugar beet ( Beta vulgaris L. subsp. vulgaris ) evaluation after changes in sulfate availability. Seedlings were grown on sulfate-deprived Hoagland solution. Six days after germination, 100 μM MgSO 4 was added to the solution. Root samples were collected 36 h after treatments. WinRHIZO root-scanning approach was used for the automated image analysis of plant root morphology. Inductively Coupled Plasma Spectrometry (ICP-OES) and quadrupole-time-of-flight mass spectrometry (Q-TOF) were used for ionomic and metabolic analysis, respectively...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29444330/increased-species-assignment-of-filamentous-fungi-using-maldi-tof-ms-coupled-with-a-simplified-sample-processing-and-an-in-house-library
#17
M E Zvezdanova, P Escribano, A Ruiz, M C Martínez-Jiménez, T Peláez, A Collazos, J Guinea, E Bouza, B Rodríguez-Sánchez
In this study we evaluated the capacity of MALDI-TOF MS (Bruker Daltonics, Bremen, Germany) to identify clinical mould isolates. We focused on two aspects of MALDI-TOF MS identification: the sample processing and the database. Direct smearing of the sample was compared with a simplified processing consisting of mechanical lysis of the moulds followed by a protein extraction step. Both methods were applied to all isolates and the Filamentous Fungi Library 1.0 (Bruker Daltonics) was used for their identification...
February 9, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29442820/synthesis-optical-electrochemical-and-theoretical-studies-of-new-multicyclic-substituted-phthalocyanines
#18
Changkyeom Kim, Rangaraju Satish Kumar, Naveen Mergu, Kun Jun, Young-A Son
Here novel phenanthrenoxy and pyrenoxy substituted phthalocyanines were synthesized and fully characterized by general spectroscopic methods such as elemental analysis, 1H NMR, MALDI-TOF, FT-IR, UV-Visible absorption. The aggregation property of these phthalocyanines was investigated in CHCl3 and Triton X. Furthermore, electrochemical and DFT calculations were performed for these molecules.
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442027/the-effect-of-slco1b1-polymorphism-on-the-pharmacokinetics-of-atorvastatin-and-2-hydroxyatorvastatin-in-healthy-chinese-people
#19
Yaqin Wang, Yingying Tian, Peiyu Lv, Lulu Chen, Wei Luo, Xian Jing, Hui Li, Zhirong Tan, Yicheng Wang, Honghao Zhou, Dong-Sheng Ouyang
The pharmacokinetics of statins show substantial inter-subject variability. Increasing systemic exposure of statins may lead to adverse drug reactions such as myopathy. The variation in statin pharmacokinetics is partly explained by genetic factors. OATP1B1, coded by SLCO1B1 transports a large number of therapeutic drugs, such as atorvastatin. Here we investigated the effect of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and its metabolites. Two pharmacokinetic studies were conducted in Chinese Han volunteers and 132 volunteers were enrolled in our study as 72 in trial 1 and 60 in trial 2...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441626/identification-of-metabolites-of-anticancer-candidate-salinomycin-using-liquid-chromatography-coupled-with-q-tof-and-hybrid-qqq-linear-ion-trap-mass-spectrometry
#20
Małgorzata Olejnik, Lidia Radko, Piotr Jedziniak
RATIONALE: Salinomycin is an ionophore antibiotic with potential anti-cancer activity. The history of its use in veterinary medicine show large differences in species susceptibility to its toxicity. At the same time, the results of so-far research suggest the correlation between the extent and pathways of ionophore biotransformation and its toxicity. The biotransformation pattern of salinomycin has not been studied so far. METHODS: The extracts from culture media of human hepatoma cells (HepG2) exposed to salinomycin were analysed with two mass spectrometry techniques...
February 14, 2018: Rapid Communications in Mass Spectrometry: RCM
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