Alejandro Suarez-Pierre, Cecillia Lui, Xun Zhou, Sean Kearney, Melissa Jones, Jie Wang, Rosmi P Thomas, Natalie Gaughan, Thomas S Metkus, Mary B Brady, Brian C Cho, Jeffrey M Dodd-O, Jennifer S Lawton
OBJECTIVE: Adenosine triphosphate potassium sensitive channels provide endogenous myocardial protection via coupling of cell membrane potential to myocardial metabolism. Adenosine triphosphate potassium sensitive channel openers, such as diazoxide, mimic ischemic preconditioning, prevent cardiomyocyte swelling, preserve myocyte contractility after stress, and provide diastolic protection. We hypothesize that diazoxide combined with hyperkalemic cardioplegia provides superior myocardial protection compared with cardioplegia alone during prolonged global ischemia in a large animal model...
August 26, 2020: Journal of Thoracic and Cardiovascular Surgery