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https://www.readbyqxmd.com/read/28722417/improving-carrier-lifetime-of-tin-sulfide-via-prediction-and-mitigation-of-harmful-point-defects
#1
Alex Polizzotti, Alireza Faghaninia, Jeremy R Poindexter, Lea Nienhaus, Vera Steinmann, Robert L Z Hoye, Alexandre Felten, Amjad Deyine, Niall Mangan, Juan-Pablo Correa-Baena, Seong Sik Shin, Shaffiq Jaffer, Moungi G Bawendi, Cynthia Lo, Tonio Buonassisi
Tin monosulfide (SnS) is an emerging thin-film absorber material for photovoltaics. An outstanding challenge is to improve carrier lifetimes to >1 ns, which should enable >10% device efficiencies. However, reported results to date have only demonstrated lifetimes at or below 100 ps. In this study, we employ defect modeling to identify the sulfur vacancy and defects from Fe, Co, and Mo as most recombination-active. We attempt to minimize these defects in crystalline samples through high-purity, sulfur-rich growth and experimentally improve lifetimes to >3 ns - thus achieving our 1 ns goal...
July 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28722018/a-pro-survival-role-for-the-intracellular-granzyme-b-inhibitor-serpinb9-in-natural-killer-cells-during-poxvirus-infection
#2
Matthew S Mangan, Carolina R Melo-Silva, Jennii Luu, Catherina H Bird, Aulikki Koskinen, Alexandra Rizzitelli, Monica Prakash, Katrina L Scarff, Arno Müllbacher, Matthias Regner, Phillip I Bird
Intracellular serpins are proposed to inactivate proteases released from lysosome-related organelles into the host cell interior, preventing cell death. Serpinb9 opposes the immune cytotoxic protease, granzyme B, and in a number of settings protects cells against granzyme B-mediated cell death. Using a knockout mouse line engineered to express green fluorescent protein under the serpbinb9 promoter, we demonstrate that serpinb9 is vital for host survival during Ectromelia virus infection by maintaining both mature NK cells, and activated CD8(+) T cells...
July 19, 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28721788/integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-miller-robin-brown-hilary-and-mangan-catherine-integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-232pp-%C3%A2-22-99-jessica-kingsley-9781849056465
#3
(no author information available yet)
The blurb of this book suggests it is about leading, managing and delivering integrated care, but it could be applied to any kind of change in healthcare services.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28692648/zebrafish-slc30a10-deficiency-revealed-a-novel-compensatory-mechanism-of-atp2c1-in-maintaining-manganese-homeostasis
#4
Zhidan Xia, Jiayu Wei, Yingniang Li, Jia Wang, Wenwen Li, Kai Wang, Xiaoli Hong, Lu Zhao, Caiyong Chen, Junxia Min, Fudi Wang
Recent studies found that mutations in the human SLC30A10 gene, which encodes a manganese (Mn) efflux transporter, are associated with hypermanganesemia with dystonia, polycythemia, and cirrhosis (HMDPC). However, the relationship between Mn metabolism and HMDPC is poorly understood, and no specific treatments are available for this disorder. Here, we generated two zebrafish slc30a10 mutant lines using the CRISPR/Cas9 system. Compared to wild-type animals, mutant adult animals developed significantly higher systemic Mn levels, and Mn accumulated in the brain and liver of mutant embryos in response to exogenous Mn...
July 10, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28663501/plant-diversity-increases-with-the-strength-of-negative-density-dependence-at-the-global-scale
#5
Joseph A LaManna, Scott A Mangan, Alfonso Alonso, Norman A Bourg, Warren Y Brockelman, Sarayudh Bunyavejchewin, Li-Wan Chang, Jyh-Min Chiang, George B Chuyong, Keith Clay, Richard Condit, Susan Cordell, Stuart J Davies, Tucker J Furniss, Christian P Giardina, I A U Nimal Gunatilleke, C V Savitri Gunatilleke, Fangliang He, Robert W Howe, Stephen P Hubbell, Chang-Fu Hsieh, Faith M Inman-Narahari, David Janík, Daniel J Johnson, David Kenfack, Lisa Korte, Kamil Král, Andrew J Larson, James A Lutz, Sean M McMahon, William J McShea, Hervé R Memiaghe, Anuttara Nathalang, Vojtech Novotny, Perry S Ong, David A Orwig, Rebecca Ostertag, Geoffrey G Parker, Richard P Phillips, Lawren Sack, I-Fang Sun, J Sebastián Tello, Duncan W Thomas, Benjamin L Turner, Dilys M Vela Díaz, Tomáš Vrška, George D Weiblen, Amy Wolf, Sandra Yap, Jonathan A Myers
Theory predicts that higher biodiversity in the tropics is maintained by specialized interactions among plants and their natural enemies that result in conspecific negative density dependence (CNDD). By using more than 3000 species and nearly 2.4 million trees across 24 forest plots worldwide, we show that global patterns in tree species diversity reflect not only stronger CNDD at tropical versus temperate latitudes but also a latitudinal shift in the relationship between CNDD and species abundance. CNDD was stronger for rare species at tropical versus temperate latitudes, potentially causing the persistence of greater numbers of rare species in the tropics...
June 30, 2017: Science
https://www.readbyqxmd.com/read/28651968/sodium-p-aminosalicylic-acid-inhibits-sub-chronic-manganese-induced-neuroinflammation-in-rats-by-modulating-mapk-and-cox-2
#6
Shao-Jun Li, Wen-Xia Qin, Dong-Jie Peng, Zong-Xiang Yuan, Sheng-Nan He, Yi-Ni Luo, Michael Aschner, Yue-Ming Jiang, Dian-Yin Liang, Bing-Yan Xie, Fang Xu
Excessive manganese (Mn) accumulation in the brain may induce an extrapyramidal disorder known as manganism. Inflammatory processes play a critical role in neurodegenerative diseases. Therapeutically, non-steroidal anti-inflammatory drugs or analogous anti-inflammatory therapies have neuroprotective effects. As a non-steroidal anti-inflammatory drug, p-aminosalicylic acid (PAS) has anti-inflammatory effects, which are mediated by decreased prostaglandins E2 (PGE2) levels. The aim of the current study was to investigate whether PAS-Na treatment prevents Mn-induced behavioral changes and neuroinflammation in vivo...
June 23, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28610743/valproate-and-sodium-butyrate-attenuate-manganese-decreased-locomotor-activity-and-astrocytic-glutamate-transporters-expression-in-mice
#7
James Johnson, Edward Alain B Pajarillo, Equar Taka, Romonia Reams, Deok-Soo Son, Michael Aschner, Eunsook Lee
Manganese (Mn) is an essential trace element, but chronic overexposure to this metal, either environmentally or occupationally may cause manganism, a disease analogous to Parkinson's disease. Inhibitors of histone deacetylases, such as valproic acid (VPA) and sodium butyrate (NaB) exert neuroprotective effects in various animal models of neurological disorders. Thus, the present study investigated whether VPA or NaB prevent Mn-induced neurotoxicity by assessing locomotor activities and expression of astrocytic glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST), in C57BL/6 mice...
June 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28605110/methylenecyclopropane-annulation-by-manganese-i-catalyzed-stereoselective-c-h-c-c-activation
#8
Yu-Feng Liang, Valentin Müller, Weiping Liu, Annika Münch, Dietmar Stalke, Lutz Ackermann
C-H/C-C functionalizations with challenging methylenecyclopropanes (MCPs) were accomplished with a versatile base metal catalyst. Thus, a robust manganese(I) complex enabled the expedient annulation of MCPs by synthetically meaningful ketimines to deliver - upon one-pot hydroarylation - densely substituted polycylic anilines in a step-economical fashion. Mechanistic studies provided strong support for a facile organometallic C-H manganation, while typical cobalt, ruthenium, rhodium and palladium catalyst were found completely ineffective...
June 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28602308/magnetic-ionic-liquids-as-extraction-solvents-in-vacuum-headspace-single-drop-microextraction
#9
María J Trujillo-Rodríguez, Verónica Pino, Jared L Anderson
A vacuum headspace single-drop microextraction method based on the use of magnetic ionic liquids (vacuum MIL-HS-SDME) for the determination of short chain free fatty acids is described for the first time. The basis of the method involves the use of a rod magnet to aid in maintaining a small microdroplet of magnetic ionic liquid (MIL) during headspace single-drop microextraction (HS-SDME). The application favors reduced pressure conditions inside the sampling vial while maintaining the MIL droplet in the headspace...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28579395/cryopreservation-maintains-functionality-of-human-ipsc-dopamine-neurons-and-rescues-parkinsonian-phenotypes-in%C3%A2-vivo
#10
Dustin R Wakeman, Benjamin M Hiller, David J Marmion, Christopher W McMahon, Grant T Corbett, Kile P Mangan, Junyi Ma, Lauren E Little, Zhong Xie, Tamara Perez-Rosello, Jaime N Guzman, D James Surmeier, Jeffrey H Kordower
A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle, midbrain dopamine neurons were derived from human induced pluripotent stem cells (iPSC-mDA) and cryopreserved in large production lots for biochemical and transplantation studies. Cryopreserved, post-mitotic iPSC-mDA neurons retained high viability with gene, protein, and electrophysiological signatures consistent with midbrain floor-plate lineage...
July 11, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28577504/isolation-and-characterization-of-cepa2-a-natural-alliospiroside-a-from-shallot-allium-cepa-l-aggregatum-group-with-anticancer-activity
#11
Mostafa Abdelrahman, Hassan Y A H Mahmoud, Magdi El-Sayed, Shuhei Tanaka, Lam-Son Phan Tran
Exploration of new and promising anticancer compounds continues to be one of the main tasks of cancer research because of the drug resistance, high cytotoxicity and limitations of tumor selectivity. Natural products represent a better choice for cancer treatment in comparison with synthetic compounds because of their pharmacokinetic properties and lower side effects. In the current study, we isolated a steroidal saponin, named Cepa2, from the dry roots of shallot (Allium cepa L. Aggregatum group), and determined its structure by using two-dimensional nuclear manganic resonance (2D NMR)...
May 19, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28576570/deinococcus-mn-2-peptide-complex-a-novel-approach-to-alphavirus-vaccine-development
#12
Manoshi Gayen, Paridhi Gupta, Elaine M Morazzani, Elena K Gaidamakova, Barbara Knollmann-Ritschel, Michael J Daly, Pamela J Glass, Radha K Maheshwari
Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been developed as a bioweapon in the past due to its ease of preparation, aerosol dispersion and high lethality in aerosolized form. Currently, there are no FDA approved vaccines against these viruses...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28560925/integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-miller-robin-brown-hilary-and-mangan-catherine-integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-232pp-%C3%A2-22-99-jessica-kingsley-9781849056465
#13
(no author information available yet)
The blurb of this book suggests it is about leading, managing and delivering integrated care, but it could be applied to any kind of change in healthcare services.
May 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28556511/host-specific-effects-of-soil-microbial-filtrates-prevail-over-those-of-arbuscular-mycorrhizae-in-a-fragmented-landscape
#14
Camila Pizano, Scott A Mangan, James H Graham, Kaoru Kitajima
Plant-soil interactions have been shown to determine plant community composition in a wide range of environments. However, how plants distinctly interact with beneficial and detrimental organisms across mosaic landscapes containing fragmented habitats is still poorly understood. We experimentally tested feedback responses between plants and soil microbial communities from adjacent habitats across a disturbance gradient within a human-modified tropical montane landscape. In a greenhouse experiment, two components of soil microbial communities were amplified; arbuscular mycorrhizal fungi (AMF) and a filtrate excluding AMF spores from the soils of pastures (high disturbance), coffee plantations (intermediate disturbance), and forest fragments (low disturbance), using potted seedlings of 11 plant species common in these habitats (pasture grass, coffee, and 9 native species)...
May 28, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28556405/tuberculosis-in-china-a-longitudinal-predictive-model-of-the-general-population-and-recommendations-for-achieving-who-goals
#15
Kaijin Xu, Cheng Ding, Connor J Mangan, Yiping Li, Jingjing Ren, Shigui Yang, Bing Wang, Bing Ruan, Jifang Sheng, Lanjuan Li
BACKGROUND AND OBJECTIVE: Tuberculosis (TB) remains a major public health challenge. China accounts for more than 10% of the global TB burden, and effective modelling of TB trends remains limited. METHODS: We used data drawn primarily from two Chinese nation-wide cross-sectional epidemiological surveys combined with data from China's National Disease Reporting Network to construct an eight-state Markov model that simulates TB prevalence. By adjusting the relevant parameters, we evaluated which characteristics have the greatest bearing upon prevalence and efficacy of the response measures...
May 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28544937/recycling-metals-from-lithium-ion-battery-by-mechanical-separation-and-vacuum-metallurgy
#16
Jiefeng Xiao, Jia Li, Zhengming Xu
The large-batch application of lithium ion batteries leads to the mass production of spent batteries. So the enhancement of disposal ability of spent lithium ion batteries is becoming very urgent. This study proposes an integrated process to handle bulk spent lithium manganese (LiMn2O4) batteries to in situ recycle high value-added products without any additives. By mechanical separation, the mixed electrode materials mainly including binder, graphite and LiMn2O4 are firstly obtained from spent batteries. Then, the reaction characteristics for the oxygen-free roasting of mixed electrode materials are analyzed...
May 17, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28511934/repeated-manganese-administration-produced-abnormal-expression-of-circadian-clock-genes-in-the-hypothalamus-and-liver-of-rats
#17
Huan Li, Ximin Fan, Ying Luo, Sheng Song, Jie Liu, Qiyuan Fan
Manganese (Mn) neurotoxicity displays non-motor dysfunction and motor impairment like Parkinson's disease (PD), and is called as Manganism. Circadian disruption is a non-motor symptom found in PD and Manganism. Clock genes are essential to drive and maintain circadian rhythm, but little is known about Mn exposure on circadian clock genes expression. Both the brain and liver are targets of Mn, we hypothesize that repeated Mn administration could affect clock gene expression in the hypothalamus and livers. Male Sprague-Dawley rats were intraperitoneally injected Mn(2+) 1mg and 5mg/kg as MnCl2·4H2O, every other day for 30 days...
May 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28500793/integrating-the-genomic-architecture-of-human-nucleolar-organizer-regions-with-the-biophysical-properties-of-nucleoli
#18
REVIEW
Hazel Mangan, Michael Ó Gailín, Brian McStay
Nucleoli are the sites of ribosome biogenesis and the largest membraneless sub-nuclear structures. They are intimately linked with growth and proliferation control and function as sensors of cellular stress. Nucleoli form around arrays of ribosomal gene (rDNA) repeats also called nucleolar organizer regions (NORs). In humans, NORs are located on the short arms of all five human acrocentric chromosomes. Multiple NORs contribute to the formation of large heterochromatin-surrounded nucleoli observed in most human cells...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28484760/comparison-of-nucleophilic-and-radical-based-routes-to-the-formation-of-manganese-main-group-element-single-bonds
#19
Douglas W Agnew, Curtis E Moore, Arnold L Rheingold, Joshua S Figueroa
Using the stable metalloradical Mn(CO)3(CNAr(Dipp2))2, we report the formation of manganese-main group complexes via the single-electron functionalization of main group halides. The reactions occur in a simple 1 : 1 stoichiometry, and demonstrate the utility of using stable open-shelled organometallics as precursors for metal-main group compounds. This has enabled the preparation of manganese complexes bearing terminal -EXn substituents, as shown through the isolation of Mn(SnCl)(CO)3(CNAr(Dipp2))2 and Mn(BiCl2)(CO)3(CNAr(Dipp2))2 from SnCl2 and BiCl3, respectively...
May 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28479240/fesoterodine-for-the-treatment-of-nocturnal-urgency-in-patients-with-overactive-bladder-syndrome-an-analysis-of-responders-and-non-responders
#20
Johnathan A Khusid, Jeffrey P Weiss, Martin O Carlsson, Erin K Mangan
PURPOSE: A recent study demonstrated improvement of nocturnal urgency in patients with overactive bladder (OAB) when treated with fesoterodine. The current study aims to determine which bladder diary parameters predict response to fesoterodine in these patients. MATERIALS AND METHODS: Patients with nocturnal urgency completed a 2-week, single-blind, placebo run-in, followed by 1:1 double-blind randomization to 12 weeks of fesoterodine or placebo. We analysed changes from baseline to week 12 of bladder diary parameters including actual number night voids (ANV, total # nocturia episodes), maximum voided volume (MVV), nocturnal bladder capacity (NBC), nocturnal bladder capacity index (NBCi = ANV- NUV/MVV-1), nocturnal urine volume (NUV), nocturia index (Ni = NUV/MVV), nocturnal polyuria index and (NPi = NUV/24 hour volume)...
May 4, 2017: Journal of Urology
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