Haiyang Jiang, Peizhao Liu, Jiaqi Kang, Jie Wu, Wenbin Gong, Xuanheng Li, Yangguang Li, Juanhan Liu, Weizhen Li, Chujun Ni, Bo Liao, Xiuwen Wu, Yun Zhao, Jianan Ren
Gasdermins (GSDMs) serve as pivotal executors of pyroptosis and play crucial roles in host defence, cytokine secretion, innate immunity, and cancer. However, excessive or inappropriate GSDMs activation is invariably accompanied by exaggerated inflammation and results in tissue damage. In contrast, deficient or impaired activation of GSDMs often fails to promptly eliminate pathogens, leading to the increasing severity of infections. The activity of GSDMs requires meticulous regulation. The dynamic modulation of GSDMs involves many aspects, including autoinhibitory structures, proteolytic cleavage, lipid binding and membrane translocation (oligomerization and pre-pore formation), oligomerization (pore formation) and pore removal for membrane repair...
2023: International Journal of Biological Sciences