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Buruli Ulcer

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https://www.readbyqxmd.com/read/29642809/a-severe-case-of-em-mycobacterium-ulcerans-em-buruli-ulcer-osteomyelitis-requiring-a-below-knee-amputation
#1
Michael J Loftus, Nicola Kettleton-Butler, Denton Wade, R Michael Whitby, Paul Dr Johnson
No abstract text is available yet for this article.
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29642808/tackling-the-worsening-epidemic-of-buruli-ulcer-in-australia-in-an-information-void-time-for-an-urgent-scientific-response
#2
Daniel P O'Brien, Eugene Athan, Kim Blasdell, Paul De Barro
No abstract text is available yet for this article.
April 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29605498/delayed-versus-standard-assessment-for-excision-surgery-in-patients-with-buruli-ulcer-in-benin-a-randomised-controlled-trial
#3
Akpeedje C Wadagni, Yves T Barogui, Roch C Johnson, Ghislain E Sopoh, Dissou Affolabi, Tjip S van der Werf, Janine de Zeeuw, Johanneke Kleinnijenhuis, Ymkje Stienstra
BACKGROUND: Surgical intervention was once the mainstay of treatment for Buruli ulcer disease, a neglected tropical disease caused by Mycobacterium ulcerans. Since the introduction of streptomycin and rifampicin for 8 weeks as standard care, surgery has persisted as an adjunct therapy, but its role is uncertain. We investigated the effect of delaying the decision to operate to 14 weeks on rates of healing without surgery. METHODS: In this randomised controlled trial, we enrolled patients aged 3 years or older with confirmed disease at one hospital in Lalo, Benin...
March 28, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29605497/surgery-for-buruli-ulcer-in-the-antibiotic-era
#4
Paul D R Johnson
No abstract text is available yet for this article.
March 28, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29584724/developing-a-buruli-ulcer-community-of-practice-in-bankim-cameroon-a-model-for-buruli-ulcer-outreach-in-africa
#5
Paschal Kum Awah, Alphonse Um Boock, Ferdinand Mou, Joseph Tohnain Koin, Evaristus Mbah Anye, Djeunga Noumen, Mark Nichter
BACKGROUND: In the Cameroon, previous efforts to identify Buruli ulcer (BU) through the mobilization of community health workers (CHWs) yielded poor results. In this paper, we describe the successful creation of a BU community of practice (BUCOP) in Bankim, Cameroon composed of hospital staff, former patients, CHWs, and traditional healers. METHODS AND PRINCIPLE FINDINGS: All seven stages of a well-defined formative research process were conducted during three phases of research carried out by a team of social scientists working closely with Bankim hospital staff...
March 27, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29554096/the-incubation-period-of-buruli-ulcer-mycobacterium-ulcerans-infection-in-victoria-australia-remains-similar-despite-changing-geographic-distribution-of-disease
#6
Michael J Loftus, Jason A Trubiano, Ee Laine Tay, Caroline J Lavender, Maria Globan, Janet A M Fyfe, Paul D R Johnson
BACKGROUND: Buruli ulcer (BU) is a geographically-restricted infection caused by Mycobacterium ulcerans; contact with an endemic region is the primary risk factor for disease acquisition. Globally, efforts to estimate the incubation period of BU are often hindered as most patients reside permanently in endemic areas. However, in the south-eastern Australian state of Victoria, a significant proportion of people who acquire BU are visitors to endemic regions. During a sustained outbreak of BU on the Bellarine peninsula we estimated a mean incubation period of 4...
March 19, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29545962/subcutaneous-granulomatous-inflammation-due-to-basidiobolomycosis-case-reports-of-3-patients-in-buruli-ulcer-endemic-areas-in-benin
#7
Luc V C Brun, Jean Jacques Roux, Ghislain E Sopoh, Julia Aguiar, Miriam Eddyani, Wayne M Meyers, Dirk Stubbe, Marie T Akele Akpo, Françoise Portaels, Bouke C de Jong
Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for Basidiobolus ranarum and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29540678/inhibition-of-sec61-dependent-translocation-by-mycolactone-uncouples-the-integrated-stress-response-from-er-stress-driving-cytotoxicity-via-translational-activation-of-atf4
#8
Joy Ogbechi, Belinda S Hall, Thomas Sbarrato, Jack Taunton, Anne E Willis, Ronald C Wek, Rachel E Simmonds
Mycolactone is the exotoxin virulence factor of Mycobacterium ulcerans that causes the neglected tropical disease Buruli ulcer. We recently showed it to be a broad spectrum inhibitor of Sec61-dependent co-translational translocation of proteins into the endoplasmic reticulum (ER). An outstanding question is the molecular pathway linking this to its known cytotoxicity. We have now used translational profiling to better understand the reprogramming that occurs in cells exposed to mycolactone. Gene ontology identified enrichment in genes involved in cellular response to stress, and apoptosis signalling among those showing enhanced translation...
March 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29538643/diagnostic-tests-for-buruli-ulcer-clinical-judgment-revisited
#9
Tjip S van der Werf
No abstract text is available yet for this article.
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29538642/diagnostic-accuracy-of-clinical-and-microbiological-signs-in-patients-with-skin-lesions-resembling-buruli-ulcer-in-an-endemic-region
#10
Miriam Eddyani, Ghislain E Sopoh, Gilbert Ayelo, Luc V C Brun, Jean-Jacques Roux, Yves Barogui, Dissou Affolabi, William R Faber, Marleen Boelaert, Annelies Van Rie, Françoise Portaels, Bouke C de Jong
Background: The diagnosis of the neglected tropical skin and soft tissue disease Buruli ulcer (BU) is made on clinical and epidemiological grounds, after which treatment with BU-specific antibiotics is initiated empirically. Given the current decline in BU incidence, clinical expertise in the recognition of BU is likely to wane and laboratory confirmation of BU becomes increasingly important. We therefore aimed to determine the diagnostic accuracy of clinical signs and microbiological tests in patients presenting with lesions clinically compatible with BU...
March 10, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29529087/implementation-of-a-decentralized-community-based-treatment-program-to-improve-the-management-of-buruli-ulcer-in-the-ouinhi-district-of-benin-west-africa
#11
Arnaud Setondji Amoussouhoui, Ghislain Emmanuel Sopoh, Anita Carolle Wadagni, Roch Christian Johnson, Paulin Aoulou, Inès Elvire Agbo, Jean-Gabin Houezo, Micah Boyer, Mark Nichter
BACKGROUND: Mycobacterium ulcerans infection, commonly known as Buruli ulcer (BU), is a debilitating neglected tropical disease. Its management remains complex and has three main components: antibiotic treatment combining rifampicin and streptomycin for 56 days, wound dressings and skin grafts for large ulcerations, and physical therapy to prevent functional limitations after care. In Benin, BU patient care is being integrated into the government health system. In this paper, we report on an innovative pilot program designed to introduce BU decentralization in Ouinhi district, one of Benin's most endemic districts previously served by centralized hospital-based care...
March 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29522516/report-of-a-series-of-82-cases-of-buruli-ulcer-from-nigeria-treated-in-benin-from-2006-to-2016
#12
Gilbert Adjimon Ayelo, Esai Anagonou, Anita Carolle Wadagni, Yves Thierry Barogui, Ange Dodji Dossou, Jean Gabin Houezo, Julia Aguiar, Roch Christian Johnson, Raoul Saizonou, Kingsley Asiedu, Ghislain Emmanuel Sopoh
BACKGROUND: Nigeria is one of the countries endemic for Buruli ulcer (BU) in West Africa but did not have a control programme until recently. As a result, BU patients often access treatment services in neighbouring Benin where dedicated health facilities have been established to provide treatment free of charge for BU patients. This study aimed to describe the epidemiological, clinical, biological and therapeutic characteristics of cases from Nigeria treated in three of the four treatment centers in Benin...
March 9, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29401455/membrane-perturbing-properties-of-toxin-mycolactone-from-mycobacterium-ulcerans
#13
Cesar A López, Clifford J Unkefer, Basil I Swanson, Jessica M J Swanson, S Gnanakaran
Mycolactone is the exotoxin produced by Mycobacterium ulcerans and is the virulence factor behind the neglected tropical disease Buruli ulcer. The toxin has a broad spectrum of biological effects within the host organism, stemming from its interaction with at least two molecular targets and the inhibition of protein uptake into the endoplasmic reticulum. Although it has been shown that the toxin can passively permeate into host cells, it is clearly lipophilic. Association with lipid carriers would have substantial implications for the toxin's distribution within a host organism, delivery to cellular targets, diagnostic susceptibility, and mechanisms of pathogenicity...
February 5, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29386234/practice-guidelines-for-clinical-microbiology-laboratories-mycobacteria
#14
REVIEW
Betty A Forbes, Geraldine S Hall, Melissa B Miller, Susan M Novak, Marie-Claire Rowlinson, Max Salfinger, Akos Somoskövi, David M Warshauer, Michael L Wilson
Mycobacteria are the causative organisms for diseases such as tuberculosis (TB), leprosy, Buruli ulcer, and pulmonary nontuberculous mycobacterial disease, to name the most important ones. In 2015, globally, almost 10 million people developed TB, and almost half a million patients suffered from its multidrug-resistant form. In 2016, a total of 9,287 new TB cases were reported in the United States. In 2015, there were 174,608 new case of leprosy worldwide. India, Brazil, and Indonesia reported the most leprosy cases...
April 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29372678/-a-papua-new-guinean-with-three-foot-ulcers
#15
A Coenders, M Verregghen, E P Baerends
A 25-year-old Papuan presented with three painless foot ulcers with undermined edges, induration and oedema. The appearance was typical for Buruli ulcer, which is caused by Mycobacterium ulcerans. A smear was positive for acid fast bacilli. Buruli ulcers are found in patients from humid and tropical regions and are treated with rifampicin and streptomycin during eight weeks.
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29361986/perceived-causes-and-risk-factors-of-buruli-ulcer-among-patients-at-agogo-presbyterian-hospital-in-ashanti-region-of-ghana
#16
Reindolf Anokye, Enoch Acheampong, Wisdom Kwadwo Mprah, Edward Sarpong
OBJECTIVE: The incidence of Buruli ulcer has been recorded in about 30 countries globally and Africa seems to be the most affected area. The study sought to determine perceived causes and risk factors of Buruli ulcer among patients who visit the Agogo hospital in Asante-Akim North District in the Ashanti region of Ghana. A descriptive study design was adopted using a simple random sampling technique to select 400 patients attending The Presbyterian Hospital at Agogo. Data was collected using a structured questionnaire and analysed using SPSS version 16...
January 23, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29351741/risk-factors-for-mycobacterium-ulcerans-infection-buruli-ulcer-in-togo-%C3%A2-a-case-control-study-in-zio-and-yoto-districts-of-the-maritime-region
#17
Issaka Maman, Tchadjobo Tchacondo, Abiba Banla Kere, Ebekalisai Piten, Marcus Beissner, Yiragnima Kobara, Komlan Kossi, Kossi Badziklou, Franz Xaver Wiedemann, Komi Amekuse, Gisela Bretzel, Damintoti Simplice Karou
BACKGROUND: Buruli ulcer (BU) is a neglected mycobacterial skin infection caused by Mycobacterium ulcerans. This disease mostly affects poor rural populations, especially in areas with low hygiene standards and sanitation coverage. The objective of this study was to identify these risk factors in the districts of Zio and Yoto of the Maritime Region in Togo. METHODS: We conducted a case-control study in Zio and Yoto, two districts proved BU endemic from November 2014 to May 2015...
January 19, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29343539/buruli-ulcer-review-of-a-neglected-skin-mycobacterial-disease
#18
Jeannette Guarner
Buruli ulcer is caused by Mycobacterium ulcerans This neglected disease occurs in scattered foci around the world with higher concentration of cases in West Africa. The mycobacteria produce mycolactones that cause tissue necrosis. The disease presents as a painless skin nodule that ulcerates as necrosis expands. Finding acid fast bacilli in smears or histopathology, culturing the mycobacteria, and performing M. ulcerans PCR in presumptive cases confirms the diagnosis. Medical treatment with oral rifampicin and intramuscular streptomycin or oral treatment with rifampicin plus clarithromycin for 8 weeks is supported by the World Health Organization...
January 17, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29320578/the-potent-effect-of-mycolactone-on-lipid-membranes
#19
Milène Nitenberg, Anaïs Bénarouche, Ofelia Maniti, Estelle Marion, Laurent Marsollier, Julie Géan, Erick J Dufourc, Jean-François Cavalier, Stéphane Canaan, Agnès P Girard-Egrot
Mycolactone is a lipid-like endotoxin synthesized by an environmental human pathogen, Mycobacterium ulcerans, the causal agent of Buruli ulcer disease. Mycolactone has pleiotropic effects on fundamental cellular processes (cell adhesion, cell death and inflammation). Various cellular targets of mycolactone have been identified and a literature survey revealed that most of these targets are membrane receptors residing in ordered plasma membrane nanodomains, within which their functionalities can be modulated...
January 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29289244/total-syntheses-of-mycolactone-a-b-and-its-analogues-for-the-exploration-of-the-biology-of-buruli-ulcer
#20
Sarah Saint-Auret, Anne-Caroline Chany, Virginie Casarotto, Cédric Tresse, Lise Parmentier, Hajer Abdelkafi, Nicolas Blanchard
Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.
December 1, 2017: Chimia
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