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lumbar degeneration in humans

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https://www.readbyqxmd.com/read/29770581/effect-of-static-compression-loads-on-intervertebral-disc-an-in-vivo-bent-rat-tail-model
#1
Wei Xia, Lin-Lin Zhang, Jun Mo, Wen Zhang, Hai-Tao Li, Zong-Ping Luo, Hui-Lin Yang
OBJECTIVE: To evaluate how well different magnitudes of compression-induced degenerative changes using a bent rat tail model simulated human lumbar lordosis. It has been shown that compression plays an important role in intervertebral disc degeneration (IDD). METHODS: Sprague-Dawley rats (n = 25) were instrumented with a special compressive apparatus that was used to bend the intervertebral disc between the 8th and the 10th caudal vertebral bodies using two Kirschner wires inserted percutaneously into the middle of two tail vertebrae...
May 16, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29673061/decellularization-and-characterization-of-a-whole-intervertebral-disc-xenograft-scaffold
#2
Austin Hensley, Jess Rames, Victor Casler, Christopher Rood, Joshua Walters, Christopher Fernandez, Sanjitpal Gill, Jeremy Mercuri
Intervertebral disc (IVD) degeneration is a multi-factor process that results in the physical destruction of the nucleus pulposus (NP) and annulus fibrosus (AF). This compromises IVD function and causes significant disability and economic burden. Strategies to replace the entire composite structure of the IVD are limited and most approaches do not recapitulate the heterogenous biochemical composition, micro-architecture or mechanical properties of the native tissue. Our central hypothesis was that donor IVDs which resemble the size and biochemistry of human lumbar IVDs could be successfully decellularized while retaining the tissue's structure and function with the long-term goal of creating a composite scaffold for tissue engineering the human IVD...
April 19, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29662769/human-and-bovine-spinal-disc-mechanics-subsequent-to-trypsin-injection
#3
Jeremy Alsup, Timothy Bishop, Dennis Eggett, Anton E Bowden
Objective: To investigate the biomechanical effects of injections of a protease on the characteristics of bovine coccygeal and human lumbar disc motion segments. Methods: Mechanics of treated tissues were measured immediately after injection and 3 h after injection. Motion segments underwent axial rotation and flexion-extension loading. Results: Stiffness and neutral zone parameters experienced significant changes over time, with bovine tissues more strongly affected than human cadaver tissues...
October 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29652862/inhibitory-effects-of-human-primary-intervertebral-disc-cells-on-human-primary-osteoblasts-in-a-co-culture-system
#4
Rahel D May, Daniela A Frauchiger, Christoph E Albers, Lorin M Benneker, Sandro Kohl, Benjamin Gantenbein
Spinal fusion is a common surgical procedure to address a range of spinal pathologies, like damaged or degenerated discs. After the removal of the intervertebral disc (IVD), a structural spacer is positioned followed by internal fixation, and fusion of the degenerated segment by natural bone growth. Due to their osteoinductive properties, bone morphogenetic proteins (BMP) are applied to promote spinal fusion. Although spinal fusion is successful in most patients, the rates of non-unions after lumbar spine fusion range from 5% to 35%...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617687/hemeoxygenase-1-suppresses-il-1%C3%AE-induced-apoptosis-through-the-nf-%C3%AE%C2%BAb-pathway-in-human-degenerative-nucleus-pulposus-cells
#5
Chaoying Zhu, Wei Jiang, Qiang Cheng, Zhenming Hu, Jie Hao
BACKGROUND/AIMS: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1 (HO-1) on human NPC apoptosis has never been reported. Our study aimed to investigate the effect and mechanism of HO-1 on apoptosis in human degenerative NPCs. METHODS: Nucleus pulposus tissues were collected from patients with lumbar vertebral fracture (LVF) and IDD...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29513014/rna-and-protein-interactors-with-tdp-43-in-human-spinal-cord-lysates-in-amyotrophic-lateral-sclerosis
#6
Kathryn Volkening, Brian A Keller, Cheryl Leystra-Lantz, Michael J Strong
The TAR DNA-binding protein of 43 kDa (TDP-43) is a dual function RNA- and DNA-binding protein with varied cellular functions. In degenerating motor neurons in amyotrophic lateral sclerosis (ALS), TDP-43 relocalizes from the nucleus to the cytosol, where it is sequestered into inclusions. It is likely that the pathogenic role of TDP-43 in ALS can involve either a gain or a loss of function, depending on the nature of its RNA or protein interactor. However, while TDP-43 binding partners have been identified in a range of model systems and from the human brain, interactors from human spinal-cord tissue have not...
April 6, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29442158/effects-of-human-parathyroid-hormone-1-34-on-bone-loss-and-lumbar-intervertebral-disc-degeneration-in-ovariectomized-rats
#7
Yang Luo, Shu-Yang Li, Fa-Ming Tian, Hui-Ping Song, Ying-Ze Zhang, Liu Zhang
PURPOSE: Lumbar intervertebral disc degeneration is a common cause of lower back pain that affects the physical and mental health of patients and increases social burden. Parathyroid hormone has been reported to be effective at inhibiting disc degeneration; however, these effects have not been fully established in vivo in ovariectomized (OVX) rats. Thus, in this study, we aimed to address this issue and examine the effects of parathyroid hormone treatment in OVX rats. METHODS: Thirty female Sprague-Dawley rats, three months-old, were subjected to sham or ovariectomy surgery...
May 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29436660/cartilage-intermediate-layer-protein-is-regulated-by-mechanical-stress-and-affects-extracellular-matrix-synthesis
#8
Jinyue He, Chencheng Feng, Jing Sun, Kang Lu, Tongwei Chu, Yue Zhou, Yong Pan
Lumbar disc disease (LDD) is common in aged populations, and it is primarily caused by intervertebral disc degeneration (IDD). Cartilage intermediate layer protein (CILP), which is specifically expressed in intervertebral discs (IVDs), is suspected to be associated with IDD. However, it remains unclear whether CILP contributes to IDD in humans. Furthermore, the regulation of CILP in human IVDs is poorly understood, especially by mechanical stimuli, which are regarded as primary factors promoting IDD. To address these issues, the present study collected nucleus pulposus (NP) cells from patients undergoing lumbar spinal surgery for degenerative disc disease (DDD)...
April 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29436145/accumulated-spinal-axial-biomechanical-loading-induces-degeneration-in-intervertebral-disc-of-mice-lumbar-spine
#9
Yang-Jun Lao, Tao-Tao Xu, Hong-Ting Jin, Hong-Feng Ruan, Ji-Tao Wang, Li Zhou, Ping-Er Wang, Jian Wang, Jun Ying, Yuan-Bin Zhang, Cheng Luo, Fang-da Fu, Pei-Jian Tong, Lu-Wei Xiao, Cheng-Liang Wu
OBJECTIVE: To investigate the effect of accumulated spinal axial biomechanical loading on mice lumbar disc and the feasibility of applying this method to establish a mice intervertebral disc degeneration model using a custom-made hot plate cage. In previous studies, we observed that the motion pattern of mice was greatly similar to that of humans when they were standing and jumping on their lower limbs. There is little data to demonstrate whether or not accumulated spinal axial biomechanical loading could induce intervertebral disc degeneration in vivo...
February 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29434746/role-of-mir-589-3p-in-human-lumbar-disc-degeneration-and-its-potential-mechanism
#10
Aiqing Lu, Zhirong Wang, Suchun Wang
The present study aimed to investigate the role of miR-589-3p in lumbar disc degeneration (LDD) and to explore the underlying mechanisms. Nucleus pulposus (NP) cells were stimulated with lipopolysaccharide (LPS) to simulate an in vitro model of intervertebral disc degeneration. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to detect the expression level of microRNA (miR)-589-3p in the NP cells, and the results demonstrated that the increased expression of miR-589-3p in LPS stimulated NP cells compared with the control...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29431237/contribution-of-facet-joints-axial-compression-and-composition-to-human-lumbar-disc-torsion-mechanics
#11
Semih E Bezci, Ananth Eleswarapu, Eric O Klineberg, Grace D O'Connell
Stresses applied to the spinal column are distributed between the intervertebral disc and facet joints. Structural and compositional changes alter stress distributions within the disc and between the disc and facet joints. These changes influence the mechanical properties of the disc joint, including its stiffness, range of motion, and energy absorption under quasi-static and dynamic loads. There have been few studies evaluating the role of facet joints in torsion. Furthermore, the relationship between biochemical composition and torsion mechanics is not well understood...
February 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29407350/in-vivo-study-of-paraspinal-muscle-weakness-using-botulinum-toxin-in-one-primate-model
#12
Sang Kuy Han, Youngjeon Lee, Jung-Joo Hong, Hyeon-Gu Yeo, Jincheol Seo, Chang-Yeop Jeon, Kang-Jin Jeong, Yeung Bae Jin, Philyong Kang, Sangil Lee, Choongsoo S Shin, Young Eun Kim, Keyoung Jin Chun, Kyu-Tae Chang, Sang-Rae Lee
BACKGROUND: It has been generally speculated that paraspinal muscle weakness is related to the spinal degeneration including intervertebral disc failure. The purpose of this study was to investigate the effects of paraspinal muscle weakness induced by the botulinum toxin type-A on the lumbar spine and behavior pattern in an in-vivo primate model which has an upright locomotion similar to that of humans. METHODS: Botox injections into paraspinal muscle of one cynomolgus monkey were conducted biweekly up to 19 weeks at L2-L3, L3-L4 and L4-L5...
March 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29397109/adaptation-of-a-clinical-fixation-device-for-biomechanical-testing-of-the-lumbar-spine
#13
Kevin M Bell, Adrianna Oh, Harold A Cook, Yiguo Yan, Joon Y Lee
In-vitro biomechanical testing is widely performed for characterizing the load-displacement characteristics of intact, injured, degenerated, and surgically repaired osteoligamentous spine specimens. Traditional specimen fixture devices offer an unspecified rigidity of fixation, while varying in the associated amounts and reversibility of damage to and "coverage" of a specimen - factors that can limit surgical access to structures of interest during testing as well as preclude the possibility of testing certain segments of a specimen...
March 1, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29353774/temporal-and-spatial-variations-of-pressure-within-intervertebral-disc-nuclei
#14
Hendrik Schmidt, Aboulfazl Shirazi-Adl
Experimental and computational studies often presume that nuclei pulposi of non-degenerated human lumbar discs function as fluid-filled cavities with single hydrostatic pressures throughout that vary neither with time nor location and orientation. Recent simultaneous measurements of the pressure at multiple locations within disc nuclei have however shown time-dependent and nonhomogeneous pressure distributions. This combined in vitro and in silico study aims to re-examine the temporal and spatial variations of the pressure within disc nuclei with special focus on the effect of tissue hydration...
March 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29316495/vdr-and-gc-gene-polymorphisms-modulate-the-risk-of-lumbar-disc-degeneration-in-iran
#15
Sohail Mashayekhi, Alia Saberi, Zivar Salehi, Gelareh Biazar, Roghayeh Mehrdel
OBJECTIVE: Lumbar disc degeneration (LDD) occurs commonly in humans. Vitamin D metabolic and signaling pathway plays a significant role in intervertebral disc degeneration. The aim of this study was to evaluate the influence of the genetic polymorphism in the two key genes of 1,25-(OH)2 -D3 pathway, VDR (vitamin D receptor) and GC (group-specific component), in LDD development. PATIENTS AND METHODS: Two single-nucleotide polymorphisms, VDR rs2228570 (FokI) and GC rs7041, were genotyped in 180 patients with LDD and 230 healthy individuals...
February 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29315127/tidemark-avulsions-are-a-predominant-form-of-endplate-irregularity
#16
Britta Berg-Johansen, Deeptee Jain, Ellen C Liebenberg, Aaron J Fields, Thomas M Link, Conor W O'Neill, Jeffrey C Lotz
STUDY DESIGN: Descriptive histologic and MRI study of human cadaveric spines. OBJECTIVE: To identify and characterize common endplate pathologies to form a histologic foundation for an etiology-based classification system. SUMMARY OF BACKGROUND DATA: Irregularities at the spinal disc-vertebra interface are associated with back pain and intervertebral disc herniation injuries. However, there is currently a lack of consensus regarding terminology for classification...
January 8, 2018: Spine
https://www.readbyqxmd.com/read/29259641/icariin-prevents-il-1-%C3%AE-induced-apoptosis-in-human-nucleus-pulposus-via-the-pi3k-akt-pathway
#17
Xiangyu Deng, Wei Wu, Hang Liang, Donghua Huang, Doudou Jing, Dong Zheng, Zengwu Shao
Purpose: To explore the effect and possible mechanism of icariin, a prenylated flavonol glycoside derived from the Chinese herb Epimedium sagittatum that was applied to IL-1 β pretreated human nucleus pulposus (NP) cells. Methods: Human NP cells were isolated from intervertebral discs of patients with scoliosis and lumbar spondylolisthesis. The cells were divided into five groups: A (blank control); B (20 ng/ml IL-1 β ); C (20 ng/ml IL-1 β + 20  μ M icariin); D (20  μ M icariin + 20 ng/ml IL-1 β + 25  μ M LY294002); E (20 ng/ml IL-1 β + 25  μ M LY294002)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29259166/inhibition-of-autophagy-delays-motoneuron-degeneration-and-extends-lifespan-in-a-mouse-model-of-spinal-muscular-atrophy
#18
Antonio Piras, Lorenzo Schiaffino, Marina Boido, Valeria Valsecchi, Michela Guglielmotto, Elena De Amicis, Julien Puyal, Ana Garcera, Elena Tamagno, Rosa M Soler, Alessandro Vercelli
Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease, due to homozygous mutations or deletions in the telomeric survival motoneuron gene 1 (SMN1). SMA is characterized by motor impairment, muscle atrophy, and premature death following motor neuron (MN) degeneration. Emerging evidence suggests that dysregulation of autophagy contributes to MN degeneration. We here investigated the role of autophagy in the SMNdelta7 mouse model of SMA II (intermediate form of the disease) which leads to motor impairment by postnatal day 5 (P5) and to death by P13...
December 20, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29221904/tensile-behaviour-of-individual-fibre-bundles-in-the-human-lumbar-anulus-fibrosus
#19
Diana T Pham, Joe G Shapter, John J Costi
Disc degeneration is a common medical affliction whose origins are not fully understood. An improved understanding of its underlying mechanisms could lead to the development of more effective treatments. The aim of this paper was to investigate the effect of (1) degeneration, (2) circumferential region and (3) strain rate on the microscale mechanical properties (toe region modulus, linear modulus, extensibility, phase angle) of individual fibre bundles in the anulus fibrosus lamellae of the human intervertebral disc...
January 23, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29204735/inflammaging-in-cervical-and-lumbar-degenerated-intervertebral-discs-analysis-of-proinflammatory-cytokine-and-trp-channel-expression
#20
Aleksandra Sadowska, Ermioni Touli, Wolfgang Hitzl, Helen Greutert, Stephen J Ferguson, Karin Wuertz-Kozak, Oliver N Hausmann
PURPOSE: To investigate and compare the occurrence of inflammatory processes in the sites of disc degeneration in the lumbar and cervical spine by a gene array and subsequent qPCR and to investigate the mechanistic involvement of transient receptor potential channels TRPC6 and TRPV4. METHODS: The gene expression of inflammatory cytokines and TRP channels was measured in human disc samples obtained from patients undergoing discectomy at the cervical (n = 24) or lumbar (n = 27) spine for degenerative disc disease (DDD) and disc herniation (DH) and analyzed for differences with regard to spinal level, IVD degeneration grade, Modic grade, age, sex, disc region and surgical extent...
March 2018: European Spine Journal
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