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Monserrat Alfonso, Helen Stoeckli-Evans
The title isotypic complexes, bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxylato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-manganese(II)] tetra-hydrate, [Mn2(C16H8N4O4)2(H2O)4]·4H2O, (I), and bis-[μ-5,6-bis-(pyridin-2-yl)pyrazine-2,3-di-carboxyl-ato]-κ(4)N(1),O(2),N(6):O(3);κ(4)O(3):N(1),O(2),N(6)-bis-[di-aqua-iron(II)] tetrahydrate, [Fe2(C16H8N4O4)2(H2O)4]·4H2O, (II), are, respectively, the mangan-ese(II) and iron(II) complexes of the ligand 5,6-bis-(pyridin-2-yl)-pyrazine-2,3-di-carb-oxy-lic acid...
October 1, 2016: Acta Crystallographica. Section E, Crystallographic Communications
Ruben A Mesa, Carole B Miller, Maureen Thyne, James Mangan, Sara Goldberger, Salman Fazal, Xiaomei Ma, Wendy Wilson, Dilan C Paranagama, David G Dubinski, Ahmad Naim, Shreekant Parasuraman, John Boyle, John O Mascarenhas
BACKGROUND: This analysis of the myeloproliferative neoplasm (MPN) Landmark survey evaluated gaps between patient perceptions of their disease management and physician self-reported practices. METHODS: The survey included 813 patient respondents who had MPNs (myelofibrosis [MF], polycythemia vera [PV], or essential thrombocythemia [ET]) and 457 hematologist/oncologist respondents who treated patients with these conditions. RESULTS: Greater proportions of physician respondents reported using prognostic risk classifications (MF, 83%; PV, 59%; ET, 77%) compared with patient recollections (MF, 54%; PV, 17%; ET, 31%)...
September 30, 2016: Cancer
Amanda Darekar, Martin Carlsson, Sheila Quinn, Fady Ntanios, Erin Mangan, Daniel Arumi, David Scholfield
The ability to set realistic expectations of treatment response in patients with overactive bladder (OAB) can have an impact on patient engagement and adherence to study medication. In order to help set treatment expectations for OAB, a Physician Predictive Tool has been developed based on predictive modelling. Models have been developed utilizing data from eight Phase 3 and 4 fesoterodine clinical trials and these models enable the prediction of individual treatment response in subjects with OAB, based on various baseline characteristics...
September 27, 2016: Contemporary Clinical Trials
Shao-Jun Li, Yi-Ni Luo, Yong Li, Jing-Wen Chen, Yu-Huan Mo, Zong-Xiang Yuan, Shi-Yan Ou, Chao-Yan Ou, Yue-Ming Jiang, Xiang-Fa Deng
Sodium para-aminosalicylate (PAS-Na) was first applied successfully in clinical treatment of two manganism patients with good prognosis. However, the mechanism of how PAS-Na protects against Mn-induced neurotoxicity is still elusive. The current study was conducted to explore the effects of PAS-Na on Mn-induced basal ganglia astrocyte injury, and the involvement of amino acid neurotransmitter in vitro. Basal ganglia astrocytes were exposed to 500 μM manganese chloride (MnCl2) for 24 hr, following by 50, 150, or 450 μM PAS-Na treatment for another 24 hr...
2016: Journal of Toxicological Sciences
Iain D Paterson, Rosie Mangan, Douglas A Downie, Julie A Coetzee, Martin P Hill, Ashley M Burke, Paul O Downey, Thomas J Henry, Stephe G Compton
There are many examples of cryptic species that have been identified through DNA-barcoding or other genetic techniques. There are, however, very few confirmations of cryptic species being reproductively isolated. This study presents one of the few cases of cryptic species that has been confirmed to be reproductively isolated and therefore true species according to the biological species concept. The cryptic species are of special interest because they were discovered within biological control agent populations...
September 2016: Ecology and Evolution
Qiyuan Fan, Yan Zhou, Changyin Yu, Jian Chen, Xiujuan Shi, Yanshu Zhang, Wei Zheng
BACKGROUND: Manganese (Mn) is widely used in industries including the manufacture of Mn-iron (Fe) alloy. Occupational Mn overexposure causes manganism. Mn is known to affect Fe metabolism; this study was designed to test the hypothesis that workers exposed to Mn may have an altered expression of mRNAs encoding proteins in Fe metabolism. METHODS: Workers occupationally exposed to Mn (n = 71) from a Mn-Fe alloy factory and control workers without Mn-exposure (n = 48) from a pig-iron plant from Zunyi, China, were recruited for this study...
2016: PeerJ
Katharine I Mangan, Trevor D Kingsbury, Brittney N Mazzone, Marilynn P Wyatt, Kevin M Kuhn
OBJECTIVES: To determine if there is a difference in functional gait outcomes between patients with limb injuries treated with either transtibial amputation or limb preservation with Intrepid Dynamic Exoskeletal Orthosis (IDEO). DESIGN: Retrospective prognostic study. SETTING: Tertiary referral military hospital. PATIENTS: This study included 10 transtibial amputees and ten limb preservation patients using the IDEO who were matched by body mass index after excluding for non-traumatic, proximal ipsilateral, contralateral, spine or traumatic brain injuries...
August 23, 2016: Journal of Orthopaedic Trauma
Ming Zhong, Donghui Yang, Chenchao Xie, Zhang Zhang, Zhen Zhou, Xian-He Bu
Manganese oxides (MnOx ) are promising anode materials for lithium ion batteries, but they generally exhibit mediocre performances due to intrinsic low ionic conductivity, high polarization, and poor stability. Herein, yolk-shell nanorods comprising of nitrogen-doped carbon (N-C) coating on manganese monoxide (MnO) coupled with zinc manganate (ZnMn2 O4 ) nanoparticles are manufactured via one-step carbonization of α-MnO2 /ZIF-8 precursors. When evaluated as anodes for lithium ion batteries, MnO@ZnMn2 O4 /N-C exhibits an reversible capacity of 803 mAh g(-1) at 50 mA g(-1) after 100 cycles, excellent cyclability with a capacity of 595 mAh g(-1) at 1000 mAg(-1) after 200 cycles, as well as better rate capability compared with those non-N-C shelled manganese oxides (MnOx )...
August 26, 2016: Small
J W Nicholson, A DeSantolo, M F Yan, P Wisk, B Mangan, G Puc, A W Yu, M A Stephen
We demonstrate the first polarization-maintaining, very-large-mode-area, Er-doped fiber amplifier with ~1100 μm<sup>2</sup> effective area. The amplifier is core pumped by a Raman fiber laser and is used to generate single-frequency, one-microsecond, pulses with pulse energy of 541 μJ, peak power of 700 W, M<sup>2</sup> of 1.1, and polarization extinction > 20 dB. The amplifier operates at 1572.3 nm, a wavelength useful for trace atmospheric CO<sub>2</sub> detection.
August 22, 2016: Optics Express
Niall M Mangan, Avi Flamholz, Rachel D Hood, Ron Milo, David F Savage
Many carbon-fixing bacteria rely on a CO2 concentrating mechanism (CCM) to elevate the CO2 concentration around the carboxylating enzyme ribulose bisphosphate carboxylase/oxygenase (RuBisCO). The CCM is postulated to simultaneously enhance the rate of carboxylation and minimize oxygenation, a competitive reaction with O2 also catalyzed by RuBisCO. To achieve this effect, the CCM combines two features: active transport of inorganic carbon into the cell and colocalization of carbonic anhydrase and RuBisCO inside proteinaceous microcompartments called carboxysomes...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
Michael J Primiano, Bruce A Lefker, Michael R Bowman, Andrea G Bree, Cedric Hubeau, Paul D Bonin, Matthew Mangan, Ken Dower, Brian G Monks, Leah Cushing, Stephen Wang, Julia Guzova, Aiping Jiao, Lih-Ling Lin, Eicke Latz, David Hepworth, J Perry Hall
A critical component of innate immune response to infection and tissue damage is the NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome, and this pathway and its activation products have been implicated in the pathophysiology of a variety of diseases. NLRP3 inflammasome activation leads to the cleavage of pro-IL-1β and pro-IL-18, as well as the subsequent release of biologically active IL-1β, IL-18, and other soluble mediators of inflammation. In this study, we further define the pharmacology of the previously reported NLRP3 inflammasome-selective, IL-1β processing inhibitor CP-456,773 (also known as MCC950), and we demonstrate its efficacy in two in vivo models of inflammation...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
J M Mangan, T E Tupasi, A M C G Garfin, V Lofranco, R Orillaza-Chi, R Basilio, L C Naval, G I Balane, E S Joson, D Burt, W-J Lew, M Mantala, S Pancho, J N Sarol, A Golubkov, E V Kurbatova
SETTING: Multidrug-resistant tuberculosis (MDR-TB) patients lost to follow-up (LTFU) from Programmatic Management of Drug-resistant Tuberculosis facilities in the Philippines. OBJECTIVES: To gain insight into patients' readiness to return to treatment. METHODS: MDR-TB patients who initiated treatment and were categorized as LTFU were identified using TB registers, contacted, and asked to consent to an interview and medical record review. At the conclusion of the interview, patients' readiness to restart treatment was assessed and examined in relation to demographic, clinical, and interview data...
September 2016: International Journal of Tuberculosis and Lung Disease
Tomasz Próchnicki, Matthew S Mangan, Eicke Latz
Inflammasomes are high-molecular-weight protein complexes that are formed in the cytosolic compartment in response to danger- or pathogen-associated molecular patterns. These complexes enable activation of an inflammatory protease caspase-1, leading to a cell death process called pyroptosis and to proteolytic cleavage and release of pro-inflammatory cytokines interleukin (IL)-1β and IL-18. Along with caspase-1, inflammasome components include an adaptor protein, ASC, and a sensor protein, which triggers the inflammasome assembly in response to a danger signal...
2016: F1000Research
Anthony J Mangan, Daniel V Sietsema, Dongying Li, Jeffrey K Moore, Sandra Citi, Rytis Prekeris
Coordinated polarization of epithelial cells is a key step during morphogenesis that leads to the formation of an apical lumen. Rab11 and its interacting protein FIP5 are necessary for the targeting of apical endosomes to the midbody and apical membrane initiation site (AMIS) during lumenogenesis. However, the machinery that mediates AMIS establishment and FIP5-endosome targeting remains unknown. Here we identify a FIP5-interacting protein, Cingulin, which localizes to the AMIS and functions as a tether mediating FIP5-endosome targeting...
2016: Nature Communications
Shi-Kui Han, Chao Gu, Songtao Zhao, Sen Xu, Ming Gong, Zhenyu Li, Shu-Hong Yu
Heteronanostructures have attracted intensive attention due to their electronic coupling effects between distinct components. Despite tremendous advances of nanostructure fabrication, combining independent polymorphs by forming heterojunction is still challenging but fascinating, such as copper sulfides (Cu2-xS), exhibiting varying band gaps and crystal structures with various stoichiometries. Herein, self-coupled Cu2-xS polymorphs (Cu1.94S-CuS) by a facile one-pot chemical transformation route have been reported for the first time...
October 5, 2016: Journal of the American Chemical Society
Nannan Yang, Yang Wei, Tan Wang, Jifeng Guo, Qiying Sun, Yacen Hu, Xinxiang Yan, Xiongwei Zhu, Beisha Tang, Qian Xu
Exposure to excessive manganese (Mn) causes manganism, a progressive neurodegenerative disorder similar to idiopathic Parkinson's disease (IPD). The detailed mechanisms of Mn neurotoxicity in nerve cells, especially in dopaminergic neurons are not yet fully understood. Meanwhile, it is unknown whether there exists a potential antagonist or effective drug for treating neuron damage in manganism. In the present study, we report the discovery of an HIF prolyl-hydroxylase inhibitor, DMOG [N-(2-Methoxy-2-oxoacetyl) glycine methyl ester], that can partially inhibit manganese toxicity not only in the neuroblastoma cell line SH-SY5Y in vitro but also in a mouse model in vivo...
2016: Scientific Reports
Xiaohui Shen, Qi Wang, Yuhong Liu, Wenxiao Xue, Lie Ma, Shuaihui Feng, Mimi Wan, Fenghe Wang, Chun Mao
Quantitative analysis of superoxide anion (O2(·-)) has increasing importance considering its potential damages to organism. Herein, a novel Mn-superoxide dismutase (MnSOD) mimics, silica-manganous phosphate (SiO2-Mn3(PO4)2) nanoparticles, were designed and synthesized by surface self-assembly processes that occur on the surface of silica-phytic acid (SiO2-PA) nanoparticles. The composite nanoparticles were characterized by fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electronic microscopy (SEM), electron diffraction pattern, energy dispersive spectroscopy (EDS) and elemental mapping...
2016: Scientific Reports
A Frano, S Blanco-Canosa, E Schierle, Y Lu, M Wu, M Bluschke, M Minola, G Christiani, H U Habermeier, G Logvenov, Y Wang, P A van Aken, E Benckiser, E Weschke, M Le Tacon, B Keimer
The interplay between charge density waves (CDWs) and high-temperature superconductivity is currently under intense investigation. Experimental research on this issue is difficult because CDW formation in bulk copper oxides is strongly influenced by random disorder, and a long-range-ordered CDW state in high magnetic fields is difficult to access with spectroscopic and diffraction probes. Here we use resonant X-ray scattering in zero magnetic field to show that interfaces with the metallic ferromagnet La2/3Ca1/3MnO3 greatly enhance CDW formation in the optimally doped high-temperature superconductor YBa2Cu3O6+δ (δ ∼ 1), and that this effect persists over several tens of nanometres...
August 2016: Nature Materials
Safa Bouabid, Karim Fifel, Abdelhamid Benazzouz, Nouria Lakhdar-Ghazal
Manganese (Mn) intoxication is associated with neurological dysfunctions collectively known as Parkinsonism or Manganism. Like in Parkinson's disease, Manganism is associated with motor disturbances, together with non-motor symptoms including cognitive and neuropsychiatric deficits. Although sleep dysfunctions are commonly reported among workers exposed to Mn, their underlying pathophysiology remains unknown. In this study, we investigated the rest-activity rhythms in rats treated daily with MnCl2 (10mg/kg, i...
September 7, 2016: Neuroscience
Kunkai Su, Qi Wang, Luoyang Qi, Dasong Hua, Jingjing Tao, Connor J Mangan, Yijia Lou, Lanjuan Li
Autoimmune hepatitis is characterized, in part, by the pathways involving cysteinyl-leukotriene metabolites of arachidonic acid, the dynamics of which remain unclear. Here, we explored post-transcriptional regulation in the 5-lipoxygenase (5-LO) pathway of arachidonic acid in a Concanavalin A (Con A) induced mouse model. We found that Con A administration lead to 5-LO overexpression and cysteinyl-leukotriene release in early hepatic injury, which was attenuated by cyclosporin A pretreatment. Subsequent microarray and qRT-PCR analysis further showed that microRNA-674-5p (miR-674-5p) displayed a significant decrease in expression in Con A-damaged liver...
September 6, 2016: Toxicology Letters
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