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https://www.readbyqxmd.com/read/28738373/neuroprogression-in-schizophrenia-and-psychotic-disorders-the-possible-role-of-inflammation
#1
Norbert Müller
Schizophrenia is a disorder that shows a progressive course in 30-50% of the people concerned. The biology of chronification and progression is unclear. Genetic aspects may play a role, but details are unresolved. The fact that immune-mediated and autoimmune disorders such as rheumatoid arthritis or multiple sclerosis have a very similar course as schizophrenia has focused the interest on the immunopathogenesis of schizophrenia. A clear immune marker for neuroprogression in schizophrenia or psychosis could not be identified up to now, but a proinflammatory immune state (increased markers of cellular immunity) is regularly found in schizophrenia, e...
July 24, 2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28738102/anti-nmda-receptor-encephalitis-presenting-as-a-primary-psychotic-disorder
#2
Michele A Nelson, Jeannie D Lochhead, Gerald A Maguire
No abstract text is available yet for this article.
August 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28725312/two-cases-of-pneumatosis-cystoides-intestinalis-with-intraperitoneal-free-air
#3
Kensuke Wada, Nobuhiro Takeuchi, Masakazu Emori, Masanori Takada, Yusuke Nomura, Akihito Otsuka
Intraperitoneal free air (IFA) is sometimes accompanied by pneumatosis cystoides intestinalis (PCI); therefore, proper diagnosis is essential for PCI management. We report two cases of PCI with IFA. A 70-year-old female taking anti-psychotic medication for schizophrenia presented with repeated vomiting and high-grade fever. Computed tomography revealed small, linear gaseous cysts in the intestinal wall along with IFA. Although there was no sign of peritoneal irritation, intestinal perforation was not excluded...
June 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28713269/the-emerging-role-for-zinc-in-depression-and-psychosis
#4
REVIEW
Matthew A Petrilli, Thorsten M Kranz, Karine Kleinhaus, Peter Joe, Mara Getz, Porsha Johnson, Moses V Chao, Dolores Malaspina
Zinc participation is essential for all physiological systems, including neural functioning, where it participates in a myriad of cellular processes. Converging clinical, molecular, and genetic discoveries illuminate key roles for zinc homeostasis in association with clinical depression and psychosis which are not yet well appreciated at the clinical interface. Intracellular deficiency may arise from low circulating zinc levels due to dietary insufficiency, or impaired absorption from aging or medical conditions, including alcoholism...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28650064/-a-new-case-of-psychotic-break-as-the-presenting-symptom-of-anti-nmda-receptor-encephalitis-treatment-from-a-neuropsychiatric-approach
#5
P Hernaez-Goni, P Luna-Lario, J Tirapu-Ustarroz
INTRODUCTION: Limbic encephalitis generated by anti-N-methyl D-aspartate (NMDA) receptor antibodies is a severe acute neurological condition that is more prevalent in young females and is associated with an underlying tumour. The appearance of severe initial psychiatric signs and symptoms and the fact that it is accompanied by emotional disorders and severe cognitive impairment make it necessary to reconsider the contributions of neuropsychiatry to the diagnosis, development and treatment of the disease, since these have received little attention from researchers to date...
July 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28647179/euphorbia-neriifolia-l-review-on-botany-ethnomedicinal-uses-phytochemistry-and-biological-activities
#6
REVIEW
Prashant Y Mali, Shital S Panchal
The present review is intended to provide information on botany, ethnomedicinal uses, phytochemistry and biological activities of various parts of Euphorbia neriifolia (E. neriifolia). E. neriifolia has several ethnomedicinal uses. The latex of E. neriifolia is used as laxative, purgative, rubefacient, carminative and expectorant as well as in treatment of whooping cough, gonorrhoea, leprosy, asthma, dyspepsia, jaundice, enlargement of the spleen, tumours, stone in the bladder, abdominal troubles and leucoderma...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28596687/relationship-between-use-of-selective-serotonin-reuptake-inhibitors-and-irritable-bowel-syndrome-a-population-based-cohort-study
#7
Wan-Tzu Lin, Yi-Jun Liao, Yen-Chun Peng, Chung-Hsin Chang, Ching-Heng Lin, Hong-Zen Yeh, Chi-Sen Chang
AIM: To investigate the relationship between selective serotonin reuptake inhibitor (SSRI) use and the subsequent development of irritable bowel syndrome (IBS). METHODS: This retrospective, observational, population-based cohort study collected data from Taiwan's National Health Insurance Research Database. A total of 19653 patients newly using SSRIs and 78612 patients not using SSRIs, matched by age and sex at a ratio of 1:4, were enrolled in the study from January 1, 2000 to December 31, 2010...
May 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28566948/clinical-and-autoimmune-features-of-a-patient-with-autism-spectrum-disorder-seropositive-for-anti-nmda-receptor-autoantibody
#8
Hélène Gréa, Isabelle Scheid, Alexandru Gaman, Véronique Rogemond, Sandy Gillet, Jérôme Honnorat, Federico Bolognani, Christian Czech, Céline Bouquet, Elie Toledano, Manuel Bouvard, Richard Delorme, Laurent Groc, Marion Leboyer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by dysfunctions in social interactions resulting from a complex interplay between immunogenetic and environmental risk factors. Autoimmunity has been proposed as a major etiological component of ASD. Whether specific autoantibodies directed against brain targets are involved in ASD remains an open question. Here, we identified within a cohort an ASD patient with multiple circulating autoantibodies, including the well-characterized one against glutamate NMDA receptor (NMDAR-Ab)...
March 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28560264/thought-disorder-measured-as-random-speech-structure-classifies-negative-symptoms-and-schizophrenia-diagnosis-6-months-in-advance
#9
Natália B Mota, Mauro Copelli, Sidarta Ribeiro
In chronic psychotic patients, word graph analysis shows potential as complementary psychiatric assessment. This analysis relies mostly on connectedness, a structural feature of speech that is anti-correlated with negative symptoms. Here we aimed to verify whether speech disorganization during the first clinical contact, as measured by graph connectedness, can correctly classify negative symptoms and the schizophrenia diagnosis 6 months in advance. Positive and negative syndrome scale scores and memory reports were collected from 21 patients undergoing first clinical contact for recent-onset psychosis, followed for 6 months to establish diagnosis, and compared to 21 well-matched healthy subjects...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28552049/1-4-benzothiazines-a-biologically-attractive-scaffold
#10
Amit Rai, Ashok K Singh, Vinit Raj, Sudipta Saha
1,4-benzothiazine (1,4-B), a pharmacophore of anti-psychotic drug phenothiazines, is a vital class of heterocyclic compounds implicating versatile biological activities. Among offering several interesting biological activities, 1,4-benzothiazines (1,4-Bs) have a tremendous ability to regulate diverse range of cellular pathways that can be explored for selective anticancer activity. Synthetic chemists have discovered numerous routes for the syntheses of various 1,4-B analogues that show excellent activities through multiple mechanisms...
May 28, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28539959/tardive-dystonia-related-with-aripiprazole
#11
Sunghwan Kim, Seung-Yup Lee, MinSeob Kim, Kyoung-Uk Lee
Tardive dystonia is characterized by sustained, generally slow involuntary twisting movements. It is estimated to occur at a frequency of 1% to 4% among patients who are taking an antipsychotic agent. Unlike the first generation antipsychotics, the second generation antipsychotics are less likely to cause neuroleptic-induced movement disorder. For aripiprazole, only a few cases have been reported for tardive dystonia. We present a young male, who developed a severe tardive dystonia after taking aripiprazole for 5 years...
May 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/28536567/the-repurposing-of-anti-psychotic-drugs-quetiapine-and-olanzapine-as-anti-cryptococcus-drugs
#12
Adepemi O Ogundeji, Carolina H Pohl, Olihile M Sebolai
The management of cryptococcal infections is often difficult. This can, in part, be attributed to the fungistatic nature of fluconazole, which may result in cells disseminating to give rise to pathogen-emergent psychosis following brain inflammation. This chance at treatment failure has necessitated the current study wherein the antimicrobial quality of anti-psychotic drugs viz. quetiapine and olanzapine, was assessed. The response of test strains toward quetiapine or olanzapine alone and in combined therapy with fluconazole or amphotericn B was measured...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28528230/effect-of-childhood-trauma-on-cognitive-functions-in-a-sample-of-chinese-patients-with-schizophrenia
#13
Xian-Bin Li, Qi-Jing Bo, Guang-Ping Zhang, Wei Zheng, Zhi-Min Wang, An-Ning Li, Qing Tian, Jin-Tong Liu, Yi-Lang Tang, Chuan-Yue Wang
In this study, we aimed to determine the influence of various types of childhood trauma (CT) on cognitive functions in Chinese patients presented with schizophrenia. One hundred sixty-two patients were assessed with the Childhood Trauma Questionnaire-Short Form (CTQ-SF) and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). We investigated the correlations between various types of CT, demographic characteristics, and cognitive functions. Significant negative correlations were observed in physical abuse (PA) and sexual abuse (SA) with the language score (r=-0...
July 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28499901/antioxidant-and-anti-inflammatory-nutrient-status-supplementation-and-mechanisms-in-patients-with-schizophrenia
#14
REVIEW
Sumedha Mitra, Radhika Natarajan, Douglas Ziedonis, Xiaoduo Fan
Over 50 million people around the world suffer from schizophrenia, a severe mental illness characterized by misinterpretation of reality. Although the exact causes of schizophrenia are still unknown, studies have indicated that inflammation and oxidative stress may play an important role in the etiology of the disease. Pro-inflammatory cytokines are crucial for normal central nervous development and proper functioning of neural networks and neurotransmitters. Patients with schizophrenia tend to have abnormal immune activation resulting in elevated pro-inflammatory cytokine levels, ultimately leading to functional brain impairments...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28465247/evaluation-of-the-effects-of-anti-psychotic-drugs-on-the-expression-of-cd68-on-the-peripheral-blood-monocytes-of-alzheimer-patients-with-psychotic-symptoms
#15
Reza Bahramabadi, Morteza Samadi, Alireza Vakilian, Elham Jafari, Mahmood Sheikh Fathollahi, Mohammad Kazemi Arababadi
INTRODUCTION: Previous studies approved the important roles of CD68, as scavenger receptors, in Alzheimer's disease (AD). The aim of this study was to evaluate the effect of treatment with anti-psychotic drugs and vitamin B12 on the expression levels of CD68 in monocytes of psychotic AD patients. MATERIAL AND METHODS: Expression of CD68 on the monocytes was evaluated in the following groups: 1. age and sex matched healthy controls (Group 1), 2. non-psychotic AD patients (Group 2), 3...
June 15, 2017: Life Sciences
https://www.readbyqxmd.com/read/28464848/experiences-perspectives-and-priorities-of-people-with-schizophrenia-spectrum-disorders-regarding-sleep-disturbance-and-its-treatment-a-qualitative-study
#16
Sophie Faulkner, Penny Bee
BACKGROUND: Sleep problems are very common in people with schizophrenia spectrum disorders, and impact negatively on functioning and wellbeing. Research regarding interventions to improve sleep in this population has been lacking. Little is known regarding these patient's perspectives on sleep problems and their treatment, providing very little foundation on which to develop acceptable and patient-centred treatments. METHODS: This study aims to explore perspectives and priorities of participants with schizophrenia spectrum disorders regarding sleep and sleep disturbance, and their perspectives on existing treatments...
May 2, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28463343/biological-treatment-of-acute-agitation-or-aggression-with-schizophrenia-or-bipolar-disorder-in-the-inpatient-setting
#17
Christoph U Correll, Xin Yu, Yutao Xiang, John M Kane, Prakash Masand
BACKGROUND: Schizophrenia and bipolar disorders are chronic illnesses that commonly present with symptoms of acute agitation and aggression. These symptoms must be managed rapidly to prevent potential harm to the patient and others, including their caregivers, peers, and health care workers. A number of treatment options are available to clinicians to manage acute agitation and aggression, including non-pharmacologic behavioral and environmental de-escalation strategies, as well as biological treatment options such as pharmacologic agents and electroconvulsive therapy...
May 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28462841/design-and-optimization-of-purine-derivatives-as-in-vivo-active-pde10a-inhibitors
#18
Liu Chen, Danqi Chen, Le Tang, Jing Ren, Jiaojiao Chen, Xuechu Zhen, Yu-Chih Liu, Chenhua Zhang, Haibin Luo, Jingkang Shen, Bing Xiong
Phosphodiesterases are important enzymes regulating signal transduction mediated by second messenger molecules cAMP or cGMP. PDE10A is a unique member in the PDE family because of its selective expression in medium spiny neurons. It is recognized as anti-psychotic drug target. Based on the structural similarity between our previous chemistry work on 8-aminoimidazo[1,2-a]pyrazines and the PDE10A inhibitors reported by Bartolome-Nebreda et al., we initialized a project for developing PDE10A inhibitors. After several rounds of optimization, we were able to obtain a few compounds with good PDE10A enzymatic activity...
July 1, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28454291/thioridazine-has-potent-antitumor-effects-on-lung-cancer-stem-like-cells
#19
Jiani Shen, Buyun Ma, Xinmin Zhang, Xiaozhu Sun, Jiancui Han, Yigang Wang, Liang Chu, Haineng Xu, Yu Yang
Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung cancer stem-like cells, as its effect remains unknown. TDZ was utilized to treat lung cancer stem-like cells (A549 sphere cells) and its cytotoxic effect and mechanism were evaluated in vitro and in vivo. TDZ elicited cytotoxicity in A549 sphere cells and inhibited their proliferation in a dose-dependent pattern. A549 sphere cells treated with TDZ showed nuclear fragmentation, increased G0/G1 phase distribution, positive Annexin V staining, and a change in the expression of caspase family and cell cycle-associated proteins...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28450912/effects-of-the-modified-electric-convulsive-treatment-mect-on-cell-factors-of-schizophrenia
#20
Yong-Fang Guo, Hua-Bin Fu, Zhi-Yuan Liu, Wei Lu, Ke-Yong Luo, Hong-Ri Zhu, Wei-Dong Ning, Feng Chen, Li-Yu Yang, Xiao-Dong Zhou
The expression of cell factors of schizophrenia and the effect of the modified electric convulsive treatment (MECT) were studied. In total, 156 patients with schizophrenia were selected, and divided into the drug group (70 cases) and the drug combined with MECT group (combined group) (86 cases) according to the treatment methods. In addition, 70 cases of healthy volunteers (control group) were selected according to the closest matching method based on 1:1 of age and gender. The drug treatment, consisted of anti-psychotic drugs, such as risperidone 2-8, quetiapine 300-750, ziprasidone 80-160 or aripiprazole 10-30 mg/day, and for the control group, we used the electric spasm therapeutic instrument, Thymatron(®)IV Systems up to 6 times, 3 times a week...
March 2017: Experimental and Therapeutic Medicine
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