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https://www.readbyqxmd.com/read/28610743/valproate-and-sodium-butyrate-attenuate-manganese-decreased-locomotor-activity-and-astrocytic-glutamate-transporters-expression-in-mice
#1
James Johnson, Edward Alain B Pajarillo, Equar Taka, Romonia Reams, Deok-Soo Son, Michael Aschner, Eunsook Lee
Manganese (Mn) is an essential trace element, but chronic overexposure to this metal, either environmentally or occupationally may cause manganism, a disease analogous to Parkinson's disease. Inhibitors of histone deacetylases, such as valproic acid (VPA) and sodium butyrate (NaB) exert neuroprotective effects in various animal models of neurological disorders. Thus, the present study investigated whether VPA or NaB prevent Mn-induced neurotoxicity by assessing locomotor activities and expression of astrocytic glutamate transporters, glutamate transporter 1 (GLT-1) and glutamate aspartate transporter (GLAST), in C57BL/6 mice...
June 10, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28605110/methylenecyclopropane-annulation-by-manganese-i-catalyzed-stereoselective-c-h-c-c-activation
#2
Yu-Feng Liang, Valentin Müller, Weiping Liu, Annika Münch, Dietmar Stalke, Lutz Ackermann
C-H/C-C functionalizations with challenging methylenecyclopropanes (MCPs) were accomplished with a versatile base metal catalyst. Thus, a robust manganese(I) complex enabled the expedient annulation of MCPs by synthetically meaningful ketimines to deliver - upon one-pot hydroarylation - densely substituted polycylic anilines in a step-economical fashion. Mechanistic studies provided strong support for a facile organometallic C-H manganation, while typical cobalt, ruthenium, rhodium and palladium catalyst were found completely ineffective...
June 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28602308/magnetic-ionic-liquids-as-extraction-solvents-in-vacuum-headspace-single-drop-microextraction
#3
María J Trujillo-Rodríguez, Verónica Pino, Jared L Anderson
A vacuum headspace single-drop microextraction method based on the use of magnetic ionic liquids (vacuum MIL-HS-SDME) for the determination of short chain free fatty acids is described for the first time. The basis of the method involves the use of a rod magnet to aid in maintaining a small microdroplet of magnetic ionic liquid (MIL) during headspace single-drop microextraction (HS-SDME). The application favors reduced pressure conditions inside the sampling vial while maintaining the MIL droplet in the headspace...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28579395/cryopreservation-maintains-functionality-of-human-ipsc-dopamine-neurons-and-rescues-parkinsonian-phenotypes-in%C3%A2-vivo
#4
Dustin R Wakeman, Benjamin M Hiller, David J Marmion, Christopher W McMahon, Grant T Corbett, Kile P Mangan, Junyi Ma, Lauren E Little, Zhong Xie, Tamara Perez-Rosello, Jaime N Guzman, D James Surmeier, Jeffrey H Kordower
A major challenge for clinical application of pluripotent stem cell therapy for Parkinson's disease (PD) is large-scale manufacturing and cryopreservation of neurons that can be efficiently prepared with minimal manipulation. To address this obstacle, midbrain dopamine neurons were derived from human induced pluripotent stem cells (iPSC-mDA) and cryopreserved in large production lots for biochemical and transplantation studies. Cryopreserved, post-mitotic iPSC-mDA neurons retained high viability with gene, protein, and electrophysiological signatures consistent with midbrain floor-plate lineage...
May 22, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28577504/isolation-and-characterization-of-cepa2-a-natural-alliospiroside-a-from-shallot-allium-cepa-l-aggregatum-group-with-anticancer-activity
#5
Mostafa Abdelrahman, Hassan Y A H Mahmoud, Magdi El-Sayed, Shuhei Tanaka, Lam-Son Phan Tran
Exploration of new and promising anticancer compounds continues to be one of the main tasks of cancer research because of the drug resistance, high cytotoxicity and limitations of tumor selectivity. Natural products represent a better choice for cancer treatment in comparison with synthetic compounds because of their pharmacokinetic properties and lower side effects. In the current study, we isolated a steroidal saponin, named Cepa2, from the dry roots of shallot (Allium cepa L. Aggregatum group), and determined its structure by using two-dimensional nuclear manganic resonance (2D NMR)...
May 19, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28576570/deinococcus-mn-2-peptide-complex-a-novel-approach-to-alphavirus-vaccine-development
#6
Manoshi Gayen, Paridhi Gupta, Elaine M Morazzani, Elena K Gaidamakova, Barbara Knollmann-Ritschel, Michael J Daly, Pamela J Glass, Radha K Maheshwari
Over the last ten years, Chikungunya virus (CHIKV), an Old World alphavirus has caused numerous outbreaks in Asian and European countries and the Americas, making it an emerging pathogen of great global health importance. Venezuelan equine encephalitis virus (VEEV), a New World alphavirus, on the other hand, has been developed as a bioweapon in the past due to its ease of preparation, aerosol dispersion and high lethality in aerosolized form. Currently, there are no FDA approved vaccines against these viruses...
June 22, 2017: Vaccine
https://www.readbyqxmd.com/read/28560925/integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-miller-robin-brown-hilary-and-mangan-catherine-integrated-care-in-action-a-practical-guide-for-health-social-care-and-housing-supports-232pp-%C3%A2-22-99-jessica-kingsley-9781849056465
#7
(no author information available yet)
The blurb of this book suggests it is about leading, managing and delivering integrated care, but it could be applied to any kind of change in healthcare services.
May 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28556511/host-specific-effects-of-soil-microbial-filtrates-prevail-over-those-of-arbuscular-mycorrhizae-in-a-fragmented-landscape
#8
Camila Pizano, Scott A Mangan, James H Graham, Kaoru Kitajima
Plant-soil interactions have been shown to determine plant community composition in a wide range of environments. However, how plants distinctly interact with beneficial and detrimental organisms across mosaic landscapes containing fragmented habitats is still poorly understood. We experimentally tested feedback responses between plants and soil microbial communities from adjacent habitats across a disturbance gradient within a human-modified tropical montane landscape. In a greenhouse experiment, two components of soil microbial communities were amplified; arbuscular mycorrhizal fungi (AMF) and a filtrate excluding AMF spores from the soils of pastures (high disturbance), coffee plantations (intermediate disturbance), and forest fragments (low disturbance), using potted seedlings of 11 plant species common in these habitats (pasture grass, coffee, and 9 native species)...
May 28, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28556405/tuberculosis-in-china-a-longitudinal-predictive-model-of-the-general-population-and-recommendations-for-achieving-who-goals
#9
Kaijin Xu, Cheng Ding, Connor J Mangan, Yiping Li, Jingjing Ren, Shigui Yang, Bing Wang, Bing Ruan, Jifang Sheng, Lanjuan Li
BACKGROUND AND OBJECTIVE: Tuberculosis (TB) remains a major public health challenge. China accounts for more than 10% of the global TB burden, and effective modelling of TB trends remains limited. METHODS: We used data drawn primarily from two Chinese nation-wide cross-sectional epidemiological surveys combined with data from China's National Disease Reporting Network to construct an eight-state Markov model that simulates TB prevalence. By adjusting the relevant parameters, we evaluated which characteristics have the greatest bearing upon prevalence and efficacy of the response measures...
May 28, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28544937/recycling-metals-from-lithium-ion-battery-by-mechanical-separation-and-vacuum-metallurgy
#10
Jiefeng Xiao, Jia Li, Zhengming Xu
The large-batch application of lithium ion batteries leads to the mass production of spent batteries. So the enhancement of disposal ability of spent lithium ion batteries is becoming very urgent. This study proposes an integrated process to handle bulk spent lithium manganese (LiMn2O4) batteries to in situ recycle high value-added products without any additives. By mechanical separation, the mixed electrode materials mainly including binder, graphite and LiMn2O4 are firstly obtained from spent batteries. Then, the reaction characteristics for the oxygen-free roasting of mixed electrode materials are analyzed...
May 17, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28511934/repeated-manganese-administration-produced-abnormal-expression-of-circadian-clock-genes-in-the-hypothalamus-and-liver-of-rats
#11
Huan Li, Ximin Fan, Ying Luo, Sheng Song, Jie Liu, Qiyuan Fan
Manganese (Mn) neurotoxicity displays non-motor dysfunction and motor impairment like Parkinson's disease (PD), and is called as Manganism. Circadian disruption is a non-motor symptom found in PD and Manganism. Clock genes are essential to drive and maintain circadian rhythm, but little is known about Mn exposure on circadian clock genes expression. Both the brain and liver are targets of Mn, we hypothesize that repeated Mn administration could affect clock gene expression in the hypothalamus and livers. Male Sprague-Dawley rats were intraperitoneally injected Mn(2+) 1mg and 5mg/kg as MnCl2·4H2O, every other day for 30 days...
May 13, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28500793/integrating-the-genomic-architecture-of-human-nucleolar-organizer-regions-with-the-biophysical-properties-of-nucleoli
#12
REVIEW
Hazel Mangan, Michael Ó Gailín, Brian McStay
Nucleoli are the sites of ribosome biogenesis and the largest membraneless sub-nuclear structures. They are intimately linked with growth and proliferation control and function as sensors of cellular stress. Nucleoli form around arrays of ribosomal gene (rDNA) repeats also called nucleolar organizer regions (NORs). In humans, NORs are located on the short arms of all five human acrocentric chromosomes. Multiple NORs contribute to the formation of large heterochromatin-surrounded nucleoli observed in most human cells...
May 13, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28484760/comparison-of-nucleophilic-and-radical-based-routes-to-the-formation-of-manganese-main-group-element-single-bonds
#13
Douglas W Agnew, Curtis E Moore, Arnold L Rheingold, Joshua S Figueroa
Using the stable metalloradical Mn(CO)3(CNAr(Dipp2))2, we report the formation of manganese-main group complexes via the single-electron functionalization of main group halides. The reactions occur in a simple 1 : 1 stoichiometry, and demonstrate the utility of using stable open-shelled organometallics as precursors for metal-main group compounds. This has enabled the preparation of manganese complexes bearing terminal -EXn substituents, as shown through the isolation of Mn(SnCl)(CO)3(CNAr(Dipp2))2 and Mn(BiCl2)(CO)3(CNAr(Dipp2))2 from SnCl2 and BiCl3, respectively...
May 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28479240/fesoterodine-for-the-treatment-of-nocturnal-urgency-in-patients-with-overactive-bladder-syndrome-an-analysis-of-responders-and-non-responders
#14
Johnathan A Khusid, Jeffrey P Weiss, Martin O Carlsson, Erin K Mangan
PURPOSE: A recent study demonstrated improvement of nocturnal urgency in patients with overactive bladder (OAB) when treated with fesoterodine. The current study aims to determine which bladder diary parameters predict response to fesoterodine in these patients. MATERIALS AND METHODS: Patients with nocturnal urgency completed a 2-week, single-blind, placebo run-in, followed by 1:1 double-blind randomization to 12 weeks of fesoterodine or placebo. We analysed changes from baseline to week 12 of bladder diary parameters including actual number night voids (ANV, total # nocturia episodes), maximum voided volume (MVV), nocturnal bladder capacity (NBC), nocturnal bladder capacity index (NBCi = ANV- NUV/MVV-1), nocturnal urine volume (NUV), nocturia index (Ni = NUV/MVV), nocturnal polyuria index and (NPi = NUV/24 hour volume)...
May 4, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28475631/a-systems-level-model-reveals-that-1-2-propanediol-utilization-microcompartments-enhance-pathway-flux-through-intermediate-sequestration
#15
Christopher M Jakobson, Danielle Tullman-Ercek, Marilyn F Slininger, Niall M Mangan
The spatial organization of metabolism is common to all domains of life. Enteric and other bacteria use subcellular organelles known as bacterial microcompartments to spatially organize the metabolism of pathogenicity-relevant carbon sources, such as 1,2-propanediol. The organelles are thought to sequester a private cofactor pool, minimize the effects of toxic intermediates, and enhance flux through the encapsulated metabolic pathways. We develop a mathematical model of the function of the 1,2-propanediol utilization microcompartment of Salmonella enterica and use it to analyze the function of the microcompartment organelles in detail...
May 5, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28460583/subchronic-low-level-intraperitoneal-injections-of-manganese-iv-oxide-and-manganese-ii-chloride-affect-rat-brain-neurochemistry
#16
Brian S Nielsen, Erik H Larsen, Ole Ladefoged, Henrik R Lam
Manganese (Mn) is neurotoxic and can induce manganism, a Parkinson-like disease categorized as being a serious central nervous system irreversible neurodegenerative disease. An increased risk of developing symptoms of Parkinson disease has been linked to work-related exposure, for example, for workers in agriculture, horticulture, and people living near areas with frequent use of Mn-containing pesticides. In this study, the focus was placed on neurochemical effects of Mn. Rats were dosed intraperitoneally with 0...
January 1, 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/28449375/the-genetic-dimension-of-pest-pressure-in-the-tropical-rainforest
#17
Marco Todesco, Quentin Cronk
Wet tropical forests are among the most diverse ecosystems on Earth and can host several hundreds of tree species per hectare. To maintain such diversity, the community must contain large numbers of relatively rare species rather than be dominated by a few very common trees, as is often the case in temperate forests. Explaining the mechanisms preventing dominance by common species has been a major task of tropical forest ecology. One of the most promising mechanisms is negative density dependence (NDD) of tree abundance driven by pests, including fungal diseases ('pest pressure')...
May 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28416395/the-early-history-of-manganese-and-the-recognition-of-its-neurotoxicity-1837-1936
#18
Paul D Blanc
The history of the biomedical recognition manganese-caused neurotoxicity mirrors changing technologies as much as it does the ontology of parkinsonism. The initial 1837 report of manganese-induced neurologic injury was made by John Couper, a university-based physician in Scotland. He made clear that the outbreak occurred among workers at the Charles Tennant bleach manufactory in the environs of Glasgow. The relatively new technology of chlorine generation using manganese accounted for the novel exposure involved...
April 14, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28399974/evaluation-of-the-tuberculosis-infection-control-training-center-tajikistan-2014-2015
#19
C Scott, J Mangan, Z Tillova, P A Jensen, S Ahmedov, J Ismoilova, A Trusov
SETTING: Training center on tuberculosis (TB) infection control (IC) for health care workers in the Central Asian Republics region. OBJECTIVE: To assess the effects of TB IC training courses conducted at the Tuberculosis Infection Control Training Center in Machiton, Tajikistan. DESIGN: Participants who participated in training (n = 89) during the first year of operation (April 2014-February 2015) were invited to participate in a post-training interview...
May 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28394286/sodium-p-aminosalicylic-acid-reverses-sub-chronic-manganese-induced-impairments-of-spatial-learning-and-memory-abilities-in-rats-but-fails-to-restore-%C3%AE-aminobutyric-acid-levels
#20
Shao-Jun Li, Chao-Yan Ou, Sheng-Nan He, Xiao-Wei Huang, Hai-Lan Luo, Hao-Yang Meng, Guo-Dong Lu, Yue-Ming Jiang, Tanara Vieira Peres, Yi-Ni Luo, Xiang-Fa Deng
Excessive manganese (Mn) exposure is not only a health risk for occupational workers, but also for the general population. Sodium para-aminosalicylic acid (PAS-Na) has been successfully used in the treatment of manganism, but the involved molecular mechanisms have yet to be determined. The present study aimed to investigate the effects of PAS-Na on sub-chronic Mn exposure-induced impairments of spatial learning and memory, and determine the possible involvements of γ-aminobutyric acid (GABA) metabolism in vivo...
April 10, 2017: International Journal of Environmental Research and Public Health
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