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Khushboo N Parikh, Nishant C Shah, Joseph B Clark, John L Myers
Chronic pulmonary insufficiency following transannular patch repair of tetralogy of Fallot may mandate restoration of a competent pulmonary valve. Pulmonary valve leaflets that are preserved at initial surgery may grow and develop normal morphology and subsequent valve repair may be possible. We reviewed our experience with native pulmonary valve restitution following transannular patch repair (2001-15). The cohort included 9 patients with a median age of 18.7 (range 10.6-31.3) years. Operative technique involved reapproximation of the anterior commissure of the pulmonary valve...
June 26, 2017: Interactive Cardiovascular and Thoracic Surgery
Feng Zhu, Wenliang Ji, Hualiang Liu, Yanbo Jia, Mei Cai, Hao Zhang
A method was developed for the screening and detection of food poisonings by ultra high performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UHPLC-Q-TOF MS). After extracted by acetonitrile and cleaned-up by QuEChERS, the extract was separated on a Waters Acquity UPLC BEH C18 column (100 mm×2.1 mm, 1.7 μm) with the gradient elution of 0.1% (v/v) formic acid in water and 0.1% (v/v) formic acid in acetonitrile. TOF-MS scan-information dependent acquisition (IDA)-product ion scan was performed in positive electrospray ionization (ESI) mode to acquire high resolution MS and MS/MS spectra in one injection, and rapidly screen 581 target compounds by SCIEX OS software, including 546 pesticides, 24 mycotoxins, 11 rodenticides...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
Yongqiang Liu, Sheng Liu, Wenjuan Xu, Guoning Tian, Jinling Zhang
An analytical method was established for the simultaneous determination of 44 pesticide residues in ginger and scallion by ultra performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry (UPLC-Q-TOF/MS). The samples were extracted with acetonitrile containing 0.1% (v/v) acetic acid aqueous solution, and cleaned-up by primary secondary amine (PSA) and octadecyl bonded silica (C18) adsorbents. The compounds were separated on a Poroshell 120 SB-C18 column (100 mm×3.0 mm, 2.7 μm) with 0...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
Hongwei Wang, Zhongshan Liu, Xiaojun Peng, Junjie Ou, Mingliang Ye
An acylsemicarbazide-based porous organic polymer (POP) was facilely prepared by the polymerization of benzene-1,3,5-tricarbohydrazide (BTZ) and 1,4-phenylene diisocyanate (PDI). The physical properties of as-synthesized material were characterized by Fourier-transform infrared spectroscopy (FT-IR), solid-state cross polarisation magic angle spinning carbon-13 nuclear magnetic resonance (CP-MAS (13)C NMR), nitrogen adsorption/desorption measurement, water contact angle and so on. The specific surface area was 166 m(2)/g, and the water contact angle was 46...
July 8, 2017: Se Pu, Chinese Journal of Chromatography
Xiujin Zhou, Yu Chen, Saijun Yang, Honghong Shao, Biao Shen, Shun'an Zhan
A fast sample pretreatment method by fast pesticide extraction (FaPEx) method combined with ultra-performance liquid chromatography-quadrupole-time of flight mass spectrometry was developed for screening of unknown pesticide residues in imported grains. The samples were extracted with 1% (v/v) acetic acid acetonitrile solution, cleaned-up by solid phase extraction column with FaPEx cartridges, and determined by UPLC-Q-TOF. The data was compared with the library with the accurate mass, isotopic distribution, fragmentation information and retention time...
August 8, 2017: Se Pu, Chinese Journal of Chromatography
Rashanique D Quarels, Xianglin Zhai, Neepa Kuruppu, Jenny K Hedlund, Ashley A Ellsworth, Amy V Walker, Jayne C Garno, Justin R Ragains
Visible-light irradiation of phthalimide esters in the presence of the photosensitizer [Ru(bpy)3](2+) and the stoichiometric reducing agent benzyl nicotinamide results in the formation of alkyl radicals under mild conditions. This approach to radical generation has proven useful for the synthesis of small organic molecules. Herein, we demonstrate for the first time the visible-light photosensitized deposition of robust alkyl thin films on Au surfaces using phthalimide esters as the alkyl radical precursors...
2017: Beilstein Journal of Nanotechnology
Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming, Jürgen Janek
BACKGROUND: Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of specially designed titanium-niobium (Ti-40Nb) implant alloy would provide an advanced implant system that is mechanically adapted to altered bone with the ability to stimulate bone formation...
2017: Biomaterials Research
Ari Morgenthau, William H Frishman
Due to improved survival and clinical outcomes, congenital heart disease is an area of growing importance within the medical community. As these patients reach adulthood and have children, there has been a growing appreciation for the increased risk of CHD among their offspring, strongly implying a genetic element. Given the growing wealth of genetic data available and these clinical implications, this review serves to re-examine the role of genetics within CHD, using Tetralogy of Fallot as a model pathology...
October 17, 2017: Cardiology in Review
A Caesar, S Meyer, N Trost, K Neuenschwander, C Geisen, B M Frey, C Gassner, P Schwind
BACKGROUND AND OBJECTIVES: A lateral flow assay for simultaneous blood group typing of ABO, RhD, C, E, c, e, Cw and K with stable end-point and without centrifugation is in routine use since several years (MDmulticard(®) ). The typing of extended phenotype parameters belonging to the Duffy, Kidd, MNSs blood group systems and others, however, has not yet been demonstrated for this technique. Reliable detection of Fy(x) , a weak Fy(b) phenotype with a pronounced quantitative reduction of the number of Fy(b) antigens on the erythrocyte surface, remains a weakness of current serological blood grouping techniques...
October 16, 2017: Vox Sanguinis
Jian Jin, Can Zhong, You Qin, Yuan Cai, Lanping Zhen, Bingbing Shen, Lin Chen, Dan Wan, Yuhui Qin, Shuihan Zhang
Caterpillar fungi have numerous pharmacological and therapeutic applications in traditional medicine, due to a variety of active chemical constituents, such as cordycepin and adenosine. It is imperative to discover new resource for artificial cultivation and biometabolite production since the traditional natural species are endangered. In this study, a new strain HACM 001 was isolated and identified as Ophiocordyceps xuefengensis by rDNA-ITS sequencing. This strain showed the potential of artificial infection to caterpillar larvae leading to mummification, as well as fermentation mycelia in liquid culture and cultivation stromata in solid medium...
November 1, 2017: FEMS Microbiology Letters
E C Schwalbe, D Hicks, G Rafiee, M Bashton, H Gohlke, A Enshaei, S Potluri, J Matthiesen, M Mather, P Taleongpong, R Chaston, A Silmon, A Curtis, J C Lindsey, S Crosier, A J Smith, T Goschzik, F Doz, S Rutkowski, B Lannering, T Pietsch, S Bailey, D Williamson, S C Clifford
Rapid and reliable detection of disease-associated DNA methylation patterns has major potential to advance molecular diagnostics and underpin research investigations. We describe the development and validation of minimal methylation classifier (MIMIC), combining CpG signature design from genome-wide datasets, multiplex-PCR and detection by single-base extension and MALDI-TOF mass spectrometry, in a novel method to assess multi-locus DNA methylation profiles within routine clinically-applicable assays. We illustrate the application of MIMIC to successfully identify the methylation-dependent diagnostic molecular subgroups of medulloblastoma (the most common malignant childhood brain tumour), using scant/low-quality samples remaining from the most recently completed pan-European medulloblastoma clinical trial, refractory to analysis by conventional genome-wide DNA methylation analysis...
October 18, 2017: Scientific Reports
Karunamay Majee, Jully Patel, Babulal Das, Sumanta Kumar Padhi
The binuclear copper complex [Cu(DQPD)]2 (where DQPD = deprotonated N(2),N(6)-di(quinolin-8-yl)pyridine-2,6-dicarboxamide (DQPDH2)) was synthesised and characterised by various spectroscopic as well as electrochemical techniques. The binuclear copper complex was converted into a mononuclear one by the addition of 2 equivalents of pTsOH into [Cu(DQPD)]2. The interconversion between the dimer and monomer complex was studied through UV-Vis spectroscopy and cyclic voltammetry. The mononuclear copper complex showed high catalytic activity towards electrochemical proton reduction using acetic acid as the external proton source in 95 : 5 (v/v) DMF/H2O...
October 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Sven Pletincx, Kristof Marcoen, Lena Trotochaud, Laura-Lynn Fockaert, Johannes M C Mol, Ashley R Head, Osman Karslioğlu, Hendrik Bluhm, Herman Terryn, Tom Hauffman
Understanding the stability of chemical interactions at the polymer/metal oxide interface under humid conditions is vital to understand the long-term durability of hybrid systems. Therefore, the interface of ultrathin PMMA films on native aluminum oxide, deposited by reactive adsorption, was studied. The characterization of the interface of the coated substrates was performed using ambient pressure X-ray photoelectron spectroscopy (APXPS), Fourier transform infrared spectroscopy in the Kretschmann geometry (ATR-FTIR Kretschmann) and time-of-flight secondary ion mass spectrometry (ToF-SIMS)...
October 17, 2017: Scientific Reports
Xing Lu, Shuangyou Zhang, Xing Chen, Dohyeon Kwon, Chan-Gi Jeon, Zhigang Zhang, Jungwon Kim, Kebin Shi
Ultrahigh-resolution optical strain sensors provide powerful tools in various scientific and engineering fields, ranging from long-baseline interferometers to civil and aerospace industries. Here we demonstrate an ultrahigh-resolution fibre strain sensing method by directly detecting the time-of-flight (TOF) change of the optical pulse train generated from a free-running passively mode-locked laser (MLL) frequency comb. We achieved a local strain resolution of 18 pε/Hz(1/2) and 1.9 pε/Hz(1/2) at 1 Hz and 3 kHz, respectively, with large dynamic range of >154 dB at 3 kHz...
October 17, 2017: Scientific Reports
Bin Jiang, Xiaoqing Zhang, Yongqiang Yuan, Yuxiao Qu, Zhibiao Feng
An aqueous two-phase system (ATPS) consisting of poly(ethylene glycol-ran-propylene glycol) monobutyl ether (UCON)/phosphate was developed for the separation of the antioxidant peptides from pepsin hydrolysate of Whey Protein Isolate (WPI). The efficiency of the separation was evaluated based on the DPPH radical scavenging activity, ABTS radical scavenging activity and ferric reducing antioxidant power (FRAP) of the separated peptides. The effects of some parameters on the partition of antioxidant peptides were investigated...
October 17, 2017: Scientific Reports
Massilia Yousfi, Abdelaziz Touati, Anaelle Muggeo, Brazane Mira, Asma Bourouis, Lucien Brasme, Thomas Guillard, Christophe de Champs
OBJECTIVES: The aim of this study was to investigate carbapenemase-producing Enterobacteriaceae (CPE) in companion animals. METHODS: Between October 2015 and April 2016, 533 rectal swabs were obtained from healthy and diseased pets in different cities in Algeria. Samples collected were plated on MacConkey agar supplemented with ertapenem (0.5mg/L). The isolates were identified by MALDI-TOF mass spectroscopy. Antimicrobial susceptibility testing was performed using disk diffusion method...
October 14, 2017: Journal of Global Antimicrobial Resistance
Skyler Wheaton, Alireza Bonakdar, Iman Hassani Nia, Chee Leong Tan, Vala Fathipour, Hooman Mohseni
In the past two decades 3-D cameras have proven to be one of the next revolutions in machine vision. However, these devices are still an emerging technology with a particularly narrow set of commercially available devices. In this paper, the concept and execution of the first short wavelength infrared (SWIR) time-of-flight (ToF) 3-D camera system operating at a wavelength of 1550 nm is presented. By decoupling the optical and electrical components of the system in an open architecture we not only surpass many of the limitations of an on-chip integrated solution, but also can easily change the imaging device based on the requirements of the application...
August 7, 2017: Optics Express
Xavier Domingo-Almenara, J Rafael Montenegro-Burke, H Paul Benton, Gary Siuzdak
The aim of any untargeted metabolomics experiment is to identify and quantify dysregulated compounds relevant to a particular disease or stressor. However, metabolite identification is still considered an imposing bottleneck in untargeted metabolomics. Untargeted data analysis workflows for liquid chromatography/electrospray ionization/mass spectrometry (LC/ESI/MS) usually consist in applying peak-picking algorithms, align those peaks across multiple samples to obtain the so-called peak features (defined as a peak, or a set of aligned peaks across samples with a unique \textit{m/z} and a specific retention time), and subsequently discover statistically significant variations between experimental groups or conditions...
October 17, 2017: Analytical Chemistry
Yu-Heng Wang, Michael L Pegis, James M Mayer, Shannon S Stahl
A series of mononuclear pseudo-macrocyclic cobalt complexes have been investigated as catalysts for O2 reduction. Each of these complexes, with CoIII/II reduction potentials that span nearly 400 mV, mediate highly selective two-electron reduction of O2 to H2O2 (93-99%) using decamethylferrocene (Fc*) as the reductant and acetic acid as the proton source. Kinetic studies reveal that the rate exhibits a first-order dependence on [Co] and [AcOH], but no dependence on [O2] or [Fc*]. A linear correlation is observed between log(TOF) vs...
October 17, 2017: Journal of the American Chemical Society
Xiaolu Li, Hongming Wang, Bingwei Yang, Jiayue Huyan, Lijun Xu
A pulsed time-of-flight (TOF) measurement-based Light Detection and Ranging (LiDAR) system is more effective for medium-long range distances. As a key ranging unit, a time-pickoff circuit based on automatic gain control (AGC) and constant fraction discriminator (CFD) is designed to reduce the walk error and the timing jitter for obtaining the accurate time interval. Compared with Cramer-Rao lower bound (CRLB) and the estimation of the timing jitter, four parameters-based Monte Carlo simulations are established to show how the range precision is influenced by the parameters, including pulse amplitude, pulse width, attenuation fraction and delay time of the CFD...
October 17, 2017: Sensors
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