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azythromycin inflammation

Mario H Vargas, Rosangela Del-Razo-Rodríguez, Amando López-García, José Luis Lezana-Fernández, Jaime Chávez, María E Y Furuya, Juan Carlos Marín-Santana
BACKGROUND: Patients with cystic fibrosis (CF) have airway inflammation that contributes to symptoms and to pulmonary function derangement. Current drugs used to diminish airway inflammation improve the clinical and spirometric status of patients with CF, but their use is limited due to their undesired side effects, for example, glucose intolerance, growth retardation, and cataracts with corticosteroids, gastrointestinal toxicity with ibuprofen, and macrolide resistance with azythromycin...
December 15, 2017: BMC Pulmonary Medicine
Marco Zeppieri, Maria Letizia Salvetat, Antonio Beltrami, Daniela Cesselli, Rossella Russo, Ignacio Alcalde, Jesús Merayo-Lloves, Paolo Brusini, Pier Camillo Parodi
The aim of our study was to assess the clinical effectiveness of topical adipose derived stem cell (ADSC) treatment in laser induced corneal wounds in mice by comparing epithelial repair, inflammation, and histological analysis between treatment arms. Corneal lesions were performed on both eyes of 40 mice by laser induced photorefractive keratectomy. All eyes were treated with topical azythromycin bid for three days. Mice were divided in three treatment groups ( n = 20), which included: control, stem cells and basic serum; which received topical treatment three times daily for five consecutive days...
December 5, 2017: Journal of Clinical Medicine
Blaise Noa Noatina, Giles Kagmeni, Yaya Souleymanou, Henri Claude Moungui, Ann Tarini Hien, Julie Akame, Yaobi Zhang, Assumpta Lucienne Françoise Bella
BACKGROUND: To estimate the prevalence of trachoma in the North Region of Cameroon in order to facilitate the planning of trachoma control activities in this region, a survey was carried out in 2011 and 2012 in 15 health districts (HDs). METHODOLOGY: A cross-sectional, two-stage cluster random sampling survey was carried out. The survey focused on two target populations: children aged 1 to 9 years for the prevalence of Trachomatous Inflammation-Follicular (TF) and those aged 15 and over for the prevalence of Trachomatous Trichiasis (TT)...
June 2014: PLoS Neglected Tropical Diseases
Akira Tokuda, Noriyuki Ohkura, Masaki Fujimura, Shiho Furusho, Miki Abo, Nobuyuki Katayama
BACKGROUND: Macrolides are antibiotics that have anti-inflammatory activities. Hence, they are used for both acute and chronic inflammatory airway diseases. However, the effects of these agents on allergic airway disorders presenting with an isolated chronic cough, such as non-asthmatic eosinophilic bronchitis and eosinophilic tracheobronchitis with cough hypersensitivity (atopic cough), still remain to be elucidated. OBJECTIVE: To determine if macrolides are effective in the management of chronic cough caused by eosinophilic airway inflammation...
February 2010: Pulmonary Pharmacology & Therapeutics
D F Florescu, P J Murphy, A C Kalil
Azithromycin has been studied as potential therapeutic anti-inflammatory agent for cystic fibrosis (CF) patients. Azithromycin (AZM) has been used as an immunomodulating agent, based on few small studies. Considering the cost and potential side effects of long-term azithromycin therapy, it is important to identify the group of patients that would benefit the most. Weighted mean difference was used for pulmonary function tests, and risk ratios for all other variables. The random-effects model was applied for all reports...
December 2009: Pulmonary Pharmacology & Therapeutics
E Novembre, F Mori, N Pucci, R Bernardini, A Vierucci, M de Martino
Systemic acute rhinosinusitis therapy consists mostly of antibiotic treatment because pathogens play a major role. Amoxicillin is the drug of choice for treatment of acute rhinosinusitis, with second- and third- generation cephalosporins, azythromycin, clarithromycin, and telithromycin as possible options, especially in the case of allergy to amoxicillin. If the clinical course suggests that an anaerobic pathogen is more likely, clindamycin or metronidazole can be considered in combination with a broad-spectrum drug...
November 2007: Pediatric Allergy and Immunology
Kristi Watterberg
Inflammation has been linked to numerous adverse outcomes in newborns. This paper reviews several major sources of inflammation, methods to reduce exposure, current anti-inflammatory drug therapy and future research directions. The first major source of inflammation--chorioamnionitis--is often present long before delivery; postnatal interventions may not alter outcomes. Reducing the exposure of preterm infants to postnatal inflammatory stimuli such as mechanical ventilation and sepsis may be more effective than anti-inflammatory drug therapy in improving outcomes...
October 2006: Seminars in Fetal & Neonatal Medicine
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