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Buruli Ulcer

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https://www.readbyqxmd.com/read/29870529/laboratory-confirmation-of-buruli-ulcer-cases-in-ghana-2008-2016
#1
Dorothy Yeboah-Manu, Sammy Yaw Aboagye, Prince Asare, Adwoa Asante-Poku, Kobina Ampah, Emelia Danso, Evelyn Owusu-Mireku, Zuleihatu Nakobu, Edwin Ampadu
BACKGROUND: Buruli ulcer (BU), a necrotizing skin infection caused by Mycobacterium ulcerans is the third most important mycobacterial disease globally after tuberculosis and leprosy in immune competent individuals. This study reports on the retrospective analyses of microbiologically confirmed Buruli ulcer (BU) cases in seventy-five health facilities in Ghana. METHOD/PRINCIPAL FINDINGS: Pathological samples were collected from BU lesions and transported either through courier services or by car directly to the laboratory...
June 5, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29844323/naturally-occurring-a-loss-of-a-giant-plasmid-from-mycobacterium-ulcerans-subsp-shinshuense-makes-it-non-pathogenic
#2
Kazue Nakanaga, Yoshitoshi Ogura, Atsushi Toyoda, Mitsunori Yoshida, Hanako Fukano, Nagatoshi Fujiwara, Yuji Miyamoto, Noboru Nakata, Yuko Kazumi, Shinji Maeda, Tadasuke Ooka, Masamichi Goto, Kazunari Tanigawa, Satoshi Mitarai, Koichi Suzuki, Norihisa Ishii, Manabu Ato, Tetsuya Hayashi, Yoshihiko Hoshino
Mycobacterium ulcerans is the causative agent of Buruli ulcer (BU), a WHO-defined neglected tropical disease. All Japanese BU causative isolates have shown distinct differences from the prototype and are categorized as M. ulcerans subspecies shinshuense. During repeated sub-culture, we found that some M. shinshuense colonies were non-pigmented whereas others were pigmented. Whole genome sequence analysis revealed that non-pigmented colonies did not harbor a giant plasmid, which encodes elements needed for mycolactone toxin biosynthesis...
May 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29782522/molecular-detection-of-mycobacterium-ulcerans-in-the-environment-and-its-relationship-with-buruli-ulcer-occurrence-in-zio-and-yoto-districts-of-maritime-region-in-togo
#3
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Marcus Beissner, Kossi Badziklou, Ekanao Tedihou, Edith Nyaku, Komi Amekuse, Franz Xaver Wiedemann, Damintoti Simplice Karou, Gisela Bretzel
BACKGROUND: Buruli Ulcer (BU) is a neglected tropical skin infection caused by Mycobacterium ulcerans. Residence near aquatic areas has been identified as an important source of transmission of M. ulcerans with increased risk of contracting Buruli ulcer. However, the reservoir and the mode of transmission are not yet well known. The aim of this study was to identify the presence of M. ulcerans in the environment and its relationship with Buruli ulcer occurrence in Zio and Yoto districts of the maritime region in south Togo...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29771976/skin-disease-prevalence-study-in-schoolchildren-in-rural-c%C3%A3-te-d-ivoire-implications-for-integration-of-neglected-skin-diseases-skin-ntds
#4
Rie Roselyne Yotsu, Kouamé Kouadio, Bamba Vagamon, Konan N'guessan, Amari Jules Akpa, Aubin Yao, Julien Aké, Rigobert Abbet Abbet, Barbine Tchamba Agbor Agbor, Roger Bedimo, Norihisa Ishii, L Claire Fuller, Roderick Hay, Oriol Mitjà, Henning Drechsler, Kingsley Asiedu
BACKGROUND: Early detection of several skin-related neglected tropical diseases (skin NTDs)-including leprosy, Buruli ulcer, yaws, and scabies- may be achieved through school surveys, but such an approach has seldom been tested systematically on a large scale in endemic countries. Additionally, a better understanding of the spectrum of skin diseases and the at-risk populations to be encountered during such surveys is necessary to facilitate the process. METHODS: We performed a school skin survey for selected NTDs and the spectrum of skin diseases, among primary schoolchildren aged 5 to 15 in Côte d'Ivoire, West Africa...
May 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29712992/a-protocol-for-culturing-environmental-strains-of-the-buruli-ulcer-agent-mycobacterium-ulcerans
#5
Dezemon Zingue, Arup Panda, Michel Drancourt
Contaminations and fastidiousness of M. ulcerans may have both hamper isolation of strains from environmental sources. We aimed to optimize decontamination and culture of environmental samples to circumvent both limitations. Three strains of M. ulcerans cultured onto Middlebrook 7H10 at 30 °C for 20 days yielded a significantly higher number of colonies in micro-aerophilic atmosphere compared to ambient atmosphere, 5% CO2 and anaerobic atmosphere. In a second step, we observed that M. ulcerans genome uniquely encoded chitinase, fucosidase and A-D-GlcNAc-diphosphoryl polyprenol A-3-L-rhamnosyl transferase giving M...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29708969/microdeletion-on-chromosome-8p23-1-in-a-familial-form-of-severe-buruli-ulcer
#6
Quentin B Vincent, Aziz Belkadi, Cindy Fayard, Estelle Marion, Ambroise Adeye, Marie-Françoise Ardant, Christian R Johnson, Didier Agossadou, Lazaro Lorenzo, Julien Guergnon, Christine Bole-Feysot, Jeremy Manry, Patrick Nitschké, Ioannis Theodorou, Jean-Laurent Casanova, Laurent Marsollier, Annick Chauty, Laurent Abel, Alexandre Alcaïs
Buruli ulcer (BU), the third most frequent mycobacteriosis worldwide, is a neglected tropical disease caused by Mycobacterium ulcerans. We report the clinical description and extensive genetic analysis of a consanguineous family from Benin comprising two cases of unusually severe non-ulcerative BU. The index case was the most severe of over 2,000 BU cases treated at the Centre de Dépistage et de Traitement de la Lèpre et de l'Ulcère de Buruli, Pobe, Benin, since its opening in 2003. The infection spread to all limbs with PCR-confirmed skin, bone and joint infections...
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29642809/a-severe-case-of-em-mycobacterium-ulcerans-em-buruli-ulcer-osteomyelitis-requiring-a-below-knee-amputation
#7
Michael J Loftus, Nicola Kettleton-Butler, Denton Wade, R Michael Whitby, Paul Dr Johnson
No abstract text is available yet for this article.
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29642808/tackling-the-worsening-epidemic-of-buruli-ulcer-in-australia-in-an-information-void-time-for-an-urgent-scientific-response
#8
Daniel P O'Brien, Eugene Athan, Kim Blasdell, Paul De Barro
No abstract text is available yet for this article.
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29605498/delayed-versus-standard-assessment-for-excision-surgery-in-patients-with-buruli-ulcer-in-benin-a-randomised-controlled-trial
#9
Akpeedje C Wadagni, Yves T Barogui, Roch C Johnson, Ghislain E Sopoh, Dissou Affolabi, Tjip S van der Werf, Janine de Zeeuw, Johanneke Kleinnijenhuis, Ymkje Stienstra
BACKGROUND: Surgical intervention was once the mainstay of treatment for Buruli ulcer disease, a neglected tropical disease caused by Mycobacterium ulcerans. Since the introduction of streptomycin and rifampicin for 8 weeks as standard care, surgery has persisted as an adjunct therapy, but its role is uncertain. We investigated the effect of delaying the decision to operate to 14 weeks on rates of healing without surgery. METHODS: In this randomised controlled trial, we enrolled patients aged 3 years or older with confirmed disease at one hospital in Lalo, Benin...
June 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29605497/surgery-for-buruli-ulcer-in-the-antibiotic-era
#10
Paul D R Johnson
No abstract text is available yet for this article.
June 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29584724/developing-a-buruli-ulcer-community-of-practice-in-bankim-cameroon-a-model-for-buruli-ulcer-outreach-in-africa
#11
Paschal Kum Awah, Alphonse Um Boock, Ferdinand Mou, Joseph Tohnain Koin, Evaristus Mbah Anye, Djeunga Noumen, Mark Nichter
BACKGROUND: In the Cameroon, previous efforts to identify Buruli ulcer (BU) through the mobilization of community health workers (CHWs) yielded poor results. In this paper, we describe the successful creation of a BU community of practice (BUCOP) in Bankim, Cameroon composed of hospital staff, former patients, CHWs, and traditional healers. METHODS AND PRINCIPLE FINDINGS: All seven stages of a well-defined formative research process were conducted during three phases of research carried out by a team of social scientists working closely with Bankim hospital staff...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29554096/the-incubation-period-of-buruli-ulcer-mycobacterium-ulcerans-infection-in-victoria-australia-remains-similar-despite-changing-geographic-distribution-of-disease
#12
Michael J Loftus, Jason A Trubiano, Ee Laine Tay, Caroline J Lavender, Maria Globan, Janet A M Fyfe, Paul D R Johnson
BACKGROUND: Buruli ulcer (BU) is a geographically-restricted infection caused by Mycobacterium ulcerans; contact with an endemic region is the primary risk factor for disease acquisition. Globally, efforts to estimate the incubation period of BU are often hindered as most patients reside permanently in endemic areas. However, in the south-eastern Australian state of Victoria, a significant proportion of people who acquire BU are visitors to endemic regions. During a sustained outbreak of BU on the Bellarine peninsula we estimated a mean incubation period of 4...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29545962/subcutaneous-granulomatous-inflammation-due-to-basidiobolomycosis-case-reports-of-3-patients-in-buruli-ulcer-endemic-areas-in-benin
#13
Luc V C Brun, Jean Jacques Roux, Ghislain E Sopoh, Julia Aguiar, Miriam Eddyani, Wayne M Meyers, Dirk Stubbe, Marie T Akele Akpo, Françoise Portaels, Bouke C de Jong
Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for Basidiobolus ranarum and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29540678/inhibition-of-sec61-dependent-translocation-by-mycolactone-uncouples-the-integrated-stress-response-from-er-stress-driving-cytotoxicity-via-translational-activation-of-atf4
#14
Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, Jack Taunton, Anne E Willis, Ronald C Wek, Rachel E Simmonds
Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational translocation of proteins into the endoplasmic reticulum (ER). An outstanding question is the molecular pathway linking this to its known cytotoxicity. We have now used translational profiling to better understand the reprogramming that occurs in cells exposed to mycolactone. Gene ontology identified enrichment in genes involved in cellular response to stress, and apoptosis signalling among those showing enhanced translation...
March 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29538643/diagnostic-tests-for-buruli-ulcer-clinical-judgment-revisited
#15
Tjip S van der Werf
No abstract text is available yet for this article.
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29538642/diagnostic-accuracy-of-clinical-and-microbiological-signs-in-patients-with-skin-lesions-resembling-buruli-ulcer-in-an-endemic-region
#16
Miriam Eddyani, Ghislain E Sopoh, Gilbert Ayelo, Luc V C Brun, Jean-Jacques Roux, Yves Barogui, Dissou Affolabi, William R Faber, Marleen Boelaert, Annelies Van Rie, Françoise Portaels, Bouke C de Jong
Background: The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes increasingly important. We therefore aimed to determine the diagnostic accuracy of clinical signs and microbiological tests in patients presenting with lesions clinically compatible with BU...
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29529087/implementation-of-a-decentralized-community-based-treatment-program-to-improve-the-management-of-buruli-ulcer-in-the-ouinhi-district-of-benin-west-africa
#17
Arnaud Setondji Amoussouhoui, Ghislain Emmanuel Sopoh, Anita Carolle Wadagni, Roch Christian Johnson, Paulin Aoulou, Inès Elvire Agbo, Jean-Gabin Houezo, Micah Boyer, Mark Nichter
BACKGROUND: Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In Benin, BU patient care is being integrated into the government health system. In this paper, we report on an innovative pilot program designed to introduce BU decentralization in Ouinhi district, one of Benin's most endemic districts previously served by centralized hospital-based care...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29522516/report-of-a-series-of-82-cases-of-buruli-ulcer-from-nigeria-treated-in-benin-from-2006-to-2016
#18
Gilbert Adjimon Ayelo, Esai Anagonou, Anita Carolle Wadagni, Yves Thierry Barogui, Ange Dodji Dossou, Jean Gabin Houezo, Julia Aguiar, Roch Christian Johnson, Raoul Saizonou, Kingsley Asiedu, Ghislain Emmanuel Sopoh
BACKGROUND: Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29401455/membrane-perturbing-properties-of-toxin-mycolactone-from-mycobacterium-ulcerans
#19
Cesar A López, Clifford J Unkefer, Basil I Swanson, Jessica M J Swanson, S Gnanakaran
Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction with at least two molecular targets and the inhibition of protein uptake into the endoplasmic reticulum. Although it has been shown that the toxin can passively permeate into host cells, it is clearly lipophilic. Association with lipid carriers would have substantial implications for the toxin's distribution within a host organism, delivery to cellular targets, diagnostic susceptibility, and mechanisms of pathogenicity...
February 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29386234/practice-guidelines-for-clinical-microbiology-laboratories-mycobacteria
#20
REVIEW
Betty A Forbes, Geraldine S Hall, Melissa B Miller, Susan M Novak, Marie-Claire Rowlinson, Max Salfinger, Akos Somoskövi, David M Warshauer, Michael L Wilson
Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. In 2015, there were 174,608 new case of leprosy worldwide. India, Brazil, and Indonesia reported the most leprosy cases...
April 2018: Clinical Microbiology Reviews
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