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https://www.readbyqxmd.com/read/28430330/long-term-visual-outcomes-in-children-with-primary-congenital-glaucoma
#1
Sanaa A Yassin
PURPOSE: To determine the long-term visual outcomes and risk factors for visual loss in children with primary congenital glaucoma (PCG) who underwent angle surgery over a 21-year period. METHODS: This was a retrospective study of patients who underwent trabeculotomy, trabeculectomy, or combined trabeculotomy-trabeculectomy for PCG. Visual acuity (VA), surgeries, and underlying cause of visual impairment were recorded and compared. Main outcome measures were final best-corrected good VA (20/20 to 20/50), moderate VA (<20/50 to 20/200), or poor VA (<20/200); age at surgery, sex, laterality, type of initial glaucoma surgery, and number of surgeries were recorded...
April 20, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28415122/p1138cardiac-shear-wave-velocity-in-healthy-individuals
#2
M Strachinaru, M L Geleijnse, J G Bosch, N De Jong, Afw Van Der Steen, B M Van Dalen, H J Vos
Background: The closure of the valves generates shear waves in the heart walls. The propagation velocity of shear waves relates to stiffness. This could potentially be used to estimate the stiffness of the myocardium, with huge potential implications in pathologies characterized by a deterioration of the diastolic properties of the left ventricle. In an earlier phantom study we already validated shear wave tracking with a clinical ultrasound system in cardiac mode. Purpose: In this study we aimed to measure the shear waves velocity in normal individuals...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28410136/directed-connectivity-of-brain-default-networks-in-resting-state-using-gca-and-motif
#3
Zhuqing Jiao, Huan Wang, Kai Ma, Ling Zou, Jianbo Xiang
Nowadays, there is a lot of interest in assessing functional interactions between key brain regions. In this paper, Granger causality analysis (GCA) and motif structure are adopted to study directed connectivity of brain default mode networks (DMNs) in resting state. Firstly, the time series of functional magnetic resonance imaging (fMRI) data in resting state were extracted, and the causal relationship values of the nodes representing related brain regions are analyzed in time domain to construct a default network...
June 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28394339/nspc1-promotes-cancer-stem-cell-self-renewal-by-repressing-the-synthesis-of-all-trans-retinoic-acid-via-targeting-rdh16-in-malignant-glioma
#4
P-S Hu, Q-S Xia, F Wu, D-K Li, Y-J Qi, Y Hu, Z-Z Wei, S-S Li, N-Y Tian, Q-F Wei, L-J Shen, B Yin, T Jiang, J-G Yuan, B-Q Qiang, W Han, X-Z Peng
Polycomb group (PcG) proteins play an important role in development and stem cell maintenance, and their dysregulation have been closely linked to oncogenesis and cancer stem cell phenotypes. Here, we found that nervous system polycomb 1 (NSPc1) was highly expressed in stem cell-like glioma cells (SLCs). Knockdown of NSPc1 in SLCs resulted in impaired neurosphere formation and self-renewal abilities, down-regulated expression of stemness markers such as NESTIN, CD133 and SOX2, and decreased capacity to propagate subcutaneous xenografts...
April 10, 2017: Oncogene
https://www.readbyqxmd.com/read/28386709/in-silico-analysis-of-five-missense-mutations-in-cyp1b1-gene-in-pakistani-families-affected-with-primary-congenital-glaucoma
#5
Sabika Firasat, Haiba Kaul, Usman Ali Ashfaq, Sobia Idrees
PURPOSE: The purpose of this study was to characterize the five missense mutations in CYP1B1 gene identified in Pakistani families affected with primary congenital glaucoma (PCG) using various bioinformatics and protein modeling tools. METHODS: We previously reported four novel missense mutations in CYP1B1 gene segregating in consanguineous Pakistani families. These mutations were identified by direct sequencing of all coding exons, the exon-intron boundaries and the 5' untranslated region of CYP1B1 using genomic DNA from affected and unaffected family members...
April 6, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28384041/candidate-gene-analysis-identifies-mutations-in-cyp1b1-and-ltbp2-in-indian-families-with-primary-congenital-glaucoma
#6
Yeming Yang, Lin Zhang, Shujin Li, Xianjun Zhu, Periasamy Sundaresan
BACKGROUND: Primary congenital glaucoma (PCG) is a severe ocular disorder that presents early in life. Cytochrome P4501B1 (CYP1B1) and latent transforming growth factor-beta-binding protein 2 (LTBP2) are the most commonly mutated genes in PCG. AIM: To investigate the causative genetic mutations in eight Indian families with PCG. MATERIALS AND METHODS: Whole-exome sequencing was applied to analyze the genomic DNA samples from PCG probands. Sanger sequencing was utilized to confirm the identified mutations...
April 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28381411/dual-functionality-of-cis-regulatory-elements-as-developmental-enhancers-and-polycomb-response-elements
#7
Jelena Erceg, Tibor Pakozdi, Raquel Marco-Ferreres, Yad Ghavi-Helm, Charles Girardot, Adrian P Bracken, Eileen E M Furlong
Developmental gene expression is tightly regulated through enhancer elements, which initiate dynamic spatio-temporal expression, and Polycomb response elements (PREs), which maintain stable gene silencing. These two cis-regulatory functions are thought to operate through distinct dedicated elements. By examining the occupancy of the Drosophila pleiohomeotic repressive complex (PhoRC) during embryogenesis, we revealed extensive co-occupancy at developmental enhancers. Using an established in vivo assay for PRE activity, we demonstrated that a subset of characterized developmental enhancers can function as PREs, silencing transcription in a Polycomb-dependent manner...
March 15, 2017: Genes & Development
https://www.readbyqxmd.com/read/28380363/polycomb-and-hox-genes-control-jnk-induced-remodeling-of-the-segment-boundary-during-drosophila-morphogenesis
#8
Solange Roumengous, Raphaël Rousset, Stéphane Noselli
In segmented tissues, anterior and posterior compartments represent independent morphogenetic domains, which are made of distinct lineages separated by boundaries. During dorsal closure of the Drosophila embryo, specific "mixer cells" (MCs) are reprogrammed in a JNK-dependent manner to express the posterior determinant engrailed (en) and cross the segment boundary. Here, we show that JNK signaling induces de novo expression of en in the MCs through repression of Polycomb (Pc) and release of the en locus from the silencing PcG bodies...
April 4, 2017: Cell Reports
https://www.readbyqxmd.com/read/28346469/computational-identifying-and-characterizing-circular-rnas-and-their-associated-genes-in-hepatocellular-carcinoma
#9
Yan Li, Yongcheng Dong, Ziyan Huang, Qifan Kuang, Yiming Wu, Yizhou Li, Menglong Li
Hepatocellular carcinoma (HCC) is currently still a major factor leading to death, lacking of reliable biomarkers. Therefore, deep understanding the pathogenesis for HCC is of great importance. The emergence of circular RNA (circRNA) provides a new way to study the pathogenesis of human disease. Here, we employed the prediction tool to identify circRNAs based on RNA-seq data. Then, to investigate the biological function of the circRNA, the candidate circRNAs were associated with the protein-coding genes (PCGs) by GREAT...
2017: PloS One
https://www.readbyqxmd.com/read/28345568/prognosis-of-different-glaucomas-seen-at-a-tertiary-center-a-10-year-overview
#10
Ramanjit Sihota, Neha Midha, Harathy Selvan, Talvir Sidhu, Deepa R Swamy, Ajay Sharma, Amisha Gupta, Viney Gupta, Tanuj Dada, Sunil Chaudhary
AIM: This study aims to determine treatment patterns, long-term intraocular pressure (IOP) and perimetric control in different glaucomas seen at a tertiary eye center. SETTINGS AND DESIGN: Hospital-based, cross-sectional chart review of patients routinely following up at an outpatient glaucoma service. METHODS: Patients with a follow-up of at least 10 years were evaluated. Their mean IOP, visual field (VF) status, and medications/surgery required at final assessment were noted...
February 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28337857/wxc-c-nrgo-composite-derived-from-polyoxotungstate-conductive-polypyrrole-graphene-as-efficient-electrocatalyst-for-hydrogen-evolution-reaction
#11
Ya-Qian Lan, Xiao-Li Wang, Yu-Jia Tang, Wei Huang, Chun-Hui Liu, Long-Zhang Dong, Shun-Li Li
Efficient hydrogen evolution reaction (HER) from water through electrocatalysis using cost-effective materials is critical to realize the clean hydrogen production. Herein, with controlling the structure and composition of polyoxotungstate/conductive polypyrrole/graphene (PCG) precursor precisely and followed by the temperature-programmed reaction, we developed a highly active and stable catalyst WxC@C/NRGO. The composite presents splendid performance towards HER in acidic media, with a small onset overpotential of 24 mV vs...
March 23, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28335471/mobile-phonocardiogram-diagnosis-in-newborns-using-support-vector-machine
#12
Amir Mohammad Amiri, Mohammadreza Abtahi, Nick Constant, Kunal Mankodiya
Phonocardiogram (PCG) monitoring on newborns is one of the most important and challenging tasks in the heart assessment in the early ages of life. In this paper, we present a novel approach for cardiac monitoring applied in PCG data. This basic system coupled with denoising, segmentation, cardiac cycle selection and classification of heart sound can be used widely for a large number of the data. This paper describes the problems and additional advantages of the PCG method including the possibility of recording heart sound at home, removing unwanted noises and data reduction on a mobile device, and an intelligent system to diagnose heart diseases on the cloud server...
March 18, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28330355/fast-divide-and-conquer-algorithm-for-evaluating-polarization-in-classical-force-fields
#13
Dominique Nocito, Gregory J O Beran
Evaluation of the self-consistent polarization energy forms a major computational bottleneck in polarizable force fields. In large systems, the linear polarization equations are typically solved iteratively with techniques based on Jacobi iterations (JI) or preconditioned conjugate gradients (PCG). Two new variants of JI are proposed here that exploit domain decomposition to accelerate the convergence of the induced dipoles. The first, divide-and-conquer JI (DC-JI), is a block Jacobi algorithm which solves the polarization equations within non-overlapping sub-clusters of atoms directly via Cholesky decomposition, and iterates to capture interactions between sub-clusters...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28329686/demethylated-hsatii-dna-and-hsatii-rna-foci-sequester-prc1-and-mecp2-into-cancer-specific-nuclear-bodies
#14
Lisa L Hall, Meg Byron, Dawn M Carone, Troy W Whitfield, Gayle P Pouliot, Andrew Fischer, Peter Jones, Jeanne B Lawrence
This study reveals that high-copy satellite II (HSATII) sequences in the human genome can bind and impact distribution of chromatin regulatory proteins and that this goes awry in cancer. In many cancers, master regulatory proteins form two types of cancer-specific nuclear bodies, caused by locus-specific deregulation of HSATII. DNA demethylation at the 1q12 mega-satellite, common in cancer, causes PRC1 aggregation into prominent Cancer-Associated Polycomb (CAP) bodies. These loci remain silent, whereas HSATII loci with reduced PRC1 become derepressed, reflecting imbalanced distribution of UbH2A on these and other PcG-regulated loci...
March 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/28303357/long-term-surgical-outcome-of-conventional-trabeculotomy-for-childhood-glaucoma
#15
Hiroko Ozawa, Mio Yamane, Eisuke Inoue, Tomoyo Yoshida-Uemura, Satoshi Katagiri, Tadashi Yokoi, Sachiko Nishina, Noriyuki Azuma
PURPOSE: To investigate the long-term surgical outcomes of conventional trabeculotomy in eyes with childhood glaucoma in a Japanese population. METHODS: In this retrospective observational study, we enrolled Japanese patients with childhood glaucoma who underwent a conventional trabeculotomy at least once before age 3 years from 1986 to 2014 in our hospital. RESULTS: One hundred seven eyes of 64 patients (24 girls, 40 boys; mean age, 2.8 ± 5...
March 16, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28282485/contribution-of-mutations-in-known-mendelian-glaucoma-genes-to-advanced-early-onset-primary-open-angle-glaucoma
#16
Tiger Zhou, Emmanuelle Souzeau, Owen M Siggs, John Landers, Richard Mills, Ivan Goldberg, Paul R Healey, Stuart Graham, Alex W Hewitt, David A Mackey, Anna Galanopoulos, Robert J Casson, Jonathan B Ruddle, Jonathan Ellis, Paul Leo, Matthew A Brown, Stuart MacGregor, Shiwani Sharma, Kathryn P Burdon, Jamie E Craig
Purpose: Primary open-angle glaucoma (POAG) and primary congenital glaucoma (PCG) with Mendelian inheritance are caused by mutations in at least nine genes. Utilizing whole-exome sequencing, we examined the disease burden accounted for by these known Mendelian glaucoma genes in a cohort of individuals with advanced early-onset POAG. Methods: The cases exhibited advanced POAG with young age of diagnosis. Cases and examined local controls were subjected to whole-exome sequencing...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28271953/injectable-and-biodegradable-temperature-responsive-mixed-polymer-systems-providing-variable-gel-forming-ph-regions
#17
Yasuyuki Yoshida, Keisuke Kawahara, Shintaro Mitsumune, Akinori Kuzuya, Yuichi Ohya
Aqueous solutions of biodegradable polymers exhibiting sol-to-gel transitions in response to external stimuli such as temperature and pH are expected to be used as injectable polymers (IPs) for biomedical applications. In this study, we prepared novel biodegradable temperature-responsive IP systems providing variable gel-forming pH regions. We synthesized PCGA-b-PEG-b-PCGA (tri-PCG) and attached carboxylic acid or primary amine groups on both termini, tri-PCG-COOH and tri-PCG-NH2, and investigated the temperature-responsive sol-to-gel transition behavior of the mixtures of these two copolymers at various pHs...
March 8, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28269674/classification-of-severity-of-mitral-regurgitation-patients-using-multifractal-analysis
#18
Rijil Thomas, Ling Lieng Hsi, Soh Cheong Boon, Erry Gunawan
Owing to its efficiency and cost effectiveness, auscultation using a stethoscope is the primary diagnosis method preferred by most medical examiners for cardiovascular disease. Phonocardiography (PCG) is the next level of auscultation and an effective analysis technique in cardiology. This paper presents a method to quantify Mitral Regurgitation (MR) using PCG. MR is one of the most common cardiovascular diseases associated with a defect in mitral valve. We analyzed the multifractal nature of heart sounds with murmur followed by classification and clustering using Hurst exponents...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28236618/common-1h-mrs-characteristics-in-patients-with-alzheimer-s-disease-and-vascular-dementia-diagnosed-with-kidney-essence-deficiency-syndrome-a-preliminary-study
#19
Zhongwei Guo, Xiaozheng Liu, Yulin Cao, Hongtao Hou, Xingli Chen, Yongcan Chen, Feihua Huang, Wei Chen
Context • Traditional Chinese medicine (TCM) indicates that both Alzheimer's disease (AD) and vascular dementia (VD) should be categorized as dementia and that they have a common etiology and pathogenesis under TCM classification of syndromes, such as with kidney essence deficiency syndrome (KEDS). The pathological location is mainly in the brain. However, it remains unclear whether AD and VD patients with KEDS exhibit a metabolic commonality in the same region of the brain. Objective • The study intended to investigate the metabolic characteristics of the brain using proton magnetic resonance spectroscopy (1H-MRS) in patients with AD and VD who had been diagnosed with KEDS...
February 27, 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28236166/alteration-of-regional-homogeneity-and-white-matter-hyperintensities-in-amnestic-mild-cognitive-impairment-subtypes-are-related-to-cognition-and-csf-biomarkers
#20
Xiao Luo, Yerfan Jiaerken, Peiyu Huang, Xiao Jun Xu, Tiantian Qiu, Yunlu Jia, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Minming Zhang
Amnestic mild cognitive impairment can be further classified as single-domain aMCI (SD-aMCI) with isolated memory deficit, or multi-domain aMCI (MD-aMCI) if memory deficit is combined with impairment in other cognitive domains. Prior studies reported these clinical subtypes presumably differ in etiology. Thus, we aimed to explore the possible mechanisms between different aMCI subtypes by assessing alteration in brain activity and brain vasculature, and their relations with CSF AD biomarkers. 49 healthy controls, 32 SD-aMCI, and 32 MD-aMCI, who had undergone structural scans, resting-state functional MRI (rsfMRI) scans and neuropsychological evaluations, were identified...
February 24, 2017: Brain Imaging and Behavior
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