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Spinal nerve ligation

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https://www.readbyqxmd.com/read/29318854/-effect-of-electroacupuncture-on-intracellular-calcium-ion-concentration-and-expression-of-calcium-calmodulin-dependent-protein-kinase-%C3%A2-in-lumbar-spinal-cord-in-rats-with-neuropathic-pain
#1
Xin-Tian Wu, Wei Liang, Li-Ping Yan, Ling-Ling Wang, Cheng Ma
OBJECTIVE: To observe the changes of intracellular calcium ([Ca2+]i) concentration and expression of calcium/calmodulin dependent protein kinaseⅡ (CaMKⅡ) in spinal dorsal horn neurons of spared nerve injury (SNI) rats, so as to explore its mechanisms underlying improvement of neuropathic pain. METHODS: One hundred and ten SD rats were randomly divided into 5 groups: sham control, model, EA, AP-5 and L-NAME groups. The sham group underwent only a simple separation of the sciatic nerve but without ligation and abscission...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29258553/prenatal-alcohol-exposure-is-a-risk-factor-for-adult-neuropathic-pain-via-aberrant-neuroimmune-function
#2
Joshua J Sanchez, Shahani Noor, Suzy Davies, Daniel Savage, Erin D Milligan
BACKGROUND: Clinical studies show that prenatal alcohol exposure (PAE) results in effects that persist into adulthood. Experimental animal models of moderate PAE demonstrate that young adults with PAE display potentiated sensitivity to light touch, clinically termed allodynia, following sciatic nerve chronic constriction injury (CCI) that coincides with heightened spinal glial, spinal macrophage, and peripheral immune responses. However, basal touch sensitivity and corresponding glial and leukocyte activation are unaltered...
December 19, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29215727/secreted-frizzled-related-protein-1-regulates-the-progression-of-neuropathic-pain-in-mice-following-spinal-nerve-ligation
#3
Jun Tang, Qing Ji, Li Jin, Mi Tian, Li Dong Zhang, Xiao Yu Liu
Previous studies have showed that the Wnt/β-catenin signaling pathway plays an important role in modulating neuropathic pain after sciatic nerve injury. In this study, we explored the role of secreted frizzled-related protein 1 (SFRP1), a Wnt antagonist, in neuropathic pain using a rat model following spinal nerve ligation (SNL). We found SNL-induced SFRP1 downregulation in the spinal cord. Further, the overexpression of SFRP1 via spinal injection into the spinal cord attenuated SNL-induced allodynia, hyperalgesia and neuroinflammation...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29190962/wu-tou-decoction-attenuates-neuropathic-pain-via-suppressing-spinal-astrocytic-il-1r1-traf6-jnk-signaling
#4
Chao Wang, Xiangying Kong, Chunyan Zhu, Chunfang Liu, Danni Sun, Qionghong Xu, Zhiyun Mao, Qingxia Qin, Hongchang Su, Danqiao Wang, Xiaoliang Zhao, Na Lin
Neuropathic pain (NP) caused by nerve injuries continues to be an intractable challenge due to inadequate therapeutic strategies. Recent study demonstrated glia-induced neuro-inflammation in the spinal cord, especially the activation of astrocytes, plays an essential role in the development of NP, which opens new avenues for NP treatment. In this study, we explored the anti-hyperalgesia properties of Wu-tou decoction (WTD) and showed that WTD potently attenuates mechanical allodynia and heat hyperalgesia in lumbar 5 (L5) spinal nerve ligation (SNL)-induced NP without noticeable side effect or affecting basal pain perception of mice...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29180893/identification-of-key-genes-and-pathways-associated-with-neuropathic-pain-in-uninjured-dorsal-root-ganglion-by-using-bioinformatic-analysis
#5
Chao-Jin Chen, De-Zhao Liu, Wei-Feng Yao, Yu Gu, Fei Huang, Zi-Qing Hei, Xiang Li
Purpose: Neuropathic pain is a complex chronic condition occurring post-nervous system damage. The transcriptional reprogramming of injured dorsal root ganglia (DRGs) drives neuropathic pain. However, few comparative analyses using high-throughput platforms have investigated uninjured DRG in neuropathic pain, and potential interactions among differentially expressed genes (DEGs) and pathways were not taken into consideration. The aim of this study was to identify changes in genes and pathways associated with neuropathic pain in uninjured L4 DRG after L5 spinal nerve ligation (SNL) by using bioinformatic analysis...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29178358/conventional-scs-vs-burst-scs-and-the-behavioral-effect-on-mechanical-hypersensitivity-in-a-rat-model-of-chronic-neuropathic-pain-effect-of-amplitude
#6
Koen P V Meuwissen, Jianwen Wendy Gu, Tianhe C Zhang, Elbert A J Joosten
OBJECTIVE: Various spinal cord stimulation (SCS) modes are used in the treatment of chronic neuropathic pain disorders. Conventional (Con) and Burst-SCS are hypothesized to exert analgesic effects through different stimulation-induced mechanisms. Preclinical electrophysiological findings suggest that stimulation intensity is correlated with the effectiveness of Burst-SCS. Therefore, we aimed to investigate the relation between amplitude (charge per second) and behavioral effects in a rat model of chronic neuropathic pain, for both Conventional Spinal Cord Stimulation (Con-SCS) and biphasic Burst-SCS...
November 27, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29170626/role-of-microrna-143-in-nerve-injury-induced-upregulation-of-dnmt3a-expression-in-primary-sensory-neurons
#7
Bo Xu, Jing Cao, Jun Zhang, Shushan Jia, Shaogen Wu, Kai Mo, Guihua Wei, Lingli Liang, Xuerong Miao, Alex Bekker, Yuan-Xiang Tao
Peripheral nerve injury increased the expression of the DNA methyltransferase 3A (Dnmt3a) mRNA and its encoding Dnmt3a protein in injured dorsal root ganglia (DRG). This increase is considered as an endogenous instigator in neuropathic pain genesis through epigenetic silencing of pain-associated genes (such as Oprm1) in injured DRG. However, how DRG DNMT3a is increased following peripheral nerve injury is still elusive. We reported here that peripheral nerve injury caused by the fifth spinal nerve ligation (SNL) downregulated microRNA (miR)-143 expression in injured DRG...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29115575/microrna-142-3p-relieves-neuropathic-pain-by-targeting-high-mobility-group-box-1
#8
Yang Zhang, Junying Mou, Li Cao, Su Zhen, Hongjuan Huang, Hongguang Bao
MicroRNA (miRNA) are emerging as critical regulators of neuropathic pain development. Neuroinflammation contributes to the development of neuropathic pain. miR‑142‑3p has been characterized as an inflammation‑related miRNA in various pathological processes. However, little is known about the role of miR‑142‑3p in neuroinflammation and neuropathic pain. The present study aimed to investigate the function of miR‑142‑3p in neuropathic pain by creating a murine model using spinal nerve ligation (SNL)...
October 27, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29108992/mir-32-5p-mediated-dusp5-downregulation-contributes-to-neuropathic-pain
#9
Tingfei Yan, Fuguo Zhang, Chenxi Sun, Jingchuan Sun, Yuan Wang, Ximing Xu, Jiangang Shi, Guodong Shi
Previous studies have demonstrated that microRNAs (miRNAs) play important roles in the pathogenesis of neuropathic pain. In the present study, we found that miR-32-5p was significantly upregulated in rats after spinal nerve ligation (SNL), specifically in the spinal microglia of rats with SNL. Functional assays showed that knockdown of miR-32-5p greatly suppressed mechanical allodynia and heat hyperalgesia, and decreased inflammatory cytokine (IL-1β, TNF-α and IL-6) protein expression in rats after SNL. Similarly, miR-32-5p knockdown alleviated cytokine production in lipopolysaccharide (LPS)-treated spinal microglial cells, whereas its overexpression had the opposite effect...
November 3, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29105869/downregulation-of-spinal-astrocytic-connexin43-leads-to-upregulation-of-interleukin-6-and-cyclooxygenase-2-and-mechanical-hypersensitivity-in-mice
#10
Norimitsu Morioka, Shiori Fujii, Syun Kondo, Fang Fang Zhang, Kazuki Miyauchi, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata
Connexin43 (Cx43), involved in intercellular signaling, is expressed in spinal dorsal horn astrocytes and crucial in the maintenance of neuropathic pain. Downregulation of spinal astrocytic Cx43 in mice enhances glutamatergic neurotransmission by decreasing glutamate transporter GLT-1 expression, resulting in cutaneous hypersensitivity. Decreased expression of astrocytic Cx43 could lead to altered expression of other nociceptive molecules. Transfection of Cx43-targeting siRNA in cultured spinal astrocytes increased expression of the pronociceptive cytokine interleukin-6 (IL-6) and the prostaglandin synthesizing enzyme cyclooxygenase-2 (COX-2)...
February 2018: Glia
https://www.readbyqxmd.com/read/29089890/long-chain-omega-3-fatty-acids-supplementation-accelerates-nerve-regeneration-and-prevents-neuropathic-pain-behavior-in-mice
#11
Rafaela V Silva, Julia T Oliveira, Bruna L R Santos, Fabiana C Dias, Ana M B Martinez, Cleverton K F Lima, Ana L P Miranda
Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allodynia and hyperalgesia. We tested the preventive effect of an EPA/DHA-concentrate fish oil (CFO) on NP development and regenerative features. Swiss mice received daily oral treatment with CFO 4...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29079432/peripheral-nerve-injury-induced-rearrangement-of-neural-circuit-in-the-spinal-dorsal-horn-revealed-by-cross-correlation-analysis
#12
Yu Takemura, Shunsaku Kobayashi, Eiko Kato, Shigeki Yamaguchi, Yuuichi Hori
Peripheral nerve injury often induces abnormal pain states, such as hyperalgesia and allodynia. In this study, we attempted to elucidate how neurons are synaptically integrated into the neuronal circuitry in the spinal dorsal horn and how synaptic connectivity patterns among dorsal horn neurons are altered by peripheral nerve injury. Experiments were performed on 6-8-week-old ICR mice. Partial sciatic nerve ligation was performed. Transverse slices of the lumbar spinal cord were prepared. Spike activities were simultaneously recorded from multiple neurons in the superficial dorsal horn (SDH) using a multi-electrode array system, and cross-correlograms between spike trains of neuron pairs were constructed...
October 24, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29037948/discovery-of-aminocyclohexene-analogues-as-selective-and-orally-bioavailable-hnav1-7-inhibitors-for-analgesia
#13
Mingxing Teng, Wentao Wu, Zhixiang Li, Guangwen Yang, Jian Qin, Yikai Wang, Zhijing Hu, Haiheng Dong, Lijuan Hou, Guoping Hu, Liang Shen, Yang Zhang, Jian Li, Shuhui Chen, Jingwei Tian, Liang Ye, Jianzhao Zhang, Hongbo Wang
hNav1.7 receives a lot of attention owing to its attractive mechanism of action in pain processing pathway. We have previously reported our design of a novel series of tetrahydropyridine analogues towards hNav1.7 selective inhibitors. Herein, we disclose further efforts to the optimization of hit compound (-)-6, which led to the identification of aminocyclohexene analogues (-)-9 and (-)-17 with good potency, high selectivity, and minimal CYP inhibition. Both compounds (-)-9 and (-)-17 demonstrated improved pharmacokinetic profiles in rats, and robust efficacy in rat formalin-induced nociception and spinal nerve ligation (SNL) models...
November 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29032220/electodiagnostic-and-advanced-neuro-imaging-characterization-for-successful-treatment-of-a-spinal-extradural-arachnoid-cyst
#14
Tomoko Tanaka, Raja S Boddepalli, Douglas C Miller, Zongxian Cao, Vivek Sindhwani, Joan R Coates, Raghav Govindarajan, N Scott Litofsky
BACKGROUND: Spinal extradural arachnoid cysts (SEAC) are relatively uncommon. However, several large cysts have presented with spinal cord compression requiring surgical intervention. CASE DESCRIPTION: We report a patient with progressively enlarging SEAC causing worsening right S1 radiculopathy and gastrocnemius muscle atrophy. Electromyography (EMG) and nerve conduction studies (NCS) revealed an S1 motor radiculopathy. Serial magnetic resonance imaging (MRI) findings confirmed enlargement of the small cyst originating from the sacral thecal sac on the right while two smaller cyst on the left remained stable...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29017758/in-vitro-and-in-vivo-pharmacological-characterization-of-asp8477-a-novel-highly-selective-fatty-acid-amide-hydrolase-inhibitor
#15
Tomonari Watabiki, Noriko Tsuji, Tetsuo Kiso, Tohru Ozawa, Fumie Narazaki, Shuichiro Kakimoto
Although exogenous agonists for cannabinoid (CB) receptors are clinically effective for treating chronic pain, global activation of brain CB receptors causes frequent central nervous system (CNS) side-effects. Fatty acid amide hydrolase (FAAH) is a primary catabolic enzyme for anandamide (AEA), an endogenous CB. Recently, we discovered a novel FAAH inhibitor, 3-pyridyl 4-(phenylcarbamoyl)piperidine-1-carboxylate (ASP8477). In vitro studies demonstrated that ASP8477 inhibited human FAAH-1, FAAH-1 (P129T) and FAAH-2 activity with IC50 values of 3...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28961805/two-stage-en-bloc-resection-of-multilevel-cervical-chordomas-with-vertebral-artery-preservation-operative-technique
#16
Xingwen Wang, Eldan Eichbaum, Fengzeng Jian, Dean Chou
BACKGROUND: En bloc excision of cervical chordoma is a technically complex procedure, due to the involvement and closeness of the tumor to the spinal cord, cervical nerve roots, and vertebral arteries. Studies have previously shown that en bloc excision of chordomas with negative margins improves local control and prolongs disease-free survival compared with intralesional excision. True en bloc spondylectomy in the cervical spine is not feasible since bilateral vertebral artery sacrifice is not possible...
August 9, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28953050/repeated-administration-of-amitriptyline-in-neuropathic-pain-modulation-of-the-noradrenergic-descending-inhibitory-system
#17
Tadanao Hiroki, Takashi Suto, Shigeru Saito, Hideaki Obata
BACKGROUND: The tricyclic antidepressant amitriptyline, the serotonin and noradrenaline reuptake inhibitor duloxetine, and gabapentinoids are first-line drugs for treatment of neuropathic pain. The analgesic effect of these drugs relates to brainstem-spinal descending noradrenergic systems. However, amitriptyline utilizes a variety of mechanisms for analgesia in neuropathic pain, and it is unclear which mechanism is most important. In the present study, we investigated the role of descending noradrenergic systems in the analgesic effect of these drugs for treatment of neuropathic pain...
August 4, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28952182/effects-of-duloxetine-on-pain-and-walking-distance-in-neuropathic-pain-models-via-modulation-of-the-spinal-monoamine-system
#18
K Minami, R Tamano, E Kasai, H Oyama, M Hasegawa, S Shinohara, T Asaki
BACKGROUND: Approximately 40% of patients with chronic low back pain have a neuropathic component. In this study, we assessed the effects of analgesics on tactile hypersensitivity and walking distance in the rat cauda equina compression (CEC) model of neuropathic low back pain. METHODS: The effects of analgesics on tactile hypersensitivity were examined using the von Frey test in CEC and partial sciatic nerve ligation (pSNL) models. Effects on walking distance were assessed using a treadmill test...
September 26, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28935564/antinociception-induced-by-a-novel-%C3%AE-2a-adrenergic-receptor-agonist-in-rodents-acute-and-chronic-pain-models
#19
Roberto Takashi Sudo, Rachel Vieiralves do Amaral, Carlos Eduardo da Silva Monteiro, Ivan da Rocha Pitta, Maria do Carmo Lima, Guilherme Carneiro Montes, Douglas Gordon Ririe, Kenichiro Hayashida, Gisele Zapata-Sudo
The mechanisms and antinociceptive effects of a novel α2A adrenoceptor agonist, 3-(2-chloro-6-fluorobenzil)-imidazolinide-2,4-dione (PT-31) were investigated using animal models of acute and chronic pain. The effects of PT-31 on pain responses were examined using hot plate and formalin tests in mice and spinal nerve ligation (SNL)-induced hyperalgesia in rats. The effects of antagonists acting on α adrenoceptor were assessed to investigate the interaction of these pathways upon PT-31 induced antinociception...
November 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28919816/cxcr4-antagonist-amd3100-elicits-analgesic-effect-and-restores-the-glyr%C3%AE-3-expression-against-neuropathic-pain
#20
Xiaoming Liu, Hongjun Liu, Lihua Dai, Bingjie Ma, Ke Ma
OBJECTIVE: Chemokine CXCL12 and its receptor CXCR4 have been reported to play a critical role in neurogenesis and neuronal differentiation. Recently, some reports have implicated this chemokine signaling in the pathogenesis of many kinds of pain. However, its role in neuropathic pain (NP) is still largely unclear. This study explored the distribution and function of CXCR4 in spinal cord (SC) dorsal horn (DH) in a rat L5 spinal nerve ligation (SNL) model. METHODS: Rats received repeated intrathecal injection of CXCR4 antagonist AMD3100...
2017: Journal of Pain Research
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