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https://www.readbyqxmd.com/read/29133695/manganese-manganism-and-other-neurodegenerative-diseases-is-it-a-cause-of-concern
#1
Imran Rizvi, Ravindra Kumar Garg, Hardeep Singh Malhotra, Neeraj Kumar, Ravi Uniyal
No abstract text is available yet for this article.
November 2017: Neurology India
https://www.readbyqxmd.com/read/29133694/manganese-in-manganism-parkinson-s-disease-huntington-s-disease-amyotrophic-lateral-sclerosis-and-batten-disease-a-narrative-review
#2
REVIEW
Owen Proudfoot
The collective evidence to date suggests that environmental exposure to excessive amounts of manganese (Mn) can cause a neurodegenerative condition known as manganism. It is now also relatively clear that Mn is involved in the pathogenesis of Alzheimer's disease and at least some prion diseases. The potential involvement of Mn in a panel of other neurodegenerative conditions including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and Batten disease has been suggested and investigated, but the results to date are somewhat inconclusive...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29120985/the-influence-of-team-rating-on-running-performance-in-elite-gaelic-football
#3
Shane Mangan, Shane Malone, Martin Ryan, Jason Mc Gahan, Joe Warne, Denise Martin, Cian O'Neill, Con Burns, Kieran Collins
It is currently unknown how team rating influences running performance in Gaelic football. GPS technologies were used to quantify match-running performance within 5 elite Gaelic football teams over a period of 5 years (2012-2016). In total 780 player data sets were collected over 95 matches. Running performance variables included total distance, high-speed distance (≥17 km h) and the percentage of high-speed distance. Team ratings were determined objectively using the Elo Ratings System for Gaelic football...
November 6, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29065245/mangankomplexe-in-der-de-hydrier-katalyse-ein-vergleich-mit-kobalt-und-eisenkatalysatoren
#4
Rhett Kempe, Fabian Kallmeier
Der nachhaltige Umgang mit den Ressourcen unseres Planeten ist essentiell. Edelmetalle sind sehr selten und werden vielfältig in Schlüsseltechnologien genutzt, zu denen insbesondere die Katalyse zählt. Mangan ist das dritthäufigste Übergangsmetall der Erdkruste und aufgrund seiner kürzlich entdeckten beeindruckenden Reaktivität für Hydrier- und Dehydrierreaktionen ein potenziell geeigneter "Edelmetallersatz". An einen derartigen "Ersatz" sind auch Hoffnungen auf neuartige, durch Edelmetalle nicht vermittelbare, Selektivitätsprofile geknüpft...
October 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29046378/fluctuating-seawater-ph-pco2-regimes-are-more-energetically-expensive-than-static-ph-pco2-levels-in-the-mussel-mytilus-edulis
#5
Stephanie Mangan, Mauricio A Urbina, Helen S Findlay, Rod W Wilson, Ceri Lewis
Ocean acidification (OA) studies typically use stable open-ocean pH or CO2 values. However, species living within dynamic coastal environments can naturally experience wide fluctuations in abiotic factors, suggesting their responses to stable pH conditions may not be reflective of either present or near-future conditions. Here we investigate the physiological responses of the mussel Mytilus edulis to variable seawater pH conditions over short- (6 h) and medium-term (2 weeks) exposures under both current and near-future OA scenarios...
October 25, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29042516/across-the-tree-of-life-radiation-resistance-is-governed-by-antioxidant-mn-2-gauged-by-paramagnetic-resonance
#6
Ajay Sharma, Elena K Gaidamakova, Olga Grichenko, Vera Y Matrosova, Veronika Hoeke, Polina Klimenkova, Isabel H Conze, Robert P Volpe, Rok Tkavc, Cene Gostinčar, Nina Gunde-Cimerman, Jocelyne DiRuggiero, Igor Shuryak, Andrew Ozarowski, Brian M Hoffman, Michael J Daly
Despite concerted functional genomic efforts to understand the complex phenotype of ionizing radiation (IR) resistance, a genome sequence cannot predict whether a cell is IR-resistant or not. Instead, we report that absorption-display electron paramagnetic resonance (EPR) spectroscopy of nonirradiated cells is highly diagnostic of IR survival and repair efficiency of DNA double-strand breaks (DSBs) caused by exposure to gamma radiation across archaea, bacteria, and eukaryotes, including fungi and human cells...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29032009/potential-for-stem-cell-treatment-in-manganism
#7
Thatiane C de Moura, Szeifoul Afadlal, Alan S Hazell
Development of manganism (also known as manganese neurotoxicity) is a major complication of manganese exposure in which neurological dysfunction is linked to accumulation of the metal in brain. Due to neuronal cell death in basal ganglia structures, particularly the globus pallidus, functional recovery is limited. Bearing a resemblance to Parkinson's disease, effective treatment for manganism is currently limited. However, the rapidly developing field of stem cell research offers new hope for the treatment of illnesses in which neurodegeneration is a major feature...
October 11, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28945732/renal-gi-and-peripheral-nerves-evidence-based-recommendations-for-the-management-of-symptoms-and-care-for-patients-with-multiple-myeloma
#8
Beth Faiman, Deborah Doss, Kathleen Colson, Patricia Mangan, Tracy King, Joseph D Tariman
BACKGROUND: A majority of patients with multiple myeloma experience damage to the kidneys and peripheral nerves either at diagnosis or throughout the disease. Symptoms of diarrhea, nausea, vomiting, or constipation can also occur. Prevention and management of disease- and treatment-related side effects are essential to treatment adherence.
. OBJECTIVES: This article aims to provide insight into prevention and management of organ health-related toxicities and give best practice recommendations for optimal nursing care...
October 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/28932235/zika-virus-congenital-syndrome-experimental-models-and-clinical-aspects
#9
REVIEW
Carolina Manganeli Polonio, Carla Longo de Freitas, Nagela Ghabdan Zanluqui, Jean Pierre Schatzmann Peron
Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC)...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28914791/quercetin-attenuates-manganese-induced-neuroinflammation-by-alleviating-oxidative-stress-through-regulation-of-apoptosis-inos-nf-%C3%AE%C2%BAb-and-ho-1-nrf2-pathways
#10
Entaz Bahar, Ji-Ye Kim, Hyonok Yoon
Manganese (Mn) is an essential trace element required for the development of human body and acts as an enzyme co-factor or activator for various reactions of metabolism. While essential in trace amounts, excessive Mn exposure can result in toxic accumulations in human brain tissue and resulting extrapyramidal symptoms called manganism similar to idiopathic Parkinson's disease (PD). Quercetin (QCT) has been demonstrated to play an important role in altering the progression of neurodegenerative diseases by protecting against oxidative stress...
September 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28910290/bird-use-of-organic-apple-orchards-frugivory-pest-control-and-implications-for-production
#11
Anna M Mangan, Liba Pejchar, Scott J Werner
As the largest terrestrial biomes, crop and pasturelands can have very large positive or negative impacts on biodiversity and human well-being. Understanding how animals use and impact agroecosystems is important for making informed decisions that achieve conservation and production outcomes. Yet, few studies examine the tradeoffs associated with wildlife in agricultural systems. We examined bird use of organic apple orchards as well as how birds influence fruit production positively through control of an economically important insect pest (codling moth (Cydia pomonella)) and negatively through fruit damage...
2017: PloS One
https://www.readbyqxmd.com/read/28890971/quantitative-interpretation-of-impedance-spectroscopy-data-on-porous-lsm-electrodes-using-x-ray-computed-tomography-and-bayesian-model-based-analysis
#12
Giuseppe F Brunello, William K Epting, Juwana de Silva, Paul A Salvador, Shawn Litster, Harry O Finklea, Yueh-Lin Lee, Kirk R Gerdes, David S Mebane
It is broadly understood that strontium-doped lanthanum manganate (LSM) cathodes for solid oxide fuel cells (SOFCs) have two pathways for the reduction of oxygen: a surface-mediated pathway culminating in oxygen incorporation into the electrolyte at the triple-phase boundary (TPB), and a bulk-mediated pathway involving oxygen transfer across the electrode-electrolyte interface. Patterned electrode and thin film experiments have shown that both pathways are active in LSM. Porous electrode geometries more commonly found in SOFCs have not been amenable for precise measurement of active electrode width because of the difficulty in precisely measuring the electrode geometry...
September 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28878554/model-selection-for-dynamical-systems-via-sparse-regression-and-information-criteria
#13
N M Mangan, J N Kutz, S L Brunton, J L Proctor
We develop an algorithm for model selection which allows for the consideration of a combinatorially large number of candidate models governing a dynamical system. The innovation circumvents a disadvantage of standard model selection which typically limits the number of candidate models considered due to the intractability of computing information criteria. Using a recently developed sparse identification of nonlinear dynamics algorithm, the sub-selection of candidate models near the Pareto frontier allows feasible computation of Akaike information criteria (AIC) or Bayes information criteria scores for the remaining candidate models...
August 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28828603/manganese-control-of-glutamate-transporters-gene-expression
#14
Eunsook Lee, Pratap Karki, James Johnson, Peter Hong, Michael Aschner
Manganese (Mn) is an essential trace element, serving as a cofactor for several enzymes involved in various cellular and biochemical reactions in human body. However, chronic overexposure to Mn from occupational or environmental sources induces a neurological disorder, characterized by psychiatric, cognitive, and motor abnormalities, referred to as manganism. Mn-induced neurotoxicity is known to target astrocytes since these cells preferentially accumulate Mn. Astrocytes are the most abundant non-neuronal glial cells in the brain, and they play a critical role in maintaining the optimal glutamate levels to prevent excitotoxic death...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28745487/self-climbed-amorphous-carbon-nanotubes-filled-with-transition-metal-oxide-nanoparticles-for-large-rate-and-long-lifespan-anode-materials-in-lithium-ion-batteries
#15
Shuoyu Li, Yuyi Liu, Peisheng Guo, Chengxin Wang
A composed material of amorphous carbon nanotubes (ACNTs) and encapsulated transition metal oxide (TMOs) nanoparticles was prepared by a common thermophysics effect, which is named the Marangoni effect, and a simple anneal process. The prepared ropy solution would form a Marangoni convection and climb into the channel of anodic aluminum oxide template (AAO) spontaneously. The ingenious design of the preparation method determined a distinctive structure of TMOs nanoparticles with a size of ∼5 nm and amorphous carbon coated outside full in the ACNTs...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28722417/improving-the-carrier-lifetime-of-tin-sulfide-via-prediction-and-mitigation-of-harmful-point-defects
#16
Alex Polizzotti, Alireza Faghaninia, Jeremy R Poindexter, Lea Nienhaus, Vera Steinmann, Robert L Z Hoye, Alexandre Felten, Amjad Deyine, Niall M Mangan, Juan Pablo Correa-Baena, Seong Sik Shin, Shaffiq Jaffer, Moungi G Bawendi, Cynthia Lo, Tonio Buonassisi
Tin monosulfide (SnS) is an emerging thin-film absorber material for photovoltaics. An outstanding challenge is to improve carrier lifetimes to >1 ns, which should enable >10% device efficiencies. However, reported results to date have only demonstrated lifetimes at or below 100 ps. In this study, we employ defect modeling to identify the sulfur vacancy and defects from Fe, Co, and Mo as most recombination-active. We attempt to minimize these defects in crystalline samples through high-purity, sulfur-rich growth and experimentally improve lifetimes to >3 ns, thus achieving our 1 ns goal...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28722018/a-pro-survival-role-for-the-intracellular-granzyme-b-inhibitor-serpinb9-in-natural-killer-cells-during-poxvirus-infection
#17
Matthew S Mangan, Carolina R Melo-Silva, Jennii Luu, Catherina H Bird, Aulikki Koskinen, Alexandra Rizzitelli, Monica Prakash, Katrina L Scarff, Arno Müllbacher, Matthias Regner, Phillip I Bird
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects cells against granzyme B-mediated cell death. Using a knockout mouse line engineered to express green fluorescent protein under the serpbinb9 promoter, we demonstrate that serpinb9 is vital for host survival during Ectromelia virus infection by maintaining both mature natural killer NK) cells, and activated CD8(+) T cells...
August 15, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28721788/integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-miller-robin-brown-hilary-and-mangan-catherine-integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-232pp-%C3%A2-22-99-jessica-kingsley-9781849056465
#18
(no author information available yet)
The blurb of this book suggests it is about leading, managing and delivering integrated care, but it could be applied to any kind of change in healthcare services.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28692648/zebrafish-slc30a10-deficiency-revealed-a-novel-compensatory-mechanism-of-atp2c1-in-maintaining-manganese-homeostasis
#19
Zhidan Xia, Jiayu Wei, Yingniang Li, Jia Wang, Wenwen Li, Kai Wang, Xiaoli Hong, Lu Zhao, Caiyong Chen, Junxia Min, Fudi Wang
Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific treatments are available for this disorder. Here, we generated two zebrafish slc30a10 mutant lines using the CRISPR/Cas9 system. Compared to wild-type animals, mutant adult animals developed significantly higher systemic Mn levels, and Mn accumulated in the brain and liver of mutant embryos in response to exogenous Mn...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28663501/plant-diversity-increases-with-the-strength-of-negative-density-dependence-at-the-global-scale
#20
Joseph A LaManna, Scott A Mangan, Alfonso Alonso, Norman A Bourg, Warren Y Brockelman, Sarayudh Bunyavejchewin, Li-Wan Chang, Jyh-Min Chiang, George B Chuyong, Keith Clay, Richard Condit, Susan Cordell, Stuart J Davies, Tucker J Furniss, Christian P Giardina, I A U Nimal Gunatilleke, C V Savitri Gunatilleke, Fangliang He, Robert W Howe, Stephen P Hubbell, Chang-Fu Hsieh, Faith M Inman-Narahari, David Janík, Daniel J Johnson, David Kenfack, Lisa Korte, Kamil Král, Andrew J Larson, James A Lutz, Sean M McMahon, William J McShea, Hervé R Memiaghe, Anuttara Nathalang, Vojtech Novotny, Perry S Ong, David A Orwig, Rebecca Ostertag, Geoffrey G Parker, Richard P Phillips, Lawren Sack, I-Fang Sun, J Sebastián Tello, Duncan W Thomas, Benjamin L Turner, Dilys M Vela Díaz, Tomáš Vrška, George D Weiblen, Amy Wolf, Sandra Yap, Jonathan A Myers
Theory predicts that higher biodiversity in the tropics is maintained by specialized interactions among plants and their natural enemies that result in conspecific negative density dependence (CNDD). By using more than 3000 species and nearly 2.4 million trees across 24 forest plots worldwide, we show that global patterns in tree species diversity reflect not only stronger CNDD at tropical versus temperate latitudes but also a latitudinal shift in the relationship between CNDD and species abundance. CNDD was stronger for rare species at tropical versus temperate latitudes, potentially causing the persistence of greater numbers of rare species in the tropics...
June 30, 2017: Science
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