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ADULT ONSET STILL

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https://www.readbyqxmd.com/read/29772477/depression-and-metabolic-syndrome-in-the-older-population-a-review-of-evidence
#1
REVIEW
Nikolena Repousi, Maria F Masana, Albert Sanchez-Niubo, Josep Maria Haro, Stefanos Tyrovolas
BACKGROUND: Metabolic syndrome (MetS) has been shown to be associated with depression in older adults but the results are mixed. We summarized and evaluated the association between depression and MetS in people aged 60 years or over. METHODS: Relevant published studies from January 1997 to July 2017 were identified by searching two electronic databases: PubMed/Medline and EMBASE. Observational studies were considered. RESULTS: Twelve studies were included in the systematic review...
April 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29772257/conspecific-odor-exposure-predominantly-activates-non-kisspeptin-cells-in-the-medial-nucleus-of-the-amygdala
#2
Leandro Bueno Lima, Fernanda Tais Haubenthal, Marina Augusto Silveira, Tabata Mariz Bohlen, Martin Metzger, Jose Donato, Renata Frazao
A small neuronal subpopulation in the medial nucleus of the amygdala (MeA), expressing the Kiss1 gene, is now considered an important mediator that integrates socio-sexual behavior and odor information in order to modulate the Hypothalamic-Pituitary-Gonadal (HPG) axis. Previous studies demonstrated that exogenous kisspeptin administration or selective activation of Kiss1-expressing neurons in the MeA modulates the onset of puberty, LH secretion and sexual behavior. These functions are supported by the known MeA neuronal connections...
May 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29761619/changes-in-diabetes-medication-regimens-and-glycemic-control-in-adolescents-and-young-adults-with-youth-onset-type-2-diabetes-the-search-for-diabetes-in-youth-study
#3
Cathy Anne Pinto, Jeanette M Stafford, Tongtong Wang, R Ravi Shankar, Jean M Lawrence, Grace Kim, Catherine Pihoker, Ralph B D'Agostino, Dana Dabelea
OBJECTIVE: The aim of the study was to describe recent medication patterns and changes in medication patterns and glycemic control in adolescents and young adults with incident type 2 diabetes (T2D). METHODS: Using data from the SEARCH for Diabetes in Youth Study, we conducted a cross-sectional analysis of treatments for adolescents and young adults with incident T2D in two periods (2002-2005 vs. 2008/2012), and a longitudinal analysis of medications and glycemic control for a subset with baseline and follow-up visits...
May 15, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29742054/overview-of-fever-of-unknown-origin-in-adult-and-paediatric-patients
#4
REVIEW
Luciano Attard, Marina Tadolini, Domenico Umberto De Rose, Marco Cattalini
Fever of unknown origin (FUO) can be caused by a wide group of diseases, and can include both benign and serious conditions. Since the first definition of FUO in the early 1960's, several updates to the definition, diagnostic and therapeutic approaches have been proposed. This review outlines a case report of an elderly Italian male patient with high fever and migrating arthralgia who underwent many procedures and treatments before a final diagnosis of Adult-onset Still's disease was achieved. This case report highlights the difficulties in diagnosing certain causes of FUO that requires a very high index of suspicion...
January 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29737427/serum-neurofilament-light-is-increased-in-multiple-system-atrophy-of-cerebellar-type-and-in-repeat-expansion-spinocerebellar-ataxias-a-pilot-study
#5
Carlo Wilke, Friedemann Bender, Stefanie N Hayer, Kathrin Brockmann, Ludger Schöls, Jens Kuhle, Matthis Synofzik
Blood biomarkers in degenerative ataxias are still largely missing. Here, we aimed to provide piloting proof-of-concept that serum Neurofilament light (NfL) could offer a promising peripheral blood biomarker in degenerative ataxias. Specifically, as a marker of neuronal damage, NfL might (1) help to differentiate multiple system atrophy of cerebellar type (MSA-C) from sporadic adult-onset ataxia (SAOA), and (2) show increases in repeat-expansion spinocerebellar ataxias (SCAs) which might be amenable to treatment in the future...
May 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29733534/adult-onset-still-s-disease-initially-thought-to-be-an-odontogenic-infection-a-case-report
#6
Shunsuke Hino, Satoshi Nakamura, Takahiro Kaneko, Norio Horie, Tetsuo Shimoyama
OBJECTIVE: To present a case of Adult-onset Still's disease (AOSD) initially suspected to be odontogenic inflammation. BACKGROUND: Adult-onset Still's disease is a rare, complex autoinflammatory disease and a known cause of fever of unknown origin. MATERIALS AND METHODS: The patient had both a fever and dental pain. Following meticulous examination, the patient was diagnosed with AOSD. CONCLUSION: Clinicians should keep in mind that a patient such as AOSD may visit their clinics...
June 2018: Gerodontology
https://www.readbyqxmd.com/read/29731191/-intra-cardiac-manifestation-during-adult-onset-still-s-disease-s-a-tricuspid-vegetation-as-a-rare-expression-of-systemic-disease
#7
Q Quelven, B Cador, M Poinot, E Fletcher, E Le Mouel, P Jego
INTRODUCTION: Adult-onset Still's Disease is a rare multisystemic inflammatory disease characterized by fever, maculo-papular erythematous rash and arthralgia. Adult-onset Still's disease is a diagnosis of exclusion. CASE REPORT: We report the case of a 33 years old man, hospitalized for fever, arthralgia and throat manifestations, leading to Adult-onset Stills's Disease diagnosis. Cardiac ultrasound revealed tricuspid vegetation. Once infectious causes were ruled out, the vegetation was related to Adult-onset Still's Disease according to Fautrel and Yamaguchi criteria...
May 3, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29729254/physical-exercise-reserved-amyloid-beta-induced-brain-dysfunctions-by-regulating-hippocampal-neurogenesis-and-inflammatory-response-via-mapk-signaling
#8
Li-Na Sun, Jin-Shun Qi, Rong Gao
Alzheimer's disease (AD) is one of the leading causes of dementia that induced by aggregation of amyloid-beta (Aβ) in brain tissue. With high structural and functional plasticity, hippocampus plays fundamental roles in cognitive regulation. Moreover, impaired hippocampal functions present during early onset of AD. Hence, targeting on improving hippocampal plasticity would be recognized as the effective strategy in AD therapy. Physical exercise is widely encouraged healthy life style. However, whether exercise could reserve the neural dysfunctions in AD model and the possible neurobiological mechanism still need for better understanding...
May 2, 2018: Brain Research
https://www.readbyqxmd.com/read/29723378/oral-mucosa-lesions-as-atypical-manifestation-of-adult-onset-still%C3%A2-s-disease
#9
María Lorena Brance, Eldo Luis Neffen
Adult-onset Still's disease is a systemic inflammatory disorder of unknown etiology, characterized by skin rash, spiking fever, arthralgias or arthritis, and leukocytosis. The typical skin rash is evanescent, salmon-pink, nonpruritic and maculopapular, predominantly on the extremities. It is considered one of the major Yamaguchi's criteria in adult-onset Still's disease. However, atypical skin lesions are also described. Here, a 61-year-old woman with sore throat, spiking fever, polyarthritis and evanescent salmon-pink nonpruritic maculopapular skin rash on the extremities was diagnosed with adult-onset Still's disease...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29722877/rituximab-for-induction-and-maintenance-therapy-of-granulomatosis-with-polyangiitis-a-single-centre-cohort-study-on-114-patients
#10
Xavier Puéchal, Michele Iudici, Ana Luisa Calich, Alexandre Vivot, Benjamin Terrier, Alexis Régent, Pascal Cohen, Claire Le Jeunne, Luc Mouthon, Philippe Ravaud, Loïc Guillevin
Objectives: To assess efficacy and safety of rituximab (RTX) induction and maintenance therapy for granulomatosis with polyangiitis (GPA) in a single-centre cohort study. Methods: All patients with active GPA, not enrolled in trials, who received ⩾1 RTX infusion(s) for induction were included. At remission, protocolized maintenance RTX infusions were given every 6 months for 18 months. Kaplan-Meier curves were used to estimate survival rates. Univariable analyses identified factors associated with remission failure and relapse, and Cox models retained independent predictors of relapse...
May 2, 2018: Rheumatology
https://www.readbyqxmd.com/read/29715249/acute-headache-in-the-emergency-department-is-lumbar-puncture-still-necessary-to-rule-out-subarachnoid-hemorrhage
#11
Sarah Steffens, Paula Tucker, Dian Dowling Evans
The purpose of the Research to Practice column is to review current primary journal articles that directly affect the practice of the advanced practice nurse (APN) in the emergency department. This review examines the findings of Carpenter et al. (2016) from their article, "Spontaneous Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis Describing the Diagnostic Accuracy of History, Physical Exam, Imaging, and Lumbar Puncture With an Exploration of Test Thresholds." The authors concluded that although no history or physical examination finding can be used to rule in or rule out spontaneous subarachnoid hemorrhage (SAH), the complaint of neck stiffness can increase the likelihood of SAH...
April 2018: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29689421/immune-system-and-obsessive-compulsive-disorder
#12
REVIEW
Donatella Marazziti, Federico Mucci, Leonardo F Fontenelle
BACKGROUND: Recently, much attention has been devoted to the possible alterations of the immune system in obsessive-compulsive disorder (OCD). Therefore, the aim of this paper was to review the current literature on the relationships between OCD and immune system. METHODS: A PubMed and Google Scholar search was performed with specific keywords. RESULTS: In the childhood, much emphasis has been given to the relationship between group A Streptococcus (GAS) infection and the development of a group of clinical syndromes characterized by neuropsychiatric symptoms known as "pediatric autoimmune neuropsychiatric disorders associated with streptococcus" (PANDAS)...
April 13, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#13
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
April 19, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29682999/age-of-cannabis-use-onset-and-adult-drug-abuse-symptoms-a-prospective-study-of-common-risk-factors-and-indirect-effects
#14
Charlie Rioux, Natalie Castellanos-Ryan, Sophie Parent, Frank Vitaro, Richard Ernest Tremblay, Jean Richard Séguin
The present study examined 1) whether the associations between cannabis use (CU) age of onset and drug abuse by 28 y remain when controlling for risk factors in childhood, adolescence and early adulthood; and 2) the developmental pathways from early risk factors to drug abuse problems. Participants from a longitudinal sample of boys of low socioeconomic status ( N = 1,030) were followed from 6 to 28 y. We examined the self-reported CU onset between the ages of 13 and 17 y and drug abuse symptoms by 28 y. The odds of developing any drug abuse symptoms by 28 y were reduced by 31% for each year of delayed CU onset (OR = 0...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/29660063/five-successful-pregnancies-with-antenatal-anakinra-exposure
#15
Chelsey J F Smith, Christina D Chambers
Objectives: Our aim is to add to the limited existing prospective data on IL-1 inhibitor use in pregnancy. Methods: Data were obtained from the Organization of Teratology Information Specialists Autoimmune Disease in Pregnancy Project, a prospective cohort study of pregnancy outcomes in the USA and Canada. Eligible women were enrolled prior to 19 weeks' gestation between 2004 and 2017. Outcomes were obtained by maternal interview and medical record abstraction. Results: Five pregnancies with anakinra exposure were identified, all resulting in full-term singleton live births with no major or long-term complications...
April 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29658384/complications-of-adult-onset-still-s-disease-and-their-management
#16
Stéphane Mitrovic, Bruno Fautrel
Adult-onset Still's disease (AOSD) is a rare systemic auto-inflammatory disorder in which management and treatment have considerably progressed over the past decade. Despite wide use of interleukin (IL)-1 or IL-6 inhibitors, serious complications remain possible. Areas covered: A comprehensive literature search in MEDLINE via Pubmed was performed to review AOSD's severe and sometimes life-threatening complications: reactive hemophagocytic lymphohystiocytosis, coagulation disorders, fulminant hepatitis, cardiac or pulmonary complications and amyloid A amyloidosis...
April 26, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29657144/macrophage-activation-syndrome-in-patients-affected-by-adult-onset-still-disease-analysis-of-survival-rates-and-predictive-factors-in-the-gruppo-italiano-di-ricerca-in-reumatologia-clinica-e-sperimentale-cohort
#17
Piero Ruscitti, Daniela Iacono, Francesco Ciccia, Giacomo Emmi, Paola Cipriani, Rosa Daniela Grembiale, Federico Perosa, Lorenzo Emmi, Giovanni Triolo, Roberto Giacomelli, Gabriele Valentini
OBJECTIVE: Macrophage activation syndrome (MAS) is a reactive form of hemophagocytic lymphohistiocytosis, which can complicate adult-onset Still disease (AOSD). We investigated AOSD clinical features at the time of diagnosis, to assess predictors of MAS occurrence. Further, we analyzed the outcomes of patients with AOSD who experience MAS. METHODS: Patients with AOSD admitted to any Gruppo Italiano di Ricerca in Reumatologia Clinica e Sperimentale center were retrospectively analyzed for features typical of AOSD, MAS occurrence, and their survival rate...
April 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29656361/characterization-of-the-mitochondrial-aerobic-metabolism-in-the-pre-and-perisynaptic-districts-of-the-sod1-g93a-mouse-model-of-amyotrophic-lateral-sclerosis
#18
Silvia Ravera, Tiziana Bonifacino, Martina Bartolucci, Marco Milanese, Elena Gallia, Francesca Provenzano, Katia Cortese, Isabella Panfoli, Giambattista Bonanno
Amyotrophic lateral sclerosis (ALS) is an adult-onset fatal neurodegenerative disease characterized by muscle wasting, weakness, and spasticity due to a progressive degeneration of cortical, brainstem, and spinal motor neurons. The etiopathological causes are still largely obscure, although astrocytes definitely play a role in neuronal damage. Several mechanisms have been proposed to concur to neurodegeneration in ALS, including mitochondrial dysfunction. We have previously shown profound modifications of glutamate release and presynaptic plasticity in the spinal cord of the SOD1 G93A mouse model of ALS...
April 14, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29651907/evidence-based-clinical-practice-guideline-for-adult-still-s-disease
#19
Toshihide Mimura, Yuya Kondo, Akihide Ohta, Masahiro Iwamoto, Akiko Ota, Nami Okamoto, Yasushi Kawaguchi, Hajime Kono, Yoshinari Takasaki, Shuji Takei, Norihiro Nishimoto, Manabu Fujimoto, Yu Funakubo Asanuma, Akio Mimori, Naoko Okiyama, Shunta Kaneko, Hiroyuki Takahashi, Masahiro Yokosawa, Takayuki Sumida
OBJECTIVES: Using an expert- and data-driven methodology, we have constructed the first clinical practice guidelines (CPG) for adult Still's disease (ASD) after complete systematic review (SR) of the literature based upon the Medical Information Network Distribution Service (Minds) procedure. METHODS: The CPG committee for ASD organized by the Research Team for Autoimmune Diseases, the Research Program for Intractable Disease of the Japanese Ministry of Health, Labour, and Welfare has developed CPG for ASD 2017, according to the procedure proposed by Minds...
April 13, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29644168/pelvic-fracture-urethral-injury-in-males-mechanisms-of-injury-management-options-and-outcomes
#20
REVIEW
Rachel C Barratt, Jason Bernard, Anthony R Mundy, Tamsin J Greenwell
Pelvic fracture urethral injury (PFUI) management in male adults and children is controversial. The jury is still out on the best way to manage these injuries in the short and long-term to minimise complications and optimise outcomes. There is also little in the urological literature about pelvic fractures themselves, their causes, grading systems, associated injuries and the mechanism of PFUI. A review of pelvic fracture and male PFUI literature since 1757 was performed to determine pelvic fracture classification, associated injuries and, PFUI classification and management...
March 2018: Translational Andrology and Urology
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