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Oesophagus surgery

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https://www.readbyqxmd.com/read/28637650/achalasia-leading-to-diagnosis-of-adenocarcinoma-of-the-oesophagus
#1
Jonathan Segal, Ayodele Lagundoye, Martyn Carter
A 50-year-old male with a 7 month history of progressive dysphagia to solids then subsequently to liquids. He underwent a diagnostic gastroscopy which was normal. A further barium swallow suggested achalasia. He was referred to a tertiary centre, where he underwent pH and manometry studies which confirmed a diagnosis of achalasia. He was referred for a laparoscopic cardiomyotomy, and at surgery there was a suspected tumour at the gastro-oesophageal junction. A follow-up endoscopy with biopsies was normal...
June 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28607296/a-case-report-of-oesophageal-schwannoma-with-thoracoscopic-surgery
#2
Zhiliang Hu, Zhun He, Xianfeng Li, Chuanliang Peng, Zhen Li
Oesophageal schwannomas is a rare tumour and most commonly found incidentally or from diagnostic workup of dysphagia or dyspnoea. Most oesophageal schwannomas are benign and more frequently occurs in female than in the male. To date, <40 cases have been described in the English literature. In this study, we reported the case of a 57-year-old woman visited our hospital with the symptom of long-time dysphagia. A thoracic computed tomography demonstrated an upper oesophageal well marginated and homogeneous mass that adhered to the right wall of the oesophagus...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28600380/cohort-profile-the-nordic-antireflux-surgery-cohort-nordasco
#3
John Maret-Ouda, Karl Wahlin, Miia Artama, Nele Brusselaers, Martti Färkkilä, Elsebeth Lynge, Fredrik Mattsson, Eero Pukkala, Pål Romundstad, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren
PURPOSE: To describe a newly created all-Nordic cohort of patients with gastro-oesophageal reflux disease (GORD), entitled the Nordic Antireflux Surgery Cohort (NordASCo), which will be used to compare participants having undergone antireflux surgery with those who have not regarding risk of cancers, other diseases and mortality. PARTICIPANTS: Included were individuals with a GORD diagnosis recorded in any of the nationwide patient registries in the Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) in 1964-2014 (with various start and end years in different countries)...
June 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28578652/icorg-10-14-neoadjuvant-trial-in-adenocarcinoma-of-the-oesophagus-and-oesophagogastric-junction-international-study-neo-aegis
#4
J V Reynolds, S R Preston, B O'Neill, L Baeksgaard, S M Griffin, C Mariette, S Cuffe, M Cunningham, T Crosby, I Parker, K Hofland, G Hanna, L B Svendsen, C L Donohoe, C Muldoon, D O'Toole, C Johnson, N Ravi, G Jones, A K Corkhill, M Illsley, J Mellor, K Lee, M Dib, V Marchesin, M Cunnane, K Scott, P Lawner, S Warren, S O'Reilly, G O'Dowd, G Leonard, B Hennessy, R Mc Dermott
BACKGROUND: Neoadjuvant therapy is increasingly the standard of care in the management of locally advanced adenocarcinoma of the oesophagus and junction (AEG). In randomised controlled trials (RCTs), the MAGIC regimen of pre- and postoperative chemotherapy, and the CROSS regimen of preoperative chemotherapy combined with radiation, were superior to surgery only in RCTs that included AEG but were not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemotherapy and neoadjuvant chemoradiation...
June 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28571208/giant-leiomyoma-of-the-oesophagus
#5
Dhamodaran Kandasamy, Niyas Ahamed, Sujatha Kannan, Vasundaran Samuel
Leiomyomas are rare benign tumours of the oesophagus that remain silent in more than 50% of the cases. Giant leiomyomas measuring more than 5 cm are very rare. A 47-year-old female presented with chest pain, cough and dysphagia for two months. Imaging studies were indicative of a 12.1x11.9 cm mass lesion in the distal oesophagus, CT guided biopsy confirmed leiomyoma. The patient being taken up for surgery was found to have a 20x19x17 cm irregular lobulated and encapsulated mass lesion arising from distal oesophagus encapsulating submucosally...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28550507/histopathologic-features-are-more-important-prognostic-factors-than-primary-tumour-location-in-gastro-oesophageal-adenocarcinoma-treated-with-preoperative-chemoradiation-and-surgery
#6
Milan Vošmik, Jan Laco, Igor Sirák, Josef Dvořák, Petr Lochman, Miroslav Hodek, Petra Malá, Stanislav Rejchrt, Rudolf Repák, Michal Leško, Alexander Ferko, Aleš Ryška, Bohuslav Melichar, Jiří Petera
The aim of present study was to evaluate the impact of primary tumour location and other factors on the outcome of preoperative chemoradiation followed by surgery in adenocarcinomas of distal oesophagus, gastro-oesophageal junction and stomach. We retrospectively reviewed the institutional patient database. The therapeutic response was re-evaluated as a percentage of residual tumor cells in surgical resection specimens. Overall survival (OS) and disease-free survival (DFS) were assessed. The effect primary tumour location, clinical and pathological TNM stage, and histopathological factors (histological type, grade, angioinvasion, perineural invasion, tumour response) on treatment outcome were evaluated...
May 27, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28539129/double-aortic-arch-presenting-with-a-foreign-object-in-the-oesophagus-a-case-report-and-imaging-diagnosis
#7
Xiuzhen Yang, Jingjing Ye, Zhan Gao
In this article, we report a rare case of double aortic arch. The case presented initially with a foreign object in the oesophagus. The patient was a 2-year-old boy, who was referred with primary symptoms of tussis (15 days) and emesis (2 days). He had a history of ingesting a coin. Routine chest X-ray indicated a rounded, metal foreign object in the upper oesophagus. A half-Yuan coin was removed by gastroduodenoscopy. Echocardiographic imaging suggested that the patient had double aortic arch, which was subsequently diagnosed by CT angiography with three-dimensional reconstruction...
May 25, 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/28462649/postoperative-survival-following-perioperative-magic-versus-neoadjuvant-oe02-type-chemotherapy-in-oesophageal-adenocarcinoma
#8
A M Reece-Smith, J H Saunders, I N Soomro, C R Bowman, J P Duffy, P V Kaye, N T Welch, S Madhusudan, S L Parsons
The optimal management of resectable oesophageal adenocarcinoma is controversial, with many centres using neoadjuvant chemotherapy following the Medical Research Council (MRC) oesophageal working group (OE02) trial and the MRC Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial. The more intensive MAGIC regimen is used primarily in gastric cancer but some also use it for oesophageal cancer. A database of cancer resections (2001-2013) provided information on survival of patients following either OE02 or MAGIC-type treatment...
May 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28433494/patterns-of-care-and-clinical-outcomes-in-primary-oesophageal-gastrointestinal-stromal-tumours-gist-a-retrospective-study-of-the-french-sarcoma-group-fsg
#9
F Duffaud, P Meeus, F Bertucci, J-B Delhorme, E Stoeckle, N Isambert, E Bompas, J Gagniere, O Bouché, M Toulmonde, S Salas, J-Y Blay, S Bonvalot
BACKGROUND: Oesophageal GIST (ESOGIST) are very rare tumours requiring special consideration regarding diagnosis, surgical management, and perioperative treatment. METHODS: A retrospective study was conducted across 9 centres in the French Sarcoma Group (FSG) to characterize all patients in the years 2000-2014. RESULTS: Seventeen patients (pts) with primary localized ESOGIST were identified, with median age 69 years (36-81) and 11 females...
April 1, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28326569/the-dynamics-of-the-oesophageal-squamous-epithelium-normalisation-process-in-patients-with-gastro-oesophageal-reflux-disease-treated-with-long-term-acid-suppression-or-anti-reflux-surgery
#10
RANDOMIZED CONTROLLED TRIAL
L Mastracci, R Fiocca, C Engström, S Attwood, C Ell, J P Galmiche, J G Hatlebakk, G Långström, S Eklund, T Lind, L Lundell
BACKGROUND: Proton pump inhibitors and laparoscopic anti-reflux surgery (LARS) offer long-term symptom control to patients with gastro-oesophageal reflux disease (GERD). AIM: To evaluate the process of 'normalisation' of the squamous epithelium morphology of the distal oesophagus on these therapies. METHODS: In the LOTUS trial, 554 patients with chronic GERD were randomised to receive either esomeprazole (20-40 mg daily) or LARS. After 5 years, 372 patients remained in the study (esomeprazole, 192; LARS, 180)...
May 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28278490/outcomes-after-oesophageal-perforation-a-retrospective-cohort-study-of-patients-with-different-aetiologies
#11
T T Law, J Yl Chan, D Kk Chan, D Tong, I Yh Wong, F Sy Chan, S Law
INTRODUCTION: The mortality rate after oesophageal perforation is high despite advances in operative and non-operative techniques. In this study, we sought to identify risk factors for hospital mortality. METHODS: We retrospectively examined patients treated for oesophageal perforation in a university teaching hospital in Hong Kong between January 1997 and December 2013. Their demographic and clinical characteristics, aetiology, management strategies, and outcomes were recorded and analysed...
March 10, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28265737/step-down-approach-for-pharyngoesophageal-corrosive-stricture-outcome-and-analysis
#12
Sundeep Singh Saluja, Vaibhav Kumar Varshney, Pramod Kumar Mishra, Siddharth Srivastava, Ravi Meher, Pritul Saxena
BACKGROUND: Pharyngoesophageal stricture (PES) is an Achilles' heel in the management of corrosive injury. Advances in endoscopic techniques were utilized in its management. We classified the stricture as per its dilatability and then planned their treatment. METHODS: PES was sub-categorized based on endoscopic dilatation and availability of cervical oesophagus: group-1 stricture with available cervical oesophagus; group-2 stricture with some part of upper oesophagus made available after endoscopic dilatation and anastomosis in cervico-pharyngeal area; group-3 stricture not amenable for dilatation, anastomosis done at the pharynx...
March 6, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28149589/unusual-clotted-haemothorax-caused-by-spontaneous-intramural-haematoma-of-the-oesophagus-a-case-report
#13
Chenglin Guo, Jiandong Mei, Pujun Guan, Feng Lin, Qiang Pu, Lunxu Liu
Spontaneous intramural haematoma of the oesophagus (SIHO) is a relatively rare event with benign courses. Most of the patients with SIHO may experience spontaneous healing without complications. We report a case of SIHO with clotted haemothorax. Uniportal video-assisted thoracic surgery (VATS) was successfully applied as a diagnostic and therapeutic method. Although conservative treatment is adequate for the majority of patients with SIHO, uniportal VATS may be a suitable option if there was clotted haemothorax...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28108931/systematic-review-and-meta-analysis-of-surgicaltreatment-of-non-zenker-s-oesophageal-diverticula
#14
David S Y Chan, Antonio Foliaki, Wyn G Lewis, Geoffrey W B Clark, Guy R J C Blackshaw
BACKGROUND: Oesophageal diverticula are rare outpouchings of the oesophagus which may be classified anatomically as pharyngeal (Zenker's), mid-oesophageal and epiphrenic. While surgery is indicated for symptomatic patients, no consensus exists regarding the optimum technique for non-Zenker's oesophageal diverticula. The aim of this study was to determine the outcome of surgery in patients with non-Zenker's oesophageal diverticula. METHODS: PubMed, MEDLINE and the Cochrane Library (January 1990 to January 2016) were searched for studies which reported outcomes of surgery in patients with non-Zenker's oesophageal diverticula...
June 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28077503/european-association-for-cardio-thoracic-surgery-expert-consensus-statement-on-the-prevention-and-management-of-mediastinitis
#15
Yasir Abu-Omar, Gregor J Kocher, Paolo Bosco, Cristina Barbero, David Waller, Tomas Gudbjartsson, Miguel Sousa-Uva, Peter B Licht, Joel Dunning, Ralph A Schmid, Giuseppe Cardillo
Mediastinitis continues to be an important and life-threatening complication after median sternotomy despite advances in prevention and treatment strategies, with an incidence of 0.25-5%. It can also occur as extension of infection from adjacent structures such as the oesophagus, airways and lungs, or as descending necrotizing infection from the head and neck. In addition, there is a chronic form of 'chronic fibrosing mediastinitis' usually caused by granulomatous infections. In this expert consensus, the evidence for strategies for treatment and prevention of mediatinitis is reviewed in detail aiming at reducing the incidence and optimizing the management of this serious condition...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28072456/systemic-inflammatory-markers-and-outcome-in-patients-with-locally-advanced-adenocarcinoma-of-the-oesophagus-and-gastro-oesophageal-junction
#16
V P Jagadesham, S M Lagarde, A Immanuel, S M Griffin
BACKGROUND: Raised levels of systemic inflammatory markers are associated with poor survival in patients with cancer. The aim of this study was to assess the prognostic value of markers of systemic inflammation in patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction. METHODS: Data from a consecutive series of patients undergoing transthoracic oesophagectomy following neoadjuvant therapy at a single centre were analysed. Fibrinogen, albumin, C-reactive protein, leucocyte differential and platelet counts were measured before surgery...
March 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27895081/malignant-melanoma-of-cervix
#17
Mayank Gupta
A 68-year-old woman presented with symptoms of bleeding per vaginum. On examination, a growth was seen in the cervix, clinically considered to be squamous cell carcinoma. The growth was confined to the cervix and did not involve the parametria. However, on biopsy it was diagnosed as malignant melanoma. She underwent surgery elsewhere and was advised chemotherapy as these tumours are aggressive; however, she refused chemotherapy. She has been on regular follow-up and has an ongoing survival and disease-free period of more than 5 years...
November 28, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27888864/oesophageal-disease-gastroesophageal-reflux-disease-barrett-s-oesophagus-achalasia-and-eosinophilic-oesophagitis
#18
Xavier Calvet
The most interesting conclusions and/or advances presented at Digestive Disease Week 2016 were the following: a) gastroesophageal reflux disease: proton pump inhibitor-refractory reflux disease is frequently associated with poor treatment adherence, psychiatric comorbidities and functional gastrointestinal disorders. These possible entities should be investigated in all cases of proton pump inhibitor-refractory reflux disease; b) Barrett's oesophagus: the efficacy of screening remains unclear; however, new minimally-invasive techniques such as the cytosponge allow more effective detection, both of Barrett's oesophagus and Barrett's oesophagus-associated dysplasia or neoplasia; c) achalasia: evidence indicates that peroral endoscopic myotomy is as effective as surgery and is a safer alternative; d) eosinophilic oesophagitis: high-dose proton pump inhibitors are required to rule out proton pump inhibitor-responsive eosinophilic oesophagitis; montelukast is not clearly effective in the treatment of eosinophilic oesophagitis, although moderate efficacy cannot be ruled out...
September 2016: Gastroenterología y Hepatología
https://www.readbyqxmd.com/read/27888219/long-term-intestinal-bleeding-in-a-child-a-rare-case-of-heterotopic-gastric-mucosa-in-the-jejunum
#19
Stella Leng, Marco Ghionzoli, Chiara Caporalini, Anna Maria Buccoliero
We report a rare case of heterotopic gastric mucosa presenting in a jejunal polyp of a 9-year-old girl, diagnosed with capsule endoscopy and laparoscopic exploration, after a 15-month history of lower gastrointestinal bleeding and anaemia. During surgery, the jejunal segment containing the polyp was resected and pathological examination revealed a polyp with gastric heterotopia. Heterotopic gastric mucosa is a rare pathology characterised by the presence of gastric mucosa outside of the stomach. Heterotopic gastric mucosa usually occurs in the oesophagus, duodenum, Meckel's diverticulum and enteric duplication cysts...
November 25, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27811857/phase-ii-study-of-chemoselection-with-docetaxel-plus-cisplatin-and-5-fluorouracil-induction-chemotherapy-and-subsequent-conversion-surgery-for-locally-advanced-unresectable-oesophageal-cancer
#20
MULTICENTER STUDY
Tomoya Yokota, Ken Kato, Yasuo Hamamoto, Yasuhiro Tsubosa, Hirofumi Ogawa, Yoshinori Ito, Hiroki Hara, Takashi Ura, Takashi Kojima, Keisho Chin, Shuichi Hironaka, Takayuki Kii, Yasushi Kojima, Yasunori Akutsu, Hisayuki Matsushita, Kentaro Kawakami, Keita Mori, Yushi Nagai, Chika Asami, Yuko Kitagawa
BACKGROUND: The standard treatment for locally advanced unresectable squamous cell carcinoma (SCC) of the oesophagus is chemoradiation with cisplatin and 5-fluorouracil (CF-RT). This multicentre phase II trial assessed the safety and efficacy of chemoselection with docetaxel plus cisplatin and 5-fluorouracil (DCF) induction chemotherapy (ICT) and subsequent conversion surgery (CS) for initially unresectable locally advanced SCC of the oesophagus. METHODS: Patients with clinical T4 and/or unresectable supraclavicular lymph node metastasis were eligible...
November 22, 2016: British Journal of Cancer
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