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Buruli Ulcer

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https://www.readbyqxmd.com/read/28344056/chronic-cutaneous-mycobacterial-ulcers-due-to-mycobacterium-ulcerans-buruli-ulcer-the-first-indigenous-case-report-from-jordan-and-a-literature-review
#1
Jamal Wadi Al Ramahi, Hassan Annab, Mutaz Al Karmi, Basel Kirresh, Mahmoud Wreikat, Rami Batarseh, Muhannad Yacoub, Mais Kaderi
BACKGROUND: Buruli ulcer is the third most common mycobacterial infection worldwide. It is endemic in tropical, subtropical, and temperate climates. It causes devastating disease with morbidity and mortality. The treatment duration is long and the regimens considered are limited. Chronic cutaneous ulcers of mycobacterial etiology have been reported previously in Amman, but these were not associated with Mycobacterium ulcerans infection. METHODS: The case patient's initial diagnosis was based on chronological and morphological features, combined with appropriate diagnostic tests...
March 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28329001/experimental-demonstration-of-the-possible-role-of-acanthamoeba-polyphaga-in-the-infection-and-disease-progression-in-buruli-ulcer-bu-using-icr-mice
#2
Bright K Azumah, Phyllis G Addo, Alfred Dodoo, Gordon Awandare, Lydia Mosi, Daniel A Boakye, Michael D Wilson
The transmission of Buruli ulcer (BU), caused by Mycobacterium ulcerans (MU), remains puzzling although a number of hypothesis including through bites of infected aquatic insects have been proposed. We report the results of experiments using ICR mice that give credence to our hypothesis that Acanthamoeba species may play a role in BU transmission. We cocultured MU N2 and MU 1615 which expresses red fluorescent protein (RFP) and Acanthamoeba polyphaga (AP), and confirmed infected AP by Ziehl-Neelsen (ZN) staining...
2017: PloS One
https://www.readbyqxmd.com/read/28315039/ecology-and-feeding-habits-drive-infection-of-water-bugs-with-mycobacterium-ulcerans
#3
Solange Meyin A Ebong, Gabriel E García-Peña, Dominique Pluot-Sigwalt, Laurent Marsollier, Philippe Le Gall, Sara Eyangoh, Jean-François Guégan
Mycobacterium ulcerans (MU), the causative agent of Buruli ulcer, is present in a wide spectrum of environments, including terrestrial and aquatic ecosystems in tropical regions. The most promising studies on the epidemiological risk of this disease suggest that some ecological settings may favor infection of animals with MU including human. A species' needs and impacts on resources and the environment, i.e., its ecological niche, may influence its susceptibility to be infected by this microbial form. For example, some Naucoridae may dive in fresh waters to prey upon infected animals and thus may get infected with MU...
March 17, 2017: EcoHealth
https://www.readbyqxmd.com/read/28294596/the-macrolide-toxin-mycolactone-promotes-bim-dependent-apoptosis-in-buruli-ulcer-through-inhibition-of-mtor
#4
Raphael Bieri, Nicole Scherr, Marie-Thérèse Ruf, Jean-Pierre Dangy, Philipp Gersbach, Matthias Gehringer, Karl-Heinz Altmann, Gerd Pluschke
Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, is central to the pathogenesis of the chronic necrotizing skin disease Buruli ulcer (BU). Here we show that mycolactone acts as an inhibitor of the mechanistic Target of Rapamycin (mTOR) signaling pathway by interfering with the assembly of the two distinct mTOR protein complexes mTORC1 and mTORC2, which regulate different cellular processes. Inhibition of the assembly of the rictor containing mTORC2 complex by mycolactone prevents phosphorylation of the serine/threonine protein kinase Akt...
March 27, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28265515/genomic-analysis-of-st88-community-acquired-methicillin-resistant-staphylococcus-aureus-in-ghana
#5
Grace Kpeli, Andrew H Buultjens, Stefano Giulieri, Evelyn Owusu-Mireku, Samuel Y Aboagye, Sarah L Baines, Torsten Seemann, Dieter Bulach, Anders Gonçalves da Silva, Ian R Monk, Benjamin P Howden, Gerd Pluschke, Dorothy Yeboah-Manu, Timothy Stinear
BACKGROUND: The emergence and evolution of community-acquired methicillin resistant Staphylococcus aureus (CA-MRSA) strains in Africa is poorly understood. However, one particular MRSA lineage called ST88, appears to be rapidly establishing itself as an "African" CA-MRSA clone. In this study, we employed whole genome sequencing to provide more information on the genetic background of ST88 CA-MRSA isolates from Ghana and to describe in detail ST88 CA-MRSA isolates in comparison with other MRSA lineages worldwide...
2017: PeerJ
https://www.readbyqxmd.com/read/28245242/assessing-and-managing-wounds-of-buruli-ulcer-patients-at-the-primary-and-secondary-health-care-levels-in-ghana
#6
Naa Okaikor Addison, Stefanie Pfau, Eric Koka, Samuel Yaw Aboagye, Grace Kpeli, Gerd Pluschke, Dorothy Yeboah-Manu, Thomas Junghanss
BACKGROUND: Beyond Mycobacterium ulcerans-specific therapy, sound general wound management is required for successful management of Buruli ulcer (BU) patients which places them among the large and diverse group of patients in poor countries with a broken skin barrier. METHODS: Clinically BU suspicious patients were enrolled between October 2013 and August 2015 at a primary health care (PHC) center and a municipal hospital, secondary health care (SHC) center in Ghana...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28242097/cutaneous-basidiobolomycosis-seven-cases-in-southern-benin
#7
F Atadokpédé, J Gnossikè, H Adégbidi, B Dégboé, Y Sissinto-Savi de Tovè, A Adéyé, C Koudoukpo, A Chauty, D Chabasse, J-P Saint-André, M-T Dieng, M-C Koeppel, H-G Yedomon, F do-Ango-Padonou
BACKGROUND: Cutaneous basidiobolomycosis is the most common form of entomophthoramycosis. Herein we report seven cases of cutaneous basidiobolomycosis. PATIENTS AND METHODS: A retrospective observational study was conducted at the Buruli ulcer treatment centre in Pobè and at the national teaching hospital in Cotonou from 2010 to 2015. RESULTS: Seven cases of cutaneous basidiobolomycosis were diagnosed. The mean patient age was 9.53 years...
February 24, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/28241036/analysis-of-mycobacterium-ulcerans-specific-t-cell-cytokines-for-diagnosis-of-buruli-ulcer-disease-and-as-potential-indicator-for-disease-progression
#8
Norman Nausch, Daniel Antwi-Berko, Yusif Mubarik, Kabiru Mohammed Abass, Wellington Owusu, Ellis Owusu-Dabo, Linda Batsa Debrah, Alexander Yaw Debrah, Marc Jacobsen, Richard O Phillips
BACKGROUND: Buruli ulcer disease (BUD), caused by Mycobacterium (M.) ulcerans, is the third most common mycobacterial disease after tuberculosis and leprosy. BUD causes necrotic skin lesions and is a significant problem for health care in the affected countries. As for other mycobacterial infections, T cell mediated immune responses are important for protection and recovery during treatment, but detailed studies investigating these immune responses in BUD patients are scarce. In this study, we aimed to characterise M...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28238016/seasonal-pattern-of-mycobacterium-ulcerans-the-causative-agent-of-buruli-ulcer-in-the-environment-in-ghana
#9
Samuel Yaw Aboagye, Kobina Assan Ampah, Amanda Ross, Prince Asare, Isaac Darko Otchere, Janet Fyfe, Dorothy Yeboah-Manu
This study aimed to contribute to the understanding of Mycobacterium ulcerans (MU) ecology by analysing both clinical and environmental samples collected from ten communities along two major river basins (Offin and Densu) associated with Buruli ulcer (BU) at different seasons. We collected clinical samples from presumptive BU cases and environmental samples from ten communities. Following DNA extraction, clinical samples were confirmed by IS2404 PCR and environmental samples were confirmed by targeting MU-specific genes, IS2404, IS2606 and the ketoreductase (KR) using real-time PCR...
February 25, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28229230/mycobacterium-ulcerans-mycolactone-interferes-with-adhesion-migration-and-proliferation-of-primary-human-keratinocytes-and-hacat-cell-line
#10
Francesca Graziola, Elena Colombo, Rossana Tiberio, Giorgio Leigheb, Chiarella Bozzo
The pathogenicity of Mycobacterium ulcerans (Buruli ulcer) is closely associated with the secretion of exotoxin mycolactone. The cytotoxicity of mycolactone has been linked to its apoptogenic activity. We explored if low mycolactone concentrations, which are not able to induce apoptosis, can influence other essential activities on two primary human keratinocyte populations, keratinocyte stem cells (KSC) and transit amplifying cells (TAC), and on a human keratinocyte line, HaCaT. We demonstrated that 0.01 and 0...
April 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28219954/mycolactone-reveals-substrate-driven-complexity-of-sec61-dependent-transmembrane-protein-biogenesis
#11
Michael McKenna, Rachel E Simmonds, Stephen High
Mycolactone is the exotoxin virulence factor produced by Mycobacterium ulcerans, the pathogen responsible for Buruli ulcer. The skin lesions and immunosuppression characteristic of this disease result from the action of mycolactone, which targets the Sec61 complex and inhibits the co-translational translocation of secretory proteins into the endoplasmic reticulum. In this study, we investigate the effect of mycolactone on the Sec61-dependent biogenesis of different classes of transmembrane protein (TMP). Our data suggest that the effect of mycolactone on TMP biogenesis depends on how the nascent chain initially engages the Sec61 complex...
February 20, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28208653/molecular-characterization-of-mycolactone-producing-mycobacteria-from-aquatic-environments-in-buruli-ulcer-non-endemic-areas-in-c%C3%A3-te-d-ivoire
#12
Marcellin B Tano, Christelle Dassi, Lydia Mosi, Marina Koussémon, Bassirou Bonfoh
Non-tuberculous mycobacteria (NTM), particularly mycolactone producing mycobacteria (MPM), are bacteria found in aquatic environments causing skin diseases in humans like Buruli ulcer (BU). Although the causative agent for BU, Mycobacterium ulcerans has been identified and associated with slow-moving water bodies, the real transmission route is still unknown. This study aimed to characterize MPMs from environmental aquatic samples collected in a BU non-endemic community, Adiopodoumé, in Côte d'Ivoire. Sixty samples were collected in four types of matrices (plant biofilms, water filtrate residues, plant detritus and soils) from three water bodies frequently used by the population...
February 11, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28159417/design-synthesis-and-cytotoxicity-of-stabilized-mycolactone-analogs
#13
Vaddela Sudheer Babu, Ya Zhou, Yoshito Kishi
On exposure to visible light, mycolactone A/B, the causative toxin of Buruli ulcer, rearranges to a mixture of four photo-mycolactones apparently via a rare photochemically-induced [4πs+2πa] cycloaddition. In order to prevent the rearrangement, two C6'-C7' dihydromycolactone analogs 6'α-15 and 6'β-15 were designed and synthesized. 6'α-15 and 6'β-15 were shown to be stable under not only photochemical, but also acidic and basic conditions. Cytotoxicity was tested against arbitrarily chosen four cell lines (human Hek-293, human lung carcinoma A-549, human melanoma LOX-IMVI, and mouse L-929), thereby revealing that: (1) both analogs maintain potent cytotoxicity; (2) 6'β-15 exhibits significantly higher potency against human cell lines than 6'α-15; (3) in comparison with parent mycolactone A/B, 6'β-15 exhibits equal potency against human Hek-293, whereas significantly lower potency against human lung carcinoma A-549 and human melanoma LOX-IMVI...
January 17, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28137745/multiple-introductions-and-recent-spread-of-the-emerging-human-pathogen-mycobacterium-ulcerans-across-africa
#14
Koen Vandelannoote, Conor J Meehan, Miriam Eddyani, Dissou Affolabi, Delphin Mavinga Phanzu, Sara Eyangoh, Kurt Jordaens, Françoise Portaels, Kirstie Mangas, Torsten Seemann, Laurent Marsollier, Estelle Marion, Annick Chauty, Jordi Landier, Arnaud Fontanet, Herwig Leirs, Timothy P Stinear, Bouke C de Jong
Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa...
January 30, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28131607/effectiveness-of-purified-methylene-blue-in-an-experimental-model-of-mycobacterium-ulcerans-infection
#15
Roger B D Tian, Shady Asmar, Claude Napez, Hubert Lépidi, Michel Drancourt
Mycobacterium ulcerans is responsible for Buruli ulcer, characterised by extensive, disabling ulcers. Standard treatment combining rifampicin and streptomycin exposes patients to toxicity and daily painful injections. In this study, the in vitro susceptibilities of 3 M. ulcerans strains, 1 Mycobacterium marinum strain and 18 strains representative of eleven other Mycobacterium species and subspecies to methylene blue were determined. Whilst growth of M. ulcerans was inhibited by 0.0125 g/L methylene blue, growth of all other tested strains was not inhibited by 1 g/L methylene blue...
March 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28095422/high-throughput-carbon-substrate-profiling-of-mycobacterium-ulcerans-suggests-potential-environmental-reservoirs
#16
Dezemon Zingue, Amar Bouam, Muriel Militello, Michel Drancourt
BACKGROUND: Mycobacterium ulcerans is a close derivative of Mycobacterium marinum and the agent of Buruli ulcer in some tropical countries. Epidemiological and environmental studies pointed towards stagnant water ecosystems as potential sources of M. ulcerans, yet the ultimate reservoirs remain elusive. We hypothesized that carbon substrate determination may help elucidating the spectrum of potential reservoirs. METHODOLOGY/PRINCIPAL FINDINGS: In a first step, high-throughput phenotype microarray Biolog was used to profile carbon substrates in one M...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28073729/phytotherapy-against-buruli-ulcer-in-the-health-district-of-yamoussoukro-cote-d-ivoire-%C3%A2-identification-description-and-symbolic-functions-of-the-plants-and-recipes-used
#17
A A Adjet, D Kouame, G Fokou
This study aims to describe the plants and recipes proposed by traditional healers against Buruli ulcer in Côte d'Ivoire and to analyze their symbolic aspects. Buruli ulcer is an increasingly serious health problem in Côte d'Ivoire. The ivorian state through the National Buruli Ulcer Control Programme and its partners, has developed various actions to fight that disease. Medical and surgical treatments are offered free of charge to patients. Hundreds of health centers in different health districts have been converted into Buruli ulcer management centers...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28061905/epidemiology-of-mansonella-perstans-in-the-middle-belt-of-ghana
#18
Linda Batsa Debrah, Norman Nausch, Vera Serwaa Opoku, Wellington Owusu, Yusif Mubarik, Daniel Antwi Berko, Samuel Wanji, Laura E Layland, Achim Hoerauf, Marc Jacobsen, Alexander Yaw Debrah, Richard O Phillips
BACKGROUND: Mansonellosis was first reported in Ghana by Awadzi in the 1990s. Co-infections of Mansonella perstans have also been reported in a small cohort of patients with Buruli ulcer and their contacts. However, no study has assessed the exact prevalence of the disease in a larger study population. This study therefore aimed to find out the prevalence of M. perstans infection in some districts in Ghana and to determine the diversity of Culicoides that could be potential vectors for transmission...
January 7, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28056807/evaluating-decontamination-protocols-for-the-isolation-of-mycobacterium-ulcerans-from-swabs
#19
Enid Owusu, Mercy J Newman, Amos Akumwena, Elizabeth Bannerman, Gerd Pluschke
BACKGROUND: Mycobacterium ulcerans (M. ulcerans) is the causative agent of Buruli Ulcer (BU) disease. In order to inhibit the growth of the microbial contaminants during culture of M. ulcerans, it is necessary to decontaminate BU samples with effective chemical agents. This study aimed at investigating some selected chemicals as potential decontamination agents for the isolation of M. ulcerans from swabs. RESULTS: Povidone iodine at 0.5 and 1% exhibited the lowest contamination and recovery rate for microbial contaminants and M...
January 5, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28043557/antimycobacterial-potency-and-cytotoxicity-study-of-three-medicinal-plants
#20
Patrick Valere Tsouh Fokou, Regina Appiah-Opong, Dorothy Yeboah-Manu, Abena Adomah Kissi-Twum, Lauve Rachel Tchokouaha Yamthe, Aristide Laurel Mokale Kognou, Phyllis Addo, Fabrice Fekam Boyom, Alexander Kwadwo Nyarko
OBJECTIVE/BACKGROUND: Mycobacterial infections including tuberculosis, leprosy, and buruli ulcer are among the most prevalent, debilitating, and deadly tropical diseases, especially in Sub-Saharan Africa. The development of drug resistance to the currently available drugs and the poor compliance emphasize the need for new chemotherapeutic agents. This study was designed to evaluate the in vitro activity of Cleistopholis patens, Annona reticulata, and Greenwayodendron suaveolens against Mycobacterium smegmatis...
December 2016: International Journal of Mycobacteriology
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