keyword
MENU ▼
Read by QxMD icon Read
search

Snake venom

keyword
https://www.readbyqxmd.com/read/29656017/proteomic-and-toxinological-characterization-of-the-venom-of-the-south-african-ringhals-cobra-hemachatus-haemachatus
#1
Andrés Sánchez, María Herrera, Mauren Villalta, Daniela Solano, Álvaro Segura, Bruno Lomonte, José María Gutiérrez, Guillermo León, Mariángela Vargas
The protein composition and toxinological profile of the venom of the African spitting elapid Hemachatus haemachatus (Ringhals) were characterized by bottom-up proteomics and functional in vitro and in vivo assays. Venom is composed of abundant three-finger toxins (3FTxs; 63.3%), followed by phospholipases A2 (PLA2 s; 22.8%), snake venom metalloproteinases (SVMPs 7.1%), cysteine-rich secretory proteins (CRISPs; 4.1%) and Kunitz type protease inhibitors (KTPIs; 1.5%). 3FTxs are the main responsible for lethality and myotoxicity in mice and in vitro anticoagulant activity...
April 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29651298/true-or-false-coral-snake-is-it-worth-the-risk-a-micrurus-corallinus-case-report
#2
Marcelo Abrahão Strauch, Guilherme Jones Souza, Jordana Nahar Pereira, Tyelli Dos Santos Ramos, Marcelo Oliveira Cesar, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Fernando Chagas Patrão-Neto, Paulo A Melo
Background: Bites provoked by the genus Micrurus represent less than 1% of snakebite cases notified in Brazil, a tiny fraction compared with other genus such as Bothrops and Crotalus , which together represent almost 80% of accidents. In addition to their less aggressive behavior, habits and morphology of coral snakes are determinant factors for such low incidence of accidents. Although Micrurus bites are rare, victims must be rescued and hospitalized in a short period of time, because this type of envenoming may evolve to a progressive muscle weakness and acute respiratory failure...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
https://www.readbyqxmd.com/read/29629287/infrequent-use-of-medicinal-plants-from-india-in-snakebite-treatment
#3
REVIEW
Manali Sughosh Upasani, Sughosh Vishweshwar Upasani, Vishal Gokul Beldar, Chetana Gokul Beldar, Pranjal P Gujarathi
Snakes have fascinated humankind for millennia. Snakebites are a serious medical, social, and economic problem that are experienced worldwide; however, they are most serious in tropical and subtropical countries. The reasons for this are 1) the presence of more species of the most dangerous snakes, 2) the inaccessibility of immediate medical treatment, and 3) poor health care. The goal of this study was to collect information concerning rare, less utilized, and less studied medicinal plants. More than 100 plants were found to have potential to be utilized as anti-snake venom across India...
March 2018: Integrative Medicine Research
https://www.readbyqxmd.com/read/29626299/short-chain-consensus-alpha-neurotoxin-a-synthetic-60-mer-peptide-with-generic-traits-and-enhanced-immunogenic-properties
#4
Guillermo de la Rosa, Ligia L Corrales-García, Ximena Rodriguez-Ruiz, Estuardo López-Vera, Gerardo Corzo
The three-fingered toxin family and more precisely short-chain α-neurotoxins (also known as Type I α-neurotoxins) are crucial in defining the elapid envenomation process, but paradoxically, they are barely neutralized by current elapid snake antivenoms. This work has been focused on the primary structural identity among Type I neurotoxins in order to create a consensus short-chain α-neurotoxin with conserved characteristics. A multiple sequence alignment considering the twelve most toxic short-chain α-neurotoxins reported from the venoms of the elapid genera Acanthophis, Oxyuranus, Walterinnesia, Naja, Dendroaspis and Micrurus led us to propose a short-chain consensus α-neurotoxin, here named ScNtx...
April 6, 2018: Amino Acids
https://www.readbyqxmd.com/read/29626137/snakebites-in-africa-and-europe-a-military-perspective-and-update-for-contemporary-operations
#5
REVIEW
Daniel Wilkins, D S Burns, D Wilson, D A Warrell, L E M Lamb
Snakebite envenoming is rare among military patients, with few cases reported in recent years. Increasingly, however, military operations are taking place in remote parts of Africa, which are inhabited by numerous species of venomous snake, and in Europe, where dangerous species exist but are less common. Bites from a venomous snake may prove fatal, and therefore military medics must be adequately prepared to manage them. This paper reviews the most medically significant species of venomous snake present in Africa and Europe, before suggesting an evidence-based approach to snakebite prevention and management, including possible changes to the UK's Clinical Guidelines for Operations...
April 5, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29625942/lethal-toxic-dose-i-p-ld50-total-protein-contents-and-comparative-hemolytic-potential-of-99mtc-labeled-non-labeled-naja-naja-karachiensis-venom
#6
Muhammad Hassham Bin Asad, Arooj Fatima Asad, Sumbal Bibi, Kaleem Ullah, Tariq Javed, Majeed Ullah, Atif Ali, Ziaur Rahman Qureshi, Muhammad Imran Amirzada, Yasser Msa Al-Kahraman, Syed Muhammad Farid Hasan, Jean-Marc Sabatier, Albert Rizvanov
Recent recognition about snake bite envenomation on June, 2017 as neglected tropical disease under category-A by World Health Organization advocated again its undeniable importance. Present circumstances reasoned to work on a neglected subspecies of Naja naja, i.e., Naja naja karachiensis (N. n. karachensis) has been documented for frequent deaths in Pakistan. In this study median lethal toxic dose (LD50 ) was determined intraperitoneally in Swiss albino mice and was found to be 2.0µg/g (2.0mg/kg) equal in potency to Naja pallida (red spitting African cobra)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29621647/molecular-mechanisms-underlying-intraspecific-variation-in-snake-venom
#7
Diana R Amazonas, José A Portes-Junior, Milton Y Nishiyama-Jr, Carolina A Nicolau, Hipócrates M Chalkidis, Rosa H V Mourão, Felipe G Grazziotin, Darin R Rokyta, H Lisle Gibbs, Richard H Valente, Inácio L M Junqueira-de-Azevedo, Ana M Moura-da-Silva
Elucidating the molecular mechanisms underlying snake venom variability provides important clues for understanding how the biological functions of this powerful toxic arsenal evolve. We analyzed in detail individual transcripts and venom protein isoforms produced by five specimens of a venomous snake (Bothrops atrox) from two nearby but genetically distinct populations from the Brazilian Amazon rainforest which show functional similarities in venom properties. Individual variation was observed among the venoms of these specimens, but the overall abundance of each general toxin family was conserved both in transcript and in venom protein levels...
April 2, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29621528/what-can-be-learned-in-the-snake-antivenom-field-from-the-developments-in-human-plasma-derived-products
#8
Thierry Burnouf
Human plasma-derived medicinal products and snake antivenom immunoglobulins are unique and complex therapeutic protein products. Human plasma products are obtained by fractionating large pools of plasma collected from blood plasma donors. They comprise a wide range of protein products, including polyvalent and hyperimmune immunoglobulins, coagulation factors, albumin, and various protease inhibitors that are transfused to patients affected by congenital or acquired protein deficiencies, immunological disorders, or metabolic diseases...
April 2, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29617989/knowledge-of-venomous-snakes-snakebite-first-aid-treatment-and-prevention-among-clinicians-in-northern-nigeria-a-cross-sectional-multicentre-study
#9
Godpower C Michael, Bukar A Grema, Ibrahim Aliyu, Mohammed A Alhaji, Teslim O Lawal, Haliru Ibrahim, Aminu G Fikin, Fatima S Gyaran, Kennedy N Kane, Thomas D Thacher, Abba K Badamasi, Emmanuel Ogwuche
Background: Snakebite envenoming causes considerable morbidity and mortality in northern Nigeria. The clinician's knowledge of snakebite impacts outcome. We assessed clinicians' knowledge of snakebite envenoming to highlight knowledge and practice gaps for possible intervention to improve snakebite outcomes. Methods: This was a cross-sectional multicentre study of 374 doctors selected from the accident and emergency, internal medicine, family medicine/general outpatient, paediatrics and surgery departments of nine tertiary hospitals in northern Nigeria using a multistage sampling technique...
March 29, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29616641/snake-bites-by-bothrops-lanceolatus-in-martinique
#10
D Resiere, M Hossein, B Megarbane
Bothrops lanceolatus, a member of the Viperidae family and Crotalinae subfamily, is the only snake causing envenomation in Martinique, which is the only place it exists in the world. Any bite by this snake may result in severe thrombotic complications including cerebral, pulmonary, and myocardial infarction and affecting the patient's vital or functional prognosis. The exact composition of the venom as well as the mechanisms of toxicity involved are still debated today. The first specific antivenom immunotherapy (AVI), Bothrofav1, manufactured in 1991, reduced mortality and morbidity significantly...
February 1, 2018: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29615942/association-between-fear-and-beauty-evaluation-of-snakes-cross-cultural-findings
#11
Eva Landová, Natavan Bakhshaliyeva, Markéta Janovcová, Šárka Peléšková, Mesma Suleymanova, Jakub Polák, Akif Guliev, Daniel Frynta
According to the fear module theory, humans are evolutionarily predisposed to perceive snakes as prioritized stimuli and exhibit a fast emotional and behavioral response toward them. In Europe, highly dangerous snake species are distributed almost exclusively in the Mediterranean and Caspian areas. While the risk of a snakebite is relatively low in Central Europe, Azerbaijan, on the other hand, has a high occurrence of the deadly venomous Levant viper ( Macrovipera lebetina ). We hypothesize that co-habitation with this dangerous snake has shaped the way in which humans evaluate snake species resembling it...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29611503/accuracy-of-the-lee-white-clotting-time-performed-in-the-hospital-routine-to-detect-coagulopathy-in-bothrops-atrox-envenomation
#12
Jose Diego de Brito Sousa, Jacqueline Almeida Gonçalves Sachett, Sâmella Santos Oliveira, Iran Mendonça-da-Silva, Hedylamar Oliveira Marques, Marcus Vinicius Guimarães de Lacerda, Hui Wen Fan, Wuelton Marcelo Monteiro
Snake envenomation is a major public health problem in Brazil. Systemic complications that may arise from snakebites are mainly related to coagulopathy. The Lee-White clotting time (LWCT) is a simple and inexpensive test and available even in remote health facilities. However, the diagnostic value of such test needs to be evaluated to accurately diagnose coagulopathy in the clinical practice. This study aimed to assess the reliability of the LWCT performed in hospital routine to diagnose venom-induced coagulopathy...
April 2, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29611136/cytotoxicity-of-silica-nanoparticles-with-transcaucasian-nose-horned-viper-vipera-ammodytes-transcaucasiana-venom-on-u87mg-and-shsy5y-neuronal-cancer-cells
#13
Çiğdem Çelen, Ceren Keçeciler, Mert Karış, Bayram Göçmen, Ozlem Yesil-Celiktas, Ayşe Nalbantsoy
Highly bioactive compounds of the snake venom make them particular sources for anticancer agent development. They contain very rich peptide-protein structures. Therefore, they are very susceptible to environmental conditions such as temperature, pH, and light. In this study, Vipera ammodytes transcaucasiana venom was encapsulated in PAMAM-G4 dendrimer by sol-gel method in order to prevent degradation of venom contents from the environmental conditions. For this purpose, nanoparticles were prepared by sol-gel methodology and SEM analyses were performed...
April 3, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29608922/conservation-analysis-and-decomposition-of-residue-correlation-networks-in-the-phospholipase-a2-superfamily-pla2s-insights-into-the-structure-function-relationships-of-snake-venom-toxins
#14
Alberto Oliveira, Lucas Bleicher, Carlos G Schrago, Floriano Paes Silva Junior
Phospholipases A2 (PLA2 s) comprise a superfamily of glycerophospholipids hydrolyzing enzymes present in many organisms in nature, whose catalytic activity was majorly unveiled by analysis of snake venoms. The latter have pharmaceutical and biotechnological interests and can be divided into different functional sub-classes. Our goal was to identify important residues and their relation to the functional and class-specific characteristics in the PLA2 s family with special emphasis on snake venom PLA2 s (svPLA2 s)...
March 30, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29604435/in-vitro-effects-of-crotalus-atrox-snake-venom-on-chick-and-mouse-neuromuscular-preparations
#15
Raphael Schezaro-Ramos, Saulo L Da Silva, Beatriz B Pereira, Ananda T Santa Fé Miguel, Bruno Mendes, Noroska G S Mogollón, Stephen Hyslop, Victor C Carregari, José R Almeida
The neuromuscular effect of rattlesnake venoms is not a major clinical manifestation shared between rattlesnakes native to the Americas, which showed two different venom phenotypes. Taking into account this dichotomy, nerve muscle preparations from mouse and chicks were used to investigate the ability of Crotalus atrox venom to induce in vitro neurotoxicity and myotoxicity. Unlike crotalic venoms of South America, low doses of C. atrox venom did not result in significant effects on mouse neuromuscular preparations...
March 28, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29604354/thrombin-like-enzymes-from-snake-venom-structural-characterization-and-mechanism-of-action
#16
REVIEW
Anwar Ullah, Rehana Masood, Ijaz Ali, Kifayat Ullah, Hamid Ali, Haji Akbar, Christian Betzel
Snake venom thrombin-like enzymes (SVTLEs) constitute the major portion (10-24%) of snake venom and these are the second most abundant enzymes present in the crude venom. During envenomation, these enzymes had shown prominently the various pathological effects, such as disturbance in hemostatic system, fibrinogenolysis, fibrinolysis, platelet aggregation, thrombosis, neurologic disorders, activation of coagulation factors, coagulant, procoagulant etc. These enzymes also been used as a therapeutic agent for the treatment of various diseases such as congestive heart failure, ischemic stroke, thrombotic disorders etc...
March 28, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29595048/the-cobra-effect-a-venomous-snake-in-the-neurosurgical-field
#17
Marco Fontanella
No abstract text is available yet for this article.
March 28, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29594003/snake-bite-in-third-trimester-of-pregnancy-with-systemic-envenomation-and-delivery-of-a-live-baby-in-a-low-resource-setting-a-case-report
#18
Adebayo A Adewole, Osadolor A Ugiagbe, Temitope G Onile, Gabriel A Joseph, Oluwamayowa D Kassim, Patricia F Medupin, Abiodun S Adeniran
Background: Snake bite in the third trimester of pregnancy with late presentation, systemic envenomation; disseminated intravascular coagulopathy and delivery of a live neonate is uncommon in a low resource setting. Case: We present a 22 year old unbooked Gravida 3 Para 1+ 1 1alive lentiviral positive woman at 32 weeks gestation with snake bite, leg swelling, vaginal bleeding and labour pains. At presentation, there were anemia, tachycardia, hypotension; a gravid uterus with a single fetus in longitudinal lie, cephalic presentation, regular fetal heart rate and cervical dilatation of 3 cm...
October 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29589526/adam-metalloproteinases-as-potential-drug-targets
#19
Caterina Camodeca, Doretta Cuffaro, Elisa Nuti, Armando Rossello
The ADAMs, together with ADAMTSs and snake venom metalloproteases (SVMPs), are members of the Adamalysin family. Differences in structural organization, functions and localization are known and their domains, catalytic or non-catalytic, show key roles in the substrate recognition and protease activity. Some ADAMs, as membrane-bound enzymes, show sheddase activity. Sheddases are key to modulation of functional proteins such as the tumor necrosis factor, growth factors, cytokines and their receptors, adhesion proteins, signaling molecules and stress molecules involved in immunity...
March 26, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29574214/mechanistic-insights-into-functional-characteristics-of-native-crotamine
#20
Daniel Batista da Cunha, Ana Vitória Pupo Silvestrini, Ana Carolina Gomes da Silva, Deborah Maria de Paula Estevam, Flávia Lino Pollettini, Juliana de Oliveira Navarro, Armindo Antônio Alves, Ana Laura Remédio Zeni Beretta, Joyce M Annichino Bizzacchi, Lilian Cristina Pereira, Maurício Ventura Mazzi
The chemical composition of snake venoms is a complex mixture of proteins and peptides that can be pharmacologically active. Crotamine, a cell-penetrating peptide, has been described to have antimicrobial properties and it exerts its effects by interacting selectively with different structures, inducing changes in the ion flow pattern and cellular responses. However, its real therapeutic potential is not yet fully known. Bearing in mind that crotamine is a promising molecule in therapeutics, this study investigated the action of purified molecule in three aspects: I) antibacterial action on different species of clinical interest, II) the effect of two different concentrations of the molecule on platelet aggregation, and III) its effects on isolated mitochondria...
March 21, 2018: Toxicon: Official Journal of the International Society on Toxinology
keyword
keyword
112206
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"