keyword
https://read.qxmd.com/read/38441471/emergence-and-spread-of-mycobacterium-ulcerans-at-different-geographic-scales
#1
JOURNAL ARTICLE
Martial Briand, Alexandra Boccarossa, Adrien Rieux, Marie-Agnès Jacques, Line Ganlanon, Christian Johnson, Matthieu Eveillard, Laurent Marsollier, Estelle Marion
UNLABELLED: The classical lineage of Mycobacterium ulcerans is the most prevalent clonal group associated with Buruli ulcer in humans. Its reservoir is strongly associated with the environment. We analyzed together 1,045 isolates collected from 13 countries on two continents to define the evolutionary history and population dynamics of this lineage. We confirm that this lineage spread over 7,000 years from Australia to Africa with the emergence of outbreaks in distinct waves in the 18th and 19th centuries...
March 5, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38329944/a-lesion-in-two-buruli-ulcer-and-squamous-cell-carcinoma-coexistence
#2
JOURNAL ARTICLE
Jessica C O'Keeffe, Albert H Yin, Daniel P O'Brien
The concurrent diagnoses of Buruli ulcer (BU) and cutaneous squamous cell carcinoma (SCC) is a phenomenon not previously described, despite the fact that both conditions are highly prevalent in Australia. This report presents an intriguing case of concurrent diagnoses, with clues alluding to more than one skin condition being present. The case involves a 73-year-old man with BU diagnosed on the scalp, an atypical location, which led to the consideration of malignancy, ultimately revealing concurrent SCC. This case highlights the importance of considering both conditions in patients with epidemiological risk factors, necessitating multiple lines of investigation for accurate diagnosis...
February 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38295025/unlocking-opportunities-for-mycobacterium-leprae-and-mycobacterium-ulcerans
#3
REVIEW
Mousumi Shyam, Sumit Kumar, Vinayak Singh
In the recent decade, scientific communities have toiled to tackle the emerging burden of drug-resistant tuberculosis (DR-TB) and rapidly growing opportunistic nontuberculous mycobacteria (NTM). Among these, two neglected mycobacteria species of the Acinetobacter family, Mycobacterium leprae and Mycobacterium ulcerans , are the etiological agents of leprosy and Buruli ulcer infections, respectively, and fall under the broad umbrella of neglected tropical diseases (NTDs). Unfortunately, lackluster drug discovery efforts have been made against these pathogenic bacteria in the recent decade, resulting in the discovery of only a few countable hits and majorly repurposing anti-TB drug candidates such as telacebec (Q203), P218, and TB47 for current therapeutic interventions...
January 31, 2024: ACS Infectious Diseases
https://read.qxmd.com/read/38292054/clinical-and-microbiological-predictors-of-healing-in-buruli-ulcer-disease
#4
JOURNAL ARTICLE
Bernadette Agbavor, Abigail Agbanyo, Aloysius Dzigbordi Loglo, Philemon Boasiako Antwi, Nancy Ackam, Jonathan Adjei, Venus Frimpong, Kwadwo Boampong, Michael Frimpong, Matthew Glover Addo, Mark Wansbrough-Jones, Yaw Ampem Amoako, Richard Odame Phillips
INTRODUCTION: Wound measurements are relevant in monitoring the rate of healing (RoH) and may predict time to healing. Predicting the time to healing can help improve the management of Buruli ulcer. We examine three methods for the determination of RoH and their use as predictors of time to healing. METHODS: Lesion measurements of Buruli ulcer patients treated from 2007 to 2022 were obtained with acetate sheet tracings (2D) or Aranz software (3D) fortnightly. RoH was determined using the absolute area, percentage area reduction and linear methods at 4 weeks post onset of antibiotic treatment...
February 2024: Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
https://read.qxmd.com/read/38263455/mosquitoes-spread-the-buruli-ulcer-agent-mycobacterium-ulcerans
#5
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
January 23, 2024: Nature Microbiology
https://read.qxmd.com/read/38263454/mosquitoes-provide-a-transmission-route-between-possums-and-humans-for-buruli-ulcer-in-southeastern-australia
#6
JOURNAL ARTICLE
Peter T Mee, Andrew H Buultjens, Jane Oliver, Karen Brown, Jodie C Crowder, Jessica L Porter, Emma C Hobbs, Louise M Judd, George Taiaroa, Natsuda Puttharak, Deborah A Williamson, Kim R Blasdell, Ee Laine Tay, Rebecca Feldman, Mutizwa Odwell Muzari, Chris Sanders, Stuart Larsen, Simon R Crouch, Paul D R Johnson, John R Wallace, David J Price, Ary A Hoffmann, Katherine B Gibney, Timothy P Stinear, Stacey E Lynch
Buruli ulcer, a chronic subcutaneous infection caused by Mycobacterium ulcerans, is increasing in prevalence in southeastern Australia. Possums are a local wildlife reservoir for M. ulcerans and, although mosquitoes have been implicated in transmission, it remains unclear how humans acquire infection. We conducted extensive field survey analyses of M. ulcerans prevalence among mosquitoes in the Mornington Peninsula region of southeastern Australia. PCR screening of trapped mosquitoes revealed a significant association between M...
January 23, 2024: Nature Microbiology
https://read.qxmd.com/read/38253991/pseudogenomic-insights-into-the-evolution-of-mycobacterium-ulcerans
#7
JOURNAL ARTICLE
Edwin Sakyi Kyei-Baffour, Kwabena Owusu-Boateng, Abiola Isawumi, Lydia Mosi
BACKGROUND: Buruli ulcer (BU) disease, caused by Mycobacterium ulcerans (MU), and characterized by necrotic ulcers is still a health problem in Africa and Australia. The genome of the bacterium has several pseudogenes due to recent evolutionary events and environmental pressures. Pseudogenes are genetic elements regarded as nonessential in bacteria, however, they are less studied due to limited available tools to provide understanding of their evolution and roles in MU pathogenicity. RESULTS: This study developed a bioinformatic pipeline to profile the pseudogenomes of sequenced MU clinical isolates from different countries...
January 22, 2024: BMC Genomics
https://read.qxmd.com/read/38166156/the-current-status-of-neglected-tropical-diseases-in-japan-a-scoping-review
#8
JOURNAL ARTICLE
Yuriko Harada, Hanako Iwashita, Taeko Moriyasu, Sachiyo Nagi, Nobuo Saito, Mariko Sugawara-Mikami, Kota Yoshioka, Rie Yotsu
Little attention has been paid to neglected tropical diseases (NTDs) in high-income countries and no literature provides an overview of NTDs in Japan. This scoping review aims to synthesize the latest evidence and information to understand epidemiology of and public health response to NTDs in Japan. Using three academic databases, we retrieved articles that mentioned NTDs in Japan, written in English or Japanese, and published between 2010 and 2020. Websites of key public health institutions and medical societies were also explored...
January 2, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38118158/mental-health-stigma-and-the-quality-of-life-of-people-affected-by-neglected-tropical-diseases-of-the-skin-in-kasai-province-democratic-republic-of-the-congo-a-sex-disaggregated-analysis
#9
JOURNAL ARTICLE
Maaike L Seekles, Jacob K Kadima, Yan Ding, Christian B Bulambo, Joy J Kim, Junior K Kukola, Pierre O L Omumbu, Raphael M Mulamba, Motto Nganda, Stephanie M Ngenyibungi, Florent L Ngondu, Louis P Sabuni, Laura Dean
BACKGROUND: Worldwide, persons affected by skin Neglected Tropical Diseases (NTDs) may experience stigma and discrimination, which could lead to impaired societal functioning and poor mental wellbeing. Evidence of comorbidity of NTDs and mental health conditions is dominated by Leprosy, largely lacking in post-conflict areas, and rarely disaggregated by sex. METHODS: This cross-sectional survey is the first to explore depression, anxiety, stigma, and quality of life amongst people affected by Lymphatic Filariasis, Buruli Ulcer, Onchocerciasis or Leprosy in the Democratic Republic of the Congo...
December 20, 2023: International Health
https://read.qxmd.com/read/38077720/a-single-synthetic-lipid-antigen-for-improved-serological-diagnosis-of-buruli-ulcer
#10
JOURNAL ARTICLE
J Hacking, V V Gwenin, R J Dacombe, M S Baird, M Frimpong, R O Phillips, C D Gwenin
SETTING: The diagnosis of Buruli ulcer (BU) is frequently made by experienced health workers in rural regions. This leads to long turnaround times to confirm the diagnosis as it requires specialised laboratory infrastructure to perform confirmatory testing. BACKGROUND: Given the lack of success with protein antigens to detect BU in human sera, the aim of this study was to evaluate a range of single synthetic lipid antigens using an enzyme-linked immunosorbent assay (ELISA)...
December 2023: Public Health Action
https://read.qxmd.com/read/38073533/how-our-molecular-understanding-of-the-pathogenesis-of-mycobacterium-ulcerans-infection-can-improve-diagnosis-of-buruli-ulcer
#11
EDITORIAL
Gerd Pluschke, Louisa Warryn
No abstract text is available yet for this article.
December 11, 2023: Expert Review of Molecular Diagnostics
https://read.qxmd.com/read/38060465/mycobacterium-ulcerans-bordetella-trematum-chronic-tropical-cutaneous-ulcer-a-four-case-series-c%C3%A3-te-d-ivoire
#12
JOURNAL ARTICLE
Bi Goré Oscar Tchan, Solange Kakou-Ngazoa, Sylveste Dizoe, Nassim Hammoudi, Ghiles Grine, Raymond Ruimy, Michel Drancourt
BACKGROUND: Chronic tropical cutaneous ulcers remain a neglected medical condition in West Africa, particularly Buruli ulcer, which is caused by mycolactone cytotoxin-secreting Mycobacterium ulcerans (M. ulcerans). Medical management of this highly debilitating and necrotising skin infection may be modified by colonisation and co-infection of the ulcer by opportunistic and pathogenic microorganisms, which considerably delays and increases the cost of treatment. METHODOLOGY/PRINCIPAL FINDING: We diagnosed chronic tropical cutaneous ulcers in nine patients in Côte d'Ivoire using M...
December 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38047835/key-contributions-by-the-swiss-tropical-and-public-health-institute-towards-new-and-better-drugs-for-tropical-diseases
#13
JOURNAL ARTICLE
Pascal Mäser, Sonja Bernhard, Reto Brun, Christian Burri, Sébastien Gagneux, Manuel W Hetzel, Marcel Kaiser, Christian Lengeler, Gerd Pluschke, Elisabeth Reus, Matthias Rottmann, Jürg Utzinger, Louisa Warryn, Sergio Wittlin, Jennifer Keiser
Thanks to its expertise in clinical research, epidemiology, infectious diseases, microbiology, parasitology, public health, translational research and tropical medicine, coupled with deeply rooted partnerships with institutions in low- and middle-income countries (LMICs), the Swiss Tropical and Public Health Institute (Swiss TPH) has been a key contributor in many drug research and development consortia involving academia, pharma and product development partnerships. Our know-how of the maintenance of parasites and their life-cycles in the laboratory, plus our strong ties to research centres and disease control programme managers in LMICs with access to field sites and laboratories, have enabled systems for drug efficacy testing in vitro and in vivo, clinical research, and modelling to support the experimental approaches...
September 20, 2023: Chimia
https://read.qxmd.com/read/38047833/repurposing-of-tuberculosis-drug-candidates-for-the-treatment-of-mycobacterium-ulcerans-disease
#14
JOURNAL ARTICLE
Louisa Warryn, Gerd Pluschke
Buruli ulcer (BU) is a chronic necrotizing skin disease caused by Mycobacterium ulcerans. Historically, the disease was treated by surgical excision of the skin lesions, until an 8-week combination therapy of rifampicin and streptomycin was introduced in 2004. This treatment modality was effective and reduced recurrence rates. Rifampicin is the most efficacious antibiotic for the treatment of BU and, should rifampicin-resistant M. ulcerans strains emerge, there is currently no replacement for it. As for mycobacterial diseases in general, there is a pressing need for the development of novel, fast-acting drugs...
September 20, 2023: Chimia
https://read.qxmd.com/read/38034712/buruli-ulcer-in-africa-geographical-distribution-ecology-risk-factors-diagnosis-and-indigenous-plant-treatment-options-a-comprehensive-review
#15
REVIEW
Jonathan Osei-Owusu, Owusu Fordjour Aidoo, Fatima Eshun, David Sewordor Gaikpa, Aboagye Kwarteng Dofuor, Bright Yaw Vigbedor, Bernard Kofi Turkson, Kingsley Ochar, John Opata, Maxwell Jnr Opoku, Kodwo Dadzie Ninsin, Christian Borgemeister
Buruli ulcer (BU), a neglected tropical disease (NTD), is an infection of the skin and subcutaneous tissue caused by Mycobacterium ulcerans . The disease has been documented in many South American, Asian, and Western Pacific countries and is widespread throughout much of Africa, especially in West and Central Africa. In rural areas with scarce medical care, BU is a devastating disease that can leave patients permanently disabled and socially stigmatized. Mycobacterium ulcerans is thought to produce a mycolactone toxin, which results in necrosis of the afflicted tissue and may be involved in the etiology of BU...
November 2023: Heliyon
https://read.qxmd.com/read/37935359/multi-epitope-vaccine-candidates-based-on-mycobacterial-membrane-protein-large-mmpl-proteins-against-mycobacterium-ulcerans
#16
JOURNAL ARTICLE
Tamara Z Ishwarlall, Victoria T Adeleke, Leah Maharaj, Moses Okpeku, Adebayo A Adeniyi, Matthew A Adeleke
Buruli ulcer (BU) is a neglected tropical disease. It is caused by the bacterium Mycobacterium ulcerans and is characterized by skin lesions. Several studies were performed testing the Bacillus Calmette-Guérin (BCG) vaccine in human and animal models and M. ulcerans- specific vaccines in animal models. However, there are currently no clinically accepted vaccines to prevent M. ulcerans infection. The aim of this study was to identify T-cell and B-cell epitopes from the mycobacterial membrane protein large (MmpL) proteins of M...
November 2023: Open Biology
https://read.qxmd.com/read/37930809/qualitative-study-of-the-stigma-associated-with-the-lived-experiences-of-buruli-ulcer-disease-among-patients-in-nigeria
#17
JOURNAL ARTICLE
Precious Chidozie Azubuike, Uchenna Frank Imo, Chimankpam Kingsley Ogbonna
BACKGROUND: Buruli ulcer disease (BUD) is a neglected tropical disease of the skin, subcutaneous tissue and bone caused by Mycobacterium ulcerans, with various disabling and stigmatising sequelae. Patients face a range of adverse impacts owing to the disease as most are unable to relate effectively with their communities, battling stigma and fear of discrimination. This study aimed to explore the stigma associated with the lived experiences of BUD in patients in Nigeria. METHODS: This was a cross-sectional qualitative study that employed a focus group discussion (FGD) and key informant interviews in Enugu State, Nigeria...
November 1, 2023: International Health
https://read.qxmd.com/read/37910490/inflammasome-triggered-il-18-controls-skin-inflammation-in-the-progression-of-buruli-ulcer
#18
JOURNAL ARTICLE
Toshihiko Suzuki, Kotchakorn Boonyaleka, Tokuju Okano, Tamako Iida, Mitsunori Yoshida, Hanako Fukano, Yoshihiko Hoshino, Yoichiro Iwakura, Anthony S Ablordey, Hiroshi Ashida
Buruli ulcer is an emerging chronic infectious skin disease caused by Mycobacterium ulcerans. Mycolactone, an exotoxin produced by the bacterium, is the only identified virulence factor so far, but the functions of this toxin and the mechanisms of disease progression remain unclear. By interfering Sec61 translocon, mycolactone inhibits the Sec61-dependent co-translational translocation of newly synthesized proteins, such as induced cytokines and immune cell receptors, into the endoplasmic reticulum. However, in regard to IL-1β, which is secreted by a Sec61-independent mechanism, mycolactone has been shown to induce IL-1β secretion via activation of inflammasomes...
November 2023: PLoS Pathogens
https://read.qxmd.com/read/37907954/the-pipeline-for-drugs-for-control-and-elimination-of-neglected-tropical-diseases-2-oral-anti-infective-drugs-and-drug-combinations-for-off-label-use
#19
REVIEW
Kenneth M Pfarr, Anna K Krome, Issraa Al-Obaidi, Hannah Batchelor, Michel Vaillant, Achim Hoerauf, Nicholas O Opoku, Annette C Kuesel
In its 'Road map for neglected tropical diseases 2021-2030', the World Health Organization outlined its targets for control and elimination of neglected tropical diseases (NTDs) and research needed to achieve them. For many NTDs, this includes research for new treatment options for case management and/or preventive chemotherapy. Our review of small-molecule anti-infective drugs recently approved by a stringent regulatory authority (SRA) or in at least Phase 2 clinical development for regulatory approval showed that this pipeline cannot deliver all new treatments needed...
October 31, 2023: Parasites & Vectors
https://read.qxmd.com/read/37840746/repurposing-of-statins-for-buruli-ulcer-treatment-antimicrobial-activity-against-mycobacterium-ulcerans
#20
JOURNAL ARTICLE
Juan Dominguez, Ana I Mendes, Ana R Pacheco, Maria J Peixoto, Jorge Pedrosa, Alexandra G Fraga
Mycobacterium ulcerans causes Buruli Ulcer, a neglected infectious skin disease that typically progresses from an early non-ulcerative lesion to an ulcer with undermined edges. If not promptly treated, these lesions can lead to severe disfigurement and disability. The standard antibiotic regimen for Buruli Ulcer treatment has been oral rifampicin combined with intramuscular streptomycin administered daily for 8 weeks. However, there has been a recent shift toward replacing streptomycin with oral clarithromycin...
2023: Frontiers in Microbiology
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