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Bacterial prostatitis

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https://www.readbyqxmd.com/read/28053947/anti-inflammatory-and-antimicrobial-effects-of-a-novel-herbal-formulation-wsy-1075-in-a-chronic-bacterial-prostatitis-rat-model
#1
Jung Woo Park, Hyun Cheol Jeong, Hyong Woo Moon, Shin Jay Cho, Jong Hyup Yang, Woo Hyun Kim, Woong Jin Bae, Jin Bong Choi, Hyuk Jin Cho, U-Syn Ha, Sung Hoo Hong, Ji Youl Lee, Sae Woong Kim
PURPOSE: The aim of this study was to investigate the anti-inflammatory and anti-oxidative effects of a multi-herbal formula known as WSY-1075 in the treatment of chronic bacterial prostatitis in a rat model. MATERIALS AND METHODS: Experimental chronic bacterial prostatitis was induced in 32 Wistar rats by instillation of a bacterial suspension (Escherichia coli, 10(8) colony-forming units [CFU]/mL) into the prostatic urethra. After the induction of prostatitis, the rats were randomly divided into one of 4 treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (400 mg/kg) (n=8), and WSY-1075 (400 mg/kg)+ciprofloxacin (n=8)...
December 2016: World Journal of Men's Health
https://www.readbyqxmd.com/read/28017697/anti-inflammatory-and-antioxidant-effect-of-modified-bazhengsan-in-a-rat-model-of-chronic-bacterial-prostatitis
#2
Youyi Xiong, Xingtao Qiu, Weijing Shi, Hao Yu, Xiaolin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Bazhengsan is a commonly used traditional Chinese prescription for the treatment of the urogenital system diseases for thousands of years, which decoction was first described in Prescriptions of the Bureau of Taiping People's Welfare Pharmacy in Song Dynasty. AIM OF THE STUDY: In this study, the potential of modified Bazhengsan (mBazhengsan) as a chronic bacterial prostate inflammation inhibitor was investigated in a rat model. MATERIALS AND METHODS: Rat prostates were injected with Escherichia coli to induce inflammation by the sterile operation...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27991763/the-pepsavi-ms-pipeline-for-natural-product-bioactive-peptide-discovery
#3
Christine L Kirkpatrick, Christopher A Broberg, Elijah N McCool, Woo Jean Lee, Alex Chao, Evan W McConnell, David Pritchard, Michael Hebert, Renee Fleeman, Jessie Adams, Amer Jamil, Laurence Madera, Adam A Strömstedt, Ulf Goransson, Yufeng Liu, David W Hoskin, Lindsey N Shaw, Leslie M Hicks
The recent increase in extensively drug resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide discovery. This highly versatile platform employs mass spectrometry and statistics to identify bioactive peptide targets from complex biological samples. We validate the use of this platform through the successful identification of known bioactive peptides from a botanical species, Viola odorata...
December 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27943679/alternative-synthesis-route-of-biocompatible-polyvinylpyrrolidone-nanoparticles-and-their-effect-on-pathogenic-microorganisms
#4
Vedran Milosavljevic, Pavlina Jelinkova, Ana Maria Jimenez Jimenez, Amitava Moulick, Yazan Haddad, Hana Buchtelova, Sona Krizkova, Zbynek Heger, Lukas Kalina, Lukas Richtera, Pavel Kopel, Vojtech Adam
Herein we describe a novel alternative synthesis route of polyvinylpyrrolidone nanoparticles using salting-out method at a temperature close to polyvinylpyrrolidone decomposition. At elevated temperatures, the stability of polyvinylpyrrolidone decreases and the opening of pyrrolidone ring fractions occurs. This leads to cross-linking process, where separate units of polyvinylpyrrolidone interact among themselves and rearrange to form nanoparticles. The formation/stability of these nanoparticles was confirmed by transmission electron microscopy, X-ray photoelectron spectroscopy, mass spectrometry, infrared spectroscopy, and spectrophotometry...
January 3, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27923372/community-acquired-meningitis-caused-by-a-cg86-hypervirulent-klebsiella-pneumoniae-strain-first-case-report-in-the-caribbean
#5
Bénédicte Melot, Sylvain Brisse, Sébastien Breurec, Virginie Passet, Edith Malpote, Isabelle Lamaury, Guillaume Thiery, Bruno Hoen
BACKGROUND: Community-acquired bacterial meningitis due to Klebsiella pneumoniae has mainly been described in Southeast Asia and has a poor prognosis. Severe invasive infections caused by K. pneumoniae, including meningitis, are often due to hypervirulent strains (hvKP), which are characterized by capsular serotypes K1 and K2, a gene responsible for hypermucoviscosity, and the cluster for synthesis of the siderophore aerobactin. CASE PRESENTATION: A 55 year old man with a history of essential hypertension, benign prostate hyperplasia, hyperlipidemia, obstructive sleep apnea, and chronic alcoholism was admitted for meningitis due to Klebsiella pneumoniae with a wild-type susceptibility profile...
December 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27916925/microbial-biofilms-in-urinary-tract-infections-and-prostatitis-etiology-pathogenicity-and-combating-strategies
#6
REVIEW
Cristina Delcaru, Ionela Alexandru, Paulina Podgoreanu, Mirela Grosu, Elisabeth Stavropoulos, Mariana Carmen Chifiriuc, Veronica Lazar
Urinary tract infections (UTIs) are one of the most important causes of morbidity and health care spending affecting persons of all ages. Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. UTIs associated with microbial biofilms developed on catheters account for a high percentage of all nosocomial infections and are the most common source of Gram-negative bacteremia in hospitalized patients. The purpose of this mini-review is to present the role of microbial biofilms in the etiology of female UTI and different male prostatitis syndromes, their consequences, as well as the challenges for therapy...
November 30, 2016: Pathogens
https://www.readbyqxmd.com/read/27891339/bacteriological-profile-of-isolates-from-urine-samples-in-patients-of-benign-prostatic-hyperplasia-and-or-prostatitis-showing-lower-urinary-tract-symptoms
#7
Prem Prakash Mishra, Ved Prakash, Kashmir Singh, H Mog, Sumit Agarwal
INTRODUCTION: The incidence of Benign Prostatic Hyperplasia (BPH) or Prostatitis is increasing considerably worldwide. The Lower Urinary Tract Symptoms (LUTS) due to bacterial aetiology are one of the common factors for the complications among the patients. AIM: To determine the bacterial agents and their antibiotic sensitivity pattern from the urine samples of patients of BPH or Prostatitis showing symptoms of LUTS. MATERIALS AND METHODS: The cross-sectional study was carried out in the Department of Microbiology of Rohilkhand Medical College and Hospital of Northern India from June 2014 to May 2015...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27843267/bacteriology-of-urine-specimens-obtained-from-men-with-symptomatic-benign-prostatic-hyperplasia
#8
Jude Orumuah Agbugui, E O Obarisiagbon, I I Osaigbovo
BACKGROUND: Bacteriuria and urinary tract infections are common sequelae of benign prostatic hyperplasia (BPH). Thus, the knowledge of urine bacteriology in men with symptomatic BPH in our environment may play a complementary role in management. OBJECTIVES: To determine the incidence of bacteriuria and the antibiotic sensitivity pattern of bacterial isolates in cultured urine samples of men with symptomatic BPH. PATIENTS AND METHODS: This was a 1 year prospective study...
July 2016: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/27831506/causes-of-death-among-cancer-patients
#9
N G Zaorsky, T M Churilla, B L Egleston, S G Fisher, J A Ridge, E M Horwitz, Je Meyer Md
BACKGROUND: The purpose of our study was to characterize the causes of death among cancer patients as a function of objectives: (I) calendar year, (II) patient age, and (III) time after diagnosis. PATIENTS AND METHODS: US death certificate data in SEER Stat 8.2.1 were used to categorize cancer patient death as being due to index-cancer, non-index-cancer, and non-cancer cause from 1973 to 2012. In addition, data were characterized with standardized mortality ratios (SMRs), which provide the relative risk of death compared to all persons...
November 9, 2016: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/27823364/medical-management-of-spinal-epidural-empyema-in-five-dogs
#10
Susana R Monforte Monteiro, Antonella Gallucci, Nicolas Rousset, Paul M Freeman, Edward J Ives, Gualtiero Gandini, Nicolas Granger, An E Vanhaesebrouck
CASE DESCRIPTION 5 dogs were examined because of clinical signs of myelopathy, including signs of pain associated with the spinal region and rapidly progressive neurologic deficits. CLINICAL FINDINGS In all dogs, results of MRI were consistent with spinal epidural empyema. Concurrent infectious processes were identified at adjacent or distant sites in all dogs, including diskospondylitis, prostatitis, dermatitis, paraspinal infection following a penetrating injury, urinary tract infection, and pyothorax. Bacteria were isolated from 3 dogs; Escherichia coli was isolated from blood, urine, and prostatic wash samples from 1 dog; a Pasteurella sp was isolated from a percutaneous aspirate from an adjacent infected wound in a second dog; and a Corynebacterium sp was isolated from a thoracic fluid sample from a third dog...
November 15, 2016: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/27780014/clinical-presentations-and-epidemiology-of-urinary-tract-infections
#11
Suzanne E Geerlings
Urinary tract infection (UTI) is one of the most common bacterial infections, and the incidence in women is much higher than in men. The diagnosis of a UTI can be made based on a combination of symptoms and a positive urine analysis or culture. Most UTIs are uncomplicated UTIs, defined as cystitis in a woman who is not pregnant, is not immunocompromised, has no anatomical and functional abnormalities of the urogenital tract, and does not exhibit signs of tissue invasion and systemic infection. All UTIs that are not uncomplicated are considered to be complicated UTIs...
October 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27744176/robust-hplc-ms-ms-method-for-levofloxacin-and-ciprofloxacin-determination-in-human-prostate-tissue
#12
O Szerkus, J Jacyna, A Gibas, M Sieczkowski, D Siluk, M Matuszewski, R Kaliszan, M J Markuszewski
Fluoroquinolones are the drugs of choice in the prevention of bacterial infections after transrectal ultrasound guided prostate biopsy. In order to improve assessment of antibacterial efficacy in the target tissue a simple, selective, rapid and robust HPLC-ESI-MS/MS method for the determination of levofloxacin and ciprofloxacin concentrations in human prostate bioptates was developed and validated. Preparation procedure for prostate samples (10mg) was carried out using homogenization and filtration steps. Analyses were performed within 3...
January 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27742762/human-oral-microbiome-and-prospective-risk-for-pancreatic-cancer-a-population-based-nested-case-control-study
#13
Xiaozhou Fan, Alexander V Alekseyenko, Jing Wu, Brandilyn A Peters, Eric J Jacobs, Susan M Gapstur, Mark P Purdue, Christian C Abnet, Rachael Stolzenberg-Solomon, George Miller, Jacques Ravel, Richard B Hayes, Jiyoung Ahn
OBJECTIVE: A history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. We examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nested case-control study. DESIGN: We selected 361 incident adenocarcinoma of pancreas and 371 matched controls from two prospective cohort studies, the American Cancer Society Cancer Prevention Study II and the National Cancer Institute Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
October 14, 2016: Gut
https://www.readbyqxmd.com/read/27711089/serenoa-repens-associated-with-selenium-and-lycopene-extract-and-bromelain-and-methylsulfonylmethane-extract-are-able-to-improve-the-efficacy-of-levofloxacin-in-chronic-bacterial-prostatitis-patients
#14
RANDOMIZED CONTROLLED TRIAL
Tommaso Cai, Daniele Tiscione, Luca Gallelli, Paolo Verze, Alessandro Palmieri, Vincenzo Mirone, Riccardo Bartoletti, Gianni Malossini
OBJECTIVE: To date, the management of patients with chronic bacterial prostatitis (CBP) is not satisfactory, especially in terms of symptoms relief. Here, we evaluated the efficacy and the safety of a combination of serenoa repens, selenium and lycopene extract + bromelain and methylsulfonylmethane extract associated with levofloxacin in patients with CBP. MATERIALS AND METHODS: All patients with clinical and instrumental diagnosis of CBP, admitted to a single Urological Institution from March to June 2015 were enrolled in this phase III study...
October 5, 2016: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/27709861/risk-factor-analysis-of-ciprofloxacin-resistant-and-extended-spectrum-beta-lactamases-pathogen-induced-acute-bacterial-prostatitis-in-korea
#15
Young Lee, Dong Gi Lee, Sang Hyub Lee, Koo Han Yoo
The objectives of this study were to investigate risk factors and the incidence of ciprofloxacin resistance and extended-spectrum beta-lactamases (ESBL) in patients with acute bacterial prostatitis (ABP). We reviewed the medical records of 307 patients who were diagnosed with ABP between January 2006 and December 2015. The etiologic pathogens and risk factors for ciprofloxacin-resistant E. coli and ESBL-producing microbes, susceptibility to ciprofloxacin, and the incidence of ESBL in patients with ABP were described...
November 2016: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27698761/aminoglycoside-antibiotics-for-nih-category-ii-chronic-bacterial-prostatitis-a-single-cohort-study-with-one-year-follow-up
#16
Vittorio Magri, Emanuele Montanari, Emanuela Marras, Gianpaolo Perletti
Although fluoroquinolones are first-line agents for the treatment of National Institutes of Health (NIH) category II chronic bacterial prostatitis (CBP), therapy with these agents is not always feasible due to the increasing worldwide resistance of causative uropathogens. New therapeutic options are urgently required, as drugs such as β-lactam antibiotics distribute poorly to prostatic sites of infection and trimethoprim therapy is often unfeasible due to high resistance rates. The present study aimed to analyze the efficacy of aminoglycosides, administered to a cohort of 78 patients affected by fluoroquinolone-resistant CBP, or excluded from fluoroquinolone therapy due to various contraindications...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27659845/acute-and-subacute-toxicity-of-an-ethanolic-extract-of-melandrii-herba-in-crl-cd-sprague-dawley-rats-and-cytotoxicity-of-the-extract-in-vitro
#17
Eunsook Park, Mee-Young Lee, Chang-Seob Seo, Sae-Rom Yoo, Woo-Young Jeon, Hyeun-Kyoo Shin
BACKGROUND: Melandrii Herba, a medicinal plant, has been used in Korea for treatment of bacterial and fungal infection. However, the safety and toxicity of Melandrii Herba have not yet been established. Therefore, we investigated the acute and subacute toxicity of an ethanolic extract of Melandrii Herba (MHEE) in Crl:CD Sprague Dawley rats and cytotoxicity of MHEE in vitro. METHODS: To study acute toxicity, rats were treated with MHEE at single doses of 0, 500, 1000, and 2000 mg/kg administered by oral gavage, and body weight, clinical signs, and mortality were observed after dosing...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27600504/the-adherent-invasive-escherichia-coli-aiec-strain-lf82-invades-and-persists-in-human-prostate-cell-linerwpe-1-activating-a-strong-inflammatory-response
#18
Maria P Conte, Marta Aleandri, Massimiliano Marazzato, Antonietta L Conte, Cecilia Ambrosi, Mauro Nicoletti, Carlo Zagaglia, Guido Gambara, Fioretta Palombi, Paola De Cesaris, Elio Ziparo, Anna T Palamara, Anna Riccioli, Catia Longhi
Adherent/invasive Escherichia coli (AIEC) strains are recently receiving increased attention because they are more prevalent and persistent in the intestine of Crohn (CD) patients than in healthy subjects. Since AIEC strains show a high percentage of similarity with ExPEC NMEC and UPEC, here we compared AIEC strain LF82 with a UPEC isolate (strain EC73) to assess whether LF82 could be able to infect prostate cells, as an extra-intestinal target. The virulence phenotypes of both strains were determined by using the RWPE-1 prostate cell line...
September 6, 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27525394/-investigation-of-antitumorigenic-effects-of-food-borne-non-pathogenic-and-pathogenic-salmonella-enterica-strains-on-mef-du145-and-hela-cell-lines
#19
Gamze Altıntaş Kazar, Ece Şen
Basic applications in cancer therapy may fail to eradicate cancer cells completely, they can show toxic affects to healthy cells and development of resistance to antitumor agents may increase tendency to metastasis. Bacterial therapies have the advantage of specific targetting of tumors by selective toxicity, responsiveness to external signals, self-propelling capacity, and the sense of microenvironment. The most interest on the bacterial cancer therapy is about Salmonella spp. with a special emphasis of S...
July 2016: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/27506523/invasive-liver-abscess-syndrome-predisposed-by-klebsiella-pneumoniae-related-prostate-abscess-in-a-nondiabetic-patient-a-case-report
#20
Chen-Yi Liao, Ya-Sung Yang, Yen-Cheng Yeh, Ren-Jy Ben, Ching-Chang Lee, Chi-Chang Tsai, Chien-Yao Wang, Wu-Hsien Kuo, Chih-Chiang Wang
BACKGROUND: Prostate abscess is usually a complication of acute urinary tract infection. Invasive liver abscess syndrome is characterized with Klebsiella pneumoniae related multiple organ metastasis. Concomitant pyogenic liver abscess and prostate abscess have rarely been reported. Recurrent episode of liver abscess is even rarer. CASE PRESENTATION: We report a 71-year-old male with acute bacterial prostate abscess and urinary tract infection caused by K. pneumoniae associated with multiple liver abscess, psoas muscle abscess and osteomyelitis...
August 9, 2016: BMC Research Notes
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