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Buruli Ulcer

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https://www.readbyqxmd.com/read/29401455/membrane-perturbing-properties-of-toxin-mycolactone-from-mycobacterium-ulcerans
#1
Cesar A López, Clifford J Unkefer, Basil I Swanson, Jessica M J Swanson, S Gnanakaran
Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction with at least two molecular targets and the inhibition of protein uptake into the endoplasmic reticulum. Although it has been shown that the toxin can passively permeate into host cells, it is clearly lipophilic. Association with lipid carriers would have substantial implications for the toxin's distribution within a host organism, delivery to cellular targets, diagnostic susceptibility, and mechanisms of pathogenicity...
February 5, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29386234/practice-guidelines-for-clinical-microbiology-laboratories-mycobacteria
#2
REVIEW
Betty A Forbes, Geraldine S Hall, Melissa B Miller, Susan M Novak, Marie-Claire Rowlinson, Max Salfinger, Akos Somoskövi, David M Warshauer, Michael L Wilson
Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. In 2015, there were 174,608 new case of leprosy worldwide. India, Brazil, and Indonesia reported the most leprosy cases...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29372678/-a-papua-new-guinean-with-three-foot-ulcers
#3
A Coenders, M Verregghen, E P Baerends
A 25-year-old Papuan presented with three painless foot ulcers with undermined edges, induration and oedema. The appearance was typical for Buruli ulcer, which is caused by Mycobacterium ulcerans. A smear was positive for acid fast bacilli. Buruli ulcers are found in patients from humid and tropical regions and are treated with rifampicin and streptomycin during eight weeks.
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29361986/perceived-causes-and-risk-factors-of-buruli-ulcer-among-patients-at-agogo-presbyterian-hospital-in-ashanti-region-of-ghana
#4
Reindolf Anokye, Enoch Acheampong, Wisdom Kwadwo Mprah, Edward Sarpong
OBJECTIVE: The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Data was collected using a structured questionnaire and analysed using SPSS version 16...
January 23, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29351741/risk-factors-for-mycobacterium-ulcerans-infection-buruli-ulcer-in-togo-%C3%A2-a-case-control-study-in-zio-and-yoto-districts-of-the-maritime-region
#5
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Ebekalisai Piten, Marcus Beissner, Yiragnima Kobara, Komlan Kossi, Kossi Badziklou, Franz Xaver Wiedemann, Komi Amekuse, Gisela Bretzel, Damintoti Simplice Karou
BACKGROUND: Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation coverage. The objective of this study was to identify these risk factors in the districts of Zio and Yoto of the Maritime Region in Togo. METHODS: We conducted a case-control study in Zio and Yoto, two districts proved BU endemic from November 2014 to May 2015...
January 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29343539/buruli-ulcer-review-of-a-neglected-skin-mycobacterial-disease
#6
Jeannette Guarner
Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world with higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR in presumptive cases confirms the diagnosis. Medical treatment with oral rifampicin and intramuscular streptomycin or oral treatment with rifampicin plus clarithromycin for 8 weeks is supported by the World Health Organization...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29320578/the-potent-effect-of-mycolactone-on-lipid-membranes
#7
Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated...
January 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29289244/total-syntheses-of-mycolactone-a-b-and-its-analogues-for-the-exploration-of-the-biology-of-buruli-ulcer
#8
Sarah Saint-Auret, Anne-Caroline Chany, Virginie Casarotto, Cédric Tresse, Lise Parmentier, Hajer Abdelkafi, Nicolas Blanchard
Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.
December 1, 2017: Chimia
https://www.readbyqxmd.com/read/29237707/buruli-ulcer-a-prototype-for-ecosystem-related-infection-caused-by-mycobacterium-ulcerans
#9
REVIEW
Dezemon Zingue, Amar Bouam, Roger B D Tian, Michel Drancourt
Buruli ulcer is a noncontagious disabling cutaneous and subcutaneous mycobacteriosis reported by 33 countries in Africa, Asia, Oceania, and South America. The causative agent, Mycobacterium ulcerans , derives from Mycobacterium marinum by genomic reduction and acquisition of a plasmid-borne, nonribosomal cytotoxin mycolactone, the major virulence factor. M. ulcerans -specific sequences have been readily detected in aquatic environments in food chains involving small mammals. Skin contamination combined with any type of puncture, including insect bites, is the most plausible route of transmission, and skin temperature of <30°C significantly correlates with the topography of lesions...
January 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29181205/basidiobolomycosis-simulating-a-mycobacterium-ulcerans-infection-in-a-togolese-rural-child
#10
Bayaki Saka, Waguena Gnassingbe, Garba Mahamadou, Sefako Akakpo, Julienne Teclessou, Aurel Abilogun-Chokki, Abas Mouhari-Toure, Koussake Kombate, Palokinam Pitché
Background: Basidiobolomycosis is a deep mycosis which preferentially affects rural young people in tropical countries. We report an atypical case, with multiple ulcers, simulating a Buruli ulcer. Case Report: A 5-year-old boy, living in a rural area, was seen for ulcers on the buttocks and at the back and right flank that had been in progress for 4 months. On examination, we found an infiltrated plaque with sharp edges, little painful, located on the buttocks, back, and the right flank...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29155010/intra-amoebal-killing-of-mycobacterium-ulcerans-by-acanthamoeba-griffini-a-co-culture-model
#11
Amar Bouam, Eric Ghigo, Michel Drancourt
Mycobacterium ulcerans, a decaying Mycobacterium marinum derivative is responsible for Buruli ulcer, a notifiable non-contagious disabling infection highly prevalent in some West African countries. Aquatic environments are suspected to host M. ulcerans, however, the exact reservoirs remain unknown. While M. marinum was found to resist amoebal microbicidal activities, this remains unknown for M. ulcerans. In this study M. ulcerans was co-cultured with the moderately halophile Acanthamoeba griffini at 30 °C to probe this tropical amoeba as a potential reservoir for M...
November 17, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29148373/mycobacterium-ulcerans-dna-in-bandicoot-excreta-in-buruli-ulcer-endemic-area-northern-queensland-australia
#12
Katharina Röltgen, Gerd Pluschke, Paul D R Johnson, Janet Fyfe
To identify potential reservoirs/vectors of Mycobacterium ulcerans in northern Queensland, Australia, we analyzed environmental samples collected from the Daintree River catchment area, to which Buruli ulcer is endemic, and adjacent coastal lowlands by species-specific PCR. We detected M. ulcerans DNA in soil, mosquitoes, and excreta of bandicoots, which are small terrestrial marsupials.
December 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29137663/patent-landscape-of-neglected-tropical-diseases-an-analysis-of-worldwide-patent-families
#13
Folahanmi Tomiwa Akinsolu, Vitor Nobre de Paiva, Samuel Santos Souza, Orsolya Varga
BACKGROUND: "Neglected Tropical Diseases" (NTDs) affect millions of people in Africa, Asia and South America. The two primary ways of strategic interventions are "preventive chemotherapy and transmission control" (PCT), and "innovative and intensified disease management" (IDM). In the last 5 years, phenomenal progress has been achieved. However, it is crucial to intensify research effort into NTDs, because of the emerging drug resistance. According to the World Health Organization (WHO), the term NTDs covers 17 diseases, namely buruli ulcer, Chagas disease, dengue, dracunculiasis, echinococcosis, trematodiasis, human African trypanosomiasis, leishmaniasis, leprosy, lymphatic filariasis, onchocerciasis, rabies, schistosomiasis, soil-transmitted helminthes, taeniasis, trachoma, and yaws...
November 14, 2017: Globalization and Health
https://www.readbyqxmd.com/read/29057458/support-needs-of-people-living-with-mycobacterium-ulcerans-buruli-ulcer-disease-in-a-ghana-rural-community-a-grounded-theory-study
#14
Alex Effah, Steven J Ersser, Ann Hemingway
INTRODUCTION/BACKGROUND: Mycobacterium ulcerans (also known as Buruli ulcer) disease is a rare skin disease which is prevalent in rural communities in the tropics mostly in Africa. Mortality rate is low, yet morbidity and consequent disabilities affect the quality of life of sufferers. AIMS: The aim of this paper is to use the grounded theory method to explore the support needs of people living with the consequences of Buruli ulcer in an endemic rural community in Ghana...
October 23, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29046669/susceptibility-to-mycobacterium-ulcerans-disease-buruli-ulcer-is-associated-with-ifng-and-inos-gene-polymorphisms
#15
Stéphanie Bibert, Martin W Bratschi, Samuel Y Aboagye, Emilie Collinet, Nicole Scherr, Dorothy Yeboah-Manu, Christian Beuret, Gerd Pluschke, Pierre-Yves Bochud
Buruli ulcer (BU) is a chronic necrotizing disease of the skin and subcutaneous fat tissue. The causative agent, Mycobacterium ulcerans, produces mycolactone, a macrolide toxin, which causes apoptosis of mammalian cells. Only a small proportion of individuals exposed to M. ulcerans develop clinical disease, as surrounding macrophages may control the infection by bacterial killing at an early stage, while mycolactone concentration is still low. Otherwise, bacterial multiplication leads to in higher concentrations of mycolactone, with formation of necrotizing lesions that are no more accessible to immune cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28980523/increased-severity-and-spread-of-mycobacterium-ulcerans-southeastern-australia
#16
Alex Y C Tai, Eugene Athan, N Deborah Friedman, Andrew Hughes, Aaron Walton, Daniel P O'Brien
Reported cases of Mycobacterium ulcerans disease (Buruli ulcer) have been increasing in southeastern Australia and spreading into new geographic areas. We analyzed 426 cases of M. ulcerans disease during January 1998-May 2017 in the established disease-endemic region of the Bellarine Peninsula and the emerging endemic region of the Mornington Peninsula. A total of 20.4% of cases-patients had severe disease. Over time, there has been an increase in the number of cases managed per year and the proportion associated with severe disease...
January 15, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28957473/assessment-of-health-care-workers-knowledge-attitude-and-risk-perception-of-buruli-ulcer-disease-in-southern-nigeria
#17
Ngozi Ekeke, Anthony O Meka, Joseph N Chukwu, Charles C Nwafor, Chukwuka Alphonsus, Obinna K Mbah, Nelson O Madichie, Ufuoma Aduh, Matthew Ogbeifo, Bola O IseOluwa-Adelokiki, Joseph E Edochie, Joseph Ushaka, Kingsley N Ukwaja
Background: Poor knowledge of health care workers may be responsible for the under-diagnosis and low notification of Buruli ulcer (BU) in high-burden settings. This study assessed health care workers' knowledge, attitude and risk perception of BU in Southern Nigeria. Methods: We conducted a cross-sectional survey among 186 health care workers recruited from 58 health facilities in four states of Southern Nigeria. A semi-structured interviewer-administered questionnaire was administered to all participants...
May 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28932250/evidences-of-the-low-implication-of-mosquitoes-in-the-transmission-of-mycobacterium-ulcerans-the-causative-agent-of-buruli-ulcer
#18
REVIEW
Rousseau Djouaka, Francis Zeukeng, Jude Daiga Bigoga, David N'golo Coulibaly, Genevieve Tchigossou, Romaric Akoton, Sylla Aboubacar, Sodjinin Jean-Eudes Tchebe, Clavella Nantcho Nguepdjo, Razack Adeoti, Innocent Djegbe, Manuele Tamo, Wilfred Fon Mbacham, Solange E Kakou-Ngazoa, Anthony Ablordey
BACKGROUND: Buruli ulcer (BU) continues to be a serious public health threat in wet tropical regions and the mode of transmission of its etiological agent, Mycobacterium ulcerans (MU), remains poorly understood. In this study, mosquito species collected in endemic villages in Benin were screened for the presence of MU. In addition, the ability of mosquitoes larvae to pick up MU from their environment and remain colonized through the larval developmental stages to the adult stage was investigated...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28904608/the-chemistry-and-biology-of-mycolactones
#19
REVIEW
Matthias Gehringer, Karl-Heinz Altmann
Mycolactones are a group of macrolides excreted by the human pathogen Mycobacterium ulcerans, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of M. ulcerans, mycolactones are central to the pathogenesis of the neglected disease Buruli ulcer, a chronic and debilitating medical condition characterized by necrotic skin ulcers. Due to their complex structure and fascinating biology, mycolactones have inspired various total synthesis endeavors and structure-activity relationship studies...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28891259/mapping-biopsy-for-buruli-ulcer-self-medicated-with-occlusive-dressing
#20
Takuma Hayami, Toshifumi Takahashi, Takeshi Kato, Toshihiro Tanaka, Noriki Fujimoto
Buruli ulcer is the third most common mycobacterial infection next to tuberculosis and leprosy caused by Mycobacterium ulcerans. Although it affects the skin, subcutaneous tissues, muscles and sometimes bones, there is no reliable evidence to determine the extent of debridement. We present here a case of Buruli ulcer treated successfully with a preoperative mapping biopsy procedure, which had been self-medicated with occlusive dressing. Because Buruli ulcer is accompanied by subtle pain, patients and clinicians tend to initially treat the ulcer with occlusive dressing therapy, which leads to the misdiagnosis of Buruli ulcer as a common bacterial infection only judging from bacterial culture of the surface of the ulcer...
September 11, 2017: Journal of Dermatology
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