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https://www.readbyqxmd.com/read/28102535/circus-disaster-case-report-response-and-review-of-injuries
#1
Nicholas Asselin, Lawrence Proano, Kenneth Williams, Robert Partridge
Circus acts with human artists performing acrobatic feats are a popular spectator pastime in the United States and in international venues. There is little data in the literature regarding injuries sustained during circus acts. Some injuries are minor, but others can be serious, or even fatal. This article describes a recent circus disaster, a review of the relevant literature, and an analysis of the disaster response.
April 2016: American Journal of Disaster Medicine
https://www.readbyqxmd.com/read/28060788/outpatient-total-hip-arthroplasty-total-knee-arthroplasty-and-unicompartmental-knee-arthroplasty-a-systematic-review-of-the-literature
#2
Michael Pollock, Lyndsay Somerville, Andrew Firth, Brent Lanting
BACKGROUND: The demand for total hip arthroplasty (THA), total knee arthroplasty (TKA), and unicompartmental knee arthroplasty (UKA) is growing rapidly because of the proven success of these procedures and an increase in the aging population. However, resources are limited and health-care budgets are finite. Recently, a number of care providers have started performing these procedures on an outpatient basis, with the patients being discharged from the hospital on the day of surgery. The primary objective of this systematic review was to examine the evidence regarding the safety and feasibility of performing THA, TKA, or UKA on an outpatient basis...
December 27, 2016: JBJS Reviews
https://www.readbyqxmd.com/read/28058751/allergen-immunotherapy-for-ige-mediated-food-allergy-a-systematic-review-and-meta-analysis
#3
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars K Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. METHODS: We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and non-randomized studies (NRS)...
January 6, 2017: Allergy
https://www.readbyqxmd.com/read/27941637/investigating-sterol-and-redox-regulation-of-the-ion-channel-activity-of-clic1-using-tethered-bilayer-membranes
#4
Heba Al Khamici, Khondher R Hossain, Bruce A Cornell, Stella M Valenzuela
The Chloride Intracellular Ion Channel (CLIC) family consists of six conserved proteins in humans. These are a group of enigmatic proteins, which adopt both a soluble and membrane bound form. CLIC1 was found to be a metamorphic protein, where under specific environmental triggers it adopts more than one stable reversible soluble structural conformation. CLIC1 was found to spontaneously insert into cell membranes and form chloride ion channels. However, factors that control the structural transition of CLIC1 from being an aqueous soluble protein into a membrane bound protein have yet to be adequately described...
December 8, 2016: Membranes
https://www.readbyqxmd.com/read/27900175/free-fall-acrobatics-to-reduce-neck-loads-during-parachute-opening-shock-evaluation-of-an-intervention-acropose
#5
Anton Westman, Björn O Äng
INTRODUCTION: Neck pain is a widespread health problem in the skydiver athlete population, epidemiologically linked to repeated exposure to parachute opening shock (POS). During POS, a parachutist is subjected to considerable deceleration forces. This study aims to evaluate the use of preventive free fall acrobatics to reduce the biomechanical load on the neck of parachutists during parachute opening. METHODS AND ANALYSIS: Interventional study with a cross-over, within-subject, repeated measures design...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27893079/endoscopic-repair-of-tympanic-membrane-perforations-an-exercise-of-acrobatic-dexterity-or-the-sign-of-the-beginning-of-a-new-era-in-otology
#6
Manuela Fina
No abstract text is available yet for this article.
January 1, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27867136/pediatric-orthopedic-surgery-in-humanitarian-aid
#7
REVIEW
J Sales de Gauzy, J-F Trinchero, J-L Jouve
Pediatric orthopedic surgery in humanitarian aid is conducted mainly in cooperation with emerging countries. Each mission is different, and depends on numerous parameters such as the country, the frequency of such missions, the pathologies encountered, the local structure and team, and the non-governmental organization (NGO) involved. Pathologies vary in etiology (tuberculosis, poliomyelitis) and severity. Each mission requires the presence of an experienced surgeon. Working conditions are often rudimentary...
November 17, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27810896/an-acrobatic-substrate-metamorphosis-reveals-a-requirement-for-substrate-conformational-dynamics-in-trypsin-proteolysis
#8
Olumide Kayode, Ruiying Wang, Devon F Pendlebury, Itay Cohen, Rachel D Henin, Alexandra Hockla, Alexei S Soares, Niv Papo, Thomas R Caulfield, Evette S Radisky
The molecular basis of enzyme catalytic power and specificity derives from dynamic interactions between enzyme and substrate during catalysis. Although considerable effort has been devoted to understanding how conformational dynamics within enzymes affect catalysis, the role of conformational dynamics within protein substrates has not been addressed. Here, we examine the importance of substrate dynamics in the cleavage of Kunitz-bovine pancreatic trypsin inhibitor protease inhibitors by mesotrypsin, finding that the varied conformational dynamics of structurally similar substrates can profoundly impact the rate of catalysis...
December 16, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27753974/os-12-01-arb-and-ccb-longest-combination-treatment-on-ambulatory-and-home-bp-in-hypertension-with-atrial-fibrillation-multicenter-study-on-time-of-dosing-acrobat
#9
Kazuomi Kario, Satoshi Hoshide
OBJECTIVE: It has been long believed that there is a close association between hypertension and atrial fibrillation (AF). However, there have been few studies on the impact of antihypertensive medication in hypertensives with AF. To investigate whether the timing of the antihypertensive drug administration influences blood pressure (BP) level and biomarkers to hypertensives with AF. DESIGN AND METHOD: The present study was a multicentered, prospective, randomized, open-labelled clinical trial to investigate the difference in the effect of telmisartan/amlodipine combination tablets on BP levels and BP variability using ambulatory BP monitoring (ABPM) and home BP between the morning administration and the bedtime administration in hypertensives with paroxysmal AF...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27717360/the-effect-of-changing-the-built-environment-on-physical-activity-a-quantitative-review-of-the-risk-of-bias-in-natural-experiments
#10
Jack S Benton, Jamie Anderson, Ruth F Hunter, David P French
BACKGROUND: Evidence regarding the association of the built environment with physical activity is influencing policy recommendations that advocate changing the built environment to increase population-level physical activity. However, to date there has been no rigorous appraisal of the quality of the evidence on the effects of changing the built environment. The aim of this review was to conduct a thorough quantitative appraisal of the risk of bias present in those natural experiments with the strongest experimental designs for assessing the causal effects of the built environment on physical activity...
October 7, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27643371/os-12-01-arb-and-ccb-longest-combination-treatment-on-ambulatory-and-home-bp-in-hypertension-with-atrial-fibrillation-multicenter-study-on-time-of-dosing-acrobat
#11
Kazuomi Kario, Satoshi Hoshide
OBJECTIVE: It has been long believed that there is a close association between hypertension and atrial fibrillation (AF). However, there have been few studies on the impact of antihypertensive medication in hypertensives with AF. To investigate whether the timing of the antihypertensive drug administration influences blood pressure (BP) level and biomarkers to hypertensives with AF. DESIGN AND METHOD: The present study was a multicentered, prospective, randomized, open-labelled clinical trial to investigate the difference in the effect of telmisartan/amlodipine combination tablets on BP levels and BP variability using ambulatory BP monitoring (ABPM) and home BP between the morning administration and the bedtime administration in hypertensives with paroxysmal AF...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27542804/emergency-department-care-of-childhood-epistaxis
#12
REVIEW
E Béquignon, N Teissier, A Gauthier, L Brugel, H De Kermadec, A Coste, V Prulière-Escabasse
OBJECTIVE: The aim of this review is to determine an efficient and safe primary strategy care for paediatric epistaxis. DATA SOURCES: We searched PubMed and Cochrane databases for studies referenced with key words 'epistaxis AND childhood'. This search yielded 32 research articles about primary care in childhood epistaxis (from 1989 to 2015). Bibliographic references found in these articles were also examined to identify pertinent literature. We compared our results to the specific management of adult epistaxis classically described in the literature...
August 19, 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/27527912/the-pathophysiology-associated-with-primary-idiopathic-frozen-shoulder-a-systematic-review
#13
Victoria Ryan, Hazel Brown, Catherine J Minns Lowe, Jeremy S Lewis
BACKGROUND: Frozen shoulder is a common yet poorly understood musculoskeletal condition, which for many, is associated with substantial and protracted morbidity. Understanding the pathology associated with this condition may help to improve management. To date this has not been presented in a systematic fashion. As such, the aim of this review was to summarise the pathological changes associated with this primary frozen shoulder. METHODS: HASH(0x35e5d18) DATABASES: Medline, Embase, CINAHL, AMED, BNI and the Cochrane Library, were searched from inception to 2nd May, 2014...
2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27348399/care-models-in-the-management-of-haemophilia-a-systematic-review
#14
REVIEW
C H T Yeung, N Santesso, M Pai, C Kessler, N S Key, M Makris, T Navarro-Ruan, J M Soucie, H J Schünemann, A Iorio
BACKGROUND: Haemophilia care is commonly provided via multidisciplinary specialized management. To date, there has been no systematic assessment of the impact of haemophilia care delivery models on patient-important outcomes. OBJECTIVE: To conduct a systematic review of published studies assessing the effects of the integrated care model for persons with haemophilia (PWH). SEARCH METHODS: We searched MEDLINE, EMBASE and CINAHL up to April 22, 2015, contacted experts in the field, and reviewed reference lists...
July 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27265094/motor-skills-training-improves-sensorimotor-dysfunction-and-increases-microtubule-associated-protein-2-mrna-expression-in-rats-with-intracerebral-hemorrhage
#15
Keigo Tamakoshi, Kentaro Kawanaka, Hideaki Onishi, Yasuyuki Takamatsu, Kazuto Ishida
BACKGROUND: In this study, we examined the effects of motor skills training on the sensorimotor function and the expression of genes associated with synaptic plasticity after intracerebral hemorrhage (ICH) in rats. METHODS: Male Wistar rats were subjected to ICH or sham operation. ICH was caused by the injection of collagenase into the left striatum. Rats were randomly assigned to no training, acrobatic training, and sham groups. The acrobatic group performed 5 types of acrobatic tasks from 4 to 28 days after surgery...
August 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27126278/distinct-neuroplasticity-processes-are-induced-by-different-periods-of-acrobatic-exercise-training
#16
Samira Salame, Priscila C Garcia, Caroline C Real, Juliana Borborema, Sandra R Mota-Ortiz, Luiz R G Britto, Raquel S Pires
Short and long-term physical exercise induce physiological and structural changes in brain motor areas. The relationship between changes of structural and synaptic proteins in brain motor areas and acrobatic exercise is less understood. Our aim was to evaluate the expression of synapsin I (SYS), synaptophysin (SYP), microtubule-associated protein 2 (MAP2), neurofilament (NF), and a marker for recent neuronal activity (Egr-1) in the motor cortex, striatum and cerebellum of adult rats subjected to acrobatic exercise (AE, for 1-4 weeks)...
July 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27125333/clinical-outcomes-of-hiv-exposed-hiv-uninfected-children-in-sub-saharan-africa
#17
REVIEW
Stanzi M le Roux, Elaine J Abrams, Kelly Nguyen, Landon Myer
OBJECTIVE: HIV-exposed but HIV-uninfected (HEU) children are widely considered at increased risk of mortality and morbidity. Recent advances in prevention of mother-to-child HIV transmission (PMTCT) strategies, incorporating life-long universal maternal antiretroviral therapy (ART, "Option B+") with extended breastfeeding, may improve HEU child health substantially. We critically reviewed reports of mortality/morbidity among HEU and HIV-unexposed (HU) children in sub-Saharan Africa. METHODS: We searched Medline, EMBASE, CINAHL, PsycINFO, Academic Search Premier, Global Health & Psychosocial Instruments databases, conference abstracts, and reference lists for longitudinal studies from sub-Saharan Africa reporting mortality and clinical morbidity among HIV-uninfected children aged ≤10 years, by maternal HIV status...
July 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27088216/a-validated-method-for-modeling-anthropoid-hip-abduction-in-silico
#18
Ashley S Hammond, J Michael Plavcan, Carol V Ward
OBJECTIVES: The ability to reconstruct hip joint mobility from femora and pelves could provide insight into the locomotion and paleobiology of fossil primates. This study presents a method for modeling hip abduction in anthropoids validated with in vivo data. METHODS: Hip abduction simulations were performed on a large sample of anthropoids. The modeling approach integrates three-dimensional (3D) polygonal models created from laser surface scans of bones, 3D landmark data, and shape analysis software to digitally articulate and manipulate the hip joint...
July 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27067379/select-forelimb-muscles-have-evolved-superfast-contractile-speed-to-support-acrobatic-social-displays
#19
Matthew J Fuxjager, Franz Goller, Annika Dirkse, Gloria D Sanin, Sarah Garcia
Many species perform rapid limb movements as part of their elaborate courtship displays. However, because muscle performance is constrained by trade-offs between contraction speed and force, it is unclear how animals evolve the ability to produce both unusually fast appendage movement and limb force needed for locomotion. To address this issue, we compare the twitch speeds of forelimb muscles in a group of volant passerine birds, which produce different courtship displays. Our results show that the two taxa that perform exceptionally fast wing displays have evolved 'superfast' contractile kinetics in their main humeral retractor muscle...
April 12, 2016: ELife
https://www.readbyqxmd.com/read/27027525/adaptive-evolution-of-a-derived-radius-morphology-in-manakins-aves-pipridae-to-support-acrobatic-display-behavior
#20
Anthony Friscia, Gloria D Sanin, Willow R Lindsay, Lainy B Day, Barney A Schlinger, Josh Tan, Matthew J Fuxjager
The morphology of the avian skeleton is often studied in the context of adaptations for powered flight. The effects of other evolutionary forces, such as sexual selection, on avian skeletal design are unclear, even though birds produce diverse behaviors that undoubtedly require a variety of osteological modifications. Here, we investigate this issue in a family of passerine birds called manakins (Pipridae), which have evolved physically unusual and elaborate courtship displays. We report that, in species within the genus Manacus, the shaft of the radius is heavily flattened and shows substantial solidification...
June 2016: Journal of Morphology
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