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https://www.readbyqxmd.com/read/28934684/scientific-evidence-for-the-identification-of-an-aboriginal-massacre-at-the-sturt-creek-sites-on-the-kimberley-frontier-of-north-western-australia
#1
Pamela A Smith, Mark D Raven, Keryn Walshe, Robert W Fitzpatrick, F Donald Pate
Archival research into episodes of frontier violence in the Kimberley region of Western Australia indicate that the bodies of Aboriginal victims of massacres were frequently incinerated following the event. This paper presents the results of a scientific investigation of a reported massacre at Sturt Creek where burnt bone fragments were identified in two adjacent sites and documents the archaeological signatures associated with the sites. The methodology used to undertake the project brought together three systems of knowledge: the oral testimonies of the descent group originating from a sole adult survivor of the massacre; archival, historical and scientific research...
August 31, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28933246/double-outlet-right-ventricle-with-right-sided-aorta-from-the-left-sided-morphologically-right-ventricle-in-the-setting-of-discordant-atrioventricular-connections
#2
Sachin Talwar, Robert H Anderson, Amolkumar Bhoje, Adrian Crucean, Saurabh Kumar Gupta, Shiv Kumar Choudhary, Balram Airan
We describe the anatomic findings in a 2-year-old patient with double outlet right ventricle with right-sided aorta in the setting of usual atrial arrangement and discordant atrioventricular connections, making comparison with a specimen from the pathological archive of the Birmingham Children's Hospital in the United Kingdom having this rare combination of anatomic features. We discuss the challenges involved in diagnosis and management.
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28932033/glandular-odontogenic-cyst-series-of-five-cases
#3
Aadithya B Urs, Priya Kumar, Jeyaseelan Augustine, Rewa Malhotra
INTRODUCTION: Glandular odontogenic cyst (GOC) is a clinically rare and histopathologically unusual type of developmental odontogenic cyst with unpredictable and potentially aggressive behaviour. MATERIALS AND METHODS: Archival data of cases histopathologically identified as GOC were analyzed from the Department of Oral Pathology over the past six years. The clinical, radiographic, histopathological features and treatment were evaluated. Special stains such as periodic acid Schiff, mucicarmine along with immunohistochemical staining for cytokeratin 19 were employed to confirm the histopathological diagnosis...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28920482/fowl-aviadenovirus-serotype-1-confirmed-as-the-aetiological-agent-of-gizzard-erosions-in-replacement-pullets-and-layer-flocks-in-great-britain-by-laboratory-and-in-vivo-studies
#4
Beatrice Grafl, Cristina Garcia-Rueda, Peter Cargill, Alisdair Wood, Alex Schock, Dieter Liebhart, Anna Schachner, Michael Hess
An investigation into the aetiology and pathogenesis of adenoviral gizzard erosion has been conducted following three natural outbreaks affecting one flock of 6-week-old replacement pullets and two consecutive placements of free range layers at the age of 21 and 23 weeks. Affected flocks showed increased mortality (0.12-0.30% per week), and gizzard lesions were consistent with fowl aviadenovirus (FAdV) involvement. To substantiate the initial findings, a selection of archived formalin-fixed paraffin-embedded gizzard samples from another 12 pullet and layer flocks, for which macroscopic and histopathological diagnosis of the disease were recorded in Great Britain during the period 2009-2016, were also investigated...
September 18, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28903876/persistence-of-mycoplasma-hyopneumoniae-sequence-types-in-spite-of-a-control-program-for-enzootic-pneumonia-in-pigs
#5
Gudrun Overesch, Peter Kuhnert
Enzootic pneumonia (EP) in pigs caused by Mycoplasma (M.) hyopneumoniae has successfully been combatted in Switzerland. A control program was fully implemented in 2004 which is based on total depopulation strategies of affected fattening farms as well as partial depopulation on breeding farms. Thereby, the number of cases has dropped drastically from more than 200 in 2003 to two cases in 2013. Currently monitoring is done based on clinical observation and subsequent diagnostic of coughing pigs. Moreover, in case of more than 10% gross pathological lesions per slaughter batch laboratory confirmation for EP is compulsory...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28902812/-the-use-nicergoline-in-the-treatment-of-diabetes-mellitus
#6
I V Popova, A A Karpenko
Presented herein is a literature review aimed at investigating the appropriateness and possibility of using nicergoline (sermion) for treatment of patients suffering from diabetes mellitus. The analysis includes the most clinically significant results of scientific studies. The material to be reviewed was retrieved using the following key words: 'nicergoline', 'sermion', and 'diabetes mellitus' (with their respective Russian equivalents) in such databases as Medline, PubMed, ScienceDirect, PMC, Cochrane, as well as archives of both Russian and foreign journals, guidelines (clinical guidelines on rendering medical care for patients with diabetes mellitus, selected lectures on endocrinology)...
2017: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/28899352/integrator-complex-subunit-6-ints6-inhibits-hepatocellular-carcinoma-growth-by-wnt-pathway-and-serve-as-a-prognostic-marker
#7
Ka Yin Lui, Hui Zhao, Chunhui Qiu, Chuo Li, Zhigang Zhang, Haoran Peng, Rongdang Fu, Hu-An Chen, Min-Qiang Lu
BACKGROUND: Integrator complex subunit 6 (INTS6) was found to play a tumour suppressing role in certain types of solid tumours. In this study, we wanted to determine the expression level of INTS6 in hepatocellular carcinoma (HCC) and evaluate its clinical characteristics and mechanisms in HCC patients (Lui and Lu, European Journal of Cancer, 51:S94, 2015). METHODS: First, we used a microarray analysis to explore the mRNA expression levels in HCC and paired normal liver tissues; second, we used qRT-PCR to measure the INTS6 mRNA levels in a cohort of 50 HCC tissues and adjacent normal liver tissues; third, we used Western blot analyses to detect the INTS6 protein levels in 20 paired HCC and normal liver tissues; fourth, we used immunohistochemistry to determine the INTS6 expression levels in 70 archived paraffin-embedded HCC samples...
September 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28898190/renal-tumors-of-childhood-radiologic-pathologic-correlation-part-2-the-2nd-decade-from-the-radiologic-pathology-archives
#8
Ellen M Chung, Grant E Lattin, Kimberly E Fagen, Andrew M Kim, Michael A Pavio, Adam J Fehringer, Richard M Conran
Malignant renal tumors account for 7% of childhood cancers, and Wilms tumors are by far the most common-but not in older children and adolescents. Among individuals in the latter half of their 2nd decade of life, renal cell carcinoma (RCC) is more common than Wilms tumor. The histopathologic spectrum of RCCs in children differs from that in adults. The most common subtype of RCC in children and adolescents is Xp11.2 translocation RCC, which is distinguished by hyperattenuation at nonenhanced computed tomography, a defined capsule, and associated retroperitoneal lymphadenopathy...
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28894572/comparison-between-digital-and-optical-microscopy-analysis-in-a-mouse-gut-inflammation-model
#9
Airton Pereira E Silva, Sylvia Maria Nicolau Campos, Isabelle Mazza Guimarães, Gerlinde Agate Platais Brasil Teixeira
Virtual microscopy is currently widely used for various purposes, such as teaching, archiving, collaborations and research. Although the cost of this technique has reduced, it continues to be expensive for the majority of laboratories in developing countries. The Graduate Program in Pathology at the Federal Fluminense University (Niterói, Brazil) has acquired equipment for virtual microscopy. However, this novel method faced prejudice, as students and technicians were skeptical about its reliability. Thus, the aim of the current study was to evaluate whether virtual microscopy is a reliable method of analysis for our research...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28891390/pathology-and-epidemiology-of-oxalate-nephrosis-in-cheetahs
#10
Emily P Mitchell, Molly E Church, Sarah M Nemser, Betsy Jean Yakes, Eric R Evans, Renate Reimschuessel, Karin Lemberger, Peter N Thompson, Karen A Terio
To investigate cases of acute oxalate nephrosis without evidence of ethylene glycol exposure, archived data and tissues from cheetahs ( Acinonyx jubatus) from North America ( n = 297), southern Africa ( n = 257), and France ( n = 40) were evaluated. Renal and gastrointestinal tract lesions were characterized in a subset of animals with ( n = 100) and without ( n = 165) oxalate crystals at death. Crystals were confirmed as calcium oxalate by Raman spectroscopy in 45 of 47 cheetahs tested. Crystals were present in cheetahs from 3...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/28891048/identifying-actionable-variants-using-next-generation-sequencing-in-patients-with-a-historical-diagnosis-of-undifferentiated-pleomorphic-sarcoma
#11
Jeremy Lewin, Swati Garg, Beatrice Y Lau, Brendan C Dickson, Frank Traub, Nalan Gokgoz, Anthony M Griffin, Peter C Ferguson, Irene L Andrulis, Hao-Wen Sim, Suzanne Kamel-Reid, Tracy L Stockley, Lillian Siu, Jay S Wunder, Albiruni Ra Razak
There are limited data regarding the molecular characterization of undifferentiated pleomorphic sarcomas (UPS; formerly malignant fibrous histiocytoma). This study aimed to investigate the utility of next generation sequencing (NGS) in UPS to identify subsets of patients who harbour actionable mutations. Patients diagnosed with UPS underwent pathological re-evaluation by a pathologist specializing in sarcoma. Tumor DNA was isolated from archived fresh frozen tissue samples and genotyped using NGS with the Illumina MiSeq TruSeq Amplicon Cancer Panel (48 genes, 212 amplicons)...
September 10, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28874886/in-search-for-optimal-targets-for-intraoperative-fluorescence-imaging-of-peritoneal-metastasis-from-colorectal-cancer
#12
Charlotte Es Hoogstins, Benjamin Weixler, Leonora Sf Boogerd, Diederik J Hoppener, Hendrica Ajm Prevoo, Cornelis Fm Sier, Jacobus Wa Burger, Cornelis Verhoef, Shadvhi Bhairosingh, Arantza Farina Sarasqueta, Jacobus Burggraaf, Alexander L Vahrmeijer
Peritoneal metastasis (PM) occurs in about 10% of patients with colorectal cancer (CRC). Fluorescence imaging can enhance contrast between cancerous and benign tissue, enabling the surgeon to clearly visualize PM during cytoreductive surgery. This study assessed the suitability of different biomarkers as potential targets for tumor-targeted imaging of PM of CRC. Tissue samples from primary tumor and PM from patients with CRC were obtained from the pathology archives and immunohistochemical stainings were performed...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28871375/walter-e-dandy-his-contributions-to-pituitary-surgery-in-the-context-of-the-overall-johns-hopkins-hospital-experience
#13
Andrea Corsello, Giulia Di Dalmazi, Fabiana Pani, Paulina Chalan, Roberto Salvatori, Patrizio Caturegli
BACKGROUND: Walter E. Dandy (1886-1946) was an outstanding neurosurgeon who spent his entire career at the Johns Hopkins Hospital. After graduating from medical school in 1910, he completed a research fellowship in the Hunterian laboratory with Harvey Cushing and then joined the Department of Surgery as resident, rising to the rank professor in 1931. Dandy made several contributions that helped building the neurosurgical specialty, most famously the introduction of pneumo-ventriculography to image brain lesions for which he received a Nobel prize nomination...
September 4, 2017: Pituitary
https://www.readbyqxmd.com/read/28861354/epstein-barr-virus-encoded-small-rnas-in-idiopathic-orbital-inflammatory-pseudotumor-tissues-a-comparative-case-series
#14
Min-Wei Ren, Yi Du, Shan Ren, Cheng-Ye Tang, Jian-Feng He
AIM: To investigate the positive rate and types of cells that express Epstein-Barr virus-encoded small RNAs (EBERs) and to determine the distribution of EBER-expressing cells in idiopathic orbital inflammatory pseudotumor (IOIP) tissues. METHODS: We retrospectively examined 40 archived paraffin specimens from two teaching hospitals in Southern China between January 2007 and January 2015 that were pathologically determined to exhibit IOIP. Eleven concurrent paraffin specimens of thyroid-associated ophthalmopathy (TAO) composed the control group...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28859116/the-sommersdorf-mummies-an-interdisciplinary-investigation-on-human-remains-from-a-17th-19th-century-aristocratic-crypt-in-southern-germany
#15
Amelie Alterauge, Manuel Kellinghaus, Christian Jackowski, Natallia Shved, Frank Rühli, Frank Maixner, Albert Zink, Wilfried Rosendahl, Sandra Lösch
Sommersdorf Castle (Bavaria, Germany) is a medieval castle complex which has been inhabited by the aristocratic family von Crailsheim. The deceased were entombed in a crypt located in the parapets underneath the castle's church, resulting in mummification of the bodies. Based on the family chronicle and oral history, identities have been ascribed to the mummies. The aim of the study is therefore to test the accuracy of the historical records in comparison to archaeological, anthropological and genetic data...
2017: PloS One
https://www.readbyqxmd.com/read/28858097/how-frequent-is-osteogenesis-imperfecta-in-patients-with-idiopathic-osteoporosis-case-reports
#16
Ali Al Kaissi, Christian Windpassinger, Farid Ben Chehida, Maher Ben Ghachem, Nabil M Nassib, Vladimir Kenis, Eugene Melchenko, Ekatrina Morenko, Sergey Ryabykh, Jochen G Hofstaetter, Franz Grill, Rudolf Ganger, Susanne Gerit Kircher
RATIONALE: The term idiopathic osteoporosis itself is quite a non-specific disease label, which fails to address the etiological understanding. Bone mineral density alone is not a reliable parameter to detect patients at high risk of fracture. The diversity of the clinical phenotypes of discolored teeth, blueness of the sclera, back and joint pain, cardiovascular disease, Diabetes type II, hearing problems and a long list of orthopedic problems are have to be considered. PATIENTS CONCERNS: Our study has been designed in accordance with the clinical and radiological phenotype of eleven index cases with the provisional diagnosis of OI, which was followed by genotypic confirmation...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28855268/inflammatory-infiltrates-in-parathyroid-tumors
#17
Felix Haglund, Björn Hallström, Inga-Lena Nilsson, Anders HÖÖg, Christofer C Juhlin, Catharina Larsson
Context Inflammatory infiltrates are sometimes present in solid tumors and may be coupled to clinical behavior or etiology. Infectious viruses contribute to tumorigenesis in a significant fraction of human neoplasias. Objective Characterize inflammatory infiltrates and possible viral transcription in primary hyperparathyroidism. Design From the period 2007-2016, a total of 55 parathyroid tumors (51 adenomas and 4 hyperplasias) with prominent inflammatory infiltrates were identified from more than 2000 parathyroid tumors in the pathology archives, and investigated by immunohistochemistry for CD4, CD8, CD20 and CD45 and scored as +0, +1 or +2...
August 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28854346/abstract-case-study-review-committee-for-the-college-of-american-pathologists-2017-annual-meeting-cap17
#18
(no author information available yet)
The Archives of Pathology & Laboratory Medicine acknowledges the following individuals for volunteering to review abstract and case study submissions for the CAP17 meeting.
September 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28839164/cubic-pathology-three-dimensional-imaging-for-pathological-diagnosis
#19
Satoshi Nojima, Etsuo A Susaki, Kyotaro Yoshida, Hiroyoshi Takemoto, Naoto Tsujimura, Shohei Iijima, Ko Takachi, Yujiro Nakahara, Shinichiro Tahara, Kenji Ohshima, Masako Kurashige, Yumiko Hori, Naoki Wada, Jun-Ichiro Ikeda, Atsushi Kumanogoh, Eiichi Morii, Hiroki R Ueda
The examination of hematoxylin and eosin (H&E)-stained tissues on glass slides by conventional light microscopy is the foundation for histopathological diagnosis. However, this conventional method has some limitations in x-y axes due to its relatively narrow range of observation area and in z-axis due to its two-dimensionality. In this study, we applied a CUBIC pipeline, which is the most powerful tissue-clearing and three-dimensional (3D)-imaging technique, to clinical pathology. CUBIC was applicable to 3D imaging of both normal and abnormal patient-derived, human lung and lymph node tissues...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28832083/a-unique-immunofluorescence-protocol-to-detect-protein-expression-in-vascular-tissues-tacking-a-long-standing-pathological-hitch
#20
Puneet Gandhi, Richa Khare
OBJECTIVE: Autofluorescence induced interference is one of the major drawbacks in immunofluorescence analysis of formalin-fixed paraffin-embedded tissues, as it decreases the signal-to-noise ratio of specific labeling. Apart from aldehyde-fixation induced artifacts; collagen and elastin, red blood cells and endogenous fluorescent pigment lipofuscin are prime sources of autofluorescence in vascular and aging tissues. We describe herein, an optimized indirect-immunofluorescence method for archival formalin-fixed paraffin-embedded tissues tissues and cryo sections, using a combination of 3-reagents in a specific order, to achieve optimal fluorescence signals and imaging...
2017: Türk Patoloji Dergisi
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