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Buruli Ulcer

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https://www.readbyqxmd.com/read/28095422/high-throughput-carbon-substrate-profiling-of-mycobacterium-ulcerans-suggests-potential-environmental-reservoirs
#1
Dezemon Zingue, Amar Bouam, Muriel Militello, Michel Drancourt
BACKGROUND: Mycobacterium ulcerans is a close derivative of Mycobacterium marinum and the agent of Buruli ulcer in some tropical countries. Epidemiological and environmental studies pointed towards stagnant water ecosystems as potential sources of M. ulcerans, yet the ultimate reservoirs remain elusive. We hypothesized that carbon substrate determination may help elucidating the spectrum of potential reservoirs. METHODOLOGY/PRINCIPAL FINDINGS: In a first step, high-throughput phenotype microarray Biolog was used to profile carbon substrates in one M...
January 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28073729/phytotherapy-against-buruli-ulcer-in-the-health-district-of-yamoussoukro-cote-d-ivoire-%C3%A2-identification-description-and-symbolic-functions-of-the-plants-and-recipes-used
#2
A A Adjet, D Kouame, G Fokou
This study aims to describe the plants and recipes proposed by traditional healers against Buruli ulcer in Côte d'Ivoire and to analyze their symbolic aspects. Buruli ulcer is an increasingly serious health problem in Côte d'Ivoire. The ivorian state through the National Buruli Ulcer Control Programme and its partners, has developed various actions to fight that disease. Medical and surgical treatments are offered free of charge to patients. Hundreds of health centers in different health districts have been converted into Buruli ulcer management centers...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28061905/epidemiology-of-mansonella-perstans-in-the-middle-belt-of-ghana
#3
Linda Batsa Debrah, Norman Nausch, Vera Serwaa Opoku, Wellington Owusu, Yusif Mubarik, Daniel Antwi Berko, Samuel Wanji, Laura E Layland, Achim Hoerauf, Marc Jacobsen, Alexander Yaw Debrah, Richard O Phillips
BACKGROUND: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28056807/evaluating-decontamination-protocols-for-the-isolation-of-mycobacterium-ulcerans-from-swabs
#4
Enid Owusu, Mercy J Newman, Amos Akumwena, Elizabeth Bannerman, Gerd Pluschke
BACKGROUND: Mycobacterium ulcerans (M. ulcerans) is the causative agent of Buruli Ulcer (BU) disease. In order to inhibit the growth of the microbial contaminants during culture of M. ulcerans, it is necessary to decontaminate BU samples with effective chemical agents. This study aimed at investigating some selected chemicals as potential decontamination agents for the isolation of M. ulcerans from swabs. RESULTS: Povidone iodine at 0.5 and 1% exhibited the lowest contamination and recovery rate for microbial contaminants and M...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28043557/antimycobacterial-potency-and-cytotoxicity-study-of-three-medicinal-plants
#5
Patrick Valere Tsouh Fokou, Regina Appiah-Opong, Dorothy Yeboah-Manu, Abena Adomah Kissi-Twum, Lauve Rachel Tchokouaha Yamthe, Aristide Laurel Mokale Kognou, Phyllis Addo, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
OBJECTIVE/BACKGROUND: Mycobacterial infections including tuberculosis, leprosy, and buruli ulcer are among the most prevalent, debilitating, and deadly tropical diseases, especially in Sub-Saharan Africa. The development of drug resistance to the currently available drugs and the poor compliance emphasize the need for new chemotherapeutic agents. This study was designed to evaluate the in vitro activity of Cleistopholis patens, Annona reticulata, and Greenwayodendron suaveolens against Mycobacterium smegmatis...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043556/antimycobacterial-ingredients-from-plants-used-in-traditional-medicine-to-treat-buruli-ulcer
#6
Patrick Valere Tsouh Fokou, Abena Adomah Kissi-Twum, Dorothy Yeboah-Manu, Regina Appiah-Opong, Phyllis Addo, Lauve Rachel Tchokouaha Yamthe, Alvine Ngoutane Mfopa, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
AIM AND OBJECTIVES: Buruli ulcer (BU) is a neglected tropical disease caused by a mycobacteria, Mycobacterium ulcerans. The WHO recommended Rifampicin-Streptomycin combination side effects and poor compliance, leaves rural populations with no choice than to patronise indigenous remedies. This study is aimed at validating medicinal plants used in traditional medicine to treat BU by investigating the in vitro efficacy and safety as well as their composition in active molecules. METHODS: A short report-based survey was used to identify medicinal plants used traditionally for BU treatment...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28043490/antimycobacterial-activity-of-medicinal-plants-against-the-causative-agent-of-buruli-ulcer-mycobacterium-ulcerans
#7
R Keumoe, M S Nguembou, F P V Tsouh, D V F Donkeng, D Dize, Y L R Tchokouaha, M C D Jiatsa, F R D Youmsi, B Ngameni, B F Fekam
OBJECTIVE/BACKGROUND: Buruli ulcer, known as necrotizing skin disease caused by Mycobacterium ulcerans, has emerged as the most prevalent mycobacteriosis after leprosy and tuberculosis. Accordingly, it has been classified by the World Health Organization as a neglected disease with high significance in tropical areas, including Cameroon. So far, the control of the disease relies mainly on the rifampin-streptomycin combination. Despite its efficiency, it has shown considerable issues, including availability and side effects...
December 2016: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28034768/characteristics-and-epidemiological-profile-of-buruli-ulcer-in-the-district-of-tiassal%C3%A3-south-c%C3%A3-te-d-ivoire
#8
Raymond R T A S N'krumah, Brama Koné, Guéladio Cissé, Marcel Tanner, Jürg Utzinger, Gerd Pluschke, Issaka Tiembré
Buruli ulcer (BU) is a cutaneous infectious disease caused by Mycobacterium ulcerans. It is the third most common mycobacterial disease in the world in the immunocompetent patient and second in Côte d'Ivoire after tuberculosis. This study aimed to assess the characteristics and epidemiological profile of BU in the district of Tiassalé, an important focus of the disease in south Côte d'Ivoire, in order to better direct actions for prevention and control. Retrospective clinical data of BU cases in the period 2005-2010 from all 19 district health centres were collected and linked with geographical and environmental survey data...
December 26, 2016: Acta Tropica
https://www.readbyqxmd.com/read/28033343/former-buruli-ulcer-patients-experiences-and-wishes-may-serve-as-a-guide-to-further-improve-buruli-ulcer-management
#9
Anita Velink, Rebecca J Woolley, Richard O Phillips, Kabiru M Abass, Tjip S van der Werf, Emmanuel Agumah, Janine de Zeeuw, Sandor Klis, Ymkje Stienstra
BACKGROUND: Buruli ulcer (BU), caused by Mycobacterium ulcerans, is a neglected tropical disease frequently leading to permanent disabilities. The ulcers are treated with rifampicin and streptomycin, wound care and, if necessary surgical intervention. Professionals have exclusively shaped the research agenda concerning management and control, while patients' perspective on priorities and preferences have not explicitly been explored or addressed. METHODOLOGY/PRINCIPAL FINDINGS: To get insight into patient perception of the management and control of Buruli ulcer a mixed methods research design was applied with a questionnaire and focus group discussions among former BU patients...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28001222/secondary-bacterial-isolates-from-previously-untreated-buruli-ulcer-lesions-and-their-antibiotic-susceptibility-patterns-in-southern-nigeria
#10
Moses Chibueze Anyim, Anthony Obiamaka Meka, Joseph Ngozi Chukwu, Charles Chukwunalu Nwafor, Daniel Chukwunweolu Oshi, Nelson Okechukwu Madichie, Ngozi Ekeke, Chukwuka Alphonsus, Obinna Mbah, Chinenye Nwaekpe, Martin Njoku, Dare Fakiyesi, Vitalis Ulodiaku, Ignatius Ejiofor, Adeniyi Hakeem Bisiriyu, Kingsley Nnanna Ukwaja
INTRODUCTION: Mycolactones, secreted by Mycobacterium ulcerans, were previously believed to prevent super infection in Buruli ulcer lesions. However, little is known about secondary bacterial infections in these lesions. This study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated Buruli ulcer disease from three states in Southern Nigeria. METHODS: A prospective analysis was conducted between January and June of 2015 using wound swabs from eligible patients with Buruli ulcer disease, confirmed by quantitative-polymerase chain reaction, with active ulcers...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27986841/financial-burden-of-health-care-for-buruli-ulcer-patients-in-nigeria-the-patients-perspective
#11
Joseph N Chukwu, Anthony O Meka, Charles C Nwafor, Daniel C Oshi, Nelson O Madichie, Ngozi Ekeke, Moses C Anyim, Alphonsus Chukwuka, Mbah Obinna, Julie Adegbesan, Martin Njoku, Festus O Soyinka, Adebola O Adelokiki, Isreal O Enemuoh, Patrick I Okolie, Joseph E Edochie, Jonah B Offor, Joseph Ushaka, Kingsley N Ukwaja
BACKGROUND: The economic burden of Buruli ulcer for patients has not been well-documented. This study assessed the costs of Buruli ulcer care to patients from the onset of illness to diagnosis and to the end of treatment. METHODS: This was a cross-sectional cost of illness study conducted among patients with Buruli ulcer in four States in Nigeria between July and September 2015. A structured questionnaire was used to collect data on the patients' characteristics, household income and out-of-pocket costs of care...
January 2017: International Health
https://www.readbyqxmd.com/read/27941982/overexpression-of-a-mycobacterium-ulcerans-ag85b-esxh-fusion-protein-in-recombinant-bcg-improves-experimental-buruli-ulcer-vaccine-efficacy
#12
Bryan E Hart, Sunhee Lee
Buruli ulcer (BU) vaccine design faces similar challenges to those observed during development of prophylactic tuberculosis treatments. Multiple BU vaccine candidates, based upon Mycobacterium bovis BCG, altered Mycobacterium ulcerans (MU) cells, recombinant MU DNA, or MU protein prime-boosts, have shown promise by conferring transient protection to mice against the pathology of MU challenge. Recently, we have shown that a recombinant BCG vaccine expressing MU-Ag85A (BCG MU-Ag85A) displayed the highest level of protection to date, by significantly extending the survival time of MU challenged mice compared to BCG vaccination alone...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27907248/mycobacterium-ulcerans-toxin-mycolactone-may-enhance-host-seeking-and-oviposition-behavior-by-aedes-aegypti-l-diptera-culicidae
#13
M L Sanders, H R Jordan, C Serewis-Pond, L Zheng, M E Benbow, P L Small, J K Tomberlin
The ecological functions of many toxins continue to remain unknown for those produced by environmental pathogens. Mycobacterium ulcerans, the causative agent of the neglected tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive. Through a series of dual-choice behavior assays, we show that mycolactone may be an interkingdom cue for the yellow fever mosquito, Aedes aegypti, seeking blood-meals as well as oviposition sites. Results provide novel insight into the evolution between bacteria and potential vectors...
December 1, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27893778/mycobacterium-ulcerans-mouse-model-refinement-for-pre-clinical-profiling-of-vaccine-candidates
#14
Angèle Bénard, Claudia Sala, Gerd Pluschke
Buruli Ulcer is a neglected tropical disease leading to extensive disabilities and morbidity in West Africa. In this paper we sought to characterize various strains of Mycobacterium ulcerans (M.ulcerans) with different origins and laboratory passage records while refining a mouse model for Buruli ulcer. We described, compared and followed the kinetics of the histo-pathological outcome of infection of a collection of strains at various anatomical sites of infection in order to find a suitable model for further immunization studies...
2016: PloS One
https://www.readbyqxmd.com/read/27804194/mycobacterium-ulcerans-in-the-daintree-2009-2015-and-the-mini-epidemic-of-2011
#15
Christina M Steffen, Helen Freeborn
BACKGROUND: Mycobacterium ulcerans infection (Buruli ulcer) is the third most common mycobacterial disease in humans, with presentations ranging from self-limiting skin nodules and ulcers to aggressive infiltrative infections with extensive oedema, fat and skin necrosis. The two foci in Australia are in Victoria and Far North Queensland. We present the 2009-2015 case series for the Queensland focus with special reference to the 2011 spike of 64 cases. METHODS: This case series is based on a combination of prospectively and retrospectively collected data on 95 confirmed cases of M...
November 1, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27777282/diagnosis-delay-and-duration-of-hospitalisation-of-patients-with-buruli-ulcer-in-nigeria
#16
Anthony O Meka, Joseph N Chukwu, Charles C Nwafor, Daniel C Oshi, Nelson O Madichie, Ngozi Ekeke, Moses C Anyim, Chukwuka Alphonsus, Obinna Mbah, Glory C Uzoukwa, Martin Njoku, Kentigern Ntana, Kingsley N Ukwaja
BACKGROUND: Delayed diagnosis of Buruli ulcer can worsen clinical presentation of the disease, prolong duration of management, and impose avoidable additional costs on patients and health providers. We investigated the profile, delays in diagnosis, duration of hospitalisation, and associated factors among patients with Buruli ulcer in Nigeria. METHODS: This was a prospective cohort study of patients with Buruli ulcer who were identified from a community-based survey...
October 23, 2016: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27776120/rna-aptamer-that-specifically-binds-to-mycolactone-and-serves-as-a-diagnostic-tool-for-diagnosis-of-buruli-ulcer
#17
Samuel A Sakyi, Samuel Yaw Aboagye, Isaac Darko Otchere, Albert M Liao, Thomas G Caltagirone, Dorothy Yeboah-Manu
BACKGROUND: Buruli ulcer (BU) is a subcutaneous skin disease listed among the neglected tropical diseases by the World Health Organization (WHO). Early case detection and management is very important to reduce morbidity and the accompanied characteristic disfiguring nature of BU. Since diagnosis based on clinical evidence can lead to misdiagnosis, microbiological confirmation is essential to reduce abuse of drugs; since the anti-mycobacterial drugs are also used for TB treatment. The current WHO gold standard PCR method is expensive, requires infrastructure and expertise are usually not available at the peripheral centers where BU cases are managed...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27755552/sterilizing-activity-of-fully-oral-intermittent-regimens-against-mycobacterium-ulcerans-infection-in-mice
#18
Aurélie Chauffour, Jérôme Robert, Nicolas Veziris, Alexandra Aubry, Vincent Jarlier
BACKGROUND: The treatment of Buruli ulcer (BU) that is caused by Mycobacterium ulcerans, is currently based on a daily administration of rifampin and streptomycin (RIF-STR). A fully oral intermittent regimen would greatly simplify its treatment on the field. METHODOLOGY/PRINCIPAL FINDINGS: The objective of this study was to assess the bactericidal and sterilizing activities of intermittent oral regimens in a murine model of established M. ulcerans infection. Regimens combining rifapentine (RFP 20 mg/kg) with either moxifloxacin (MXF 200 mg/kg), clarithromycin (CLR 100 mg/kg) or bedaquiline (BDQ 25 mg/kg) were administrated twice (2/7) or three (only for RFP-CLR 3/7) times weekly during 8 weeks...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27688344/complete-genome-sequence-of-mycobacterium-ulcerans-subsp-shinshuense
#19
Mitsunori Yoshida, Kazue Nakanaga, Yoshitoshi Ogura, Atsushi Toyoda, Tadasuke Ooka, Yuko Kazumi, Satoshi Mitarai, Norihisa Ishii, Tetsuya Hayashi, Yoshihiko Hoshino
Mycobacterium ulcerans subsp. shinshuense produces mycolactone and causes Buruli ulcer. Here, we report the complete sequence of its genome, which comprises a 5.9-Mb chromosome and a 166-kb plasmid (pShT-P). The sequence will represent the essential data for future phylogenetic and comparative genome studies of mycolactone-producing mycobacteria.
September 29, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27621302/experiences-of-pain-and-expectations-for-its-treatment-among-former-buruli-ulcer-patients
#20
Rebecca J Woolley, Anita Velink, Richard O Phillips, William A Thompson, K Mohammed Abass, Tjip S van der Werf, Janine de Zeeuw, Ymkje Stienstra
Buruli ulcer (BU) is one of the 17 neglected tropical diseases for which the World Health Organization has adopted resolutions to improve treatment. BU was previously described as a relatively painless condition; however, recent research has indicated that some patients experience substantial pain. The objective of this study was to explore patients' experiences of pain and their expectations for its treatment. Semistructured interviews were conducted in a BU-endemic region of Ghana. Interviews were held with former BU patients (N = 20) and community controls (N = 19)...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
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