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incompatibility rh

Tarun Handa, Shalu Jhajra, Shweta Bhagat, P V Bharatam, Asit K Chakraborti, Saranjit Singh
Combination therapy with the use of fixed-dose combinations (FDCs) is evincing increasing interest of prescribers, manufacturers and even regulators, evidently due to the primary benefit of improved patient compliance. However, owing to potential of drug-drug interaction, FDCs require closer scrutiny with respect to their physical and chemical stability. Accordingly, the purpose of the present study was to explore stability behavior of a popular antihypertensive combination of amlodipine besylate (AML) and losartan potassium (LST)...
March 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
Manish Jain, Akash Bang, Anju Tiwari, Shuchi Jain
BACKGROUND: Neonatal jaundice is a common problem. We evaluated the utility and best cut-off values of 24-and 48-hour transcutaneous bilirubin indices (TcBI) in predicting subsequent significant hyperbilirubinemia and evaluated various associated maternal and fetal risk factors. METHODS: TcBI at 24 and 48 hours and serum bilirubin levels at 72 hours of age were obtained for healthy, term, appropriate for gestational age neonates. Neonates with prematurity, birth weight <2500 g, ABO or Rh incompatibility, onset of clinical jaundice <24 hours, clinical suspicion of septicemia, positive pressure ventilation at birth, admission in neonatal intensive care unit and contraindications for BiliChek were excluded...
November 23, 2016: World Journal of Pediatrics: WJP
S Sukhbir, S Yashpal, A Sandeep
Nefopam hydrochloride (NFH) is a non-opioid centrally acting analgesic drug used to treat chronic condition such as neuropathic pain. In current research, sustained release nefopam hydrochloride loaded nanospheres (NFH-NS) were auspiciously synthesized using binary mixture of eudragit RL 100 and RS 100 with sorbitan monooleate as surfactant by quasi solvent diffusion technique and optimized by 3(5) Box-Behnken designs to evaluate the effects of process and formulation variables. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetric (DSC) and X-ray diffraction (XRD) affirmed absence of drug-polymer incompatibility and confirmed formation of nanospheres...
September 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
Daynia E Ballot, Gilbert Rugamba
Background. Severe hyperbilirubinaemia requiring exchange transfusion has become less common in recent years; however, kernicterus still occurs. The aim of this study was to review babies undergoing exchange transfusion for severe hyperbilirubinaemia in a Johannesburg hospital. Methodology. This was a retrospective review of babies who required exchange transfusion in both the neonatal and the paediatric wards from June 1, 2006, to December 31, 2011. Results. There were 64 patients who underwent 67 exchange transfusions...
2016: International Scholarly Research Notices
Huseyin Bilgin, Abdulkadir Eren, Semra Kara
Many different blood group systems, such as Rh, ABO, Kell, Kidd, Duffy, MNS, have been reported as causes of hemolytic disease of the newborn. Hemolysis due to minor blood group incompatibility in the fetus or newborn has been determined in isolated case reports. Here, we report a case of a patient who had received red cell transfusion due to severe Rh c and E incompatibility, leading to hemolytic anemia with heart failure. The mother and the baby were grouped B and B, respectively, both being positive for RhD antigen...
June 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Anet Papazovska Cherepnalkovski, Vjekoslav Krzelj, Beti Zafirovska-Ivanovska, Todor Gruev, Josko Markic, Natasa Aluloska, Nikolina Zdraveska, Katica Piperkovska
BACKGROUND: Neonatal jaundice that occurs in ABO or Rhesus issoimunisation has been recognized as one of the major risk factors for development of severe hyperbilirubinemia and bilirubin neurotoxicity. AIM: Aim of our study was to investigate clinical and laboratory parameters associated with hemolytic jaundice due to Rh and ABO incompatibility and compare results with the group of unspecific jaundice. MATERIAL AND METHODS: One hundred sixty seven (167) neonatal hyperbilirubinemia cases were included in the study, 24...
December 15, 2015: Open Access Macedonian Journal of Medical Sciences
Önder Arslan, Hasan Şanol Coşkun, Mutlu Arat, Ender Soydan, Muhit Özcan, Günhan Gürman, Harika Çelebi, Taner Demirer, Hamdi Akan, Osnman İlhan, Nahide Konuk, Akın Uysal, Meral Berksaç, Haluk Koç
ABO incompatibility is not a contraindication for allogeneic bone marrow transplantation, but this procedure requires an extra effort for erythrocyte or plasma depletion in certain well established conditions. Some acute or delayed immunohematological complications such as acute or chronic hemolysis and pure red cell aplasia may be encountered. In this study the outcome and transplant related complications of ABO incompatible and identical cases, who have received allogeneic peripheral blood stem cells from their HLA identical siblings were compared with each other...
September 5, 2002: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
Mehraboon S Irani, Matthew S Karafin, Luke Ernster
PURPOSE: A red cell exchange was performed to prevent a potentially fatal hemolytic transfusion reaction in a patient with anti-e who was transfused with e-antigen unscreened red blood cells during liver transplant surgery. CASE REPORT: A 64-year-old woman with cirrhosis due to hepatitis C was scheduled to receive a liver transplant. She had a previously documented anti-e, an antibody to the Rh(e)-antigen that is known to cause delayed hemolytic transfusion reactions...
February 2017: Journal of Clinical Apheresis
Nevenka Bujandric, Jasmina Grujic
This study aimed to evaluate the frequency of the main risk factors for severe neonatal hyperbilirubinemia, to determine the incidence of exchange transfusion (ET) in the Autonomous Province of Vojvodina (the northern part of Serbia) and to describe the experience with ET performed in premature and term infants during the past 17 years. We performed a retrospective data analysis of 398 newborn infants who underwent a double volume ET from 1997 to 2013. During the 17 year study period, a decreasing incidence of ET, expressed per thousand newborns, was observed...
June 2016: Indian Journal of Hematology & Blood Transfusion
G Arnolda, H M Nwe, D Trevisanuto, A A Thin, A A Thein, T Defechereux, D Kumara, L Moccia
BACKGROUND: Jaundice is the commonest neonatal ailment requiring treatment. Untreated, it can lead to acute bilirubin encephalopathy (ABE), chronic bilirubin encephalopathy (CBE) or death. ABE and CBE have been largely eliminated in industrialised countries, but remain a problem of largely undocumented scale in low resource settings. As part of a quality-improvement intervention in the Neonatal Care Units of two paediatric referral hospitals in Myanmar, hospitals collected de-identified data on each neonate treated on new phototherapy machines over 13-20 months...
2015: Maternal Health, Neonatology and Perinatology
M Mehrmohammadi
BACKGROUND: Parental blood variables are one of the most important medical-biological causes of intellectual and physical-movement disabilities. The purpose of this study was to identify the relationship between parents' blood variables (ABO and Rh blood type) and their relationship with frequency of intellectual and physical-movement disabilities in Isfahan province. MATERIALS AND METHODS: This was a descriptive-analytical study and 494 samples were selected from mothers with more than one disabled child and mothers with normal child using simple and multistage random methods...
2015: Iranian Journal of Pediatric Hematology and Oncology
Wafaa Moustafa M Abo El Fotoh, Mohammed Soliman Rizk
BACKGROUND: The enzyme, Glucose-6-phosphate dehydrogenase (G6PD), deficiency leads to impaired production of reduced glutathione and predisposes the red cells to be damaged by oxidative metabolites, causing hemolysis. Deficient neonates may manifest clinically as hyperbilirubinemia or even kernicterus. OBJECTIVE: This study was carried out to detect erythrocyte G6PD deficiency in neonatal hyperbilirubinemia. METHODS AND DESIGN: To determine the frequency and effect of G6PD deficiency, this study was conducted on 202 neonates with indirect hyperbilirubinemia...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
Taísa Roberta Ramos Nantes de Castilho, Marcelli Salete Vargas, Adriana Pinsuti, Marcos Augusto Rocha, Jose Ricardo D'Bertagnon
The authors present the case of a newborn of an Rh-factorsensitized mother, who received early hospital discharge while icteric only to be readmitted at an Emergency Service at five days of age with signs of kernicterus. Despite treatment given, the neonate progressed with a clinical picture of bilirubin encephalopathy. The lack of interaction between the obstetric and neonatal teams, premature hospital discharge, and lack of concern of neonatologists with jaundice in a full-term infant are highlighted as causes of a condition that should have disappeared if there had been adequate prevention...
June 2011: Einstein
A R Hurtarte-Sandoval, M D Navarro-Cabello, M A Álvarez-Rivas, A I Robles-López, M D Salmerón-Rodríguez, M L Agüera-Morales, A Rodríguez-Benot, P Aljama-García
BACKGROUND: Passenger lymphocyte syndrome (PLS) is a disease in which the donor's lymphocytes produce antibodies to the red blood cell antigens of the recipient, causing alloimmune hemolysis. CASE REPORT: We report the case of a 39-year-old woman with stage V chronic kidney disease on hemodialysis secondary to poorly controlled diabetes mellitus type 1. She received a simultaneous pancreas-kidney transplant from a cadaver donor. The donor was A- and the recipient was A+ without initial complications with normal renal and pancreatic function, and her hemoglobin (Hb) level was 10...
November 2015: Transplantation Proceedings
T Malla, S Singh, P Poudyal, B Sathian, G Bk, K K Malla
BACKGROUND: An exchange transfusion involves replacing patient's blood with donor blood in order to remove abnormal blood components and circulating toxins while maintaining adequate circulating blood volume. OBJECTIVE: To observe the incidence, causes of jaundice requiring Exchange and any adverse event of exchange transfusion in newborns with unconjugated hyperbilirubinemia. METHOD: Prospective study undertaken at Neonatal Intensive Care Unit (NICU) of Manipal Teaching Hospital, Pokhara, Nepal from March 2014 to April 2015...
April 2015: Kathmandu University Medical Journal (KUMJ)
Jianhui Song, Gregory-Neal Gomes, Claudiu C Gradinaru, Hue Sun Chan
Single-molecule Förster resonance energy transfer (smFRET) is an important tool for studying disordered proteins. It is commonly utilized to infer structural properties of conformational ensembles by matching experimental average energy transfer ⟨E⟩exp with simulated ⟨E⟩sim computed from the distribution of end-to-end distances in polymer models. Toward delineating the physical basis of such interpretative approaches, we conduct extensive sampling of coarse-grained protein chains with excluded volume to determine the distribution of end-to-end distances conditioned upon given values of radius of gyration Rg and asphericity A...
December 10, 2015: Journal of Physical Chemistry. B
Abdul Baquee Ahmed, Lila Kanta Nath
OBJECTIVES: The purpose of the study was to develop a floating matrix tablet of Nicorandil using blends of hydrophilic cellulose and pH-independent acrylic polymer to improve the therapeutic effectiveness of the drug in cardiovascular disease. METHODS: Nicorandil tablets were prepared by direct compression and evaluated for drug-excipients compatibility, in-vitro buoyancy and in-vivo γ-scintigraphy study. The selected formulation (FT5) was also evaluated for stability study and the in-vivo absorption in rabbits to compare the pharmacokinetic parameters with the commercially available immediate release tablet of Nicorandil...
2016: Expert Opinion on Drug Delivery
Joanne C G Tan, Nicola J Armstrong, Fang Fang Yuan, Robert L Flower, Wayne B Dyer
BACKGROUND: Regular plasma donors who produce high titre anti-D immunoglobulin (Ig) are overseen by the Australian Red Cross Blood Service RhD Program. New donors to the program are immunised with small amounts of RhD-positive RBCs, whilst donors who have developed anti-D due to previous RhD-incompatible blood transfusion or pregnancy are boosted with RhD-positive RBCs to maintain a high level of serum anti-D Ig. A significant proportion of primarily immunised individuals do not respond to RhD immunisation and are therefore unnecessarily exposed to the risks involved in RBC sensitisation...
December 2015: Molecular Immunology
Jie Lu, Jonas Dimroth, Marcus Weck
In Nature, incompatible catalytic transformations are being carried out simultaneously through compartmentalization that allows for the combination of incompatible catalysts in tandem reactions. Herein, we take the compartmentalization concept to the synthetic realm and present an approach that allows two incompatible transition metal catalyzed transformations to proceed in one pot in tandem. The key is the site isolation of both catalysts through compartmentalization using a core-shell micellar support in an aqueous environment...
October 14, 2015: Journal of the American Chemical Society
Serena Valsami, Dimitrios Dimitroulis, Argyri Gialeraki, Maria Chimonidou, Marianna Politou
Platelet transfusions have contributed to the revolutionary modern treatment of hypoproliferative thrombocytopenia. Despite the long-term application of platelet transfusion in therapeutics, all aspects of their optimal use (i.e., in cases of ABO and/or Rh (D incompatibility) have not been definitively determined yet. We reviewed the available data on transfusion practices and outcome in ABO and RhD incompatibility and platelet refractoriness due to anti-human leukocyte antigen (HLA) antibodies. Transfusion of platelets with major ABO-incompatibility is related to reduced posttransfusion platelet (PLT) count increments, compared to ABO-identical and minor, but still are equally effective in preventing clinical bleeding...
July 2015: Asian Journal of Transfusion Science
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