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https://www.readbyqxmd.com/read/27914093/lsmo-nanoparticles-coated-by-hyaluronic-acid-for-magnetic-hyperthermia
#1
Yuanwei Chen, Ying Wang, Xi Liu, Mai Lu, Jiangwei Cao, Tao Wang
Magnetic hyperthermia with the treating temperature range of 41-46 °C is an alternative therapy for cancer treatment. In this article, lanthanum strontium manganates (La1-x Sr x MnO3, 0.25 ≤ × ≤ 0.35) magnetic nanoparticles coated by hyaluronic acid (HA) which possesses the ability of targeting tumor cells were prepared by a simple hydrothermal method combined with a high-energy ball milling technique. The crystal structure, morphology, magnetic properties of the HA-coated magnetic nanoparticles (MNPs), and their heating ability under alternating magnetic field were investigated...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27913844/global-dna-methylation-profiling-of-manganese-exposed-human-neuroblastoma-sh-sy5y-cells-reveals-epigenetic-alterations-in-parkinson-s-disease-associated-genes
#2
Prashant Tarale, Saravanadevi Sivanesan, Atul P Daiwile, Reinhard Stöger, Amit Bafana, Pravin K Naoghare, Devendra Parmar, Tapan Chakrabarti, Krishnamurthi Kannan
Manganese (Mn) is an essential trace element required for optimal functioning of cellular biochemical pathways in the central nervous system. Elevated exposure to Mn through environmental and occupational exposure can cause neurotoxic effects resulting in manganism, a condition with clinical symptoms identical to idiopathic Parkinson's disease. Epigenetics is now recognized as a biological mechanism involved in the etiology of various diseases. Here, we investigated the role of DNA methylation alterations induced by chronic Mn (100 µM) exposure in human neuroblastoma (SH-SY5Y) cells in relevance to Parkinson's disease...
December 2, 2016: Archives of Toxicology
https://www.readbyqxmd.com/read/27885631/the-glutamine-transporters-and-their-role-in-the-glutamate-gaba-glutamine-cycle
#3
Renata Leke, Arne Schousboe
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA-glutamine cycle (GGC). In the GGC, glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools. Different transporters participate in this neural communication, i.e., the transporters responsible for glutamine efflux from astrocytes and influx into the neurons, such as the members of the SNAT, LAT, y(+)LAT, and ASC families of transporters. The SNAT family consists of the transporter isoforms SNAT3 and SNAT5 that are related to efflux from the astrocytic compartment, and SNAT1 and SNAT2 that are associated with glutamine uptake into the neuronal compartment...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27870693/limb-salvage-with-intrepid-dynamic-exoskeletal-orthosis-versus-transtibial-amputation-a-comparison-of-functional-gait-outcomes
#4
Katharine I Mangan, Trevor D Kingsbury, Brittney N Mazzone, Marilynn P Wyatt, Kevin M Kuhn
OBJECTIVES: To determine if there is a difference in functional gait outcomes between patients with limb injuries treated with either transtibial amputation or limb preservation with the Intrepid Dynamic Exoskeletal Orthosis. DESIGN: Retrospective prognostic study. SETTING: Tertiary referral military hospital. PATIENTS: This study included 10 transtibial amputees and 10 limb preservation patients using the Intrepid Dynamic Exoskeletal Orthosis who were matched by body mass index after excluding for nontraumatic, proximal ipsilateral, contralateral, spine, or traumatic brain injuries...
December 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27856432/efficacy-and-safety-of-sarilumab-monotherapy-versus-adalimumab-monotherapy-for-the-treatment-of-patients-with-active-rheumatoid-arthritis-monarch-a-randomised-double-blind-parallel-group-phase-iii-trial
#5
Gerd R Burmester, Yong Lin, Rahul Patel, Janet van Adelsberg, Erin K Mangan, Neil M H Graham, Hubert van Hoogstraten, Deborah Bauer, Juan Ignacio Vargas, Eun Bong Lee
OBJECTIVES: To compare efficacy and safety of sarilumab monotherapy with adalimumab monotherapy in patients with active rheumatoid arthritis (RA) who should not continue treatment with methotrexate (MTX) due to intolerance or inadequate response. METHODS: MONARCH was a randomised, active-controlled, double-blind, double-dummy, phase III superiority trial. Patients received sarilumab (200 mg every 2 weeks (q2w)) or adalimumab (40 mg q2w) monotherapy for 24 weeks...
November 17, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27814772/-manganese-induced-neurotoxicity-a-review-of-its-behavioral-consequences-and-neuroprotective-strategies
#6
REVIEW
Tanara V Peres, Maria Rosa C Schettinger, Pan Chen, Fabiano Carvalho, Daiana S Avila, Aaron B Bowman, Michael Aschner
Manganese (Mn) is an essential heavy metal. However, Mn's nutritional aspects are paralleled by its role as a neurotoxicant upon excessive exposure. In this review, we covered recent advances in identifying mechanisms of Mn uptake and its molecular actions in the brain as well as promising neuroprotective strategies. The authors focused on reporting findings regarding Mn transport mechanisms, Mn effects on cholinergic system, behavioral alterations induced by Mn exposure and studies of neuroprotective strategies against Mn intoxication...
November 4, 2016: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/27812593/a-new-synthesis-and-preliminary-evaluation-of-some-analogues-of-mecamylamine-a-compound-with-anti-addiction-properties
#7
David Mangan, Neasa McNabola, Emily H Clark, Isabel Bermudez, Susan Wonnacott, J Mike Southern
A new synthesis of mecamylamine - a known anti-hypertensive drug with anti-addictive properties is described. The new route allowed access to two novel analogues whose activity at two nicotinic acetylcholine receptor subtypes was assessed.
November 4, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27810709/novel-approaches-to-the-automated-assay-of-%C3%AE-glucanase-and-lichenase-activity
#8
D Mangan, A Liadova, R Ivory, B V McCleary
We report herein the development of a novel assay procedure for the measurement of β-glucanase and lichenase (EC 3.2.1.73) in crude enzyme extracts. Two assay formats based on a) a direct cleavage or b) an enzyme coupled substrate were initially investigated. The 'direct cleavage' substrate, namely 4,6-O-benzylidene-2-chloro-4-nitrophenyl-β-3(1)-cellotriosyl-β-glucopyranoside (MBG4), was found to be the more generally applicable reagent. This substrate was fully characterised using a crude malt β-glucanase extract, a bacterial lichenase (Bacillus sp...
October 20, 2016: Carbohydrate Research
https://www.readbyqxmd.com/read/27800250/comparison-of-different-types-of-complications-in-the-phacoemulsification-surgery-learning-curve-according-to-number-of-operations-performed
#9
Mehmet Serhat Mangan, Eray Atalay, Ceyhun Arıcı, İbrahim Tuncer, Mustafa Değer Bilgeç
OBJECTIVES: To compare the differences in intraoperative complications rates by the number of resident-performed sequential phacoemulsification surgeries. MATERIALS AND METHODS: Preoperative and postoperative ophthalmological examination records and intraoperative data of 180 eyes of 140 patients who underwent cataract surgery by two residents between November 2009 and February 2012 were analyzed retrospectively. The data of 180 eyes were separated into 3 groups based on the number of operations performed: Group A (first 1-60 eyes), group B (61-120 eyes) and group C (last 121-180 eyes)...
January 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27746931/isotypic-mn-ii-and-fe-ii-binuclear-complexes-of-the-ligand-5-6-bis-pyridin-2-yl-pyrazine-2-3-di-carb-oxy-lic-acid
#10
Monserrat Alfonso, Helen Stoeckli-Evans
The title isotypic complexes, bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxylato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-manganese(II)] tetra-hydrate, [Mn2(C16H8N4O4)2(H2O)4]·4H2O, (I), and bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxyl-ato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-iron(II)] tetrahydrate, [Fe2(C16H8N4O4)2(H2O)4]·4H2O, (II), are, respectively, the mangan-ese(II) and iron(II) complexes of the ligand 5,6-bis-(pyridin-2-yl)-pyrazine-2,3-di-carb-oxy-lic acid...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/27690182/differences-in-treatment-goals-and-perception-of-symptom-burden-between-patients-with-myeloproliferative-neoplasms-mpns-and-hematologists-oncologists-in-the-united-states-findings-from-the-mpn-landmark-survey
#11
Ruben A Mesa, Carole B Miller, Maureen Thyne, James Mangan, Sara Goldberger, Salman Fazal, Xiaomei Ma, Wendy Wilson, Dilan C Paranagama, David G Dubinski, Ahmad Naim, Shreekant Parasuraman, John Boyle, John O Mascarenhas
BACKGROUND: This analysis of the myeloproliferative neoplasm (MPN) Landmark survey evaluated gaps between patient perceptions of their disease management and physician self-reported practices. METHODS: The survey included 813 patient respondents who had MPNs (myelofibrosis [MF], polycythemia vera [PV], or essential thrombocythemia [ET]) and 457 hematologist/oncologist respondents who treated patients with these conditions. RESULTS: Greater proportions of physician respondents reported using prognostic risk classifications (MF, 83%; PV, 59%; ET, 77%) compared with patient recollections (MF, 54%; PV, 17%; ET, 31%)...
September 30, 2016: Cancer
https://www.readbyqxmd.com/read/27687744/development-of-a-predictive-model-for-urgency-urinary-incontinence
#12
Amanda Darekar, Martin Carlsson, Sheila Quinn, Fady Ntanios, Erin Mangan, Daniel Arumi, David Scholfield
The ability to set realistic expectations of treatment response in patients with overactive bladder (OAB) can have an impact on patient engagement and adherence to study medication. In order to help set treatment expectations for OAB, a Physician Predictive Tool has been developed based on predictive modelling. Models have been developed utilizing data from eight Phase 3 and 4 fesoterodine clinical trials and these models enable the prediction of individual treatment response in subjects with OAB, based on various baseline characteristics...
September 27, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27665767/sodium-para-aminosalicylate-protected-cultured-basal-ganglia-astrocytes-from-manganese-induced-dna-damages-and-alteration-of-amino-acid-neurotransmitter-levels
#13
Shao-Jun Li, Yi-Ni Luo, Yong Li, Jing-Wen Chen, Yu-Huan Mo, Zong-Xiang Yuan, Shi-Yan Ou, Chao-Yan Ou, Yue-Ming Jiang, Xiang-Fa Deng
Sodium para-aminosalicylate (PAS-Na) was first applied successfully in clinical treatment of two manganism patients with good prognosis. However, the mechanism of how PAS-Na protects against Mn-induced neurotoxicity is still elusive. The current study was conducted to explore the effects of PAS-Na on Mn-induced basal ganglia astrocyte injury, and the involvement of amino acid neurotransmitter in vitro. Basal ganglia astrocytes were exposed to 500 μM manganese chloride (MnCl2) for 24 hr, following by 50, 150, or 450 μM PAS-Na treatment for another 24 hr...
2016: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/27648231/two-in-one-cryptic-species-discovered-in-biological-control-agent-populations-using-molecular-data-and-crossbreeding-experiments
#14
Iain D Paterson, Rosie Mangan, Douglas A Downie, Julie A Coetzee, Martin P Hill, Ashley M Burke, Paul O Downey, Thomas J Henry, Stephe G Compton
There are many examples of cryptic species that have been identified through DNA-barcoding or other genetic techniques. There are, however, very few confirmations of cryptic species being reproductively isolated. This study presents one of the few cases of cryptic species that has been confirmed to be reproductively isolated and therefore true species according to the biological species concept. The cryptic species are of special interest because they were discovered within biological control agent populations...
September 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27635361/cross-sectional-study-of-expression-of-divalent-metal-transporter-1-transferrin-and-hepcidin-in-blood-of-smelters-who-are-occupationally-exposed-to-manganese
#15
Qiyuan Fan, Yan Zhou, Changyin Yu, Jian Chen, Xiujuan Shi, Yanshu Zhang, Wei Zheng
BACKGROUND: Manganese (Mn) is widely used in industries including the manufacture of Mn-iron (Fe) alloy. Occupational Mn overexposure causes manganism. Mn is known to affect Fe metabolism; this study was designed to test the hypothesis that workers exposed to Mn may have an altered expression of mRNAs encoding proteins in Fe metabolism. METHODS: Workers occupationally exposed to Mn (n = 71) from a Mn-Fe alloy factory and control workers without Mn-exposure (n = 48) from a pig-iron plant from Zunyi, China, were recruited for this study...
2016: PeerJ
https://www.readbyqxmd.com/read/27580318/-limb-salvage-with-intrepid-dynamic-exoskeleton-orthosis-versus-transtibial-amputation-a-comparison-of-functional-gait-outcomes
#16
Katharine I Mangan, Trevor D Kingsbury, Brittney N Mazzone, Marilynn P Wyatt, Kevin M Kuhn
OBJECTIVES: To determine if there is a difference in functional gait outcomes between patients with limb injuries treated with either transtibial amputation or limb preservation with Intrepid Dynamic Exoskeletal Orthosis (IDEO). DESIGN: Retrospective prognostic study. SETTING: Tertiary referral military hospital. PATIENTS: This study included 10 transtibial amputees and ten limb preservation patients using the IDEO who were matched by body mass index after excluding for non-traumatic, proximal ipsilateral, contralateral, spine or traumatic brain injuries...
August 23, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27562457/yolk-shell-mno-znmn2-o4-n-c-nanorods-derived-from-%C3%AE-mno2-zif-8-as-anode-materials-for-lithium-ion-batteries
#17
Ming Zhong, Donghui Yang, Chenchao Xie, Zhang Zhang, Zhen Zhou, Xian-He Bu
Manganese oxides (MnOx ) are promising anode materials for lithium ion batteries, but they generally exhibit mediocre performances due to intrinsic low ionic conductivity, high polarization, and poor stability. Herein, yolk-shell nanorods comprising of nitrogen-doped carbon (N-C) coating on manganese monoxide (MnO) coupled with zinc manganate (ZnMn2 O4 ) nanoparticles are manufactured via one-step carbonization of α-MnO2 /ZIF-8 precursors. When evaluated as anodes for lithium ion batteries, MnO@ZnMn2 O4 /N-C exhibits an reversible capacity of 803 mAh g(-1) at 50 mA g(-1) after 100 cycles, excellent cyclability with a capacity of 595 mAh g(-1) at 1000 mAg(-1) after 200 cycles, as well as better rate capability compared with those non-N-C shelled manganese oxides (MnOx )...
August 26, 2016: Small
https://www.readbyqxmd.com/read/27557271/high-energy-1572-3-nm-pulses-for-co-sub-2-sub-lidar-from-a-polarization-maintaining-very-large-mode-area-er-doped-fiber-amplifier
#18
J W Nicholson, A DeSantolo, M F Yan, P Wisk, B Mangan, G Puc, A W Yu, M A Stephen
We demonstrate the first polarization-maintaining, very-large-mode-area, Er-doped fiber amplifier with ~1100 μm<sup>2</sup> effective area. The amplifier is core pumped by a Raman fiber laser and is used to generate single-frequency, one-microsecond, pulses with pulse energy of 541 μJ, peak power of 700 W, M<sup>2</sup> of 1.1, and polarization extinction > 20 dB. The amplifier operates at 1572.3 nm, a wavelength useful for trace atmospheric CO<sub>2</sub> detection.
August 22, 2016: Optics Express
https://www.readbyqxmd.com/read/27551079/ph-determines-the-energetic-efficiency-of-the-cyanobacterial-co2-concentrating-mechanism
#19
Niall M Mangan, Avi Flamholz, Rachel D Hood, Ron Milo, David F Savage
Many carbon-fixing bacteria rely on a CO2 concentrating mechanism (CCM) to elevate the CO2 concentration around the carboxylating enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO). The CCM is postulated to simultaneously enhance the rate of carboxylation and minimize oxygenation, a competitive reaction with O2 also catalyzed by RuBisCO. To achieve this effect, the CCM combines two features: active transport of inorganic carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous microcompartments called carboxysomes...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27521339/efficacy-and-pharmacology-of-the-nlrp3-inflammasome-inhibitor-cp-456-773-crid3-in-murine-models-of-dermal-and-pulmonary-inflammation
#20
Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Paul D Bonin, Matthew Mangan, Ken Dower, Brian G Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth, J Perry Hall
A critical component of innate immune response to infection and tissue damage is the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome, and this pathway and its activation products have been implicated in the pathophysiology of a variety of diseases. NLRP3 inflammasome activation leads to the cleavage of pro-IL-1β and pro-IL-18, as well as the subsequent release of biologically active IL-1β, IL-18, and other soluble mediators of inflammation. In this study, we further define the pharmacology of the previously reported NLRP3 inflammasome-selective, IL-1β processing inhibitor CP-456,773 (also known as MCC950), and we demonstrate its efficacy in two in vivo models of inflammation...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
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