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archives of pathology

E Dagan, R Gershoni-Baruch, A Kurolap, G Fried
This study uncovers disease characteristics by long-term follow-up in Ashkenazi early onset breast cancer (EOBC) patients, carriers of founder BRCA1/2 mutations compared to non-carriers of such mutations. An archives-retrospective design was conducted to study the pathological and clinical characteristics of 149 Ashkenazi Jewish EOBC patients (<42 years) who were referred consecutively to the oncogenetic clinic by the oncology centre at Rambam HealthCare Campus, as from 1995, with a mean follow-up of 13...
October 10, 2016: European Journal of Cancer Care
Preeti Sharma, Vijay Wadhwan, Pooja Aggarwal, Anamika Sharma
BACKGROUND: Oral verrucous hyperplasia (OVH) and oral verrucous carcinoma (OVC) are two distinct clinicopathologic verrucous lesions. However, the distinction between the two lesions still remains enigmatic. It is almost impossible to distinguish them clinically. Thus, the final diagnosis rests on the histopathological characteristics of both lesions, being distinguished from each other by an exophytic and endophytic growth pattern, respectively. METHODS: This institutional study was planned to review retrospectively two series of patients with histologic diagnoses of VH (n = 27) and VC (n = 27) to investigate their clinicopathological features and to analyze the role of immunohistochemical (IHC) marker p53 protein in distinguishing between the two verrucous lesions...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Ivan R Ilic, Nikola M Stojanović, Pavle J Randjelović, Marina N Mihajlović, Niko S Radulović, Ratko S Ilić
BACKGROUND: Invasive lobular breast cancer (ILC) is the second most frequent form of breast cancer. While cancer cells are regularly investigated, tumor stroma represents a highly unexplored field. AIMS: The aim of this study is to perform a detailed investigation of clinical, immunohistochemical, and morphometric characteristics of desmoplastic (D) and nondesmoplastic (ND) ILC. MATERIALS AND METHODS: This study included twenty cases of ILC that were divided into two groups designated as D and ND groups...
October 2016: Indian Journal of Pathology & Microbiology
Tamara Veiga-Parga, Krista M D La Perle, Shelley J Newman
Reproductive pathology of domestic guinea pigs is underreported to date. To provide a comprehensive review of uterine disease in guinea pigs, we performed a retrospective study of the pathology archives of the University of Tennessee, College of Veterinary Medicine. By histology, 13 of 37 uterine lesions in 23 animals were neoplastic; the other 24 nonneoplastic lesions included cystic endometrial hyperplasia (16 of 24), endometrial hemorrhage (3 of 24), pyometra (2 of 24), polyp (2 of 24), and mucometra (1 of 24)...
November 2016: Journal of Veterinary Diagnostic Investigation
Mohammed T Lilo, Derek Allison, Yuting Wang, MingHui Ao, Edward Gabrielson, Susan Geddes, Hui Zhang, Frederic Askin, Qing Kay Li
BACKGROUND: Fine-needle aspiration (FNA) biopsy of lung lesions is a highly accurate method for diagnosing and staging of lung cancers, particularly in patients with advanced cancer. Although, the majority of FNA cases of non-small cell lung carcinoma (NSCLC) can be subclassified by hematoxylin and eosin (H&E) sections, immunohistochemical (IHC) markers are usually necessary for difficult cases. Our previous study has shown that both P40 and P63 demonstrate differential sensitivity and specificity in the subclassification of squamous cell carcinoma (SqCC) using tumor tissue microarrays (TMA)...
May 2016: J Am Soc Cytopathol
Judit Moldvay, Katalin Fábián, Márta Jäckel, Zsuzsanna Németh, Krisztina Bogos, József Furák, László Tiszlavicz, János Fillinger, Balázs Döme, Zsuzsa Schaff
The aim of the study was to investigate the correlation between claudin (CLDN) protein expression and clinicopathological parameters as well as survival in histological subtypes of non-small cell lung cancer. Archived surgical resection specimens of 137 pathologic stage I primary bronchial cancers including 49 adenocarcinomas of non-lepidic variants (ADC), 46 adenocarcinomas of lepidic variants (L-ADC), and 42 squamous cell carcinomas (SCC) were examined. Immunohistochemistry (IHC) using antibodies against CLDN1,-2,-3,-4,-7 proteins as well as semiquantitative estimation (IHC scores 0-5) were performed...
September 29, 2016: Pathology Oncology Research: POR
Jennifer L Tackett, Avanté J Smack, Kathrin Herzhoff, Kathleen W Reardon, Stephanie Daoud, Isabela Granic
Recent efforts have demonstrated that thin-slice (TS) assessment-or assessment of individual characteristics after only brief exposure to that individual's behaviour-can produce reliable and valid measurements of child personality traits. The extent to which this approach can be generalized to archival data not designed to measure personality, and whether it can be used to measure personality pathology traits in youth, is not yet known. Archival video data of a parent-child interaction task was collected as part of a clinical intervention trial for aggressive children (N = 177)...
September 26, 2016: Personality and Mental Health
Margaret Cocks, Diana Taheri, Mark W Ball, Stephania M Bezerra, Maria Del Carmen Rodriguez, Bernardo F P Ricardo, Trinity J Bivalacqua, Rajni B Sharma, Alan Meeker, Alcides Chaux, Arthur L Burnett, George J Netto
Penile squamous cell carcinoma (SCC) is primarily treated by surgical resection. Locally advanced and metastatic disease require a multidisciplinary treatment approach. However, mortality and morbidity remain high and novel molecular and immunotherapeutic targets are actively being sought. We investigated the expression of immune checkpoint markers in penile cancers. Fifty-three invasive penile SCCs diagnosed between 1985 and 2013 were retrieved from our surgical pathology archives. Representative formalin-fixed, paraffin-embedded archival blocks were used for the construction of 2 high-density tissue microarrays (TMAs)...
September 20, 2016: Human Pathology
Yibing Ma, Zhiguo Jiang, Haopeng Zhang, Fengying Xie, Yushan Zheng, Huaqiang Shi, Yu Zhao
In the field of pathology, whole slide image (WSI) has become the major carrier of visual and diagnostic information. Content based image retrieval among WSIs can aid the diagnosis of an unknown pathological image by finding its similar regions in WSIs with diagnostic information. However, the huge size and complex content of WSI pose several challenges for retrieval. In this paper, we propose an unsupervised, accurate and fast retrieval method for breast histopathological image. Specifically, the method presents local statistical feature of nuclei for morphology and distribution of nuclei, and employs Gabor feature to describe texture information...
September 20, 2016: IEEE Journal of Biomedical and Health Informatics
Remi Hervochon, Antonio Bobbio, Claude Guinet, Audrey Mansuet-Lupo, Antoine Rabbat, Jean-François Régnard, Nicolas Roche, Diane Damotte, Antonio Iannelli, Marco Alifano
BACKGROUND: Hypothesizing that morphometric measurements are reliable markers of fitness in patients with lung cancer requiring aggressive surgical intervention, the purpose of this study was to assess their impact on postoperative outcome and long-term survival in patients with non-small cell lung cancer (NSCLC) requiring pneumonectomy. METHODS: Height, weight, and body mass index (BMI), as well as usual clinical, laboratory (including C-reactive protein [CRP] concentrations), and pathologic data were retrospectively retrieved from files of 161 consecutive patients treated by pneumonectomy for NSCLC, whose preoperative computed tomographic (CT) scans were available in the Picture Archive and Communication System (PACS) of the hospital...
September 19, 2016: Annals of Thoracic Surgery
Khaldon Bodoor, Sara Abu Jalboush, Ismail Matalka, Aya Abu-Sheikha, Rofieda Al Waq, Hanadi Ebwaini, Aymen Abu-Awad, Luma Fayyad, Jamal Al-Arjat, Yazan Haddad
Gastric cancer (GC) is a major health problem worldwide and is one of the ten most commonly diagnosed cancers in Jordan. GC is usually diagnosed at late aggressive stages in which treatment options are limited. Recently, heat shock proteins (HSPs) found to be overexpressed in a wide range of malignancies have been considered as promising candidate biomarkers for GC. The aim of this study was to investigate pathogenic roles of a panel of cytosolic HSPs including HSP90, HSP70, HSP60 and HSP27 in GC. Immunohistochemistry was used to assess the level of expression of these proteins in archived tumor samples (N=87) representing various pathological characteristics of GC...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Stefan Kommoss, C Blake Gilks, Andreas du Bois, Friedrich Kommoss
BACKGROUND: Until recently ovarian carcinoma was considered to be a single disease, and treatment decisions were based solely on grade and pre- and postoperative tumour burden. New insights into molecular features, treatment response, and patient demographics led the scientific community to conclude that ovarian carcinoma histotypes are different disease entities. METHODS: In 2002, the pathology specimens from patients in a clinical trial were reviewed by an experienced gynaecopathologist (pathologist A) for translational research purposes...
October 11, 2016: British Journal of Cancer
Daniele Regge, Simone Mazzetti, Valentina Giannini, Christian Bracco, Michele Stasi
Cancer is a complex disease and unfortunately understanding how the components of the cancer system work does not help understand the behavior of the system as a whole. In the words of the Greek philosopher Aristotle "the whole is greater than the sum of parts." To date, thanks to improved information technology infrastructures, it is possible to store data from each single cancer patient, including clinical data, medical images, laboratory tests, and pathological and genomic information. Indeed, medical archive storage constitutes approximately one-third of total global storage demand and a large part of the data are in the form of medical images...
September 13, 2016: La Radiologia Medica
Seth J Kligerman, Aaron Auerbach, Teri J Franks, Jeffrey R Galvin
Castleman disease is a complex lymphoproliferative disease pathologically divided into two subtypes, the hyaline vascular variant (HVV) and the plasma cell variant (PCV). The HVV is the most common, is thought to represent a benign neoplasm of lymph node stromal cells, and is treated with surgical resection. It is most commonly found in the mediastinum, where it classically appears as a unicentric, avidly enhancing mass at computed tomography (CT) and magnetic resonance imaging. This appearance can mimic other avidly enhancing mediastinal masses, and location, clinical history, laboratory data, and nuclear medicine single photon emission CT (SPECT) and positron emission tomography (PET) studies can help narrow the differential diagnosis...
September 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Wei Liang, Xuexun Zhou, Lan Yao, Baolin Liu
The preservation of DNA, RNA, and protein markers in biological specimens is essential for initial diagnosis, subsequent verification, and comparison, as well as for archival retention of pathological materials in modern molecular diagnostics and precision medicine. Considerable attention has been paid to the methods of collection, handling, and preparation of specimens for initial testing, but insufficient attention to the long-term specimen preservation for later verification, comparison, and archival retention...
September 12, 2016: Biopreservation and Biobanking
Syed Salahuddin Ahmed, Aye Aye Thike, Kathryn Zhang, Jeffrey Chun Tatt Lim, Puay Hoon Tan
AIMS: The presence of oestrogen and progesterone receptors (ER, PR) in breast carcinoma is an important prognostic indicator as well as a predictor of likely response to hormonal treatment. Current ambiguity surrounds ER-negative (-)/PR-positive (+) breast cancer (BC) as to whether this phenotype exists as a distinct entity. The independent predictive value of PR for treatment considerations is also in question, as some investigators believe ER status to be the single most important therapeutic predictive factor in BC...
September 9, 2016: Journal of Clinical Pathology
Ee Ming Wong, JiHoon E Joo, Catriona A McLean, Laura Baglietto, Dallas R English, Gianluca Severi, Hui-Chen Wu, Mary Beth Terry, John L Hopper, Roger L Milne, Graham G Giles, Melissa C Southey
PURPOSE: Aberrant DNA methylation occurs frequently in breast carcinogenesis. Tools for translational epigenetic studies of breast cancer involving formalin-fixed paraffin-embedded (FFPE) human tissues have now been developed. Few studies have measured genome-wide methylation in DNA derived from paraffin-embedded tumour tissues and compared the DNA methylation in corresponding adjacent non-tumour ductal epithelium (ADJNT). These studies are technically challenging due to the spectrum of breast cancer pathologies, the variable suitability of DNA extracted from FFPE material and the difficulties in identifying ADJNT...
November 2016: Breast Cancer Research and Treatment
P V Deepthi, V T Beena, S K Padmakumar, R Rajeev, R Sivakumar
CONTEXT: A study on odontogenic cysts and tumors. AIMS: The aim of this study is to determine the frequency of odontogenic cysts and tumors and their distribution according to age, gender, site and histopathologic types of those reported over a period of 1998-2012 in a Tertiary Health Care Center at South Kerala. SETTINGS AND DESIGN: The archives of Department of Oral Pathology and Microbiology, were retrospectively analyzed. SUBJECTS AND METHODS: Archival records were reviewed and all the cases of odontogenic cysts and tumors were retrieved from 1998 to 2012...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
C A Iyogun, O G Omitola, G E Ukegheson
AIM: A retrospective study of odontogenic tumors (OTs) in Port Harcourt was undertaken to establish its prevalence and compare with known data in the literature from Nigeria and elsewhere. MATERIALS AND METHODS: All pathologically diagnosed OTs between 2008 and 2013 at the archives of the Department of Oral Pathology and Oral Biology of the University of Port Harcourt/University of Port Harcourt Teaching Hospital were retrospectively studied and classified according to the 2005 WHO classification of OTs and allied diseases...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Rashmi Agarwal, Minal Chaudhary, Shruti Bohra, Shree Bajaj
OBJECTIVES: Natural killer (NK) cells are important effector lymphocytes. NK cells are considered to represent innate immune system. NK cells target and kill aberrant cells such as virally infected and tumorigenic cells. The purpose of this study was to assess the expression of CD57 in oral squamous cell carcinoma (OSCC) and to correlate the expression of CD57 with 3 years survival in patients with OSCC. MATERIALS AND METHODS: About 100 histopathologically diagnosed cases of OSCC of various grades were divided into two groups, i...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
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