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Metformin and cardioprotection

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https://www.readbyqxmd.com/read/27788262/resveratrol-reverses-functional-chagas-heart-disease-in-mice
#1
Glaucia Vilar-Pereira, Vitor C Carneiro, Hilton Mata-Santos, Amanda R R Vicentino, Isalira P Ramos, Naira L L Giarola, Daniel F Feijó, José R Meyer-Fernandes, Heitor A Paula-Neto, Emiliano Medei, Marcelo T Bozza, Joseli Lannes-Vieira, Claudia N Paiva
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of parasite burden. During disease, the heart undergoes oxidative stress, a potential causative factor for arrhythmias and contractile dysfunction. Here we tested whether antioxidants/ cardioprotective drugs could improve cardiac function in established Chagas heart disease. We chose a model that resembles B1-B2 stage of human CCC, treated mice with resveratrol and performed electrocardiography and echocardiography studies...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27687032/impact-of-bromocriptine-qr-therapy-on-cardiovascular-outcomes-in-type-2-diabetes-mellitus-subjects-on-metformin
#2
Bindu Chamarthi, Michael Ezrokhi, Dean Rutty, Anthony H Cincotta
OBJECTIVES: Type 2 diabetes mellitus (T2DM) is associated with a substantially increased risk of cardiovascular disease (CVD). Bromocriptine-QR (B-QR), a quick release sympatholytic dopamine D2 receptor agonist, is a FDA-approved therapy for T2DM which may provide CVD risk reduction. Metformin is considered to be an agent with a potential cardioprotective benefit. This large placebo controlled clinical study assessed the impact of B-QR addition to existing metformin therapy on CVD outcomes in T2DM subjects...
November 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27669556/metformin-synergizes-with-conventional-and-adjuvant-analgesic-drugs-to-reduce-inflammatory-hyperalgesia-in-rats
#3
Uroš B Pecikoza, Maja A Tomić, Ana M Micov, Radica M Stepanović-Petrović
BACKGROUND: Metformin is a widely used and safe antidiabetic drug that has recently been shown to possess analgesic properties in models of inflammatory pain. Because various arthritic inflammatory disorders are highly prevalent in diabetic patients, we aimed to examine the type of interaction between metformin and several conventional and adjuvant analgesic drugs (ibuprofen, aspirin, tramadol, and pregabalin) in a rat model of somatic inflammatory hyperalgesia. METHODS: Inflammation of the rat hind paw was induced by an intraplantar injection of carrageenan (0...
September 23, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27621180/metformin-protects-against-infection-induced-myocardial-dysfunction
#4
Theodora Tzanavari, Aimilia Varela, Stamatis Theocharis, Elpinickie Ninou, Alkistis Kapelouzou, Dennis V Cokkinos, Maria I Kontaridis, Katia P Karalis
BACKGROUND AND PURPOSE: Metformin administration is associated with myocardial protection during ischemia and/or reperfusion, possibly via inhibition of inflammatory responses in the heart. Exposure to pathogens, in addition to the activation of the immune system and the associated metabolic dysfunction, often results in compromised myocardial function. We examined whether metformin administration could maintain the normal myocardial function in experimental moderate Gram negative infection, induced by lipopolysaccharide (LPS) administration...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27561827/metformin-improves-circulating-endothelial-cells-and-endothelial-progenitor-cells-in-type-1-diabetes-merit-study
#5
Fahad W Ahmed, Rachel Rider, Michael Glanville, Kilimangalam Narayanan, Salman Razvi, Jolanta U Weaver
BACKGROUND: Type 1 diabetes is associated with increased cardiovascular disease (CVD). Decreased endothelial progenitor cells (EPCs) number plays a pivotal role in reduced endothelial repair and development of CVD. We aimed to determine if cardioprotective effect of metformin is mediated by increasing circulating endothelial progenitor cells (cEPCs), pro-angiogenic cells (PACs) and decreasing circulating endothelial cells (cECs) count whilst maintaining unchanged glycemic control. METHODS: This study was an open label and parallel standard treatment study...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27465053/phosphodiesterase-type-5-inhibitor-use-in-type-2-diabetes-is-associated-with-a-reduction-in-all-cause-mortality
#6
Simon G Anderson, David C Hutchings, Mark Woodward, Kazem Rahimi, Martin K Rutter, Mike Kirby, Geoff Hackett, Andrew W Trafford, Adrian H Heald
OBJECTIVE: Experimental evidence has shown potential cardioprotective actions of phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in patients with type 2 diabetes, with high-attendant cardiovascular risk, was associated with altered mortality in a retrospective cohort study. RESEARCH DESIGN AND METHODS: Between January 2007 and May 2015, 5956 men aged 40-89 years diagnosed with type 2 diabetes before 2007 were identified from anonymised electronic health records of 42 general practices in Cheshire, UK, and were followed for 7...
November 1, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27326818/estrogen-and-dpp4-inhibitor-but-not-metformin-exert-cardioprotection-via-attenuating-cardiac-mitochondrial-dysfunction-in-obese-insulin-resistant-and-estrogen-deprived-female-rats
#7
Sivaporn Sivasinprasasn, Piangkwan Sa-Nguanmoo, Wanpitak Pongkan, Wasana Pratchayasakul, Siriporn C Chattipakorn, Nipon Chattipakorn
OBJECTIVE: Cardiac function was markedly compromised in obese insulin-resistant and estrogen-deprived rats. Metformin and dipeptidyl peptidase-4 inhibitor (vildagliptin) were reported to improve cardiac function in insulin-resistant rats. Their effects on the heart under estrogen-deprived conditions are, however, unknown. Therefore, the effects of metformin, vildagliptin, and estrogen on the cardiac function in estrogen-deprived insulin-resistant female rats were investigated. METHODS: Bilateral ovariectomized female rats (n = 48) were divided to be fed with either a normal diet (ND) or a high-fat diet (HFD) for 12 weeks...
August 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27294149/metformin-protects-h9c2-cardiomyocytes-from-high-glucose-and-hypoxia-reoxygenation-injury-via-inhibition-of-reactive-oxygen-species-generation-and-inflammatory-responses-role-of-ampk-and-jnk
#8
Mingyan Hu, Ping Ye, Hua Liao, Manhua Chen, Feiyan Yang
Metformin is a first-line drug for the management of type 2 diabetes. Recent studies suggested cardioprotective effects of metformin against ischemia/reperfusion injury. However, it remains elusive whether metformin provides direct protection against hypoxia/reoxygenation (H/R) injury in cardiomyocytes under normal or hyperglycemic conditions. This study in H9C2 rat cardiomyoblasts was designed to determine cell viability under H/R and high-glucose (HG, 33 mM) conditions and the effects of cotreatment with various concentrations of metformin (0, 1, 5, and 10 mM)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27111198/cardioprotective-effect-of-metformin-against-doxorubicin-cardiotoxicity-in-rats
#9
EDITORIAL
Yi-Tang Tseng
No abstract text is available yet for this article.
April 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27069466/fenofibrate-plus-metformin-produces-cardioprotection-in-a-type-2-diabetes-and-acute-myocardial-infarction-model
#10
Víctor Hugo Oidor-Chan, Enrique Hong, Francisca Pérez-Severiano, Sergio Montes, Juan Carlos Torres-Narváez, Leonardo Del Valle-Mondragón, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza
We investigated whether fenofibrate, metformin, and their combination generate cardioprotection in a rat model of type 2 diabetes (T2D) and acute myocardial infarction (AMI). Streptozotocin-induced diabetic- (DB-) rats received 14 days of either vehicle, fenofibrate, metformin, or their combination and immediately after underwent myocardial ischemia/reperfusion (I/R). Fenofibrate plus metformin generated cardioprotection in a DBI/R model, reported as decreased coronary vascular resistance, compared to DBI/R-Vehicle, smaller infarct size, and increased cardiac work...
2016: PPAR Research
https://www.readbyqxmd.com/read/27044778/effects-of-dipeptidyl-peptidase-4-inhibitor-in-insulin-resistant-rats-with-myocardial-infarction
#11
Nattayaporn Apaijai, Tharnwimol Inthachai, Suree Lekawanvijit, Siriporn C Chattipakorn, Nipon Chattipakorn
Adverse cardiac remodeling after myocardial infarction (MI) leads to progressive heart failure. Obese-insulin resistance increases risks of MI and heart failure. Although dipeptidyl peptidase-4 (DPP4) inhibitor is known to exert cardioprotection, its effects on adverse remodeling after MI in obese-insulin-resistant rats are unclear. We hypothesized that DPP4 inhibitor reduces adverse left ventricular (LV) remodeling and LV dysfunction in obese-insulin-resistant rats with MI. Rats were fed either normal diet (ND) or high-fat diet (HFD) for 12 weeks to induce obese-insulin resistance, followed by left anterior descending coronary artery ligation to induce MI...
June 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27042415/effects-of-gliclazide-add-on-metformin-on-serum-omentin-1-levels-in-patients-with-type-2-diabetes-mellitus
#12
Ali I Al-Gareeb, Haidar F Alrubai, Sammar M Suliaman
BACKGROUND: Omentin is a newly identified adipokine that has beneficial influence against cardiovascular disorders. Hence, considering the impact of anti-diabetic drug on omentin levels may provide an adjuvant strategy to protect diabetic patients against valuable clinical hazards. AIM OF THE STUDY: To investigate the influence of metformin alone or in combination with gliclazide on the level of serum omentin among patients with type 2 diabetes mellitus (T2DM). PATIENTS AND METHODS: A total of 70 newly diagnosed patients with T2DM were enrolled in this randomized, double-blind prospective study, and divided into two equal groups based on treatment regimen in which Group 1 treated with metformin (1000 mg) and Group 2 treated with metformin (1000 mg) plus gliclazide (80 mg)...
March 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26963617/effects-of-metformin-on-tissue-oxidative-and-dicarbonyl-stress-in-transgenic-spontaneously-hypertensive-rats-expressing-human-c-reactive-protein
#13
Hana Malínská, Olena Oliyarnyk, Vojtěch Škop, Jan Šilhavý, Vladimír Landa, Václav Zídek, Petr Mlejnek, Miroslava Šimáková, Hynek Strnad, Ludmila Kazdová, Michal Pravenec
Inflammation and oxidative and dicarbonyl stress play important roles in the pathogenesis of type 2 diabetes. Metformin is the first-line drug of choice for the treatment of type 2 diabetes because it effectively suppresses gluconeogenesis in the liver. However, its "pleiotropic" effects remain controversial. In the current study, we tested the effects of metformin on inflammation, oxidative and dicarbonyl stress in an animal model of inflammation and metabolic syndrome, using spontaneously hypertensive rats that transgenically express human C-reactive protein (SHR-CRP)...
2016: PloS One
https://www.readbyqxmd.com/read/26861446/metformin-improves-the-angiogenic-potential-of-human-cd34%C3%A2-%C2%BA-cells-co-incident-with-downregulating-cxcl10-and-timp1-gene-expression-and-increasing-vegfa-under-hyperglycemia-and-hypoxia-within-a-therapeutic-window-for-myocardial-infarction
#14
Sherin Bakhashab, Fahad W Ahmed, Hans-Juergen Schulten, Ayat Bashir, Sajjad Karim, Abdulrahman L Al-Malki, Mamdooh A Gari, Adel M Abuzenadah, Adeel G Chaudhary, Mohammed H Alqahtani, Sahira Lary, Farid Ahmed, Jolanta U Weaver
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify the most effective treatment for CVD, it is paramount to understand the mechanism behind cardioprotective therapies. Although metformin has been shown to reduce CVD in Type-2 DM clinical trials, the underlying mechanism remains unexplored. CD34(+) cell-based therapies offer a new treatment approach to CVD. The aim of this study was to investigate the effect of metformin on the angiogenic properties of CD34(+) cells under conditions mimicking acute myocardial infarction in diabetes...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/26722031/effects-of-administered-cardioprotective-drugs-on-treatment-response-of-breast-cancer-cells
#15
Tim A D Smith, Su M Phyu, Emmanuel U Akabuogu
BACKGROUND: Anticancer drug treatment, particularly with anthracyclines, is frequently associated with cardiotoxicity, an effect exacerbated by trastuzumab. Several compounds are in use clinically to attenuate the cardiac-damaging effects of chemotherapy drugs, including angiotensin-converting enzyme (ACE) inhibitors, beta-blockers, the anti-diabetic drug metformin, and dexrazoxane. However, there is concern that the cardiac-preserving mechanisms of these drugs may also limit the anticancer efficacy of the chemotherapeutic agents...
January 2016: Anticancer Research
https://www.readbyqxmd.com/read/26708162/cardioprotective-effect-of-metformin-in-lipopolysaccharide-induced-sepsis-via-suppression-of-toll-like-receptor-4-tlr4-in-heart
#16
Haleh Vaez, Maryam Rameshrad, Moslem Najafi, Jaleh Barar, Abolfazl Barzegari, Alireza Garjani
Sepsis-induced myocardial dysfunction is a serious organ complication. In the present study, we investigated the effect of metformin on myocardial dysfunction and TLR4 activity in LPS-induced sepsis. Male Wistar rats were randomly divided into 3 groups (n=6): control received normal saline (0.5ml), LPS group received lipopolysaccharide (0.5mg/kg; i.p), and metformin treated group received LPS (0.5mg/kg)+metformin (100mg/kg; i.p). 9h later the hemodynamic parameters were recorded, blood samples were collected, and the hearts were removed and weighted...
February 5, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/26642465/cardioprotective-effect-of-metformin-against-doxorubicin-cardiotoxicity-in-rats
#17
Mustafa Argun, Kazım Üzüm, Mehmet Fatih Sönmez, Abdullah Özyurt, Karabulut Derya, Kübra Tuğçe Çilenk, Sunay Unalmış, Özge Pamukcu, Ali Baykan, Figen Narin, Ferhan Elmalı, Nazmi Narin
OBJECTIVE: The clinical use of doxorubicin, which is a strong antineoplastic agent, is limited due to its cardiotoxic side effects. Metformin is a drug with antihyperglycemic effects, and it has been shown to have a cardioprotective effect on left ventricular function in experimental animal models of myocardial ischemia. The present study investigated the cardioprotective effect of metformin in rats with doxorubicin cardiotoxicity. METHODS: Wistar albino rats were used in the study...
April 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/26494519/metformin-and-myocardial-injury-in-patients-with-diabetes-and-st-segment-elevation-myocardial-infarction-a-propensity-score-matched-analysis
#18
Suresh Basnet, Andrzej Kozikowski, Amgad N Makaryus, Renee Pekmezaris, Roman Zeltser, Meredith Akerman, Martin Lesser, Gisele Wolf-Klein
BACKGROUND: Although animal studies have documented metformin's cardioprotective effects, the impact in humans remains elusive. The study objective was to explore the association between metformin and myocardial infarct size in patients with diabetes presenting with ST-segment elevation myocardial infarction. METHODS AND RESULTS: Data extraction used the National Cardiovascular Data CathPCI Registry in all patients with diabetes aged >18 years presenting with ST-segment elevation myocardial infarction at 2 academic medical centers from January 2010 to December 2013...
October 2015: Journal of the American Heart Association
https://www.readbyqxmd.com/read/26284918/a-comparison-of-the-effects-of-the-glp-1-analogue-liraglutide-and-insulin-glargine-on-endothelial-function-and-metabolic-parameters-a-randomized-controlled-trial-sapporo-athero-incretin-study-2-sais2
#19
RANDOMIZED CONTROLLED TRIAL
Hiroshi Nomoto, Hideaki Miyoshi, Tomoo Furumoto, Koji Oba, Hiroyuki Tsutsui, Arina Miyoshi, Takuma Kondo, Kenichi Tsuchida, Tatsuya Atsumi, Naoki Manda, Yoshio Kurihara, Shin Aoki
OBJECTIVES: GLP-1 improves hyperglycemia, and it has been reported to have favorable effects on atherosclerosis. However, it has not been fully elucidated whether GLP-1 is able to improve endothelial function in patients with type 2 diabetes. Therefore, we investigated the efficacy of the GLP-1 analogue, liraglutide on endothelial function and glycemic metabolism compared with insulin glargine therapy. MATERIALS AND METHODS: In this multicenter, prospective randomized parallel-group comparison study, 31 diabetic outpatients (aged 60...
2015: PloS One
https://www.readbyqxmd.com/read/26280343/metabolic-syndrome-polycystic-ovary-syndrome
#20
REVIEW
Rami Mortada, Tracy Williams
Polycystic ovary syndrome (PCOS) is a heterogeneous condition characterized by androgen excess, ovulatory dysfunction, and polycystic ovaries. It is the most common endocrinopathy among women of reproductive age, affecting between 6.5% and 8% of women, and is the most common cause of infertility. Insulin resistance is almost always present in women with PCOS, regardless of weight, and they often develop diabetes and metabolic syndrome. The Rotterdam criteria are widely used for diagnosis. These criteria require that patients have at least two of the following conditions: hyperandrogenism, ovulatory dysfunction, and polycystic ovaries...
August 2015: FP Essentials
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