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https://www.readbyqxmd.com/read/10997961/natural-killer-type-receptors-for-hla-class-i-antigens-are-clonally-expressed-in-lymphoproliferative-disorders-of-natural-killer-and-t-cell-type
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T Hoffmann, G De Libero, M Colonna, A Wodnar-Filipowicz, J Passweg, G Favre, A Gratwohl, A Tichelli
In recent years, natural killer (NK) cells, as well as subpopulations of T cells, have been found to express diverse NK receptors (NKRs) for HLA class I molecules. We have characterized NKR phenotypes in lymphoproliferative disorders of NK or T-cell type. Peripheral blood of patients with lymphoproliferative disorders (n = 9) was analysed by multiparametric immunofluorescence flow cytometry with eight different antibodies against NKRs. Abnormal neoplastic cell populations from different types of NK or T-cell lymphoproliferative disorders lacked diversity in their NKR repertoires, i...
September 2000: British Journal of Haematology
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