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https://www.readbyqxmd.com/read/29327718/epithelioid-fibrous-histiocytoma-molecular-characterization-of-alk-fusion-partners-in-23-cases
#1
Brendan C Dickson, David Swanson, George S Charames, Christopher Dm Fletcher, Jason L Hornick
Epithelioid fibrous histiocytoma is a rare and distinctive cutaneous neoplasm. Most cases harbor ALK rearrangement and show ALK overexpression, which distinguish this neoplasm from conventional cutaneous fibrous histiocytoma and variants. SQSTM1 and VCL have previously been shown to partner with ALK in one case each of epithelioid fibrous histiocytoma. The purpose of this study was to examine a large cohort of epithelioid fibrous histiocytomas by next-generation sequencing to characterize the nature and prevalence of ALK fusion partners...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29323061/accuracy-of-vascular-invasion-reporting-in-hepatocellular-carcinoma-before-and-after-implementation-of-subspecialty-surgical-pathology-sign-out
#2
Aaron R Huber, Raul S Gonzalez, Mark S Orloff, Christopher T Barry, Christa L Whitney-Miller
CONTEXT: Liver cancers (including hepatocellular carcinoma [HCC] and cholangiocarcinoma) are the fifth most common cause of cancer death. The most powerful independent histologic predictor of overall survival after transplantation for HCC is the presence of microscopic vascular invasion (VI). AIMS: Given that VI is known to have somewhat high interobserver variability in both HCC and other tumors, we hypothesized that pathologists with special interest and training in liver pathology would be more likely to identify and report VI in HCC than would general surgical pathologists...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29320324/spectrum-of-coronary-artery-aneurysms-from-the-radiologic-pathology-archives
#3
Jean Jeudy, Charles S White, Seth J Kligerman, Jonathan L Killam, Allen P Burke, Jacob W Sechrist, Amar B Shah, Rydhwana Hossain, Aletta Ann Frazier
Advances in medical diagnosis reveal that coronary artery aneurysms (CAAs) may develop in several clinical scenarios and manifest variable symptoms, imaging appearances, and outcomes. Aneurysms are pathologically classified into three groups: atherosclerotic, inflammatory, and noninflammatory. The last category is associated with congenital, inherited, and connective tissue disorders. Overlap exists among the groups, because secondary atherosclerotic change may be present in an aneurysm of any cause. Atherosclerosis is the most common cause of CAAs in adults, and inflammation is considered the underlying mechanism...
January 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29304781/evaluation-of-endoglin-cd105-expression-in-pediatric-rhabdomyosarcoma
#4
Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano, Angela Di Giannatale
BACKGROUND: The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly expressed in proliferating endothelium and the IMVD determined by this marker measures specifically the neovascularization. In this study, we investigated the CD105 expression in pediatric rhabdomyosarcoma and assessed the neovascularization by using the angiogenic ratio IMVD-CD105 to IMVD-CD31...
January 5, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29302284/adenomatoid-odontogenic-tumor-case-series-of-14-with-wide-range-of-clinical-presentation
#5
Fatima Al-Shimari, Srinivasa Chandra, Dolphine Oda
Background: To present 14 cases of adenomatoid odontogenic tumor (AOT), highlighting their clinical, radiographic, and histologic characteristics. Material and Methods: Fourteen cases of AOT were retrieved from the archives of the Oral Pathology Biopsy Service (OPBS). Clinical, radiologic, and histologic findings are described. Results: Fourteen AOT cases were reviewed, of which 12 were intraosseous and two were peripheral (gingiva). The cases came from eight females and six males with an age range of 11-30...
November 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29288495/pan-cancer-insights-from-the-cancer-genome-atlas-the-pathologist-s-perspective
#6
REVIEW
Lee A D Cooper, Elizabeth G Demicco, Joel H Saltz, Reid T Powell, Arvind Rao, Alexander J Lazar
The Cancer Genome Atlas (TCGA) represents one of several international consortia dedicated to performing comprehensive genomic and epigenomic analyses of selected tumor types to advance understanding of disease and provide an open-access resource for worldwide cancer research. Thirty-three tumor types (selected by histology or tissue of origin, to include both common and rare diseases), comprising over 11,000 specimens were subjected to DNA sequencing, copy number and methylation analysis, and transcriptomic, proteomic, and histologic evaluation...
December 30, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29286578/rna-expression-profiling-of-renal-allografts-in-a-non-human-primate-identifies-variation-in-nk-and-endothelial-gene-expression
#7
R N Smith, B A Adam, I A Rosales, M Matsunami, T Oura, A B Cosimi, T Kawai, M Mengel, R B Colvin
RNA transcript expression estimates are a promising method to study the mechanisms and classification of renal allograft rejections. Here we use the Nanostring platform to profile RNA expression in renal allografts in a non-human primate (NHP), the Cynomolgus monkey. We analyzed protocol and indication 278 archival renal allograft samples, both protocol and indication from 76 animals with diagnoses of chronic antibody (CAMR), acute cellular rejection (TCMR) and MIXED (both CAMR and TCMR), plus normals and samples with no pathological rejection using a Cynomolgus specific probe set of 67 genes...
December 29, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29248496/clinical-and-histopathological-features-of-nasopalatine-duct-cyst-a-47-year-retrospective-study-and-review-of-current-concepts
#8
Caio César da Silva Barros, Hellen Bandeira de Pontes Santos, Israel Leal Cavalcante, Larissa Santos Amaral Rolim, Leão Pereira Pinto, Lélia Batista de Souza
PURPOSE: To evaluate the clinical and histopathological features of nasopalatine duct cysts (NDCs) stored in the archives of a referred Oral Pathology Service over a 47-year-period, and to review current concepts about these cysts. MATERIAL AND METHODS: All NDCs were reviewed, and clinical data were obtained from the patient records. Thirty cases were re-evaluated microscopically by 2 oral pathologists. RESULTS: Among 14,564 cases, 30 (0.20%) were NDCs...
December 2, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29247621/peripheral-ameloblastoma-a-study-of-18-cases-and-usage-of-ber-ep4-immunohistochemistry-to-rule-out-a-diagnosis-of-intraoral-basal-cell-carcinoma
#9
Jasbir D Upadhyaya, Indraneel Bhattacharyya, Sarah G Fitzpatrick, Donald M Cohen, Mohammed N Islam
PURPOSE: Peripheral ameloblastoma (PA) is a rare odontogenic tumor arising in the mucosa of tooth-bearing areas of the jaws that typically shows no radiographic evidence of bone involvement. It bears close histologic resemblance to intraoral basal cell carcinoma (IOBCC), an extremely rare entity. In our experience from previous published data, 3 cases of IOBCC were initially misdiagnosed as PA and were later differentiated from PA on the basis of Ber-EP4 protein expression. This unusual but significant experience set the premise for us to rule out a diagnosis of IOBCC by evaluating Ber-EP4 expression in all previously diagnosed cases of PA from the University of Florida Oral Pathology (UFOP) biopsy service archives...
November 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29243545/the-role-of-macrophages-in-the-differentiation-process-of-ureteral-polyps
#10
Yue-Hui Wang, Tian-Qi Zhang, Ji-Ning Fu, Ying Liu, Hai-Yan Jia
Objective To evaluate the role of macrophage infiltration in the differentiation process of ureteral polyps and cancers. Methods This retrospective immunohistochemical study analysed archival samples of pathologically-confirmed specimens of low- and high-grade ureteral cancer, ureteral papilloma and ureteral polyps. The samples were immunohistochemically stained for cluster of differentiation (CD)4, CD8, CD16, CD25, CD56 and CD68 using immunofluorescence in order to identify different T-lymphocyte populations and macrophages...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29241972/towards-machine-learned-quality-control-a-benchmark-for-sharpness-quantification-in-digital-pathology
#11
Gabriele Campanella, Arjun R Rajanna, Lorraine Corsale, Peter J Schüffler, Yukako Yagi, Thomas J Fuchs
Pathology is on the verge of a profound change from an analog and qualitative to a digital and quantitative discipline. This change is mostly driven by the high-throughput scanning of microscope slides in modern pathology departments, reaching tens of thousands of digital slides per month. The resulting vast digital archives form the basis of clinical use in digital pathology and allow large scale machine learning in computational pathology. One of the most crucial bottlenecks of high-throughput scanning is quality control (QC)...
September 25, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29238890/real-time-detection-of-braf-v600e-mutation-from-archival-hairy-cell-leukemia-ffpe-tissue-by-nanopore-sequencing
#12
Davide Vacca, Valeria Cancila, Alessandro Gulino, Giosuè Lo Bosco, Beatrice Belmonte, Arianna Di Napoli, Ada Maria Florena, Claudio Tripodo, Walter Arancio
The MinION is a miniaturized high-throughput next generation sequencing platform of novel conception. The use of nucleic acids derived from formalin-fixed paraffin-embedded samples is highly desirable, but their adoption for molecular assays is hurdled by the high degree of fragmentation and by the chemical-induced mutations stemming from the fixation protocols. In order to investigate the suitability of MinION sequencing on formalin-fixed paraffin-embedded samples, the presence and frequency of BRAF c.1799T > A mutation was investigated in two archival tissue specimens of Hairy cell leukemia and Hairy cell leukemia Variant...
December 13, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/29235614/techniques-for-maximizing-the-performance-of-molecular-pathology-testing-responsibilities-of-all-pathologists
#13
Evren Uzun, Sülen Sarioğlu
Molecular pathological analysis has an expanding role in patient diagnosis and management. The performance of these techniques relies on excellent laboratory procedures. However, the crucial step is obtaining the best samples for molecular analysis. Archiving and selection of these are the responsibilities of all pathologists even if they are not working at a center with molecular pathological facilities. This review focuses on the features of different types of materials for molecular pathological analysis...
December 13, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29225921/geo-epidemiology-of-temporal-artery-biopsy-positive-giant-cell-arteritis-in-australia-and-new-zealand-is-there-a-seasonal-influence
#14
Elisabeth De Smit, Linda Clarke, Paul G Sanfilippo, Tony R Merriman, Matthew A Brown, Catherine L Hill, Alex W Hewitt
Objective: Previous studies, although inconclusive, have suggested possible associations of environmental risk factors with the development of giant cell arteritis (GCA). We aim to investigate seasonal influence on the incidence of GCA across Australia and New Zealand. Methods: In establishing an international study to investigate the molecular aetiology of GCA, archived temporal artery biopsy (TAB) specimens primarily from Australia and New Zealand were obtained...
2017: RMD Open
https://www.readbyqxmd.com/read/29213282/determination-of-mammalian-target-of-rapamycin-hyperactivation-as-prognostic-factor-in-well-differentiated-neuroendocrine-tumors
#15
G Lamberti, C Ceccarelli, N Brighi, I Maggio, D Santini, C Mosconi, C Ricci, G Biasco, D Campana
Purpose: To evaluate the role of the activation of mTOR (phosphorylated mTOR, p-mTOR) and the expression SSTR2A and IGF-1R as prognostic factor in well-differentiated neuroendocrine tumors. Methods: A retrospective study was conducted on data from patients with diagnosis of neuroendocrine tumor originated from pancreas (pNET) or gastrointestinal tract (stomach, appendix, and ileus; GI-NET) made between January 2003 and December 2004 and followed up at our institution...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29208591/the-second-look-procedure-for-transoral-videolaryngoscopic-surgery-for-t1-and-t2-laryngeal-oropharyngeal-and-hypopharyngeal-cancer-patients-protocol-for-a-nonrandomized-clinical-trial
#16
Goshi Nishimura, Daisuke Sano, Kenichiro Yabuki, Yasuhiro Arai, Yoshihiro Chiba, Teruhiko Tanabe, Nobuhiko Oridate
BACKGROUND: Transoral videolaryngoscopic surgery (TOVS) has been widely applied for early T stage head and neck cancer. The resection is performed with a minimum safety margin for function preservation under a limited surgical field of view, making it difficult to be certain of complete resection. OBJECTIVE: Our aim is the evaluation of the completeness of resection by initial TOVS resection, and the possibility of primary control by TOVS alone, allowing for repeat procedures for function preserving treatment in early T stage laryngeal, oropharyngeal, and hypopharyngeal cancer patients...
December 5, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/29202611/aurora-kinase-a-as-a-possible-marker-for-endocrine-resistance-in-early-estrogen-receptor-positive-breast-cancer
#17
Anne E Lykkesfeldt, Benedikte R Iversen, Maj-Britt Jensen, Bent Ejlertsen, Anita Giobbie-Hurder, Birgit E Reiter, Tove Kirkegaard, Birgitte B Rasmussen
BACKGROUND: Cell culture studies have disclosed that the mitotic Aurora kinase A is causally involved in both tamoxifen and aromatase inhibitor resistant cell growth and thus may be a potential new marker for endocrine resistance in the clinical setting. MATERIAL AND METHODS: Archival tumor tissue was available from 1323 Danish patients with estrogen receptor (ER) positive primary breast cancer, who participated in the Breast International Group (BIG) 1-98 trial, comparing treatment with tamoxifen and letrozole and both in a sequence...
December 4, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29193461/site-specific-gene-expression-analysis-from-archived-human-intestine-samples-combining-laser-capture-microdissection-and-multiplexed-color-coded-probes
#18
A Braun, C Martinez, S Schmitteckert, R Röth, F Lasitschka, B Niesler
BACKGROUND: Alterations of site-specific gene expression profiles in disease-relevant networks within the different layers of the intestinal wall may contribute to the onset and clinical course of gastrointestinal disorders. To date, no systematic analysis has assessed and compared sub-regional gene expression patterns in all distinct layers of the gut using fresh frozen human samples. Our aim was to establish an optimized protocol for site-specific RNA isolation in order to achieve maximum RNA quality and amount for subsequent gene expression analysis combining laser-capture microdissection (LCM) with a probe-based technology, the NanoString nCounter Analysis system...
November 28, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29193313/estimating-the-number-of-potential-family-members-eligible-for-brca1-and-brca2-mutation-testing-in-a-traceback-approach
#19
Haley A Moss, Goli Samimi, Laura J Havrilesky, Mark E Sherman, Evan R Myers
U.S. guidelines recommend BRCA1/2 mutation testing for women diagnosed with high-grade ovarian cancer (HGOC) to increase recognition of carriers, but most remain unidentified and at risk. Accordingly, an approach termed "Traceback" has been proposed in which probands are retrospectively identified by testing archived pathology specimens, and family members are traced to provide genetic counseling and testing. We used population-based data to estimate the number of family members who might be contacted through such a program...
November 30, 2017: Genetic Epidemiology
https://www.readbyqxmd.com/read/29193072/syphilis-cardiovascular-manifestations-of-the-great-imitator
#20
Roger W Byard
Rates of syphilis are beginning to once again increase, with the World Health Organization estimating that in recent years there were 12 million new cases of syphilis each year; in 2002, syphilis was responsible for 0.3% of deaths globally. At-risk groups include young males (20-29 years), prisoners, and sex workers. Increased rates in young females have elevated the numbers of congenital cases. Review of the University of Adelaide Pathology Archive revealed four cases with significant pathology, which included cardiac gummas and aortic arch aneurysms...
November 28, 2017: Journal of Forensic Sciences
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