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https://www.readbyqxmd.com/read/29351550/differential-actions-of-ppar-%C3%AE-and-ppar-%C3%AE-%C3%AE-on-beige-adipocyte-formation-a-study-in-the-subcutaneous-white-adipose-tissue-of-obese-male-mice
#1
Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello
BACKGROUND AND AIMS: Obesity compromises adipocyte physiology. PPARs are essential to adipocyte plasticity, but its isolated role in the browning phenomenon is not clear. This study aimed to examine whether activation of PPAR-α or PPAR-β/δ could induce beige cell depots in the subcutaneous white adipose tissue of diet-induced obese mice. MATERIAL AND METHODS: Sixty animals were randomly assigned to receive a control diet (C, 10% lipids) or a high-fat diet (HF, 50% lipids) for ten weeks...
2018: PloS One
https://www.readbyqxmd.com/read/29350007/-the-metabolic-profilings-study-of-serum-and-spinal-cord-from-acute-spinal-cord-injury-rats-%C3%A2-h-nmr-spectroscopy
#2
Hua-Hui Hu, Xiao-Long Huang, Ren-Fu Quan, Zong-Bao Yang, Jing-Jing Xu
OBJECTIVE: To establish the rat model of acute spinal cord injury, followed by aprimary study on this model with ¹H NMR based on metabonomics and to explore the metabonomics and biomarkers of spinal cord injury rat. METHODS: Twenty eight-week-old adult male SD rats of clean grade, with body weight of (200±10) g, were divided into sham operation group and model group in accordance with the law of random numbers, and every group had 10 rats. The rats of sham operation group were operated without damaging the spinal cord, and rats of model group were made an animal model of spinal cord incomplete injury according to the modified Allen's method...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349446/ameliorative-role-of-camel-whey-protein-and-rosuvastatin-on-induced-dyslipidemia-in-mice
#3
Nashwa Ahmed El-Shinnawy, Sahar Sobhy Abd Elhalem, Nawal Zakaria Haggag, Gamal Badr
The incidence of obesity is rapidly increasing throughout the world. Dyslipidemia is a major risk factor for a number of chronic diseases, including diabetes and cardiovascular diseases. This work presents a novel approach to study the activity of camel whey protein (WP) with antioxidant and anti-inflammatory properties as a cheap dietary protein substance extracted from camel milk to produce satiety and help in building muscles. Mice model suffering from dyslipidemia as a result of feeding on high fat-cholesterol diet for 8 weeks were administrated with either camel WP and/or rosuvastatin for 4 weeks...
January 19, 2018: Food & Function
https://www.readbyqxmd.com/read/29348715/ginseng-and-obesity
#4
REVIEW
Zhipeng Li, Geun Eog Ji
Although ginseng has been shown to have an antiobesity effect, antiobesity-related mechanisms are complex and have not been completely elucidated. In the present study, we evaluated ginseng's effects on food intake, the digestion, and absorption systems, as well as liver, adipose tissue, and skeletal muscle in order to identify the mechanisms involved. A review of previous in vitro and in vivo studies revealed that ginseng and ginsenosides can increase energy expenditure by stimulating the adenosine monophosphate-activated kinase pathway and can reduce energy intake...
January 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29348098/safety-of-fenbendazole-in-common-peafowl-pavo-cristatus
#5
Sajid Umar, Seema Abbas, Muhammad Irfan Khan, Qamarun Nisa, Muhammad Younus, Kiran Aqil, Rizwan Qayyum, Muhammad Yaqoob, Asif Ali, Muhammad Asif Yaseen, Muhammad Ali Shah
The present study was undertaken to find out the safety levels of fenbendazole in common peafowl. This bird, raised on aviaries and zoos, can be severely parasitized with Ascaridia galli (enteric worms) and Syngamus trachea (gapeworm) along with other parasitic worms. Fenbendazole is a highly effective benzimidazole-class anthelmintic in animals. The objective of this work was to provide target animal safety data in young peafowl and to demonstrate reproductive safety in adult birds. During the experimental study, diets containing fenbendazole at 0, 100, 200 and 300 ppm were fed for 21 days (three times the normal treatment duration)...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29346035/determination-of-105-antibiotic-anti-inflammatory-antiparasitic-agents-and-tranquilizers-by-lc-ms-ms-based-on-an-acidic-quechers-like-extraction
#6
Aurélien Desmarchelier, Kaïli Fan, Mai Minh Tien, Marie-Claude Savoy, Adrienne Tarres, Denis Fuger, Alexandre Goyon, Thomas Bessaire, Pascal Mottier
A procedure for screening 105 veterinary drugs in foods by liquid chromatography tandem mass-spectrometry (LC-MS/MS) is presented. Its scope encompasses raw materials of animal origin (milk, meat, fish, egg and fat) but also related processed ingredients and finished products commonly used and manufactured by food business operators. Due to the complexity of the matrices considered and to efficiently deal with losses during extraction and matrix effects during MS source ionisation, each sample was analyzed twice, that is "unspiked" and "spiked at the screening target concentration" using a QuEChERS-like extraction...
January 18, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29342874/rodent-models-of-alcoholic-liver-disease-role-of-binge-ethanol-administration
#7
REVIEW
Shubha Ghosh Dastidar, Jeffrey B Warner, Dennis R Warner, Craig J McClain, Irina A Kirpich
Both chronic and acute (binge) alcohol drinking are important health and economic concerns worldwide and prominent risk factors for the development of alcoholic liver disease (ALD). There are no FDA-approved medications to prevent or to treat any stage of ALD. Therefore, discovery of novel therapeutic strategies remains a critical need for patients with ALD. Relevant experimental animal models that simulate human drinking patterns and mimic the spectrum and severity of alcohol-induced liver pathology in humans are critical to our ability to identify new mechanisms and therapeutic targets...
January 13, 2018: Biomolecules
https://www.readbyqxmd.com/read/29342166/effects-of-vitamin-d-on-insulin-resistance-and-myosteatosis-in-diet-induced-obese-mice
#8
Elisa Benetti, Raffaella Mastrocola, Fausto Chiazza, Debora Nigro, Giuseppe D'Antona, Valentina Bordano, Roberto Fantozzi, Manuela Aragno, Massimo Collino, Marco Alessandro Minetto
Epidemiological studies pointed out to a strong association between vitamin D deficiency and type 2 diabetes prevalence. However, the role of vitamin D supplementation in the skeletal muscle, a tissue that play a crucial role in the maintenance of glucose homeostasis, has been scarcely investigated so far. On this basis, this study aimed to evaluate the effect of vitamin D supplementation in a murine model of diet-induced insulin resistance with particular attention to the effects evoked on the skeletal muscle...
2018: PloS One
https://www.readbyqxmd.com/read/29341825/a-predictive-model-of-rats-calorie-intake-as-a-function-of-diet-energy-density
#9
Rahmatollah Beheshti, Yada Treesukosol, Takeru Igusa, Timothy H Moran
Easy access to high-energy food has been linked to high rates of obesity in the world. Understanding the way that access to palatable (high fat or high calorie) food can lead to overconsumption is essential for both preventing and treating obesity. Although the body of studies focused on the effects of high energy diets is growing, our understanding of how different factors contribute to food choices is not complete. In this study, we present a mathematical model that can predict rats' calorie intake to a high-energy diet based on their ingestive behavior to a standard chow diet...
January 17, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29341193/impact-of-trans-fats-on-heat-shock-protein-expression-and-the-gut-microbiota-profile-of-mice
#10
Gessika Cristina Borges Castro Carvalho, Carolina Soares Moura, Aline Rissetti Roquetto, Daniel Barrera-Arellano, Aureo Tatsumi Yamada, Andrey Dos Santos, Mário José Abdalla Saad, Jaime Amaya-Farfan
Partially hydrogenated oils are known to cause metabolic stress and dyslipidemia. This paper explores a new dimension about the interaction between dietary trans-fats and the defense heat-shock protein (HSP) system, inflammation, and the gut microbiota of mice consuming a hyperlipidic diet containing partially hydrogenated vegetable oil free of animal fat. Five diet groups were installed: control diet, 2 hyperlipidic-partially hydrogenated-oil diets, each containing either casein or whey-protein hydrolysate (WPH) as protein source, and 2 consuming hyperlipidic-unhydrogenated-oil diets containing either WPH or casein as a protein source...
January 17, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29341013/rodent-abdominal-adipose-tissue-imaging-by-mr
#11
Bhanu Prakash Kn, Jadegoud Yaligar, Sanjay K Verma, Venkatesh Gopalan, S Sendhil Velan
Rodents including rats and mice are important models to study obesity, diabetes, and metabolic syndrome in a preclinical setting. Translational and longitudinal imaging of these rodents permit investigation of metabolic diseases and identification of imaging biomarkers suitable for clinical translation. Here we describe the imaging protocols for achieving quantitative abdominal imaging in small animals followed by segmentation and quantification of fat volumes.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29337886/mechanical-activation-of-adipose-tissue-and-derived-mesenchymal-stem-cells-novel-anti-inflammatory-properties
#12
Stephana Carelli, Mattia Colli, Valeriano Vinci, Fabio Caviggioli, Marco Klinger, Alfredo Gorio
The adipose tissue is a source of inflammatory proteins, such as TNF, IL-6, and CXCL8. Most of their production occurs in macrophages that act as scavengers of dying adipocytes. The application of an orbital mechanical force for 6-10 min at 97 g to the adipose tissue, lipoaspirated and treated according to Coleman procedures, abolishes the expression of TNF-α and stimulates the expression of the anti-inflammatory protein TNF-stimulated gene-6 (TSG-6). This protein had protective and anti-inflammatory effects when applied to animal models of rheumatic diseases...
January 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29336260/adipocytes-and-abdominal-aortic-aneurysm-putative-potential-role-of-adipocytes-in-the-process-of-aaa-development
#13
Hirona Kugo, Tatsuya Moriyama, Nobuhiro Zaima
Background Adipose tissue plays a role in the storage of excess energy as triglycerides (TGs). Excess fat accumulation causes various metabolic and cardiovascular diseases. It has been reported that ectopic fat deposition and excess TG accumulation in non-adipose tissue might be important predictors of cardiometabolic and vascular risk. For example, ectopic fat in perivascular tissue promotes atherosclerotic plaque formation in the arterial wall. Objective Recently, it has been reported that ectopic fat (adipocyte) in the vascular wall of an abdominal aortic aneurysm (AAA) is present in both human and experimental animal models...
January 15, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29336053/specific-modulation-of-vertebral-marrow-adipose-tissue-by-physical-activity
#14
Daniel L Belavy, Matthew J Quittner, Nicola D Ridgers, Adnan Shiekh, Timo Rantalainen, Guy Trudel
Marrow adipose tissue (MAT) accumulation with normal aging impacts the bone, hemopoiesis, and metabolic pathways. We investigated whether exercise was associated with lower MAT, as measured by vertebral marrow fat fraction (VFF) on magnetic resonance imaging. A total of 101 healthy individuals (54 females) aged 25 to 35 years without spine or bone disease but with distinct exercise histories were studied. Long-distance runners (67 km/wk, n = 25) exhibited lower mean lumbar VFF (27.9% [8.6%] versus 33...
January 16, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29334718/-diet-and-nutrition-interventions-prevent-gestational-diabetes-mellitus
#15
Z Y Yang
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, with rising trend over the years. Dietary nutrient intake (protein, fat and fatty acids, carbohydrate, vitamin D, vitamin E, iron, zinc, selenium and inositol et al.), dietary pattern and probiotics may be related to GDM occurrence. Dietary factors are modifiable factors for preventing GDM. The study reviewed the roles of these dietary factors in preventing GDM. Results showed that plant-based dietary pattern may lower the risk of GDM and dietary pattern characterized with high animal protein, high fat and low carbohydrate may increase the risk of GDM...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334694/home-alone-a-systematic-review-and-meta-analysis-on-the-effects-of-individual-housing-on-body-weight-food-intake-and-visceral-fat-mass-in-rodents
#16
REVIEW
L Schipper, L Harvey, E M van der Beek, G van Dijk
Rats and mice are widely used to study environmental effects on psychological and metabolic health. Study designs differ widely and are often characterized by varying (social) housing conditions. In itself, housing has a profound influence on physiology and behaviour of rodents, affecting energy balance and sustainable metabolic health. However, evidence for potential long-term consequences of individual versus social housing on body weight and metabolic phenotype is inconsistent. We conducted a systematic literature review and meta-analyses assessing effects of individual versus social housing of rats and mice, living under well-accepted laboratory conditions, on measures of metabolic health, including body weight, food intake and visceral adipose tissue mass...
January 15, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29330372/non-estrogenic-xanthohumol-derivatives-mitigate-insulin-resistance-and-cognitive-impairment-in-high-fat-diet-induced-obese-mice
#17
Cristobal L Miranda, Lance A Johnson, Oriane de Montgolfier, Valerie D Elias, Lea S Ullrich, Joshua J Hay, Ines L Paraiso, Jaewoo Choi, Ralph L Reed, Johana S Revel, Chrissa Kioussi, Gerd Bobe, Urszula T Iwaniec, Russell T Turner, Benita S Katzenellenbogen, John A Katzenellenbogen, Paul R Blakemore, Adrian F Gombart, Claudia S Maier, Jacob Raber, Jan F Stevens
Xanthohumol (XN), a prenylated flavonoid from hops, improves dysfunctional glucose and lipid metabolism in animal models of metabolic syndrome (MetS). However, its metabolic transformation into the estrogenic metabolite, 8-prenylnaringenin (8-PN), poses a potential health concern for its use in humans. To address this concern, we evaluated two hydrogenated derivatives, α,β-dihydro-XN (DXN) and tetrahydro-XN (TXN), which showed negligible affinity for estrogen receptors α and β, and which cannot be metabolically converted into 8-PN...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329923/different-protein-composition-of-low-calorie-diet-differently-impacts-adipokine-profile-irrespective-of-weight-loss-in-overweight-and-obese-women
#18
R Mateo-Gallego, I Lamiquiz-Moneo, S Perez-Calahorra, V Marco-Benedí, A M Bea, L Baila-Rueda, M Laclaustra, J L Peñalvo, F Civeira, A Cenarro
BACKGROUND AND AIMS: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; ∼80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers. METHODS: Seventy-six women (BMI 32.8 ± 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months...
November 4, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29329806/effect-of-different-animal-fat-and-plant-oil-additives-on-physicochemical-mechanical-antimicrobial-and-antioxidant-properties-of-chitosan-films
#19
Lalehan Akyuz, Murat Kaya, Sedef Ilk, Yavuz Selim Cakmak, Asier M Salaberria, Jalel Labidi, Bahar Akyuz Yılmaz, Idris Sargin
Practical application of chitosan-essential oil blend films is limited due to the uneconomical extraction procedure of essential oils from plants. This study aimed to produce chitosan films blended with low cost and commercially available oils and fats consumed in daily human diet (olive, corn and sunflower oils, butter and animal fats). The study also focused on how physicochemical, biological and mechanical properties of chitosan blend films were influenced by the incorporation of oils and fats with varying unsaturation degrees...
January 9, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29329572/socio-demographic-and-lifestyle-determinants-of-dietary-patterns-in-french-speaking-switzerland-2009-2012
#20
Pedro Marques-Vidal, Gérard Waeber, Peter Vollenweider, Idris Guessous
BACKGROUND: Food intake is a complex behaviour which can be assessed using dietary patterns. Our aim was to characterize dietary patterns and associated factors in French-speaking Switzerland. METHODS: Cross-sectional study conducted between 2009 and 2012 in the city of Lausanne, Switzerland, including 4372 participants (54% women, 57.3 ± 10.3 years). Food consumption was assessed using a validated food frequency questionnaire. Dietary patterns were assessed by principal components analysis...
January 12, 2018: BMC Public Health
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