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https://www.readbyqxmd.com/read/27920955/patma-parser-of-archival-tissue-microarray
#1
Lukasz Roszkowiak, Carlos Lopez
Tissue microarrays are commonly used in modern pathology for cancer tissue evaluation, as it is a very potent technique. Tissue microarray slides are often scanned to perform computer-aided histopathological analysis of the tissue cores. For processing the image, splitting the whole virtual slide into images of individual cores is required. The only way to distinguish cores corresponding to specimens in the tissue microarray is through their arrangement. Unfortunately, distinguishing the correct order of cores is not a trivial task as they are not labelled directly on the slide...
2016: PeerJ
https://www.readbyqxmd.com/read/27918745/simple-and-aneurysmal-bone-cyst-aspects-of-jaw-pseudocysts-based-on-an-experience-of-brazilian-pathology-service-during-53-years
#2
I Flores, M-E Hamilton, E-F Zanchin-Baldissera, A-C Uchoa-Vasconcelos, S-B Chaves-Tarquinio, A-P Neutzling-Gomes
BACKGROUND: Jaw pseudocysts are benign osseous lesions of unclear etiology. Among these, the simple bone cyst (SBC) and aneurysmal bone cyst (ABC) are intriguing bone pathologies still rarely studied together. This retrospective study aimed to present the long-term case series of patients with jaw pseudocysts focusing on the clinical, radiographic, and transoperative aspects. MATERIAL AND METHODS: A retrospective case series of patients with SBC and ABC was performed...
December 6, 2016: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/27900490/discordance-between-original-and-central-laboratories-in-er-and-her2-results-in-a-diverse-population-based-sample
#3
Jennifer J Griggs, Ann S Hamilton, Kendra L Schwartz, Weiqiang Zhao, Paul H Abrahamse, Dafydd G Thomas, Julie M Jorns, Rachel Jewell, Maria E Sibug Saber, Reina Haque, Steven J Katz
PURPOSE: To investigate the discordance between original and central laboratories in estrogen receptor (ER) status, in tumors originally deemed to be ER-negative, and in HER2 status in a diverse population-based sample. METHODS: In a follow-up study of 1785 women with Stage I-III breast cancer diagnosed between 2005 and 2007 in the Detroit and Los Angeles County SEER registry catchment areas, participants were asked to consent to reassessment of ER (in tumors originally deemed to be ER-negative) and HER2 status on archival tumor samples approximately four years after diagnosis...
November 29, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27899468/favorable-swallowing-outcomes-following-vagus-nerve-sacrifice-for-vagal-schwannoma-resection
#4
Mira A Patel, Danielle F Eytan, Justin Bishop, Joseph A Califano
OBJECTIVE: To determine the impact of unilateral vagal sacrifice for vagal schwannoma on postoperative swallowing function. STUDY DESIGN: Case series, chart review. SETTING: Academic medical institution. SUBJECTS AND METHODS: Ten patients underwent vagus nerve sacrifice for vagal schwannoma resection. Archived pathology records dating from 1985 through 2012 at our institution were retrospectively queried for cases of vagal schwannoma with vagus nerve sacrifice...
November 29, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27896667/head-and-neck-rhabdomyosarcoma-clinical-and-pathologic-characterization-of-seven-cases
#5
Eleanor Chen, Robert Ricciotti, Neal Futran, Dolphine Oda
Head and neck rhabdomyosarcoma occurs frequently in children and adolescents, and has been well studied in that population. In contrast, it is rare in adults and is not as well characterized clinically and pathologically. Seven cases of adult rhabdomyosarcoma occurring in head and neck were retrieved from the archives of Department of Pathology and Division of Oral Pathology at University of Washington. Radiologic findings and clinical history, as well as pathologic findings from hematoxylin and eosin slides and immunohistochemistry for myogenic markers were reviewed...
November 28, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27893841/seroprevalence-of-cutaneous-human-papillomaviruses-and-the-risk-of-external-genital-lesions-in-men-a-nested-case-control-study
#6
Shams Rahman, Dana E Rollison, Christine M Pierce Campbell, Tim Waterboer, Angelika Michel, Michael Pawlita, Luisa L Villa, Eduardo Lazcano Ponce, Wei Wang, Amy R Borenstein, Anna R Giuliano
BACKGROUND: A variety of cutaneous human papillomaviruses (HPV) are detectable in genital epithelial lesions in men and non-melanoma skin cancer patients. It remains unclear whether these viruses are associated causally with skin lesions. To date, no study has prospectively examined the association between cutaneous HPV seropositivity and development of external genital lesions (EGLs) in men. OBJECTIVES: To examine the association between seropositivity to cutaneous HPV types and the risk of subsequent development of EGLs...
2016: PloS One
https://www.readbyqxmd.com/read/27889754/serous-cystadenoma-of-the-pancreas-potentials-and-pitfalls-of-a-preoperative-cytopathologic-diagnosis
#7
Mohammed T Lilo, Christopher J VandenBussche, Derek B Allison, Anne Marie Lennon, Bouchra K Younes, Ralph H Hruban, Christopher L Wolfgang, Syed Z Ali
OBJECTIVES: Pancreatic serous cystadenomas (SCAs) are benign tumors. Technological advances in imaging have led to increased recognition of asymptomatic pancreatic cysts, consequently increasing the demand for cytomorphologic evaluations of cyst fluid. STUDY DESIGN: A retrospective search through the pathology archives over an 11-year period was performed to identify SCAs from pancreatectomy specimens with a presurgical pancreatic EUS-guided fine-needle aspiration (FNA)...
November 26, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27869105/an-open-access-database-for-the-evaluation-of-heart-sound-algorithms
#8
Chengyu Liu, David Springer, Qiao Li, Benjamin Moody, Ricardo Abad Juan, Francisco J Chorro, Francisco Castells, José Millet Roig, Ikaro Silva, Alistair E W Johnson, Zeeshan Syed, Samuel E Schmidt, Chrysa D Papadaniil, Leontios Hadjileontiadis, Hosein Naseri, Ali Moukadem, Alain Dieterlen, Christian Brandt, Hong Tang, Maryam Samieinasab, Mohammad Reza Samieinasab, Reza Sameni, Roger G Mark, Gari D Clifford
In the past few decades, analysis of heart sound signals (i.e. the phonocardiogram or PCG), especially for automated heart sound segmentation and classification, has been widely studied and has been reported to have the potential value to detect pathology accurately in clinical applications. However, comparative analyses of algorithms in the literature have been hindered by the lack of high-quality, rigorously validated, and standardized open databases of heart sound recordings. This paper describes a public heart sound database, assembled for an international competition, the PhysioNet/Computing in Cardiology (CinC) Challenge 2016...
November 21, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27858973/detection-and-genotyping-of-human-papillomaviruses-from-archival-formalin-fixed-tissue-samples
#9
Koenraad Van Doorslaer, Zigui Chen, Alison A McBride
Pathology departments routinely process and store formalin-fixed, paraffin-embedded (FFPE) tissue samples for clinical diagnosis. These collections often contain decades' worth of samples and represent a treasure trove of specimens that can be analyzed for retrospective epidemiological studies, diagnostics, and pathogen discovery. Accurate amplification and sequencing of DNA from these samples is critical for the usability of these FFPE samples. Here we present a collection of protocols that describe extraction of DNA from FFPE tissues, PCR amplification of human papillomavirus DNA, and subsequent genotyping of the infecting virus...
November 18, 2016: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/27837511/identification-of-fungal-pathogens-in-tissue-samples-from-patients-with-proven-invasive-infection-by-fluorescence-in-situ-hybridization
#10
Ilka McCormick Smith, Volker Rickerts
Identification of fungal pathogens in clinical samples by hybridization with short oligonucleotide probes is increasingly used in the diagnosis of invasive fungal infections. Rapid and specific fungal identification has been documented in different diagnostic settings allowing for specific patient management. Identification of fungal pathogens in formalin-fixed, paraffin-embedded tissue samples appears to be rewarding as these materials are stored in pathology archives offering an insight into the etiology of deep fungal infections that is often not achieved by non-molecular tests...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27826617/expression-and-function-of-pim-kinases-in-osteosarcoma
#11
Shuai Mou, Guangbin Wang, Ding Ding, Dongdong Yu, Yi Pei, Songling Teng, Qin Fu
The provirus integrating site Moloney murine leukemia virus (PIM) family of serine/threonine protein kinases is composed of three members, PIM1, PIM2 and PIM3, which have been identified as oncoproteins in various malignancies. However, their role in osteosarcoma (OS) remains largely unknown. This study aimed to examine the expression patterns and the clinical significance of PIM kinases in human OS and their biological effects in human OS cell lines. Immunohistochemical staining was used to detect PIM kinases in archived pathologic material from 43 patients with primary OS; in addition, the effects of PIM knockdown and overexpression on the proliferation, migration and invasion of OS cell lines were determined...
November 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27821183/does-preoperative-neutrophil-to-lymphocyte-or-platelet-to-lymphocyte-ratios-have-a-role-in-predicting-borderline-ovarian-tumors
#12
Ghanim Khatib, Cenk Soysal, Cihan Çetin, Ümran Küçükgöz Güleç, Ahmet Barış Güzel, Nadi Keskin, Mehmet Ali Vardar, Derya Gümürdülü
BACKGROUND: to investigate the value of using preoperative neutrophil to lymphocyte and platelet to lymphocyte levels in the patients of borderline ovarian tumors. METHODS: During the period between January 2002 and December 2015, the pathology reports and archival files of the Gynecologic Oncology Department of Çukurova University Medical Hospital and the Gynecologic Oncology Department of Dumlupınar University, Evliya Çelebi Education and Research Hospital were retrospectively reviewed, and 144 patients of borderline ovarian tumor (as the study group) and 123 patients of serous cystadenoma (as the control group) were determined for eligibility in this study...
November 8, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27817002/overexpression-of-aquaporin-1-is-a-prognostic-factor-for-biochemical-recurrence-in-prostate-adenocarcinoma
#13
Ji Y Park, GhilSuk Yoon
Aquaporins (AQP) are transmembrane proteins that provide channels for water and solutes, and some are involved in tumor progression and invasion. We evaluated the expression of AQP-1, AQP-3, and AQP-5 and their clinicopathological significance in prostate adenocarcinomas (PCA). Prostatectomy specimens (n = 99) were retrieved from the surgical pathology archives and clinicopathological data were obtained from the medical database at Kyungpook National University Hospital. Immunohistochemical staining for AQP-1, AQP-3, and AQP-5 was performed on tissue microarrays comprising paired malignant and benign prostatic tissues...
November 5, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27804009/a-new-method-for-the-automatic-retrieval-of-medical-cases-based-on-the-radlex-ontology
#14
A B Spanier, D Cohen, L Joskowicz
PURPOSE: The goal of medical case-based image retrieval (M-CBIR) is to assist radiologists in the clinical decision-making process by finding medical cases in large archives that most resemble a given case. Cases are described by radiology reports comprised of radiological images and textual information on the anatomy and pathology findings. The textual information, when available in standardized terminology, e.g., the RadLex ontology, and used in conjunction with the radiological images, provides a substantial advantage for M-CBIR systems...
November 1, 2016: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/27801735/fading-with-time-of-pd-l1-immunoreactivity-in-non-small-cells-lung-cancer-tissues-a-methodological-study
#15
Francesca Giunchi, Alessio Degiovanni, Niccolò Daddi, Rocco Trisolini, Andrea Dell'Amore, Claudio Agostinelli, Andrea Ardizzoni, Michelangelo Fiorentino
Blockade of inhibitory immune checkpoints is currently arising as a potential immunologic option for tumor therapy. Inhibition of programmed cell death protein 1 and/or its specific ligand programmed death-ligand 1 (PD-L1) was effective in clinical trials in advanced melanoma, non-small cell lung cancer (NSCLC) bladder and kidney cancer. The predictive role of the immunohistochemical (IHC) expression of PD-L1 is highly debated. Different reagents, clones, cutoffs of cell expression and subjective interpretation of PD-L1 immunoreactivity in epithelial cells and lymphocytes are the main issue...
October 31, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27797809/timing-and-significance-of-pathological-features-in-c9orf72-expansion-associated-frontotemporal-dementia
#16
Sarat C Vatsavayai, Soo Jin Yoon, Raquel C Gardner, Tania F Gendron, Jose Norberto S Vargas, Andrew Trujillo, Mochtar Pribadi, Joanna J Phillips, Stephanie E Gaus, John D Hixson, Paul A Garcia, Gil D Rabinovici, Giovanni Coppola, Daniel H Geschwind, Leonard Petrucelli, Bruce L Miller, William W Seeley
SEE SCABER AND TALBOT DOI101093/AWW264 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: A GGGGCC repeat expansion in C9orf72 leads to frontotemporal dementia and/or amyotrophic lateral sclerosis. Diverse pathological features have been identified, and their disease relevance remains much debated. Here, we describe two illuminating patients with frontotemporal dementia due to the C9orf72 repeat expansion. Case 1 was a 65-year-old female with behavioural variant frontotemporal dementia accompanied by focal degeneration in subgenual anterior cingulate cortex, amygdala, and medial pulvinar thalamus...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27797244/lack-of-evidence-for-a-relationship-between-high-risk-human-papillomaviruses-and-breast-cancer-in-iranian-patients
#17
Masoud Doosti, Mehran Bakhshesh, Shokouh Taghipour Zahir, Mohammad Shayestehpour, Mojgan Karimi-Zarchi
BACKGROUND: Whether there is any relationship between human papilloma virus (HPV) and breast carcinoma is not clear. Some previous studies have indicated a possible role in oncogenesis in the breast. In this study, we therefore analyzed the presence of HPV infection in breast tissues of Iranian women from Yazd city. MATERIALS AND METHODS: In a cross-sectional study, formalin-fixed paraffin-embedded tissues from 87 patients with breast cancer and 84 cases with breast fibrocystic lesions (control group) were selected from a tissue archive...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27796764/more-cases-of-benign-testicular-teratomas-are-detected-in-adults-than-in-children-a-clinicopathological-study-of-543-testicular-germ-cell-tumor-cases
#18
Semjén David, Farkas András, Kalman Endre, Kaszas Balint, Kovács Árpad, Pusztai Csaba, Szuhai Karoly, Tornóczky Tamás
Benign testicular teratomas are always thought to be pediatric neoplasms and previously all the teratoid tumors in the adult testis regarded as malignant. Recently, three publications reported benign testicular teratomas in adulthood and the latest WHO classification refers them as "prepubertal type of teratomas" which rarely appear in adulthood. These neoplasms behave benign and seemingly analogous independently whether they appear in pre- or postpubertal patients. The aim of our study was to investigate the frequency of benign testicular teratomas both in children and adults...
October 28, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27796180/evaluation-of-a-new-automated-microscopy-urine-sediment-analyser-sedimax-contrust%C3%A2
#19
Laura Bogaert, Bart Peeters, Jaak Billen
This study evaluated the performance of the stand-alone sediMAX conTRUST (77Elektronika, Budapest, Hungary) analyser as an alternative to microscopic analysis of urine. The validation included a precision, carry-over, categorical correlation and diagnostic performance study with manual phase-contrast microscopy as reference method. A total of 260 routine urine samples were assessed. The within-run precision was much better at higher concentrations than at very low concentrations. The precision met our predefined limits for all the elements at the different concentrations, with the exception of the lowest RBC, the WBC, pathological casts and crystals count...
October 31, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/27794402/the-prevalence-of-expression-of-mage-a3-and-prame-tumor-antigens-in-east-and-south-east-asian-non-small-cell-lung-cancer-patients
#20
Sumitra Thongprasert, Pan-Chyr Yang, Jung Shin Lee, Ross Soo, Olivier Gruselle, Aung Myo, Jamila Louahed, Frédéric F Lehmann, Vincent G Brichard, Thierry Coche
INTRODUCTION: Treatment of non-small cell lung cancer (NSCLC) is an important and often unmet medical need regardless of the disease stage at the time of first diagnosis. Antigen-specific immunotherapy may be a feasible therapeutic option if tumor associated antigens (TAAs) that can be targeted by the patient's immune system are identified. The study objective (NCT01837511) was to investigate the expression rates of MAGE-A3 and PRAME in tumors from East Asian NSCLC patients, and the associations between TAA expression and clinico-pathologic patient characteristics...
November 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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