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Lupus; hemodialysis;peritoneal dialysis; renal transplantation

Michelle M O'Shaughnessy, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND: Kidney transplantation is the preferred treatment for end-stage renal disease (ESRD), while peritoneal dialysis affords certain benefits over hemodialysis. Distributions and determinants of first ESRD treatment modality have not been compared across glomerulonephritis (GN) subtypes. METHODS: We identified all adult (18-75 years) patients with ESRD attributed to any of six GN subtypes [focal segmental glomerulosclerosis (FSGS), IgA nephropathy (IgAN), membranous nephropathy (MN), membranoproliferative GN (MPGN), lupus nephritis (LN) and vasculitis] who were first registered in the US Renal Data System (USRDS) between 1996 and 2011...
February 2016: Nephrology, Dialysis, Transplantation
Alberto J Sabucedo, Gabriel Contreras
Kidney disease resulting from systemic lupus erythematosus accounts for 1.9% of the end-stage kidney disease (ESKD) population in the United States. Systemic lupus erythematosus patients with lupus nephritis (LN) who progress to ESKD in the United States are mostly female (81%) and of African ancestry (49%), with a mean age of 41 years at initiation of renal replacement therapy (RRT). The incidence of ESKD in patients with LN steadily increased between 1982 and 1998 because RRT was offered more readily to LN patients in the United States...
September 2015: Seminars in Nephrology
M Tuğcu, Ç Ruhi, B Boynueğri, U Kasapoğlu, Ö Can, G Kiliçoğlu, G Şahin, M Titiz
Differential diagnosis of post-transplant infections should include rare/uncommon foci and pathogens. We present a rare case of life-threatening infection, a splenic abscess in a 53-year-old woman who was transplanted with a cadaveric kidney 5 months previously. The patient was admitted to our clinic with chills, shivering, and fever. She required a kidney transplant because of end-stage renal disease secondary to systemic lupus erythematosus, which had previously been treated by means of peritoneal dialysis for 7 years, until encapsulated sclerosing peritonitis developed, at which time therapy was changed to hemodialysis for 1 year...
June 2015: Transplantation Proceedings
Michelle M O'Shaughnessy, Maria E Montez-Rath, Richard A Lafayette, Wolfgang C Winkelmayer
BACKGROUND AND OBJECTIVES: Outcomes-based research rarely focuses on patients with ESRD caused by GN. The hypotheses were that the GN subtype would clinically discriminate patient groups and independently associate with survival after ESRD therapy initiation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Data were extracted from the US Renal Data System for adult patients with incident (1996-2011) ESRD attributed to six GN subtypes: FSGS, IgA nephropathy (IgAN), membranous nephropathy, membranoproliferative glomeruonephritis, lupus nephritis (LN), and vasculitis...
July 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
M-J Wu, Y-C Lo, J-L Lan, T-M Yu, K-H Shu, D-Y Chen, H-C Ho, C-H Lin, S-N Chang
BACKGROUND: Systemic lupus erythematosus (SLE) is not a rare disease among the Chinese and the incidence is higher in the female population. Lupus nephritis (LN) often develops in patients with SLE and may progress to end-stage renal disease (ESRD). Although there are studies that suggest postponement of the scheduling of kidney transplantation (KT) for these patients, there are still some other studies with conflicting results. Our study aimed to analyze the outcome of patients with LN after progression to ESRD and to try to elucidate whether deferral of KT is necessary in the Chinese population...
2014: Transplantation Proceedings
Osama El Minshawy, Tawfik Ghabrah, Eman El Bassuoni
The purpose of this study was to determine the prevalence, etiology and risk factors of treated end-stage renal disease (ESRD) in the region of Tabuk, Saudi Arabia. We studied 460 renal replacement therapy patients through a review of medical records and patient interviews and obtained patient demographics, family history, risk factors for ESRD, environmental exposure to toxins, work conditions, social history and causes of death. The estimated prevalence of treated ESRD was 460 per million populations (PMP); 350 (76%) were treated by hemodialysis, 30 (7%) by peritoneal dialysis and 80 (17%) by kidney transplantation...
January 2014: Saudi Journal of Kidney Diseases and Transplantation
C S Oliveira, I d Oliveira, A B S Bacchiega, E M Klumb, E M M Albuquerque, E Souza, J H S Suassuna, F M Ribeiro
OBJECTIVE: To determine the epidemiological profile and outcome of patients with lupus nephritis (LN) undergoing renal transplantation. METHODS: The archival records of 50 patients with LN and end-stage renal disease (ESRD) treated by kidney transplantation from March 1992 to December 2010 were reviewed. All patients met the American College of Rheumatology criteria for systemic lupus erythematosus (SLE). RESULTS: Fourteen patients were included in the study...
April 2012: Lupus
Amy Devlin, Sushrut S Waikar, Daniel H Solomon, Bing Lu, Tamara Shaykevich, Graciela S Alarcón, Wolfgang C Winkelmayer, Karen H Costenbader
OBJECTIVE: Little is known about the patterns of use of initial kidney replacement therapies among patients with lupus nephritis (LN) end-stage renal disease (ESRD). We aimed to identify sociodemographic and clinical factors associated with variation in initial kidney replacement therapies among LN ESRD patients. METHODS: Patients with incident LN ESRD (1995-2006) were identified in the US Renal Data System. Age, sex, race, ethnicity, medical insurance, employment status, residential region, clinical factors, and comorbidities were considered as potential predictors of ESRD treatment choice, i...
December 2011: Arthritis Care & Research
Osama El Minshawy
We had earlier conducted two cross-sectional studies on the epidemiology of endstage renal disease (ESRD) in the El-Minia Governorate. The aim of this study is to assess the prevalence, etiology and risk factors for ESRD in the El-Minia Governorate during the year 2006. Patients on renal replacement therapy (RRT), numbering 1356, were recruited into this study. A standardized questionnaire was completed including demographics, family history, risk factors for ESRD, environmental exposure to toxins, work conditions, social history and causes of death...
September 2011: Saudi Journal of Kidney Diseases and Transplantation
Karen H Costenbader, Amrita Desai, Graciela S Alarcón, Linda T Hiraki, Tamara Shaykevich, M Alan Brookhart, Elena Massarotti, Bing Lu, Daniel H Solomon, Wolfgang C Winkelmayer
OBJECTIVE: This study was undertaken to investigate whether recent advances in lupus nephritis treatment have led to changes in the incidence of end-stage renal disease (ESRD) secondary to lupus nephritis, or in the characteristics, treatments, and outcomes of patients with lupus nephritis ESRD. METHODS: Patients with incident lupus nephritis ESRD (1995-2006) were identified in the US Renal Data System. Trends in sociodemographic and clinical characteristics were assessed...
June 2011: Arthritis and Rheumatism
Seok-Hui Kang, Byung-Ha Chung, Sun-Ryoung Choi, Ja-Young Lee, Hoon-Suk Park, In-O Sun, Bum-Soon Choi, Cheol-Whee Park, Yong-Soo Kim, Chul-Woo Yang
BACKGROUND/AIMS: Many studies have compared patients with systemic lupus erythematosus (SLE) on renal replacement therapy (RRT) with non-lupus patients. However, few data are available on the long-term outcome of patients with end-stage renal disease (ESRD) secondary to SLE who are managed by different types of RRTs. METHODS: We conducted a retrospective multicenter study on 59 patients with ESRD who underwent maintenance RRT between 1990 and 2007 for SLE. Of these patients, 28 underwent hemodialysis (HD), 14 underwent peritoneal dialysis (PD), and 17 patients received kidney transplantation (KT)...
March 2011: Korean Journal of Internal Medicine
T Ripert, J Menard, Y Schoepen, P N'guyen, P Rieu, B Brandt, F Staerman
OBJECTIVES: Graft thrombosis is a major complication of transplantation. However, there are no recommendation on immediate postoperative thromboprophylaxis after kidney transplantation. We recorded clinical practices in France. MATERIAL AND METHODS: In 29 transplantation centres, four case studies were submitted to the medical kidney transplantation referent (compatible graft from cadaveric donor, without perioperative complication). N(o) 1: Man, 27-years-old, IgA glomerulonephritis, without history of hypercoagulability or cardiovascular risk factor...
March 2009: Progrès en Urologie
G Banfi, A Leoni, G Moroni
Approximately 10% of patients with lupus nephritis develop end-stage renal disease (ESRD). In some cases with a rapidly progressive course, treatment may result in partial recovery of renal function. The choice of aggressive treatment should be balanced against the risk of enhanced morbidity due to side effects in patients with renal insufficiency; one should therefore desist from preventing ESRD at any cost. Renal replacement therapy (both hemodialysis and peritoneal dialysis) may offer lupus patients with ESRD good chances of survival...
November 2008: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
Hongying Tang, Madhukar Chelamcharla, Bradley C Baird, Fuad S Shihab, James K Koford, Alexander S Goldfarb-Rumyantzev
BACKGROUND: Factors associated with outcome in renal transplant recipients with lupus nephritis have not been studied. METHODS: Using the data from the United States Renal Data System of patients transplanted between January 1, 1995 through December 31, 2002 (and followed through December 31, 2003) (n = 2882), we performed a retrospective analysis of factors associated with long-term death-censored graft survival and recipient survival. RESULTS: The number of pretransplant pregnancies incrementally increased the risk of graft failure [hazard ratio (HR) 1...
May 2008: Clinical Transplantation
Sharlet Slough, Karen S Servilla, Antonia M Harford, Kontantin N Konstantinov, Alexis Harris, Antonios H Tzamaloukas
The pathogenesis of calciphylaxis, which has a rising incidence in the chronic dialysis population and a high mortality rate, is poorly understood. Abnormalities in the calcium-phosphorus-parathyroid axis are clinically related to calciphylaxis, but alone, they cannot explain this condition. Here, we present two patients who had chronic inflammatory conditions and hyperparathyroidism and who developed calciphylaxis. A 41-year-old white woman on hemodialysis following scleroderma, hepatitis C, liver transplant, and failed kidney transplant, developed progressive ulcerative lower extremity calciphylaxis lasting more than 3 years...
2006: Advances in Peritoneal Dialysis
S S Wang, N K Chou, N H Chi, R B Hsu, S C Huang, Y S Chen, H Y Yu, W J Ko, S H Chu, M K Tsai, P H Lee
Simultaneous heart and kidney transplantation (SHKT) is feasible for combined cardiac and renal failure. Herein we reviewed our 10-year experience in SHKT. Six patients underwent SHKT from June 1995 to December 2004. Their ages ranged from 13 to 63 years old with a mean of 45.5 +/- 15.8 years. They were all men except one girl, who was the youngest (aged 13) who suffered from dilated cardiomyopathy with congestive heart failure and chronic renal failure due to systemic lupus erythematosus. Because of aggravating heart failure, she changed from hemodialysis to peritoneal dialysis...
September 2006: Transplantation Proceedings
Francisco Santa Cruz, Walter Cabrera, Susana Barreto, María Magdalena Mayor, Diana Báez
Paraguay is a landlocked country located in South America with a total population of 5,884,491. Most of the population (95%) is mestizo, a mixture of Spanish and American/Indian races. The total number of indigenous people in the country has increased from 38,703 in 1981 to 85,674 in 2002. The gross domestic product per capita was US $932.00 annually per person in the year 2002. Between 1992 and 1997, there were 380 patients on chronic dialysis in Paraguay and 75 patients received renal transplants, mostly living-related...
August 2005: Kidney International. Supplement
Young Suck Goo, Hyeong Cheon Park, Hoon Young Choi, Beom Seok Kim, Yong Beom Park, Soo-Kon Lee, Shin Wook Kang, Soon Il Kim, Yu Seun Kim, Ki Il Park, Ho Yung Lee, Dae Suk Han, Kyu Hun Choi
The aim of this study was to evaluate the evolution of lupus activity in end-stage renal disease (ESRD) patients due to lupus nephritis and to determine the long-term prognosis. We reviewed the clinical courses of 45 patients with ESRD due to systemic lupus erythematosus (SLE). We analyzed the course of SLE following the onset of ESRD, with special attention to the clinical and serological manifestations, survival time on dialysis, and renal transplantation outcome. Disease activity was measured using the SLE Disease Activity Index (SLEDAI)...
April 30, 2004: Yonsei Medical Journal
Shanyan Lin
Nephrological work in China started in early 60s, but it was not until the middle of the 1980s before it became an independent discipline and linked with the international nephrology community. Due to the huge population and enormous territory, nephrologists are facing a great mission and momentous challenges. Most nephrologists reside in the coastal region, which has a higher education background than most of the rest of the country. Among them, Beijing, Shanghai, Guanzhong and Nangjing are the major centers for training graduate students to conduct basic and clinical research...
February 2003: Kidney International. Supplement
Daniel P Tveit, Paul Hshieh, David Cruess, Lawrence Y C Agodoa, Paul G Welch, Kevin C Abbott
BACKGROUND: Risk factors for pulmonary embolism (PE) in end stage renal disease (ESRD) patients have not been studied in a large population. METHODS: 375,152 patients in the United States Renal Data System initiated on dialysis between 1 January 1992 and 30 June 1997 were analyzed in an historical cohort study of hospitalized PE (ICD9 Code 415.1x) occurring prior to receipt of renal transplant. Cox regression models were used to analyze risk factors for PE in dialysis...
May 2002: Journal of Nephrology
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