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Spinal nerve injury

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https://www.readbyqxmd.com/read/28828216/sciatic-nerve-repair-using-poly-%C3%AE%C2%B5-caprolactone-tubular-prosthesis-associated-with-nanoparticles-of-carbon-and-graphene
#1
Kyl Assaf, Claudenete Vieira Leal, Mariana Silveira Derami, Eliana Aparecida de Rezende Duek, Helder Jose Ceragioli, Alexandre Leite Rodrigues de Oliveira
INTRODUCTION: Injuries to peripheral nerves generate disconnection between spinal neurons and the target organ. Due to retraction of the nerve stumps, end-to-end neurorrhaphy is usually unfeasible. In such cases, autologous grafts are widely used, nonetheless with some disadvantages, such as mismatching of donor nerve dimensions and formation of painful neuromas at the donor area. Tubulization, using bioresorbable polymers, can potentially replace nerve grafting, although improvements are still necessary...
August 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28827771/combinatory-repair-strategy-to-promote-axon-regeneration-and-functional-recovery-after-chronic-spinal-cord-injury
#2
Marc A DePaul, Ching-Yi Lin, Jerry Silver, Yu-Shang Lee
Eight weeks post contusive spinal cord injury, we built a peripheral nerve graft bridge (PNG) through the cystic cavity and treated the graft/host interface with acidic fibroblast growth factor (aFGF) and chondroitinase ABC (ChABC). This combinatorial strategy remarkably enhanced integration between host astrocytes and graft Schwann cells, allowing for robust growth, especially of catecholaminergic axons, through the graft and back into the distal spinal cord. In the absence of aFGF+ChABC fewer catecholaminergic axons entered the graft, no axons exited, and Schwann cells and astrocytes failed to integrate...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827698/nogo-receptor-1-regulates-caspr-distribution-at-axo-glial-units-in-the-central-nervous-system
#3
Jae Young Lee, Min Joung Kim, Lijun Li, Alexander A Velumian, Pei Mun Aui, Michael G Fehlings, Steven Petratos
Axo-glial units are highly organised microstructures propagating saltatory conduction and are disrupted during multiple sclerosis (MS). Nogo receptor 1 (NgR1) has been suggested to govern axonal damage during the progression of disease in the MS-like mouse model, experimental autoimmune encephalomyelitis (EAE). Here we have identified that adult ngr1 (-/-) mice, previously used in EAE and spinal cord injury experiments, display elongated paranodes, and nodes of Ranvier. Unstructured paranodal regions in ngr1 (-/-) mice are matched with more distributed expression pattern of Caspr...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827152/neuropathic-pain-attenuates-ischemia-reperfusion-injury-through-%C3%AE-2-adrenergic-pathway
#4
Shigeaki Kawai, Tokuhiro Yamada, Tadashi Matsuura, Tomoharu Funao, Kiyonobu Nishikawa
AIMS: The relationship between neuropathic pain and myocardial infarction (MI) was uncertain because of some medication or underlying diseases. This study investigated the impact of neuropathic pain on ischemia reperfusion injury using isolated rat hearts and cardiomyocytes. MAIN METHODS: Male Sprague-Dawley rats were assigned to the control and allodynia (AL) groups, with the latter subjected to the fifth lumbar spinal-nerve ligation. First, isolated hearts underwent 25-min ischemia and 90-min reperfusion to assess hemodynamic changes and MI area...
August 5, 2017: Life Sciences
https://www.readbyqxmd.com/read/28827126/illumina-deep-sequencing-reveals-conserved-and-novel-micrornas-involved-in-the-response-to-x-ray-irradiation-after-peripheral-nerve-injury-in-rats
#5
Bo Jiang, Yong Zhang, Jiaju Zhao, Chang She, Xiaozhong Zhou, Peiji Wang, Qirong Dong
Peripheral nerve injury is a common disease in clinic practice. Low-dose radiation exposure can increase recovery from peripheral nerve injury, but the mechanism is unclear. The objective of this study was to explore the ways that microRNAs participate in the recovery from peripheral nerve injury in rats. To explore the function of miRNAs in this process, we performed Illumina deep sequencing to investigate miRNA expression in spinal cords after X-ray irradiation. Two miRNA libraries (0 GY and 1 GY) were constructed for Illumina sequencing...
August 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28826918/surgical-management-of-142-cases-of-split-cord-malformations-associated-with-osseous-divide
#6
Tao Wang, Jian-Wen Gu, Tie-Jun Shi, Ke Li, Wei Wang, Xiao-Jun Bai, Jun-Hai Zhang, Zhi-Feng Yang, Shao-Jie Cui
OBJECTIVES: To investigate the key surgical points in treating split cord malformations associated with osseous divide and scoliosis (SCM-OD-S). MATERIALS AND METHODS: The surgical options and methods of a total of 142 SCM-OD-S cases were retrospectively analyzed, and the surgical precautions and imaging diagnosis were also discussed. RESULTS: The 142 patients were performed osseous divide resection plus dural sac molding, which achieved good results and no serious complication such as spinal cord and nerve injury occurred; certain symptoms such as urination-defecation disorders, muscle strength subsidence, Pes Cavus, and toe movement disorder in partial patients achieved various degrees of relief, and it also created good conditions for next-step treatment against scoliosis...
August 1, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28822786/leptin-is-essential-for-spinal-microglial-activation-and-neuropathic-pain-after-preganglionic-cervical-root-avulsion
#7
Kai-Ting Chang, Yi-Lo Lin, Chi-Te Lin, Chen-Jei Hong, May-Jywan Tsai, Wen-Cheng Huang, Yang-Hsin Shih, Yi-Yen Lee, Henrich Cheng, Ming-Chao Huang
AIMS: Preganglionic cervical root avulsion (PCRA) affects both the peripheral and central nervous systems and is often associated with neuropathic pain. Unlike peripheral nerve injuries (PNI), central lesions caused by disruption of cervical roots from the spinal cord following PCRA contribute to the generation of neuropathic pain. Leptin is involved in the development of neuropathic pain after PNI by affecting neurons. However, whether leptin is involved in microglial activation leading to neuropathic pain after PCRA is unknown...
August 16, 2017: Life Sciences
https://www.readbyqxmd.com/read/28821396/the-new-hdac1-inhibitor-lg325-ameliorates-neuropathic-pain-in-a-mouse-model
#8
Maria Domenica Sanna, Luca Guandalini, Maria Novella Romanelli, Nicoletta Galeotti
Current analgesic therapies for treatment of neuropathic pain are unsatisfactory. Neuropathic pain is, therefore, undertreated and there is a significant need for a better pharmacotherapy. Increasing evidence indicate that histone deacetylation is a critical step in nerve injury pain. To obtain an innovative treatment for the management of neuropathic pain, we investigated the pharmacological effects produced by the new histone deacetylase (HDAC)-1 selective inhibitor, LG325, in a mouse model of trauma-induced peripheral mononeuropathy provoked by spared nerve injury (SNI)...
August 15, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28814632/intermittent-apnea-elicits-inactivity-induced-phrenic-motor-facilitation-via-a-retinoic-acid-and-protein-synthesis-dependent-pathway
#9
Nathan A Baertsch, Tracy L Baker
Respiratory motoneuron pools must provide rhythmic inspiratory drive that is robust and reliable, yet dynamic enough to respond to respiratory challenges. One form of plasticity that is hypothesized to contribute to motor output stability by sensing and responding to inadequate respiratory neural activity is inactivity-induced phrenic motor facilitation (iPMF), an increase in inspiratory output triggered by a reduction in phrenic synaptic inputs. Evidence suggests that mechanisms giving rise to iPMF differ depending on the pattern of reduced respiratory neural activity (i...
August 16, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28809870/-case-report-iatrogenic-shoulder-pain-syndrome-following-spinal-accessory-nerve-injury-during-lateral-cervical-neck-dissection-for-tongue-cancer-the-role-of-rehabilitation-and-ethical-deontological-issues
#10
Gianpaolo Ronconi, Antonio Gioacchino Spagnolo, Giorgio Ferriero, Silvia Giovannini, Eugenia Amabile, Giulio Maccauro, Paola Emilia Ferrara
The shoulder pain syndrome is the most frequent complication of lateral cervical neck dissection and may be caused by iatrogenic injury to the spinal accessory nerve, causing pain and functional limitation of the upper limb and of the cervical spine. Interdisciplinary collaboration and early rehabilitation can reduce the consequences of disability and the possible issues that can arise due to inadequate management of the problem.
May 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/28808582/ludwig-guttmann-s-memorandum-a-review-on-the-surgical-aspects-of-spinal-cord-injuries-written-in-1944-for-the-nerve-injury-committee-of-the-medical-research-council-with-notes-and-commentary
#11
https://www.readbyqxmd.com/read/28807492/neuropsychiatric-involvement-in-lupus-is-associated-with-the-nogo-a-ngr1-pathway
#12
Hong-Wei Lei, Jing-Yuan Wang, Qiu-Jie Dang, Fan Yang, Xin Liu, Ji-Hui Zhang, Yang Li
Neuroinflammation- and neurodegeneration-induced nerve injury may represent important components of neuropsychiatric lupus (NPSLE). Myelin-associated neurite outgrowth inhibitor (Nogo)-a and its receptor, NgR1, limit recovery of the adult central nervous system after injury. We detected a soluble Nogo-a product in the cerebral spinal fluid of patients with NPSLE. In a mouse model of lupus, aging was associated with an increase in Nogo-a positive neurons, diminished myelin sheaths, enhanced pro-inflammatory cytokines, and impaired cognition and memory...
July 9, 2017: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28806211/the-opiorphin-analog-str-324-decreases-sensory-hypersensitivity-in-a-rat-model-of-neuropathic-pain
#13
Alain Van Elstraete, Philippe Sitbon, Leila Hamdi, Victor Juarez-Perez, Jean-Xavier Mazoit, Dan Benhamou, Catherine Rougeot
BACKGROUND: Neuropathic pain represents a therapeutic challenge, and treatments with increased efficacy and tolerability still need to be developed. Opiorphin protects endogenous enkephalins from degradation, potentiating enkephalin-dependent analgesia via the activation of opioid pathways. Enkephalins are natural ligands of opioid receptors, with strong affinity for δ-opioid receptors. Expression of functional δ-opioid receptors increases in sensory neurons after peripheral nerve injury in neuropathic pain models...
August 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28804608/remyelination-improvement-after-neurotrophic-factors-secreting-cells-transplantation-in-rat-spinal-cord-injury
#14
Shahnaz Razavi, Nazem Ghasemi, Mohammad Mardani, Hossein Salehi
OBJECTIVES: Neurotrophic factors secreting cells (NTS-SCs) may be a superior cell source for cell-based therapy in neurodegenerative diseases. NTS-SCs are able to secrete some neurotrophic Such as nerve growth factor and glia-derived neurotrophic factor. Our primary aim was to assess transplantation of neurotrophic factor secreting cells derived from human adipose-derived stem cells (hADSCs) into the damaged spinal cord rats and determine the potential of these cells in remyelination...
April 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28801220/multiple-reflex-pathways-contribute-to-bladder-activation-by-intraurethral-stimulation-in-persons-with-spinal-cord-injury
#15
Meredith J McGee, Brandon D Swan, Zachary C Danziger, Cindy L Amundsen, Warren M Grill
OBJECTIVES: To measure the urodynamic effects of electrical co-stimulation of two individual sites in the proximal and distal urethra in persons with spinal cord injury (SCI). This work was motivated by preclinical findings that selective co-stimulation of the cranial urethral sensory nerve and the dorsal genital nerve, which innervate the proximal and distal portions of the urethra, respectively, increased reflex bladder activation and voiding efficiency. METHODS: Electrical co-stimulation of urethral afferents was conducted in persons with chronic SCI during urodynamics...
August 8, 2017: Urology
https://www.readbyqxmd.com/read/28801063/chondroitin-sulfates-do-not-impede-axonal-regeneration-in-goldfish-spinal-cord
#16
Akihito Takeda, Soichiro Okada, Kengo Funakoshi
Chondroitin sulfate proteoglycans produced in glial scar tissue are a major inhibitory factor for axonal regeneration after central nervous system injury in mammals. The inhibition is largely due to chondroitin sulfates, whose effects differ according to the sulfation pattern. In contrast to mammals, fish nerves spontaneously regenerate beyond the scar tissue after spinal cord injury, although the mechanisms that allow for axons to pass through the scar are unclear. Here, we used immunohistochemistry to examine the expression of two chondroitin sulfates with different sulfation variants at the lesion site in goldfish spinal cord...
August 8, 2017: Brain Research
https://www.readbyqxmd.com/read/28794655/p2y12-and-p2y13-receptors-involved-in-adp%C3%AE-s-induced-the-release-of-il-1%C3%AE-il-6-and-tnf-%C3%AE-from-cultured-dorsal-horn-microglia
#17
Pei-Wen Liu, Ming-Xia Yue, Rui Zhou, Juan Niu, Du-Juan Huang, Tao Xu, Pei Luo, Xiao-Hong Liu, Jun-Wei Zeng
OBJECTIVE: P2 receptors have been implicated in the release of neurotransmitter and pro-inflammatory cytokines due to their response to neuroexcitatory substances in the microglia. Dorsal horn P2Y12 and P2Y13 receptors are involved in the development of pain behavior induced by peripheral nerve injury. However, it is not known whether P2Y12 and P2Y13 receptors activation is associated with the expression and the release of interleukin-1B (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in cultured dorsal spinal cord microglia...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28790970/structural-and-functional-substitution-of-deleted-primary-sensory-neurons-by-new-growth-from-intrinsic-spinal-cord-nerve-cells-an-alternative-concept-in-reconstruction-of-spinal-cord-circuits
#18
Nicholas D James, Maria Angéria, Elizabeth J Bradbury, Peter Damberg, Stephen B McMahon, Mårten Risling, Thomas Carlstedt
In a recent clinical report, return of the tendon stretch reflex was demonstrated after spinal cord surgery in a case of total traumatic brachial plexus avulsion injury. Peripheral nerve grafts had been implanted into the spinal cord to reconnect to the peripheral nerves for motor and sensory function. The dorsal root ganglia (DRG) containing the primary sensory nerve cells had been surgically removed in order for secondary or spinal cord sensory neurons to extend into the periphery and replace the deleted DRG neurons...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28779869/functional-integration-of-complex-mirna-networks-in-central-and-peripheral-lesion-and-axonal-regeneration
#19
REVIEW
M Ghibaudi, M Boido, A Vercelli
New players are emerging in the game of peripheral and central nervous system injury since their physiopathological mechanisms remain partially elusive. These mechanisms are characterized by several molecules whose activation and/or modification following a trauma is often controlled at transcriptional level. In this scenario, microRNAs (miRNAs/miRs) have been identified as main actors in coordinating important molecular pathways in nerve or spinal cord injury (SCI). miRNAs are small non-coding RNAs whose functionality at network level is now emerging as a new level of complexity...
August 2, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28777065/possible-role-of-antioxidative-capacity-of-epigallocatechin-3-gallate-treatment-in-morphological-and-neurobehavioral-recovery-after-sciatic-nerve-crush-injury
#20
Waleed M Renno, Ludmil Benov, Khalid M Khan
OBJECTIVE This study examined the capacity of the major polyphenolic green tea extract (-)-epigallocatechin-3-gallate (EGCG) to suppress oxidative stress and stimulate the recovery and prompt the regeneration of sciatic nerve after crush injury. METHODS Adult male Wistar rats were randomly assigned to one of 4 groups: 1) Naïve, 2) Sham (sham injury, surgical control group), 3) Crush (sciatic nerve crush injury treated with saline), and 4) Crush+EGCG (sciatic nerve crush injury treated with intraperitoneally administered EGCG, 50 mg/kg)...
August 4, 2017: Journal of Neurosurgery. Spine
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