keyword
MENU ▼
Read by QxMD icon Read
search

Buruli Ulcer

keyword
https://www.readbyqxmd.com/read/28821017/the-location-of-australian-buruli-ulcer-lesions-implications-for-unravelling-disease-transmission
#1
Arvind Yerramilli, Ee Laine Tay, Andrew J Stewardson, Peter G Kelley, Emma Bishop, Grant A Jenkin, Mike Starr, Janine Trevillyan, Andrew Hughes, N Deborah Friedman, Daniel P O'Brien, Paul D R Johnson
BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is increasing in incidence in Victoria, Australia. To improve understanding of disease transmission, we aimed to map the location of BU lesions on the human body. METHODS: Using notification data and clinical records review, we conducted a retrospective observational study of patients diagnosed with BU in Victoria from 1998-2015. We created electronic density maps of lesion locations using spatial analysis software and compared lesion distribution by age, gender, presence of multiple lesions and month of infection...
August 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28783752/mycolactone-cytotoxicity-in-schwann-cells-could-explain-nerve-damage-in-buruli-ulcer
#2
Junichiro En, Sho Kitamoto, Akira Kawashima, Suguru Yonezawa, Yoshito Kishi, Norihisa Ishii, Masamichi Goto
Buruli ulcer is a chronic painless skin disease caused by Mycobacterium ulcerans. The local nerve damage induced by M. ulcerans invasion is similar to the nerve damage evoked by the injection of mycolactone in a Buruli ulcer mouse model. In order to elucidate the mechanism of this nerve damage, we tested and compared the cytotoxic effect of synthetic mycolactone A/B on cultured Schwann cells, fibroblasts and macrophages. Mycolactone induced much higher cell death and apoptosis in Schwann cell line SW10 than in fibroblast line L929...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28750103/bacterial-diversity-in-buruli-ulcer-skin-lesions-challenges-in-the-clinical-microbiome-analysis-of-a-skin-disease
#3
Chloé Van Leuvenhaege, Koen Vandelannoote, Dissou Affolabi, Françoise Portaels, Ghislain Sopoh, Bouke C de Jong, Miriam Eddyani, Conor J Meehan
BACKGROUND: Buruli ulcer (BU) is an infectious disease caused by Mycobacterium ulcerans and considered the third most prevalent mycobacterial disease in humans. Secondary bacterial infections in open BU lesions are the main cause of pain, delayed healing and systemic illness, resulting in prolonged hospital stay. Thus, understanding the diversity of bacteria, termed the microbiome, in these open lesions is important for proper treatment. However, adequately studying the human microbiome in a clinical setting can prove difficult when investigating a neglected tropical skin disease due to its rarity and the setting...
2017: PloS One
https://www.readbyqxmd.com/read/28749770/in-silico-prediction-of-antibiotic-resistance-in-mycobacterium-ulcerans-agy99-through-whole-genome-sequence-analysis
#4
Sushim Kumar Gupta, Michel Drancourt, Jean-Marc Rolain
Buruli ulcer is an emerging infectious disease caused by Mycobacterium ulcerans that has been reported from 33 countries. Antimicrobial agents either alone or in combination with surgery have been proved to be clinically relevant and therapeutic strategies have been deduced mainly from the empirical experience. The genome sequences of M. ulcerans strain AGY99, M. ulcerans ecovar liflandii, and three Mycobacterium marinum strains were analyzed to predict resistance in these bacteria. Fourteen putative antibiotic resistance genes from different antibiotics classes were predicted in M...
July 24, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28733024/ecohealth-research-in-africa-where-from-where-to
#5
EDITORIAL
Robert Bergquist, Norbert W Brattig, Moses J Chimbari, Jakob Zinsstag, Jürg Utzinger
Epidemiological mapping and risk profiling build on the idea that diseases are tied to social-ecological systems that govern the distribution and abundance of transmissible pathogens, vectors and hosts. This is the heart of the emerging field of ecohealth, which examines how biological, cultural, demographic, economic, physical, political and social environments change can affect the health and wellbeing of humans, animals and ecosystems and the services they provide. This paper is an overview of a special issue of Acta Tropica, whose 15 publications reflect a geographically and epidemiologically diverse landscape of ecohealth in Africa...
July 18, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28718822/a-bacterial-toxin-with-analgesic-properties-hyperpolarization-of-drg-neurons-by-mycolactone
#6
Ok-Ryul Song, Han-Byul Kim, Samuel Jouny, Isabelle Ricard, Alexandre Vandeputte, Nathalie Deboosere, Estelle Marion, Christophe J Queval, Pierre Lesport, Emmanuel Bourinet, Daniel Henrion, Seog Bae Oh, Guillaume Lebon, Guillaume Sandoz, Edouard Yeramian, Laurent Marsollier, Priscille Brodin
Mycolactone, a polyketide molecule produced by Mycobacterium ulcerans, is the etiological agent of Buruli ulcer. This lipid toxin is endowed with pleiotropic effects, presents cytotoxic effects at high doses, and notably plays a pivotal role in host response upon colonization by the bacillus. Most remarkably, mycolactone displays intriguing analgesic capabilities: the toxin suppresses or alleviates the pain of the skin lesions it inflicts. We demonstrated that the analgesic capability of mycolactone was not attributable to nerve damage, but instead resulted from the triggering of a cellular pathway targeting AT₂ receptors (angiotensin II type 2 receptors; AT₂R), and leading to potassium-dependent hyperpolarization...
July 18, 2017: Toxins
https://www.readbyqxmd.com/read/28671942/clearance-of-viable-mycobacterium-ulcerans-from-buruli-ulcer-lesions-during-antibiotic-treatment-as-determined-by-combined-16s-rrna-reverse-transcriptase-is-2404-qpcr-assay
#7
Mabel Sarpong-Duah, Michael Frimpong, Marcus Beissner, Malkin Saar, Ken Laing, Francisca Sarpong, Aloysius Dzigbordi Loglo, Kabiru Mohammed Abass, Margaret Frempong, Fred Stephen Sarfo, Gisela Bretzel, Mark Wansbrough-Jones, Richard Odame Phillips
INTRODUCTION: Buruli ulcer (BU) caused by Mycobacterium ulcerans is effectively treated with rifampicin and streptomycin for 8 weeks but some lesions take several months to heal. We have shown previously that some slowly healing lesions contain mycolactone suggesting continuing infection after antibiotic therapy. Now we have determined how rapidly combined M. ulcerans 16S rRNA reverse transcriptase / IS2404 qPCR assay (16S rRNA) became negative during antibiotic treatment and investigated its influence on healing...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28500810/environmental-and-behavioral-drivers-of-buruli-ulcer-disease-in-selected-communities-along-the-densu-river-basin-of-ghana-a-case-control-study
#8
Samuel Yaw Aboagye, Prince Asare, Isaac Darko Otchere, Eric Koka, George Ekow Mensah, Dzidzo Yirenya-Tawiah, Dorothy Yeboah-Manu
AbstractThe exact route of transmission of Mycobacterium ulcerans (MU) (causative agent of Buruli ulcer [BU]), risk factors, and reservoir hosts are not clearly known, although it has been identified as an environmental pathogen. This study assessed potential environmental and behavioral risk factors that influence BU infections. We conducted a case-control study where cases were matched by their demographic characteristics and place of residence. A structured questionnaire was administered to solicit information on the environmental and behavioral factors of participants that may expose them to infection...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28487559/global-and-local-environmental-changes-as-drivers-of-buruli-ulcer-emergence
#9
Marine Combe, Camilla Jensen Velvin, Aaron Morris, Andres Garchitorena, Kevin Carolan, Daniel Sanhueza, Benjamin Roche, Pierre Couppié, Jean-François Guégan, Rodolphe Elie Gozlan
No abstract text is available yet for this article.
May 10, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28481900/yaws-resurgence-in-bankim-cameroon-the-relative-effectiveness-of-different-means-of-detection-in-rural-communities
#10
Alphonse Um Boock, Paschal Kum Awah, Ferdinand Mou, Mark Nichter
BACKGROUND: Yaws is an infectious, debilitating and disfiguring disease of poverty that mainly affects children in rural communities in tropical areas. In Cameroon, mass-treatment campaigns carried out in the 1950s reduced yaws to such low levels that it was presumed the disease was eradicated. In 2010, an epidemiological study in Bankim Health District detected 29 cases of yaws. Five different means of detecting yaws in clinical and community settings were initiated in Bankim over the following five years...
May 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28450515/draft-genome-sequence-of-mycobacterium-ulcerans-s4018-isolated-from-a-patient-with-an-active-buruli-ulcer-in-benin-africa
#11
Stanimir Kambarev, Stéphane Corvec, Annick Chauty, Estelle Marion, Laurent Marsollier, Frédéric Pecorari
Currently, there are only two publicly available genomes of Mycobacterium ulcerans-the causative agent of the neglected, but devastating, tropical disease Buruli ulcer. Here, we report the draft genome sequence of isolate S4018, recovered from an active cutaneous lesion of a patient with Buruli ulcer in Benin, Africa.
April 27, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28442755/global-and-local-environmental-changes-as-drivers-of-buruli-ulcer-emergence
#12
REVIEW
Marine Combe, Camilla Jensen Velvin, Aaron Morris, Andres Garchitorena, Kevin Carolan, Daniel Sanhueza, Benjamin Roche, Pierre Couppié, Jean-François Guégan, Rodolphe Elie Gozlan
Many emerging infectious diseases are caused by generalist pathogens that infect and transmit via multiple host species with multiple dissemination routes, thus confounding the understanding of pathogen transmission pathways from wildlife reservoirs to humans. The emergence of these pathogens in human populations has frequently been associated with global changes, such as socio-economic, climate or biodiversity modifications, by allowing generalist pathogens to invade and persist in new ecological niches, infect new host species, and thus change the nature of transmission pathways...
April 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28442219/virulence-potential-of-staphylococcus-aureus-isolates-from-buruli-ulcer-patients
#13
Nana Ama Amissah, Monika A Chlebowicz, Anthony Ablordey, Caitlin S Tetteh, Isaac Prah, Tjip S van der Werf, Alex W Friedrich, Jan Maarten van Dijl, Ymkje Stienstra, John W Rossen
Buruli ulcer (BU) is a necrotizing infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans. BU wounds may also be colonized with other microorganisms including Staphylococcus aureus. This study aimed to characterize the virulence factors of S. aureus isolated from BU patients. Previously sequenced genomes of 21 S. aureus isolates from BU patients were screened for the presence of virulence genes. The results show that all S. aureus isolates harbored on their core genomes genes for known virulence factors like α-hemolysin, and the α- and β-phenol soluble modulins...
June 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28438917/disease-ecology-health-and-the-environment-a-framework-to-account-for-ecological-and-socio-economic-drivers-in-the-control-of-neglected-tropical-diseases
#14
A Garchitorena, S H Sokolow, B Roche, C N Ngonghala, M Jocque, A Lund, M Barry, E A Mordecai, G C Daily, J H Jones, J R Andrews, E Bendavid, S P Luby, A D LaBeaud, K Seetah, J F Guégan, M H Bonds, G A De Leo
Reducing the burden of neglected tropical diseases (NTDs) is one of the key strategic targets advanced by the Sustainable Development Goals. Despite the unprecedented effort deployed for NTD elimination in the past decade, their control, mainly through drug administration, remains particularly challenging: persistent poverty and repeated exposure to pathogens embedded in the environment limit the efficacy of strategies focused exclusively on human treatment or medical care. Here, we present a simple modelling framework to illustrate the relative role of ecological and socio-economic drivers of environmentally transmitted parasites and pathogens...
June 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28437439/landscape-and-environmental-influences-on-mycobacterium-ulcerans-distribution-among-aquatic-sites-in-ghana
#15
Shannon M Pileggi, Heather Jordan, Julie A Clennon, Ellen Whitney, M Eric Benbow, Richard Merritt, Mollie McIntosh, Ryan Kimbirauskas, Pamela Small, Daniel Boakye, Charles Quaye, Jiaguo Qi, Lindsay Campbell, Jenni Gronseth, Edwin Ampadu, William Opare, Lance A Waller
Buruli ulcer, caused by Mycobacterium ulcerans, is highly endemic in West Africa. While the mode of transmission is unknown, many studies associate Buruli ulcer with different types of water exposure. We present results from the largest study to date to test for M. ulcerans in aquatic sites and identify environmental attributes associated with its presence. Environmental samples from 98 aquatic sites in the Greater Accra, Ashanti, and Volta regions of Ghana were tested for the presence of M. ulcerans DNA by polymerase chain reaction...
2017: PloS One
https://www.readbyqxmd.com/read/28418294/exposure-risk-for-infection-and-lack-of-human-to-human-transmission-of-mycobacterium-ulcerans-disease-australia
#16
Daniel P O'Brien, James W Wynne, Andrew H Buultjens, Wojtek P Michalski, Timothy P Stinear, N Deborah Friedman, Andrew Hughes, Eugene Athan
We conducted epidemiologic and genetic analyses of family clusters of Mycobacterium ulcerans (Buruli ulcer) disease in southeastern Australia. We found that the incidence of M. ulcerans disease in family members was increased. However, the risk for exposure appeared short-term and not related to human-human transmission.
May 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28410412/mycobacterium-ulcerans-low-infectious-dose-and-mechanical-transmission-support-insect-bites-and-puncturing-injuries-in-the-spread-of-buruli-ulcer
#17
John R Wallace, Kirstie M Mangas, Jessica L Porter, Renee Marcsisin, Sacha J Pidot, Brian Howden, Till F Omansen, Weiguang Zeng, Jason K Axford, Paul D R Johnson, Timothy P Stinear
Addressing the transmission enigma of the neglected disease Buruli ulcer (BU) is a World Health Organization priority. In Australia, we have observed an association between mosquitoes harboring the causative agent, Mycobacterium ulcerans, and BU. Here we tested a contaminated skin model of BU transmission by dipping the tails from healthy mice in cultures of the causative agent, Mycobacterium ulcerans. Tails were exposed to mosquito (Aedes notoscriptus and Aedes aegypti) blood feeding or punctured with sterile needles...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28392809/in-vitro-susceptibility-of-mycobacterium-ulcerans-isolates-to-selected-antimicrobials
#18
Enid Owusu, Mercy J Newman, Kwesi K Addo, Phyllis Addo
Background. The current definitive treatment of Buruli ulcer with antibiotics makes the issue of antimicrobial drug resistance an unavoidable one. This is as a result of drug misuse by health personnel and patients' noncompliance to treatment regimen. Monitoring of these factors and screening for new effective antimicrobials are crucial to effective management of Buruli ulcer disease. This study therefore investigated the inhibitory activity of some antibiotics against isolates of Mycobacterium ulcerans. Methods...
2017: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/28392785/an-optimized-method-for-extracting-bacterial-rna-from-mouse-skin-tissue-colonized-by-mycobacterium-ulcerans
#19
Marie Robbe-Saule, Jérémie Babonneau, Odile Sismeiro, Laurent Marsollier, Estelle Marion
Bacterial transcriptome analyses during host colonization are essential to decipher the complexity of the relationship between the bacterium and its host. RNA sequencing (RNA-seq) is a promising approach providing valuable information about bacterial adaptation, the host response and, in some cases, mutual tolerance underlying crosstalk, as recently observed in the context of Mycobacterium ulcerans infection. Buruli ulcer is caused by M. ulcerans. This neglected disease is the third most common mycobacterial disease worldwide...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28344056/chronic-cutaneous-mycobacterial-ulcers-due-to-mycobacterium-ulcerans-buruli-ulcer-the-first-indigenous-case-report-from-jordan-and-a-literature-review
#20
Jamal Wadi Al Ramahi, Hassan Annab, Mutaz Al Karmi, Basel Kirresh, Mahmoud Wreikat, Rami Batarseh, Muhannad Yacoub, Mais Kaderi
BACKGROUND: Buruli ulcer is the third most common mycobacterial infection worldwide. It is endemic in tropical, subtropical, and temperate climates. It causes devastating disease with morbidity and mortality. The treatment duration is long and the regimens considered are limited. Chronic cutaneous ulcers of mycobacterial etiology have been reported previously in Amman, but these were not associated with Mycobacterium ulcerans infection. METHODS: The case patient's initial diagnosis was based on chronological and morphological features, combined with appropriate diagnostic tests...
May 2017: International Journal of Infectious Diseases: IJID
keyword
keyword
112259
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"