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https://www.readbyqxmd.com/read/28228775/envenomation-by-the-red-tailed-coral-snake-micrurus-mipartitus-in-colombia
#1
Carlos A Cañas, Fernando Castro-Herrera, Santiago Castaño-Valencia
BACKGROUND: Although the red-tailed coral snake (Micrurus mipartitus) is widely distributed in Colombia and its venom is highly neurotoxic and life threatening, envenomation by this species is rare. Therefore, this report may shed some light on the clinical presentation of M. mipartitus bites. CASE PRESENTATIONS: Herein, we describe two cases of patients bitten by red-tailed coral snakes, illustrating the clinical presentation of the victims, the outcomes and treatment provided...
2017: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/28219972/venomics-integrative-venom-proteomics-and-beyond
#2
REVIEW
Juan J Calvete
Venoms are integrated phenotypes that evolved independently in, and are used for predatory and defensive purposes by, a wide phylogenetic range of organisms. The same principles that contribute to the evolutionary success of venoms, contribute to making the study of venoms of great interest in such diverse fields as evolutionary ecology and biotechnology. Evolution is profoundly contingent, and nature also reinvents itself continuosly. Changes in a complex phenotypic trait, such as venom, reflect the influences of prior evolutionary history, chance events, and selection...
February 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28216410/coagulopathy-and-extensive-local-swelling-following-green-pit-viper-trimeresurus-trigonocephalus-envenoming-in-sri-lanka
#3
R M M K Namal Rathnayaka, S A M Kularatne, P E A Nishanthi Ranathunga
Trimeresurus trigonocephalus (Sri Lankan Green pit viper) is a moderately venomous arboreal snake endemic to Sri Lanka. Even though, its bites are not uncommon, published reports of such cases are limited to three in literature. We report three cases of coagulopathy following Green pit viper bites and treatment with fresh frozen plasma.
February 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28216408/neuroprotective-property-of-low-molecular-weight-fraction-from-b-jararaca-snake-venom-in-h2o2-induced-cytotoxicity-in-cultured-hippocampal-cells
#4
Samyr Machado Querobino, Daniel Carneiro Carrettiero, Maricilia Silva Costa, Carlos Alberto-Silva
In central nervous system cells, low molecular weight fractions (LMWF) from snake venoms can inhibit changes in mitochondrial membrane permeability, preventing the diffusion of cytochrome c to the cytoplasm, inhibiting the activation of pro-apoptotic factors. Here, we evaluated the neuroprotective activity of LMWF from Bothrops jararaca (Bj) snake venom in H2O2-induced cytotoxicity in cultured hippocampal cells. SDS-PAGE, FT-IR and MALDI-TOF analysis of LMWF (<14 kDa) confirmed the absence of high-molecular-weight proteins in the fraction...
February 16, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28207897/correction-inhibitory-effects-of-hydroethanolic-leaf-extracts-of-kalanchoe-brasiliensis-and-kalanchoe-pinnata-crassulaceae-against-local-effects-induced-by-bothrops-jararaca-snake-venom
#5
Júlia Morais Fernandes, Juliana Félix-Silva, Lorena Medeiros da Cunha, Jacyra Antunes Dos Santos Gomes, Emerson Michell da Silva Siqueira, Luisa Possamai Gimenes, Norberto Peporine Lopes, Luiz Alberto Lira Soares, Matheus de Freitas Fernandes-Pedrosa, Silvana Maria Zucolotto
[This corrects the article DOI: 10.1371/journal.pone.0168658.].
2017: PloS One
https://www.readbyqxmd.com/read/28205610/cr-laao-an-l-amino-acid-oxidase-from-calloselasma-rhodostoma-venom-as-a-potential-tool-for-developing-novel-immunotherapeutic-strategies-against-cancer
#6
Tássia R Costa, Danilo L Menaldo, Karina F Zoccal, Sandra M Burin, Alexandre F Aissa, Fabíola A de Castro, Lúcia H Faccioli, Lusânia M Greggi Antunes, Suely V Sampaio
L-amino acid oxidases from snake venoms have been described to possess various biological functions. In this study, we investigated the inflammatory responses induced in vivo and in vitro by CR-LAAO, an L-amino acid oxidase isolated from Calloselasma rhodostoma venom, and its antitumor potential. CR-LAAO induced acute inflammatory responses in vivo, with recruitment of neutrophils and release of IL-6, IL-1β, LTB4 and PGE2. In vitro, IL-6 and IL-1β production by peritoneal macrophages stimulated with CR-LAAO was dependent of the activation of the Toll-like receptors TLR2 and TLR4...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205127/apoptosis-induced-by-a-snake-venom-metalloproteinase-from-bothrops-alternatus-venom-in-c2c12-muscle-cells
#7
Soledad Bustillo, Andrea C Van de Velde, Verónica Matzner Perfumo, Claudia C Gay, Laura C Leiva
In this study, the apoptosis inducing effects of baltergin as well as its influence on cell adhesion and migration on muscles cells in vitro were studied. Morphological analysis made by scanning electron and phase contrast microscopy demonstrated typical futures of programmed cell death, apoptosis. This mechanism was confirmed by fluorescence staining, molecular analysis of endonuclease activity and increased mRNA expression level of two representative genes (p53 and bax). On the other hand, baltergin exert an inhibition effect on myoblast cell adhesion and migration in vitro probably through a mechanism that involves the interaction of this enzyme with cell integrins...
February 15, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28185673/corrigendum-to-exploring-and-understanding-the-functional-role-and-biochemical-and-structural-characteristics-of-an-acidic-phospholipase-a2-apltx-i-purified-from-agkistrodon-piscivorus-leucostoma-snake-venom-toxicon-127-2017-22-36
#8
L M Resende, J R Almeida, R S Ramos, R C O Collaço, L R Simioni, D Ramírez, W González, A M Soares, L A Calderon, S Marangoni, S L da Silva
No abstract text is available yet for this article.
February 6, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28178774/a-retrospective-review-of-rattlesnake-bites-in-100-children
#9
Norberto Sotelo-Cruz, Norberto Gómez-Rivera
BACKGROUND: A retrospective review of clinical features and treatment of children hospitalized for rattlesnake bite. METHODS: One hundred clinical records were reviewed. Variables included: age, gender, season of the year, signs, symptoms, poisoning grade, complications, treatment and sequelae. RESULTS: Fifty-nine percent were males and 37% were less than 5 years of age; 87% occurred in rural areas; 63% of the snakebites occurred during the summer, of them, 39% occurred within the perimeter of the domicile and 8% within the home...
April 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28167587/snake-bite-induced-acute-kidney-injury-report-of-a-successful-outcome-during-pregnancy
#10
Sanjay Vikrant, Anupam Parashar
Snake bite is an important health hazard in tropics. Snake envenomation in pregnancy may cause fetal death and maternal mortality or morbidity. However, little is known about the toxic effects and optimal management during pregnancy after snake envenomation because of the rarity of cases. Herein, we report a case of a pregnant woman who was successfully treated for snake bite-induced acute kidney injury during the third trimester. She was treated with equine-derived polyvalent anti-snake venom without development of any adverse effects, hemodialysis, and supportive therapy...
February 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28163123/isolation-and-characterization-of-a-novel-metalloprotease-inhibitor-from-bothrops-alternatus-snake-serum
#11
Tatiana Z Palacio, Norival A Santos-Filho, José Cesar Rosa, Rui S Ferreira, Benedito Barraviera, Suely V Sampaio
Resistance of snakes and some other animals to snake envenomation has been attributed to soluble factors present in their tissues. Here we report the isolation of a novel metalloprotease inhibitor from Bothrops alternatus snake serum (named BaltMPI) with high purity, using a four-step chromatographic method. BaltMPI has molecular weights of 60.5 and 42.4kDa, as determined by SDS-PAGE and mass spectrometry, respectively, and pI=5.27. The first 60 amino acids from the N-terminal region of BaltMPI, determined by Edman's degradation, showed high homology (97%) with the snake venom metalloprotease inhibitor (SVMPI) BJ46a and other SVMPIs (78-82%)...
February 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28161122/acute-and-repeated-dose-28-days-toxicity-studies-in-rats-and-dogs-of-recombinant-batroxobin-a-snake-venom-thrombin-like-enzyme-expressed-from-pichia-pastoris
#12
Ok Hwan Kim, Kil-Sang Cho, Young Seomun, Jong-Tak Kim, Kwang-Hoe Chung
Recombinant batroxobin is a thrombin-like enzyme of Bothrops atrox moojeni venom. To evaluate its toxicological effect, it was highly expressed in Pichia pastorisand successfully purified to homogeneity from culture broth supernatant following Good Manufacturing Practice (GMP). The maximum tolerated dose of the recombinant batroxobin was examined in Sprague-Dawley (SD) rat and Beagle dogs following Good Laboratory Practice (GLP) regulations. The approximate lethal dose of recombinant batroxobin was 10 National Institute of Health (NIH) u/kg in male and female rats...
February 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28159722/cell-penetrating-and-cargo-delivery-ability-of-a-spider-toxin-derived-peptide-in-mammalian-cells
#13
Nisha Ponnappan, Archana Chugh
Cell-penetrating peptides are short cationic peptides with inherent ability to cross the plasma membrane barrier as well as intracellularly deliver cargo molecules conjugated to them. Venoms from snakes, scorpions and spiders are rich in membrane-active peptides. Crotamine from snake venom as well as maurocalcine and imperatoxin isolated from scorpion venoms have been reported to possess cell-penetrating property in mammalian cells. Latarcins, a group of spider venom toxins, has also been reported to possess antimicrobial property...
January 31, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28159706/venomics-of-naja-sputatrix-the-javan-spitting-cobra-a-short-neurotoxin-driven-venom-needing-improved-antivenom-neutralization
#14
Nget Hong Tan, Kin Ying Wong, Choo Hock Tan
: The venom proteome of Naja sputatrix (Javan spitting cobra) was elucidated through reverse-phase HPLC, nano-ESI-LCMS/MS and data mining. A total of 97 distinct protein forms belonging to 14 families were identified. The most abundant proteins are the three-finger toxins (3FTXs, 64.22%) and phospholipase A2 (PLA2, 31.24%), followed by nerve growth factors (1.82%), snake venom metalloproteinase (1.33%) and several proteins of lower abundance (<1%) including a variety of venom enzymes...
January 31, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28155167/inhibition-of-snake-venom-metalloproteinase-by-%C3%AE-lactoglobulin-peptide-from-buffalo-bubalus-bubalis-colostrum
#15
Ashok Arpitha, M Sebastin Santhosh, A C Rohit, K S Girish, D Vinod, H S Aparna
Bioactive peptide research has experienced considerable therapeutic interest owing to varied physiological functions, efficacy in excretion, and tolerability of peptides. Colostrum is a rich natural source of bioactive peptides with many properties elucidated such as anti-thrombotic, anti-hypertensive, opioid, immunomodulatory, etc. In this study, a variant peptide derived from β-lactoglobulin from buffalo colostrum was evaluated for the anti-ophidian property by targeting snake venom metalloproteinases. These are responsible for rapid local tissue damages that develop after snakebite such as edema, hemorrhage, myonecrosis, and extracellular matrix degradation...
February 2, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28150853/performance-of-the-20-minute-whole-blood-clotting-test-in-detecting-venom-induced-consumption-coagulopathy-from-russell-s-viper-daboia-russelii-bites
#16
Indira Ratnayake, Fathima Shihana, Dhammika M Dissanayake, Nicholas A Buckley, Kalana Maduwage, Geoffrey K Isbister
The 20-minute whole blood clotting test (WBCT20) is used as a bedside diagnostic test for coagulopathic snake envenoming. We aimed to assess the performance of the WBCT20 in diagnosis of venom induced consumption coagulopathy (VICC) in Russell's viper envenoming. Adult patients admitted with suspected snake bites were recruited from two hospitals. WBCT20 and prothrombin time (PT) test were performed on admission. WBCT20 was done by trained clinical research assistants using 1 ml whole blood in a 5 ml borosilicate glass tube with a 10 mm internal diameter...
February 2, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28149694/exploration-of-immunoglobulin-transcriptomes-from-mice-immunized-with-three-finger-toxins-and-phospholipases-a2-from-the-central-american-coral-snake-micrurus-nigrocinctus
#17
Andreas H Laustsen, Mikael Engmark, Christopher Clouser, Sonia Timberlake, Francois Vigneault, José María Gutiérrez, Bruno Lomonte
Snakebite envenomings represent a neglected public health issue in many parts of the rural tropical world. Animal-derived antivenoms have existed for more than a hundred years and are effective in neutralizing snake venom toxins when timely administered. However, the low immunogenicity of many small but potent snake venom toxins represents a challenge for obtaining a balanced immune response against the medically relevant components of the venom. Here, we employ high-throughput sequencing of the immunoglobulin (Ig) transcriptome of mice immunized with a three-finger toxin and a phospholipase A2 from the venom of the Central American coral snake, Micrurus nigrocinctus...
2017: PeerJ
https://www.readbyqxmd.com/read/28138054/bites-by-the-monocled-cobra-naja-kaouthia-in-chittagong-division-bangladesh-epidemiology-clinical-features-of-envenoming-and-management-of-70-identified-cases
#18
M A Faiz, M F Ahsan, A Ghose, M R Rahman, R Amin, M Hossain, M N Tareq, M A Jalil, U Kuch, R D G Theakston, D A Warrell, J B Harris
We describe 70 cases of monocled cobra (Naja kaouthia) bite admitted to Chittagong Medical College Hospital, Bangladesh. The biting snakes were identified by examining the dead snake and/or detecting N. kaouthia venom antigens in patients' serum. Bites were most common in the early morning and evening during the monsoon (May-July). Ligatures were routinely applied to the bitten limb before admission. Thirty-seven patients consulted traditional healers, most of whom made incisions around the bite site. Fifty-eight patients experienced severe neurotoxicity and most suffered swelling and pain of the bitten limb...
January 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28130154/what-killed-karl-patterson-schmidt-combined-venom-gland-transcriptomic-venomic-and-antivenomic-analysis-of-the-south-african-green-tree-snake-the-boomslang-dispholidus-typus
#19
Davinia Pla, Libia Sanz, Gareth Whiteley, Simon C Wagstaff, Robert A Harrison, Nicholas R Casewell, Juan J Calvete
BACKGROUND: Non-front-fanged colubroid snakes comprise about two-thirds of extant ophidian species. The medical significance of the majority of these snakes is unknown, but at least five species have caused life-threatening or fatal human envenomings. However, the venoms of only a small number of species have been explored. METHODS: A combined venomic and venom gland transcriptomic approach was employed to characterise of venom of Dispholidus typus (boomslang), the snake that caused the tragic death of Professor Karl Patterson Schmidt...
January 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28117768/induction-of-acute-skeletal-muscle-regeneration-by-cardiotoxin-injection
#20
Ombretta Guardiola, Gennaro Andolfi, Mario Tirone, Francescopaolo Iavarone, Silvia Brunelli, Gabriella Minchiotti
Skeletal muscle regeneration is a physiological process that occurs in adult skeletal muscles in response to injury or disease. Acute injury-induced skeletal muscle regeneration is a widely used, powerful model system to study the events involved in muscle regeneration as well as the mechanisms and different players. Indeed, a detailed knowledge of this process is essential for a better understanding of the pathological conditions that lead to skeletal muscle degeneration, and it aids in identifying new targeted therapeutic strategies...
January 1, 2017: Journal of Visualized Experiments: JoVE
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